#as GeneSilico Metaserver has limit (<990 amino acids), some of long proteins are divided into N and C terminus MHGGGPPSGDSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDPRQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKLLVDSNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGEEMDNKFGVEQPEGDEDLTKEKGHGGCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGMEPRYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQNGAAAHVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVDFSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQYPGAKYIIRDNGDRIDLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWSTFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQDTLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHINCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHISYLEMGHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKAHNNELEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKINISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHAMGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGESVEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELEREFERMREDREVLRVIFPTGDSKVVLPCNLLRMIWNA RPB1_1N sequence --------------EEEEEEEEEE---HHHHHH------------------------------------------------------------------HHHHHHHHHH--------------HHHHHHHHH----HHHHHHHHHHHH------------------------------------------EEEE--EEEEEE---------------HHHHHHHHH---HHHHHHH----------EEEEEEE----------EEE---------HHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH-----------------HHHHHHH--------------------------------------HHHHHH--------HHHHHHHHHHHHH---------EEE-----EEEE---------------EEEEE-----EEEE-------------EEEEE--------------------------------HHHHHHHHHHH-----EEE------EEEEEEEEEEEEEE---------HHHHHHHHH----------------------HHHHHHH--------------------------------EEEEE--EEEEEEE-----------EEEHHHHHH-HHHHHHHHHHHHHHHHHHHHH---EEEE------HHHHHHHHHHHHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHH---HHHHHHHHHHHHH--EEE------------------------------------------HHHH---------HHHHH---HHHHHHHHHHH---EEE------------EEEE-----------------------HHHHHHH-------HHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHH-------------HHHHHH-- RPB1_1N psipred --------------HHHHHHEEE----HHHHH--EEE---EEE---------------------------------------------------EEHHHHHHHHHHHHHHHHH---EE-----HHHHHHHHHH---HHHHHHHHHHHH----EE------------------------------------HHHH--EEEEEEE----------EE--HHHHHHHHHH--HHHHHH-----------EEEEEEE---------EEEE-------HHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHH----------HHHH-----HHHHHHHH-----EEEE-----EEEEEEEEEEE-------------HHHHH------------HHHHHHHHH---------EEEEE----EEEEEEE-----EEEE---EEEEEEE---EEEEE----HHHHHH----EEEE--EEEEEEEEE--------------------HHHHHHHHHHHH---EEE-------EEEEEHHHHHHHHHH--------HHHHHHHHHH------------EE----------EEEEEE----EEEE----------------------EEEEE--EEEEEEEEEEEEE-----EEEEEE----HHHHHHHHHHHHHHHHHHHHH---EEE-------HHHHHHHHHHHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHHHHH-HHHHHHHHH----EEEEEE-----EEEEEEEEEEEEEEEEE-EEE----------------------------------HHHHHHH-------HHHHHHHHH---HHHHHHHHHHHHHHHH---EEE-----EEEEEE-------HHHHH----------HHHHHHEEE-------------HHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHH------------HHHHHHH-- RPB1_1N prof -------------------EEEEEE--HHHHH--EEEEE--EEEEEE--------------------------------------EEEEE---EEEE--HHHHHHHHHHHHHH----E-----HHHHHHHH------HHHHHHHHHHH-----------------------------------------EEE----EEEEEE---------------HHHHHHHH----HHHHHH-----------HHHH-E-----------EE--------HHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHH-EEEEE----------------HHHHHHHHH------E-------------------------------HHHH------EE--HHHHHHHHHHHH---------EEEEE----EEEE--------------EEEEEE-----EEEEE-------------EEEE---------------------------------HHHHHHHHHH------E-------EEEEEE-HHHHHHHHH----E-HHHHHHHHHHH-----------------------EEEEEEE---EEEEE----------------------EEEEE---EEEEEEEEEEEEE----EEEEEEE----HHHHHHHHHHHHHHHHHHHH---EE--------HHHHHHHHHHHHHHHHHHHHHHHHHHH---------HHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----EEEEEEE------EEEEEEEEEE----E----------------EEE---------EEE---------EEEEEE-----------EEE-----HHHHHHHHHHHHHHH-----EE-----EEEEE--------EEEE----------HHHHHHHH-------------HHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHH------EEE----HHHHH-- RPB1_1N jnet --------------EEEEEEEEEE---HHHHHH--EEEEEE---------------------------------------------EEEE------HHHHHHHHHHHHHHHHHH--EE-----HHHHHHHH-----HHHHHHHHHHHHH---------------------------------------HHHHHH-HHHHHHHHHHHHHHH-------HHHHHHHHHHH-HHHHHHH----------EEEEEEEE--------EEEE--------HHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHH--------------------HHHHH---------------------EEE---------EEE--HHHHHH--------HHHHHHHHHHHHH--------EEEEE----EEEEE--------------EEEEEE----EEEE-------------EEEEE----EEEE------------------------HHHHHHHHHHH-----EE-------EEEEHHHHHHHEHEEH-------HHHHHHHHHHH--------------------HHHHHHHH-------------------------------EEEEE--EEEEEEE---------HHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHH----E--------HHHHHHHHHHHHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHHHHHHHHHHHHHHH------HHEEEE------HHHHHHHHHHHHHHH-----------------------------EEE---------HHHHHHH-----------E------HHHHHHHHHHHH-EEE---EEE-----EEEEE--------HHH-----------HHHHHHH-------------HHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHH-------EE---HHHHHHHH RPB1_1N sable -------------------EEEEEEE-HHHHHH---EEEE-------------------------------------------EEEEEEE--EEEEHHHHHHHHHHHHHH-------------HHHHHHHHHHH---HHHHHHHHHHHHH--EE------HHHHHHHHE-------E-EEE----EEEHHHHH---EHHHHHHHHHH----------HHHHHHHHHH--HHHHHH---------HHHHEEEEEEEE----EEEEEE----------HHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHH--------------------HE--------HHHHH--------EEEEEEEEE------EEEE-HHHHHHE--EEEEE---HHHHHHHHHH------EEEEEEE---EEEE---------------EEEEEEE---EEEEEEE--------EEEEEEEEEE---EEE---HHH--------EEEEEEE---HHHHHHHHHHH------------EEEEEEE-HHHHH-EEHH---EEE-HHHHHHHHHHH----------------EEEEHHHHEEEE-----EEEEE---------------------EEEEH----EE----HHH------HHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHH------------HHHHHHHHHHHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHH-----HHHHHHHHHH--EEE----EEE-----------------HHH--EEEEE------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--EEEE---EEEE---EEEEEE---------EEEEEE-------HHHHHHHH-------------HHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHH------EEEEE-HHHHHHHH- RPB1_1N proteus ----------------EEEEEEEEE--HHHHHHHHEEEEE-----------------------------E----------------HHHH---EHEHHHHHHHHHHHHHHHHH---EE-----HHHHHHHHHH---HHHHHHHHHHHH------------------------------------------EE----EEEEEEE----------EE--HHHHHHHHH---HHHHHHH-----------EEEEE----------EEEE--------HHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHH--------HHH------HHHHHHHH------EE------EEE--EEEEE--------------HHHHHH--------H--HHHHHHHHH---------EEEEE----EEEEEEE------E-----EEEEE-----EEEEE------H------EEEEE---EEEEEEE---------------------HHHHHHHHHHHH-----E-------EEEEEEHHHHHHHHH--------HHHHHHHHHH------------E----------HEEEEE-----EEEE----------------------EEEEE--EEEEEEEE----------EEEEEE----HHHHHHHHHHHHHHHHHHHHH---EEE-------HHHHHHHHHHHHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHHHHHHHHHHHHHHHH------EEEEEE-----EEEEEEEEEEE--------E-------------------------EE--HH----HHHHHHHH-------E--HHH-HHHHHHHHHHHHHHHH-EEEE---EE-----EEEEEE------HHHHH----------HHHHHHHEEEE----H-------HHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHH-------------HHHHHH-- RPB1_1N sspro4 --------------EEEEEEEEEEE--HHHHHHHHEEEEEEE-------------------------------------------EEEE--------HHHHHHHHHHHHHHHH--EEE-----HHHHHHHHH----HHHHHHHHHHHHHHHEE-------------------HHHHH----------HHHHHHH---HHHHHHHHHH----------HHHHHHHHHH--HHHHHHH--------HHHEEEEEEE------EEEEE---------HHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHH------------------HHHHHH----------------------E----------EE---HHHHHHH---EEE-HHHHHHHHHHHHH---------EEE-----EEE------HHHHH----EEEEEEEE---EEEE----HHHHH----EEEEEE---EEEEE---------------EEEE----HHHHHHHHHHH-----EE-------EEEEEHHHHHHHHHHH-------HHHHHHHHHHH-----------EEEEEEE----EEEEEEE------EE----------------------EEEEE--EEE-----HHH------HHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHH--EEEE--EE--HHHHHHHHHHHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHH-----HHHHHHHHHHHHH--------------------------------HHH-------HHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHH-EEEEE---EE----EEEEEEE---EE--EEE-----------HHHHHHHH-----------HHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHH--------E---HHHHHHHH- RPB1_1N psspred ---------------EE--EEEEE---HHHHHHHH--EE-E---------------------------------------------EE--------HHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHH----HHHHHHHHHHHHHH-----------------------HHHH------------------HHHHHHHHHHH--HHH------HHHHHHHHHH--HHHHHHH----------EEEEEEEE------EEEEEE--------HHHHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHH------HHHHH-------HHHHH--------------E------EEE--------------HHHHHH----EE--HHHHHHHHHHHHH---------EEEE---EEEEEE-------------EEEEEE----EEEEE--------HHH---EEEE----EEEEE-----------------------HHHHHHHHHHHH----EE------EEEEHHHHHHHHHHHHH-------HHHHHHHHHHH--------------------HHHHHHHH------EE-----------------------EEEEE--EEEEEEE-----------HHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHH-EE-----E---HHHHHHHHHHHHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHH-----HHHHHHHHHHH--------------------------------------------HHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHEEEE----EEE---EEEEEEE------HHH------------HHHHHHHH------HHHHHHH--HHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHH--------E--E-HHHHHHH- RPB1_1N spineX ---------------EEEEEEEE----HHHHHHH--EEEEE---EE-----E------------------EEE--------------EE---HHHHHHHHHHHHHHHHHHEEE------------EEEEEE-----HHHHHHHHHHH----EE------------------------------------EEEEE--EEEEEE----------EEEE-HHHHHHHHH---HHHHHH-----------EEEEEEEE--------EEEE----EEE----HHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH-------------------HHHH----------------------EEE------------------EEEEEEEEE----HHHHHHHHHH--------EEEEE----EEE------HHHH------EEEEEE----EEE----------------EEE-----EE----------------H--------HHHHHHHHHH----HEEE-------EEEEEE-EEEEEEEEE-------HHHHHHHHHH------------------EE---EEEEEE-------------------------------EEEEE--EEEEEEE---E-------HHHHHHHHH-HHHHHHHHHHHHHHHHHHHHH---EE--------HHHHHHHHHHHHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHHHHHHHH-HHHHHH-----HHHHHHH---------HHHHHH----EEE---E-----------------------------------HHHHHHHHH------E----------HHHHHHHHHHH--EEEE--EEE-----EEEEEE-------EE------------HHHHHHH----------------HHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHH-------EE-----EEEEE-- RPB1_1N raptorxss -------------EEEEEEEEEE----HHHHHHH-EEEEEE----E------E----------------E----------------EEE---H-----HHHHHHHHHHHHHHH----------HHHHHHHHH----HHHHHHHHHHHH-------------------------HH---------------HHHHHHHHHHH-HHHHH---HHH----HHHHHHHHHH--HHHHHHH----------HEEEEEEEE------EEEEE--------HHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHH--------HHH---------HHHHH---------------E-----EEE-------E-EEE--HHHHHH----EE--HHHHHHHHHHHH---------EEEE-----EEE-----HHHHHH-----EEEEE-----EEEE-------HHHHH--EEEE-----EEE----------------EEEE----HHHHHHHHHH-----EEEE-----EEEEEHHHHHHHHHHHH-------HHHHHHHHHH--H------------------HHHHHHHH------EEE----------------------EEEEE--EEEEEEEEHHEE------EEHHHHHHH-HHHHHHHHHHHHHHHHHHHHH----E----EEE-HHHHHHHHHHHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHH----HHHHHHHHHHHH-EEEEEEE--------EE---------------EEE--E------HHEHHHHHH-HH-HEEHEE------HHHHHHHHHH--EEE-----EE-----EEEEEE------HHHH-----------HHHHHHH-------HHHH-----HHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHH------E---E-HHHHHH-- RPB1_1N SPARROW ---------------EEE-EEE-----HHHHHHH--EEEEE----------E----------------------------------------------HHHHHHHHHHHH------------HHHHHHHHHH----HHHHHHHHHHHHH----------------------------------------EEEHHHHHHHHH----------------HHHHHHHHHH--HHHHHH---------HHHEEEEEEE-------EEEE-----E---HHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHH---------H--------HHHHHHH---------------------EEE------------H-HHHHHH--------HHHHHHHHHHHHH-------EEEEE-----EEE------HHHHH-----EEEE------EEEE--------------EEEE----EEEE------------------------HHHHHHHHHHH-----EE-------EEEEEEHHHHHHHHHH-------HHHHHHHHHH----------------------HHHHHHH------EEE----------------------EEEEE--EEEEEE---HH-------HHHHHHHHH-HHHHHHHHHHHHHHHHHHHHH----E-HHH----HHHHHHHHHHHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHHHHHHHHHH--------HHHHHH----HHH--HHHH-E-----HH---E--------------------H-------H-------HHHHHHHH---HHH--------HHHHHHHHHHHHHH-EEEE---EEE-----EEEEE-------HHHHH----------HHHHHHHH---------------HHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHH-----------E-HHHHHH-- RPB1_1N *SPARROW --------------HHHEEEEE-----HHHHHHEEEEEEE---HHHHH------------------H-H--HHHH----------EEEEEE---EE---HHHHHHHHHH-----H--E-----HHHHHHHHHHHH-HHHHHHHHHHHHHH-EE-------------------------------------HHHH--EEEEEEE-------H---EEEHHHHHHHHHH--HHHHHH-----------EEEEEEE----------EEEE-----HHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHEEEEE---------HHHH----HHHHHHHH------EE------EEEEEEEEEEEE-----HHH----HHHHHHHH----E----HHHHHHHHHH--------EEEEEE---EEEEEEHHH-HH-EE----EEEEEEE---EEEEE-----HHHHHH--EEEEEE--EEEEEEEEE------E----EEEE---HHHHHHHHHHHHH---EEE-----------HHHHHHHHHHHHHH-HHHHHHHHHHHHHEE------------------EE--EEEEEE-----EEEEE---------------------EEEEE---EE---------------EEEEEEE---HHHHHHHHHHHHHHHHHHHE-----EE-------HHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------HHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHE------EEEHHHHHHHH---EE------------------E---------EEE--E-----HHHHHHHHH-----EEEEEEE------EEHHHHHHHHHHHEEE---EE-----EEEEEE------EEEEE-----EEE--HHHHHHEEEEEE-------HHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHH----------HHHHHHHH RPB1_1N HMMSTR --------------E----EEEE----HHHHHHH---------------------------------------------------EEEEE---EE-HHHHHHHHHHH--E------E------HHHHHHHH-----HHHHHHHHHHHH----E-------------------------E-------E----EEE--EEEEEE-----------EEE-HHHHHHHHHH--HHHHHH---------HHH-EEEEEEE--HHH---------------HHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHH--------------------HHHHH--------HH----E---EEEEEEEE-------EEEEEHHHHH--EEEEE-----HHHHHHHHHH-------EEEEE-----E------------------EEEEE-----EEEEE------HHHEEEEEEEEE----EEE-HHHHHHH-------EEEEE----HHHHHHHHHH-EHHHH-EE----EE------HHHHHHHHHH----EEEHHHHHHHHHH------------E-----EEEHHHHHH--------EEE-----------------------EEEE---EEE----HHHH------HHHHHHHH--HHHHHHHHHHHHHHHHHHHHH------HHHH----HHHHHHHHHHHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHH-----HHHHHHHH-------E--E-----E--E-----------------E---------HHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHH---EE-----EE-----EEE--HHH--E-HHHEEEEE---H---HHHHHHHH-----------HH--------------HHHHHHHHHHHHHHHHHHHHHH------EEEEE--HHHHHH-- RPB1_1N porter -------------------EEEEE---HHHHHHH-EEEEE-----E-----------------------EEE--------------EEEE------HHHHHHHHHHHHHHHHH--EEEE-----HHHHHHHH----HHHHHHHHHHHH----E-------------------HHHHHHH---------HHHHH---HHHHHHHHHHHHHHHHH----HHHHHHHHHH--HHHHHHH----------EEEEEEE---------EEEE--------HHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHH-------HHHH-------HHHHHHHH-----HHHHH----------EEE------E-------HHHHHH--------HHHHHHHHHHHH---------EEEEE----EEEE------HHHH-----EEEEE-----EEEE----HHHHH----EEEEEE---EEEE--E------------EEEEE--H-HHHHHHHHHHHH----EE-------EEEEHHHHHHHHHHH--------HHHHHHHHHHHH--------------EEEEE--EEEEEE-------E---------------EE------EEEEE--EEEEE---------HHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHH--EEEEE--EE--HHHHHHHHHHHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHHHHHHHHHHH-------HHHEEE------HHHHHHHHHHHHHHH----E------------------------HHHH-HH----HHHHHHHHH----HHHHHHHH-----HHHHHHHHHH--EEEEE--EEE----EEEEEEE-------EE------------HHHHHHHHH-----HHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHH-------EE--E-HHHHHH-- RPB1_1N spine -----------------------------HHHHH-------------------------------------------------------------EE-EEE-------EEEEE------------HHHHHHH----------EE---------------------------------------------------HHHHHHHHH--------EEEE-HHHHHHHHHHH-----EEE-----------EEEEE-----------EEE-------HHHHHHHHHHHHHHHHHHH------HHHHHHH-HHHHHHHHHHHH--------HHHHH----HHHHHHHHH--------------------EEE-------------------------------HHHHHHHHHH---------EEEE----EEEEE--------------EEEE------EEEE---------------EEE--------------------------------HHHHHHHHHHH-----EE-------EEEEE--HHHHHHHH----EE-------HHHHHH-----------------------EEEEE------EE-----------------------EEEEE---EEEEEE-----------EEEEE-------HHHHHH--HHHHH---EEE--------------HHHHHHHHHHHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHHHHHH-----HHHHHHH-----EEEE-----------EEEEEE-----------------------------------------------EE---------HHHHHHHHH----HHHHHHHHHHHHHHH--------HHHHHHHH-----------------------HHHHHHH------HHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHH---EEEEE-------EEE---HHHHHHHH RPB1_1N nnssp ---------------------------HHHHHHH------------------------------------------------------EEEEEEE-HHHHHHHHHHH----------------HHHHHHHHHH----HHHHHHHHHHH----------------------------------------------HHHHHHHHHH--HHHHHHHHH--HHHHHHHHHH--HHHHHH---------HHHHEEEE----------EEEE------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----------------------HHHHHHHHHHHHHHHH-------EEEEEEEE-------EEEEEHHHHHHHHHHHH-----HHHHHHHHHH-------EEEEE------------------------EEEEE-----EEEEE---------EEEEEEEEE----EEE-HHHHHHH-------EEEEEE---HHHHHHHHHHHHHHHH--------------HHHHHHHHHHH---EEEEHHHHHHHHHH------------------EEEHHHHHHHH----EEEEEEE-------------------EEEEEE--EEEEEEEEE---------EEEEEEEEE---EEEEEE--HHHHHHHHHHH----------------HHHHHHHHHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHHHHHHHH--HHHHHHHHH---EEEEEE-----EEEEEEEEEEE--------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------EEE-----EEEEEE---------HHHHHHHHH-HHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---EEEEEEE----EEEE-HHHHHHHH-- RPB1_1N pssfinder ---------------HHHHHEEEE---HHHHHHHH---------------------------HHHHHHHHHHH-------------EEE-------HHHHH-HHHHHEEEEE-----------HHHHHHHHH---------HHHHHH-----HHH-----------------HHHHHHH---------HHHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHH---EEEE----------EEEEEEE----------EEE------HHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHH----HHH------------------HHHHHHHHH-------------EE----EEEE--------------------HHHHHH-----HHHHHHHHHH--------EEEE-----EEEEEE------------EEEE-------EEEEE-------------EEEEEE----EEEEEE--------------------HHHHHHHHHH----EEEE-------EEEEHHHHHHHHHHHHHH--EEE---EEEEEEEE-EE-------------------EEEEEEE---EEEEE----------------------EEEEE--EEEEEE-----------EEEEEEE------HHHHHHHHHHHHH---EEE---EE-----------HHHHHHHHHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHHH--------HHHHHHHH----EEEEE-----------EEEEE----------EEEEE-----------------EEEE----------EEEE--------HHHHHHH-HHH-HHHHHHHHHHHHHHHH--HHHHH-HHHHH-------------------------HHHHHH--------HHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHH----EEEEEE-----EE----HHHHHHHH RPB1_1N sspal -------------------EEEEEEEE-HHHHHEEEE--------------------------------------------------HHHHH-EEEEEEEE----EEEEEEEE---EEEE----HHHHHHHHH----HHHHHHHHHHHH------------------------------------------HHHHHHHHHHHHH---HHHHHHEEEE-HHHHHHHHHH----EEEE----------EEEEEEE----EEEE--EEEE-HHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHEEE---------------------HHHHHHHHH--------------------EEEE--------------------------HHHHHHHHHHHHHH---------EEEE----EEEEEEE-----------EEEEEEE----EEEE--------------------EEEEEEEEEEE--------------HHHHHHHHHHHHHHH-----EEEE------HHHHHHHHHHHHHHH------HHHHHHHHHHHHH---------------------EEEEEEEE-------------------------------EEEE---EEEEEEE----------EEEE--------EEEEEEE-EEEEE--EEEE---EEEE------HHHHHHHHHHHHHHHHHHHHHHHHH------------HHHHHHHHHHHHHH--------HHHHHHHHH--EEEEEEE--------EEEEEEEE----------------------------------------------------------HHHHHHHHHH----HHHHHHHHHEEEEEHHHHHHHHHHHHHHHH---------HHHHHHHHHHH--HHHHHHHHHEEEE-HHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHH---EEEEEEE----EEEE----------- RPB1_1N ssp -------------------EEEEE----HHHHHH----------------------------------------------------EE-----------HHHHHHHHHHHHH----EEE-----HHHHHHHH-HHHHHHHHHHHHHHHHHHE-------HHH-HHHHHH------------------HHHHHHH----HHHHHHHHH-H-HH-----HHHHHHHHHH----HH----------------E--------------------------HHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHH------------------HHHH-----------------------------------------HHHH-----------HHHHHHHHHHH--------------------E----------------------------EEE------------------------------------------EEE------HHHHHHHHHH--------------EE---HHHHHH-----------HHHHHHHHHHH--------------------HHHHH--------------------------------------------------HHHH--HHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHH---EEE--------HHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHH------HHHHHHHHHHH--------------------------------------------HHHHHHHHH-------------------HHHHHHHHHHHEEE----------------------------------------HHHH------------------HHHHH------HHHHHHHHHHHHH----HE----------------HH-HH--- RPB1_1N sspred ---------------EEEEEEEE----HHHHHHHHHEEEEE-------------------------------------------------------HHHHHHHHHHHHHHHHHH---------HHHHHHHHH-----HHHHHHHHHHHH----------------------------------------EEEE---HEEEE------------EE--HHHHHHHHHH--HHHHHH------------EEEEEEE--------EEE---------HHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHH-------------------HHHHHH-----EE--------------EEE--------------HHHHH---------HHHHHHHHHHHHH--------EEEEE---EEEEEE----HHHHH-----EEEEE-----EEEE-------------EEEEE-----EEE------------------------HHHHHHHHHHHH----EEE-------EEEHHHHHHHHHHHH-------HHHHHHHHHHH--------------------HHHHHHHH-------E-----------------------EEEEE--EEEEEEE-----------HHHHHHHH--HHHHHHHHHHHHHHHHHHHHH---EEE-------HHHHHHHHHHHHHHHHHHHHHHHHHHH---------HHHHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHH-----HHHHHHHHHHH---E------------------------------E---------HHHHHHHHH-----HHHHHH-----HHHHHHHHHHH---EEE---EEE-----EEEEEE---------------------HHHHHHHH--------------HHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHH-------------HHHHHH-- RPB1_1N netsurfp ---------------EEEEEEEE----HHHH-HH--EEEEEE-------------------------------------------EEEEE-------HHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHH-----HHHHHHHHHHHHHH---------------------------------------H------H--EH------------E--HHHHHHHHHHH-HHHHHHH-----------EEEEEEE------EEEEEE---------HHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHH-------HH--------HH-EH----------------------EEE----------E-----EE-----------HHHHHHHHHHH---------EEEEE---EEEEEE--------------EEEEEEE---EEEE--------HHHH--EEEE----EEEE-----------H-HHHHHHH--H-HHHHHHHHHHHH----EEE------EEEEEEEEEEEEEEEE-------HHHHHHHHHHH--------------------HHHHHHHHH-----EEE----------------------EEEEE--EEEEEEE----E------EEEEEE-----HHHHHHHHHHHHHHHHHHHHH------------HHHHHHHHHHHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHHHHHHHHHHHH------HEEEEE-------E-EEEEEEEH--EH------------------------------EE-----------EHHHHHH-----------HHHHHHHHHHHHHHHH--EEEE--EEE-----EEEEEE------HHHH-----------HHHHHHHH---------------HHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHH------------HHEHHH-- RPB1_1N soprano ----------------EE-EEEEE---HHHHHHH--EEEE----------------------------------------------EEE-------HHHHHHHHHHHHHHHHH----------HHHHHHHHH----HHHHHHHHHHHH------------------------------------------HHH---HHHHHHHH-------------HHHHHHHHHH--HHHHHH-----------EEEEEEE---------EEEE--------HHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHH------------------HHHHHHH---------------------EEE--------------HHHHHH--------HHHHHHHHHHHHH--------EEEEE----EEEE---------------EEEEE-----EEEE--------------EEEE-----EEE------------------------HHHHHHHHHHH-----EE-------EEEEEHHHHHHHHHHH-------HHHHHHHHHHH---------------------HHHEEEE------EEE----------------------EEEEE--EEEEEEE-----------EEHHHHHH--HHHHHHHHHHHHHHHHHHHHH---EE--------HHHHHHHHHHHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHE------HHHHHHHHHHH----------------------------------E---------HHHHHHHHH-----HHHHHHH-----HHHHHHHHHHH-EEEE----EE-----EEEEEE-------HHH-----------HHHHHHHH------------HHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHH--------E----HHHHHH-- RPB1_1N consensus MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQRRILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVAPRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPEDLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNILGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSKLFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQSFPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVDMKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALNDSSLDLSMDSDNSMSVPSPTSATKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSVPQVNSSESSGGTSSESIPQTATQPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAATKIPTPIVGVKRTSSPHKEESPKKTKTEEDETSEDANCLALSGHDKTEAKEQLDTETSTTQSETIQTAASLLASQKTSSTDLSDIPALPANPIPVIKNSIKLRLNR PAPOLA_1 sequence --------------------------------HHHHHHHHHHHHHH--------HHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHH-----EEEEE-------------EEEEEE------HHHHHHHHHHHHH-------EEE-------EEEEEE--EEEEEEEEE--------------HHHH----HHHHHH--HHHHHHHHHHH---HHHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHHH-----HHHHHHHHHHHHH-------EEE--------------------------EEE--------------HHHHHHHHHHHHHHHHHHHHHH-----HHHH-----HHHH---EEEEEEE---HHHHHHHHHHHHHHHHHHHHHHH-----EEEE-----------------EEEEEEEEEEE-------------HHHHHHHHHHHHHHHH--------EEEEEEEEE---------HHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEE---- PAPOLA_1 psipred --------------------------------HHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHH---EEEEEE-EEE----------EEEE-------HHHHHHHHHHHHH----------------EEEEEE---EEHHHHHHHHHH----------HHHHH---HHHHHH----HHHHHHHHH---HHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHH-------EEEE--------EEEE--------------EE--------------HHHHHHHHHHHHHHHHHHHHHHH----HHHHH---HHHHHHHHEEEEEEE----HHHHHHH-HHHHHHHHHHHHHH----EEEE------------------EEEEEEEEEEEE--------EEE----HHHHHHHHHHHHHHHH------EEEEEEE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEEEE-- PAPOLA_1 prof ------------------EEEE----------HHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHH-----EEE---EEEEE------EEEEEE--------HHHHHHHHHHH---------------EEEEEEE-----HHHHH---------------HHHHH-------EEE----HHHHHHHH---------HHHHHHHHHHH------EEE-----HHHHHHHHHHHHH-------HHHHHHHHHH--------EE--------------------------------------------HHHHHHHHHHHHHHHHHHHHHHH-------------------EEEEEEE-----HHHHHHHHHHHHHHHHHH--------EEEEEE----------------EEEEEEEEEE-----------EE---HHHHHHHHHHH------------EEEEEE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ PAPOLA_1 jnet ---------------------------------HHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHH------HH-----EEEEE---EEEE------EEEEEE------HHHHHHHHHHHHH------EEEE-------EEEEEE--EEEEEEEEEE-------------HHHHHH--HHHHHH----HHHHHHHHH----HHHHHHHHHHHHHHHH------------HHHHHHHHHHHHHH------HHHHHHHHHHHHH------EEE-------------------------EEEE---------HHHH-HHHHHHHHHHHHHHHHHHHHHH-----HHHHH----HHHH--EEEEEEEE---HHHHHHHHHHHHHHHHHHHHHHHH----EEEE-----------------EEEEEEEEEEE-------------HHHHHHHHHHHHHH----------EEEEEEEEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEEEE-- PAPOLA_1 sable -----------------------------------HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHH----EEEEE-HHHH--EEE--EEEEEEEEE----HHHHH-HHHHHHHH------EEEE-----EEEEEE---EEEEEEEEEEE--EEE-------HHHH------HHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHH-EEE----EEEHHHHHHHHHHHHHH-----HHHHHHHHHHHHH------EEE------------EEE----HHHHH--EEEEE---EEEEE-----HHHHHHHHHHHHHHHHHHHHHHH----HHHH----------EEEEEEEEEE--HHHHHHHHHHHHHHHHHHHHHHHH---EEEEEEE--EEEE--------EEEEEEEEEEEEE--------EE--HHHHHHHHHHHHHHHHHH--EEE-EEEEEEEE--HHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEEEE-- PAPOLA_1 proteus -----------------H--------------HHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHH---EEEEE--EE-----------EEEE------HHHHHHHHHHHHHH-H-HHH----HH----EEEEE----EEHHHHHH---------------HHHH---HHHHH------HHHHHHHH---HHHHHHHHHHHHHHHHH-------------HHHHHHHHHHHHH----HHHHHHHHHHHHHH-------EE----------------------------EE--------------HHHHHHHHHHHHHHHHHHHHHHH----HHHHH----HHHH--EEEEEEEE---HHHHHHHHHHHHHHHHHHHHHHHH---EEE--------------------EEEEEEEEEEE--------EE-----HHH-HHHHHHHHHHHHH-----EEEEEEEEH--------HHH------------EE-----------------------------------------------EEE---------------E-----------------------------EEEEEE-----------------------------EEEEE----------------HHHH----------------HHHHH-----------------HHHHH--------------------EEE-EEEEEE-- PAPOLA_1 sspro4 ------------------EE------------HHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHH---EEEEEE-------------EEEEEEE-----HHHHHHHHHHHHHH-----EEEEE-----EEEEEEEE-EEEEEEEEE--------------HHHHH---HHHHHHH--HHHHHHHHHH---HHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHHH-----HHHHHHHHHHHHHH------EEE-------------------------EEEE--------HHH---HHHHHHHHHHHHHHHHHHHHHHH----HHHHH---HHHHHH-EEEEEEEEE--HHHHHHHHHHHHHHHHHHHHHHHH----EEEE-----------------EEEEEEEEEEEE--------EE--HHHHHHHHHHHHHHHH--------EEEEEEEE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEEEE-- PAPOLA_1 psspred ---------------------EE---------HHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHH---EEEEE--------------EEEEEE-----HHHHHHHHHHHHHH--------E----E-EEEEEEE--EEEEEEEEEE--------------HHHH---HHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHH-HHHHHH----HHHHHHHHHHHHHHH----HHHHHHHHHHHHHH------EEE-------------------------EEEE----------H---HHHHHHHHHHHHHHHHHHHHHHH----HHHHH----HHHHH--EEEEEEEE--HHHHHHHHHHHHHHHHHHHHHHHH---EEEEE-----------------EEEEEEE-EEEEE------EEEE-HHHHHHHHHHHHHHHHH------EEEEEEEEEEE----------HHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEE--- PAPOLA_1 spineX -----------------------------------HHHHHHHHHHH--------HHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHH----EEEE---------------EEEEE------HHHHHHHHHHHHH------EEEE----EEEEEEEEE--EEEEEEEEEE---------------------HHHHHHH---H-HHHHHH----HHHHHHHHHHHHHHHHH---HHHHH-----HHHHHHHHHHHHH-------EEEEEEEEEEE--------EE-----------EE----------EEEEEE--------------HHHHHHHHHHHHH--E----------EE--E------HH---EEEEEEEE---HHHHHHHHHHHH--EEEE--------EEEEEE----------------EEEEEEEEEEEEE-----------------EE--EEE----EEEEEEEEEEEEEEEEEE-----E--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PAPOLA_1 raptorxss --------------------------------HHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHH-----EEEEEE-------------EEEEEEE-----HHHHHHHHHHHHH-------EEEE------EEEEEE--EEEEEEEEE--------------HHHH----HHHHH------HHHHHHHH---HHHHHHHHHHHHHHHHHHH-HH-------HHHHHHHHHHHHHH-----HHHHHHHHHHHHHH-------EE--------------------------EEE---------HHH--HHHHHHHHHHHHHHHHHHHHHHH----HHHHHH---HHHH--EEEEEEEE---HHHHHHHHHHHHHHHHHHHHHHHH-----EEEE---------------EEEEEEEEEEEEEE-------EE----HHHHHHHHHHHHHHHH-------EEE--E-------------H----HHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEEEE-- PAPOLA_1 SPARROW --------------------------------HHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHH-----EEEEE------E------EEEEEE------HHHHHHHHHHHHH------EEEE-----E-EEEEEE--EEEEEEEEE--------------HHHH----HHHHHH---HHHHHHHHHH---HHHHHHHHHHHHHHHHH-------------HHHHHHHHHHHHH-----HHHHHHHHHHHHHH-------EE-----------E--------------EEE--------------HHHHHHHHHHHHHHHHHHHHHH-----HHHH------HHH---EEEEEEE---HHHHHHHH-HHHHHHHHHHHHHH------EE------------------EEEEEEEEEE-----------E--HHHHHHHHHHHHHHH---------EEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PAPOLA_1 *SPARROW ----------------HHHH------------HHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHH--EEEEE-EEEEEE--------EEEEE-EEEEHHHHHHHHHHHHHH-HHHHHHHH---H----EEEEE----EEEEEHHHE-----------HHHHHHH--HHHHHHE------HHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHH-----HHHHHHHHHHEEHH------EEEE--H------EEE-------H----------------------HHHHHHHHHHHHHHHHHHHHHHHHHH-HHHHHHH--HHHHHHHEEEEEEE---HHHHHHHHHHHHHHHHHHHHHHHH--EEEEE-------------------EEEEEEE-EE---------EEEEEE-HHHHHHHHHHHHHHHHH-----EEEEEEEE-------E-------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHH------------------HHH-----------------------------------------HHHHHHHEEEHHH PAPOLA_1 HMMSTR --------------------------------HHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHH--E-EEEEEHHHHH--------EEEEEEE-----HHHH--HHHHHHH----EEEEEEE------EEEEEE--EEEEEEEEE-----E--------HHHH----HHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHH---E------E-HHHHHHHHHHHHHH-----HHHHHHHHHHHHH-------E--------------------HHHHH----EE-------E------HHHHHHHHHHHHHHHHHHHHHH-----HHHH-----HHHH--EEEEEEEEE--HHHHHHHHHHHH--HHHHHHHHH----EEEEEE----EE----------EEEEEEEEEEE-------------HHHHHHHHHHHHHHHHH--------EEEEEEEEHHHHHHH-----------------EEE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-----EEE--- PAPOLA_1 porter -------------------------------------HHHHHHHHH--------HHHHHHHHHHHHHHHHHHHHHHHHHH----------------EEEE---EEEE--------EEE-----------------HHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHH-----------HHHHH---EEEE--------HHHHHH------HHHHHHHHHHHHHH---------------HHHHHHHHH------HHHHHHHHEEEEE--------------------------------------------------EEEEE----HHHHHHHH-----HHHHH-HHHHHHHHH----------EEEEEE-----HHHHHHHHHH---EEEEEE------EEEEE--------------------EEEEEEEEE---------EEEEEE-------HHHHHHH--HHHHHHHHHHHHHH-HHHHHHH-----------------EEEE---------------------------------------------------------EEE------------------------------------EEE-----------------------------EEEE---------------------------EEEE------HHHHHH-------HHHHHHHHHHHHH---------------------------EEEE-- PAPOLA_1 nnssp --------------------------------HHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHH-----EEEE-HHHHH--------EEEEEEE-----HHHH--HHHHHHH----EEEEEEE------EEEEEE--EEEEEEEEE--------------HHH-----HHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHH------------HHHHHHHHHHHHHH------HHHHHHHHHHHHH------EEEE--------------------------EE--------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHH--EEEEEE-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------------HHHHHHHHHHHHHHHHH-----EEEEEEEE-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------EEEEE----EEEEEE-----------------------------------------------------------------------------------EEEEEE-----------------------------EEEEEE--------------------HHHHHHHHH----HHHHHHHH--------HHHHHHHHHHHHH-------------------------------- PAPOLA_1 pssfinder --------------------EEE---EEE------HHHHHHHHHHH--------HHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHH-----EEEE---------------EEEE----------------HHHHHHHHHHHHHHHHHHH-HHH------HHHHHHHHHHH-----------HHHHHHH---HHHHH------HHHHHH------HHHHHHHHHHHHH---------EEE----HHHHHHHHHHH-----HHHHHH--EEEE--------EEE-----------------------------------------EEE--EEEHHHHHHHHHHH-HHHH--HHHHHHHH----------EEEEEEEE----HHHHHHHHEE----EEEE-------EEEEEE-------------------EEEEEEEEEE-------EEEEE--------HHHHHHHHHHHHHHHHHHHHHHH--HHHHHHH-HHHHHHH---------EEEEE-------------------------------------------------------EEEE----------------------------------EEEEE-----------------------------EEEE---------------------------EEEE----HHHHHHHHHHH-----HHHHHHHHHHHHH--------------------------EEEE-- PAPOLA_1 sspal -----------------------------------EEEEHHHHHHHH-EEEHHHHHHHHH---HHHHHHHHHHHHHHHH-----------------EEEE--EEEEEEE---------------HHHHHHHHHHHHHH--HHHHHHHHHHHHH--EEEEEEE---HHHHHHHHH---HHHHHHHHHHHHHH---EEEEEEE----HHHHHHHHH-----HHHHHHHHHHHHHHH------------HHHHHHHHHEEEEE------EEEEEEEEEE--------HHHHH------------------------------------EEEEEEE--HHHHHHHHH-EEEE------HHHHHHHHHH--HHHHHEEEEEEE--HHHHHHHHHHH-EEEEEEEEEE-------EEEE---------------------EEEEEEEEE--------EEEEEEE-------HHHHHHHHH-EEEHHHHHHHHHHHHHHHHH----HHHHHHHHH----EEEEEEE------------------------------------------------------EEEEE--------------------------------EEEEEEE--EEEE----------------------EEEEEEEE-------------------HHHHHHHHH---HHHHHHHHH--------HHHHHHHHHHH---------------------EEEEEEEEEE-- PAPOLA_1 ssp ----------------------------------HHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHH--EEEEEE--------------EEEEE-----HHHHHHHHHHHHH-----------------EEEEEEE-EEEEEEEEEEEH------------HHHHHH-HHHHHH----HHHHHHHHH---HHHHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHH-----HHHHHHHHHHHH--------EEEE------------------------------------------HHHHHHHHHHHHHHHHHHHHHHH----HHHHH-----HHH-HEEEEEEE----HHHHHH------HHHHHHHHHHHH---EH--------------------EEEEEEEEEEE----------------HHHHHHHHHHHHH---------EEE--EE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EE--- PAPOLA_1 sspred --------------------------------HHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHH---EEEEEE------------EEEEEE------HHHHHHHHHHHHHH-------EE-----EEEEEEEE--EEEEEEEEEE-------------HHHH----HHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHHH----HHHHHHHHHHHHHHH-----EEE-------------------------EEEE--------HHHHH-HHHHHHHHHHHHHHHHHHHHHH-----HHHHH--HHHHHHH--EEEEEEE---HHHHHHHH-HHHHHHHHHHHHHHH----EEEE------------------EEEEEE--E-----------E-----HHHHHHHHHHHH----------EEEEEEEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PAPOLA_1 soprano --------------------------------HHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHH----EEEEE-------------EEEEEE------HHHHHHHHHHHHH-------EEE-------EEEEEE--EEEEEEEEE--------------HHHHH---HHHHHH----HHHHHHHHH---HHHHHHHHHHHHHHHHH------------HHHHHHHHHHHHHH-----HHHHHHHHHHHHH-------EEE---------------------------EE--------------HHHHHHHHHHHHHHHHHHHHHHH----HHHHH----HHHH--EEEEEEEE---HHHHHHHHHHHHHHHHHHHHHHHH---EEEEE-----------------EEEEEEEEEEE---------EE-----HHHHHHHHHHHHHH--------EEEEEEE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEE--- PAPOLA_1 consensus MADGVDHIDIYADVGEEFNQEAEYGGHDQIDLYDDVISPSANNGDAPEDRDYMDTLPPTVGDDVGKGAAPNVVYTYTGKRIALYIGNLTWWTTDEDLTEAVHSLGVNDILEIKFFENRANGQSKGFALVGVGSEASSKKLMDLLPKRELHGQNPVVTPCNKQFLSQFEMQSRKTTQSGQMSGEGKAGPPGGSSRAAFPQGGRGRGRFPGAVPGGDRFPGPAGPGGPPPPFPAGQTPPRPPLGPPGPPGPPGPPPPGQVLPPPLAGPPNRGDRPPPPVLFPGQPFGQPPLGPLPPGPPPPVPGYGPPPGPPPPQQGPPPPPGPFPPRPPGPLGPPLTLAPPPHLPGPPPGAPPPAPHVNPAFFPPPTNSGMPTSDSRGPPPTDPYGRPPPYDRGDYGPPGREMDTARTPLSEAEFEEIMNRNRAISSSAISRAVSDASAGDYGSAIETLVTAISLIKQSKVSADDRCKVLISSLQDCLHGIESKSYGSGSRRERSRERDHSRSREKSRRHKSRSRDRHDDYYRERSRERERHRDRDRDRDRERDREREYRHR CPSF6_1 sequence -------------------------------------------------------------------------------EEEEEEE-------HHHHHHHHHH------EEEEEEE---------EEEEE---HHHHHHHHHH--------------------HHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHH---------HHHH----------HHHHHHHHHHHHHH-------HHHHHHHHHHHHHH------------------------HHHHHH------------HHHHHHHHHH-----------HHHHHHHHHH-- CPSF6_1 psipred -------------------------------------------------------------------------------EEEEEEE--------HHHHHHHHH-----EEEEEEEEE--------EEEEEE--HHHHHHHHHH-----------EEE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHH------------EEEE-------------------------------------------------------------------------------- CPSF6_1 prof --------------------------------------------------------------------------------EEEEE--------HHHHHHHHHHH-----EEEEEE---------EEEEEEE--HHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EE----------------------------------------------------------------------- CPSF6_1 jnet ---------------HHH--------------HHH--------------------------------------------EEEEEEE-------HHHHHHHHHH------EEEEEEE---------EEEEE----HHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHH-----------HHHH----------HHHHHHHHHHHHH-----------HHHHHHHHHHH------------------------------------------HHHHHHHHHHH--------------------- CPSF6_1 sable ---------E---------------------------------------------------------------------EEEEEE--------HHHHHHHHHH-------EEEEEE---------EEEEEE---HHHH----------------E------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHH---HHHHHHHHH-HHHH-------------------HHHHHHHHHHHHH-----------HHHHHHHHHHHHHH------------------ CPSF6_1 proteus -------EEEEE---HHHHHHHH---------HH-------------------------------------EEEEE---EEEEEEE-------HHHHHHHHHH----HHHHHHHHHH---------EEEEE--HHHHHHHHHH--------------------HHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHH-----HHHHHHH---------HHHHHHHHHHHHHHHH-H---HHHHHHHHHHHHHHH--HHH------------------------------------HHHHHHHHHHHHHH------HHHHHHHHHH--- CPSF6_1 sspro4 --------------------------------------------------------------------------------EEEEE--------HHHHHHHHHHH----EEEEEEEE---------EEEEE---HHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHH-----------HHH--------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--- CPSF6_1 psspred ---------------HHHHHHH--------------------------------------------------------EEEEEEE--------HHHHHHHHHHH------EEEEEEE--------EEEEEE--HHHHHHHHHH--------------------HHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHH------HHHHHHHHH-HH---HHHHHHHHHHHHHHHHH------HHHHHHHHHHHHH----------------HHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH- CPSF6_1 spineX ---------EE---------------------------------------------------------------------EEEEE--------HHHHHHHHHH------EEEEEEEE----------EE-------HHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HH-----------HHHH-------------HHHHHHHHH---------HHHHHHHHHHHHHH-------------HHHHHHH----HHHHHHH-----------HHHHHH--HH----------------------- CPSF6_1 raptorxss ---------------HHH-------------------------------------------------------------EEEEEEEEE-----HHHHHHHHHH------EEEEEEE------EEEEEEEEE--HHHHHHHHH-------------EE-----------HHH----H----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HH-----------------------------------------------HHHHHHH----HHHHHHHH------------HHHH-HHHH-HHH--------------HHHHHHH---------------HHHHH--- CPSF6_1 SPARROW -------E-------HHHH------------------------------------------------------------EEEEEE--------HHHHHHHHHHH----EEEEEEEE------E--EEEEE---HHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH---------------------------------------------- CPSF6_1 *SPARROW ------EEEEEE-HHHHHHH------HHHHHHHHHHHH-----------------------------------------EEEEEEEEEEEEE-HHHHHHHHHHH-----EEEEEEE------EE--EEEEEEEHHHHHHHHHHH----E----EEEEE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHH--HHHHHHHHHHH-H--HHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHH------------HHH-H-------HHHHHHHH--------HH-HHHHH-HHHHHHH---HHHHHHHHHHHHHH CPSF6_1 HMMSTR -------EEEE----HHHHHHH----------HHH--------------------------------------------EEEEEEE-------HHHHHHHHH------EEEEEEEE--------EEEEEEE--HHHHHHHHHH-----------EE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHH--------------------------HHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHH-----------------------------HHHHHHHHHHH----HHHHHHH---HHHHHHHHHHHH-- CPSF6_1 porter ----HHHHHHHH--HHHHHHHHHH-------HHHH----------------------------------------E---EEEEE---------HH-HHHHH--------EEEEE-------------EEEE-----HHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHH----E-HHHHHHHH--------HHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHH---------------HHHH---HHHHHHHHHH-------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--- CPSF6_1 spine -------HHHHHH----------------------------------------------------------EEEE----EEEEEE---------HHHHHHHHH-------EEEEE----------EEEEE------HHHHHHH-------------------HHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHH-------HHHHHHH---------HHHHHHHHHHHH-----------EEEE------------------------------------------------HHHHHH-HHHHHH------HHHHHHHHHHHHH- CPSF6_1 nnssp ------EEEEEEE--HHHHHHHHH----EEEEE--------------------------------------EEEEEE--EEEEEEE-------HHHHHHHHHHH-HHHHHHHHHHHHHH------EEEEEE--HHHHHHHHHH-----------------HHHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHH-----HHHHHHHHHHHH-------HHHHHHHHHHHHH----HHHHHHHHHHHHHHH-------------HHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-- CPSF6_1 pssfinder ------EE-EEEE-----HHHHH----EEE----------------------------EE-----------EEEEE----EEEEE--------HHHHHHHHHHH------EEEEE---------EEEEEE-------HHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHH-----HHHHHHHHH--------HHHHHHHHHHHHHH--------EEEEEE--HHHHH-------------------------------------------------------------------------- CPSF6_1 sspal -------HHHHHHHHHHHHHHHHH-----------------------HHHHHHHHH---------------EEEEEEE-EEEEEEE------HHHHHHHHHHH------HHHHHHHHHH------EEEEEEEHHHHHHHHHHHH----------EEEE-HHHHHHHHHH---------------------------------------------------------------------------------------EEEE--------------------------------------------------------------------------EEEE-------------------------------------------------------------------------HHHHHHHHH-------HHHHHHHHHHH-----HHHHHHHHH---------HHHHHHHHHHHHHH---------------------------------------------------------------------------- CPSF6_1 ssp -----------------------------------------------------------------------------------------------HHHHHH-----------------------------------HH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- CPSF6_1 sspred -------------------------------------------------------------------------------EEEEEEE-------HHHHHHHHHHH-------EEEEE---------EEEEE---HHHHHHHHHH------------EE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH------------------------H-------------------------------------------------------------------HHHHH--- CPSF6_1 netsurfp -------------------------------EEHH-H------------------------------------------EEEEEEE-------HHHHHHHHHHH----EEEEEEEE---------EEEEEE--HHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHH-------HHHHHHHH-------HHHHHHHHHHHHHHHHHH-------HHHHHHHHH-------------------------------------------------H---------------------HH---- CPSF6_1 soprano -------------------------------------------------------------------------------EEEEEEE-------HHHHHHHHHH------EEEEEEE---------EEEEEE--HHHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH---------HHHH------------HHHHHHHHHHHH--------HHHHHHHHHHHHH-------------------------------------------HHHHH-HHH---------------HHHHH--- CPSF6_1 consensus MYAVYKQAHPPTGLEFSMYCNFFNNSERNLVVAGTSQLYVYRLNRDAEALTKNDRSTEGKAHREKLELAASFSFFGNVMSMASVQLAGAKRDALLLSFKDAKLSVVEYDPGTHDLKTLSLHYFEEPELRDGFVQNVHTPRVRVDPDGRCAAMLVYGTRLVVLPFRRESLAEEHEGLVGEGQRSSFLPSYIIDVRALDEKLLNIIDLQFLHGYYEPTLLILFEPNQTWPGRVAVRQDTCSIVAISLNITQKVHPVIWSLTSLPFDCTQALAVPKPIGGVVVFAVNSLLYLNQSVPPYGVALNSLTTGTTAFPLRTQEGVRITLDCAQATFISYDKMVISLKGGEIYVLTLITDGMRSVRAFHFDKAAASVLTTSMVTMEPGYLFLGSRLGNSLLLKYTEKLQEPPASAVREAADKEEPPSKKKRVDATAGWSAAGKSVPQDEVDEIEVYGSEAQSGTQLATYSFEVCDSILNIGPCANAAVGEPAFLSEEFQNSPEPDLEIVVCSGHGKNGALSVLQKSIRPQVVTTFELPGCYDMWTVIAPVRKEEEDNPKGEGTEQEPSTTPEADDDGRRHGFLILSREDSTMILQTGQEIMELDTSGFATQGPTVFAGNIGDNRYIVQVSPLGIRLLEGVNQLHFIPVDLGAPIVQCAVADPYVVIMSAEGHVTMFLLKSDSYGGRHHRLALHKPPLHHQSKVITLCLYRDLSGMFTTESRLGGARDELGGRSGPEAEGLGSETSPTVDDEEEMLYGDSGSLFSPSKEEARRSSQPPADRDPAPFRAEPTHWCLLVRENGTMEIYQLPDWRLVFLVKNFPVGQRVLVDSSFGQPTTQGEARREEATRQGELPLVKEVLLVALGSRQSRPYLLVHVDQELLIYEAFPHDSQLGQGNLKVRFKKVPHNINFREKKPKPSKKKAEGGGAEEGAGARGRVARFRYFEDIYGYSGVFICGPSPHWLLVTGRGALRLHPMAIDGPVDSFAPFHNVNCPRGFLYFNRQGELRISVLPAYLSYDAPWPVRKIPLRCTAHY VAYHVESKVYAVATSTNTPCARIPRMTGEEKEFETIERDERYIHPQQEAFSIQLISPVSWEAIPNARIELQEWEHVTCMKTVSLRSEETVSGLKGYVAAGTCLMQGEEVTCRGRILIMDVIEVVPEPGQPLTKNKFKVLYEKEQKGPVTALCHCNGHLVSAIGQKIFLWSLRASELTGMAFIDTQLYIHQMISVKNFILAADVMKSISLLRYQEESKTLSLVSRDAKPLEVYSVDFMVDNAQLGFLVSDRDRNLMVYMYLPEAKESFGGMRLLRRADFHVGAHVNTFWRTPCRGATEGLSKKSVVWENKHITWFATLDGGIGLLLPMQEKTYRRLLMLQNALTTMLPHHAGLNPRAFRMLHVDRRTLQNAVRNVLDGELLNRYLYLSTMERSELAKKIGTTPDIILDDLLETDRVTAHF CPSF1_1 sequence --EEEEEEE------EEEEEEEE-----EEEEE---EEEEEEEE---------------------EEEEEEEEEEEEEEEEEEEE-------EEEEEE---EEEEEEEE-----EEEEEEEEE----------------EEEE-----EEEEEEE--EEEEEEEE---HHHH----------------EEEE---------EEEEEE--------EEEEEEEE-------EEEEEEEEEEEEEEEE---EEEEEE------------EEEE-----EEEEEEE-EEEEEE-----EEEE-------------------EEEEEEEEEEEEE--EEEEEE----EEEEEEEE---EEEEEEEEEE--------EEEEE---EEEEEEEE--EEEEEEEE--------HH------------------------------------HH-------------EEEEEEEEEE-------EEE-------------------EEEEEE-------EEEEE-----EEEEEEE-----EEEEEE----------------------------------EEEEEEE--EEEEEE--EEEEE----------EEEEEEE----EEEEEE---EEEEE----EEEEE------EEEEEE---EEEEEEE--EEEEEEEEE------EEEEE-----------EEEEEEEEE----EE----------------------------------HHH------------HH----------------------EEEEEEE---EEEEEE-----EEEEE-------------------------HHHHH-------EEEEEEEE--------EEEEEE--EEEEEEEEE----------EEEEEEE-------------------------------EEEEEEEE-----EEEEEE-----EEEEEE----EEEEE------EEEEE----------EEE- CPSF1_1 psipred ---EEE--------EEEEEEEEE-----EEEEEE--EEEEEEEE--------------------EEEEEEEEEEEEEEEEEEEEEE------EEEEEE---EEEEEEE------EEEEEEEEE----------------EEEE-----EEEEEE---EEEEEEEE----------------------EEEEEE---------EEEEEEE------EEEEEE---------EEEE--EEEEEEEEE-------EEEEE----------EEE-------EEEEEE-EEEEEE-------EEE------------------EEEEEE-EEEEE---EEEEEE----EEEEEEEE----EEEEEEEEE--------EEEEE---EEEEEE-----EEEEEE---------------------------------------------------------------EEEEEE-------------------------------EEEEEEE-----HHHHHHHH----EEEEEEE------EEEEEE--------------------------------EEEEEEE---EEEEEE--EEEEE----------EEEEEE----EEEEEEE----EEEE----EEEEE------EEEEEE---EEEEEE---EEEEEEE-----------------------EEEEEEEEE-------------------------------------------------------------------------------EEEEEEEE---EEEEEE-----EEEEEE-------------------------------------EEEEEE---------EEEEEE---EEEEEEE----------EEEEEEEE----------------------------------EEEEE------EEEEEE-----EEEEE----EEEEE------EEEE------------EE- CPSF1_1 prof --HHHHH-----HHHHEEEEE-------EEEEE---EEEEEEEE--------------------EEEEEEE-----EEEEEEEEE------EEEEEE----EEEEEE--------EEEEEEEE----------------EEEEE----EEEEEE---EEEEEE--------------------------E--------------EEEE-------EEEEEE---------EEE----EEEEEEEE--------EEEE----------E--------EEEEE---EEEEE-------EEE-------------------EEEE---EEEEE---EEEEEE----EEEEEEEE---EEE-------------EEEEEE----EEEEEEE---EEEEEEE---------------------------------------------------------------EEEEEEEEE-------EEEEE----------------EEEEEEE------EEEEEE-----EEEEEEE-----EEEEEE----------------------------------EEEEEE---EEEEEE-----E-----------EEEEE------EEEEEE---EEEE----EEEEEE------EEEEEE---EEEEEE----EEEEEEE------EEEEE------------EEEEEEEE-----EEE------------------------------------------------------------------------EEEEEEE----EEEEE----EEEEEE-------------------------------------EEEEEEE--------EEEEEEE---EEEEEE------------EEEEEE------------------------------------EEEE------EEEEEE---EEEEEEE----EEEEE------EEEE------------E-- CPSF1_1 jnet -EEEH--------EEEEEEEEE------EEEEE---EEEEEEE---------------------EEEEEEEEE----EEEEEEE--------EEEEEE---EEEEEEE------EEEEEEEE-----------------EEEE-----EEEEEE---EEEEEEE------HH-----------------EEE---------EEEEEEEE-------EEEEEE--------EEE----EEEEEEEE---------E------------EE--------EEEEE--EEEEE-------EEE-------------------EEEEEEEEEEE----EEEEEE----EEEEEEEE----EEEEEEEEE--------EEEEE---EEEEEE-----EEEEEE----------------------------------------------------------------EEEEE----------EEEE-------------------EEEEE------EEEEE------EEEEEEE-----EEEEEE----------------------------------EEEEE-----EEEE------------------EEEEEE-----EEEEEE---EEEEE----EEEE------EEEEEEE---EEEEEE----EEEEEE----------EEE----------EEEEEEE----------------------------------------------------------------------------------EEEEEE----EEEEEE-----EEEEE-----------------------------------HHHHHHHEE---------EEEEEE---EEEEEEE-----------EEEEEEE----------------------------------EEEE--------EEEEE----EEEEEE----EEEE------EEEEEE----------EEEE CPSF1_1 sable -EEEEEEE-----EEEEEEEEE-----EEEEEE---EEEEEEE----------------------EEEEEEEEEEEEEEEEEEEE------EEEEEEE----EEEEEE------EEEEEEEE----------------EEEEE-----EEEEEE---EEEEEEE---------------------EEEEEEEEEE------EEEEEEEE------EEEEEEE--------------EEEEEEEEEE-------------------EEEEE------EEEEEE--EEEEEE----EEEEE------------------EEEEEEEEEEEE----EEEEEE----EEEEEEE-----EEEEEEEEE-------EEEEEE---EEEEEE----EEEEEEE--------------------------------------------------------------EEEEEEEEEE------EEEEEEE---------------EEEEEEEE-----EEEEEE----EEEEEEEE-----EEEEEE---------------------------------EEEEEE----EEEEEE----EEEE--------EEEEEEE-----EEEEE---EEEEEE---EEEEEE-----EEEEEEE---EEEEEE----EEEEEEE----------EE----------EEEEEEEE-----EEEEE-----------------------------------------------------------------------EEEEEE----EEEEEE----EEEEEE-------------------------------------EEEEEEEE-------EEEEEEE---EEEEEEEE----------EEEEEEE--------------------------------EEEEEEE------EEEEEE----EEEEEE----EEEEEE----EEEEEEEE-------EEEE- CPSF1_1 proteus ---EEE--------EEEEEE--------EEEEEE--EEEEEEE-------E------------EEEEEEEEE---EEEEEEEEE--------EEEEE----EEEEEEE-------EEEEEEH-----------------EEEE-----EEEEEEE--EEEEEE---H---------------------EEE-HHH-------HEHHHHH------EEEEEEE--------EEEEEEEEEEEEEEEE-------EE-----------EEEE------EEEEEEEEEEEEE-------EEEE-------------------EEEEEEEEE-----EEEEE-----EEEEEEEE---EEEEEEEEEE-------HHEEEE---EEEEEE-----EEEEEE-------HHHHHHH-------HHH----------------------------------EEE--EEEEEHHHH------E---------HHH----------EEEEE--------EEEEE-----EEEEEE-------EEEEE----------------------------------EEEEEEE--EEEEE---EEEEEE---------EEEEEE-----EEEEE----EEEE----EEEE-------EEEEEEE---EEEEEEE--EEEEEEEE--------EEEEE----------EEEEEEEE-----EEEE-----------------H-------------HHHH------------HHHHHH------------------EEEEEEE---EEEEEE----EEEEEE--------EEE---------HHHHHHHHHHH------EEEEEEEE--------EEEEEE--EEEEEEE------------EEEEEE---------------------------------EEEEEEE------EEEEE-----EEEEEE-----EEEE-------H-------------EEE- CPSF1_1 sspro4 --EEEEEE-----EEEEEEEEE------EEEEEE--EEEEEEEE--------------------EEEEEEEEEE--EEEEEEEEE------EEEEEEE---EEEEEEEE-----EEEEEEEE-----------------EEEE-----EEEEEEE--EEEEEE-------------------------EEEEE--------EEEEEEE-------EEEEEEE------HHHHEEE-EEEEEEEEEE---EEEEEEEEE---------EEE------EEEEEE--EEEEEE-----EEEE-------------------EEEEEEEEEEEE---EEEEEE----EEEEEEEE---EEEEEEEEEE--------EEEEE---EEEEEE----EEEEEEEE-----------------------HHH------------------------------------EEEEEEEEE------EEEEEE------HHH--------EEEEEEE-----EEEEEE-----EEEEEEE-----EEEEEE----------------------------------EEEEEE---EEEEEE---EEEEE---------EEEEEEE----EEEEEE--EEEEEE----EEEEE-----EEEEEEEE--EEEEEEE--EEEEEEEE-------EEEEE-----------EEEEEEE-----EEEE------------------------------------------------------------------------EEEEEEE---EEEEEE----EEEEEE--------EE---------------------------EEEEEEEE-------EEEEEEE---EEEEEEEE----------EEEEEEE----E-----------------------------EEEE--------EEEEE----EEEEEE-----EEEE------EEEE------------EE- CPSF1_1 psspred -EEEEEEE-------EEEEEEE-----EEEEEE---EEEEEEEE---HHH---------------EEE-EEEEE--EE-EEEEEE------EEEEEEE---EEEEEEEE----EEEEEEEEE-----------------EEEEE----EEEEEEE--EEEEEE-----HHHHHHHHH----------EEEEE---------EE-EEEEE------EEEEEEE--------EEEEEEEEEEEEEEE-----------EE---------EE--------EEEEE--EEEEEE------EEE-------------------EEEEEEEEEEEE---EEEEEE---EEEEEEEEE--EEEEEEEEEEE--------EEEEE---EEEEEEEE--EEEEEEE-------HHHHHHHHH----HHHHHHHHHHHHH-H-------------EEE-----------EEEEEEE---------------------H---------EEEEEEE------EEEEEE----EEEEEEEE-----EEEEEEE-------------------------------EEEEEEE----EEEEE----EEEE----------EEEEEEE---EEEEEEE---EEEEE---EEEEE------EE-EEEE---EEEEEE---EEEEEEEEE-------EEEEE----------EEEEEEEEE----E----------------------------------HHHHH-----------HHHHH------------------EEEEEEEE---EEEEEE----EEEEEE-------EEE----------HHHHHHHHHH-------E-EEEEEE-------EEEEEEE--EEEEEEEEE---------EEEEEEEE---------------------------------EEEEEE-----EEEEEEE----EEEEEE----EEEEE-----EE-EEE----------EEEE CPSF1_1 spineX --EEEEEE-----EEEEEEEEE------EEEEE---EEEEEEEE-------------------EEEEEEEEEEE--EEEEEEEEE-------EEEEEE----EEEEEE------EEEEEEEEE----------------EEEE-----EEEEEE----EEEEEE-----EEEEEEEE-------EEEEEEEEEE-----EEEEEEEEEE------EEEEEEEE-----EEEEEEEEEEEEEEEEEE--------E-----------EEEEE-----EEEEEEE-EEEEE------EEEE------------------EEEEEEEEEEEEE---EEEEEE----EEEEEEEE----EEEEEEEEE---EEEEEEEEEE---EEEEEEEE---EEEEEEE-------EEEEE------------EE------EEEEEEE------EEEEE----EEEEEEEEEEEEEEEEEEEE--EEEEEEE-----------------EEEEEE------EEEEEE-----EEEEEEE-----EEEEEEE-----EEE--EEEEEEEE--------------EEEEEEE---EEEEEE---EEEEE---------EEEEEEE----EEEEE---EEEEEE---EEEEEE-----EEEEEEE---EEEEEE----EEEEEEE----EEEEEEEEEE--------EEEEEEEEE---EEEEEEEEEEEEE--EEEEE-------------E----EEEEEE-----E------EEEEE----------------EEEEEEE---EEEEEE-----EEEEEE-----EEEEE--------EEEEEEEEEEEEE-----EEEEEEEEE-------EEEEEE---EEEEEEEE---------EEEEEEE-----E----------------EEE--------EEEEEEEE----EEEEEEE----EEEEEE---EEEEEEEEE---EEEE------------E-- CPSF1_1 raptorxss --EEEE-EE----EEEEEEEE-------EEEEE---EEEEEEEE---------------------EEEEEEEEEEEEEEEEEEEE-------EEEEEE---EEEEEEEE-----EEEEEEEE-----------------EEEE-----EEEEEEE--EEEEEEE-----HHHH----HHH-------EEEEEHHH-------EEEEHH--------EEEE------------EEEEEEEEEEEEE-----EEE-------------EEEEE------EEEEE--EEEEEE------EEE-------------------EEEEEEEEEEE----EEEEEE----EEEEEEEE---EEEEEEEEEE--------EEEEE----EEEEE----EEEEEEEEE---------------------------H---------------------------------EEEEEEH--------EEEEEEE-----HHH--------EEEEEE-------EEEEE----EEEEEEEE-----EEEEEE----------------------------------EEEEEE---EEEEEE---EEEE----------EEEEEEE----EEEEEE---EEEEE----EEEEE------EEEEEEE--EEEEEEE--EEEEEEEE-------HHHEE---H---H---EEEEEEEE-----EE-HHHHHH------------------------------E----------------------------------EEEEEEEE---EEEEEE----EEEEEE--------------------HHH--------------EEEEEEEE-------EEEEEEE--EEEEEEEEE-----------EEEEEE-----------------------------------EEE--------EEEEE----EEEEEE----EEEEEE-----EEEE--E--------EEE- CPSF1_1 SPARROW ---EEE-E-----EEEEEEEEE------EEEEEE--EEEEEEE----------------------EEEEEEEEE--EEEEEEEEE-------EEEEEE---EEEEEEEE----EEEEEEEEEE----------------EEEE-----EEEEEE---EEEEEE---------------H---------EEEE---------EEEEEEE--------EEEEEE--------EEEEE--EEEEEEEE-----EEE--------------EEE-------EEEEE--EEEEE------EEEEE------------------EEEEEEEEEEE----EEEEEE----EEEEEEEE---EEEEEEEEEE---------EEE-----EEEEEE----EEEEEE-----------------------------------------------------------------EEEEEEE---------EEE------HHH--------EEEEEE------EEEEEE----EEEEEEEE-----EEEEEE-----------------------------------EEEE----EEEEE-----EEE----------EEEEEEE----EEEEEE--EEEEEE----EEEEE------EEEEEEE--EEEEEEE--EEEEEEEE-------EEEE------------EEEEEEEE-----EE-------------------------------------------------------------------------EEEEEEE---EEEEEE----EEEEEE-------------------------------------EEEEEEEE-------EEEEEEE---EEEEEEEE-----------EEEEE---------------------------------EEEEEEE-----EEEEEEE----EEEEEE----EEEEEE-----EEE------------EEE- CPSF1_1 *SPARROW EEEEEEEE------EEEEEEEEE-----EEEEEHHHHHEEEE--------------------H-EEEEEEEEEEE--EEEHHEEEEE-----EEEEEEEEEEEEEEE----H--EEEEEEEE--H-------------EEEEE-----EEHHHHHHHHEEEEE--HHHHHHH-------H-------EEEEEHHHHHHHHHHHHHEEEE-------HHHHHHHHHHHHHHHHHHHHEEEEEEEEEEHHHHHEEEEEE----------EEE-------EEEEEEEEEEEE-----EEEE-----------------HH-EEEEEHHHHHHE--EEEEEE-----EEEEEEEE----EEEEEEEEE-------EEEEEE----EEEE------EEEEHHHH--------HHH--------------------------------------------------EEEEEEHHHHH------EEEE------HHH--------EEEEEE-------HEEHHH---HHEEEE-------EEEEEEE--------------------------------EEEEEE----EEEEEEHHHHHHHHH--------EEEEEE-----EEEEEE----EEEE--H-EEE-------EEEEEE----EEEEE-----EEEEEE-----HHHHHHHHHHHHHHH---EEEEEEEEE-----EE------------EEEE---HHHHH---------HHHHH----HHH----------------------------EEEEEE----EEEEEE----EEEEEEE---H-HHHHHH--------H-H-------HHHHHHHHHHHHHHHH-------EEEEEE---EEEEE-E----------EEEEEEH--H--EE----------------HHHHHHHHHHHHHHHHHH------EEEEE----EEEEE-----EEEE--EE--EEEEEE-----------EEE CPSF1_1 HMMSTR --EEEEEEE-----EEEEEE--------EEEEEE--EEEEEEE---------------------EEEEEEEEE----EEEEEEE--------EEEEEE---EEEEEEE-------EEEEEEEE---------EEE-----EEE-----EEEEEEE--EEEEEE-----HHHHH--------------EEEEEE---------EEEEEEE------EEEEEE--------EEEEEEEEEEEEEEEEE----EEEEEEEEE-------EEEE-------EEEE----EEEEE-------EEE-----------------EEEEEEEEEE------EEEEEE---EEEEEEEEE----EEEEEEEEEE-----EEEEEE----EEEEE-----EEEEEEE--------HHHHH-----------EEE--------------------EEEE-----------EEEEEEEEEE-----EEEEEEE---HHHHH--------EEEEEEE------EEEEEE-----EEEEEEE-----EEEEEE----------------------------------EEEEEE---EEEEEE--EEEEE----------EEEEEEE----EEEEEE---EEEE---EEEEEE--------EEEEE---EEEEEE----EEEEEEE--------EEEEEE---------EEEEEE----EEEEE----------------------------------HHEE-----------HHHHHH------------------EEEEEEE----EEEEE----EEEEEEE------EEEEE------------HHHHHHH------HEEEEEEE--------EEEEEE--EEEEEEEEE---------EEEEEEE-----E--------------------------EEEEEEEEEE----EEEEEE----EEEEEEE---EEEE----------------------EEE- CPSF1_1 porter -EEEEEE-------EEEEEEE-------EEEEEE--EEEEEEE-----EE--------------EEEEEEEEEE---EEEEEEEE------EEEEEEE---EEEEEEE------EEEEEE-------------------EEEE-----EEEEEEE---EEEEEE----HHHHH--------------EEEEE--E-------HHHHHHH-------EEEEE---------EEEEE-EEEEEEEEEE----E--EEEEE--------E-EE-------EEEEE--EEEEEE-------EE--------------------EEEEEEEEEE----EEEEEE----EEEEEEEE--EEEEEEEEEE---------EEEEE---EEEEE-----EEEEEEE-------HHHHHEH--------HHHHHHHHH-----------------EEE-------------EEHHHHHHH-------EEE-------HHH-------EEEEEEE------EEEEEE-----EEEEEEE-----EEEEEE---------------------------------EEEEEE----EEEEE---EEEE-----------EEEEEE-----EEEEE----EEEEE---EEEEE------EEEEEEE---EEEEEE---EEEEEEEE-------EEEEEE----------EEEEEEEE-HHHHH-HHH------------------------------HHHHH-----------HHHHH------------------EEEEEEEE----EEEEE----EEEEEE--------------------HHHHHHHHHH-----HHHEEEEEEE--------EEEEEE---EEEEEEEE---------EEEEEEE-----------------------HHH----------EE--H-H----EEEE-----EEEEEE------EEEE-----E--E-----------E--- CPSF1_1 spine HHHHHHH--------EEEEE---------EEE----EEEEEEE---HHHHHH---------HHHHHHHHHHHHH------HHHHHHH------EEE------EEEEE---------EE----------------------EE-------EEEEEE---EEEE----HHHHHHHH---------------EE-HHHHHHHHHHHHHHHHH-------EEEEE---------EEE-----EEEEE----------EEEEE-------------------EEEEE------------------------------------EEEE------EE----EEEEE----EEEEEEE-----HHHHH-------EEEE--EEE----EEEE------HHHHHHHHHH----HHHHHHHH---------------------------------EE---------HHHHHHHHHH--------------------------------EEEEE-------HHHHHH------EEEEE--------EEEE----------------------------------EEEEE----EEEE---HHHHHH----------EEEE-------EEEE-------------------------EEEE-----EEEEEE----EEEEEE-----------EE-----------EEEEEEE-----------------------------------------HHHHH-----------HHHHHH-------------------EEEEE-----EEEE-----EEEEEE-------EEEE-----------HHHHHHHHH---------EEEE---------EEEEE----HHHHH------------EEEEE------------------------------------HHHHHHH-------EEEE-----EEEE--------------------------------EE- CPSF1_1 nnssp --HHHHHH-----EEEEEEEEEE-----EEEEE---HHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---EEEEEEE------HHHHHHHHHH-HHHH----------EEEE-----EEEEEEE--EEEEEE--HHHHHHHH-------------------HHHHHHHHHHHHHHHHH-------EEEEE--------EEEEEE--EEEEEEEE--------EEEEE------HHHH---------EEEEEE--EEEE--------EEE------------------EEEEE----------EEEEEEE--EEEEEEEEE-HHHHHHHHHHHHHHHHH----EEEE---EEEEE----HHHHHHHHHH-----HHHHHHHHHH------------------------HHHHHHHHHH--------------HHHHHHHH-----------------HHHHH-----EEEEEEE-----------------EEEEEEE------------------------------------------EEEEEEEEHHHHHHHHHHHHHHHHH----------EEEEEEE--EEEEEEE-HHHHHHHH---EEEEEE------EEEEEE----EEEE-----EEEEEEE-----------------------EEEEEEEE----------------------------------------HHHHHH----------HHHHHH------------------EEEEEEE---EEEEEE----EEEEEEE------EEEEE--------HHHHHHHHHHHH--HHHHHHHHHHHH-------EEEEE--HHHHHHHH-----------EEEEEEE-----------------------HHHHHHHHHHHHH-HHHHHHH----EEEE-----EEEEE-HHHHHH--------------------------- CPSF1_1 pssfinder HHHHHHH-------EEEEEEEEE------EEEE----EEHHHH-HHHHHHHHH---------HHHHHHHHH------HHHHHHHHH-------EEE-------EEEE-------HHHHHH-----------EEE-----EEEE------HHHHH----EEEEE---HHHHHHHHHHH---------------HHHHHHHHHHHHHHHH-------EEEEE---------EEHHH----EEEEEE---------EEEEEE-----HHHHH--------EEEEEE-------------------------EE-------EEEEE----------HHHEEE-----EEEEEEE------HHH----HHHHHH-----EE----EEEE------HHHHHHHHHH----HHHHHHHHH---------HHH-------------HHHHHHHHEEEE-------HHHEEHHHH-HHH----------------HHHH--------EEEEEE------HHHHHHH-----EEEE--------HHHHHHHHHH---------------------------EEEEEEE-----HHHHHHHHHHHH----------EEE--------EEEEE----HHH-----EE----------EEEE-----EEEEEE----EEEEEEE-------EEEEEE---------EEEEEE-------EE---------------------------------HHHHHH-----------HHHHH--------------------EEEEE-----EEEE-----EEEEEE------EEEEE-----------HHHHHHHHHH------HHHHH----------EEEEE--HHHHHHH-------------EEEEE-------------------------------------HHHHHHH-----EEEE------EEEE------------------------------EEEE CPSF1_1 sspal HHHHHHHHH----EEEEEEE---------EEEE---EEEEEEEHHHHHHHHH-----HHHHHHHHHHHHH-EEEE--HHHHHHHHHH-HHHHHHHHH-----EEEEEEE-------EEEEEEE-HHHHHHHHHH-----EEEE------------EEEEEEHHHHHHHHHHHHH-----------HHHHHHHHHHHHHHHHH-------------EEEEEEE--------------EEEEEEE----------EEEEEEE--------------EEEEEEEEE--EEEE------EEEEE-----------------EEEEEEE---------EEEEEEE---EEEEEEEE----------HHHHHHHEEEEEEEE----EEEE-----HHHHHHHHHHHHH--HHHHHHHHH-------------------------HHHHHHEEEE-----------EEEEEEE-----------------HHHHHHHHH-----EEEEEEE------HHHHHHHHHH--EEEEEEE----HHHHHHHHHHHHHH--------------------------EEEE--------HHHHHHHHHH----------EEEE------EEEEEEE---HHHHHHHHHHEEEEE-----EEEEEEE--EEEE------EEEEEEE-----------------------EEEEEEE-----EEEE------HHHHH---------------------HHHHH----------------------------------EEEEEEE--------------EEEEEEE-------EEEE----------HHHHHHHHHH----HHHHHHHHHH-------EEEEEEE-------------------EEEEEEEE--------------------------------EEEEEEE----EEEEEEEE----EEEEEEE--------EEEE--------------------- CPSF1_1 ssp ----EEE-----------------------EEE-----EEEEE----------------------EEE-EEEEEH---EEEEEE--------EEEEE----EEEEEEEE-----EEEEEHH------------------EEEE-----EEEHHHHH-EEEEEEEE------HH---------------EEEE------------EEEEE-------EEEE----------------------EE--------------------------------EEE-------EEEE-----------------------------EEE---EEEE----EEEEEE----EEEEEEE------EEEEEHH-----------EEEE--EEEEEE----EE-EEEE--------------------------------------------------------------------HE---------EEEEEE-----------------EEEE---------------------EEE--------EE-----------------------------------EEEEEEE----EE------EHH-----------EEEEE-------EEEE---EEEEE-----EEEE------EE--EEE---EEEEEE---EEEEEE---------------------------EEEEH--HHHHHEEH------------------------------------------------------------------------EEEE------EEEEE----HEEE-------------------------HHHHHH---------------------------EE---------------------------------------------------------------------------EEE------------------------------EE-------------- CPSF1_1 sspred --EEEEE-------EEEEEEEE------EEEEEE--EEEEEEEE--------------------EEEEEEEEE---EEEEEEEEE-------EEEEEE----EEEEEEE-----EEEEEEEE-----------------EEEE-----EEEEEE----EEEEEE------------------------EE------------EEEEE-----------EEE-----------EE--EEEEEEEE-------EEEE-----------EEEE-------EEEEE--EEEEE------EEE--------------------EEEEEEEEEEE----EEEEEE----EEEEEEEE----EEEEEEEEE--------EEEE-----EEEE------EEEEEEE-------------------HHHHHHHHHH----------------------------------EEE--------------EE------------------EEEEEEE-----EEEEEE-----EEEEEEE-----EEEEEE----------------------------------EEEEE----EEEEE------EE----------EEEEEE-----EEEEEE---EEEEE----EEEE-------EEEEEE---EEEEEE---EEEEEEEE-----EEEEEEE-----------EEEEEE----------------------------------------------------------------------------------EEEEEEE---EEEEEE-----EEEE--------------------------------------EEEEEEEE-------EEEEEEE---EEEEEEEE----------EEEEEE---------------------------------EEEEEEE------EEEEE-----EEEEEE----EEEEE-----EEEEE-----------EEE- CPSF1_1 netsurfp --EEEEEE-----EEEEEEEEEE-----EEEEE---EEEEEEEE---------------------EEEEEEEEEEEEEEEEEEE-------EEEEEEE---EEEEEEE------EEEEEEEE-----------------EEEE-----EEEEEEE--EEEEEEE------------------------EEE-----------EEEEHH-------EEEEEEE---------EEEE--EEEEEEE--------EE---E---------EE--------EEEEE--EEEEE-------EE--------------------EEEEEEEEEEEE---EEEEEE----EEEEEEEE---EEEEEEEEEE--------EEEEE---EEEEEEE----EEEEEE-----------------------HHHHH------------------------------------EEEEEEE-----------E------------------EEEEEE------EEEEEE-----EEEEEEE------EEEEEE---------------------------------EEEEEE----EEEE------E-----------EEEEEE-----EEEEEE--EEEEEE----EEEEE-----EEEEEEE---EEEEEEE--EEEEEEEE---------EEE-----------EEEEEEE-------E-----------------------------------HHH-----------------------------------EEEEEEE----EEEEE----EEEEEE--------E----------------------------EEEEEEE---------EEEEEE---EEEEEEEE----------EEEEEEE----------------------------------EEEE--------EEEEE----EEEEEE----EEEEE-----EEEEEEE---------EEE- CPSF1_1 soprano --EEEEEE------EEEEEEEE------EEEEE---EEEEEEE---------------------EEEEEEEEEE--EEEEEEEEE-------EEEEEE---EEEEEEE------EEEEEEEE-----------------EEEE-----EEEEEEE--EEEEEE-------HH----------------EEEE----------EEEEEE-------EEEEEE---------EEEEE-EEEEEEEEE--------EE-E----------EEE-------EEEEE--EEEEE-------EEE-------------------EEEEEEEEEEE----EEEEEE----EEEEEEEE----EEEEEEEEE--------EEEEE---EEEEEE----EEEEEEE---------------------------------------------------------------EEEEEEEE---------EEE-------H----------EEEEEE------EEEEEE-----EEEEEEE-----EEEEEE----------------------------------EEEEE----EEEEE----EEEE----------EEEEEE-----EEEEEE---EEEEE----EEEEE------EEEEEE---EEEEEE---EEEEEEEE--------EEEE-----------EEEEEEEE-----EE-----------------------------------HH------------------------------------EEEEEEE---EEEEEE----EEEEEE-------------------------------------EEEEEEEE--------EEEEEE---EEEEEEEE----------EEEEEE-----------------------------------EEEEE------EEEEEE----EEEEEE----EEEEE------EEEE-----------EEE- CPSF1_1 consensus MGSGEPNPAGKKKKYLKAALYVGDLDPDVTEDMLYKKFRPAGPLRFTRICRDPVTRSPLGYGYVNFRFPADAEWALNTMNFDLINGKPFRLMWSQPDDRLRKSGVGNIFIKNLDKSIDNRALFYLFSAFGNILSCKVVCDDNGSKGYAYVHFDSLAAANRAIWHMNGVRLNNRQVYVGRFKFPEERAAEVRTRDRATFTNVFVKNIGDDIDDEKLKELFCEYGPTESVKVIRDASGKSKGFGFVRYETHEAAQKAVLDLHGKSIDGKVLYVGRAQKKIERLAELRRRFERLRLKEKSRPPGVPIYIKNLDETINDEKLKEEFSSFGSISRAKVMMEVGQGKGFGVVCFSSFEEATKAVDEMNGRIVGSKPLHVTLGQARRRC PABP-5_1 sequence ------------------EEEE--------HHHHHHHH-----EEEEEEEE---------EEEEEE--HHHHHHHHHH---------EEEEEE--------------EEEE-------HHHHHHHHHH---EEEEEEEE-------EEEEEE--HHHHHHHHHHH-------EEEEEEE------HHHHHH---------EE---------HHHHHHHHH------EEEEEE--------EEEEE---HHHHHHHHHHH---EE--EEEEEEE---HHHHHHHHHHHHHHHHHH---------EEEE-------HHHHHHHH-----EEEEEEEEE----EEEEEEE---HHHHHHHHHHH--EEE--EEEEEEEE------ PABP-5_1 psipred -----------------EEEEE--------HHHHHHHHH----EEEEEEE----------EEEEEE--HHHHHHHHHHH---------EEEEEE---HHH-------EEEE--------HHHHHHHHHH--EEEEEEEE-------EEEEEE--HHHHHHHHHHH---EE---EEEEEEE---HHHHHHH---HHHH--EEEEE-------HHHHHHHHHH---EEEEEEEEE-------EEEEE---HHHHHHHHHHH--------EEEEE--HHHHHHHHHHHHHHHHHHHHHHHHH---EEEEE-------HHHHHHHHH----EEEEEEEE-------EEEEEE--HHHHHHHHHHH---------EEEEHHHHHH-- PABP-5_1 prof ------------------EEEE--------HHHHHHHHHH---EEEEEEE----------EEEEE-------HHHHHHH--------EEEEEEE------------EEEEE--------HHHHHHHHHHHHHH--EEEE------EEEEEEE-----HHHHHHHHHHH-----EEEE----------------------EEEEE-------HHHHHHHHHHH---EEEEEEE--------EEEEEE-----HHHHHHHH--------EEEEE--------HHHHHHHHHHHHHHHHHHHHH-EEEEE--------HHHHHHHHH---EEEEEEEE-------EEEEEEE----HHHHHHHHHHHHH----EEEEEE------ PABP-5_1 jnet ------------------EEEE--------HHHHHHHHHH---EEEEEEEE---------EEEEEE--HHHHHHHHHHH--------EEEEEE------------EEEEEE-------HHHHHHHHHH---EEEEEEEE-------EEEEEE--HHHHHHHHHHH---E----EEEEEE--------------------EEEE--------HHHHHHHHHH---EEEEEEEE-------EEEEEEE--HHHHHHHHHH---------EEEEEE--------------HHH-----------EEEEEE-------HHHHHHHHHH---EEEEEEE--------EEEEEE--HHHHHHHHHH----EE---EEEEEE------- PABP-5_1 sable ------------------EEEEE-------HHHHHHHHHHH-EEEEEE--EEE-------EEEEEE---HHHHHHHHHH--EE---EEEEEEE-------EEEE--EEEEE-------HHHHHHHHHH-EEEEEEEEE-E------EEEEEE--HHHHHHHHHHH--------EEEEE-EE-----------------EEEEEE-------HHHHHHHHH----EEEEEEEEE---EE---EEEEE--HHHHHHHHHHH--------EEEEEEE----------------------------EEEEE-------HHHHHHHHHHH--EEEEEEE--------EEEEEEE-HHHHHHHHH----------EEEEEEE------ PABP-5_1 proteus -----------H------EEEEE-------HHHHHHH-------EEEEEEE-----------EE----HHHHHHHHHHH--HHH----EEEEE----HHH------EEEEE-------HHHHHHHHH----EEEEEEEE--------EEEE---HHHHHHHHHHH--------EEEEE----HHHHHHHHHHHHH-----EEEE-------HHHHHHHH-------EEEEEE----------EE----HHHHHHHHHHH---------EEHHHHHHHHHHHHHHHHHHHHHHHHHH-------EEEEE------HHHHHHH------E-E-HEEE---------EEE---HHHHHHHHHHH---E-----HHHHHHHHHH-- PABP-5_1 sspro4 ------------------EEEE--------HHHHHHHHHHH--EEEEEEEE--------EEEEEE---HHHHHHHHHHH--EEE--EEEEEEE-------------EEEE--------HHHHHHHHHHH--EEEEEEEE------EEEEEEE--HHHHHHHHHHH--EEE--EEEEEE-------HHHHHH--------EEEE--------HHHHHHHHHH---EEEEEEEE-------EEEEEE---HHHHHHHHHHH--EEE--EEEEEE-------HHHHHHHHHHHH-----------EEEE--------HHHHHHHHHH---EEEEEEEE------EEEEEEE--HHHHHHHHHHH--EEE--EEEEEEE------- PABP-5_1 psspred -----------------EEEEE--------HHHHHHHHHHH----EEEEEE---------EEEEE---HHHHHHHHHHH-------EEEEEE--------------EEEE--------HHHHHHHHHHH--E-EEEEEEE------EEEEEE--HHHHHHHHHHHH--E---EEEEEE----HHHHHHHHHHHH-----EEEE--------HHHHHHHHHHH--E-EEEEEE-----E--EEEEE---HHHHHHHHHHHH--EE--EEEEEE----HHHHHHHHHHHHHHHHHHHH------EEEE--------HHHHHHHHHHH--E-EEEEEEE------EEEEE---HHHHHHHHHHH--EEE---EEEEEEEE----- PABP-5_1 spineX -----------------EEEEE--------HHHHHHHH-----EEEEEE-----------EEEEEE--HHHHHHHHHH---------EEEEEE-------------EEEE--------HHHHHHHHHH---EEEEEEEE-------EEEEEE--HHHHHHHHHHH---EE---EEEEEE--------------------EEEE--------HHHHHHHH-----EEEEEEE---------EEEEEE--HHHHHHHHHH---EEE--EEEEEE------------------------------EEEE--------HHHHHHHE-----EEEEEEE--------EEEEEE--HHHHHHHHHH---EEE---EEEEEE------- PABP-5_1 raptorxss ------------------EEEEE-------HHHHHHHHH----EEEEEEEE---------EEEEEE--HHHHHHHHHHH--EEE---EEEEEE------------EEEEEE---H---HHHHHHHHHHH--EEEEEEEEE------EEEEEE--HHHHHHHHHHH--EEE----EEEEE---------H---------EEEEEE-------HHHHHHHHHH---EEEEEEEE------EEEEEEEE--HHHHHHHHHHH---EE--EEEEEE--------HHHHHHH---------------EEEEE-------HHHHHHHHH----EEEEEEEE-------EEEEEE--HHHHHHHHHHH--EEE--EEEEEEEEEE---- PABP-5_1 SPARROW ------------------EEEEE-------HHHHHHHHH----EEEEEEEE---------EEEEEE--HHHHHHHHHHH--EEE--EEEEEEEE-------------E--E-------HHHHHHHHH-----EEEEEEE-----E-EE-EEE--HHHHHHHHHHH---EE---E-EEEE--------------------EEEEE-------HHHHHHHHH----EEEEEEEE--------EEE-E---HHHHHHHHHHH---EE--EEEEEEE------HHHHH------------------EEEEE-------HHHHHHHHH----EEEEEEE--------EEEEEE--HHHHHHHHHHH---EE--EEEEEEEEEE---- PABP-5_1 *SPARROW ----------------EEEEEEEE------HHHHHHHHHHH--EEEEEEEE------EE--EEEEEE-HHHHHHHHHHH--EEE----EEEEEEE--H-HHH---EEEEEE-HHHHH-HHHHHHHHHHHEEEEEEEEEE------EEEEEEEEEHHHHHHHHHHE---EE---EEEE-----HHHHHHHHHHHHHHHHHEEEEE-------HHHHHHHHHHH-EEEEEEEEE-----EE---EEEEE-HHHHHHHHHHH---EE---EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH---EEEEE---H---HHHHHHHHHHHEEEEEEEEEHH-------EEEEEE-HHHHHHHHHHH---EEEE---HHHHHHHHHHH PABP-5_1 HMMSTR ------------------EEEEE-------HHHHHHHHHHH--EEEEEEEE------EEEEEEEEE--HHHHHHHHHHH---EE--EE-EEEE-----HHHH----EEEEE-------HHHHHHHHH----EEEEEE----------EEEEE--HHHHHHHHHH----EE--EEEEEEE--------------------EEEEE-------HHHHHHHHHH---EEEEEEEE-----EEEEEEEEE--HHHHHHHHHHH---EE--EEEEEEE---------HH------------------EEEEE-------HHHHHHHH-----EEEEEEEE-----EEEEEEEE--HHHHHHHHHHH---E----EEEEEE------- PABP-5_1 porter -----------------EEEEEE-------HHHHHHHHHH---EEEEEEEE---------EEEEEE--HHHHHHHHHHH---EE---EEEEE--------------EEEEE-------HHHHHHHHHHH--EEEEEEEE------EEEEEEE--HHHHHHHHHHH--EEE---EEEEE------HHHHHHHHH-----EEEEEE-------HHHHHHHHHH----EEEEEEE-------EEEEEEE--HHHHHHHHHHH--EEE--EEEEEEE----HHHHHHHHHHHHHHHHH--------EEEEE-------HHHHHHHHH----EEEEEEEEE-----EEEEEEE--HHHHHHHHHHH--EEE---EEEEEE-E----- PABP-5_1 spine ------------HHHHHHHH---------HHHHHHHH--------EEE-----------------------HHHHH-------------EEE---------------EEE---------HHHHHHHH-------EEEEE-------EEEEEE--HHHHHHHHHH---------EEEEE------HHHHHHH------EEEEEE--------HHHHHHHHHH------HHHHHH--------EEEEE--HHHHHHHHHHH--------EEEE---HHHHHHHHHHHHHHHHHHH----------EEE---------HHHHHHHHH-----HHHHHHHH------EEEEE--HHHHHHHHHHH----------EEE-------- PABP-5_1 nnssp --------------EEEEEEEEE-------HHHHHHHHHHH--EEEEEEEE---------EEEEEE--HHHHHHHH-------------EEEE-----HHHH----EEEEE-------HHHHHHHHHHH--EEEEEE----------EEEEE--HHHHHHHHHHHH------EEEEEEE---HHHHHHHHH-----EEEEEEEE-------HHHHHHHHHHH----EEEEEE--------EEEEEE--HHHHHHHHHHH--------EEEE---HHHHHHHHHHHHHHHHHHHHH-------EEEEE-------HHHHHHHHHHH--HHHHHHHHHH----EEEEEEE--HHHHHHHHHHH---------EEEEE------- PABP-5_1 pssfinder -----------HHHHHHHHH-------HHHHHHH---------EEEEEEE-----------EEEEEE-----HHHHHHH---EE-----EEEE----HHHHH-----EEE--------HHHHHHHH-----EEEEEEEE--------EEEEE--HHHHHHHHHH----EE---EEEE--EE--HHHHHHHHHH---EEEEEHHH-------HHHHHHHHHH------HHHHHH---------EEEE--HHHHHHHHHHH-------EEEEE--HHHHHHHHHHHHHHHHHHHHH---------EEHHHHHH---HHHHHHHHHH-----HHHHHHHHH-----EEEE---HHHHHHHHHH----EE-----EEEHHHHHHHH PABP-5_1 sspal -----------HHHHHHHHHEEE-------HHHHHHHHH----EEEEEEE---EEEE-----------HHHHHHHHH--------------------HHHHH------HHHHHHHHHHHHH----------EEEEEEEE-------EEEEHHHHHHHHHHHHHHH---------EEEEEEEEHHHHHHH-------EEEEEEEE-----HHHHHHHHH-------EEEEEEE-----------HHHHHHHHHHHHHHHHH--------HHHHHHHHHHHHHHHHHHHHHHHHHH-------EEEEE---HHHHHHHHHH----------HHHHHHHHH----EEEEEEE--HHHHHHHHHH--EEEE---EEEEE------- PABP-5_1 ssp ------------------EEEEE-------HHHHHHHHHHH--EEEEEEEEE-------EEEEEEE--HHHHHHHHHHH-------EEEEEEE-------------EEEEE-------HHHHHHHHHHH--EEEEEEEEE-----EEEEEEE--HHHHHHHHHHH--------EEEEEE--------------------EEEEE-------HHHHHHHHHH---EEEEEEEE-------EEEEEEE--HHHHHHHHHHH--------EEEEEE-----------------------------EEEEE-------HHHHHHHHHH-----EEEEE-------EEEEEEE--HHHHHHHHHHHH--EE--EEEEEEE------- PABP-5_1 sspred ------------------EEEEE-------HHHHHHHHHH---EEEEEEEE---------EEEEE---HHHHHHHHHHH--------EEEEE--------------EEEEE-------HHHHHHHHHH----EEEEEEE-------EEEEEE--HHHHHHHHHHH---E----EEEEEE--------------------EEEEE-------HHHHHHHHHH---EEEEEEEE--------EEEEE---HHHHHHHHHHH---EE--EEEEEE--------HHHHHHHHHHH-----------EEEE--------HHHHHHHHH----EEEEEEEE------EEEEEEE--HHHHHHHHHHH---EE---EEEEEEE------ PABP-5_1 netsurfp ------------------EEEE--------HHHHHHHHH----EEEEEEE----------EEEEE---HHHHHHHHHHH---E----EEEEE--------------EEEE--------HHHHHHHHHH----EEEEEEE--------EEEEE--HHHHHHHHHHH---EE---EEEE----------------------EEEE--------HHHHHHHHH----EEEEEEEE--------EEEEEE---HHHHHHHHHH---EE---EEEE---------HHHHHHHHHHH----------EEEEE--------HHHHHHHHHH---EEEEEEEE-------EEEEEE--HHHHHHHHHHH---EE---EEEEEE------- PABP-5_1 soprano ------------------EEEEE-------HHHHHHHHHH---EEEEEEEE---------EEEEEE--HHHHHHHHHHH--------EEEEEE-------------EEEEE-------HHHHHHHHHH---EEEEEEEE-------EEEEEE--HHHHHHHHHHH---E----EEEEEE------HHHH----------EEEEE-------HHHHHHHHHH---EEEEEEEE--------EEEEEE--HHHHHHHHHHH---EE---EEEEE-------HHHHHHHHHHHHHH---------EEEEE-------HHHHHHHHHH---EEEEEEEE-------EEEEEE--HHHHHHHHHHH---EE---EEEEEE------- PABP-5_1 consensus PPPYDMKAYYGRSVDFRDPFEKERYREWERKYREWYEKYYKGYAAGAQPRPSANRENFSPERFLPLNIRNSPFTRGRREDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQKVKSVTV RBBP6_1C sequence -------------------HHHHHHHHHHHHHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHH---------------HHHHH----------------------------------------------------------------------------HHHH---------------------------------HHHHH----------------------------------------------HHHH----------HHHHHH----------------HHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHH--------------------HHHHH---------------------------------------------------------------HHHHHHHHHH----HHHHH--------------------------------------HHHHHHHHHHHHHHHHHH--------------HHHHHHHHHHHHH-------HHHHHH----HHH------ RBBP6_1C psipred -----------------------------HHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_1C prof --------------------------HHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_1C jnet ----------------------HHHHHHHHHHHHHHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_1C sable --------------------HHHHHHHHHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHH--------------------------------------------- RBBP6_1C proteus -----------------------HHHHHHHHHHHHHHHH--------------------HHHH-----------------------------------------------------------------------EE------------HHH-------------------------------------------EEE--------------E----------------------------------------------------------------------------------------------------------------------------------------------------------------E--------------------------------EEE-----------------------------------------EEEE------------------------------------------------------EEEEEE-------------------------------------------------EEE----------------EE------------------------------HHH-------------HHHH--------------------------------------EEEE----------------------------------------------------------------------------------------------EEEE----------------------------------------------------------H-------------------EH---------HH---------------------------------------------------HH---HH------EE---------------------EEE------------------------------------ RBBP6_1C sspro4 ----------------------------HHHHHHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_1C psspred ---HHHHHH----------HHHHHHHHHHHHHHHHHHHHHHH---------------------------------------------------------------------------------------HHHHHHH----HHHHH---HHHHHHHH---------------H----------------------------HHHHHHHH-------HHH-------------------------HHHH----------HHHH-------------------------HHH--HHHHHH-----HHHHHH---H---HHHHHHHHHHHHHH----------HHHHHHHHHHHHHH-----HHHH-------HHHH----------HHHHHH----HH--------HHHHHHHHHH----------------HHH----HHHHHHHHHHHHHH------------------------------H--HHHHHHHHHHHHHH-------HHHHHHHH-----------HHHHHHHHH-----------------------------------HHHHHHH-----HHHHHHHHHHH-----------------HHHH--HHHH------HHHHHHHHHHHHH---------H-----H------------------------HHHHHHHHHHHHHHHHHHH----------HHH-----HHHH-----------------------------------HHHH---------HHHHHHHHHHHHH----------------HHHHHHHH---------------------------HHHHHH-------------HHHHHHHH------HHHHHHHHHHHHHHHHHHHHH-------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------- RBBP6_1C spineX ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ RBBP6_1C raptorxss -----------------------HHHHH-------HHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHH-----------------------------------------------------HH------HHH----------------------------------- RBBP6_1C SPARROW ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ RBBP6_1C *SPARROW -----HH-EE-----------HHHHHHHHHHHHHHHHHHHHHH---------------------------------------------------------------------------------------------------------HHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------H---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHH-------------------HH-----HH--H-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HH--------------------------------HH-------------------H-------HHHHHHHHHHHHHHH---------------------------------------------HH-------HHHHHHHHH-HHHHH-------HHHHHHHHHHHHHH--------HHHHH----H---EEEE RBBP6_1C HMMSTR --------------------HHHHHHHHHHHHHHHHHHHHH-H--------------------------------------------------------------------------------HHHHHHHHHHHHHHHHH--------HHHHHHH---------------HHHH--------------------------HH--------------------------------H----------------------HH-----------------HHH----------------------------------------------------------HHHH-------------------------------------HH------------------------HHHHHHHH-----------------------------HHHHHHH---------------------------------------------HHH------------HHH-------------HHHHH-----------------------------------------H-----HHHHHH-------------------------HHH---HHHHH-----------HHHH-------------HHH-HHHH-----HHHH-----HH-------HHH--HHHHHHHHHHHHH-----HHHHH---------HHH------HHHHHH------------------------------------HHHHHHHHHH------HHHHHHH----HHHHHHHHHHHH----------HHHH-----HHH---HHHHHH-----------------HH--HHHHHHHHHHHHHHH-----HHH----HHHHHHH---------------------------H----------------------------------------HHHH-----------HHHHHH----------- RBBP6_1C porter ----HHHHH----------HHHHH--HHHHHHHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHH-------HHHH---------------------------------------------------------------------------------------------------------HHH---------------------------------------------------------------------------HHHH-H--------------------------------------------------------------------------------------------------------------------------------------------------------------H-H----HHHH----------HHHHHH-----------------HHHH------------ RBBP6_1C spine ---------------------HHHHHHHHHHHHHHHHHHHH-------------------------------------------------------------------------------------------HHHHHH----------HHHHHHHH---------------EEEE------------------EEEE------------------------------------------------------------HHHHH-------------------------HHHHHHHHH--------HHHHHHH-------HHHHHHHHHH---------------HHHHHHHH-----------------EEEE-------------------------EEE------EEE---------------------HHHHH-------------EEEEE--------EEEEE---------------------HHHHHHHHHH----------EEEEEE----------HHHHHH---------------------------EE----------HHHHHHHHHHHHHHHHHHHH-----------------HHHHHH----------------------------------------------------------------------------HHHHHHH------------------------------------------------------------------------HHHHHHHHH---------EEEEE-----HHHHHHH----------------------------------------------EEEE---------HHHHHHHHHHHHHH-----EEEEEE--------------------------------------HHHHHHHHHHHHHHHHHHHHHHHH----EEE----HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE RBBP6_1C nnssp ------------------HHHHHHHHHHHHHHHHHHHH---------------------HHH--------------------------------------------------------------------------------------HHHHHHHHH-------------EEEEEE------------------------HHHHHHH-------------------------------------------------------------------------------------------------HHHHHHH------------HHHHHH-----------------------------------EEEEEEEEEE----------------------EEEEE--HHHEEEE-------------------HHHHHHHHHHHHHHHH---EEEEEEEEE--EEEEEE---------------------HHHHHHHHHH--------HHHEEEEEE-------------------------------EEEE-------------------HHHHHHHHHHHHHHHHHHHHHH----------------HHHHHHH----------------HHHHHHH---------------------------------------------------------------------------------------------------------------------------------------EEEEEE-------EEEEEE-----HHHHHHHH----------------------------------------------------------HHHHHHHHHHHHHHHHHHHEEEEEEE-----------------------------------HHHHHHHHHHHHHH----------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-- RBBP6_1C pssfinder --------------------HHHHHHHHHHHHHHHHHHHHHHHH---------------------------------EEE--------------------------------HHHHHH-------------HHHHHHH---------------------------------EEEEE----------------EEE---HHHHHHHHH-----------------------EEE-------EE-------------HHHHHH-----------------------------HHHHHHHH-----HHHHHHHHHH----HHHHHHHHHHH--------------HHHHH---------------EE----HHHHH--------------------------HHHHHHHHHHHHH------------------HHHHH--HHHHHHHH----EEEE--------EEE----------------------HHHHHHHHHHH----------EEEEEEE-EEE----HHHHHHHHHHH-----------------------EE----------HHHHHHH----HHHHHH------------------HHH-HHHHH-------------HHHHHHHH---------HHHHHHHH-----------------------------------HHHHHHHHH--------------------HHH---------------------------EEEE--------HHH--------HHHHHHHHH--------EEEEE-----------------------------------HHHHHHHH---------------EEE----------HHHHHHHHHHHHH------EEE-----------------------------------------HHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHH-------HHHHHHHHHH-HHHHEEEE RBBP6_1C sspal ----------------HHHHHHHHHHH--HHHHHHHHHH-------------------------------------------------------------------------------------------HHHHHHHHH---------HHHHH------------------EEEE------------------EEEEEEE-------------------------------------------------------HHHHHHHHH----------------EEEE----------------------------------HHHHHHHHHHHH------------HHHHHHHHHH------------EEEEEEE--------------------------EEEE----EEEE--------------------------------------EEEEEEE-------EEEE---------------------HHHHHHHHHHH----------EEEEEEE------------------------------------------EEEE--------HHHHHHHHH--HHHHHHHHH-------------------------------------HHHHHHHHHH------------------------------------------------HHHHHHHHH--------------------------------------------------------------------------HHHHHHHHH--------EEEEEEE--HHHHHHHHHEEEEE---------------------HHHHHHHHH-----------EEEE-----------HHHHHHHHHHH------EEEEEEE-------------------------------------------------------------------------------------HHHHHHHHH---------- RBBP6_1C ssp ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ RBBP6_1C sspred ---------------------------HHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_1C netsurfp -----H-HH------------HHHHHHHHHHHHHHHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_1C soprano ---------------------HHHHHHHHHHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_1C consensus MADGELNVDSLITRLLEVRGCRPGKIVQMTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRFNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVSFTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSEKKAKYQYGGLNSGRPVTPPRTANPPKKR PP-1B_1 sequence -------HHHHHHHHHH-------------HHHHHHHHHHHHHHHHH---EEEE---EEEE------HHHHHHHHHH---------------------HHHHHHHHHHHHH-----EEEE--------------HHHHHHHH--HHHHHHHHHH-----HHEEE---EEEEE---------HHHHH-------------HHHH--------------------EE--HHHHHHHHHH----EEEEE---------------EEEEE------------EEEEEE-----EEEEEE-------------------------------- PP-1B_1 psipred -------HHHHHHHHHHHH-------EE--HHHHHHHHHHHHHHHH----EEE-----EEEE----HHHHHHHHHHH--------EEEE----------HHHHHHHHHHH------EEEEE------HHHHHH--HHHHHHHH-HHHHHHHHHHH----EEEEE--EEEEEE---------HHHHHHH---------------------------------EEEEE-HHHHHHHHHH-----EEHHHHHHHHHHHHHH--EEEEEEE------------EEEEE----EEEEEEE-------------------------------- PP-1B_1 prof -----HHHHHHHHHHHHH------------HHHHHHHHHHHHHHHHH----E-----EEE------HHHHHHHHHHH--------EEEE---------HHHHHHHHHHHHHH----EEEEE----------EEE-HHHHHHHHHHHHHHHHHHHHHH--HHHHH---EEEE-------HHHHHHHH--------------EEEE-----------------EEEEE--HHHHHHHH----EEEHHHHHHHHHHHHHH---EEEEEEE----------HHHHHHHHHHHHHHHHH--------------------------------- PP-1B_1 jnet -------HHHHHHHHHHH------------HHHHHHHHHHHHHHHH----EEEE---EEEE------HHHHHHHHHH--------EEEE---------HHHHHHHHHHHHH-----EEEE-----HHHHHHH---HHHHHH---HHHHHHHHHHHH---HHHH----EEEE----------HHHHHH-------------HHH------------------EEEE--HHHHHHHHHH----EEEEEHHHHH--HHHH----EEEEE------------EEEEEE-----EEEEEE-------------------------------- PP-1B_1 sable -------HHHHHHHHHH-------------HHHHHHHHHHHHHHHHH---EEEE---EEEE-E----HHHHHHHHHHH-------EEE----------HHHHHHHHHHHHHH----EEE-------HHHHHHH-HHHHHHHH--HHHHHHHHHHH-----EEEE---EEEE----------HHHHHH-----------HHHHHHH-EE------EEE------EEE-HHHHHHHHHHH---EEEE--------EEEE----EEEEE------------EEEEEE-----EEEEEE-------------------------------- PP-1B_1 sspro4 -------HHHHHHHHHHHH-----------HHHHHHHHHHHHHHHHH---EEEE---EEEEE-----HHHHHHHHHH--------EEE----------HHHHHHHHHHHHHH---EEEEEE-----HHHHHHH-HHHHHHHHH-HHHHHHHHHHHHH--EEEEE---EEEE----------HHHHHH-----------HHHHHH------------------EEEE-HHHHHHHHHHH---EEEEE-----H-HHEE---EEEEEE-----------EEEEEEE-----EEEEEE-------------------------------- PP-1B_1 psspred -------HHHHHHHHHHHH-----------HHHHHHHHHHHHHHHHH-----E----EEEE-----HHHHHHHHHHHH--------------------HHHHHHHHHHHHHH----EEE-------HHHHHHH-HHHHHHHHH-HHHHHHHHHHHHH--HHHHHH-EEEEE----------HHHHHH------------H---------------------------HHHHHHHHHHH---EEEEHHHHHHH--------EEEEEEE-----------EEEEEEE---EEEEEE----HHHHHHHH--------------------- PP-1B_1 spineX -------HHHHHHHHHH--------EEE--HHHHHHHHHHHHHHHH----EEEE----EEE------HHHHHHHHHH----------------------HHHHHHHHHHH-------EE-----------EE---HHHHHH---HHHHHHHHHHHHH--HHHE---EEEE-----------HHHHHH----------------E------------------EEEE-HHHHHHHHHH---HHHHHHHHHHHH-HHHH---EEEEEEE------------EEEEE----EEEEEEE-------------------------------- PP-1B_1 raptorxss -------HHHHHHHHHH-------------HHHHHHHHHHHHHHHH----EEEE---EEEE------HHHHHHHHHH--------EEEE---------HHHHHHHHHHHHHH----EEEEE-----HHH-EEEE-HHHHHH---HHHHHHHHHHH---EEEEEE--EEEEE----------HHHH--------------HH-E-------------E------EE--HHHHHHHHHHH---EEEE---E-HHHHHHE----EEEEEE----------EEEEEEE----EEEEEEEE------------------------------- PP-1B_1 SPARROW -------HHHHHHHHHH-------------HHHHHHHHHHHHHHHH------EE----EHHHH--H-HHHHHHHHH-----------E-HH------HHHHHHHHHHHHHHH-----EEE-H-H--HHHH-----HHHHHHHH-HHHHHHHHHHHH----HHHH---EEEE----------HHHHHH----------HHHH--------------------------HHHHHHHHHH----EEEE--HHHHHHHHHHH---EEEEEE----------EEEEEEE-----EEEEEEE------------------------------- PP-1B_1 *SPARROW -----H-HHHHHHHHHHHH------EEE--HHHHHHHHHHHHHHHHH---HHHH---EEEEE-E----HHHHHHHHH--------EEEEE-EE-----HHHHHHHHHHHHHH---EEEEEE-------EEEE----HHHHHH--HHHHHHHHHHE----HHHHH-HEEEEEE----HHHHHHHHHHHHHH---------HHHHHHH---H------------EEEEEHHHHHHHHHHH--HEEEEHHEEEE---EEEEHH-EEEEEE------E------EEEE-HHHEEEEEEE----H--------------------------- PP-1B_1 HMMSTR -------HHHHHHHHH--------------HHHHHHHHHHHHHHHHH---EEEE---EEEE-E----HHHHHHHHHHH-------EEE----------HHHHHHHHHHHHHH----EEE-------HHHHHHH-HHHHHHHH--HHHHHHHHHHH-----EEEE---EEEE----------HHHHH------------HHHHHHH-EE------EEE------EEE-HHHHHHHHHHH---EEEE--------EEEE----EEEEE----HHH-----EEEEEE-----EEEEEE-------------------------------- PP-1B_1 porter -------HHHHHHHHHHH------------HHHHHHHHHHHHHHHHH---EEEE---EEEEEE----HHHHHHHHHH--------EEEE--------HHHHHHHHHHHHHHH---EEEEE---------HHH--HHHHHHHH--HHHHHHHHHHHHHHHHHHHH---EEEE----------HHHHHHH-----------EEEEEE------------------EE--HHHHHHHHHH----EEE-E----H--EEEE----EEEEEE-----------EEEEEE----EEEEEEEE----HHHHH---------------------- PP-1B_1 spine -------HHHHHHHHHHH-------EEEE-HHHHH--------------HHHHH--------------HHHHHHHH----------EE-----------HHHHHHHHH--------EEEE--------HHHHH-----------HHHHH------------------EEE--------HHHHHHHHHHH----------------------------------EE---HHHHHHH-----HHHHHHHHHHHH---------EEEE--------------------------EEE---------EE---------------------- PP-1B_1 nnssp -------HHHHHHHHHHH------------HHHHHHHHHHHHHHHHH---EEEE---EEEE------HHHHHHHHHHH-------EEE----------HHHHHHHHHHHHHH----EEEE------HHHHHHH-HHHHHHHH--HHHHHHHHHHHHH---EEEE---EEEE----------HHHHHH-----------HHHHHHH-EE------EEE------EEE-HHHHHHHHHHH---EEEE--------EEEE----EEEE-------------EEEEEE-----EEEEEE------EEEEE--------------------- PP-1B_1 pssfinder -------HHHHHHHHHHH--------HHHHHHHHHHHHHH--HHH---HHHHHHHH-HHH-------HHHHHHHHHH--------EEEEE------HHHHHHHHHHHHH-------EEEE--------HHHHHHH-HHHH-----HHHHHHH-------EEEE----EEE-----------HHHHHHHH--------------------------------EEE---HHHHHHHH----HHHHHHHHHHHHHHHHHHHH---EEEE--------------------HHHH-HHH------HHH------------------------ PP-1B_1 sspal -------HHHHHHHHHH-------EEEEHHHHHHH-EEEE------HHHHHHHHHH-EEEE-------HHHHHHHHH----------------HHHHHHHHEEEEEEEEEEEE----------------------HHHHHHHHHEEEEE----------HHHHHHHHH----------HHHHHHHHHHHH--------EEEEEEE----------------EEEEE-HHHHHHHHHH--HHHHHHHHHHHHH-HHHHHHHHHEEEE-----------------HHHHHHHHHHHHH------------------------------- PP-1B_1 ssp -------HHHHHHHHHHH------------HHHHHHHHHHHHHHHHH----EEE---EEEEE---HHHHHHHHHHHHH------EEEEE----------HHHHHHHHHHH-----EEEEE-------HHHH----HHHHHH---HHHHHHHHHHHHH----EEE--EEEEEE---------HHHHHH---------------HH-------------------EEE-HHHHHHHHHHH--EEEEE---------EEE----EEEEEE----------HEEEEEE-----EEEEEE-------------------------------- PP-1B_1 sspred -------HHHHHHHHHHH------------HHHHHHHHHHHHHHHH-----EE-----EEE------HHHHHHHHHH----------------------HHHHHHHHHHHH------EE----------------HHHHHHH--HHHHHHHHHHHH---HHHH----EEEE----------HHHHH----------------E-------------------EE---HHHHHHHHHH----EEEEHHHHHHHHHHHH----EEEEEE-----------EEEEEE-----EEEEEE-------------------------------- PP-1B_1 netsurfp -------HHHHHHHHHHHH-----------HHHHHHHHHHHHHHHHH---EEE----EEEEE-----HHHHHHHHHH--------EEEE---E------EEEEEEEEEE-HH----EEEEE-----H-H--HH-HHHHHHHH--HHHHHHHHHHHH---EEEEE--EEEEE----------HHHHH-------------E-EEE-------------------EE--HHHHHHHHHH----EEEEEEEEE----EEE---EEEEEEE-----------EEEEEE-----EEEEEE----HH-------------------------- PP-1B_1 soprano -------HHHHHHHHHHH------------HHHHHHHHHHHHHHHHH---EEEE---EEEE------HHHHHHHHHH--------EEE----------HHHHHHHHHHHHHH----EEEE-------HHHHHH--HHHHHHH--HHHHHHHHHHHH---HHEEE---EEEE----------HHHHHH------------HH-H--------------------EEE-HHHHHHHHHH----EEEEHHHHHHH-HHHE----EEEEEE-----------EEEEEE-----EEEEEE-------------------------------- PP-1B_1 consensus MPSSPLRVAVVCSSNQNRSMEAHNILSKRGFSVRSFGTGTHVKLPGPAPDKPNVYDFKTTYDQMYNDLLRKDKELYTQNGILHMLDRNKRIKPRPERFQNCKDLFDLILTCEERVYDQVVEDLNSREQETCQPVHVVNVDIQDNHEEATLGAFLICELCQCIQHTEDMENEIDELLQEFEEKSGRTFLHTVCFY SSU72_1 sequence ------EEEEEE-------HHHHHHHHH----EEEE-----EE-----------------HHHHHHHHHHHHHHHHHH----HHHH--------------------EEEE---HHHHHHHHHHH--------EEEEEEEE----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----EEE--- SSU72_1 psipred -----EEEEEEE-------HHHHHHHHH---EEEE-----EEE-----------------HHHHHHHHHHH-HHHHHH--HHHHHH---------HHHH-------EEEEE-HHHHHHHHHHHHH--------EEEEEEE----HHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHH----EEEEEEE- SSU72_1 prof ------EEEEEE-----HHHHHHHHHHH----EEE-----EEEE---------------HHHHHHHHHHHHHHHHHHH--HHHHHH------------------EEEEEEE--HHHHHHHHHHHH-------EEEEEE------HHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHH-----EEE---- SSU72_1 jnet ------EEEEEEE-----HHHHHHHHHH----EEEE----EEE----------EEEE---HHHHHHHHHHH-HHHHH----HHHHH----------HH------EEEEEE---HHHHHHHHHHHH-------EEEEEEEEE----HHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHH----EEEEEEEE SSU72_1 sable -----EEEEEEE------HHHHHHHHHH--EEEEEE----EEE---------EEE-----HHHHHHHHHHHHHHHHHHH--HHHHH-----------------EEEEEEE---HHHHHHHHHHH-------EEEEEEEEEE---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---EEEEEEE-- SSU72_1 proteus -------EEEEE-------HHHHHHHHH----EEE-----EEE----------E------HHHHHHHHHHH-HHHHHH--HHHHH----------HHHHH----EEEEEE---HHHHHHHHHHH---------EEEEEEEE---HHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHH----EEEEEEE- SSU72_1 sspro4 ------EEEEEE-----HHHHHHHHHHHH---EEEE------E-----------E-----HHHHHHHHHHH-HHHHHHH--HHHHHH-----------------EEEEEE---HHHHHHHHHHHH-------EEEEEEEEE---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---EEEEEEE- SSU72_1 psspred ------EEEEEE-------HHHHHHHHHH--EEEEE----E-EE----------------HHHHHHHHHHH-HHHHHHH-HHHHHHH--------HH-------E-EEEE--HHHHHHHHHHHHH-------EEEEEEE-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----EEE-E- SSU72_1 spineX ------EEEEEE-------HHHHHHHHH---EEEE-----EEE-----------------HHHHHHHHH---HHHHHH--HHHHHH--------HHH---------EEEEHHHHHHHHHHHH----------EEEEEE------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------------ SSU72_1 raptorxss ------EEEEEE------HHHHHHHHHH---EEEEE----EEE---------EE------HHHHHHHHHH--HHHHHH---HHHHH--------------------EEEEE-HHHHHHHHHHHHH------EEEEEEEEEE---HHHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHH----EEEEEE- SSU72_1 SPARROW -------EEEE--------HHHHHHHHH----EEE-----EE-----------E------HHHHHHHHHH--HHHHHH---HHHHH---------HH---------EEEE---HHHHHHHHHHHH-------EEEEEEEE----HHHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHH-----EEEEEE- SSU72_1 *SPARROW ------EEEEEEEE----HHHHHHHHHHH--EEEEE----EEEE---------EEEE---HHHHHHHHHHH---EEE---HHHHHHH---EE--HHHHHHHH--E-EEEE--HHHHHHHHHHHHHHHH-----EEEEE--EE--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---EEEEEEEE SSU72_1 HMMSTR ------EEEEEE-----H-HHHHHHHHH----EEEEE----EEE--------EEE-----HHHHHHHHHH--HHHHHH--HHHHHHHHH-------E---------EEEE--HHHHHHHHHHHH---------EEEEEE-----HHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHH-----EE-EEE-- SSU72_1 porter -----EEEEEEE-------HHHHHHHHH----EEEE-----EE-----------------HHHHHHHHHHHHHHHHHH--HHHHHH---------HHHH-------EEEEE-HHHHHHHHHHHH---------EEEEEEEE---HHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHH----EEEEEE-- SSU72_1 spine ------EEEEEE------HHHHHHHHH----EEE-------EE-----------------HHHHHHHHHHH---------HHHHHH--------------HHHHHHHHHHHHHHHHHHHHHHHH---------EEEEEE--------HHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHH---EEEEEEEEE SSU72_1 nnssp ------EEEEEE-----HHHHHHHHHHH---EEEE-----EEE-----------------HHHHHHHHHHHHHHHHHHHHHHHHHHH-------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---EEEEEEE----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---EEEEEEEE- SSU72_1 pssfinder ------EEEEEE-------HHHHHHHHH---EEEE-----EEE----------------HHHHHHHHHHHHHHHHH----EEE-----------------HHHHHHHHHHHHHHHHHHHHHHHH---------EEEEEEEE-----HHHEEHHH-HHHHHHH---HHHHHHHHHHHHHHHHH---EEEEEEEEE SSU72_1 sspal -----EEEEEEE-------HHHHHHHHH---------EEEEEEEE---------HHHHHHHHHHHHHHHH-------------------------HHHHHHHHHHHHHH---HHHHHHHHHHHH---------EEEEEEE----HHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH--EEEEEEEE- SSU72_1 ssp ------EEEEEEE-------HHHHHHHH----EEE-------------------------HHHHHHHHHHH-HHHHH---HHHHHHH-----------------EEEEEEE-HHHHHHHHHHHH--------EEEEEEEEEE------HHHHHHHHHHHHHHH----HHHHHHHHHHHHHH----EEEEEE--- SSU72_1 sspred ------EEEEEEE-----HHHHHHHHHH----EEE------EE----------EEE----HHHHHHHHHHH-HHHHHH---HHHHH-------------------EEEEEE--HHHHHHHHHHHHH------EEEEEEEE----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----EEEEEE- SSU72_1 netsurfp ------EEEEEE------HHHHHHHHHH----EEEE----EEEE---------EE-----HHHHHHHHHH--HHHHHHH---HHHH------------------EEEEEE--HHHHHHHHHHHHH-------EEEEEEE-----HHHHHHHHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHH-----EEEE--- SSU72_1 soprano ------EEEEEE-------HHHHHHHHH----EEE-----EEE-----------------HHHHHHHHHHH-HHHHHH--HHHHHH------------------E-EEEE--HHHHHHHHHHHHH-------EEEEEEEE----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----EEEEEEE- SSU72_1 consensus MSAGEVERLVSELSGGTGGDEEEEWLYGGPWDVHVHSDLAKDLDENEVERPEEENASANPPSGIEDETAENGVPKPKVTETEDDSDSDSDDDEDDVHVTIGDIKTGAPQYGSYGTAPVNLNIKTGGRVYGTTGTKVKGVDLDAPGSINGVPLLEVDLDSFEDKPWRKPGADLSDYFNYGFNEDTWKAYCEKQKRIRMGLEVIPVTSTTNKITAEDCTMEVTPGAEIQDGRFNLFKVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTASRKANSSVGKWQDRYGRAESPDLRRLPGAIDVIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFLPPPPTVSTAPPLIPPPGFPPPPGAPPPSLIPTIESGHSSGYDSRSARAFPYGNVAFPHLPGSAPSWPSLVDTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQESTEATPAE FIP1L1_1 sequence --HHHHHHHHHHH-----------------------------------------------------------------------------------EEEE---------------------------------------------------------------------------------HHHHHHHHHHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH-----------------HHHHHHHHHHH---------------HHHHHHHHHHHH---------HHHHHHHHHHHHHHHHHHH------------------------------------------------------ FIP1L1_1 psipred --HHHHHHHHHH-------------------------------------------------------------------------------------EE----------------------------------------------------EEEE--------------------------HHHHHHHHHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- FIP1L1_1 prof --HHHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- FIP1L1_1 jnet -----HHHHHHHH----------------------------------------------------------------------------------EEEEE----------------------------------------------------EE-------------------EEEE----HHHHHHHHHHHHHHHHHH------HHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- FIP1L1_1 sable ---HHHHHHHHH------------------------------------------------------------------------------------EEEE---------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH---------------------HHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----------------------------------------------------- FIP1L1_1 proteus ----EEEEEEHEHH-------EHHHH-----EEE----HHHH--HHHH-HHHH---------HHHHHHHH------EE-------------------EEEEE-------------------------E---------------------EEEEE--HHHH-----------HHHHH-----HHHHHHHHHHHHHHHH-----EHHHHH----------------EE----EEEEEEEE---------EE-----------------------------------------------H---------HH-----EEEE-EEEEEEE------------EEEEE----------------------------------------------------------------E------------------------------------------------HHHHHHHHHHHHHHHH-----HHHHHHHHHHHH-------------HHHHHHHHHHH---HHH---HHHHHHHHHHHHHHHH--------------------------------------------------------- FIP1L1_1 sspro4 --HHHHHHHHHHH--------HHHH------------------------------------------------------------------------EE------------------------------------------------------------------------------------HHHHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHH--HHHHHHHH----HHHH---HHHHHH-----------HHHHHH------ FIP1L1_1 psspred --HHHHHHHHHHHH-------HHHHHH---------HHHHHHHHHHHHH-HHHHHHH---------HHHH--------------------------EEEE--------------------------------------E-----------EEEE---HH------------HHH-------HHHHHHHHHHHHHHHHH--HHHHHHHH-----------------------------------H---H------------------------------------------------------------------------------------------EE------------------------------------------------------------------------------------------------------HH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-HH------HHHHHH----- FIP1L1_1 spineX --HHHHHHHHH---------HHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------HHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H----HHHHHHHHHHHH--HHHHH-HHHHHHHHHHHHHHHHHHH--HHH---HHHH--HH--HHHHHHHHHHHH-H---------------------- FIP1L1_1 raptorxss --HHHHHHHHHH----------HH-----------------------------------------------------------------------EEEEEE---------------------------------------------E---EEEEE-HHHH-----------EEEEE-----HHHHHHHHHHHHHHHHH----HHHHHHH----------------------------------------------------------------------------------------------------------H--------------------------------------------------------------------------------------------------------------------------------------------------H--------HHH--------H-HHH-------------HHH------HHH-----------H-----H-H---HHH------------------------------HHHH----------HHHHHH------ FIP1L1_1 SPARROW ----HHHHHHHH----------HHH-------------------------------------------------------------------------------------------------------------------------------------HH------------------------HHHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H------------------------HHHH----H-H-------------------------------------------------------- FIP1L1_1 *SPARROW --HHHHHHHHHHHHHHHHH-HHHHHH---------H------------------------------------------------------------EEEEE---------------------------------------------E----EEE--HHH------------EEHHE-----HHHHHHHHHHHHHHHHHH-----HHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHH---------------------------------HHHHHHH-HHHHHHHHHHHHH--H----------------------HH---------------------HHHHH----HH FIP1L1_1 HMMSTR ----HHHHHHHHH-------HHHHHH-------E-----H-----------HHHH------------H----------------------------EEEE---------------------------E------------------------EEEEHHH------------HHHHHH----HHHHHHHHHHHHHHH-----EE---------HH-------------------EEE---------HH--------------------------------------------------------------------E----EEEE--------------EE--------------------------------------------------------------------------------H---------------------------HHHHHHHHHHH---------HHHHHH--HHHHHHHHHHHH-------------HHHHHHHHHHH-----------HHHHHHHHHHHHHHHHH------------------HHHHHH------------------------------ FIP1L1_1 porter -----HHHHHHHH--------HHHHH-----EEEE--------------HHHHH----------HHHHHH-------------------------EEEEEE----------------EEEEE----EEE----------------------EEEE-----------------------------HHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- FIP1L1_1 cdm -----HHHHHHHH--------HHHHH-----EEEE--------------HHHHH----------HHHHHH-------------------------EEEEEE----------------EEEEE----EEE----------------------EEEE-----------------------------HHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- FIP1L1_1 fdm HHHHHHHHHHHHHH----HHHHHHH-----EEEEE---HH-------------------------------------------------------------HHHH---------HHHHHHHHHHHHHHH----EEE--EEEEE--------HHEEEEEEE------------HHHH-------HHHHHHHHHHHH--------EEE---EE-----EEEEEEEEE-------HHHHHHHHH-----EEE------------------------------------EE--EEEEE------------EE--------HH-HH---HHHHHHH-----EEEEEE----------------------------------------------------------------EEHHHH------EEEE-----EEEEEEEE------HHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------ FIP1L1_1 gor ---HHHHHHHHHH--------HHHHH------HHH-HHH------------HHH------------------------------------------EEEEE-------------------------------------EEEE--------EEEEE-HHHH-----------HHHH------HHHHHHHHHHHHHHH--------------EEEEE----------------HHHH-----------EE--------------E------------------------------------------HHH-------E-----EEEEE------------EEEE----------------------------------------------------------------------------------------------------------HHHHHHHHHHHH--HHH--HHH-----HHHHHHHHHHHHH---------------HHHHHHHHHH-HHHHH---HHHHHHHHHHHHHHHHH------------------HHHHH-------------------------------- FIP1L1_1 spine --HHHHHHHHHH---------------------EE------------------------------------------------------------EEEEE-------------------EEE-----EEE----------------------EE--------------------------------------------EEEEE--------------EEE-----------EEEEE-----------------------------------------------------------------------------EEE---EEEEE-------------EEEE-------------------------------------------------------------------------------------------------------------HHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHH---------EE-----HHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHH---------------------------------------------------------- FIP1L1_1 nnssp --HHHHHHHHHHHH------HHHHHHH----EEEE------------------------------------------------------------EEEEE-----------------EEEEE----EEEE----EEEEEEE----------EEEE-HHH------------HHHHHH----HHHHHHHHHHHHHHHH--EEEEE--------------------------EEEEEEEE---------------------------------------------------------------------------------EEEEE-------------EEEEE------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------------------------------------------------- FIP1L1_1 pssfinder --HHHHHHHHHH----------HHHH----------HHH--------------------------------------------------------EEEEE-----------EE----EEEEEE----EEEEE--EE----------------EEEE-------------------------HHHHHHHHH-HHHHHH--EEEEEE----EE-----EEEE----------HHHH-------------------------------------------------HHHH----------------------------EE-EEEEEEE-HHHH-------HHHHHH--HHH-----------------------------------------------------------EE--------------------------------------HHHHHHHHHHHHHHHHHH-HHHHHHH-HHHHHHHHHHHH----------------HHHHHHHHHHHHHHH----HHHHHHHHHHHHHH----------------------------------------------------------- FIP1L1_1 sspal ----HHHHHHHHH------HHHHHHHHH----EEEEHHHHHHHH---------------------------------------------------EEEEE-----------------EEEEEEE--EEEE---------------------EEEEEEE-----------------------HHHHHHHHH--------EEEEEEE---------EEEEEEE------------------------------------------------------------------------------------HHHHH-----EEEEEEEEEHHHHHHHHHH---EEEE--------------------------------------EEEE-------------------------------------------------------------------HHHHHHHHH---------------HHHHHHHHHHHH---------EEEE--HHHHHHHHHHH-------HHHHHHHHHHHHHHHH----------------------------------------------------------- FIP1L1_1 ssp -----HHHHHH--------------EE---------------------------------------------------------------------EEEE-----------------------------------------------------EE--------------------------HHHHHHHHH-------------HHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- FIP1L1_1 sspred --HHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHH-----H-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHH-------HH-----HH-------HHHHHHHH----HHHH-----------------------H-------HH-----------HH-------- FIP1L1_1 netsurfp -----H--HHHHH---------HHHH---------------------------------------------------------------------EEEEEE-------------------------------------------------EEEE-----H--------------HH-----HHHHHHHHHHHHHHHHH-----HHHHHH---------------------------------HHHH---------------------------------------------------------------------------------------------E-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H---------------------------HHH---------------------------------HHH--H----- FIP1L1_1 soprano --HHHHHHHHHHH---------HHHH----------------------------------------------------------------------EEEE----------------------------------------------------EE---------------------------HHHHHHHHHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH----------HHHHHHHHHHHHHH-H-------------------------------------------------------- FIP1L1_1 consensus MASGSGDSVTRRSVASQFFTQEEGPGIDGMTTSERVVDLLNQAALITNDSKITVLKQVQELIINKDPTLLDNFLDEIIAFQADKSIEVRKFVIGFIEEACKRDIELLLKLIANLNMLLRDENVNVVKKAILTMTQLYKVALQWMVKSRVISELQEACWDMVSAMAGDIILLLDSDNDGIRTHAIKFVEGLIVTLSPRMADSEIPRRQEHDISLDRIPRDHPYIQYNVLWEEGKAALEQLLKFMVHPAISSINLTTALGSLANIARQRPMFMSEVIQAYETLHANLPPTLAKSQVSSVRKNLKLHLLSVLKHPASLEFQAQITTLLVDLGTPQAEIARNMPSSKDTRKRPRDDSDSTLKKMKLEPNLGEDDEDKDLEPGPSGTSKASAQISGQSDTDITAEFLQPLLTPDNVANLVLISMVYLPEAMPASFQAIYTPVESAGTEAQIKHLARLMATQMTAAGLGPGVEQTKQCKEEPKEEKVVKTESVLIKRRLSAQGQAISVVGSLSSMSPLEEEAPQAKRRPEPIIPVTQPRLAGAGGRKKIFRLSDVLKPLTDAQVEAMKLGAVKRILRAEKAVACSGAAQVRIKILASLVTQFNSGLKAEVLSFILEDVRARLDLAFAWLYQEYNAYLAAGASGSLDKYEDCLIRLLSGLQEKPDQKDGIFTKVVLEAPLITESALEVVRKYCEDESRTYLGMSTLRDLIFKRPSRQFQYLHVLLDLSSHEKDKVRSQALLFIKRMYEKEQLREYVEKFALNYLQLLVHPNPPSVLFGADKDTEVAAPWTEETVKQCLYLYLALLPQNHKLIHELAAVYTEAIADIKRTVLRVIEQPIRGMGMNSPELLLLVENCPKGAETLVTRCLHSLTDKVPPSPELVKRVRDLYHKRLPDVRFLIPVLNGLEKKEVIQALPKLIKLNPIVVKEVFNRLLGTQHGEGNSALSPLNPGELLIALHNIDSVKCDMKSIIKATNLCFAERNVYTSEVLAVVMQQLMEQSPLPMLLMRTVIQSLTMYPRLGGFVMNILSRLI MKQVWKYPKVWEGFIKCCQRTKPQSFQVILQLPPQQLGAVFDKCPELREPLLAHVRSFTPHQQAHIPNSIMTILEASGKQEPEAKEAPAGPLEEDDLEPLTLAPAPAPRPPQDLIGLRLAQEKALKRQLEEEQKLKPGGVGAPSSSSPSPSPSARPGPPPSEEAMDFREEGPECETPGIFISMDDDSGLTEAALLDSSLEGPLPKETAAGGLTLKEERSPQTLAPVGEDAMKTPSPAAEDAREPEAKGNS Symplekin_1 sequence -------------------------------HHHHHHHHHHHHH----HHHHHHHHHHHHHHH------HHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHEE-------------------------------HHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHH-----HHHHHHHHHHH--------HHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHH----HHHHHH------------------HHHH-------------------------------------HH---------HHHHHHHHHHHH--------HHHHH----------HHHHHHHHHHHHH----------------------HHHHHHHHHHHHHHHH-------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------HHHHHHHHHHHH---------HHHHHHHH-----HHHHHHHHHH-----HHHHHHHHHHHHHH-----HHHHHHHHHH-----HHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHH-----------------------HHHHHHHHHHHHHH------HHHHHHHHHHH--HHHHHHHHHHHHHHHHH-----HHHHHHHHH-----HHHHHHHHHHH-------HHHHHHHHHHHHH-----EEEEE------HHHHHHH--------HHHHHHHHHHHH---------------HHHHHHHHH--------HHHHHHHHHHHH-------HHHHHHHHHHHH- Symplekin_1 psipred --------------HHHH-HHH---------HHHHHHHHHHHHH----HHHHHHHHHHHHHHH-----HHHHHHHHHHHHH----HHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHEEE------------------------------HHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHH--HHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHH--HHHHHHHH---HHHHH------HHHHHH---------------------------------------HHHHHH---HHHHHHHHHHHHHH--HHHHHHHHHHH-HHH-------HHHHHH--------------------------------HHHHHHH--------------------------------------------HHHH-HHHHHHHHHHH----HHHHHHHHHHHHHHHHHH-HHHH----HHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHH-----HHHHHHHHHH-----HHHHHHHHHHH-----HHHHHHHHHHHHH-----HHHHHHHHHHHH----HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHH----------------------HHHHHHHHHHHHHHH---HHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHH-----HHHHHHHHH----HHHHHHHHHHHHH------HHHHHHHHHHHHH-----EEEEHHHH---HHHHHHHHHHHH---HHHHHHHHHHHH---------------HHHHHHHHHH-------HHHHHHHHHHHH-------HHHHHHHHHHH-- Symplekin_1 prof -----------------------------HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHH-------HHHHHHHHH-----HHHHHHHHHHHHHHHH--HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHEE-------------------------------HHHHHHHHHHHHHHHHHHH--------EEEEEHHHHHHHHHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHH---HHHHHHHHHHHHHHHH-------------------------------------------------------------HHHHHHHHHHH--------HHHH-------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHH-------------HHHHHHHHH----HHHHHHHHHHHHHH----HHHHHHHHHHHHHHH---------HHHHHHHHHHHHHHH-------HHHHHHHHH-----HHHHHHHHHH------HHHHHHHHHHHHH-----HHHHHHHHHHH-----HHHHHHHHHHHHHH------HHHHHHHHHHHHHHHH----------------------HHHHHHHHHHHHHH-----HHHHHHHHHH----HHHHHHHHHH---HHHHH----HHHHHHH-------HHHHHHHHHHHH------HHHHHHHHHHHH-----EEEEEE------HHHHHHHHHHHH----HHHHHHHHHEE---------------HHHHHHHHH--------HHHHHHHHHHH---------HHHHHHHHHH-- Symplekin_1 jnet -------------------------------HHHHHHHHHHHHH----HHHHHHHHHHHHHHH----HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHEEE------------------------------HHHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHH---HHHHHHH------HH----------HHH-------------------------------------HHHH-------HHHHHHHHHHHHHH-----HHHHHHH----------HHHHHHHHHHHHH-----------------------------------------------------------------------------------------HHH------HHHHHHHHHHHHHHHHHH-HHHH---HHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHH------HHHHHHHHH-----HHHHHHHHHH-----HHHHHHHHHHHHHH-----HHHHHHHHHHHHH---HHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHH--------------------HHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHH----HHHHHHHHHHHHH------HHHHHHHHHHHHH-----EEEEE------HHHHHHHHHHHH---HHHHHHHHHHHH---------------HHHHHEHE---------HHHHHHHHHHHHH------HHHHHHHHHHHH- Symplekin_1 sable ---------------HHH-----------HHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHH---HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHH------------------------------HHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------HHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHH--HHHHHHHHH---------------HHHHHH-------------------------HHH----HHHHHHHHHHH---HHHHHHHHHHHHHH---HHHHHHHHHHHHH------HHHHHHHHH-------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHH-HHHH----HHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHH----HHHHHHHHHHH-----HHHHHHHHHHH---HHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHH-----------------HHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHH---HHHHHHHHHHHHHHHH------HHHHHHHHH----HHHHHHHHHHHHH------HHHHHHHHHHHHH----EEEEEE------HHHHHHHHHHH----HHHHHHHHHHH----------------HHHHHHHHH--------HHHHHHHHHHHHH------HHHHHHHHHHH-- Symplekin_1 proteus ------HHHEHEEHHHHHHHHH-------H-HHHHHHHH--HH-------HHHHHHHHHHHHH-----HHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHH-HHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHH-------HEEEEEHHHHEEEEEE------------------H-----------HHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHH-HHHHHHHHHHHHH--------HHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHH----HHHHHHH----------------HHHHHHH----------------------HHHHHH---------HH--H-----HHHHHHHHHHH----HH--HHHHHH---HH---HHHHHHHHHHHHHHH--H--------H-----------------EEEEE--------EE----------------------------------------EEEEE---------HHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHH---HHHHHHHHHHH------HHHHHHHHHHH---HHHHHHHHHHHHHHHH---HHHHHHHHHHHH-----HHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHH----HHHHH-------------HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHH-----HHHHHHHHHHHHH------HHHHHHHHHHHH-----HEEEEEHH----HHHHHHH--HH----HHHHHHHHHHHHH--------------HHHHHHHHH--------HHHHHHHHHHHHHHH--HHHHHHHHHHHHHH- Symplekin_1 sspro4 --------------HHH--------------HHHHHHHHHHHHHH---HHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHH------------------HHH---------HHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHH---HHHHHHHHH-HHHHH--------HHHHHH-------------------------HHHH-----HHHHHHHHHHH--HHHHHHHHHHHHHH---HH-HHHHHHH---------HHHHHHHHH--------------------------------------------------------------------------------HHHHH---HHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHHH---HHHHHHHHHHH-----HHHHHHHHHHH---HHHHHHHHHHHHHHHH---HHHHHHHHHHHHHH---HHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHH----HHH------------HHHHHHHHHHHHHHHHH---HHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHH----HHHHHHHHH----HHHHHHHHHHHHH------HHHHHHHHHHHHH----EEEEEEE-----HHHHHHHHHHHHH--HHHHHHHHHHHHH--------------HHHHHHHHHH-------HHHHHHHHHHHHH------HHHHHHHHHHHH- Symplekin_1 psspred --------------HHH--------------HHHHHHHHHHHHHH---HHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHH-------------------------------HHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------HHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHH---HHHHHHH-----------------HHHHHHH----------------------HHHH----------HHH------HHHHHHHHHHHHHH-----HHHHHHH----H----HHHHHHHHHHHHHHHHHH------HHHHH----HHHHHHHHHHHHHHHHHHHH------------------HHHHHH------------HHHHH-----HHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHH-----HHHHHHHHHH-----HHHHHHHHHHH--HHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHH------HH--------------HHHHHHHHHHHHHH----HHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHH----HHHHHHHHH----HHHHHHHHHHHHH------HHHHHHHHHHHHH----EEEEEE------HHHHHHHHHHHHH--HHHHHHHHHHHHH--------------HHHHHHHHHH-------HHHHHHHHHHHHH------HHHHHHHHHHHH- Symplekin_1 spineX --------------------------------HHHHHHHHHHHH----HHHHHHHHHHHHHHH---HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHE------HHHHHHHHHHHHHH-HEEE---------EHHHHHH--EEEEEE------------------------------HHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHH--HHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHH----HHHHHH-------------------------------------------------EEE------------------HHHHHHHHHHHHH-----------EEE----------------------------------------------------------------------------------------------------------EEEEE---------HHHHHHHHH-HHH-EEEEEEEEEE----EEEEEEEEEEEEE--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHH-----HHHHHHHHHHH------HHHHHHHHHHH--HHHHHHHHHHHHHHHH-----HHHHHHHHHHH-----HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHH----------------------HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHH-----HHHHHHHHHHH-------HHHHHHHHHHHH------EEEEE------HHHHHH---HH----HHHHHHHHHHHH---------------HHHHHHHHH--------HHHHHHHHHHHH-------HHHHHHHHHHHH- Symplekin_1 raptorxss ----------------HEE------------HHHHHHHHHHHHH----HHHHHHHHHHHHHHHH--HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHE------------------HHH---------HHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHH-HHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHH---HHHHHHHHH--HHHHHH-------HHHHHH------------------------HHH----------HHH-H----HHHHHHHHHHHHH---HH-HHHHHHHH------------------------------------------HHHH----------------------------------H----------------HHHHH--------E---------HHHHHHHHHHHHHHHHHH-HHHH----HHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHH----HHHHHHHHHHH------HHHHHHHHHH---HHHHHHHHHHHHHHHHH-----HHHHHHHHHHHH---HHHHHHHHHHHHHH-------HHHHHHHHHHHHHHH-----HHH--------HHHHHHHHHHHHHHHHHH------HHHHHHHHHHHH---HHHHHHHHHHHHHHHHH-----HHHHHHHHH----HHHHHHHHHHHH-------HHHHHHHHHHHH------EEEEEE-----HHHHHHH-HHH----HHHHHHHHHHHH---------------HHHHHHHHHH-------HHHHHHHHHHHH-------HHHHHHHHHHH-- Symplekin_1 SPARROW -------------HHHHH-------------HHHHHHHHHHHH----HHHHHHHHHHHHHHHHH---HHHHHHHHHHHHH-----HHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHEEEEE------------------HHH---------HHHHHHHHHHHHHHHHHHH--------HHHHHHHHHHHHHH--HHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHH-HHHHHHHH-H-HHHHH--------HHHHH-------------------------------------HHHH------HHHHHHHHHHHHH----H-HHHHHHH-------------------------------------------------------------------------------------------------------------HH----------HHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHH--HHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHH-----HHHHHHHHHHH-----HHHHHHHHHH---HHHHHHHHHHHHHHHH-----HHHHHHHHHHHHH---HHHHHHHHHHHHHH------HHHHHHHHHHHHHHHH-----HHH------------HHHHHHHHHHHHHHHH----HHHHHHHHHHH----HHHHHHHHHHHHHHHHH-----HHHHHHHHH-----HHHHHHHHHHHH------HHHHHHHHHHHHH----HHHHEHHH----HHHHHHH-HHH----HHHHHHHHHHHH---------------HHHHHHHHHH-------HHHHHHHHHHHH-------HHHHHHHHHHH-- Symplekin_1 *SPARROW --------EEHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHEEEEE------------------EE-------EE-HHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------HHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHH-------------------HHHHHHHHHHHHHHHHHHHHEE----HHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHH------------------------HHHHHHHHHHHHH---HHHHHHHHHHHHH----------------------HHHHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHH--HH-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHH-HHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHH---HHHHHHHHHH-----HHHHHHHHHHHHH----HHHHHHHHHHHHHHH----EEE-----H--HHHHHHHHHHHHE--HHHHHHHHHHHHH--------------HHHHHHHHHHH-HHH--HHHHHHHHHHHHHH-----HHHHHHHHHHHHH Symplekin_1 HMMSTR ------------HHHHHHHH----------HHHHHHHHHHHHH-----HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHH-------------------HHH---------HHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHH-----HHHHH---------------------HH------------------------------------HHHHH-------HHHHHHHHH------HH-HHHHHHHH-HHHH----HHHHHHHHHHHHHHHH--------------------------EEEE---------EEEE--------------------------------------EEEEE---------HHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHH-------HHHHHHHHH------HHHHHHHHHHH-----HHHHHHHHHHHHH-----HHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------HEE-------------HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHH--HHH------HHHHHHHH-----HHHHHHHHHHHHH------HHHHHHHHHHHH-----HHHHHHH-----HHHHHHHHHHHH---HHHHHHHHHHHH---------------HHHHHHHHH--------HHHHHHHHHHHHHH-----HHHHHHHHHHH-- Symplekin_1 porter --------E----HHHHHE------------HHHHHHHHHHHHH-----HHHHHHHHHHHHHH---HHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHH-----------------EEE-----------HHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHH----HHHHHHH-----------------HHHHHH----------------------------------HHHHHHHHH----HHHHHHHHHHHHH-HHH-HHHHHHH--HHHH--HHHHHHHHHHHHHHHHHH------HHHHH------HHHHHHHHHHHHHH----HHHHHHHHHHHH-------HHHHHHH------------HHH-----EEEEE---------HHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHH--------HHHHHHHH-----HHHHHHHHHH------HHHHHHHHHHHHH---HHHHHHHHHHHHHH----HHHHHHHHHHHHHHH--H-HHHHHHHHHHHHHHHHH----HHHH--------------HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHH-HHHHH-----HHHHHHHH-----HHHHHHHHHHHH-------HHHHHHHHHHHHH-----EEEEE------HHHHHHH-HHHH---HHHHHHHHHHHHH--------------HHHHHHHHH--------HHHHHHHHHH-H------HHHHHHHHHHHH-- Symplekin_1 spine ---------HHHHHHHHHHHHH----------HHHHHHHHHHHHH-------HHHHHHHHHHH----HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---EEEEE------HHHHHHHHH--EEEEE----------------------------EEEEHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHH----HHHHHHH----------------HHHHHHH----------------------HHHHHH-------HHHHHHHHH-----HHHHHHHHHH-------HHHHHHH--------HHHHHHHHHHHHHHHHHH-----HHHHHHHHH--HHHHHHHHHHHHHHHHHHH----EEEE-------HHHHHHHHHH-----EEE------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHH-------EEEEEE----HHHHHHHHHHHHHHHH--------HHHHHHHHH----HHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------EEEE-------------HHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHH-----HHHHHHHHHHHH-------HHHHHHHHHHHHHH----EEEEE------HHHHHHHHHHHHH---HHHHHHHHHHH-----------------HHHHHHH--------HHHHHHHHHHHHHH-----HHHHHHHHHHHHH Symplekin_1 nnssp -------EEEEEEEEEEEEE-----------HHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----EEEEEE-----EEEEEEEEE--EEEEE------------------------------HHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHH----HHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHH----HHHHHHH---------------HHHHHHHH-------------------------------------HHHHHHH--HHHHHHHHHHHHHH---------------------HHHHHHHHHHHHHHHHHH-----------------HHHHHHHHHHHHHHHHHH---EEEEE-------HHHHHHHHHHH---------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHH-----------EEEEEEE-----HHHHHHHHHH----------HHHHHHHHHH-HHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------EEEEEE-----------HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHH------------HHHHHHHHH------EEEEEEEE---------HHHHHHHHHHHHHH---EEEEEE------HHHHHHHHHHHHH--HHHHHHHHHHHH------------------EEEEEE--------HHHHHHHHHHHHHHH----HHHHHHHHHHH-- Symplekin_1 pssfinder HH------HHHHHHHHHHHHH-----------HHHHHHHHHHHHH-----HHHHHHHHHHHHH---HHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----EEEE-----HHHHHHHHHHHHHHHH----HHHHH-HHHHH----------------HHHHHHHHHHHHHHHHHHH---------HHHHHHHHHHHH---HHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHH-----HHHHHH---------------HHHHHHHHH--------------------------------HHHHHHHHH---------HHHHHHHHHH-----HHHHHHH--------HHHHHHHHHHHHHHHHHH-----HHHHHHH----HHHHHHHHHHHHHHHHHHH----EEEE-----HHHHHHHHHH-------EEE----HHHH----HHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHH------------HHHHHH-----HHHHHHHHHHHH------EE--HHHHHHHH----HHHHHHHHHHH------HHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHH-------EEEE----HHHHHH-HHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------HHHHHHH----HHHHHHHHHHHHH-------HHHHHHHHHHHH-------EEEEE-----HHHHHHHHHHHH---HHHHHHHHHHHH---------------HHHHHHHHH--------HHHHHHHHHHHHHH-----HHHHHHHHHHHHH Symplekin_1 sspal -------EEEE--EEEEEEE---------HHHHHHHHHHHHHH----------HHHHHHHHH---HHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHH--EEEEEEE----HHHHHHHHHHHHEEEE----------HHHHHHHHHHH---------HHHHHHHHHHHHHHHHHEEEE-------HHHHHHHHHHHHHH--HHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHH----HHHHHHEEEEEEE---HHHHHHHHH---------------HHHHHHHHH----HHHHHHHHH----------------------HHHHH----------EEEEEEEE--HHHHHHHHHH------HHHHHHHHHHHHHHH--------------------------EEEE--EEEE-------EEEEEEE-------HHHHH---------EEEEE---------HHHHHHHHHHHH---HHHHHHHHH-HHHHHHHHH---HHHHHHHEEEEEEE-----------HHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHH-----------EEEEEEE------HHHHHHHHHHHH----EEEEHHHHHHHHHHH----EEEEEEEEEEE--HHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHH------EEEE-----------HHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHH-HHHHHHHHHHH---------HHHHHHHHH----HHHHHHHHHH----------HHHHHHHHHH------EEEEEHHHHHHHH-HHHHHHHHHHH-----HHHHHHHHH----------------HHHHHHHHH---EEEEEEEEEE-----------HHHHHHHHHHHHHH- Symplekin_1 ssp ---------HHH-HHHHHHHHHH--------HHHHHHHHHHHHHH----HHHHHHHHHHHHHH-------HHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE-----HHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHEEE------------------------------HHHHHHHHHHHHHHHHHHH---------HHHHHHHHHHHHH--HHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHH--HHHHHHHH--HH---------------------------------------------------HHHHHHH---------HHHHHHH-HHH--HHHHHHHHHHHHHHH-----HHHHHHHHHHHHHH-----------HH-----------------HH------------------------------------------HHHHHHHHHHH------------HHHHHHHH-HHHH-HHHHHHHHH----HHHHHHHHHH-HH----HHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHH--------HHHHHHHHHHHHHH--------HHHHHHHH-----HHHHHHHHHHH----HHHHHHHHHHHHH-------HHHHHHHHHHH------HHHHHHHHHHHHH----HHHHHHHHHHHHHHHHH----HHHHH--------------HHHHHHHHHHH-------HHHHHHHHHHH--HHHHHHHHHHHHHHHHHHH----HHHHHHH------HHHHHHHHHH---------HHHHHHHHHHHH-----HEEEEE------HHHHHHH---------HHHHHHHHHHH---------------HHHHHHHHH---------HHHHHHHHHHHHHH---HHHHHHHHHHHH-- Symplekin_1 sspred --------------HHHHHHHHH--------HHHHHHHHHHHH-----HHHHHHHHHHHHHHH-----HHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHH-------------------EE----------HHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHH-HHHHHHHHHHHHHH---------HHHHHHHHHHHHHHHHHHH--------HHHHHHHHHHHHHHHHHHHHHH---HHHH--------HHHHHH-------------------------HH---------HH---------HHHHHHHHHHHHH----HHHHHHHHH------------HHHH--------------------------------------HH------------------------HHHH--------------HHHHHHH-HHHH-----------HHHHHHHHHHHHHHHHHH---------HHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHH-----HHHHHHHHHH-----HHHHHHHHHH-----HHHHHHHHHHHHHH-----HHHHHHHHHHHHH---HHHHHHHHHHHHHH------HHHHHHHHHHHHHHHH-------------------HHHHHHHHHHHHHHHHH-----HHHHHHHHHHH---HHHHHHHHHHHHHHHHH-----HHHHHHHH-----HHHHHHHHHHHHH------HHHHHHHHHHHHH-----EEEEHH-----HHHHHHH--------HHHHHHHHHHHH---------------HHHHHHHHH--------HHHHHHHHHHHH-------HHHHHHHHHHH-- Symplekin_1 netsurfp ---------------------HH---------HHHHHHHHHHHH----HHHHHHHHHHHHHHHH--HHHHHHHHH-H-HHH----HHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHH-----H-HHHHHHHHHHHHHHHHHHH-----HHHHHEEEEEEEEEEHH------------------E---------E-HHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHH-HHHHHHHHHHHHHHH---------HHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHH---HHHHHHHHHHHHH-------------HHHHH---------------------HHHH-----------HHH-------HHHHHHHHHHHH-----H-HHHHH------------------HHHH-----------------------------------HHH-----------------------------------------HHHH-----H-----------HHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHH---------HHHHHHHHHHHHHH---H-HHHHEEEHHHH----HHHHHHHHHHH--HHHHHHHHHHHHHHHHH----HHHHHHHHHHHHH---HHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHH----HHHH-------------HHHHHHHHHHHHHHHH--HHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHH----HHHHHHHHH-----HHHHHHHHHHHHHH----HHHHHHHHHHHHH-----EEEEEEE----HHHHHHHHHHHHH--HHHHHHHHHHHHH--------------HHHHHEHHHH-------HHHHHHHHHHHHHH-----HHHHHHHHHHHH- Symplekin_1 soprano --------------HHHH-------------HHHHHHHHHHHHH----HHHHHHHHHHHHHHH---HHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHEEE------------------------------HHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHH-HHHHHHHHHHHHHH--------HHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHH---HHHHHHHH----------------HHHHHH-----------------------------------HHHHH------HHHHHHHHHHHHH----H-HHHHHHH----------HHHHHHHHHHHH--------------------------------HH---------------------------------------------H-----HHHHH---------HHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHH------HHHHHHHHHH-----HHHHHHHHHHH----HHHHHHHHHHHHHH-----HHHHHHHHHHHH----HHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHH------HH--------------HHHHHHHHHHHHHH----HHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHH-----HHHHHHHHH----HHHHHHHHHHHHH------HHHHHHHHHHHHH-----EEEEE------HHHHHHHHHHHH---HHHHHHHHHHHH---------------HHHHHHHHH--------HHHHHHHHHHHHH------HHHHHHHHHHHH- Symplekin_1 consensus MSEGVDLIDIYADEEFNQDPEFNNTDQIDLYDDVLTATSQPSDDRSSSTEPPPPVRQEPSPKPNNKTPAILYTYSGLRNRRAAVYVGSFSWWTTDQQLIQVIRSIGVYDVVELKFAENRANGQSKGYAEVVVASENSVHKLLELLPGKVLNGEKVDVRPATRQNLSQFEAQARKRECVRVPRGGIPPRAHSRDSSDSADGRATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPPPPIPPPPPLSSSFGVPPPPPGIHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFPPPNATVGPPPDTYMKASAPYNHHGSRDSGPPPSTVSEAEFEDIMKRNRAISSSAISKAVSGASAGDYSDAIETLLTAIAVIKQSRVANDERCRVLISSLKDCLHGIEAKSYSVGASGSSSRKRHRSRERSPSRSRESSRRHRDLLHNEDRHDDYFQERNREHERHRDRERDRHH CPSF7_1 sequence ---------------------------------------------------------------------------------EEEEEE-------HHHHHHHHHH------EEEEEEE---------EEEEEE--HHHHHHHHHH-----------EEE-------HHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHH------HHHHHHHHHH--------HHHHHHHHHHHHHHH-----HHHHHHHHHHHHHH---------------------------------HHHH-------------HHHHHHHHHHHHHHHHHHH--- CPSF7_1 psipred ---------------------------------------------------------------------------------EEEEEE-------HHHHHHHHHH-----EEEEEEEEE--------EEEEEE--HHHHHHHHHH----------EEEEE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHH--------HHHHHHHHHH-----HHHHHHHHHHHHHHHH------HHHHHHHHHHHHHH-----------------------------------------------------HHH-HHH----------- CPSF7_1 prof ---------------------------------------------------------------------------------EEEEE-------HHHHHHHHHHHH------EEEEEE--------EEEEEEE--HHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEE-HHHHHHHH-----------HHHHHHHHH-------------E---------EEEEE------------------------------------------------------------------ CPSF7_1 jnet ---------------------------------------------------------------------------------EEEEE--------HHHHHHHHHH------EEEEEEE---------EEEEEE--HHHHHHHHHH----------EEE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH--------HH-HHH----------HHHHHHHHHHHHHH----------------HHH---------------------------------------------------------HH-------------- CPSF7_1 sable ---------------------------------------------------------------------------------EEEEEE-------HHHHHHHHHH-----EEEEEEEEE--------EEEEEE--HHHHHHHHHH----------EEEEE---HHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHH-----------------------------------HHHHHHHH-----------HHHHHHH---------- CPSF7_1 proteus ------HHHH---HHHH------------HHHH------------------------------------EEEEEE-----EEEEEEE---E---HHHHHHHHHH-----EEEEEEEE---------EEEEEE--HHHHHHHHHH-----------------HHHHHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHH----H--HHHHHHH----------HHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHH---H-------------------------------HHHHHHH-------HHHHHH---HHH---------- CPSF7_1 sspro4 ----------------------------------------------------------------------------------EEEE--------HHHHHHHHHHH----EEEEEEEE--------EEEEEEE--HHHHHHHHHH-----------EEEE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHH--HHHHHHHHH------HHHHHHHHHHHH-- CPSF7_1 psspred ---------------------------HHHHHHHH---------------------------------------------EEEEEE--------HHHHHHHHHHH------EEEEEEE--------EEEEEE--HHHHHHHHHH-----------EEE--------HHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHH------HHHHHHHHH---------HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHH-----------HHHH-HH-------HHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHH-- CPSF7_1 spineX ---------EE-----------------------------------------------------------------------EEEE--------HHHHHHHHH-------EEEEEEEE--------EEEEEE----HHHHHHH-----EE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H---------------HHHH---HHH----------HHHHHHH------------------------HHH-----------------HHHHH----------------------------- CPSF7_1 raptorxss ---------------HHH--------------------------------------------------------------EEEEEEEEE-----HHHHHHHHHH------EEEEEEE---------EEEEEE--HHHHHHHHHH-----------EEEE----HHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E---HH----------------HH---HH-E------------------HHHHHHHHHH--------------------------HHHH---------HHHHHH--------HHHHHHHHHH--- CPSF7_1 SPARROW ---------------------------------------------------------------------------------EEEEEE-------HHHHHHHHHHH----EEEEEEEEE--------EEEEEE--HHHHHHHHHH-----------EE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- CPSF7_1 *SPARROW ------EEEEEE--------HH-HHHHHHHHHHHH---------------------------------------------EEEEEEE-EEEEE-HHHHHHHHHHH-----EEEEEEE------EE-EEEEEEEEHHHHHHHHHHH----E---EEEEEEE--H-HHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHH--EEEHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHH----------------H-----H-----HHHHH-HH---H---HHHHHHHHHHHHHHHHHHHHHHHHHHH CPSF7_1 HMMSTR ------EEEE---------HH---------HH------------------------------------EEEEEE------EEEEEE--E-----HHHHHHHHHH-----EEEEEEE---------EEEEEEE--HHHHHHHHHH------------EE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH---------------------HHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHH---------------------------------HHHHHHHHHH------HHHHHHHH--------------- CPSF7_1 porter -----EEEEE--HHHHHHHHHHH---------EEEEE-----HHHHHHHHHHH----------------------------EEEEEE-------HHHHHHHH-------EEEEEEEE---------EEEEEE---HHHHHHHHHH---------EEEEEE-----HHHHHHHHH----EEEE--------HHHHHHH---------EEEE---------------------HHHHH-------------------------------------------------------------------------------------------------------------------------------HHHHH---------------------------HHHHH--------------------------------------------------------HHHH----------- CPSF7_1 cdm -----EEEEE--HHHHHHHHHHH---------EEEEE-----HHHHHHHHHHH-------------------------------EEE-------HHHHHHHHH--------EEEEEE------EEEEEEEE-------HHHHHH----EE--EE-EEE---HHHHHHHHHHH------------------HHHHHHH---------EEEE---------------------HHHHH-------------------------------------------------------------------------------------------------------------------------------HHHHH---------------------------HHHHH--------------------------------------------------------HHHH----------- CPSF7_1 fdm -------EEE--------------------------------------------------------------------------EEE-------HHHHHHHHH--------EEEEEE------EEEEEEEE-------HHHHHH----EE--EE-EEE---HHHHHHHHHHH----------------HHHHHHHHHHHHHHHH----EEEEE------------------------------------------------------------------------------------------------------------------------------HHH--------------------------------------------------------------------------------------------------------------------------------- CPSF7_1 gor -----HHHH---------------------HH-HE----------------------------------EEE---------EEEEEE-------HHHHHHHHHH---E-EEEEEEEEE-------EEEEEEE--HHHHHHHHHH----------EEEE--------HHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHH---------------------HHHHHHHHHHHHHHHHHHH--------EEH--HHHHHHHHHHH----------HHHH-----------HHHHHHHH----------HHHHHHHHHHHHHHHHHHH--- CPSF7_1 spine ------HHHHH---------------------------------------------------------EEEEE--------EEEEE---------HHHHHHHHH-----EEEEEE------------EEEEEE----HHHHHHH--------------------HHHHHHH-----EEE----------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHH-------HHHHH---------HHHHHHHHHHHHHHH---------EEEEE--------------------------------------------------------HHHHHH-HHHHHH--------- CPSF7_1 nnssp ------EEEEE---------------------------------------------------------EEEEE-------EEEEEE---------HHHHHHHHHH----HHHHHHHHHHH------EEEEEEE-HHHHHHHHHH-----------------HHHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHH-----HHHHHHHH-------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------------------------HHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHH-- CPSF7_1 pssfinder ------EEEEEE--------------HHHHHHHHHH---------------------------------EEEE----------EEE--EEEE----HHHHEEEE-EEEEEEEEEEEE---------EEEEEEE----HHHHHHH--------------------HHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHH--HHHHHHHH----------HHHHHHHHHHHHHHH---------HHHHHH----------------------------------------HHHHHHH-------HHHHHHHHHHHHH--------- CPSF7_1 sspal --------------------------HHHHHHHHHHH-------------------------------EEEEEEE--------EEEEEEE------EEEEEEE--EEEEEEHHHHHHHHH------HHHHHHHHHHHHHHHHHH---EEEE-----HHHHHHHHHHHHHHHHH---EEEE-------------------------------------------------------------------EEEEEEEE-----EEEEEEE--------EEEE---------------------EEEE-------------------------EEEEHHHHHHHHH------------------HHHHHHHHHHHHHHH-------------EEEEEHHHHH---------EEEE-----------------------HHHHHHHHH---HHHHHHHHH---------------- CPSF7_1 ssp -------EEEE------------------------------------------------------------------------EEEE-------HHHHHHHHHHH-------EEEE-----------EEEEE--HHHHHHHHHH----------EEEE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHH-----------HHHHHHHH---------------H-------------------------------------------------------------------------------- CPSF7_1 sspred ----------------------------------------------------------------------------------EEEEE-------HHHHHHHHHH------EEEEEEE--------EEEEEEE--HHHHHHHHHH---------EEEEEE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHH------------------------------------------------------------------------------- CPSF7_1 netsurfp -----------------------------EE--------------------------------------------------EEEEEE-------HHHHHHHHHHH-----EEEEEEE--------EEEEEEE--HHHHHHHHHH-----------EEE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-HH-HH---------------HH-HHHHH----E------HHHH------H--HHHH------------------------------------------------HHH-------HHH---- CPSF7_1 soprano ---------------------------------------------------------------------------------EEEEEE-------HHHHHHHHHH------EEEEEEE---------EEEEEE--HHHHHHHHHH-----------EEE-------HHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHH---------HH-HH----------HHHHHHHHHHHHH------------HH---HHHH--------------------------------------------------H----H-HHHH----------- CPSF7_1 consensus MSAGEVERLVSELSGGTGGDEEEEWLYGDENEVERPEEENASANPPSGIEDETAENGVPKPKVTETEDDSDSDSDDDEDDVHVTIGDIKTGAPQYGSYGTAPVNLNIKTGGRVYGTTGTKVKGVDLDAPGSINGVPLLEVDLDSFEDKPWRKPGADLSDYFNYGFNEDTWKAYCEKQKRIRMGLEVIPVTSTTNKITVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRRLPGAIDVIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFLPPPPTVSTAPPLIPPPGFPPPPGAPPPSLIPTIESGHSSGYDSRSARAFPYGNVAFPHLPGSAPSWPSLVDTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQESTEATPAE FIP1L1_3 sequence --HHHHHHHHHH---------------------------------------------------------------------EEEE---------------------------------------------------------------------------------HHHHHHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHH------------------HHHHHHHHHHH---------------HHHHHHHHHH----HHH---HHHHHHHHHHH--HHHHH------------------------------------------------------- FIP1L1_3 psipred ---HHH---------------------------------------------------------------------------EEEE---------------------------------------------------EEEEE-------------------------HHHHHHHHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- FIP1L1_3 prof ------EEEEE-----------------------------------------------------------------------EE---------------------------------------EE----------EEEEE-----------------------------HHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- FIP1L1_3 jnet -------HHH-----------HHHH--------------------------------------------------------EEEEE--------------------------------------------------EEE---HHH-------------EEE-----HHHHHHHHHHHHHHHH-------HHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- FIP1L1_3 sable --------------------------------------------------------------------------------EEEEE----------------------------------------------------------------------------E----HHHHHHHHHHHHHHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHH--------------------HHHHHHH------HHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHH----------------------------------- FIP1L1_3 proteus ------EEEEEE-------HHHHHHH------------------------HHHHH-----------EE------------EEEEEEE-----------------------------------------------EEEEEE-HHH------------HHHHHH----HHHHHHHHHHHHHHHHH-----------EEEEE----------E----------------------------H-----EEEEEEEE------------EEE-----------------------------------------------------------------E-----------------------------------------------HHHHHHHHHHHHHHHHH-----HHHHHHHHHHHH-------------HHHHHHHHHHH---HH----HHHHHHHHHHHHHHHH--------------------------------------------------------- FIP1L1_3 sspro4 --HHHHHHHH-----------HHHH--------------------------------------------------------EEEE---------------------------------------------------EEEE----------------HHHHH------HHHHHHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHH--- FIP1L1_3 psspred --H-HHHHHHHHH-------HHHHHHH-----HH-HHHHHH---------------------------------------EEEE---------------------------------------------------EEEEE-HHH------------HHHHH-H---HHHHHHHHHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--H------HHHHH------ FIP1L1_3 spineX ----------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHH-HHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHH--------------------- FIP1L1_3 raptorxss ----HHHHHHHH---------HHH---------------------------------------------------------EEEE----------------------------------------------E---EEEEE-H----------------EEE-----HHHHHHHHHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHH------------H----HH--H-----------------------------------------HH------------H---H------ FIP1L1_3 SPARROW ----------------------HH-------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHH----------------------H-------------------HHHH---------------------- FIP1L1_3 *SPARROW --HHHHHHHHHHHHHHHHH-HHHHHEE----------------------HHH-----------------------------EEEEE---------------------------------------------E---EEEE--HHH-------------HHH------HHHHHHHHHHHHHHHHHH------HH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHH---HHH--------------------HHHHHH-----------HHHH------------------H-H-----------HH---------HH---------HHHHHHH---HH FIP1L1_3 HMMSTR ----HHHHHHHHH-----------HHH--------HHHHHH-----------------------EE-------------EE------------HH---E------E--E-----EEEEE----EEE-----E--EEE--EE---------------------------------EE----EEE-E----------E--E-----------------------------------------------EEEE-E------------EE------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------------HHHHHHHHHHH----------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHH-------------------------- FIP1L1_3 porter -----HHHHHHHH--------HHHHHH-------HHHH-----------HHHHHHH------------------------EEEEEE--------------------------------------------------EEEE-----------------------------HHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHH-------------HHHH---HHHHH----------HHHHH-HHHHHHHHHHHHHHHHHHHH-HHHHHHHHHH-------HHHHHHHHHHHHHHHHHHHHHHHHHH------------------ FIP1L1_3 cdm -----HHHHHHHH--------HHHHHH-------HHHH-----------HHHHHHH------------------------EEEEEE--------------------------------------------------EEEE-----------------------------HHHHHHH-----------------------------------------------HH---------------------EEE----------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHH-------------HHHH---HHHHH----------HHHHH-HHHHHHHHHHHHHHHHHHHH-HHHHHHHHHH-------HHHHHHHHHHHHHHHHHHHHHHHHHH------------------ FIP1L1_3 fdm HHHHHHHHHHHHHHHHHHHHHHHHHHHH----------------------------------------------------------HHHH---------HHHHHHHHHHHHHHH----EEE------HHHHH----HH-HH---------------HHHHH-------EEE--------HHHHH-HHHHHH----EEEE------HHH-HHH---EEE-----HH---------------------EEE-HHHHHHH-----EEE-------------------------------------------------------------------EEHHHH------EEEE-----EEEEEEEE------HHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------ FIP1L1_3 gor ---HHHHHHHHHH--------HHHHH----------HHH-----------------------------------------EEEEE--------------------------------------EEEE---------EEEE-HHH------------HHHH------HHHHHHHHHHHHHHHH------HHHHHHHH-HHH--------EEE----------------------------EEEE----EEEHHH----------EEEEE----------------------------------------------------------------------------------------------------------HHHHHHHH---------------------HHHHHHHHHHH-------------HHHH-HHHHHHHHHHHHH---------HHHHHHHHHHH-------------------HHHH-------------------------------- FIP1L1_3 spine --HHHHHHHHHH------------EE------------------------------------------------------EEEEE-------------------EEE-----EEE----------------------EE--------------------------------------------EEEEE------EEEEE----------------------------------------------EEEEE-------------EEEE--------------------------------------------------------------------------------------------------------------HHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHH----------------HHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHH----------------------------------------------------------- FIP1L1_3 nnssp --HHHHHHHHHHHH------HHHHHHH-----------------------------------------------------EEEEE-----------------EEEEE----EEEE----EEEEEEE----------EEEE-HHH------------HHHHHH----HHHHHHHHHHHHHHHH--EEEEE-----EEEEEE---------------------------------------------EEEEE-------------EEEEE------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------------------------------------------------- FIP1L1_3 pssfinder --HHHHHHHHHH--------HHHHHHHH-HHHH-----------------------------------------------EEEEE-----------------EEEEEE---EEEEEE-----EEEE-----------EEEE-----------------HHH-----HHHHHHHHH-HHHHEE-EEEEEE-----EEEEE---------------------------------------EEEEEE-EEEEEHHHHHHH--------EEE---------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHH--HHH------HHHHHHHHHH----------------HHHHHHHHHHHHHHH----HHHHHHHHHHHH------------------------------------------------------------- FIP1L1_3 sspal ----HHHHHHHHH------HHHHHHHHH----------------------------------------------------EEEEE-----------------EEEEEEE--EEEE---------------------EEEEEEE-----------------------HHHHHHHHH--------EEEEEEE-----EEEE------------------------------------------EEEEEEEEEHHHHHHHHHH---EEEE--------------------------------------EEEE-------------------------------------------------------------------HHHHHHHHH---------------HHHHHHHHHHHH---------EEEE--HHHHHHHHHHH-------HHHHHHHHHHHHHHHH----------------------------------------------------------- FIP1L1_3 ssp -----HHHHHHHHH--------------------------------------------------------------------EEEE----------------------------------------------------EE---------------------------HHHHHH------HH-------HH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ FIP1L1_3 sspred ---HHHHHHH--------------------------------------------------------H----------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHH----------------------------------------------------------------HHHHHHHH---- FIP1L1_3 netsurfp ----------------------HHHH------------H-----------------------------------------EEEEE--------------------------------------------------EEEE--HHH---------------HHH-----H-HHHHHHHHHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H---------------------- FIP1L1_3 soprano ----HHHHHHHH---------HHHH-------------------------------------------------------EEEEE---------------------------------------------------EEEE--------------------------HHHHHHHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HH---HH-----------------HH-HHHHH----HH-----HHHHHHHHHH-HH----------------------------------------------------------- FIP1L1_3 consensus MGRPESAGGGSRGPFEGGGRARRAGGIFLTLSILRTRDLPSGAMSEGVDLIDIYADEEFNQDPEFNNTDQIDLYDDVLTATSQPSDDRSSSTEPPPPVRQEPSPKPNNKTPAILYTYSGLRNRRAAVYVGSFSWWTTDQQLIQVIRSIGVYDVVELKFAENRANGQSKGYAEVVVASENSVHKLLELLPGKVLNGEKVDVRPATRQNLSQFEAQARKRECVRVPRGGIPPRAHSRDSSDSADGRATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPPPPIPPPPPLSSSFGVPPPPPGIHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFPPPNATVGPPPDTYMKASAPYNHHGSRDSGPPPSTVSEAEFEDIMKRNRAISSSAISKAVSGASAGDYSDAIETLLTAIAVIKQSRVANDERCRVLISSLKDCLHGIEAKSYSVGASGSSSRKRHRSRERSPSRSRESSRRHRDLLHNEDRHDDYFQERNREHERHRDRERDRHH CPSF7_3 sequence ------------------------HHHHHHHHHHH-----------------------------------------------------------------------------------------EEEEEE-------HHHHHHHHHH------EEEEEEE---------EEEEEE--HHHHHHHHHH-----------EEE------HHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHH------HHHHHHHHHH--------HHHHHHHHHHHHHHH------HHHHHHHHHHHHH--------------------------------HHHHH-------------HHHHHHHHHHHHHHHHHHH--- CPSF7_3 psipred -------------------EEE----EEEEEEEEE----------------EE-----------------------------------------------------------------------EEEEEE-------HHHHHHHHHH-----EEEEEEEEE--------EEEEEE--HHHHHHHHHH----------EEEEE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHH--------HHHHHHHHHH-----HHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHH-----------------------------------------------------HHH-HHH----------- CPSF7_3 prof -------------------------------EEEE-----EEEE--------------------------------------------------------------------------------EEEEE-------HHHHHHHHHHHH------EEEEEE--------EEEEEEE--HHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEE-HHHHHHHH-----------HHHHHHHHHHH----------EEE-------EEEEEE------------------------------------------------------------------ CPSF7_3 jnet ------------------------HHHHHHHHHHH------------------------------------------------------------------------------------------EEEEE-------HHHHHHHHHH------EEEEEEE--------EEEEEEE--HHHHHHHHHHH---------EEEE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH------------------------HHHHHHHHHHHHHH----------------HHHH--------------------------------------------------------HHHH------------ CPSF7_3 sable --------------------HHHHHHHHHHHHHHH-----------------------------------------------------------------------------------------EEEEEE-------HHHHHHHHHH----EEEEEEEEE--------EEEEEEE--HHHHHHHHHHHHHH-----EEEEEE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH------------------------HHHH---------------------------------HHHHHHHHHH------------HHHHHH---------- CPSF7_3 proteus ---HHH-----------------HHHHHHHHHH--HHHHHHH-------EEEEE--HHH-----------EEHHH-------------------------------------EEEEEE-----EEEEEEE--EEE--HHHHHHHHHH-----EEEEEEE----------EEEEEE--HHHHHHHHHH-----------EE----HH-HHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHH----H--HHHHHHH----------HHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHH---H-------------------------------HHHHHHH-------HHHHHH---HHH---------- CPSF7_3 sspro4 -----------------------HHHHHHHHHHHH-------------------------------------HHH--------------------------------------------------EEEE--------HHHHHHHHHHH----EEEEEEEE--------EEEEEEE--HHHHHHHHHHH----------EEEE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHH--------------------------------------------------------HHH------HHHHHHH-------HHHHHHHHHHHH--- CPSF7_3 psspred --------------------------EEEEEEE-------------------------------------HHHHHH-----------------------------------------------EEEEEE--------HHHHHHHHHHH------EEEEEEE--------EEEEEE--HHHHHHHHHH----------------------HHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHH------HHHHHHHHH------HHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHH-----------HHHHHHHH------HHHHHH-H-HHHHHH--HHHHHHHHHHHHHHHHHHHHH-- CPSF7_3 spineX --------------------EE---EEEEEEEEE----------------EEEE-----------------------------------------------------------------------EEEE---------HHHHHHHH-------EEEEEEEE--------EEEEEE--HHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHH--------------HH---------------------------------------HHH---HHHHH----------------------------- CPSF7_3 raptorxss --------------E-----HHHHHHHHHHHHHH----------------------H------HH-----------------------------------------------------------EEEEEEEE-----HHHHHHHHHH----EEEEEEEE--------EEEEEEEE--HHHHHHHHHH-----------EEEE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HH----------------HH---HHH--------------HH---HHHHHHHHHH--------------------------HHHH---------HHHHHHH--HH---HHHHHHHHH---- CPSF7_3 SPARROW -------------------HHHHHHHHHHHHHHHH------------------------------------------------------------------------------------------EEEEE-------HHHHHHHHHHH---EEEEEEEEEE-----EEEEEEEEE--HHHHHHHHHH-----------E---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HH-----HH--- CPSF7_3 *SPARROW --------------------EEHHHHHHHHHHHHHHHHHHHHHH-----EEEEEE--------HH-HHHHHHHHHHHHH--------HHHHHHHHHH--------------------------EEEEEEE-EEEEE-HHHHHHHHHHH-----EEEEEEE------EEEEEEEEEEEHHHHHHHHHHH---EE---EEEEEEE-HHHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHEEEHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHH---------------HHHH---H----HHHHHHHHH---H---H--HHHHHHHHHHHHHHHHHHHHHHHH CPSF7_3 HMMSTR ---------------------------EE---E----------------EEEEE---------H--------HHHH------------------------------------EEE--------EEEEEE--------HHHHHHHHHH----EEEEEEEEE---------EEEEEE--HHHHHHHHHH------------E--------HH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHH-------HHHHHHH-------HHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHH------------------------------------HHHHHH--------HHHHHHHHHHH--HHHH---- CPSF7_3 porter ----------------HHHHHHHH------EEEEEEE----------EEEEEE--HHHHHHHHHHH---------EEEEE-----HHHHHH-----------HHHHHHHHHHH-----------EEEEEE-------HHHHHHHH-------EEEEEEEE---------EEEEEE---HHHHHHHHHH---------HHHHHH----HHHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHH-------------------------------------------------HHHHHHHHH-------------- CPSF7_3 cdm ----------------HHHHHHHH------EEEEEEE----------EEEEEE--HHHHHHHHHHH---------EEEEE-----HHHHHH-----------HHHH---------------------EEE-------HHHHHHHHH--------EEEEEE------EEEEEEEE-------HHHHHH----EE--EE-EEE---HHHHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHH-------------------------------------------------HHHHHHHHH-------------- CPSF7_3 fdm ----------------------------------------HHHHHHHHHHHHHH-------------------------------------------------------------------------EEE-------HHHHHHHHH--------EEEEEE------EEEEEEEE-------HHHHHH----EE--EE-EEE---HHHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------HHH--------------------------------------------------------------------------------------------------------------------------------- CPSF7_3 gor --------------------------EEEEEEEE--------------HHH----------------------E--EE----------------------------------EEE---------EEEEEE-------HHHHHHHHHH---E-EEEEEEEE--------EEEEEEE--HHHHHHHHHH----------EEEE--------HHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHH-------HHH-----------HHHHHHHHHHHHHHHHH----------EEH--HHHHHHHHHH-----------HHHH-----------HHHHHHHH----------HHHHHHHHHHHHHHHHHHH--- CPSF7_3 spine --------------------------EEEEEEE----------------HHHHH---------------------------------------------------------EEEEE--------EEEEE--------HHHHHHHHHH-----EEEEE-------------EEEEEE----HHHHHHH--------------------HHHHHHH-----EEE----------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHH-------HHHHH---------HHHHHHHHHHHHHHH---------EEEEE--------------------------------------------HHHHH-------HHHHHHHHHHHH---------- CPSF7_3 nnssp --------------------------EEEEEEEEEEEE-----------EEEEE---------------------------------------------------------EEEEE-------EEEEEE---------HHHHHHHHHH----HHHHHHHHHHH------EEEEEEE-HHHHHHHHHH-----------------HHHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHH-----HHHHHHHH-------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------------------------HHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHH-- CPSF7_3 pssfinder --------------------------EEEEEEEE---------------EEEEEE--------------HHHHHHHHHH---------------------------------EEEE----------EEE----EE----HHHHHEE--EEEEEEEEEEEE---------EEEEEE-----HHHHHHH--------------------HHHHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHH-----HHHHHHH----------HHHHHHHHHHHHHH--------EEEEEE---HHH---------EE-------------------------HHHHHHHH------HHHHHHHH-------------- CPSF7_3 sspal --------------------------EEEEEEEEE----------------------------------HHHHHHHHHHH-------------------------------EEEEEEE--------EEEEEEE------EEEEEEE--EEEEEEHHHHHHHHH------HHHHHHHHHHHHHHHHHH---EEEE-----HHHHHHHHHHHHHHHHH---EEEE-------------------------------------------------------------------EEEEEEEE-----EEEEEEE--------EEEE---------------------EEEE-------------------------EEEEHHHHHHHHH------------------HHHHHHHHHHHHHHH-------------EEEEEHHHHH---------EEEE-----------------------HHHHHHHHH---HHHHHHHHH---------------- CPSF7_3 ssp --------------------------EEEEEE-----------------EEEEE------------------------------------------------------------------------EEEE-------HHHHHHHHHHH-------EEEE-----------EEEEE--HHHHHHHHHH------------EE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHH------------HHHHHHHHH------------------------------------------------------------------------------------------------ CPSF7_3 sspred -------------------H-HHHHHHHHHHHHHHH-----------------------------------------------------------------------------------------EEEEE-------HHHHHHHHHHH-----EEEEEEE--------EEEEEEE--HHHHHHHHHHH---------EEEEEE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- CPSF7_3 netsurfp --------------------------EEEEEEEEE-------------------------------------EHHHHH----------------------------------------------EEEEEE-------HHHHHHHHHHH-----EEEEEEE--------EEEEEEE--HHHHHHHHHH------------E------------HHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E---HH--HH--------------HHHHHHHHH---------HH-HH---HHHHHHHHHHH------------------------------------------H----HHHHHHHH--------- CPSF7_3 soprano --------------------------EEEEEEEE------------------------------------------------------------------------------------------EEEEEE-------HHHHHHHHHH-----EEEEEEEE--------EEEEEEE--HHHHHHHHHH-----------EEE--------HHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH---------HH-------------HHHHHHHHHHHHHH-----------HHH--HHHH--------------------------------------------------HHHHHHHHHHHH---------- CPSF7_3 consensus MATEIGSPPRFFHMPRFQHQAPRQLFYKRPDFAQQQAMQQLTFDGKRMRKAVNRKTIDYNPSVIKYLENRIWQRDQRDMRAIQPDAGYYNDLVPPIGMLNNPMNAVTTKFVRTSTNKVKCPVFVVRWTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDSPVRAMTWSHNDMWMLTADHGGYVKYWQSNMNNVKMFQAHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERILRGHGADVKCVDWHPTKGLVVSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKLFDIRNLKEELQVFRGHKKEATAVAWHPVHEGLFASGGSDGSLLFWHVGVEKEVGGMEMAHEGMIWSLAWHPLGHILCSGSNDHTSKFWTRNRPGDKMRDRYNLNLLPGMSEDGVEYDDLEPNSLAVIPGMGIPEQLKLAMEQEQMGKDESNEIEMTIPGLDWGMEEVMQKDQKKVPQKKVPYAKPIPAQFQQAWMQNKVPIPAPNEVLNDRKEDIKLEEKKKTQAEIEQEMATLQYTNPQLLEQLKIERLAQKQVEQIQPPPSSGTPLLGPQPFPGQGPMSQIPQGFQQPHPSQQMPMNMAQMGPPGPQGQFRPPGPQGQMGPQGPPLHQGGGGPQGFMGPQGPQGPPQGLPRPQDMHGPQGMQRHPGPHGPLGPQGPPGPQGSSGPQGHMGPQGPPGPQGHIGPQGPPGPQGHLGPQGPPGTQGMQGPPGPRGMQGPPHPHGIQGGPGSQGIQGPVSQGPLMGLNPRGMQGPPGPRENQGPAPQGMIMGHPPQEMRGPHPPGGLLGHGPQEMRGPQEIRGMQGPPPQGSMLGPPQELRGPPGSQSQQGPPQGSLGPPPQGGMQGPPGPQGQQNPARGPHPSQGPIPFQQQKTPLLGDGPRAPFNQEGQSTGPPPLIPGLGQQGAQGRIPPLNPGQGPGPNKGDSRGPPNHHMGPMSERRHEQSGGPEHGPERGPFRGGQDCRGPPDRRGPHPDFPDDFSRPDDFHPDKR FGHRLREFEGRGGPLPQEEKWRRGGPGPPFPPDHREFSEGDGRGAARGPPGAWEGRRPGDERFPRDPEDPRFRGRREESFRRGAPPRHEGRAPPRGRDGFPGPEDFGPEENFDASEEAARGRDLRGRGRGTPRGGRKGLLPTPDEFPRFEGGRKPDSWDGNREPGPGHEHFRDTPRPDHPPHDGHSPASRERSSSLQGMDMASLPPRKRPWHDGPGTSEHREMEAPGGPSEDRGGKGRGGPGPAQRVPKSGRSSSLDGEHHDGYHRDEPFGGPPGSGTPSRGGRSGSNWGRGSNMNSGPPRRGASRGGGRGR WDR33_1 sequence ------------------------------HHHHHHHHHHH--------------------HHHHHHHHH---------------------------------------HHEE--------EEEEEE-----EEEE-----EEEEE-------EEE--------EEEEEE----EEEE------EEEE------HHHH--------EEEE------EEE-----EEEEEE----EEEEEE-----------------EEEE--------EEEE--------EEE------EEEEEE-----EEEEE-----HHHHHHHHHHHHHHHH--------EEEEE---------------EEEEE----------------------------EE---------EEEE--------------------------------------------HHHHHHHHHHH--------------------HHHH-------------------HHHHHH------------------HHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- WDR33_1 psipred ------------------------------------------------------EEEE---HHHHHHHHHH----------------------------------EEEEEEEE--------EEEEEE-----EEEEE----EEEEE------HHHHHHHHHHHHEEEEE-----EEEE-----EEEEEE-----EE----HHHHHH----------EEEE----EEEEEE-------EEE-------EEE-------EEEEE-------EEEE-------EEEE-----EEEEEEEE----EEEEE----EEEEEEHHHHHHHHHHH-------EEEEE------EEEE-----EEEEEEE---------HHHHHHHHHH-------EEEEE--------EE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ WDR33_1 prof --------------------------------------------------------EE---HHHHHHHH--------------------------------HHHHHHHHHHHHHHH----EEEEEEE-----EEEEE----EEEEE------HHHHH-------EEEEE----EEEEE----EEEEEE--------EEE-----EEEEEEE--------E-----EEEE-------HHHHH--------EEE----EEEEE-------EEEEEE------EEEEE-----EEEEEEE----HHHHHHHHHHHHHHHHHHHHH--EEE---------EEEEEEE---EEE----EEEEEEE---------HHHHHHHHHHH--------EEE------EEEEEE-----------------------------------EE----------------EEE----------------------------------E----------------------------EE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- WDR33_1 jnet --------------------------------------EEE--------------EEE---HHHHHHHH-------------------------------------HHHHHHH-------EEEEEEE-----EEEEE----EEEEEE----EEEEEEE-----EEEEEEE----EEEEE----EEEEE------EEEE------EEEEEE-----EEEEE----EEEEEE-----EEEEE-----EEEEEEE-----EEEE-------EEEEE-------EEEE------EEEEEE-----EEEEE----EEEEEE--------EEE------EEEEEE------EEEE-----EEEEEEE-----EEE-HHH---HEEEEEE-----EEEE-----EEEEEE------------------------------------EE---------EEE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- WDR33_1 sable -------------------------------------------------------EEE----HHHHHHHH--------EEEE-----EEEE--------------HHHHHHHH--------EEEEEEE---EEEEEEE---EEEEEEE---EEEEEEE----EEEEEEEE---EEEEEEE---EEEEEE---EEEEEEE----EEEEEEEE----EEEEEE---EEEEEEE--E--EEEEE---EEEEEEEEE--EEEEEEEEE----EEEEEE----EEEEEEE---EEEEEEEEE---EEEEEEE---EEEEEEE------EEEEE----EEEEEEE------EEEEEE---EEEEEE---EEEEHEEEE-----EEEEEE----EEEEEEE---EEEEEE-----E----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- WDR33_1 proteus ----------EEEEE----------------------EEEE-----EEEEE----EEEEE-----EEEEEE-----EEEEEE-----EEEE-----EEEEE-----EEEEEE---------EEEEEE-----EEEEE----EEEEEE-----EEEEEE-----EEEEEE-----EEEE-----EEEEEE-----EEEEE-----EEEEEE-----EEEEE----EEEEEE-----EEEEE------EEEEEE-----EEEEE------EEEEEE-----EEEEE------EEEEEE-----EEEEE----EEEEEE------EEEEE------EEEEEE-----EEEEEE----EEEEEE-----EEEEEE-----EEEEEEE-----EEEE-----EEEEEE------EE------EEEEEE-----EEEE-----EEEEEE-----EEEEEE----EEE------EEEEE-----------------------------HHHHHHHHH---------HHHH--HHH--HHHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHH----------------------------------------------HH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H--------------------------------------------------------------------------------------------HH--------------------------------------------------------------------HHH---------------- WDR33_1 sspro4 -------------------------------------------------------EEE---HHHHHHHHH---------EEE------EE-----------------EEEHHHH-------EEEEEE-----EEEEE----EEEEEE-----EEEEEE-----EEEEEE-----EEEEE----EEEEE-----HHHHHHH----EEEEEE-----EEEEE----EEEEEE----EEEEEEEE----EEEEEE-----EEEEE-------EEEEE-----EEEEEE-----EEEEEEE----EEEEEE---EEEEEE-------EEEEE-----EEEEEE------EEEEE----EEEEEE------EEHHH------EEEEEE-----EEEEE----EEEEEE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- WDR33_1 psspred -----------------------------HHHHHHHHHHHH--------------EE---HHHHHHHHHHH--------------HHHHHH----------HHHHHHHHHHHH--------EEEEEE----EEEEEE----EEEEE------EEE--H-------EEEEE----EEEEEE---EEEEEE--HHHHHHHHH------EEEEE-----EEEEE---EEEEEE----EEEEEEE-----E-EEE------EEEE-------EEEEE------EHHHHHH----E-EEEEE---EEEEEEE---EEEHHHHHHHHHHHHHHH-----E-EEEEE-----EEEE-----EEEEEE------------HHHHHHHHHHH-----EEEE-----EEEEEE---------------------------------------------HHHHHHHHHHH------------------HHHHHHHHH--------------------------------------------HHHHHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- WDR33_1 spineX -------------------------------------------------------EE---HHHHHHHH--------------------H--------------------EEE----------EEEEE-----EEE------EEEEE------HHHHHHH---HHHHHE------EEEE------EEEEE-----HHHHHH-HHHHHH-----------E-----EEEEE-----EEEEEE------------------EEE--------EEEE-------HHEHH-----EEEEEE-----EEEEE----EEEEE--------EEEE--------EEEE----------------EEEEE-----------------E----------EE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ WDR33_1 raptorxss -------------------------------------------------------EEE--HHHHHHHHH-----------EE-----HHH-----HH-----HHHHHHHHHHH--------EEEEEE----EEEEEE----EEEEE------EEEEE------EEEEEE-----EEEEE----EEEEE-----EEHHEE-----HEEEEE-----EEEEEE---EEEEEE--H-EEEEEE------EEEE-----EEEEEEE-------EE-E------EEEHHHH----EEEEEE-----EEEEEE---EEEHHHHH----HHHEEE-----EEEEEE------HEEE-----EEEEEE------H-EE---HHHHEEHHH------EEEE-----EEEEEEE-------HHH-H-----HHH-----------HHHHHH-------------------------------------------------------------------E---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E---EEEEE--EEEE-----------------------------------------------------------------------------------------------------------E-E----------------------------------------------------------------- WDR33_1 SPARROW --------------------------------HH---------------------------HHHHHHHHH----------------HHHHH------------------EEE---------EEEEEE-----EEEE-----EEEEE----E-HHHHHHH-----EEEEEE----EEEEE----EEEEE------H-HHH-----------------EE------EEEEE------HHEE---------EE-E-----EEEE-----------E------EEEEH------EEEEEE-----EEEEEE---HHHHHHHHHHHHHHEEE------EEEEEE------EEEE------EEEEE--------------HHHHHHHHH-----EEEE------EEEEE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- WDR33_1 *SPARROW ------------------------------HHHHHHHHHH----HHHHHHHHHHHEE-HHHHHHHHHHHHHH--------------HEHHHH------------EEEEEEEE-----EE--EEEEEE-----EEEE----EEEEEEE--EEEHHHHHHHHHHHEEEEEE-----EEEE------EEEE------HHHHHHHHHHHHHHH----H-EEEEE----EEEEEE---HHHHHHH------EEEEE-----EEEEE-------EEEEE------EEEEEEE---EEEEEEE-----EEEE--HHHHEEEE-HHHHHHHHHHHH------EEEEE------EEEE------EEEEEE-----HHHHHHHHHHEEEEEEE----EEEEE-----EEEEEE----------H-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E WDR33_1 HMMSTR -----------------------HH------------EEEEEE---EEEE------EEEE-----HEEE-------EEEEEE------EEE------E--------EEEEEEEE-------EEEEEE-----EEEEEE---EEEEEE-----EEEEEE-----EEEEEE-----EEEEEE----EEEEE----EEEEEE-----EEEEEE-----EEEEEE----EEEEE-----EEEEE------EEEEEE-----EEEEEE-----EEEEEE-----EEEEE------EEEEEE-----EEEEEE---EEEEEE-----EEEEEE------EEEEEE-----EEEEEEE----EEEEE-----EEEEEE------EEEEEE-----EEEEEE---EEEEEE------EEE----EEE--------EEEEEE----EEEEEE-----EEEEEE-------------EEEE------------------------------HHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- WDR33_1 porter --E-------------------HHH-----HHHHH-----E----EEEEE-----EEE----EEEEEEE-------EEEEEE-------------HHH---HHHH----EEEEE-------EEEEEE-----EEEEE----EEEEE------EEEEEEE----EEEEEE-----EEEE-----EEEEE-----HHHHH-------EEEEE-----EEEEE----EEEEEE----EEEEEEE-----EEEEEE-----EEEEE-------EEEE------EEEEE------EEEEEE-----EEEEEE---EEEEEE--------EEE------EEEEEE-----EEEEEE----EEEEEE--------HHHHHH---EEEEEE-----EE--------EEEEE---------------------------------------------------------------------------------------------------HHHHHHHH-------------------EEHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ WDR33_1 spine ---------------------------------HHHHHHHH-----HHHHH-----------HHHHHHHH--------------------------------------EEEE---------EEEEEE-----EEEE------EEEE------HHHHHH----------------EEEE------EEEE------HHHHHHHHHHHHH---------EEE------EEEEE---------------------------EEE----------------------EE------EEEEEE-----EEEE-----HHHHH----HHHHHHHHH-------EEE-----------------EEEEE-----------------EE---------EEE---------EE-----------------------------------EEE---------HHHHHHH----------EEEE--------HHHHH------------------------------------------------------HHHHHHHHHH------HHHHHHHHHHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ WDR33_1 nnssp ---------EEEEE-----------------HHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHHHHHHHH----------------------EEEEEEEE---------EEEEEE-----EEEE-----EEEEEE-----HHHHHHH----EEEEEE-----EEEE-----EEEEEE-----HHHHHHHHHHHHHH-------EEEEEE------HHHHHHHHHHHHHHHH--EEEEEEE-----EEEE--------EEEE------EEEEEEEE--EEEEEEEE----EEEE--HHHHHHHHHHHHHHHHHHHHH--------------------------EEEEEEEEEEEEE--HHHHHHHHHHHHH------EEEE-------EEEEEE-------------------------------EEEEE-----HHHHHHHHHHHHH------------------HHHHHHHHHHH-------------HHHHHHHHH---------------HHHHHHHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHH----------------------------------------HHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- WDR33_1 pssfinder -----------EE----------HHH------HHHHHHHHHHHHHHHHHHHHH------------HHHHHHHHHHHH-HHHH---------------EE-------EEEEEE--------EEEEEEE----EEEEE-------EEEE-----HHHHHHH----EEEEE-----EEEEE-----EEEEEE-----HHHHHHHHHHHHHH-------EEEE-----EEEEEE----HHHHHH-----EEEEEE-----EEEEE--------EEE--------EEEE------EEEEEEE------EEE---EEEEEEE---HHHHHHHHH-----------------EEE------EEEEEE------EEEEEEE----HHH--HHHHHHEE---------EE--------------------------------------EE--------HHHHHHHH---------EEEE---------HHH-------------------HHHHHH-----------EEE-------EEEEHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- WDR33_1 sspal ------------HHHHHHHHH-----------HHHHHHHHHEEE-HHHHHHHHH--------HHHHHHHHHHHH-------------------------------EEEEEEE-----EEEEEEEEEEE--------------EEEEEEEEEHHHHHHHHH---EEEEEEE-------------EEEEHHHHHHHHHHHHHHHHHH-------------------EEEHHHHHHHHHHHHHH-----EEEE----EEEEEEE-----------------HHHHHHHHH---EEEEEEEEE--HHHHHHHHHHHHHH-HHHHHHHHH----HHHHHHHHHH----------------EEEEEEE-----------------------EEEEEEE----------------HHHHHHHHH--------------------EEEE------HHHHHHHHH---------EEEEEEE--HHHHHHHHHH---------------HHHHHHHHHHH---------HHHHHHHHH--HHHHHHHHHHHHHHHHHEEEHHHHHHHHHH-HHHHHHHHHHHH----------------------------------HHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHH------------- WDR33_1 ssp ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ WDR33_1 sspred ---------------------------------H----------------------E----HHHHHHHHH-----------------------------------H-HHHHH---------EEEEEE-----EEEE------EEEE------HHHHHH------EEEEE-----EEEE-----EEEEE------H-------------E--------EE-----EEEEEE-----EEEEE--------EE-------EEEEE-------EEE--------HHHHH-----EEEEEE-----EEEEE-----EEHHHHH--HHHHHH---------EEEE-------EEE-----EEEEEE-----------------EEEE-------EEEE-----EEEEE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ WDR33_1 netsurfp -------------------------------H-----------------------EEE---HHHHHHHHH-----------E--------------------HHHHHHHHHHHH-------EEEEEE-----EEEEE----EEEEE-------EEEEEE----EEEEEE-----EEEEE----EEEEE------H-EHH--------EEE------EEE-----EEEEEE------EEEE-----EEEEE------EEEEE--------EEEE-------HHHHHH----EEEEEE-----EEEEE----EEEEEEHHHHHHHHHHHH-----EEEEEE------EEEEE----EEEEEE--------E--------EEEHHH----EEEEE------EEEEE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- WDR33_1 soprano -------------------------------------------------------EE----HHHHHHHHH-------------------------------------EEEEE---------EEEEEE-----EEEEE----EEEEE------H--HHH-----EEEEEE-----EEEE-----EEEEE------HHHHH-----HEEEEE------EEEE----EEEEEE-----EEEEE------EEEEE------EEEE--------EEEE-------EEEE------EEEEEE-----EEEEE----EEEEEEHH-HHHHHHEE-------EEEEE------EEEE-----EEEEEE-----------------EEEE-------EEEE------EEEEE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- WDR33_1 consensus MSCVHYKFSSKLNYDTVTFDGLHISLCDLKKQIMGREKLKAADCDLQITNAQTKEEYTDDNALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPAMATTKAIDDSSASISLAQLTKTANLAEANASEEDKIKAMMSQSGHEYDPINYMKKPLGPPPPSYTCFRCGKPGHYIKNCPTNGDKNFESGPRIKKSTGIPRSFMMEVKDPNMKGAMLTNTGKYAIPTIDAEAYAIGKKEKPPFLPEEPSSSSEEDDPIPDELLCLICKDIMTDAVVIPCCGNSYCDECIRTALLESDEHTCPTCHQNDVSPDALIANKFLRQAVNNFKNETGYTKRLRKQLPPPPPPIPPPRPLIQRNLQPLMRSPISRQQDPLMIPVTSSSTHPAPSISSLTSNQSSLAPPVSGNPSSAPAPVPDITATVSISVHSEKSDGPFRTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQKVKSVTV RBBP6_4 sequence ---EEEEE-------EEEE------HHHHHHHHHHH---------EEEE-------------------EEEEEEEE----------EE-------------------HHHHHHHHHHHHHHHH---HHHHHHHHHHH-------------------------------------------------------------------------EE-----EEE----HHHHHH--------------------------------------------------HHHHHHHHHH----------------------HHHHHHHHHHHHH--HH------------------------------------------------------------------------------------------------------------------------------------------HHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH-----------------------------------------------------------------------------------------HHHHHHHH--------------------------------------------------HHHHHHHHHHHHHHHH--------------HHHHHHHHHHHHH--------HHHHHH------------ RBBP6_4 psipred --EEEEEEE------EEEE---EE-HHHHHHHHHHHH--------EEEE-------------EE----EEEEEEE-----------EEE-------------------------------------HHHHHHHHHHHHHH------------------EEEEE------EE------------------------HHHHH---------EEEE----EEEEE--HHHHHHHHHH---------------------------HHHHH-------------HHHHHHHHHH-----------------------HHHHHHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_4 prof ---EEEEEE---------------HHHHHHHHHHHH--------EEEEE------------EEEE---EEEEEEE--------------------------------------------------HHHHHHHHHHH----------------------EEEEE----------------------------------------------EEE-----EEEE-HHHHHHHHHHH------------------------------------EE---------HHHHHHH-------------------------HHHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEEEE---------------------------------------EEE---------------------------------- RBBP6_4 jnet --EEEEEE-------EEEE----EEHHHHHHHHHHH--------EEEEEE------E-----EE----EEEEEE----------------------------------------------------HHHHHHHHHH-----------------------EEEE--------------------------------HHHHH---------EEE-----EEEE---HHHHHHHH------------------------------HHHHHH------------HHHHHHHHH-----------------------HHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_4 sable -EEEEEEE----EEEEEEEE-EEE-HHHHHHHHHHHH------EEEEEEE----EEE----EEEE--EEEEEEEEEE---------EE-----------------------------HHHHHHHHHHHHHHHHHHHHHHHHHH----------------EEE-----------------------------------------------EEEE---EEEEE---HHHHHHHHHHHHHHHHHHHH------------------------------------HHHHHHHHH------------------------HHHHHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_4 proteus --EEEEEEE------EEEE------HHHHHHHHHHHHH--------EE------HH----H-------EEEEEE-----------EEEE---------------------HHHH--HHHHHH----HHHHHHHHHH----------H------------EEE-------EEE-----------------------HHHH------------E-----EEE--HHHHHHHHHHH-------H--------------------HHHH----EE---------HHHHHHHHH----------------HHH----HHHHHHHHHHHHH----------------------HHHHHH-----------------E-------------------------------------------EEEEE----------------------------HHHHHHHHHHHH----------EEEEEE--------------HH---------------------------EE----------------------EEEEEEE------------------------------------------HH--------EE-------------------------------EE---------H----------------------------------------------------------------------------------HHHHEEE------------------------E--------------------------------------------------EE----------HH------------H-HHEEH----------------------------------------------------------------------EEE---------------------H-------------- RBBP6_4 sspro4 --EEEEEEE------EEEE------HHHHHHHHHHHH-------EEEEE-------------EE----EEEEEEE---------------------------------------------------HHHHHHHHHHHH------------------------------------------------------------------------EE-----EEEE---HHHHHHHHHH-----------------------------HHH---EE---------HHHHHHHHHH----------------------HHHHHHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_4 psspred -EEEEEEE------EEEEE------HHHHHHHHHHHH------EEEEEEE-----------E------EEEEEEE----------EEE----------------------HH-----HHHHHH---HHHHHHHHHHH---------------------EEEE-------E-------------------------HHH--E--------EEEE---EEEEEE--HHHHHHHHHH------------------------------H-----E--------HHHHHHHHHHH----------------------HHHHHHHHHHHHHH-HHHH----------------------------------------------------------------------------------------------------------------------------HHH-----------HHHH---------------HHH-------------------------------------HHHHHHH--------HHHHHHHH------------------HHHH--HHH---------HHHHHHHHHH------------------------------------------HHHHHHHHHHHHHHHHHH-----------HHH----HHHH-------------------------------------------------HHH-HHHHHH------------------HHHHHH-----------------------------HHHHHH--------HHH---HHHHHHH------HHHHHHHHHHHHHHHHHH-------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------- RBBP6_4 spineX --EEEEE--------EEEE------HHHHHHHHHHHH--------EEEE-------------E-----EEEEEE------------EEE------------------------------HHH----HHHHHHH------------------------------------EEE--------------------------------------EE-----EEE-------H--------------------------HHHH------------E-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E------------------EE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_4 raptorxss -EEEEEEE------EEEEE------HHHHHHHHHHHH-------EEEEEE-----------EEE----EEEEEE---------------------------------------------HH-----HHHHHHHHHHHHHHH--H-------------------------------------------E-------HHHEEE--------EEEE----EEEE---HHHHHHHHHH-------------HHHH-------------H----EE---------HHHHHHHHH-----E-----------------HHHHHHHHHHHH----HH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HH-----------------------------------------------------------------------------------------------------------------------------------HH--------------------------------------------------------------------------------HH-----------------------------------------------------------------------------------------------------H------------------------------HHH----------------------------------------H-HHH--HHHHH----- RBBP6_4 SPARROW --EEEEEE-------EEEE------HHHHHHHHHHHH-------EEEEE------EE----EEE----EEEEEE----------------------------------------------------HHHHHHHHHHHHHHH------------------E-----------------------------------HHH-----------EEE-----EEEE---HHHHHHHHHH-----------------------E------E----E----------HHHHHHHHHH----------------------------HHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_4 *SPARROW --EEEEEEEE-----EEEEE--EEEEHHHHHHHHHHHH-----EEEEEE------EE-----E-----EEEEEE-----------EEEEE------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----------------H--H---EEEE--------------HEE------HHHHHHE------EEEE-----EEEE---HHHHHHHHHHHHHHHHHHHHHHHHH-----HHEE----HHHHH--------HHHHHHHHHHHHHHHH-----HH-H-----EH--E-HHHHHHHHHHHHHHH-HH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH-------------H----HHHHHHHHHHHH-HH-------------------------EE RBBP6_4 HMMSTR -EEEEEEE-----EEEEEE---EEEHHHHHHHHHHHH------EEEEEEE-----EE-----EEE----EEEEEEE----------EEE-------------------------------------HHHHHHHHH-----------------------------------HHH--HHH----------------------------------------E-----HHHHHHH-----------------------HHH------------EE------EE---HHHHHHHH---------------HH-----HHHHHHHHHHHHH-----------------------------------------------------------------------------------------EEEEE---------------------------------------------------EEE------------------------------------------------------------------------------------------------------------------------H--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHH----------------------------------------- RBBP6_4 porter ----EEEE------EEEEE----HHHHHHHHHHHHHHHH-----HHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_4 cdm EEEEEEEE-----EEEEEE---EEEHHHHHHHHHHHH------EEEEEEE-----EE-----EEE----EEEEEEE----------------------------------------------------------------------------------------------HHH--HHH-------------------------------------------------------------------------------------------EE------EE-HHHHHHHHHH-------------------EE-HHHHHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_4 fdm EEEEEEEE-----EEEEEE---EEEHHHHHHHHHHHH------EEEEEEE-----EE-----EEE----EEEEEEE-----EEEEEEEHHH-------------------------EEEEEEE------EEEE-------------------------------------HHH--HHH---------------------------------HHHHHHHH---------------------HHH--HHHHHHHHH---------------EE------EE-HHHHHHHHHH-------------------EE-HHHHHHHHHHHHHH------------------------------------------------------------------------------------------------EEEE--EEEEEEE----------------EEEE--HHHHHHHH--HHHHHH----HHHHHH-----HHHHHH--HHHHH--------------------------------------------------------------------------HHHHHHHHHH--EEEEEEE---HHHHH--HHHHHHHHH-------EE-----EE------HH-----------HHH-HHH-----EEEE-------------HHH--EEEE----HHH------------EEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_4 gor EEEEEEEE--------EEE---EEEE---HHHHH-----------EEEE--------------------EEEEEEE---------EEEEE------------------EEHHHHHHHHHHHHH----HHHHHHHHH-----------------------EEEE----------------------------------EEEE--------EEE------------HHHHH--------------------------HHHHHHH-------EEEE----------HHHHHH------------------HHHHHHHHHHHHHH-----------------------------------------------EEEEE----------------------------------------EEEEEEE-----------------------------HHHHHHHHHH----------EEEEEE----------HHHHH-----------------EEE--------EEE---------HHHHHHHHHHHHHHHHHHH------------------EEEE--------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHH----------EEEEE----------------------------------------------------------EEEE---------HHHHHHHHHHHHHHH---EEEEEEE---------------------------------------HHHHHHHHHHH----------------EEEEE-----------------HHHHHHH----EEEEEE RBBP6_4 nnssp ---------------EEEE--EEEEHHHHHHHHHHHHHHHH----EEEE-------------------EEEEEE------------EEEEE--HHHHHHHHHH-------HHHHHHHHHHHHH---HHHHHHHHHHH----------------------------------------------------------HHHHHHH------EEEEE-----------HHHHH-------------------------HHHHHHHHHHH----EEEE-------HHHHHHHHHH---------------HHHHHHHHHHHHHHHH--------HHHHHH---------------------------------EEEEE--------------------------------------EEEEEEEEEEE------EEE-----------------HHHHHHHHHH--------HHHEEEEEE-------------------------------EEEE-------------------HHHHHHHHHHHHHHHHHHHHHH----------------HHHHHHH----------------HHHHHHH---------------------------------------------------------------------------------------------------------------------------------------EEEEEE-------EEEEEE-----HHHHHHHH----------------------------------------------------------HHHHHHHHHHHHHHHHHHHEEEEEEE-----------------------------------HHHHHHHHHHHHHH----------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-- RBBP6_4 pssfinder ----EEEE--------EEE---EEEEEEEEEEE----EEE-----EEE-----EEEE------------EEEEE-----------EEEEE-----EE-----------HHHHHHHHHHHHHHH---HHHHHHHHHH----------------------EEEEE------EE---------------EEEEEE-----EEEEE--------EE-----EE-----HHHHHHHHH---------------------HHHHHHH-------EEEEE----------EEEEEEE-----------------HHHHHHHHHHHHHHH-----HHHHH------------------HHHHHHH--EEE-------EEEE-----------EEEEE-----------------------EEEEEE------------------------------HHHHHHHHHHH---------EEEEEEE---------HHH--------------------EEE------EEEEE---------HHHHHHHHHHHHHHHHHHH----------------HHHHHHHH--------------HHHHHHHH-----------HHH------------------------EE-----------------------------------------------------------------------EEEE-------HHHH--------HHHHHHHH--------EEEEEE--------EE-EE------------EEEE--HHHHHHHHHHHHH---------------------------HHHHHHHHHHHHHHH-----EEEEE--------------------------------------------HHHHHH----------------HHHHHHHHH-------------HHHHH------EEEEEE RBBP6_4 sspal --EEEEEEE----EEEEEEE-EEEEHHHHHHHHH-----------EEEE--------------------EEEEEEE---EEEEEEEEEEE----------------HHHHHHHHHH---HHHHHHHHHHHHHHHH-----------------------EEEEE--------------------------------EEEEEEEE------------------HHHHHHHHH------------------------HHHHHHHHH-----EEEE---------HHHHHHHHH----------------HHHHH-HHHHHHHHHHH----HHHHHHHHH------------HHHHHHHHHHH---------EEEEEEE------------------------------------EEEEEEEEEE---------------------------HHHHHHHHHHH----------EEEEEEE------------------------------------------EEEE--------HHHHHHHHH--HHHHHHHHH-------------------------------------HHHHHHHHHH------------------------------------------------HHHHHHHHH--------------------------------------------------------------------------HHHHHHHHH--------EEEEEEE--HHHHHHHHHEEEEE---------------------HHHHHHHHH-----------EEEE-----------HHHHHHHHHHH------EEEEEEE-------------------------------------------------------------------------------------HHHHHHHHH---------- RBBP6_4 ssp -------------------------HH-HHHHH---------------------------------------------------------------------------------------------HHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------HHH--------------------------HHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_4 sspred --EEEEEE--------EE-------HHHHHHHHHHHH------EEEEEE-------------EE----EEEEEE-----------EEEE------------------------------HHH-----HHHHHHHHHHH--------------------EEEE-----------------------------------------------EEE-----EEEE---HHHHHHHHHHHHH--------------------------------EEE---------HHHHHHHH-----EE----------------HHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_4 soprano --EEEEEE-------EEEE----E-HHHHHHHHHHHH-------EEEEE-------------EE----EEEEEEE-----------EE-------------------------------HHH----HHHHHHHHHH-----------------------E-------------------------------------------------EEE-----EEE----HHHHHHHHH------------------------------------EE---------HHHHHHHHH-----------------------HHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_4 consensus MADGVDHIDIYADVGEEFNQEAEYGGHDQIDLYDDVISPSANNGDAPEDRDYMDTLPPTVGDDVGKGAAPNVVYTYTGKRIALYIGNLTWWTTDEDLTEAVHSLGVNDILEIKFFENRANGQSKGFALVGVGSEASSKKLMDLLPKRELHGQNPVVTPCNKQFLSQFEMQSRKTTQSGQMSGEGKAGPPGGSSRAAFPQGGRGRGRFPGAVPGGDRFPGPAGPGGPPPPFPGNLIKHLVKGTRPLFLETRIPWHMGHSIEEIPIFGLKAGQTPPRPPLGPPGPPGPPGPPPPGQVLPPPLAGPPNRGDRPPPPVLFPGQPFGQPPLGPLPPGPPPPVPGYGPPPGPPPPQQGPPPPPGPFPPRPPGPLGPPLTLAPPPHLPGPPPGAPPPAPHVNPAFFPPPTNSGMPTSDSRGPPPTDPYGRPPPYDRGDYGPPGREMDTARTPLSEAEFEEIMNRNRAISSSAISRAVSDASAGDYGSAIETLVTAISLIKQSKVSADDRCKVLISSLQDCLHGIESKSYGSGSRRERSRERDHSRSREKSRRHKSRSRDRHDDYYRERSRERERHRDRDRDRDRERDREREYRHR CPSF6_2 sequence -------------------------------------------------------------------------------EEEEEEE-------HHHHHHHHHH-----EEEEEEEE---------EEEEEE--HHHHHHHHHH--------------------HHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHH--------HHHH-----------HHHHHHHHHHHHHH---------HHHHHHHHH-----------------------------HHHH------------HHHHHHHHHHH---------HHHHHHHHHH--- CPSF6_2 psipred -------------HHHHH-------------------------------------------------------------EEEEEEE--------HHHHHHHHH-----EEEEEEEEE--------EEEEEE--HHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHH-------------EEEE-------------------------------------------------------------------------------- CPSF6_2 prof --------------------------------EEEEE-------------------------------------------EEEEE------HHHHHHHHHHHHH-----EEEEEE---------EEEEEEE---HHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- CPSF6_2 jnet --------------HHHHH------------HHHHH-------------------------------------------EEEEEE--------HHHHHHHHHH------EEEEEEE---------EEEEE----HHHHHHHHH-----------EE---------HH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHH-----------------------------HHHHHHHHHH------------------------------------------------------------------------------------------------ CPSF6_2 sable -------------------------------------------------------------------------------EEEEEE--------HHHHHHHHHH-----EEEEEEEEE--------EEEEE---HHHH-----------------EEE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH---------------------HHHHH----------------------HHHHHHHHH-HHHHH---HHHHHHHHH---------------------------- CPSF6_2 proteus ---------EE----HHHH-HHH--------HHHH------------------------------------EEEEE---EEEEEE--------HHHHHHHHHH----HHHHHHHHHHHH------EEEEEE--HHHHHHHHHH----EE-----------HHHHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHH------HHHHHHHH----------HHHHHHHHHHHHHH-H--HHHHHHHHHHHHHHHH--HHH------------------------------------HHHHHHHHHHHHH-------HHHHHHHHHH--- CPSF6_2 sspro4 --------------------------------------------------------------------------------EEEEE--------HHHHHHHHHHH----EEEEEEEE---------EEEEEE--HHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EE---------------------------HHHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHH--- CPSF6_2 psspred -------HHHH----HHHHHHH--------------E-----------------------------------------EEEEEEE--------HHHHHHHHHHH------EEEEEEE--------EEEEEE--HHHHHHHHHH------------E---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHH-----HHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH- CPSF6_2 spineX ---------------HHH-----------E--------------------------------------------------EEEEE--------HHHHHHHHHH------EEEEEEE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHH--HHHHHHHHHHHH------HHHHHHH--HHHH-------------HHHH---- CPSF6_2 raptorxss ---------------HHHH-----------E----EE------------------------------------------EEEEEEEEE-----HHHHHHHHHH------EEEEEEE--------EEEEE----HHHHHHHHHH-----------EEE------HHH---HH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHH--HH---HHHHH-------------------------------------H------HHHHHH----HHHHHHHHHH-HHHHH---------HHHHHHH---- CPSF6_2 SPARROW ---------------HHHH------------------------------------------------------------EEEEEE--------HHHHHHHHHHH----EEEEEEEEE----------E---------HHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-----------------------HHH----- CPSF6_2 *SPARROW ------EEEEEE-HHHHHHH-HHH-HHHHHHHHHHHH------------------------------------------EEEEEEEEEEEEE-HHHHHHHHHHH----EEEEEEEE-------E--EEEEEEEHHHHHHHHHH-----E----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHH-----HHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHH------------HHHHH-----HHHHH-H--------H-HHH-HHHHH-HHHHH-H---HHHHHHHHHHHHHH CPSF6_2 HMMSTR ------EEEEEE-HHHHHHH---------------------------------------------------EEEEE---EEEEEE--------HHHHHHHHH-----EEEEEEEEE--------EEEEEEE--HHHHHHHHHH-----------EE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHH------HHHHHHHH-----------HHHHHHHHHHH----------------------------------HHHHH-------------------------------------------------HH----- CPSF6_2 porter ----HHHHHHHH--HHHHHHHHHH--------HHH------------------------------------EEE-----EEEEEE-----E--HHHHHHHHHH-----EEEEEEEE---------EEEEEE--HHHHHHHHHH----------------------HHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHH---HHHHHHH-----------HHHHHHHHHHHHH-----HHHHHEEEEEEHHHHHH-----------HHHHHHHHHHHHHHHHHHHHH-HHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--- CPSF6_2 spine -------HHHHHH----------------------------------------------------------EEEE----EEEEEE---------HHHHHHHHH------EEEEEE----------EEEEE------HHHHHHH-------------------HHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHH-------HHHHHHH---------HHHHHHHHHHHH-----------EEEE-----------------------------------------------HHHHHHH-HHHHHHH-----HHHHHHHHHHHHH- CPSF6_2 nnssp ------EEEEEEE--HHHHHHHHH----EEEEE--------------------------------------EEEEEE--EEEEEEE-------HHHHHHHHHHH-HHHHHHHHHHHHHH------EEEEEE--HHHHHHHHHH-----------------HHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHH-----HHHHHHHHHHHH-------HHHHHHHHHHHHH----HHHHHHHHHHHHHHH-------------HHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-- CPSF6_2 pssfinder HH----EEEEEEE-------HHHH-----EE-EEEE----------------------EE-----------EEEEE----EEEEE--------HHHHHHHHHHH------EEEEE---------EEEEEE-------HHHHH------------------------------------------------------------------------------------------------------------EEE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHH-----HHHHHHHHHH-------HHHHHHHHHHHHH---------EEEEEEE--HHHH-------------------------------------------------------------------------- CPSF6_2 sspal -------HHHHHHHHHHHHHHHHH-----------------------HHHHHHHHH---------------EEEEEEE-EEEEEEE------HHHHHHHHHHH------HHHHHHHHHH------EEEEEEEHHHHHHHHHHHH----------EEEE-HHHHHHHHHH--------------------------------------------------------------HHHHHHHHH-----------------------------------------------------EEEE--------------------------------------------------------------------------EEEE-------------------------------------------------------------------------HHHHHHHHH-------HHHHHHHHHHH-----HHHHHHHHH---------HHHHHHHHHHHHHH---------------------------------------------------------------------------- CPSF6_2 ssp -----------------------------------------------------------------------------------------------HHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- CPSF6_2 sspred ---------------HHH-------------------------------------------------------------EEEEEEE-------HHHHHHHHHH------EEEEEE----------EEEE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- CPSF6_2 netsurfp ---------------HHH-------------EEH-EHH-----------------------------------------EEEEEE--------HHHHHHHHHHH-----EEEEEEE--------EEEEEEE--HHHHHHHHHHH----------EEE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHH--------HHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHH------------------------------------HHHHHHHHH----HHHH---------HHHHH--- CPSF6_2 soprano ---------------HHH-------------------------------------------------------------EEEEEE--------HHHHHHHHHH------EEEEEEE---------EEEEEE--HHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH---------HHH-------------HHHHHHHHHHHH---------------------------------------------------------------HHHHHH-------------------HHHH---- CPSF6_2 consensus MQEIIASVDHIKFDLEIAVEQQLGAQPLPFPGMDKSGAAVCEFFLKAACGKGGMCPFRHISGEKTVVCKHWLRGLCKKGDQCEFLHEYDMTKMPECYFYSKFGECSNKECPFLHIDPESKIKDCPWYDRGFCKHGPLCRHRHTRRVICVNYLVGFCPEGPSCKFMHPRFELPMGTTEQPPLPQQTQPPAKQSNNPPLQRSSSLIQLTSQNSSPNQQRTPQVIGVMQSQNSSAGNRGPRPLEQVTCYKCGEKGHYANRCTKGHLAFLSGQ CPSF4_1 sequence --------------HHHHHHHH-------------------HHHH-----------------------HHHH---------------------------------------------------------------------------------------------------------------------------------HHHH-------------------------------------EEEEE---------------------- CPSF4_1 psipred --EEE-----EEEEEHHHHHHHH--------------HHHHHHH---------------------EEEHHHHHHH--------------------EEEEE-----------EEE----------HHH----------------HHHHHHHHH------------------------------------------------------------------------------------------EEEEE---------------------- CPSF4_1 prof --------------HHHHHHHHH----------------------------------EE-----EEEEE--------------E----------EEEEEE---E-------EEEE---------HHHHH-------------------HHHH-----------------------------------------------------------------------------------------EEEEEE-----EEE-------------- CPSF4_1 jnet --EE----------HHHHHHH-------------------HHHHH-----------------------HHHHH---------------------------------------------------------------------------HHHH-------------------------------------------------------------------------------------------EEEE---------------------- CPSF4_1 sable ---------------HHHHHHHH------------------------------------------EEE-HHH-----------------------HHHHHHH---------EEE---------------------------------------------------------------------------------------------------------------------------------EEE----------------------- CPSF4_1 proteus --HHHH-HHH---HHHHHHHHH---------------HHHHHHHH--------------E---EEEEEEE--E-EEE---EEEEE-----H----HHHHHH-----------------------HHH----------HHH--EE----------------------------------------------------------------------------EEEEEE--------------H-EEEEE------E--------HHH---- CPSF4_1 sspro4 --------------HHHHHHHHH---------------------------------------------HHHHH-----------------------EHHH------------------------HHHHH-------------------HHHHH--------------------------------------------------------------------------------------------E----------------------- CPSF4_1 psspred -HHHH---------HHHHHHHHH---------------HHHHHHHHH-------------------H-HHHHH---------------------------------------------------------------------------HHHHH------------------------------------------------------------------------------------------E-E-------E--------------- CPSF4_1 spineX ------------E-----E-------------------EEEEEE------------------------HHHH-----------E-----------EEEE-------------EE-----EEE------------------------E--------------------------------------------------------E---------------------------------------EEE----------------------- CPSF4_1 raptorxss -HHHH---------HHHHHHHH---------------------E------------E-----------HHHH----------------------------------------------------HHHH--------------------------------------------------------------------------------------------------------------------EE-------HH---------HH--- CPSF4_1 SPARROW ---------------HHHHHHH--------------------------------------------HHHHHHH-----------------------------------------------------H--------------------------------------------------------------------------------------------------------------------E-----------H------------- CPSF4_1 *SPARROW HHHHHHHHHHEEEEHHHHHHHHH-------------HHHHHHHHHH---------HHHH-----HEEHHHHHHHH-------EEE----H-H---EEEEE-----------HHH----H--------------------HHHHHHHH---E----------------------------------------------------------------------------------------HHHH--H--H----EEE------------- CPSF4_1 HMMSTR ---HEE--------HHHHHHHHH---------------HHHHHHH---------------------E-HHHH------HHH---E---------E-HHHHHH----E-----E------------------------------------HH-------------------------------------------------------------------------------------------EEEE-----------------EE---- CPSF4_1 porter --EEEEEHHH----HHHHHHHHH---------------EEEEHHHHHH-----------------EHHHHHHH---------------------HHHHHH------------------------------------------------HHH--------------------------------------------------------------------------------------------EEEE-------------HHHE----- CPSF4_1 spine HHHHHHH-------EEE----------------------HHHHHHH-------------------EEE---------------EE-----------EEE-------------EE------------------------------EEEEE-----------------------------------------------------EEEEE-------------EEEEE-----------------EEEE----------------EEEE--- CPSF4_1 nnssp --HHHHHHHHHHHHHHHHHHHHH-------------HHHHHHHHHHHH---------------EEEEEEEEEEEEEE---EEEEEE---------------------------------------------------------EEEEEEE----------------------------------------------------EEEEEE-----------EEEEEEE------------------------------------------- CPSF4_1 pssfinder HHHHHHH----EEEEEEEHHHH---------------EEEEEEEEE----------EEEE----EEE--EEE---------EEEEEE---------EEEEEE---------EEEE----------------------------EEEEEEEEE----------EE--------------------------------------EEEEEE-----------EEEEEEE----------------EEEEEE-------------EEEEEE-- CPSF4_1 sspal HHHHHHHHHHHHHHHHHHHHHHH---------HHHHHHHHHHHHHH------------------EEEEEEEEE------HHHHHHHHH-------EEEEEEE---------------------------------------EEEEEEEE-EEEEEEE--------------------------------------------------------------EEEEEEE----------------EEEE----------------------- CPSF4_1 ssp --------------HHHHHHH---------------------EHHH-----------------------HHHH------------------------EE-----------------------------------------------------------------------------------------------------------------------------------------------EEEEE---------------------- CPSF4_1 sspred ----------------HHHHHH--------------------------------------------HHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEEE----------------------- CPSF4_1 netsurfp --------------HHHHHHHHH------------------EEE----------------------E--HHH-------------------------HHH-------------------------HHH--------------------HHHH-------------------------------------------------------------------------------------------EE--------EE-------------- CPSF4_1 soprano --------------HHHHHHHHH------------------HHHH---------------------E-HHHH-------------------------EE------------------------------------------------------------------------------------------------------------------------------------------------EEE----------------------- CPSF4_1 consensus MAAAAAAAAAAGAAGGRGSGPGRRRHLVPGAGGEAGEGAPGGAGDYGNGLESEELEPEELLLEPEPEPEPEEEPPRPRAPPGAPGPGPGSGAPGSQEEEEEPGLVEGDPGDGAIEDPELEAIKARVREMEEEAEKLKELQNEVEKQMNMSPPPGNAGPVIMSIEEKMEADARSIYVGNVDYGATAEELEAHFHGCGSVNRVTILCDKFSGHPKGFAYIEFSDKESVRTSLALDESLFRGRQIKVIPKRTNRPGISTTDRGFPRARYRARTTNYNSSRSRFYSGFNSRPRGRVYRGRARATSWYSPY PABP-2_1 sequence -HHHHHHHHHH---------------------------------------------HHH---------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----------------HHHHH-----EEEEE-------HHHHHHHH-------EEEEE----------EEEEEE--HHHHHHHHH---------EEEEEE------------------------------------------------------------ PABP-2_1 psipred -HHHHHHHHHH--------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----------------HHHHH-----EEEEEEE-----HHHHHHHHH----EEEEEEEEE--------EEEEEE--HHHHHHHHH---------EEEEE------------------------------------------------------------- PABP-2_1 prof -----EEEEE-----------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHH---------------------------EEEEEE-----HHHHHHHHH-----EEEEEEE-----------EEEE---HHHHHHHHHH--HHHH--EEEEE------------------------------------------------------------- PABP-2_1 jnet -HHHHHHHHH-----------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------------------------EEEEE-------HHHHHHHHHH---EEEEEEEE---------EEEEEE--HHHHHHHHH---------EEEEE------------------------------------------------------------- PABP-2_1 sable -------------------------------------------HHHHHHHHHHHHHH---------------------------------------HHHHH--------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------------------------EEEEEE-------HHHHHHHHHH---EEEEEEEE---------EEEEEE--HHHHHHHHHHH------EEEEEE------------------------------------------------------------- PABP-2_1 proteus -HHHHHHHHHHHHH--------HHHH----------------HE-----HHHHH--HHH-------------------------------------EE------EE----------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------------HHHHHH----EEEEE-------HHHHHHHHH----EEEEEEEEE--------EEEEEE--HHHHHHHHHH--------EEEEE-----------------------EE--------HH-----------EE------------- PABP-2_1 sspro4 ------------------------------------------HHHHH----------HHHHH----------------------------------HHHH--HHH----------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----------------HHHH-----EEEEE-------HHHHHHHHHH---EEEEEEEE--------EEEEEEE--HHHHHHHHHH---EE--EEEEEEE------------------------------------------------------------ PABP-2_1 psspred HHHHHHHHHHHH--------------------------------------------HHHHHH---------------------------------HHHHHHHHHHH---------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------------HHHHHH----EEEE--------HHHHHHHHHH---E-EEEEEE---------EEEEEE--HHHHHHHHHH---E---EEEEE-------------------HH----------------------------------------- PABP-2_1 spineX --HHHHHHHHH-----------------------------------------------------------------------------------------------------------HHHHHHHHHHHH------------------------------------------EEEE--------HHHHHHHH-----EEEEEEEE----------EEEEE--HHHHHHHHHH---EE---EEEEE----------------------------------------------EEE------------ PABP-2_1 raptorxss ----HHHHHH----------------------------------HH-------------HH------------------------------------HHHHHHHH-----------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----------------HHHHH-----EEEEE-------HHHHHHHHHH---EEEEEEEEE--------EEEEEE--HHHHHHHHHH--------EEEEEE------------------------------------------------------------ PABP-2_1 SPARROW ------HHHH---------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------------------------EEEEE-------HHHHHHHHH----EEEEEEEE------EEEEEEEEE--HHHHHHHHHH---EE--EEEEEE------------------------------------------------------------- PABP-2_1 *SPARROW HHHHHHHHEEE-----------------------------------------------HHHHHHH------------------------------HHHHHHHHH-----------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------------HHHHHH--EEEEEEE-EE----HHHHHHHHHH---EEEEEEEE----------EEEEEEEHHHHHHHHHH-HHHE---EEEEEE------------------------------------------------------------ PABP-2_1 HMMSTR -HHHHHHHHHHHH-------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----------------HHHHHH-HHHEEEEE-------HHHHHHHHHHH--EEEEEEEE--------EEEEEEE---HHHHHHHHH---EE--EE-EEEE------------------------------------------------------------ PABP-2_1 porter --HHHHHHHHHHHH--------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------------HHHHH-----EEEEE-------HHHHHHHHHH---EEEEEEEE--------EEEEEEE--HHHHHHHHHH---EE--EEEEEE------------------------------------------------------------- PABP-2_1 spine HHHHHHHHHHH-----------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----------EEEHHHHHHHH---EEEEE-------HHHHHHHH--------EEEE-----------EEEE---------HHHHHHHH-----EEE-----------------------------------EE------------------------- PABP-2_1 nnssp --HHHHHHHHH------------EEEEEE---------------------------HHHHHH------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------------HHHHHHHHH-EEEE--------HHHHHHHH-------EEEEEEE--------EEEEEE--HHHHHHHHHHHHHHH---EEEEEE------------------------------------------------------------ PABP-2_1 pssfinder HHHHHHHHHHHH---------------------------------------------HHH--------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------------EEEEEHHH-------EEE--------HHHHHHHH-------EEEEE-----------EEEE---------HHHHHHH-----EEEEEEE------------------EEEEE-------HHH-------------------------- PABP-2_1 sspal HHHHHHHHHHH---------------------------------------HHHHHHHHHHHHH--------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----------HHHHHHHHHH--EEEEE------HHHHHHHHH--------EEEEEEE--------EEEEEEE----EEEEEEE-------EEEEEEE------------------------------------------------------------ PABP-2_1 ssp -----HHHHHH-----------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHH-------------------------------EEEEE-------HHHHHHHHHH---EEEEEEE---------EEEEEEE--HHHHHHHHHH---EE--EEEEEE------------------------------------------------------------- PABP-2_1 sspred ----HHEEEH------------------------------------------------HH---------HHHHH---------------------------HHHHHH--------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------------------------EEEEE-------HHHHHHHHHH---EEEEEEEE---------EEEEEE--HHHHHHHHHH--------EEEEE------------------------------------------------------------- PABP-2_1 netsurfp ----HHHHHHH----------------------------------------------HHHH-------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------------------------EEEEE-------HHHHHHHHHH----EEEEEEE---------EEEEEE--HHHHHHHHH---------EEEE-------------------------------------------------------------- PABP-2_1 soprano --HHHHHHHHH---------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------------HHHHH-----EEEEE-------HHHHHHHHHH---EEEEEEEE---------EEEEEE--HHHHHHHHHH--------EEEEE------------------------------------------------------------- PABP-2_1 consensus MSVVPPNRSQTGWPRGVTQFGNKYIQQTKPLTLERTINLYPLTNYTFGTKEPLYEKDSSVAARFQRMREEFDKIGMRRTVEGVLIVHEHRLPHVLLLQLGTTFFKLPGGELNPGEDEVEGLKRLMTEILGRQDGVLQDWVIDDCIGNWWRPNFEPPQYPYIPAHITKPKEHKKLFLVQLQEKALFAVPKNYKLVAAPLFELYDNAPGYGPIISSLPQLLSRFNFIYN CPSF5_1 sequence ------------------------------------EEEEE---EEEE---------HHHHHHHHHHHHHHHHH--EEEEEEEEEEEE----EEEEEEE--EEEEE----------HHHHHHHHHHHHH---------EEEEEEEEEEE--------------------EEEEEEEEEE---EEEEE----EEEEE--------------EEE----EEEEEEEEE- CPSF5_1 psipred -----------------------------------EEEEE-----EE------------HHHHHHHHHHHHHH----EEEEEEEEEE-----EEEEEE----EEE-----------HHHHHHHHHHHHH---------EEHHHHHHHH-----------------------EEEEEEEE---EEEEE----EEEEE-EE-----------HHHHHHHHH---EEE-- CPSF5_1 prof ------------------------------------EEEEE------E-----------HHHHHHHHHHHHHH----EEEEEEEEE-----EEEEEEE----EEEE-----------HHHHHHHHHHH----------EEEEEEEEEEEE--------------------EEEEEEEE-----EEE------EEEE-----------HHHHHHHHHHHHHHH----- CPSF5_1 jnet -----------------------------------EEEEE---EEEEE----------HHHHHHHHHHHHHHH----EEEEEEEEEE-----EEEEEE----EEEE---EE------HHHHHHHHHHH----------EEEEEEEEEEE---------------------EEEEEEEEE---EEEEE----EEEE---HH----------EHHHHHHHHHHEEEEEE CPSF5_1 sable ------------------------------HHHEEEEEEEE---EEEEEEEE-------HHHHHHHHHHHHHH--EEEEEEEEEEEEE--EEEEEEEEE---EEEEE--EEE----HHHHHHHHHHHHEEE-------EEE-EEEEEEEE----------EEE-----EEEEEEEEEE---EEEEEEE--EEEEEE-HHHH----------HHHHHHHHH-EEEEEE CPSF5_1 proteus -----------------------------------EEEE--------------------HHHHHHHHHHHHHH----EEEEEEEEEE-----EEEEEE----E-------------HHHHHHHHHHHHH-----------HHHHHHHHH--------------------HEEEEEEEE---H--EE-----EEEE--------------HHHHH-HHHHHHHEEE-- CPSF5_1 sspro4 -----------------------------------EEEEEE---EEEE----------HHHHHHHHHHHHHHHH--EEEEEEEEEEE-----EEEEEEE---EEEE---E------HHHHHHHHHHHHH---------EEEEEEEEEEE--------------------EEEEEEEEE----EEEEE----EEEEEEHHHHH-------HHHHHHHHHEEEEEEEE- CPSF5_1 psspred -----------------------------------EEEEEE----EE------------HHHHHHHHHHHHHHH----EEEEEEEEE----EEEEEEE----EEEE---E------HHHHHHHHHHHHH---------EEE-HHHHH-----------------------EEEEEEEE---EEEEEE----EEEEEE------------HHHHHHHHHHHHH-EEE- CPSF5_1 spineX -----------------------EEE---------EEEEEE-EEEEE-----------HHHHHHHHHHHHHHH---EEEEEEEEEE------EEEEEE---EEEEE---EE-----HHHHHHHHHHHH----------EEE-----EEE---------------------EEEEEEEE----EEEEE----EEEE---------------EE---HHHHH---EE-- CPSF5_1 raptorxss -----------------------------------EEEEEEEEEEEEE----------HHHHHHHHHHHHHHHH--EEEEEEEEEEEE---EEEEEEEE---EEEEE-EE------HHHHHHHHHHHHH----------EEEEEEEEEE--------------------EEEEEEEEEE---EEEE------EEEE---H------HH-HHHHHHHHHHEEEEEEE- CPSF5_1 SPARROW -----------------------------------EEEEE----EEE------------HHHHHHHHHHHHHHH--EEEEEEEEEEE-----EEEEEE----EEE----E------HHHHHHHHHHHHH---------EEE--EEEEEE----------------------EEEEEEE-----EEE-----EEEEE-HHHH--------HHHH-HHHHHHHEEEE-- CPSF5_1 *SPARROW --E--------------------------------EEEEEE----EE------HHHHHHHHHHHHHHHHHHHHH--EEEEEEEEEEE-----EEEEEEHHH-EEE-----EE--HHHHHHHHHHHHHHHH-------HHHHHHHHHHHE-------------------HHHHHEEEEE---H-EEE-----EEEEE-HHHHHHH-HHH--EEEE---EEEEEEEEEE CPSF5_1 HMMSTR -----------------------------------EEEE-EHHHEEEEEE---------HHHHHHHHHHHHHHH--EEEEEEEEEEEE--EEEEEEEEEE--EEE--EEE------HHHHHHHHHHHHH----------EEEEEEEEEEE-------E-----------EEEEEEEEE----EEEEEE---EEEEEEHHHH---HHHHHHHH--HHHHH---EEEE- CPSF5_1 porter --E---------------------E-------EEEEEEEE-----E-----------HHHHHHHHHHHHHHHHH---EEEEEEEEEE-----EEEEEE----EEE----E-----HHHHHHHHHHHHHH---------HHHHHHHHH---------------------HHHHHEEEEE--HHHEEE-----EEEEEEHHHH------H-HHHH-HHHHHHHHH---- CPSF5_1 spine -EE--------------------------------EE----------------------HHHHHHHHHHHHHHH-------EEEEE-------EEEEE-------------------HHHHHHHHHHHH--------------------------------------------EEEEEHHHHHHH-------HHHHHHHHHH-------------HHHHHH---EE- CPSF5_1 nnssp --------------------------------HHHHHHH--------------------HHHHHHHHHHHHHHH-------EEEEEE-----EEEEEE---EEEE-----------HHHHHHHHHHHHH------------------------------EEEEEEE--HHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHH-------------HHHHHHH------ CPSF5_1 pssfinder EEEE----------------------------HHHHHH-------------------HHHHHHHHHHHHHHHHH-------EEEEEE------EEEEE------------------HHHHHHHHHHHHH-----EE-------------------------------------EEHHHHHHHHHH------HHHHHHHHHH------------HHHHHH-----EEE CPSF5_1 sspal ------------------------------EEEEEEEE---EEEEEEE----HHHHHHHHHHHHHHHHH---------EEEEEEEEE-----EEEEEEEEEEEEEEE-----HHHHHHHHHHHHHHHHH-----EEEEEEE---------------------------HHHHHHHHHHHHHH--------EEEEEHHHHHHH------------HHHHHHHHHHHHH CPSF5_1 ssp ----------------------------------EEEEEEE--EEEEE-----------HHHHHHHHHHHHH-----EEEEEEEEEEE----EEEEEEE--EEEE------------HHHHHHHHHHHH----------EHHHHHH-E-----------------------EEEEEEEE--EEEEE-----EEEEEE-----------------HHHHHHEEEE--- CPSF5_1 sspred -----------------------------------EEEEE-----EE------------HHHHHHHHHHHHHH----EEEEEEEEEE-----EEEEEE----EEEE---E------HHHHHHHHHHHHH---------EEEE-EEEE-----------------------EEEEEEEE-----EEE------EEE--------------HHHHHHHHHHH-EEEE-- CPSF5_1 netsurfp -----------------------------------EEEEE----EEE------------HHHHHHHHHHHHHHH---EEEEEEEEEE-----EEEEEE----EEEE---EE------HHHHHHHHHHHH----------EEEEEEEEEE---------------------EEEEEEEEE----EEEE----EEEE---------------EEE----EE-EEE-E-- CPSF5_1 soprano -----------------------------------EEEEE----EEE------------HHHHHHHHHHHHHHH---EEEEEEEEEE-----EEEEEE----EEEE---E------HHHHHHHHHHHHH---------EEEEEEEEEEE---------------------EEEEEEEE----EEEE-----EEEEE--HH----------HHH-HHHHHHHEEEE-- CPSF5_1 consensus MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV PABP-1_2 sequence -----------EEEE--------HHHHHHHH-----EEEEEEEE---------EEEEEE--HHHHHHHHHH----EE----EEEE---------------EEE--------HHHHHHHHH----EEEEEEEE------EEEEEEE--HHHHHHHHHHH--------EEEEEE-----HHHHHHH-------------------HHHHHHHHH------EEEEEE---------EEE----HHHHHHHHHHH-------EEEEEE-----HHHHHHHHHHHHHHHHHHH------EEE---------HHHHHHHH-----EEEEEEEEE---EEEEEEEE---HHHHHHHHHHH--EEE--EEEEEE-----HHHHHHHHHHHHHHHH----------------------------------------------------------------------HHHH----HHHHHHHHHHHHHHHHHH-----------------HHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHH---------- PABP-1_2 psipred -----------EEEE------HHHHHHHHHHH----EEEEEEE----------EEEEE---HHHHHHHHHHH---------EEEEEE-------------EEEE--------HHHHHHHHHH--EEEEEEEE-------EEEEE--HHHHHHHHHHHHH-------EEEEE-----HHHHHHHHHHHHHH--EEEE-------HHHHHHHHHH---EEEEEEEEE-------EEEEE---HHHHHHHHHHH--------EEEEE-HHHHHHHHHHHHHHHHHHHHHHHHHH---EEEEE-------HHHHHHHH-----EEEEEEEE-------EEEEEE--HHHHHHHHHHHHHHH-----EEEEEHHHHHHHHHHHHHHHHHHHHH---------------------------------------------------------------------HHHHH---HHHHHHHHHHHHHHHHHHH-HHH--HHHHHHHH--HHHHHHH---HHHHHHHHHHHHHHHHHHHHH---------------- PABP-1_2 prof ------------EEE--------HHHHHHHH-----EEEEEEE-------------------HHHHHHHHHH---------EEEEE------------EEEEEE-----------HHHH-------EEEEEE------EEEEEEE-HHHHHHHHHHHH---E----EEEE---------------------EEEEE------HHHHHHHHH-----EEEEEEEE-------EEEEEE---HHHHHHHHHHH--------EEEEE----HHHHHHHHHHHHHHHHHHHH-------EEEE-------HHHHHHHH------EEEEEEE-------EEEEEE---HHHHHHHHHHHHHHHH---EEEE----HHHHHHHHHHHHHHH-----------------------------------------------------------------------HHHHH----HHHHHHHHHHHHHHHHHHH------------------EEEEEE---HHHHHHHHHHHHHHHHHHH----------------- PABP-1_2 jnet -----------EEEE--------HHHHHHHHHH---EEEEEEE----------EEEEE---HHHHHHHHHH---------EEEEEE-------------EEEEE-------HHHHHHHHHH---EEEEEEEE-------EEEEEE--HHHHHHHHHHH---E----EEEEEE-------------------EEEEE-------HHHHHHHHHH---EEEEEEEE--------EEEEEE--HHHHHHHHHHH--------EEEEEE-----------------------------EEEEE-------HHHHHHHHH----EEEEEEE--------EEEEE---HHHHHHHHHH----EE---EEEEEE-------------------------------------------------------------------------------------------------------------------------------HH----HHHHHHHH--HHHHHHHHHHHHHHHHHH------------------H PABP-1_2 sable -----------EEEEE-------HHHHHHHHHHH-EEEEEEE-EE--------EEEEEE--HHHHHHHHHHH-------EEEEEEE------------EEEEEE-------HHHHHHHHHHHEEEEEEEEE-E-E----EEEEEE--HHHHHHHHHHH----------EEEE------------------EEEEEE-------HHHHHHHHHHH-EEEEEEEEE----EEE-EEEEEEE-HHHHHHHHHHH---------EEEEEE------HHHHHEE---------------EEEEE-------HHHHHHHHHHH--EEEEEEE--------EEEEEEE-HHHHHHHHH---------EEEEEEEE-------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHH----HHHHHHHHH-----HHHHH---HHHHHHHHHHHHHHHHHHH------------------ PABP-1_2 proteus ----------EEEEE--------HHHHHHHHHHH--EEEEEEEE---------EEEEE---HHHHHHHHHHH--EEE--EEEEEEE-------------EEEE--------HHHHHHHHHHH--EEEEEEEE------EEEEEEE--HHHHHHHHHHH--EEE--EEEEEE-----HHHHHHH--------EEE---------HHHHHHHHHH---EEEEEEEE-------EEEEEE---HHHHHHHHHHH--EEE--EEEEEE----HHHHHHHHHHHHHHHH----------EEEE--------HHHHHHHHHH---EEEEEEE-------EEEEEE---HHHHHHHHHHH--EEE--EEEEEEE---HHHHHHHHHHHHHHH---------------------------------------------------------------------------------HHH-------------------------------HHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHH----------- PABP-1_2 psspred ----------EEEEE--------HHHHHHHHHHH----EEEEEE---------EEEEE---HHHHHHHHHHH---E---EEEEEEEE------------EEEE--------HHHHHHHHHHH--E-EEEEEEE------EEEEEE--HHHHHHHHHHHH--E----EEEEE-----HHHHHHHHHHHH---EEEE--------HHHHHHHHHHH--E-EEEEEE--------EEEEE---HHHHHHHHHHH--EEE--EEEEEE----HHHHHHHHHHHHHHHHHH-HH----EEEEE--------HHHHHHHHHHH--E-EEEEEE-------EEEE----HHHHHHHHHHH--EEE---EEEEE----HHHHHHHHHHHHHHHHHHH-----------------------------------------------------------------------------HH------------------HH-------HH---HHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHH---------- PABP-1_2 spineX ----------EEEEE--------HHHHHHHH-----EEEEEE-----------EEEEEE--HHHHHHHHHH---------EEEEEE-------------EEEE--------HHHHHHHHHH---EEE-EEEE-------EEEEEE--HHHHHHHHHHH---E----EEEEEEE------------------EEEE--------HHHHHHHH-----EEEEEEE---------EEEEEE--HHHHHHHHHH---EEE--EEEEEE------------------------------EEEE--------HHHHHHH------E-EEEEEE-------EEEEE---HHHHHHHHHH---EEE---EEEEEE---------------H-------------------------------------------------------------------------------------------------------HH-------HH---HHHHHHHH--HHHHHHHHHHHHHHHHHHH------------------ PABP-1_2 raptorxss -----------EEEEE-------HHHHHHHHH-H--EEEEEEEE---------EEEEEE--HHHHHHHHHHH---EE---EEEEEH------------EEEEEE-------HHHHHHHHHH---EEEEEEEEE----EEEEEEEE--HHHHHHHHHHH---EE--EEEEEEE------------------EEEEEE-------HHHHHHHHHH---EEEEEEEE-------EEEEEEE--HHHHHHHHHHH---EE--EEEEEE-------HHHHHHHHHHHH-----------EEEEE-------HHHHHHHHH----EEEEEEEE-------EEEEEE--HHHHHHHHHH----EE--EEEEEE-----HHHHHH---HHH-------------------------------------------------------------------------------------------HHH----H-H--HH------------HHHHHHHH--HHHHHHHHHHHHHHHHHHHH--HH------------- PABP-1_2 SPARROW ------------EEEE-------HHHHHHHHH----EEEEEEE----------EEEEEE--HHHHHHHHHHH---EE---EEEEEEEE------------EEEE-------HHHHHHHHH----EEEEEEEE-----E-EEEEE---HHHHHHHHHHH---EE---EEEEEE-------------------EEEEE-------HHHHHHHHHHH--EEEEEEEE--------EEE-----HHHHHHHHHHH--EEE--EEEEEEE------HHHHH------------------EEEEE-------HHHHHHHHHH---EEEEEEEE-------EEEE----HHHHHHHHHHH---EE---EEEEE-----------------------------------------------------------------------------------------------------------------------HHH------------HHHHHHHH--HHHHHHHHHHHHHHHHHHHH----------------- PABP-1_2 *SPARROW ---------EEEEEEEE------HHHHHHHHHHH--EEEEEEEE------EE--EEEEEE-HHHHHHHHHHH--EEE----EEEEEEE--HHHHH---EEEEEE-HHHHH-HHHHHHHHHHHEEEEEEEEEE------EEEEEEEEEHHHHHHHHHHE---EE---EEEE-----HHHHHHHHHHHHHHHHHEEEE-------HHHHHHHHHHH-EEEEEEEEE-----EE---EEEEE-HHHHHHHHHHH---EE---EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH---EEEEE-------HHHHHHHHHHHEEEEEEEEEEH-------EEEEEE-HHHHHHHHHHH---EEEE---HHHHHHHHHHHHHHHHHHHHHHHHHH-------------------------------------------------------------------HHHHHHH--HHHHHHHHHHHHHHHHHHH-HHHH--EE--EEEE-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------HH-HHH PABP-1_2 HMMSTR -----------EEEEE-------HHHHHHHHHHH--EEEEEEEE------EEEEEEEEE--HHHHHHHHHHH---EE--EE-EEEE-----HHHH----EEEEE-------HHHHHHHHH----EEEEEE----------EEEEE--HHHHHHHHHH----EE--EEEEEEE-------------------EEEEE-------HHHHHHHHH----EEEEEEEE-----EEEEEEEEE--HHHHHHHHHHH---EE--EEEEEEE-----------------------------EEEEE-------HHHHHHHHH----EEEEEEEE-----EEEEEEEE--HHHHHHHHHHH---E----EEEEEE------------HHH---------------------------------------------------------------------------HHHH----------HHHHHHHHHHHHH-HHHHHHHHHHH----HHHHHHHH--HHHHHHHHHHHHHHHHH-------------------- PABP-1_2 porter -----------EEEE--------HHHHHHHH------EEEEEEE---------EEEEEE--HHHHHHHHHHH---------EEEEE-------------EEEE--------HHHHHHHHH-----EEEEEEE-------EEEEEE--HHHHHHHHHHH---------EEEEE------------------EEEEE--------HHHHHHHH-----EEEEEEEE--------EEEEEE--HHHHHHHHHHH---------EEEEE--------HHHHHHH-------------EEEEEE-------HHHHHHHH-----EEEEEEEE--------EEEEE--HHHHHHHHHHH---------EEEEE--------HHHHHHHH----------------------------------------------------------------------------------------------------------------------HHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHH--------- PABP-1_2 cdm -----------EEEEE-------HHHHHHHHHHH--EEEEEEEE------EEEEEEEEE--HHHHHHHHHH----EE--EE-EEEE-------------EEEEE-------HHHHHHHH-----EEEEEEE--------EEEEEE--HHHHHHHHHHH---EE--EE-EEEE-------------------EEEEE-------HHHHHHHHH----EEEEEEEE-----EEEEEEEEE--HHHHHHHHHHH---EE--EE-EEEE---------HHHHHH-------------EEEEEE-------HHHHHHHH-----EEEEEEEE--------EEEEE--HHHHHHHHHHH---------EEEEE--------HHHHHHHH--------------------------------------------------------------------------HHHHH---HHHHHHHHHHHHHHHHHHH----HHHHHHHH----HHHHHHHHH-HHHHHHHHHHHHHHHHH-------------------- PABP-1_2 fdm -----------EEEEE-------HHHHHHHHHHH--EEEEEEEE------EEEEEEEEE--HHHHHHHHHH----EE--EE-EEEE-------------EEEEE-------HHHHHHHH-----EEEEEEE--------EEEEEE--HHHHHHHHHHH---EE--EE-EEEE-------------------EEEEE-------HHHHHHHHH----EEEEEEEE-----EEEEEEEEE--HHHHHHHHHHH---EE--EE-EEEE-----------------------------EEEEE-------HHHHHHHHH----EEEEEEE--------EEEEEE--HHHHHHHHHHH---EE--EE-EEEE------------HHHHHHHHHHH-------------------------------------------------------------------HHHHH---HHHHHHHHHHHHHHHHHHH----HHHHHHHH----HHHHHHHHH-HHHHHHHHHHHHHHHHH-------------------- PABP-1_2 gor -----------EEEEE-------HHHHHHHHHH---EEEEEEEE---------EEEEEE--HHHHHHHHHHH---EE---EEEEEE-------------EEEEE-------HHHHHHHHHHH--EEEEEEEE------EEEEEEE--HHHHHHHHHHH--EEE---EEEEE------HHHHHHHHHH----EEEEE-------HHHHHHHHHH---EEEEEEEE------EEEEEEEE--HHHHHHHHHHH--EEE--EEEEEE------HHHHHHHHHHHHHHH---------EEEE--------HHHHHHHH-----EEEEEEE-------EEEEEE---HHHHHHHHHHH--EEE----EEEEE----HHHHHHHHHHHHHHHHH------------------------------------------------------------------------------HHHHHH-HHH-HHHHHH----HHHHHHHHHHH--HHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHH--------- PABP-1_2 spine ------------EE--------HHHHHHHH------EEEEHHHHHHHHH----EEEE------HHHHHHHHH---------EEEEE--------------EEE---------HHHHHHHHHH-----EEEEE---------EEE---HHHHHHHHHHHHHHH-----EEEE-----HHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHH------EEEE----------EEEE---HHHHHHHHHHH--------EEEEEHHHHHHHHHHHHHHHHHHHHH----------EEE--------HHHHHHHH-------HHHHHHH-------EEEEE--HHHHHHHHHHH---EEE---HHHHHHHHHHHHHHHHHHHHHHHHHHH-------------------EEE------------------------------------EE-----------------HHHHHHHHHHHHHHHHHH----------EEEE---HHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHH------E PABP-1_2 nnssp -----------EEEEE-------HHHHHHHHHHH--EEEEEEEE------EEEEEEEEE--HHHHHHHH-------------EEEE-----HHHH----EEEEE-------HHHHHHHHHHH--EEEEEE----------EEEEE--HHHHHHH-----EEEE--EEEEEEE---HHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHH--EEEEEEEE---------EEEEE--HHHHHHHHHHH--------EEEE-HHHHHHHHHHHHHHHHHHHHHHHHHHH---EEEEE-------HHHHHHHH--------HHHHHH------EEEEEE--HHHHHHHHHHH--EEEEE--HHHHHHHHHHHHHHHHHHHHHHHHHHHH----------------------------------HHHHHHH--------------------------HHHHH---HHH---------HHHHHHH----HHHHHHHHHH--HHHHHHHHH-HHHHHHHHHHHHHHHHHH-HHHH-------------- PABP-1_2 pssfinder -----------EEEE------HHHHHHHHH---------HHHHHHHHH-----EEEEE------HHHHHHHHHHHHH----EEEEEE-----HHH-----EEHHHH-----HHHHHHHHHHHH----EEEEE---------EEE---HHHHHHHHHHHHHHH-----EE-------HHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHH------EEEEE----------EEEHHHHHHHHHHHHHH--------EEEHHHHHHHHHHHHHHHHHHHHHHHH--------EEEE--------HHHHHHHH----EE--HHHHHH------EEEEEE--HHHHHHHHHHH---EEEE--HHHHHHHHHHHHHHHHHHHHHHHHHHHH------------------EEE----HHHHHH-----HHHHH----------------EEE-----HHHHHH----HHHHHHHHHHHHHHHHHHH-HHHH-HHHHHHH----HHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------- PABP-1_2 sspal ------------EEEE------HHHHHHHHH-----EEEEEEEHHHHHHHHH-------HHHHHHHHHHH-----------EEEE----------------HHHHHHHHHHHHHHHHHHHHH--EEEEEEEE-------EEEEEHHHHHHHHHHHHHH--------EEEEHHHHHHHHHHHHHHHHHHHHHHEEEE-HHHHHHHHHHHHHH------EEEEEEE--------EEEHHHHHHHHHHHHHHHH--------EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEE------HHHHHHHHH--------------------EEEEEEE--HHHHHHHHHH------HHHHHHHHHHHHHHHHH---HHHHHHHHH--------------------------HHHHHHHHH---HHHHHH---------------EEEE----HHHHHHHHH--HHHHHHHHHHH--HHHHH---HHHHHHHHHHH---HHHHHHHHH-HHHHHHHHHHHHHHHH-HHHHHHHHH---------- PABP-1_2 ssp -----------EEEEE-------HHHHHHHHHH---EEEEEEEEE--------EEEEEE--HHHHHHHHHHH--------EEEEE--------------EEEEE-------HHHHHHHHHH---EEEEEEEEE-----EEEEEEE--HHHHHHHHHHH---EE---EEEEEE-------------------EEEEE-------HHHHHHHHHH---EEEEEEEE-------EEEEEEE--HHHHHHHHHHH--------EEEEEE----------HHH----------------EEEEE-------HHHHHHHHHH---EEEEEEE--------EEEEEE--HHHHHHHHHHH--------EEEEEE---------------------------------------------------------------------------------------------------------------HHHH---------HHHHHH---HHHHHHH---HHHHHHHHHHHHHHHHHHH------------------ PABP-1_2 sspred -----------EEEEE-------HHHHHHHHHH---EEEEEEEE---------EEEEEE--HHHHHHHHHHH--------EEEEE--------------EEEEE-------HHHHHHHHHH----EEEEEEE-------EEEEEE--HHHHHHHHHHH---E----EEEEEE-------------------EEEEE-------HHHHHHHHHH---EEEEEEEE-------EEEEEEE--HHHHHHHHHHH---EE---EEEEEE-------HHHHHHH---------------EEEE--------HHHHHHHHHH---EEEEEEEE------EEEEEE---HHHHHHHHHHH---EE--EEEEEEE-------------------------------------------------------------------------------------------------------------------------------------HHHHHHHH--HHHHHHHHHHHHHHHHHHHH----------------- PABP-1_2 netsurfp -----------EEEE--------HHHHHHHHH----EEEEEE------------EEEE---HHHHHHHHHHH---EE---EEEEEE-------------EEEE--------HHHHHHHHHH----E-EEEEE--------EEEEE--HHHHHHHHHHH---EE---EEEEEE-------------------EEEE--------HHHHHHHHH----EEEEEEEE--------EEEEEE---HHHHHHHHHH---EE---EEEE---------HHHHHHHH-HH-----------EEEE--------HHHHHHHHH----EEEEEEE--------EEEEE---HH-HHHHHHH----EE---EEEEEE--------HHH-HHHHH---------------------------------------------------------------------------------------------------------------------HHHHHHH--HHHHHHHHHHHHHHHHHHHH----HHH---------- PABP-1_2 soprano -----------EEEEE-------HHHHHHHHHH---EEEEEEEE---------EEEEEE--HHHHHHHHHHH---E----EEEEEE-------------EEEEE-------HHHHHHHHHH---EEEEEEEE-------EEEEEE--HHHHHHHHHHH---E----EEEEEE-------------------EEEEE-------HHHHHHHHHH---EEEEEEEE--------EEEEEE--HHHHHHHHHHH---EE---EEEEEE------HHHHHHHHHHHH-----------EEEEE-------HHHHHHHHH----EEEEEEEE-------EEEEEE--HHHHHHHHHHH---EE---EEEEEE----HHHHHHHHHHHHHH---------------------------------------------------------------------------------HHH--H-HHHHHHHHHHH----------HH----HHHHHHHH--HHHHHHHHHHHHHHHHHHHH----------------- PABP-1_2 consensus QETTNQHSTKSGTEPKENVENWQSSKSAKRWKSGWEENKSLQQVDEHSKPPHLRHRESWSSTKGILSPRAPKQQQHRLSVDANLQIPKELTLASKRELLQKTSERLASGEITQDDFLVVVHQIRQLFQYQEGVREEQRSPFNDRFPLKRPRYEDSDKPFVDSPASRFAGLDTNQRLTALAEDRPLFDGPSRPSVARDGPTKMIFEGPNKLSPRIDGPPTPASLRFDGSPGQMGGGGPLRFEGPQGQLGGGCPLRFEGPPGPVGTPLRFEGPIGQAGGGGFRFEGSPGLRFEGSPGGLRFEGPGGQPVGGLRFEGHRGQPVGGLRFEGPHGQPVGGLRFDNPRGQPVGGLRFEGGHGPSGAAIRFDGPHGQPGGGIRFEGPLLQQGVGMRFEGPHGQSVAGLRFEGQHNQLGGNLRFEGPHGQPGVGIRFEGPLVQQGGGMRFEGPSVPGGGLRIEGPLGQGGPRFEGCHALRFDGQPGQPSLLPRFDGLHGQPGPRFERTPGQPGPQRFDGPPGQQVQPRFDGVPQRFDGPQHQQASRFDIPLGLQGTRFDNHPSQRLESVSFNQTGPYNDPPGNAFNAPSQGLQFQRHEQIFDSPQGPNFNGPHGPGNQSFSNPLNRASGHYFDEKNLQSSQFGNFGNIPAPMTVGNIQASQQVLSGVAQPVAFGQGQQFLPVHPQNPGFVQNPSGALPKAYPDNHLSQVDVNELFSKLLKTGILKLSQTDSATTQVSEVTAQPPPEEEEDQNEDQDVPDLTNFTVEELKQRYDSVINRLYTGIQCYSCGMRFTTSQTDVYADHLDWHYRQNRTEKDVSRKVTHRRWYYSLTDWIEFEEIADLEERAKSQFFEKVHEEVVLKTQEAAKEKEFQSVPAGPAGAVESCEICQEQFEQYWDEEEEEWHLKNAIRVDGKIYHPSCYEDYQNTSSFDCTPSPSKTPVENPLNIMLNIVKNELQEPCDSPKVKEERIDTPPACTEESIATPSEIKTENDTVESV PCF11_1C sequence --------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHH--------------------------------------HH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHH--------------------------------------------HHHHHHHHHHHHHHH----------------HHHHHHHHHHHHHHH------------------------------HHHHHHH--HHHHHHHHHHHHHHHHHH----EE---------------------EE-----EEEE---EE---EEE----HHHHH--------------------HHHHHHHH-------------------------------------------- PCF11_1C psipred ----------------------------------------------------------------------------------------------HHHHHHHHHH--------HHHHHHHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHH----EEE---EE-----HHHHHHH-HHHH------------EE-EEEEEE---EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----EEE-----------HHHHHHHHH--HHHHHHHHHHHHH----------HHH----------------------HHH-EEE---------------------------------------------- PCF11_1C prof -------------------------------------------------------------------------------------HHHH-----HHHHHHHHHHH-------HHHHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHH-----------------HHHHHHH---------------EEEEE--EEEEE---HHHHHHHHHHHH------EEEE----EE-----------EEEE-------------------E----HHHHHH---EE-----E--EEEE-------E-------------------------------------------------------EEEE-------- PCF11_1C jnet --------------------------------------------------------------------------------------HHHHHH--HHHHHHHHHHHHH-------HHHHHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHH--------------------------------------------HHHH-HHHHHHHHHHH---------------HHHHHHHH--HHHHH--------------HEE--HHHHHH--------------------HHHHH-HHH--------E-------------E----HHHH-------EEE---EE----EEEE--HHHH------------------------------------------------------------------------- PCF11_1C sable -------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHH-----------------------------------HHHHHHHHHH----------------HHHHH---------------HHHHHHHHHHHHHHHHHHHHHHH-------EE-----HHH--------------------HHHHHHHHHHHH-----EE-----------------------------EEE---EE---EEEE-------------------------------------------------------------------------------- PCF11_1C proteus ------------------HHH-------------------------------------------------------EEE--------HHHHHH-HHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHH-HHHHH-------------------------HHHHH---------------------------------EE---------------------------------------------------------------EEE---------------------------------------------------------------------------------------------EEE-----------------------EEE------EE---------------EE-----------EEEE--------------------------------------EEEEE----------------------------------------------------------------H---------------------------------------------EEE----E-----------------------HHHHH---HHHHHHH-HHH---------------------------------------------------------------------HHHHHHHHHH--------------------------------------------HHHH-H-HHHHHHHHH---------------HHHHHHHHHHHHHHHH--------------EE--HHHHHHHHH------------------HHHHH-HHH-----EEE----HHHH----------HHHH--H-HHHHEHH-EEEE---EEE---HHHH--------------------HHHHHHE---------------EE------------------EE-----E--- PCF11_1C sspro4 -----------------------------------------------------------------------------------------------HHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHH----------------------------------------------HHHHH---HHHHHHHH---------------HHHHHHHHHHHHHHHHHH------------E---HHHHHHH------------------------------------E------------------HHHH-------EEE---EEE--EEE---HHHHHHH-------------------------HHH------------------------------------------- PCF11_1C psspred ----------------------------------HHHH-------------------------------------------------HHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHH-------------------------------------------HHHHHH--HHHHHHHH----------------HHHHHHHH-HHHHHH-----H------------HHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHH---E--------------H--HHH---------EEE---EEE--EEE----HHHHHH-------------------HHHHHHHHHH------------------------------E----------- PCF11_1C spineX -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HH---------------H-HHHHHHHHHH-----EEHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHH-------------HHHHHHHHHHHHHHH--HHHHH------EE----E-----HHH--------------------HHHHHHHHHHHH------------------------------------------ PCF11_1C raptorxss ---------------HHH-----------HH-----------------------H----------------------HHH-----------HHHHHHHHHHHHHHHH------HHHHHHHHHH--HHHHHHHHH-----------------------------HHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------E------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHH-----------------------------H--------------HHHH----HHHHHHH----------------HHHHHHHHH-HHHHHHHHHHHHHH----------HHH---------------------------HHHHHHH------E----------E--------H---------EEEEE-EEE--EEE-HHHHHHHH-------------------------HHHHHH---------------------HH------------------ PCF11_1C SPARROW -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHH-------------HHHHHHHHHHHHHHHHH------HHHHHHHH-HE-----HH-HHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------------------HHHHHHHHHHH--HHHHHHHH---EEE---EE----------------------------HHHHHHHHH-------------------------------------------- PCF11_1C *SPARROW ---------------HHHHHH---------E------------------------------------------H--EEE------------HHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHH---HHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HH-HHHHHHHHHHHHHHHH-----H--HEEEEEE-HHHHHHHHHHHHHH---HHHHHHHH--HH-EEE-HHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------HHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHE---EE-----H----------------------HHHHHHHHHHHH-------H--HH---------HHHHH--HHHH-----HHHH PCF11_1C HMMSTR ------------------HHHH--------------------H-----------------------------H--------------HHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHH---------------------------------------------HHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHH---------------------------HH---------------HHHHHHHHHHHHHHHH-----------------HHHHHHHHHHHHH-------------------HHHHHHHHHHHHHHHHH--------HHHHHHHHHHHHHHHHH-------------HHHHHHHHHHHHHHHHHHHHHH-------------------------------------HHHHHHHHHHHHH----------------------------------------- PCF11_1C porter ----------------------HHH----------------------------------------------HHHHHHH---------HHH--H-HHHHHHHHHHHH-----------HHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHH---------------------------HHHH-------------HHHH---HHHHHHHHH------E----------HHHHHH----------------------E---HHHHHHHHHHH-HHHHHH---HHHHHHHHHHHHHHHHH----EE--------------HH-HHHHHE---HHHEEEE-EEEE---EE-EEEEE---------------------HHHHHH----------------EEE-----------------EEE--------- PCF11_1C spine ----------------------------------------------------------------------------------------------HHHHHHHHHHHHH---------EEEHHHHHHHHHH------------------------------------------------------------------------EEE------------------EE--------------------------------------------------------------------------------------EE------------------------------------------------EEEE--------------------------------------------------------------EEE-----------------------EE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHH---EEE-------EEEEEE-------------------------HHHHHHHHHHHHHHH-----------EE--------------------------------EEEE-------HHHHHHHHHHH-HHHHHHHHHHHHHHHHHH--------------------HHHHHHHHHHHHHH--------EEE------------------------------------HHHHH------------------------------------------EEEE PCF11_1C nnssp ----------------------------------------HHHHHH-----------------------------------------HHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHH------------------------HHHHH----HHHHHHHHHH-------------------EEEE--------------------------------------------------------------------------------------------EEEE----------------------EEEE---------------------EEEEE--------EEEEE--------EEEEEEEEEEEEEEEEEE-----EEEEEEE----------EEEE--------EEEEEEEEEEE---EEEE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHH----------------------------------------------HHHHHHHHHHH-EEEEEE------------------------------------HHHHHHH--EEEEEEEEEEEE----------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------------HHHHHHHHHHH--HHHHHHHHHHH-----------------------------------HHHHHHHHHHHH------------------------------------------ PCF11_1C pssfinder --------------------------------------HHH-HHH------------------EE----------EEEEE---EEE--HHHHHHHHHHHHHHHHHH----------EEEEHHHHHHH-HHH---HHH--------------------------------------HHHH---------------------EEEE---------------------------------------------------------------------------EE----------------------------EEEEE--------EEEE----------------------------------EEEE-----------EEE---------EEEEE-----EEEEEEE--------------------EEEEEE---------------------EEEE--------------------------------------------------------------------------------------------------------------------------------EEEEE------------------------------------------------------------HHHHHHHHHHH-------------------------------------------HHHHHHHHHH--EEEEE-------EE----------------------------HHHHHHHHHHHHHHHEE------EEEEEEEEE-------EEEEEEE---------------EEEEE------HHHH-HHHH--HHHHHHH-HHHHHHHHH-------------------EEEEE------------EEEE------------------------------------------EEEEEE-----------------------------------------EEEE PCF11_1C sspal -----------------------------------HHHHHHHHH---------------------------------EEEE--------HHHHHHHHHHH------------HHHHHHHHHHHHHHHH-----------------------------------------HHHHHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHH---------------------------------------------------------------------------------------EEEE-------------------HHHHHHHHH---------------------------------------------------EEEE--HHHHHHHHHHHH-------------------EEEE-------------HHHHHHHHHHHHHHH--EEEE-------------------HHHHHHHHHH-------EEEEHHHHHHHHHHHHEEEEEEEE-----------HHHHHHHHHH---------EEEEEEE-EEEEEEE-HHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHHH--HHHHHHHHH-------EEEE---------EEEEEEE-----------HHHHHHHHHHHHHH--------------------------------------- PCF11_1C ssp -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHH-HHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PCF11_1C sspred ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHH------------HHHH-----EEEE---------------------HHHHH---HHHHHHH-------EE-----------------HHHH---HHHHHHHH---E-----------HHHH----------------------HH-HHH------------EEEE-------------------E--------- PCF11_1C netsurfp ----------------------------------------------------------------------------E----------HHH-HHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHH--------------------------------------------HHH----HHHHHHHH-----------------HHHHHHHHHHHHHHH-H---------------HHHHH-HH--------------HHH-HH-----HHH-------E------------------H--EE------EEE--EEE----EE---HHHHHHH----------------------------------------------------------------------- PCF11_1C soprano ----------------------------------------------------------------------------------------HH-HH-HHHHHHHHHHHH-------HHHHHHHHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHH--------------------------------------------HHHHHH-HHHHHHHHH----------------HHHHHHHH-HHHHH---------------EE----HHH-HHHHH-HHHHH---HHHHHHHHHHHHHHHHH------E-----------------HHHHH----HHH-EH---EE----EE----HH-----------------------HHHHHHH--------------------------------------------- PCF11_1C consensus MPFPVTTQGPPQPAPPPNRYGVSSPISLAVPKETDCLLTQRLIETLRPFGVFEEEEELQRRILVLEKLNNLVKEWIREISESKSLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVAPSHVDRSDFFTSFYAKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPEDLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKCHNIYSNILGFLGGVSWAMLVARTCQLYPNAVASTLVRKFFLVFSEWEWPNPVLLKEPEERNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSISTRMVMIEEFKQGLAITHEILLSKAEWSKLFEAPSFFQKYKHYIVLLASASTEKQHLEWVGLVESKIRILVGSLEKNEFITLAHVNPQSFPAPKENPDMEEFRTMWVIGLGLKKPDNSEILSIDLTYDIQSFTDTVYRQAVNSKMFEMGMKITAMHLRRKELHQLLPHHVLQDKKAHSTEGRRLTDLNDSSFDLSAGCENSMSVPSSTSTMKTGPLISSSQGRNSPALAVMTASVANIQATEFSLQQVNTNESSGVALNESIPHAVSQPAISPSPKAMVARVVSSTCLISHPDLQETQQQTYLIL PAPOLB_1 sequence --------------------------------HHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHH-------------EEEEE-------------EEEEEE------HHHHHHHHHHHH--------EEE-------EEEEEE--EEEEEEEEE--------------HHHH----HHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHH------------HHHHHHHHHHHHHH-----HHHHHHHHHHHHH-------EEE--------------------------EEE--------------HHHHHHHHHHHHHHHHHHHHHH-----HHHH-----HHHH---EEEEEEEE--HHHHHHHHHHHHHHHHHHHHHHH--------------------------EEEEEEEEEE--------------HHHHHHHHHHHHHHHH---------EEEEEEEE-HHHH---------------------------------------------------------------------------------------------------------------------------------------------- PAPOLB_1 psipred --------------------------------HHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHH---EEEEE--EEE----------EEEE-------HHHHHHHHHHHHH----------------EEEEEE---EEHHHHHHHHHH----------HHHHH---HHHHHH------HHHHHHH---HHHHHHHHHHHHHHHHH---HHH----HHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHH-------EE-----------EEE--------------EE--------------HHHHHHHHHHHHHHHHHHHHHHH----HHHHH---HHHHHHHHEEEEEEE----HHHHHHH--HHHHHHHHHHHHH----EEEE------------------EEEEEEEEEEEE--------EEE----HHHHHHHHHHHHHHHHH-----EEEEEEE---------------------------------------------------------------------------------------------------------------------------------------------------- PAPOLB_1 prof ------------------EEEE----------HHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHH-----EEE---EE--E------EEEEEE---------HHHHHHHHH----------------EEEEEEE-----HHHH----------------HHHHH-------EEE----HHHHHHHH----------HHHHHHHHHH-------EE-----HHHHHHHHHHHHH-------HHHHHHHHHH--------EEE-------------------------------------------HHHHHHHHHHHHHHHHHHHHHHH-------------------EEEEEEE----HHHHHHHHHHHHHHHHHHH---------EEEEE----------------EEEEEEEEEEE---------EEEE---HHHHHHHHHH------------EEEEEE--------------------------------------------------------------------------------------------------------------------------------------------------E-- PAPOLB_1 jnet --------------------------------HHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHH-------------EEEEE-------------EEEEEEE-----HHHHHHHHHHHHH-----EEEEEE----EEEEEEEE---EEEEEEEEE---------------HH-----HHH-----HHHHHHHHHHH---HHHHHHHHHHHHHHHH------------HHHHHHHHHHHHH-------HHHHHHHHHHHHH------EEE-------------------------EEEEE-------------HHHHHHHHHHHHHHHHHHHHHH-----HHHHH----HHHH----EEEEEE---HHHHHHHHHHHHHHHHHHHHHHH-----EEEE-----------------EEEEEEEEEEE---------EEE--HHHHHHHHHHHHHHH--------EEEEEEEE----HHHH-----------------------------------------------------------------------------------------------------------------------------------------EEE PAPOLB_1 sable -----------------------------------HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHH----EEEEE-HHHH--EEE--EEEEEEEEE----HHHHH-HHHHHHHH------EEEE-----EEEEEE---EEEEEEEEEEE--EEE-------HHHH------HHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHH-EEE----EEEHHHHHHHHHHHHHH-----HHHHHHHHHHHHH------EEE------------EEE----HHHHH--EEEEE---EEEEE-----HHHHHHHHHHHHHHHHHHHHHHH----HHHH----------EEEEEEEEEE--HHHHHHHHHHHHHHHHHHHHHHHH---EEEEEEE--EEEE--------EEEEEEEEEEEEE-------EEE--HHHHHHHHHHHHHHHHHH--EEE-EEEEEEEE--HHH--------------------------------------------------------------------------------------------------------------------------------------------EE- PAPOLB_1 proteus --------------------------------HHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHH---EEEE----E-----------EEEE------HHHHHHHHHHHHHH-HHHHHH---------EEEEEE---EEEHHHHH---------------HHHH---HHHHH-----HHHHHHHHH---HHHHHHHHHHHHHHHHH-------------HHHHHHHHHHHHH----HHHHHHHHHHHHHH-------EE--------------------------------------------HHHHHHHHHHHHHHHHHHHHHHH----HHHHH----HHHH---EEEEEEE---HHHHHHHHHHHHHHHHHHHHHHHH---EEE--------------------EEEEEEEEEEEE-------EEE----HHHHHHHHHHHHHHHHH-----EEEEEEEEHHHHHHH--HHH--------------------------------------------------------------------------------------------------------------EEEE-EEE------------EEEE- PAPOLB_1 sspro4 --------------------------------HHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHH---EEEEEE-------------EEEEEEE-----HHHHHHHHHHHHHH----EEEEEE----EEEEEEEEE-EEEEEEEEE---------------HHH----HHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHH-----HHHHHHHHHHHHHH------EEEE-------------------------EEE--------------HHHHHHHHHHHHHHHHHHHHHHH----HHHHH---HHHHHH--EEEEEEE---HHHHHHHHHHHHHHHHHHHHHHHH----EEE------------------EEEEEEEEEEEE-------EEE--HHHHHHHHHHHHHHHH--------EEEEEEEE-HHHHHHH--HHH--------------------------------------------------------------------------------------------------------------------------------------- PAPOLB_1 psspred --------------------------------HHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----------EEEEE---EEE----------EEEEE-----HHHHHHHHHHHHHH-----EEEEE---E-EEEEEEE--EEEEEEEEEE--------------HHHH---HHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHH--HHHHH--HHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHH-----EEEE--------------------------EE---------------HHHHHHHHHHHHHHHHHHHHHHH----HHHHH---HHHHHH--EEEEEEE---HHHHHHHHHHHHHHHHHHHHHHHH---EEEEEE----------------EEEEEEE-E----------EEEE--HHHHHHHHHHHHHHHH-------EEEEEEE--HHHHHHH--HHHH----------------------------------------------------------H-----------------------------------------------------------------------EEE- PAPOLB_1 spineX ---------------------------------HHHHHHHHHHHHH--------HHHHHHHHHHHHHHHHHHHEEEEEEEE------HHH-----EEEEE--------------EEEEE------HHHHHHHHHHHH------EEEEEEEEEEEEEEEEEE--EEEEEEEEEEE---------------H----HHHHHH--HHHHHHHHHHH---HHHHHHHHHHHHHHHHH------EE-EE-HHHHHHHHHHHH-------HHHHHHHHHHHHH-------EEEEE-----EE---------------EEEEE----------------HHHHHEEEEEEEEEEEEEEE----EEEEE-------------EEEEEE---HHHHHHH--------EEE---------EEEEEE----------------EEEEEEEE----------------------------------------EEEEEEEE------------------------------------------------------------------------------------------------------------------------------------------------EEE- PAPOLB_1 raptorxss --------------------------------HHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHH-----EEEEEE---H---------EEEEEEE-----HHHHHHHHHHHHH------EEEEE------EEEEEE--EEEEEEE-E---------------HHH-----HHHH---HHHHHHHHHHH-----HHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHH-----HHHHHHHHHHHHHH-------EEE---------------------------E--------------HHHHHHHHHHHHHHHHHH-HHHH----HHHHH----HHHH-----EEEEE---HHHHHHH---HHHHHHHHHHHHHH-----EEEE----------------EEEEEEEEEEEEE------EEE----HHHHHHHHHHHHHHH-------EEEEEEEE-HHHHHHH--HHH----------------------------------------------------------------------------------------------------------------------------------EEEE- PAPOLB_1 SPARROW --------------------------------HHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHH-------------EEEEE---------------E--E------HHHHHHHHHHHHHH-----EEEE----EE-EEEEEE---EEEEEE-----------------HH-----HHHHHHH--HHHHHHHHHH----HHHHHHHHHHHHHHHH------------HHHHHHHHHHHHHH-----HHHHHHHHHHHHH-------EEEE-------------------------E----------------HHHHHHHHHHHHHHHHHHHHHH-----HHHHH---HHHHH-----EEEEE---HHHHHHH------HHHHHHHHHH--------------------------EEEEEEEEEEE-------------HHHHHHHHHHHHHHHHH--------EEEEEEE-----------HH------------------------------------------------------------------------------------------------------------------------------------EE- PAPOLB_1 *SPARROW -----------------HH-------------HHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHH--EEEEE-EEEEEE--------EEEEE-EEEEHHHHHHHHHHHHHH--HHHHHHH---H----EEEEE----EEEEEHHHE------------HHHHHH--HHHHHHE------HHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHH-----HHHHHHHHHHHHHH------EEEE--H------EEE-------H----------------------HHHHHHHHHHHHHHHHHHHHHHHHHH-HHHHHHH--HHHHHHHEEEEEEE---HHHHHHHHHHHHHHHHHHHHHHHH--EEEEE-------------------EEEEEEE-EEE--------EEEEEE-HHHHHHHHHHHHHHHHH-----EEEEEEEE---------HHHHHH---------------------------------------------------------------------------------------------------------------------------------EEE PAPOLB_1 HMMSTR --------------------------------HHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHH--E-EEEEEHHHHH--------EEEEEEE-----HHHH--HHHHHHH----EEEEEEE------EEEEEE--EEEEEEEEE-----E--------HHHH----HHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHH---E--HH--E-HHHHHHHHHHHHHH-----HHHHHHHHHHHHH-------E--------------------HHHHH----EE-------E------HHHHHHHHHHHHHHHHHHHHHH-----HHHH-----HHHH--EEEEEEEEE--HHHHHHHHHHHH--HHHHHHHHH----EEEEEE----EE----------EEEEEEEEEEE-------------HHHHHHHHHHHHHHHHH--------EEEEEEEEHHHHHHH-----------------EEEE-------------------------------------------E--------EEEEE----------------------------------EEEEEE--EEE------------EEEE- PAPOLB_1 porter ---EEE--------------------------HHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHH---EEEEE--E-----------EEEEE------HHHHHHHHHHHHHHHHHHH-EEE------EEEEEEE--EEEEEEEE---------------HHHHH---HHHHHH----HHHHHHHHH----HHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHHHH-----HHHHHHHHHHHH--------EEE----------------------------------------HH-HHHHHHHHHHHHHHHHHHHHHHH----HHHHH---HHHHHHHEEEEEEEE---HHHHHHHHHHHHHHHHHHHHHHHH----HHH-------------------EEEEEEEEEEEE--------EEEEEEHHHHHHHHHHHHHH--------EEEEEEEEHHHH-----HHH------------------------------------------------------------------------E----------------------------------------------------------EEE- PAPOLB_1 spine --------------------------EE-------HHHHHHHHHHH--------HHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHH-----EEEE---EEEE--------EEEE---------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHH-----------HHHHHH--------------HHHHHH------HHHHHHHHHHHHHH--HHHHHH-------HHHHHHHHH------HHHHHHHHHEEEE--------------------------------------------------EEEEE--HHHHHHHHHHHHHHHHHHHH-HHHHHHHHH----------EEEEEE----HHHHHHHHHHH---EEEEEE------EEEEE---------------HHHHHHHEEEE----------EEEEEEE-------HHHHHHHH-HHHHHH-HHHHHHHHHHHHHHHH----------------HHHHH-----------------------------EEE--------HHHHHHHHHHHHHHHHEE-----------EEE-----------------HHHHHHHH---EE-----HHHHHHHHEEEE PAPOLB_1 nnssp --------------------------------HHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHH-----EEEE-HHHHH--------EEEEEEE-----HHHH--HHHHHHH----EEEEEEE------EEEEEE--EEEEEEEEE--------------HHH-----HHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHH------------HHHHHHHHHHHHHH------HHHHHHHHHHHHH------EEEE--------------------------EE--------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-HHHHHH--EEEEEE-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------------HHHHHHHHHHHH---------EEEEEEEEE-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHH-----------------------------EEEEEEEEEEEEEE----------EEEE- PAPOLB_1 pssfinder --------------------------EEE-----HHHHHHHHHHHH-------HHHHHHHHHHHHHHHHHHHHHHHHHHH-------HHHH----EEEEEE------------EEEEE----------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHH-------------------------------HHHH--------HHHHHHHHHHHHHH---------------HHHHHHHHH------HHHHHHHHHHEEE-------------------EE------------EEEEEEE---------EEEEEEE----HHHHHHHHHHHHHHHH--HHHHHHHH-----------EEEEEE----HHHHHHHEEE----EEEEEEE-----EEEEEE--------------HHHH-EEEEEEE--------EEEEE-----HHHHHHHHHHHH--HHHHHHHHHHHHHHH-HHHHHHH-------------------------------------------------------------HHHHHHHHHHHHHH----HHH---------------------------HHHHHHHHH------------HHHHHHHHHH PAPOLB_1 sspal -------------------------EEEEE----HHHHHHHHHHHHH----HHHHHHHHHHHHHHHHH-HHHHHHHHHH-----------------EEEE--EEEEEEE----------------HHHHHHHHHHHHH--HHHHHHHHHHHHH--EEEEEEE---HHHHHHHHH---HHHHHHHHHHHHHH---EEEEEEE----HHHHHHHHH-----HHHHHHHHHHHHH--------------HHHHHHHHHEEEEE-----EEEEEEEEEEE--------EEEE-------------------------------------EEEEEEE-HHHHHHHHHH-EEEEEEEEE-HHHHHHHHH---HHHHHEEEEEEE----HHHHHHHHH-EEEEEEEEEE-------EEEE------------HHHHHHHEEEEEEE-----------EEEEEEE-----------HHHHHHHHHHH---HHHHHHHHHHHHHHH----------------------------------------EEEEEEE-------------HHHHHHHHHH-----------------------------------------EEEEEEE-EEEEE--HHHHHHHHH---- PAPOLB_1 ssp ----------------------------------HHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHH------HHH---EEEEEEE-EE-----------EEEEE-----HHHHHHHHHHHHHH-----EEEEE----EEEEEEEEE--EEEEEEEEH--------------HHHHH-HHHHHH-----HHHHHHHHH------HHHHHHHHHHHHHHH---------HHHHHHHHHHHHHHEE-----HHHHHHHHHHHHE------EEEEE-------------------------------------------HHHHHHHHHHHHHHHHHHHHHH----HHHHHH----HHH-EEEEEEEE----HHHHHH-E-EHHHHHHHHHHHHHH---EEEEE-----------------EEEEEEEEEEEEE------EEEEEEEHHHHHHHHHHHHHHHH------H-EEEEEEEHHHHH----HHH--------------------------------------------------------------------------------------------------------------------------------------- PAPOLB_1 sspred --------------------------------HHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHH-------------EEEEE-------------EEEEEE------HHHHHHHHHHHHHH------EEEE----EEEEEEEE---EEEE-------------------HH-------------HHHHHHHHHHHH---HHHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHH-----HHHHHHHHHHHHH-------EEEE-------------------------EEE--------------HHHHHHHHHHHHHHHHHHHHH------HHHHH-------------EEEE----HHHHHHHH--HHHHHHHHHHHHH------EE------------------EEEEEEEEEEE---------EEE--HHHHHHHHHHHHHHH--------EEEEEEEE-------------------------------------------------------------------------------------------------------------------------------------------------E-- PAPOLB_1 netsurfp --------------------------------HHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HH------EEEEEEHHHH--------EEEEEE-------HHHHHHHHHHHHH-----E-EE-----EEEEEEEE---EEEEEEEE--------------HHHHH---HHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHH-----------HHHHHHHHEEHHHH-----HHHHHHHHHHHHHHH-----EEE-------------------------EEEE--------HHH----HHHHHHHHHHHHHHHHHHHHHH----HHHHH--HHHHHHH--EEEEEEE---HHHHHHHH-HHHHHHHHHHHHHHH----EEEE-------------------EEEEEEE-----------EE-----HHHHHHHHHHHH---------EEEEEEEE---HHHHH-------------------------------------------------------------------------------------------------------------------------------------------- PAPOLB_1 soprano --------------------------------HHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHH----EEEEE---E---------EEEEEE------HHHHHHHHHHHHHH-----EEEEE-----EEEEEEE---EEEEEEEE---------------HHH----HHHHHH---HHHHHHHHHH----HHHHHHHHHHHHHHHH------------HHHHHHHHHHHHHH-----HHHHHHHHHHHHH-------EEE---------------------------EE--------------HHHHHHHHHHHHHHHHHHHHHHH----HHHHH----HHHH---EEEEEEE---HHHHHHHHHHHHHHHHHHHHHHH----EEEE------------------EEEEEEEEEEE---------EEE---HHHHHHHHHHHHHHH--------EEEEEEE-HHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------EE- PAPOLB_1 consensus MATEIGSPPRFFHMPRFQHQAPRQLFYKRPDFAQQQAMQQLTFDGKRMRKAVNRKTIDYNPSVIKYLENRIWQRDQRDMRAIQPDAGYYNDLVPPIGMLNNPMNAVTTKFVRTSTNKVKCPVFVVRWTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDSPVRAMTWSHNDMWMLTADHGGYVKYWQSNMNNVKMFQAHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERILRDTCFHHCRCYFLSVKR WDR33_3 sequence --------------------------------------EEEE----EEEE-----EEE-------------EE-----EEEE-----EEEEE-----EEE------EEEEEE-----EE--EEEEEE-----EEEEE-----EEEEE-----EEE--------EEEEEE-----EEEEE-----EEEEE-----EE--------EEEEEE-----EEEEEE----EEEEE----EEEEEE--------EEEEEEE-- WDR33_3 psipred -------------------------HHHHH------EEEEE-----EEEE-----EEEE--------EEEEEE-----EEEEE----EEEEE-----EEEE-----EEEEEE--------EEEEEEE-----EEEE-----EEEEEE-----EEEEEE-----EEEEEE----EEEEE-----EEEEEE-----EEEEE----EEEEEEE-----EEEE-----EEEEEE-----EEEEE--------EEEEEE--- WDR33_3 prof ---------------EEE-------------------EEEEE----EEEEE----EEEEEE------EEEEE-----EEEEEE----EEEEE-----EEEE-----EEEEEEE--------EEEEEE-----EEEEE----EEEEEE-----EEEEEE-----EEEEEE-----EEEEE----EEEEEE----EEEEEE-----EEEEEE-----EEEEE----EEEEE-----EEEEEEE-------EEEEE---- WDR33_3 jnet -------------------------------------EEEEE----EEEE-----EEE--------------------EEEE-----EEEEE-----EEE--------EEEE--------EEEEEEE-----EEEEE----EEEEE-------EEEE------EEEEEE-----EEEE-----EEEEE------EEEE------EEEEEE-----EEEE-----EEEEEE-------EE----------EEEEEE-- WDR33_3 sable -------------------------EE--------EEEEEEE---EEEEEE----EEEEE-----EEEEEE-----EEEEEEE----EEEEEE----EEEEE----EEEEEE--------EEEEEEE----EEEEEE----EEEEEE----EEEEEEE-----EEEEEE----EEEEEE----EEEEEE----EEEEEE-----EEEEEE----EEEEEE----EEEEEE----EEEEEEE--------EEEEEEE- WDR33_3 proteus --------------HHHH-----------HHHHHHHHH--------HEH-------EEEE--H-----EEEEE-----EEE-----EEEEEE-----EEE-------EEEEEE--------EEEEEE-----EEEEE----EEEEEE-----EEEEEE-----EEEEEE-----EEEE-----EEEEEE----EEEEEE-----EEEEEE-----EEEEE----EEEEEE-----EEEEEE-------EEEEEEE-- WDR33_3 sspro4 ---------HHH-------------EEEE--------EEEEE----EEEEEE---EEEEE-----EEEEEE-----EEEEEEE----EEEEEE----EEEEEE----EEEEE---------EEEEEE-----EEEEEE---EEEEEE-----EEEEE------EEEEEE-----EEEEEE---EEEEEE-----EEEE------EEEEEE-----EEEEEE---EEEEEE----EEEEEE---------EEEEEEE- WDR33_3 psspred ----------H----------------EE----------EEE----EEEEEE----EE----HHHHHHEEE------EEEEEE----EEEEEE----EE-E-----EEEEEEE-------EE-EEEEE----EEEEE----EEEEEE----EE-EE-------E-EEEEE----EEEEEE---EEEEEE-----EEEEE-------EEEEE----EEEEEE---EEEEEE-----E-EEEE-------EEEEEEE-- WDR33_3 spineX ---EEE--------EEEE-------------------EEEEE----EEE------EEEE----------EEE------EEE------EEEEE-----EE------EEEEEE----------EEEEEE-----EEEE-----EEEEE-------EEE--------EEEEE-----EEEE-----EEEEE------EEE-------EEEEEE-----EEE------EEEEE------EEEE----------EEEEEEE- WDR33_3 raptorxss -------------------------E-----------EEEEE----EEEEEE----EEE------HHHHE------EEEEEEE----EEEEE-----EEEEEH---EEEEEE-------E-EEEEEE-----EEEEEE----EEEE------EEEEE------EEEEEE-----EEEEEE---EEEEEE-----EEEEE-----EEEEEE-----EEEEEE----EEEEE----EEEEEEE---EE--EEEEEEE-- WDR33_3 SPARROW -----------------E-------EE----------EEEEEE-----E--H------H-------E---------EEEEEE-----EEEEE-----EEE--E-E-EEEEE------E---EEEEEE------EE--E---EEE--E-----EE-E-E-----EEEEEE----------HH-------E----E----------EEEEEE------EE--E--------E-----EEEE----------EEEEEE-- WDR33_3 *SPARROW ---------EEE----EEE-HHHHHHHHHHH-----EEEEE-----EEEE-----EEEEEE------EEEEE-----EEEEEE----EEEEE-----EEEE-----EEEEEE--------EEEEEEE-----EEEE-----EEEEE------EEEEEE----EEEEEEE-----EEEE-----EEEEE------EEEEE----EEEEEEE-----EEEE-----EEEEE------EEEEEE-------EEEEEE--H WDR33_3 HMMSTR ----------------------------------------------EEEE-----EE----HHHHHHHHHHHH-----EEE------EEEE--------------EEEEE-----------EEEEEE-----EEEEEE---EEEEEE-----EEEEEE-----EEEEEE-----EEEEEE----EEEEE----EEEEE------EEEEEE-----EEEEEE----EEEEE-----EEEEEE----EEEEEEEEEE-- WDR33_3 porter -----------EEEEE----------EEEEE------EEEE-----EEEE-----EEEEEE-----EEEEE-----EEEE------EEEEEE-----EEEE------EEEEEEEE------EEEEE------EEEE-----EEEEEE-----EEEEE------EEEEEE-----EEEE-----EEEEEE-----EEEE------EEEEEE-----EEEE------EEEEE-----EEEEE---------EEEE---- WDR33_3 cdm -----------EEEEE----------EEEEE------EEEE-----EEEE-----EEEEEE-----EEEEE-----EEEE------EEEEEE-----EEEE------EEEEEEEE------EEEEE------EEEE-----EEEEEE-----EEEEE------EEEEEE-----EEEE-----EEEEEE-----EEEE------EEEEEE-----EEEEEE----EEEEE-----EEEEE---------EEEE---- WDR33_3 fdm ----------------------HHH------HHHHHHH----HHH---EEEE---EEEHH--EEEEE-EE-----HHHHHHH------EEEEEEEEEEE----------EEE---------EEEEEE-----EEEEEE----EEEEE-----EEEEE------EEEEEE-----EEEEEE----EEEEE----EEEEE------EEEEEE-----EEEEEE----EEEEE-----EEEEE-------EEEEEEEE-- WDR33_3 gor --E-------------------HHHHE-----------EEE-----EEEEE-----EE-------EEEEEE-----EEEEEE------E-------------------EEEEE--------EEEEEE-----EEEEE----EEEEEE-----EEEEEEE----EEEEEE-----EEEEE----EEEEEE-----EEEEE-----EEEEEE-----EEEEE----EEEEEE-----EEEEEEE-----EEEEEEEE-- WDR33_3 spine --------------------------------HHHHHHHHHH---HHHHHHHH--------HHHHHHHHHHHHH-HHHHHHH----------------------------EE---------EEEEEE-----EEE--------EE-------HHHHHHH------EEE------EEE-------EEE-------HHHHHHHHHHHHH---------EEEE-----EEHHHHHHH-HHHHHH--------EEEEE--- WDR33_3 nnssp ---------EEEEE-----------------HHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHHHHHHHH----------------------EEEEEEEE---------EEEEEE-----EEEE-----EEEEEE-----HHHHHHH----EEEEEE-----EEEE-----EEEEEE-----HHHHHHHHHHHHHH-------EEEEEE------HHHHHHHHHHHHHHHH-------------- WDR33_3 pssfinder HHH-------EEE--------HHHH-------HHHHHHHHH---HHHHHHHHHH--------HHHHHHHHHHH--HHHHHHH-----------------------EEEEEEE-----EEEEEEEEEE-----EEEE-----EEEE-------HHHHHHH----EE-EE------EEEE-----EEEEE------HHHHHHHHHHHHHH-------EEEE-----EEEEEHHHHHHHHHHHHH------EEEEEEE-- WDR33_3 sspal ------------HHHHHHHHH-----------HHHHHHHHHEEE-HHHHHHHHH--------HHHHHHHHHHHH-------------------------------EEEEEEE-----EEEEEEEEEEE--------------EEEEEEEEEHHHHHHHHH---EEEEEEE-------------EEEEHHHHHHHHHHHHHHHHHH-------------------EEEHHHHHHHHHHHHHH------EEEEEEEE-- WDR33_3 ssp -----------------------EEEEEE---------EEE-----EEEEEE---EEEEE----HEEEEEEEE---EEEEEEE----EEEEEE--------------EEEEEE-------EEEEEEEEE---EEEEEE---EEEEEEE---HEEEEEEE----EEEEEEEE---EEEEEE---EEEEEE----EEEEEEE-----EEEEEE----EEEEE----EEEEEEE----EEEEE--------EEEEEEE-- WDR33_3 sspred -------------------------------------EEEE-----EEEE------EE--------------------EE--------EEEE------EE------EEEEEE---------EEEEEE-----EEEE-----EEEEE-----------------EEEEEE-----EEEE-----EEEEE------EE--------EEEEEE-----EEEE-----EEEEEE-----EEEE----------EEEEE--- WDR33_3 netsurfp -------------------------------------EEEEE----EEEE------EE---HHHHHH----------EEEEEE-----EEEE-----EEE-------EEEEEE-------EEEEEEE-----EEEEE----EEEEE------EEEEEE-----EEEEEE-----EEEEE----EEEEEE-----EEEEEE----EEEEEE-----EEEE-----EEEEEE-----E-EEEE--------EEEEEE-- WDR33_3 soprano -------------------------------------EEEE-----EEEE-----EEE---------EEEE------EEEEE-----EEEEE-----EEE------EEEEEE---------EEEEEE-----EEEEE----EEEEEE-----EEEEEE-----EEEEEE-----EEEE-----EEEEEE-----EEEEE-----EEEEEE-----EEEEE----EEEEEE-----EEEEE--------EEEEEEE-- WDR33_3 consensus MSAIPAEESDQLLIRPLGAGQEVGRSCIILEFKGRKIMLDCGIHPGLEGMDALPYIDLIDPAEIDLLLISHFHLDHCGALPWFLQKTSFKGRTFMTHATKAIYRWLLSDYVKVSNISADDMLYTETDLEESMDKIETINFHEVKEVAGIKFWCYHAGHVLGAAMFMIEIAGVKLLYTGDFSRQEDRHLMAAEIPNIKPDILIIESTYGTHIHEKREEREARFCNTVHDIVNRGGRGLIPVFALGRAQELLLILDEYWQNHPELHDIPIYYASSLAKKCMAVYQTYVNAMNDKIRKQININNPFVFKHISNLKSMDHFDDIGPSVVMASPGMMQSGLSRELFESWCTDKRNGVIIAGYCVEGTLAKHIMSEPEEITTMSGQKLPLKMSVDYISFSAHTDYQQTSEFIRALKPPHVILVHGEQNEMARLKAALIREYEDNDEVHIEVHNPRNTEAVTLNFRGEKLAKVMGFLADKKPEQGQRVSGILVKRNFNYHILSPCDLSNYTDLAMSTVKQTQAIPYTGPFNLLCYQLQKLTGDVEELEIQEKPALKVFKNITVIQEPGMVVLEWLANPSNDMYADTVTTVILEVQSNPKIRKGAVQKVSKKLEMHVYSKRLEIMLQDIFGEDCVSVKDDSILSVTVDGKTANLNLETRTVECEEGSEDDESLREMVELAAQRLYEALTPVH CPSF3_1 sequence -----------EEEEEE---------EEEEEE--EEEEEE-------------------------EEEEE----------------------EE--HHHHHHHHHHHHHHHHHH----------HHHHHHHHH--EEE----EEEE--EEEEEEE--HH---EEEEEEE--EEEEEE----------------------EEEE------------HHHHHHHHHHHHHHHH---EEEEE----HHHHHHHHHHHHHHHH--------EEEE--HHHHHHHHHHHHHHHHHHHHHHHHHH--------------HHHH-----EEEEE--------HHHHHHHH--------EEEE-------HHHHHH-----------EEEEEEEEEEEE-------HHHHHHHHHH----EEEEE---HHHHHHHHHHHHHHH-------EEEE------EEEEE----EEHEE--------------EEEEEEEE--EE---------------EEEEEEEEEEE----HHHHHHHHHHHH---HH-------EEEEEEEEEEEE---EEEEEE------HHHHHHHHHHHHH----------------HHHHHHHHHHHHHHHHHHHH-----------EEEEEE--EEEEEE----EEEE-------HHHHHHHHHHHHHHHHH----- CPSF3_1 psipred ----------EEEEEE---------EEEEEEE---EEEEE-------------------------EEEEE-HHHHH---HHHHHHH-----EEEE---HHHHHHHHHHHHHHEE----------HHHHHHHHHHEEEEEEEEEEEE--EEEEE----HHHHHHHHHHHH---EEEEE----------------------EEEEEE----------HHHHHHHHHHHHHHHHH---EEEEHHH--HHHHHHHHHHHHHHH--------EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----EEEE---------------EEEEE--HHHH----HHHHHHH-------EEEEEEEE-HHHHHHHH----HHHH-------EEEEEEEEEEEE---HHHHHHHHHHH----EEEE---HHHHHHHHHHHHHHHH------EEEE------EEEEEE--HHHHHHHHHHHH-------EEEEEEEEE---EEEE----HHHH----EEEEEEEEEEEE---HHHHHHHHHHHH---EEEE-----EEEEEEEEEEEE---EEEEEEE-----HHHHHHHHHHHHHH-------------------HHHHHHHHHHHHHHHH-----------EEEEEE---EEEEEEEEEEEEE------HHHHHHHHHHHHHHHHHHH---- CPSF3_1 prof -----------EEEEEE--------EEEEEE----EEEEE------------------------EEEEEE-----------EEEEE-----EEEE---HHHHHHHHHHHHHH------------HHHHHHHHH---EE---EEEE----EEE--------HHHHHHHHH--EEEEE-----------------------EEEEE----------HHHHHHHHHHHHHHHHH----EEEEEE-----HHHHHHHHHHHH---------EEE--HHHHHHHHHHHHHHHHHHHHHHHHHH------------------------EEEEE--------HHHHHHHH--------EEEE--E-----HHHHH-----EE-----EEEEEEEEEE--------HHHHHHHHHH----EEEEEE--HHHHHHHHHHHHHHH--------EEEE-----EEEEE----EEEEEEE-----------EEEEEEEE----EEEEE----------EEEEEEEEEEE-----HHHHHHHHHHHH----EE-----EEEEEE--EEEEE---EEEEEE------HHHHHHHHHHHHHH-------------------HHHHHHHHHHHHHH-------------EEEEEE---EEEEE----EEE-------HHHHHHHHHHHHHHHHHHHH--- CPSF3_1 jnet -----------EEEEE---------EEEEEEE---EEEEE------------------------EEEEEE--------HHHHHHHH------EEE--HHHHHHHHHHHHHHHHHH---------HHHHHHHHHH--EE----EEE---EEEEE---------HEEEEE----EEEEE----------------------EEEEE-----------HHHHHHHHHHHHHHHH----EEEEE----HHHHHHHHHHHHHHH-------EEEE---HHHHHHHHHHHHHHHH-HHHHHHHH---------------HHHH-----EEEEE-------HHHHHHHHHH------EEEEEE------HHHHHH----HHHH----EEEEEEEEEEEE------HHHHHHHHHH-----EEEEE--HHHHHHHHHHHHHHH--------EEEE----EEEEEE-----EEEE--HHH---------EEEEEEE----EEEE-HHHHHHH----EEEEEEEEEEEE---HHHHHHHHHHH----EEE------EEEEEEEEEEEE---EEEEEE------HHHHHHHHHHHHHH--------------------HHHHHHHHHHHHHH-------------EEEEE---EEEEE----EEEE------HHHHHHHHHHHHHHHHHH----- CPSF3_1 sable --------EEEEEEEEE--------EEEEEEE--EEEEE-EEE---------------------EEEEE----------HHHHHH------EEEE-HHHHHHH--HHHHHHHHHHH--------HHHHHHH---EEEE----EEE---EEEEEEEE-----EEEEEEEE--EEEEEE-EEE-------EEEE------EEEEEEE---------HHHHHHHHHHHHHHHHHH-EEEEEEEE---HHHHHHHHHHHHHHH------EEEEEEE--HHHHHHHHHH-----HHHHHHHHH--------EEEEE----------EEEEEEE-------HHHHHHHHH-----EEEEEEE-EEE--HHHHH-----EEE----EEEEEEEEEEEEE---EEEHHHHHHHHHHH--EEEEEEEE-HHHHHHHHHHHHHHHH------EEEE-EEE-EEEEEEE---EEEEE-------------EEEEEEEEE-------------------EEEEEEEEEEEE---HHHHHHHHHHH-----EEE----EEEEEEEEEEEEE---EEEEEEE-----HHHHHHHHHHHHHH--------------------HHHHHHHHHHHHHH------------EEEEEE--EEEEEEE---EEE------HHHHHHHHHHHHHHHHHHH----- CPSF3_1 proteus ----------EEEEEE----------EEEEEE---EEEEE--------------------HHH--EEEEEE--------HHHHHHH------EE-----HHHHHHHHH-HHHHH----------HHHHHHHH--EEEE----EEE----EEEEE---EEEEEEEEEEEE---EEEEE----------------------EEEEEE---------HHHHHHHHHHHHHHHHH----EEEEHHHH-HHHHHHHHHHHHHHH--------EEE--HHHHHHHHHHHHHHHHHHHHHHHHHHH--------------HHHH-----EEEEE--------HHHHHHHHH------EEEEE-EEE---HHHHH------EE-----EEEEEEEEEEEE------HHHHHHHHHH-----EEEEE--HHHHHHHHHHHHHHH-------EEEE------EEEE----HHHHHHH------------EEEEEEEEE----EEE-HHHHHHHHHHHHHHHHHH-E------HHHHHHHHHHH----EEE------HEEEE-EEEEEE---EEEEEEE-----HHHHHHHHHHHH-----HHHHHHHHHH------H-HHHHHHHHHHHHHH----EEE----EEEEEE---EEEEE----EEEE-----HHHHHHHHHHHHHHHHHHH----- CPSF3_1 sspro4 ----------EEEEEEE---------EEEEEE--EEEEEE---------HHH-------------EEEE----HHHHHHHHHHHHHH-----EE--HHHHHHHHHHHHHHHHHHH---------HHHHHHHHHH--EEE--EEEEE--EEEEEEE-------EEEEEEE--EEEEEE----------------------EEEE-----------HHHHHHHHHHHHHHHHHH--EEEEE---HHHHHHHHHHHHHHHHH-------EEEEE-HHHHHHHHHHHHHHHHH-HHHHHHHHH---------EEHHHHHHHH-----EEEE--------HHHHHHHHH------EEEEE-------HHHHHHH----EEEE--EEEEEEEEEEEEE------HHHHHHHHHH----EEEEE---HHHHHHHHHHHHHHH--------EEEE----EEEEEE----EEEEEE-HHHH-------EEEEEEEE---EEEE--HHHHHHHH---EEEEEEEEEEE----HHHHHHHHHHHH---EEEE-----EEEEE--EEEEE---EEEEEEE-----HHHHHHHHHHHHHHH------------------HHHHHHHHHHHHHHHH-----------EEEEEE--EEEEEE----EEE--------HHHHHHHHHHHHHHHHHH---- CPSF3_1 psspred ----------EEEEEE---------EEEEEEE--EEEEEE----------HH--------HH---EEEE----HHHHHHHHHHHHHH----EEEE-HHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHH--EE----EEEE--EEEEEEE------EEEEEEEE--EEEEEE----------------------EEEEE----------HHHHHHHHHHHHHHHHHH--EEEEE-----HHHHHHHHHHHHHHH-------EEEEE-HHHHHHHHHHHHHHHHH-HHHHHHHHH--------------HHHHH-H--EEEEE-------HHHHHHHHHH------EEEEE-------HHHHHHH---E-EE---EEEEEEEEE-EEE------HHHHHHHHHH----EEEEE---HHHHHHHHHHHHHHH------EEEEEE----EEEEEE----EEHHHHHHHHH-------EEEEEEE-----EEEE-HHHHHHH---EEEEEEEEEEEEE---HHHHHHHHHHHH----EEE----EEEEEEEEEEEEEE--EEEEEEE-----HHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---EEEE----EEEEEE--EEEEEE----EEEE-------HHHHHHHHHHHHHHHHHH---- CPSF3_1 spineX ----------EEEEEE-----EE---EEEEEE--EEEEE---------HH----------HH---EEEE-----------HHHH-------EEE--HHHHHHHHHHH-----------------HHHHHHHHHHEEEE----EEEE--EEEEEE--------EEEEEEE---EEEEE----------------------EEEE-----------HHHHHHHHHHHHHHHHHH--EEE------HHHHHHHHHHHHHHH---------EEE---HHHHHHHHHHHHHHHH---HHHHHH---------EEE---HHHH------EEEE---------HHHHHHHH-------EEE--------HHHHHH-------E----EEE---EEEEE-------HHHHHHHHHH----EEEEE-----HHHHHHHHHHHH---------EEEE-----EEEEE----EEEEE-------------EEEEEEEE----EEEE-HHH-------EEEEEEEEEEEE---HHHHHHHHHHH----EEEEE-----EEEEEEEEEEEE---EEEEEEE-----HHHHHHHHHHHHH--------------------HHHHHHHHHHHHHHH------------EEEEEE---EEEEE---EEEEE-------HHHHHHHHHHHHHHHH------ CPSF3_1 raptorxss -----------EEEEE--------EEEEEEEE--EEEEEEE-------HHHH--------HHH--EEEE--HHHHHHHHHHHHEEE------EEE-HHHHHHHHHHHHHHHHHHHH--------HHHHHHHHH-EEEE----EEEE--EEEEEEE--EEEEEEEEEEEE--EEEEE-----------------------EEEEE------E---HHHHHHHHHHHHHHHHH---EEEEEEE-HHHHHHHHHHHHHHHHH-------EEEEE-HHHHHHHHHHHH-HHHH-HHHHHHHH---------EEEE--HHHH-----EEEEEE----H--HHHHHHHHH------EEEE--------HHHHHH-----EEE---EEEEEEEEEEEEEE-----HHHHHHHHHH----EEEEE---HHHHHHHHHHHHHHH--------EEEE-----EEEE------EEHHHHHHHHHHH----EEEEEEEEE--EE--E-HHHHHHHH---EEEEEEEEEEEE---HHHHHHHHHHH----EEEE----EEEEEEE-EEEEEE--EEEEEEE---HHHHHHHHHHHHHHHHHH-----HH----------HHHHHHHHHHHHHHH---HHEEE----EEEEEE--EEEEEE----EEEE-------HHHHHHHHHHHHHHHHH----- CPSF3_1 SPARROW ------------EEEE-------HH---EEEE--EEEEEE---------HH---------HHH--EEE----HHHH-----HHHHH-----------HHHHHHHHHHHHHHHHHH---------HHHHHHHHHHEEEE----EEEE--EEEEEEE--E--EEEEEEEEE--EEEEE------------------HHH--EEEE--HH-------HHHHHHHHHHHHHHHHH---EEEE---H---H-HHHHHHHHHHH---------E-E---HHHHHHHHHHH-HHH--HHHHHHHH---------EEEE--HHHHH----EEEEE------------HHHHH-------EEE---------HHHHH----EEEEE--EEEEEEEEEEEEEEEE---HHHHHHHHHH----EEEEE---HHHHHHHHHHHHHHH--------EEEE-----EEEE------EEH---HHH----------EEEEEE----EEE--HHHHHHHH---EEEEEEEEEEE----HHHHHHHHHHH-----E-------EEEEEEEEEEEE---EEEEEE------HHHHHHHHHHHHHH-------------------HHHHHHHHHHHHHHH-----EE-----EEEEEE---EEEEE----EEE--------HHHHHHHHHHHHHHHHHH---- CPSF3_1 *SPARROW ----------EEEEEE----------EEEEEE---EEEEE-----------------E--H----EEEEEEE-EEH------EEEEE---EEEEEE--HHHHHHHHHHHEEEEE----------HHHHHHHHHHHHEEEEEEEEEE---EEEEE---EEE---EEEEEE---EEEEE-----HHHHHHHHH--------EEEEEEE--------HHHHHHHHHHHHHHHHHH---EE---HH---HHHHHHHHHHHHHH--------EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHH--EEEEE----------HHHHHHHH------EEEE--EEE--HHHHHHHHHHHHHHHH-----EEEEEEEEEEEE---HHHHHHHHHHHH--EEEEEE--HHHHHHHHHHHHHHHHH----EEEEE------EEEEEEEHHHHHHHHHHHHHH------EEE-EEEEE--EEEE--HHHHHHHHHH-HHHHEHEEEEEEHHHHHHHHHHHHHHHHHHHHHHHH---EEEEEEEEEEEEE--EEEEEEE----HHHHHHHHHHHHHHH----HHHHH----------HHHHHHHHHHHHHHHH-----------EEEEEE---EEEEE--EEEEEE------HHHHHHHHHHHHHHHHHHE---- CPSF3_1 HMMSTR ---------EEEEEEEEE--------EEEEEE--EEEEE-----------HH---HHH--HHH--EEE-----HHHH--HHHHHHH-----EEEEEHHHHHHHHHHHHHHH-------------HHHHHHHHH-EEEE-----EEE--EEEEEEE-------EEEEEEE--EEEEE-----------------------EEEEE----------HHHHHHHHHHHHHHHHH---EEEEE-----HHHHHHHHHHHHHHH-HHH----EEEE---HHHHHHHHHHHHHH--HHHHHHH----------EEE---HHH------EEEEE-------HHHHHHHHHH------EEEE--------HHHHH-----EEE-----EEE---EEEE--------HHHHHHHHHHH---EEEEE---HHHHHHHHHHHHHHHH-------EEE-------EEEEE--HHHHHHH-HH---------EEEEEEEE----EEEE----HHHHH---EEEEEEEEEE----HHHHHHHHHHHHH--EEE-------EEEEEEEEEEEE---EEEEEEE-----HHHHHHHHHHHHH--------------------HHHHHHHHHHHHHHH-----EEE----EEEEEEE--EEEEEE---EEEE------HHHHHHHHHHHHHHHHHH----- CPSF3_1 porter -----HHHHHHHHHH-----------EEEEEE---EEEEE---------------------HHHHHHHHH----------------------EEEHHHHHHHHHHHHH----------------HHHHHHHHHHHHHH-HHHHHHHH--EEEEE----HHHHHHHHHHH---EEEE-----HHHHHHHHHHH-------EEEEE------HHHHHHHHHHHHHHHHHHHHH--------EE----HHHHHHHHHHHHH---------EEE--HHHHHHHHHHHHHHHHHHHHHHHHH-----EEEE-----------------EEEE---------HHHHHHHHH------EEEE-------HHHHHH-----EEE-------------EEEE-----HHHHHHHHHH-----EEEE-----HHHHHHHHHHHHHH---EEEEEE-------EEEEEE--HHHHHHHHHHH--------HHHHHHHH-----EEE-------HHHHHHHHHHH-----------HHHHHHHHHH--HHHHHHHHH-HHHHHHHHEEE----EEEE----------------EEEEEE-----HHHHHHHHHHHHHHHEEEHHHHHHHHHHHH----EEE----EEEEEE-----EEE--EEEEE-------HHHHHHHHHHHHHHHHHHH---- CPSF3_1 nnssp -----HHHHHHHHHHHH---------EEEEE----EEEEE--------------------HHHHHHHH-----HHHH-------------------HHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--EEEEEE-HHHHHHHHHHHHHH--EEEEE----HHHHHHHHHHH-------EEEEE------HHHHHHHHHHHHHHHHHHHHH--------HHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----EEEEE---------------EEEEE----------HHHHHHH-------EEEEEE----HHHHHHHH-HHHHHHHH-----------EEEEEE-------HHHHHH----EEEEEE----HHHHHHHHHHHHH----EEEEEEE-----EEEEEEE--HHHHHHHHHHH--------EEEEEEEE----EEEE-----------------------------HHHHHHHH----HHHHHHHHHHHHHH---EEEEE----EEEEEE------------EEEEEEE---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---EEEEE--EEEEEEE--EEEEEEEEEEEEE-------HHHHHHHHHHHHHHHHHH----- CPSF3_1 pssfinder -------HHHHHHHHHHH--------EEEEEE---EEEEE---------------------HHHHHHHEE-----------------------HHHHHHHHHHHHHH---HHH-----------HHHHHHHHHHHH---HHHHHHHH-EEEEEEE----HHHHHHHHHHH---EEE-----HHHHHHHHHHH-------EEEEE--------HHHHHHHHHHHHHHHHHHH----EEEEE----HHHHHHHHHHHHH--------------HHHHHHHHHHHHHHHHHHHHHHHHHH-----EEE------------------EEEE----------HHHHHHH------EEEEEEE-----HHHHH----------------------EEE------HHHHHHHHHH----EEEEEE--HHHHHHHHHHHHHHH----EEEEEEE-----EEEEEE---HHHHHHHHHH---------EEE-EE------EEE---------HHHHHHHHHHH---------HHHHHHHHHHH--HHHHHHH-HHHHHHH--EEEE----EEEE----------HHHHH-HHHHHH----HHHH-HHHHHHHHH-----HHHHHHHHHHH----EEEE----EEEEEE----EEEE----EEE-------HHHHHHHHHHHHHHHHHHH---- CPSF3_1 sspal -----HHHHHHHHHH---------EEEEEEE-----EEEEEEEE-----------------HHHHHHHHHEEEEEEE-----------------HHHHHHHHHHHHH--EEEEE---HHHHHHHHHHHHHHHHH--------------EEEEEEE------HHHHHHHHH-EEEEEEE---HHHHHHHHHHHH------EEEE-------HHHHHHHHHH---------------------HHHHHHHHHHHHHHHHH------------HHHHHHHHHHHHHHHHHHHHHHHHHHEEEE--EEEEEEE-------------EEEE---------HHHHHHHHH-------EEEE-EEEEHHHHHHHH-----------EEEEEEE-EEEEEEE--HHHHHHHHHHHHHH---EEEEHHHHHHHHHHHHHH--------EEEEEEE---------HHHHHHHHHHHHHHHH---------EEEEEEE-------------------------------------HHHHHHHHH---HHHHHHHHHHHHHEEEEEEEE----EEEEHHHHH--------EEEEEEEEEE---HHHHHHHHHHHHHHHH---HHHHHHHHH------EEEEE---EEEEEEE---------EEEEEEE------HHHHHHHHHHHHHHHH------ CPSF3_1 ssp ----------EEEEEEEE-------EEEEEEE---EEEEE-------HHHHH-HH---------EEEEE-------HHHHHHHHHHH-----EE--HHHHHHHHHHHHHHHHHH----------HHHHHHHHH---------EEEE--EEEEEEE-------EEEEEEE--EEEEEEE--------------------EEEEEE------------HHHHHHHHHHHHHHHH---EEEEEE--HHHHHHHHHHHHHHHHHH-----EEEEE-HHHHHHHHHHHHHHHH--HHHHHHHH---------------HHHH-----EEEEE-------HHHHHHHHHHH-----EEEEEEE-----HHHHHHH----EEEE---EEE-EEEEEEEEE-----HHHHHHHHHHH---EEEEE---HHHHHHHHHHHHHHH-------EEEEE----EEEEE------HHHHH------------EEEEEEEEE---EEEE----HHH------EEEEEEEEEE----HHHHHHHHHH-----EEEEE-HHHH-EEH-EEEEEEE--EEEEEEE------HHHHHHHHHHEEEE-------HHHH-------HHHHHHHHHHHHHHH------------EEEEEE--EEEEEE----EEE-------HHHHHHHHHHHHHHHHHH----- CPSF3_1 sspred ----------EEEEEE---------EEEEEEE---EEEEEE--------HH---------H---EEEEEEEEHHHHHHHHHHHHHH------EE----HHHHHHHHHHHHHHHHHH--------HHHHHHHHH---------EEEE--EEEEEE----EE-EEEEEEEE--EEEEEE----------------------EEEEEE------------HHHHHHHHHHHHHH---EEEEEEE---HHHHHHHHHHHHHHH--------EEE---HHHHHHHHHHH-HHH--HHHHHHHHH--------------HHHHHH---EEEEE---H----HHHHHHHHH------EEEEEEEE-----HHHHH-----EEE----EEEEEEEEEEE-------HHHHHHHHHHH----EEEE---HHHHHHHHHHHHHHHHH------EEEE-----EEEE-------EEE----HHHH-----EEEEEEEE-----EEE--HHHHHH----EEEEEEEEEEEE---HHHHHHHHHHH-----EEE-----EEEEEEEEEEEEE--EEEEEEE-----HHHHHHHHHEHHHHH----HH-H-----------HHHHHHHHHHHHHH-----EE-----EEEEEE---EEEEE----EEE--------HHHHHHHHHHHHHHHHHH---- CPSF3_1 soprano ----------EEEEEE----------EEEEEE---EEEEE---------------------H---EEEE----------HHHHHHH------EEE-HHHHHHHHHHHHHHHHHH----------HHHHHHHHHH-EEE----EEEE--EEEEEEE-------EEEEEEE--EEEEEE----------------------EEEEE----------HHHHHHHHHHHHHHHHH----EEEEE----HHHHHHHHHHHHHHH--------EEE--HHHHHHHHHHHHHHHHHHHHHHHHHH---------------HHHH-----EEEEE--------HHHHHHHHH------EEEEE-------HHHHHH-----EEE----EEEEEEEEEEEE------HHHHHHHHHH----EEEEE---HHHHHHHHHHHHHHH-------EEEE------EEEEE----H-HHHH-HHH--------EEEEEEEE----EEEE----HHHH----EEEEEEEEEEE----HHHHHHHHHHH----EEEE-----EEEEEEEEEEEE---EEEEEEE-----HHHHHHHHHHHHHH-------------------HHHHHHHHHHHHHHH-----EE-----EEEEEE---EEEEE----EEEE------HHHHHHHHHHHHHHHHHH----- CPSF3_1 consensus FASGGSDGSLLFWHVGVEKEVGGMEMAHEGMIWSLAWHPLGHILCSGSNDHTSKFWTRNRPGDKMRDRYNLNLLPGMSEDGVEYDDLEPNSLAVIPGMGIPEQLKLAMEQEQMGKDESNEIEMTIPGLDWGMEEVMQKDQKKVPQKKVPYAKPIPAQFQQAWMQNKVPIPAPNEVLNDRKEDIKLEEKKKTQAEIEQEMATLQYTNPQLLEQLKIERLAQKQVEQIQPPPSSGTPLLGPQPFPGQGPMSQIPQGFQQPHPSQQMPMNMAQMGPPGPQGQFRPPGPQGQMGPQGPPLHQGGGGPQGFMGPQGPQGPPQGLPRPQDMHGPQGMQRHPGPHGPLGPQGPPGPQGSSGPQGHMGPQGPPGPQGHIGPQGPPGPQGHLGPQGPPGTQGMQGPPGPRGMQGPPHPHGIQGGPGSQGIQGPVSQGPLMGLNPRGMQGPPGPRENQGPAPQGMIMGHPPQEMRGPHPPGGLLGHGPQEMRGPQEIRGMQGPPPQGSMLGPPQELRGPPGSQSQQGPPQGSLGPPPQGGMQGPPGPQGQQNPARGPHPSQGPIPFQQQKTPLLGDGPRAPFNQEGQSTGPPPLIPGLGQQGAQGRIPPLNPGQGPGPNKGDSRGPPNHHMGPMSERRHEQSGGPEHGPERGPFRGGQDCRGPPDRRGPHPDFPDDFSRPDDFHPDKRFGHRLREFEGRGGPLPQEEKWRRGGPGPPFPPDHREFSEGDGRGAARGPPGAWEGRRPGDERFPRDPEDPRFRGRREESFRRGAPPRHEGRAPPRGRDGFPGPEDFGPEENFDASEEAARGRDLRGRGRGTPRGGRKGLLPTPDEFPRFEGGRKPDSWDGNREPGPGHEHFRDTPRPDHPPHDGHSPASRERSSSLQGMDMASLPPRKRPWHDGPGTSEHREMEAPGGPSEDRGGKGRGGPGPAQRVPKSGRSSSLDGEHHDGYHRDEPFGGPPGSGTPSRGGRSGSNWGRGSNMNSGPPRRGASRGGGRGR WDR33_1C sequence ---------EEEEEEEEEEE----HHHHHHHHHHHHH---------------------------HH----------------------------------HHHHHHHH------------HH-----------EEE---------EEE------HHHHHHHHHH--------------HHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- WDR33_1C psipred --------EEEEEEEEEEEEE--EEEHHHHHHHHHHH-----EEE---------------------EEEEEEE------------EEE----EEE-------------------EEEEEEEEE-------EEEEEEE--------EEEEE-----EEEEEHHH------------------------HHH-EEEEE----EEE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- WDR33_1C prof ---------EEEEEEEEEE-----EEEHHHHHHHH------------------------------HHHHHHHH-----------------------------------------EEEEEEEEE-------HHHHHHHH------EEE--------HHHHHHHH-----------------------------HHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- WDR33_1C jnet ---------EEEEEE---E-----EEH----EEEEE-----EEE---------EEEE-------HH------------------------------------HEEEEEE-----------EEEE-------HHHHHHH------HHE---------HHHHHHH----------------------------------HH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- WDR33_1C sable ---------EEEEE-HHHH----EEEE---EE---------EEE----EE---EEEEE-----HHHH-HHHH------------EEE----EEEE--------EEEEEE----------EEEEEE--------HHHHHHHHH------------HHHHHH---------------HHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- WDR33_1C proteus -------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----EEEE---HHHHHHHH---------HHH------------EEE--------EE--------H---HHHHE-------EEEE----------HHHHHHHH-------------------HHHH----------------------------E------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ WDR33_1C sspro4 ----------EEEE----------EE---------------------------EEEEE------------HHH-------------------EE---------EEEEEE----------EEEEEE---------E---------E----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- WDR33_1C psspred ---------EEEEE---------E-------HHHHHH-----EEE---------------------------------------------------------HHHHHH--------------E--------------------------------HHHHHHH----------------------HHHHHHHHHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- WDR33_1C spineX ---------EEEEEE--------HHHHHHHHHHHHH------E------------EE------------------------------------E---------EEEEEEEEE-----------------------------------------------------------------------E------------------------E------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- WDR33_1C raptorxss --------EEEEEEEEEE------EEE---HEH-----HHHHEE---EEE---EEEEE----HHHHH---------------EE--EE----EE-------EEEEEEEEE----------EEEEE------HHHH--HHHHHHHHH---------HHH-HHHHHH--------------HHH----------EEE--HEEEE--------------------EEEEEE--E-E------------------------------------------------------------------------------------------E--------------------------------------------------------------------------------------------------------------------------------------E-EE-E-EEEEE-------------------------E----EEEE-E--E--E--E--E------------------------E------------------------------EEEE-------------------------------------------------------------------------------EEEEEEEEEEEEEEEEEEEEEEE-E-EEEEEEE-E----------------------------------------------EE-E---------------------------------------------------------E----EEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEE--EEE-------------------------------------------------EEEEEEEEEEEEEEEEEEEEEEEEEE----------------E-E---------------------------------- WDR33_1C SPARROW --------EEEEEEE-HHHHH-HHHHHH--HHHHHH-------E-----E---EEEE-----HHHHHHHEHHH------------EE---------------EEEEEEEEE---------EEEEE-----EEEEEE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- WDR33_1C *SPARROW ---------EEEEEEEEEEEE---EEEEE-EEEEEEE-----EE----------EEE-------HHHHHEHHHHH--------EEE------EEE------HHHHHHH-HHHHHH--EEEEEEE----HHHHHHHHHH--------EEEE-----HHHHHHHHHH--------HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ WDR33_1C HMMSTR ---------EEEEE----------H------EEEEEE----EEEE--------EEEE--------HHHHH-------------------------------HHHHHH-------------------------HHHH-------------------HHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- WDR33_1C porter --------EEEEEEE-------HHHHHHH-HHHHH-------EE----------EEE------HHHHHH--------------------------------HHH-----------------------------------------------------HHHH---------------------HHHHHHH------HHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- WDR33_1C spine ---------EEEEE-----------------EE---------EEE---------EE------------------------------------EE---------HHHHHHH----------EEEE--------HHHHH---------------------------------------------EE-------HHHHHHHHHH------HHHHHHHHHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- WDR33_1C nnssp --------EEEEEEEEEEEEE--HHHHHHHHHHHHH------EEEE-------EEEEEE-------------------------------EEEEE-----HHHHHHHHHHHHH------------------HHHHHHHHHHH-------------HHHHHHHHH---------------HHHHHHHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHH----------------------------------------HHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHH-------HHHHHHH------------------------------------------------------------------------------------------HHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ WDR33_1C pssfinder ---------EEEEE-----EEEEEEEE----HHHH-HHHHHHHH---------EE--------------------------------------EE------------------------EEEEE-------------------------------EEEEEHHH---------EEEHHH----EEEEEHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EE---------------------------------------------------------------------------------------------------------------------------------------EE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------- WDR33_1C sspal ---------EEEEEEE-----------------------EEEEEEE----------------HHHHHHHHH--------------------EEEE------HHHHHHHHH---------EEEEEEE--HHHHHHHHHH---------------HHHHHHHHHHH---------HHHHHHHHH--HHHHHHHHHHHHHHHHHEEEHHHHHHHHHH-HHHHHHHHHHHH----------------------------------HHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHH---------------------------------------------HHHHHHHHH-------HHHHHHHHH--------------------------------------------------------------------------------------HHHHHHHHHHH------------------------------------------------------------------------------------------------HHHHHHHHH--------------------------------------------------------------------------------------- WDR33_1C ssp ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ WDR33_1C sspred ---------EEEEEEHHHHH---HHHHHHHHHHHHH-------------------EE--------H---------------------------EE------HHHHEEEEEE---------EEEEE------EEEEE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- WDR33_1C netsurfp ------------E-----HHH---HHHH---EE--H-----EEEE--------EEH-------------------------EEE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ WDR33_1C soprano ---------EEEEEE---------H-H---HHHHH-------EE----------EEE--------H---------------------------E--------HHH-H-------------EEE----------HHH--------------------HHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- WDR33_1C consensus MSEQTPAEAGAAGAREDACRDYQSSLEDLTFNSKPHINMLTILAEENLPFAKEIVSLIEAQTAKAPSSEKLPVMYLMDSIVKNVGREYLTAFTKNLVATFICVFEKVDENTRKSLFKLRSTWDEIFPLKKLYALDVRVNSLDPAWPIKPLPPNVNTSSIHVNPKFLNKSPEEPSTPGTVVSSPSISTPPIVPDIQKNLTQEQLIRQQLLAKQKQLLELQQKKLELELEQAKAQLAVSLSVQQETSNLGPGSAPSKLHVSQIPPMAVKAPHQVPVQSEKSRPGPSLQIQDLKGTNRDPRLNRISQHSHGKDQSHRKEFLMNTLNQSDTKTSKTIPSEKLNSSKQEKSKSGEKITKKELDQLDSKSKSKSKSPSPLKNKLSHTKDLKNQESESMRLSDMNKRDPRLKKHLQDKTDGKDDDVKEKRKTAEKKDKDEHMKSSEHRLAGSRNKIINGIVQKQDTITEESEKQGTKPGRSSTRKRSRSRSPKSRSPIIHSPKRRDRRSPKRRQRSMSPTSTPKAGKIRQSGAKQSHMEEFTPPSREDRNAKRSTKQDIRDPRRMKKTEEERPQETTNQHSTKSGTEPKENVENWQSSKSAKRWKSGWEENKSLQQVDEHSKPPHLRHRESWSSTKGILSPRAPKQQQHRLSVDANLQIPKELTLASKRELLQKTSERLASGEITQDDFLVVVHQIRQLFQYQEGVREEQRSPFNDRFPLKRPRYEDSDKPFVDSPASRFAGLDTNQRLTALAEDRPLFDGPSRPSVARDGPTKMIFEGPNKLSPRIDGPPTPASLRFDGSPGQMGGGGPLRFEGPQGQLGGGCPLRFEGPPGPVGTPLRFEGPIGQAGGGGFRFEGSPGLRFEGSPGGLRFEGPGGQPVGGLRFEGHRGQPVGGLRFEGPHGQPVGGLRFDNPRGQPVGGLRFEGGHGPSGAAIRFDGPHGQPGGGIRFEGPLLQQGVGMRFEGPHGQSVAGLRFEGQHNQLGGNLRFEGPHGQPG PCF11_1N sequence --------------HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------HHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHH-----HHHHHHHH--------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------------------------------------------------------------------------HHHHH-----------------------HHH---------HHHHH-----------------------------HHHH--------------------------HHHHHH-------------------------------------HHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PCF11_1N psipred --------------HHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------EEEEEHHHHH----HHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PCF11_1N prof --------------HHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHHHHHHHH---------EEEEEEHHHH-----HHHHHHHHHHHHHHHHH-----------EEE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PCF11_1N jnet --------------HHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------EEEEEEHHHHH----HHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHH-----HHHHHHHHH-------------------------HH----------------------------HHH--HHHH-HHHHHHHHHHHHH----HHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PCF11_1N sable --------------HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHEHHHHHHHHHH-HHHHHHHHH-HHHHHHHHHH---HHHHHHHHHHHHHHH-------HHHHHHH--------------------------HHHHHHHHH---------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----------------------------------------------HHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PCF11_1N proteus ------HHH-----HHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------HHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHH----HHH--HHHHHH-------------------EEEE-HHHH-----------------------------H---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHH-------HHHHHH---H----------------------EEEEEEE------HHHHH-------------------------------H----------------------E----------HH-----HHHH-------------------HH---------------------HHHH------------------------------------------------------EEE--------HHHHHH-HHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHH-HHHHH--------------------------HHH----------HHHHH-------------------EEEE------------------EEE-----------------------------------------EE-------------E-------E------EEEE---------EEE------------------------------------------------EEEE--------------------------------EEEEEEE--------------------- PCF11_1N sspro4 --------------HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------EEEEEEEE--------HHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PCF11_1N psspred -----H--------HHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHH--HHHHHHHHHHHHH-------------------------------------------------------H---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------------------------------------------------------------------------HHHHH----------------------HHHHHHHHHHHHHHHHHHHHHHHH---------------------HHHHHHHHHHHH---HHHHHHHHH-------HHHHHHHHHHHHHHHHHHHHHHHHHHH-H--------------HHHHHHH-------HHH-H----------------HHHH---HHH------------HHHHHHH-HHHHHHHH---H-HHHHHHHHHHHHHHHHHHHH---HHH-HHHHHHH--------HHHHHHHHHHHHHHHHHH--HHHH--HHH--------------------------------------------HHH-HHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PCF11_1N spineX -----HHHH-----HHHHHHHHHHHH---------HHHHHHHHHHH-HHHHHHHHHHHHHHH-----------------------------HHHHHHHHHHHHHH---------HHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PCF11_1N raptorxss --------------HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHH--HHHHH--HHHH--------------------------H-----------------------------------HHH--HHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HH-----------------------HHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ PCF11_1N SPARROW --------------HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHH-H--------HHHHHHHHH-----HHHHHHHHHHHHHHHHHHHH------HHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PCF11_1N *SPARROW --HHHHHH------HHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------HEEHHHHHHH----EHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHH---HHHHHHHHHHHH-------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PCF11_1N HMMSTR -----HHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHH-HHHHHHHHHHHHHHHHH------HHHHHHHHHHHHH----HHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHH-------EEEEEEE--------------------E----HH----------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----------------------------------------------------------------HHHHH-----------HHH-------------------------------------HHHHHHHH---------------------------------------------------------------------------------------------------HH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHH------------HHHHHHHHHHHHHHHHHHHHHHHH---------------------------HHHH----------HH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PCF11_1N porter -----HHHHH---HHHHHHHHHHHHHHH------HHHHHHHHHHHH-HHHHHHHHHHHHHHH----------HHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHH----HHHHHHHHHH-----------------------------------------------------HHHH-----HHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHH-------------------------------------------------------------------------------HHHH-----------------HHH----------------------HHHH--------------------------------------HHHH--------------HHHH---------HHH--------------------------HHH----------------------------------------HHH-------------------------------HHH-------------HHHH-------------------------------------------------------------------------------------------------------HHHHH------------HHHH-HHHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PCF11_1N spine --------------HHHHHHHHHHHHH-----------EEE--------HHHHHHHHHHHH-----------EEEHHHHHHHH--HHHHHHHHHHHHHEEEEEE-------HHHHHHHHH----------------EE----------------------------------------EE-------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEE--------------------------------------------EEEE--------------------------HHHHHH-----------------------------HHHHHHHHHHHH-----------------------------------------HHHHHHH---------HHHHHHHHHHH-------------------------------------------------------------EE---------------------------------------------------------------HHHHHHHH------------------------------HHHHH--------------------------------------------EE----------HHHHH-HHHHHHHHHHHHH---------EEEHHHHHHHHHHH-------------------------------------------HHHHHHH---------------------EEE------------------EE-------------------------------------------------------------------------EE------------------------EE-----------------------------------EEE-----------EE-------------------------------------EE--------- PCF11_1N nnssp -----HHHHHHHHHHHHHHHHHHHHHHH-------EEEEEEEEE------HHHHHHHHHHHHHH--------HHHHHHHHHHHH-HHHHHHHHH--EEEEEEEEE---HHHHHHHHHHHHHHHHHHHHHHH--------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------------------------------------EEEEEE---------------------HHHHHHHHHHHH------------HHHHHHHHHHHHH------HHHHHHHHHH--------------------------HHHHHHHHHHH-HHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHH----EEEEEEEE------HHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHH------------------------HHHHH----HHHHHHHHHH-------------------EEEE--------------------------------------------------------------------------------------------EEEE----------------------EEEE---------------------EEEEE--------EEEEE--------EEEEEEEEEEEEEEEEEE-----EEEEEEE----------EEEE------- PCF11_1N pssfinder ----------------HHHHHHHHHHH------------HHHHHH--HHHHHHHHHHHHHH-----------EEEEEEEHHHHH----EEHHH------EEEEEE-----HHHHHHHHHH------------EEE------------------------EE----------------EEEE----------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----------------EE---------EEEEEE-------EEEEE-----------HHH---------HHHHHHHH----------------------------------HHHHHH---------------------------HHHHHHH--------HHHHHHH----------HHHH----------HHHHHHHHH-----------EEE-------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH-------EEEEE------------------EE-EEHHHEE-------HHHHHHHHHHHHHH---------EEEEEEHHHHHHHHH--HHH---------------EEE------------EE------HHHHHH---------------------EEEE-----------------EEEE-----------------------------------------EE------------------EEEEE----EEEE-----------------------EEE----------EEE----------EEEE--------EEEE---------EEEE----------EE--------EE-EEE---------EEEE-------- PCF11_1N sspal ------HHHHHHHHHH------------EEEE----HHHHHHHHH---HHHHHHHHHHHHH-----------EEEEEHHHHHH--HHHHHHHHHHEEEEEEEEEHHHHHHHHHHHHHHH----HHHHHHHHH---EEEE-----------------EEEEE----------------EEEE--EEEE-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHEEEEEEEE--------------EEEE--------------------------------------HHHHHHHHH----HHHHHHHHHH-----------------------------HHHHHHHHHHH----------------------------------HHHHHHHHHHHHHHHH--------HHHHHHHHHH---HHHHHHHHHHHH--HHHHHHHHHHHH--------------------------------------------------------------------HHHHHHHHH---HHHHHHHHH---------HHHHHHHHHH------------------------------------HHHHHHHHH---------------------------------EEEE--------HHHHHHHHHHH------------HHHHHHHHHHHHHHHH-----------------------------------------HHHHHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PCF11_1N ssp ---------------HHH-HHHHHHH-------------HHH-HH-------HHHHHHHHHHH------------------------HHHH-------HHHHH----------HHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PCF11_1N sspred --------------HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------HHHHHHHH------HHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PCF11_1N netsurfp ---------------HHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHH-H--------HHHHHHHHHHH------------------------------------------------------------HHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHH--H---------------------------------------------------------------------------------------------------------------H----H------HH------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHH------H----HH--H-------------------HHH---------------------------------------------------------------------------HH---------HHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ PCF11_1N soprano --------------HHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------HHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHH------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H----H--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PCF11_1N consensus MNAAASSYPMASLYVGDLHSDVTEAMLYEKFSPAGPVLSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPIRIMWSQRDPSLRKSGVGNVFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYAFVHFETQEAADKAIEKMNGMLLNDRKVFVGRFKSRKEREAELGAKAKEFTNVYIKNFGEEVDDESLKELFSQFGKTLSVKVMRDPNGKSKGFGFVSYEKHEDANKAVEEMNGKEISGKIIFVGRAQKKVERQAELKRKFEQLKQERISRYQGVNLYIKNLDDTIDDEKLRKEFSPFGSITSAKVMLEDGRSKGFGFVCFSSPEEATKAVTEMNGRIVGSKPLYVALAQRKEERKAHLTNQYMQRVAGMRALPANAILNQFQPAAGGYFVPAVPQAQGRPPYYTPNQLAQMRPNPRWQQGGRPQGFQGMPSAIRQSGPRPTLRHLAPTGSECPDRLAMDFGGAGAAQQGLTDSCQSGGVPTAVQNLAPRAAVAAAAPRAVAPYKYASSVRSPHPAIQPLQAPQPAVHVQGQEPLTASMLAAAPPQEQKQMLGERLFPLIQTMHSNLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHHAKKEAAQKVGAVAAATS PABP-4_1 sequence -----------EEEE--------HHHHHHHH-----EEEEEEEE---------EEEEEE--HHHHHHHHHH--------EEEEEEE-------------EEEE--------HHHHHHHHH----EEEEEEEE------EEEEEEE--HHHHHHHHHHH----------EEEE----HHHHHHHH-------EEEEE-------HHHHHHHHH-----EEEEEEE--------EEEEE---HHHHHHHHHHH---EE--EEEEEE---HHHHHHHHHHHHHHHHHHHHH------EEE---------HHHHHHHH-----EEEEEEEE-----EEEEEEE---HHHHHHHHHHH---EE--EEEEEEE----HHHHHHHHHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHH---HHHHHHHHHHHHHHHHHH-----------------HHHHHHH---HHHHHHHHHHHHHHHHHHHH-HHHHHHH-------- PABP-4_1 psipred -----------EEEE------HHHHHHHHHHH----EEEEEE-----------EEEEE---HHHHHHHHHHH---------EEEEEE---HHH-------EEEE--------HHHHHHHHHH--EEEEEEEE--------EEEE--HHHHHHHHHHHHH--------EEEE-----HHHHHHHHHHHHHH-EEEEE-------HHHHHHHHHH---EEEEEEEE---------EEE----HHHHHHHHHHH--------EEEEE----HHHHHHHHHHHHHHHHHHHHHH----EEEEE-------HHHHHHHH-----EEEEEEEE-------EEEEEE--HHHHHHHHHHHHHHH-----EEEEHHHHHHHHHHHHHHHHHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHH--HHHHHHHHHHHHHHHHHHH-HHH--HHHHHHHH--HHHHHHH---HHHHHHHHHHHHHHHHHHHH---------------- PABP-4_1 prof ------------EE---------HHHHHHHH-----EEEEEEE------------------HHHHHHHHHHH---------EEEE-------------EEEEEE----------HHHHHHHH----EEEEEE-------EEEEEE-HHHHHHHHHHHH---E----EEEE--------------------EEEEEE------HHHHHHHHH-----EEEEEEEE-----------EE---HHHHHHHHHHH--------EEEEE----HHHHHHHHHHHHHHHHHHHHH------EEE--------HHHHHHHH------EEEEEEE-----EEEEEEEE---HHHHHHHHHH---EE----EEEE----HHHHHHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHH----HHHHHHHHHHHHHHHHHH----------------HHHHH------HHHHHHHHHHHHHHHHH------------------ PABP-4_1 jnet -----------EEEE--------HHHHHHHHHH---EEEEEEE----------EEEEE---HHHHHHHHHHH--------EEEEEE-------------EEEEE-------HHHHHHHHHH----EEEEEEE-------EEEEEE--HHHHHHHHHHH---E----EEEEEEE------------------EEEEE-------HHHHHHHHHH---EEEEEEEE--------EEEEEE--HHHHHHHHHHH--------EEEEEE----------------------------EEEEEE-------HHHHHHHHHH---EEEEEEE--------EEEEEE--HHHHHHHHHHH---E----EEEEEEE-------HHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH----HHHHHHHHHHH---HHHH-HHH------EEE----HHHHHHH--HHHHHHHHHHHHHHHHHHH----------------- PABP-4_1 sable -----------EEEEE-------HHHHHHHHHHHEEEEEEEEEEEE---E---EEEEEE---HHHHHHHHHH---E---EEEEEEE------E-----EEEEEE-------HHHHHHHHHHHEEEEEEEEE-E------EEEEEE--HHHHHHHHHHH---EE------EEEE------------------EEEEE-------HHHHHHHHHHH--EEEEEEE-E---EEEEEEEEE---HHHHHHHHHHH--------EEEEEE--------HHHH-----------------EEEEE-------HHHHHHHHHHH--EEEEEEEEE------EEEEEEE-HHHHHHHH-----------EEEEEEE--HHH-HHHHH-HHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHH-----HHHHHHHH-----HHHHH---HHHHHHHHHHHHHHHHHHH----------------- PABP-4_1 proteus -----------EEEE--------HHHHHHHH-----EEEEEEEEE---------EEE----HHHHHHHHHHH--HH-----EEEEE-----HHH-----EEEEE-------HHHHHHHH-----EEEEEEEEE-------EEEE---HHHHHHHHHHH--------EEEEE----HHHHHHHHHHHHHHH--EEE--------HHHHHHHHHH-----EEEEEE-----E--EEEEEE--HHHHHHHHHHH---EE--EE-EEE----HHHHHHHHHHHHHHHHHHHHHHH----EEEE-------HHHHHHHH------EEEEEEE---------EEE---HHHHHHHHHHH---------HHHHHHHHHHHHHHHHHHHHHHHHH--------------------------------------------------------------------------------------------------HH----------------------------------------------------------EEE------HHHHHH---HHHHHHHHHHHHHHHHHHH-HHHHHHHHHHH----HHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHH--------- PABP-4_1 sspro4 ----------EEEEE--------HHHHHHHHHHH--EEEEEEEE---------EEEEEE--HHHHHHHHHHH--EEE--EEEEEEE-------------EEEE--------HHHHHHHHHHH--EEEEEEEE------EEEEEEE--HHHHHHHHHHH--EEE--EEEEEE------HHHHHH--------EEEE--------HHHHHHHHHHH--EEEEEEEE-------EEEEEE---HHHHHHHHHHH--EEE--EEEEEE----HHHHHHHHHHHHHHHH----------EEEE--------HHHHHHHHHH---EEEEEEEE------EEEEEEE--HHHHHHHHHHH--EEE--EEEEEEE---HHHHHHHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHH--HHHHHHHHHHHHHHHHHHH---------HHHH---HHHHHHHH--HHHHHHHHHHHHHHHHHHHH---HHHH--------- PABP-4_1 psspred -----------EEEE--------HHHHHHHHHHH--E-EEEEEE---------EEEEE---HHHHHHHHHHH-------EEEEEEE-------------EEEE--------HHHHHHHHHHH--E-EEEEEEE------EEEEEE--HHHHHHHHHHHH--EE--EEEEE------HHHHHHHHHHH----EEEE--------HHHHHHHHHHH--E-EEEEEE-----E--EEEEE---HHHHHHHHHHHH--EE--EEEEEE----HHHHHHHHHHHHHHHHHHHHH----EEEEEE-------HHHHHHHHHHH-EE-EEEEE--------EEEEE---HHHHHHHHHHHH--EE---EEEEEEE--HHHHHHHHHHHHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHH---HHHH--HHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHH------- PABP-4_1 spineX ----------EEEEE--------HHHHHHHH-----EEEEEE-----------EEEEEE--HHHHHHHHHHH---E----EEEEEE-------------EEEE--------HHHHHHHHH----EEEEEEEE-------EEEEEE--HHHHHHHHHHH---EE---EEEEEEE-----------------EEEEE--------HHHHHHHH-----EEEEEEEE--------EEEEEE--HHHHHHHHHHH--EEE--EEEEEE-----------------------------EEEEE--------HHHHHHHE-----EEEEEEEE-------EEEEEE--HHHHHHHHHHH--EEE---EEEEEEE------------HHHH-----------------------------------------------------------------------------------------------------------------------------HHHH---------------------------------------HHHHHHHH----HHHHH----EE----H------------------HHHHHHHH--HHHHHHHHHHHHHHHHHHH----------------- PABP-4_1 raptorxss ----------EEEEEE-------HHHHHHHHH----EEEEEEEE---------EEEEEE--HHHHHHHHHH----EE---EEEEEE------------EEEEEE---H---HHHHHHHHHH---EEEEEEEE------EEEEEEE--HHHHHHHHHHH---EE--EEEEEEE-E------HH----HH----EEEE-------HHHHHHHHHH---EEEEEEEE------EEEEEEEE--HHHHHHHHHHH---EE--EEEEEE------------------------------EEEEE-------HHHHHHHHH----EEEEEEE--------EEEEEE--HHHHHHHHHHH---EE--EEEEEEEEEE--HHHHHH--HHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHH-------HHHHHHHHH-HHHHHH---------HHHH---HHHHHHHH--HHHHHHHHHHHHHHHHHHHH----HHH--------- PABP-4_1 SPARROW ------------EEEE-------HHHHHHHHH----EEEEEEEE---------EEEEEE--HHHHHHHHHHH--EEE--EEEEEEE--------------EEEE-------HHHHHHHHH----EEEEEEEE-------EEEEE---HHHHHHHHHHH---EE---EEEEEE-------------------EEEEE-------HHHHHHHHHHH--EEEEEEEE--------EEEEE---HHHHHHHHHHH---EE---EEEEEE-------HHHH-----------------EEEEEE-------HHHHHHHHH----EEEEEEEE-------EEEEE---HHHHHHHHHHH---EE---EEEEEEE----HH-HHH--HHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHH------HHHHHHHH-HHHHHH---H--HHHHHH----HHHHHHHH--HHHHHHHHHHHHHHHHHHHH---------------- PABP-4_1 *SPARROW ---------EEEEEEEE------HHHHHHHHHHH--EEEEEEEE------EE--EEEEEE-HHHHHHHHHHH--EEE----EEEEEEE--HHHHH---EEEEEE-HHHHH-HHHHHHHHHHHEEEEEEEEEE------EEEEEEEEEHHHHHHHHHHE---EE---EEEE-----HHHHHHHHHHHHHHHHHEEEE-------HHHHHHHHHHH-EEEEEEEEE-----EE---EEEEE-HHHHHHHHHHH---EE---EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH---EEEEE---H---HHHHHHHHHHHEEEEEEEEEEH-------EEEEEE-HHHHHHHHHHH---EEEE---HHHHHHHHHHHHHHHHHHHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHH-HHHHHHHHHHHHHHHHHHH-HHHH-EEE--EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--HHHHHH------ PABP-4_1 HMMSTR -----------EEEEE-------HHHHHHHHHHH--EEEEEEEE------EEEEEEEEE--HHHHHHHHHHH---EE--EE-EEEE-----HHHH----EEEEE-------HHHHHHHHH----EEEEEE----------EEEEE--HHHHHHHHHH----EE--EEEEEEE-------------------EEEEE-------HHHHHHHHH----EEEEEEEE-----EEEEEEEEE--HHHHHHHHHHH---EE--EEEEEEE-----------------------------EEEEE-------HHHHHHHHH----EEEEEEEE-----EEEEEEEE--HHHHHHHHHHH---E----EEEEEE------------HHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHH----HHHHHHHHHHHHHHHHHHH-HHHHHHHHHHH----HHHHHHHHH-HHHHHHHHHHHHHHHHHH------------------ PABP-4_1 porter -----------EEEEE-------HHHHHHHHH----EEEEEEEE---------EEEEEE--HHHHHHHHHHH---EE---EEEEE--------------EEEEE-------HHHHHHHHHH---EEEEEEEEE-----EEEEEEE--HHHHHHHHHHH--EEE---EEEEE------HHHHHHHHHHH---EEEEE-------HHHHHHHHHHH--EEEEEEEE-------EEEEEEE--HHHHHHHHHHH--EEE---EEEEE------HHHHHHHHHHHHHHHHHH------EEEEE-------HHHHHHHH-----EEEEEEEE------EEEEEEE--HHHHHHHHHHH--EEE--EEEEEEE----HHHHHHHHHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH---HHHHHHHHHHHHHHHHHHH-HHHHH-HHHHHH---HHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--- PABP-4_1 spine HHHHH------EEEE------HHHHHHHHH------EEEEHHHHHHHHH-----EEEE----HHHHHHHHHH----------EEEE--------------EEE---------HHHHHHHHH------EEEEE-------EEEEEE--HHHHHHHHHHHHHHH-----EEEE-----HHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHH-----EEEE-----------EEEE--HHHHHHHHHHHH-------EEEE---HHHHHHHHHHHHHHHHHHHHHHHH-----EEE---------HHHHHHH-------HHHHHHHH------EEEEE--HHHHHHHHHHH---------HHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHH-------------------------HHHHH-------------------------------------------------------HHHHHHHHHH-------------HHHHHHHH--------------------------------------HHHHHH----HHHHHHHHHHHHHHHHHHHH--------EEEE---HHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-- PABP-4_1 nnssp -----------EEEEE-------HHHHHHHHHHH--EEEEEEEE------EEEEEEEEE--HHHHHHHH-------------EEEE-----HHHH----EEEEE-------HHHHHHHHHHH--EEEEEE----------EEEEE--HHHHHHH-----EEEE--EEEEEEE---HHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHH--EEEEEEEE-----EEEEEEEEE--HHHHHHHHHHH--------EEEE-HHHHHHHHHHHHHHHHHHHHHHHHHHH---EEEEE-------HHHHHHHH-----EEEEEEEE----EEEEEEEEE--HHHHHHHHHHH---------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----------------------HHHHHHH---------------------------------------------------------------------HHHHHHHHHHHHHHH----------------------------------------HHHHH---HHH---------HHHHHHH----HHHHHHHHHH--HHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-- PABP-4_1 pssfinder HHHHHH-----EEEE------HHHHHHHHH------EEE--HHHHHH--------EEE------HHHHHHHHHEEEE----EEEEEE-----HHH-----EEE--------HHHHHHHHHH---EEEEEEE----------EEE---HHHHHHHHHHHH--------EEEE-----HHHHHHHHHHHHH--HHHHHHH-----HHHHHHHHHHH-----EEEEE----------EEE---HHHHHHHHHHHH------EEEEE---HHHHHHHHHHHHHHHHHHHHH-HHH--EEEEHHHH-----HHHHHHHH------HHHHHHHHHH-----EEEEE--HHHHHHHHHHH---EE----HHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHH-----------------------HHHHHH--------------------HHHHH-------------------HHHH------HHHH------------HHHHHH-HHHHHHHH------------------------------EE--------HHHHH---HHHHHHHHHHHHHHHHHHHHHHH------HHH---HHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH- PABP-4_1 sspal ------------EEEE--HHHHHHHHH---------EEEEEEEHHHHHHHHH-------HHHHHHHHHHH-----------EEEE---------------EEEEHHHHHHHHHHHHHHHHHH--EEEEEEEE--------HHHHHHHHHHHHHHHHHH--------EEEEHHHHHHHHHHHHH------EEEEEEE---HHHHHHHHHHHHHH---EEEEEEE------------HHHHHHHHHHHHHHHH--------EEEEHHHHHHHHHHHHHHHHHHHHHHHH---------------HHHHHHHHHHHH--------------------EEEEEEE--HHHHHHHHHH--EEEE---HHHHHHHHHHHHHH---HHHHHHHHHHHHH-HHHHHHHHH-----EEEE---------------HHHHHH---------------------------------------------------------------------HHHHHHHHHHHHHHH-----------------------------EEEE--HHHHHHHHHHH--HHHHHHHHHHH--HHHHHHHHHH--EEEEEEEE--HHHHHHHHH-HHHHHHHHHHHHHHHH--HHHHHHHHH-------- PABP-4_1 ssp -----------EEEEE-------HHHHHHHHHH---EEEEEEEEE--------EEEEEE--HHHHHHHHHHH---------EEEE--------------EEEEE-------HHHHHHHHHHH--EEEEEEE-------EEEEEEE--HHHHHHHHHHHH-------EEEEEE--------------------EEEE-------HHHHHHHHHH---EEEEEEEE--------EEEEEE--HHHHHHHHHHH---------EEEE------------------------------EEEEE-------HHHHHHHHHH---EEEEEEE-------EEEEEEE--HHHHHHHHHHH---------EEEEE------------HHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHH-HHHHHHHH------HHHHHHH---HHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHH-HHH------- PABP-4_1 sspred -----------EEEEE-------HHHHHHHHHH---EEEEEEEE---------EEEEE---HHHHHHHHHHH--------EEEEEE-------------EEEEE-------HHHHHHHHHH---EEEEEEEE-------EEEEEE--HHHHHHHHHHH---EE---EEEEEE--------------------EEEE-------HHHHHHHHHH---EEEEEEEE-------EEEEEE---HHHHHHHHHHH---EE---EEEEE---------HHHHHHH--------------EEEE--------HHHHHHHHHH---EEEEEEEE------EEEEEE---HHHHHHHHHHH---EE--EEEEEEE---------HHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH----HHHHHHHHHHHHHHHHHH-----------------HHHHHHH---HHHHHHHHHHHHHHHHHHHH---------------- PABP-4_1 netsurfp -----------EEEE--------HHHHHHHHH----EEEEEE------------EEEE---HHHHHHHHHHH---E----EEEEE--------------EEEE--------HHHHHHHHHH----EEEEEEE--------EEEEE--HHHHHHHHHHH---EE---EEEE-E-E-----------------EEEE--------HHHHHHHHHH---EEEEEEEE--------EEEEEE--HHHHHHHHHHH---EE---EEEE---------HHHHHHHHHHH-----------EEEE--------HHHHHHHHH----EEEEEEE---------EEEEE--HHHHHHHHHHH---EE---EEEEEE-------HHHH-H-HHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH----HHHHHHHHHHHHHHHHHHHHH-------EH-----HHHHHHH--HHHHHHHHHHHHHHHHHHHHHH-HHHH--------- PABP-4_1 soprano -----------EEEE--------HHHHHHHHH----EEEEEEEE---------EEEEEE--HHHHHHHHHHH--------EEEEEE-------------EEEEE-------HHHHHHHHHH---EEEEEEEE-------EEEEEE--HHHHHHHHHHH---EE---EEEEEE-----HHHHHH--------EEEEE-------HHHHHHHHHH---EEEEEEEE--------EEEEEE--HHHHHHHHHHH---EE---EEEEE----HHHHHHHHHHHHHHHHHHH-------EEEEE-------HHHHHHHHH----EEEEEEEE-------EEEEEE--HHHHHHHHHHH---EE---EEEEEE---HHHHHHHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH---HHHHHHHHHHHHHHHHHHH-H--------HHH---HHHHHHHH--HHHHHHHHHHHHHHHHHHHH-H-HHHH--------- PABP-4_1 consensus MSCVHYKFSSKLNYDTVTFDGLHISLCDLKKQIMGREKLKAADCDLQITNAQTKEEYTDDNALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPAMATTKAVCKNTISHFFYTLLLPL RBBP6_3 sequence ---EEEEEE------EEEE------HHHHHHHHHHH---------EEEEE-----------EEEE---EEEEEEEE--------EEEEE----------------------EE----- RBBP6_3 psipred --EEEEEEE------EEEE---EEEHHHHHHHHHHHHH-------EEEE------------EEE----EEEEEEE---------EEEEE-----------------------EEEE-- RBBP6_3 prof ---EEEEEE-------EE------HHHHHHHHHHHH-------EEEEEE------------EEEE---EEEEEEE-------------------------------------EEE--- RBBP6_3 jnet --EEEEEEE------EEEE---EEEHHHHHHHHHHH--------EEEEEE------------EE----EEEEEEE----------EEE------------------------------ RBBP6_3 sable -EEEEEEE----EEEEEEEE-EEE-HHHHHHHHHHHH------EEEEEEE----EEE----EEEE--EEEEEEEEEE-------EEEEE-----------------------EEEE-- RBBP6_3 proteus --EEEEEEE------EEEE------HHHHHHHHHHHH-------EEEEEE------------EEE---EEEEEEE----------EEE--------------------HHHHHH---- RBBP6_3 psspred -EEEEEEEEE----EEEEE------HHHHHHHHHHHH-------EEEEEE-----------EE-----EEEEEEE---------EEEE------------------HHHHHHHHH--- RBBP6_3 spineX --EEEEEE-------EEEE------HHHHHHHHHHH---------EEEE------------EEE----EEEEEE----------EEEEE----------------------------- RBBP6_3 raptorxss --EEEEEEE-----EEEEE------HHHHHHHHHHHH-------EEEEEE-----------EEEE---EEEEEEE---------E-EE-------------------HHHHHHEE--- RBBP6_3 SPARROW --EEEEEE-------EEEE----E-HHHHHHHHHHHH-------EEEEE------EE----EEE----EEEEEE------------EE----------------------HHH----- RBBP6_3 *SPARROW --EEEEEEEE-----EEEEE--EEEEHHHHHHHHHHHH-----EEEEEE------EE-----E-----EEEEEE-----------EEEEE-----------------HHHHHHHHE-H RBBP6_3 HMMSTR -EEEEEEE-----EEEEEE---EEEHHHHHHHHHHHH------EEEEEEE-----EE-----EEE----EEEEEEE---------EEEEE-----------------HHHHHHH---- RBBP6_3 porter ----EEEE------EEEEE----HHHHHHHHHHHHHHHHH----HHHHHHH------------------EEEEE----------EEEEEE---------------------------- RBBP6_3 cdm EEEEEEEE-----EEEEEE---EEEHHHHHHHHHHHH------EEEEEEE-----EE-----EEE----EEEEEEE--------EEEEEE---------------------------- RBBP6_3 fdm EEEEEEEE-----EEEEEE---EEEHHHHHHHHHHHH------EEEEEEE-----EE-----EEE----EEEEEEE----------EEHH----------HHHHHHHHHHHHHHEEEE RBBP6_3 gor -EEEEEEEE------EEEE----EEHHHHHHHHHHH---------EEEE-------------E-----EEEEEEE----------EEEE---------HHHHHHHHHHHHHHHHH--- RBBP6_3 spine --EEEEE---------EEE---EEEE--HHHHHH-----------EEEE--------------------EEEEEE----------EEEEE--------HHHHH-------EEEEEE-- RBBP6_3 nnssp ---------------EEEE--EEEEHHHHHHHHHHHHHHHH----EEEE-------------------EEEEEE------------EEEEE--HHHHHHHHHHHHHHHHHHHHHH--- RBBP6_3 pssfinder EEEEEEEE-------EEEE--EEEEEHHHHHHHH---HHHH----EEEE-------------------EEEEEEE----------EEEEE-----HHHHHHH------HHHHHHH--- RBBP6_3 sspal --EEEEEEE----EEEEEEE-EEEEHHHHHHHHH-----------EEEE--------------------EEEEEEE---EEEEEEEEEEE---------------EEEEEEEEEEE-- RBBP6_3 ssp --EEEEEEE------EEEEE---EEHHHHHHHHHHH--------EEEEEE------------------EEEEEEE----------EEEE------------HHH--HHHHHHHHH--- RBBP6_3 sspred --EEEEEEE------EEEE----E-HHHHHHHHHHH--------EEEEE-------------EE----EEEEEEE----------EEE-------------------------H---- RBBP6_3 netsurfp --EEEEEEE------EEE-------HHHHHHHHHHHH-------EEEEEE------E-----EE----EEEEEEE-----------EEE---------------------HH-HH--- RBBP6_3 soprano --EEEEEEE------EEEE----EEHHHHHHHHHHHH-------EEEEEE------------EE----EEEEEEE----------EEEE---------------------HHHH---- RBBP6_3 consensus MAGLTVRDPAVDRSLRSVFVGNIPYEATEEQLKDIFSEVGPVVSFRLVYDRETGKPKGYGFCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGTGAPVIESPYGETISPEDAPESISKAVASLPPEQMFELMKQMKLCVQNSPQEARNMLLQNPQLAYALLQAQVVMRIVDPEIALKILHRQTNIPTLIAGNPQPVHGAGPGSGSNVSMNQQNPQAPQAQSLGGVPAPGQMPAAVTGPGPGSLAPGGGMQAQVGMPGSGPVSMERGQVPMQDPRAAMQRGSLPANVPTPRGLLGDAPNDPRGGTLLSVTGEVEPRGYLGPPHQGPPMHHVPGHESRGPPPHELRGGPLPEPRPLMAEPRGPMLDQRGPPLDGRGGRDPRGIDARGMEARAMEARGLDARGLEARAMEARAMEARAMEARAMEARAMEVRGMEARGMDTRGPVPGPRGPIPSGMQGPSPINMGAVVPQGSRQVPVMQGTGMQGASIQGGSQPGGFSPGQNQVTPQDHEKAALIMQVLQLTADQIAMLPPEQRQSILILKEQIQKSTGAP CSTF2_2 sequence ----------------EEEEE-------HHHHHHHHHH---EEEEEE-----------EEEEEE--HHHHHHHHHHH--------EEEEE-------HHHHH----------------------HHHHHHHH----HHHHHHHHHHHHHHHHH-HHHHHHHHH----HHHHHHHHHHHHH---HHHHHHHHHH--------------------------------------------------------------------------------------------HHHH-------------------------------------------------------------------------------------------------------------HHHHHH---------HHHHHHHHHHHHHHHHHHHHHHHHHH-----------------------------------------------------------------------------HHHHHHHHHHHHH--HHHHH---HHHHHHHHHHHHHHHHH---- CSTF2_2 psipred ----------------EEEEE-------HHHHHHHHHH---EEEEEEEEE----------EEE---HHHHHHHHHHH--------EEEEE----------------------------------HHHHHHHHH----HHHHHHHHHHHHHH---HHHHHHHHH---HHHHHHHHHHHH-----HHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHH--HHHHH---HHHHHHHHHHHHHHHHH---- CSTF2_2 prof ----------------EEEEE------HHHHHHHHHH------EEEEEE------------E----HHHHHHHHHH---------EEEE-----------------------------------HHHHHHHH-----HHHHHHHHHHHHHH---HHHHHHHHHH----HHHHHHHHH------HHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHH------------HHHHHHHHHHHH------ CSTF2_2 jnet ----------------EEEEE-------HHHHHHHHHH---EEEEEEEE---------EEEEEE--HHHHHHHHHH---------EEEEEE----------------------------------HHHHHH-----HHHHHHHHHHHHHHHH--HHHHHHHHHH---HHHHHHHHHHH-----HHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHH--HHHHHH----HHHHHHHHHHHHH------ CSTF2_2 sable -----------HHHHEEEEEE-------HHHHHHHHHHH---EEEEEEEE----EEE-EEEEEE--HHHHHHHHHHH-------EEEEEEE---HHHHHHHHH----------------------------------HHHHHHHH---------HHHHHHHHHH-----HHHHHHHHHHH----HHHHHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHH----HHHHHH----HHHHHHHHHHHHH------ CSTF2_2 proteus ---------------EEEEEE-------HHHHHHHHHHH--EEEEE--E------E--EEEEEE--HHHHHHHHHHH---E----E-EEE-----------------------------------HHHHHHH----HHHHHHHHHHHHHHH---HHHHHHHHHH-HHHHHHHHHHHHHHHH--HHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------EEEE-----------------------------------------------------------------------------HHHHHHHHH-H-HHHHHHHHHHHHHHHH--------------------------------------------------------------------------------------------HHHHHHHHHHHHH-HHHHH---HHHHHHHHHHHHHHHHH---- CSTF2_2 sspro4 ----------------EEEE--------HHHHHHHHHHH--EEEEEEEE---------EEEEEE--HHHHHHHHHHH---EE--EEEEEE--------HHHHHH--------------------HHHHHHH-----HHHHHHH-----------HHHHHHHHHH-----E---HHHHH-----HHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHH---HHHHHH--HHHHHHHHHHHHHHHHH---- CSTF2_2 psspred ----------------EEEE--------HHHHHHHHHHH--E-EEEEEE---------EEEEEE--HHHHHHHHHHH---EE--EEEEE--HH-HHHHHHHHHH----------------HHHHHHHHHHHHH---HHHHHHHHHHHHHHHH--HHHHHHHHHH-HHHHHHHHHHHHHH----HHHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H--------------HHHHHHHHH--------------------------------------------------------------------------------------------HHHHHHHHHHHH--HHHHHH--HHHHHHHHHHHHHHHHH---- CSTF2_2 spineX ---------HH-----EEEE--------HHHHHHHH-----EEEEEEEE----------EEEEE--HHHHHHHHHHH--------EEEE-----------------------------------------------------------------HHHHHHHH-------E--------------HHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHH----HHHHH---HHHHHHHHHHHHHHH------ CSTF2_2 raptorxss --------HHH----EEEEEE-------HHHHHHHHH----EEEEEEEE---------EEEEEE--HHHHHHHHHH-----E---EEEEE-----------------------------------HHHHHHH----HHHHHHHHHHHHHHHH--HHHHHHHHHH---HHHHHHHHHHH-----HHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHH---HHHHHH--HH---HHHHHHHHHH------ CSTF2_2 SPARROW --------HHH-----EEEEE-------HHHHHHHHHH---EEEEEEEE---------EEEEEE--HHHHHHHHHHH---EE---EEEE----------------------------------------------------HHH-----HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHH------HHHH----HHHHHHHHHHHHHHHH----- CSTF2_2 *SPARROW --------HHHHHHHHEEEEE---HHHHHHHHHHHHHHHEEEEEEEEEE------EE---EEEEE-HHHHHHHHHHH----E---EEEEE----HH-HHHHHHH-----------------H--HHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHEEEE-HHHHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HH--HHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------------------------------------------------------------------------HHHHHHHHHHHHHH--HHHHHH--HHHHHHHHHHHHHHHHH---- CSTF2_2 HMMSTR ----------------EEEEE-------HHHHHHHHH----EEEEEEEE------EEEEEEEEE--HHHHHHHHHHH---E----EEEEEE--------HHH-----------------------HHHHHHH----HHHHHHHHHHHHH-----HHHHHHHHH---HHHHHHHHHHHHH----HHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H--------------------------------------------------------------------------------------------HHHHHHHHHHHHHH---HHHHH---HHHHHHHHHHHHHHH------ CSTF2_2 porter ----------------EEEEE-------HHHHHHHHHH---EEEEEEEE--------EEEEEEE--HHHHHHHHHHH--EEE---EEEE---------HHHH-------------------------EEEEE----HHHHHHHHH--EEEE---HHHHHHHHHH----HEHHHHHHHHH----HHHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------HHHH---------------------------------------HHHHHHHHH-HHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHH-HHHH----------------------------------------------HHHHHH------------------HHHHHHHHHHHHH--HHHHH---HHHHHHHHHHHHHHHH----- CSTF2_2 spine ----------------EEEE--------HHHHHHHHHH----EEEEEEE-----------------HHHHHHHHHH---------EEEE--------HHHHHH------EE-------------------------HHHHHHHHHHHHHH-----HHHHHHHH---HHHHHHHHHHHHHEE---HHHHHHHH-------EE------------------------------------------------------------------------------------------------------------------EEEEE--------------------------------------------------------------------------HHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----------------------------------------------------------------------------HHHHHHHHHHHH---------------EEEHHHHHHH----- CSTF2_2 nnssp ----------------EEEE--------HHHHHHHHHHH--EEEEEEEEE--------EEEEEE--HHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHH--------------------HHHHHHHHHH--HHHHHHHHHHHHHHH---HHHHHHHHHH-HHHHHHHHHHHHHHHH--HHHHHHHHHHH----EEEE----------------------------------------------------------------------------------HHHHHHH------------------------EEEEE--------------------------------------------------------------------------HHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------------------------------------------------------------------HHHHHHHHHHHHHHH--HHHHHH--HHHHHHHHHHHHHHHH----- CSTF2_2 pssfinder -----------------EEE-----HHHHHHHHHHHHH---EEEEEE-------------------HHHHHHHHHH---------EE---------HHHHHH-------EE--------------HHHHHHH----HHHHHHHHHH-HHHH----HHHHH------HHHHHHHHHHHHHH---HHHHHHHHH---------------------------------------------------------------------EEEE--------------------------------------------------EEEEEEE---------------------------------------------------------------------------HHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------------------------------------------EE------------------------------HHHHHHHHHHHHHHHHHHHH--------HHHHHHHHHHH----- CSTF2_2 sspal ---EEEE------EEEEEEE-----HHHHHHHHHHHHHH--EEEEEEEE-------------HHHHHHHHHHHHH--------------HHHHHHHHHHHHHHH-------------------HHHHHHHHHH----HHHHHHHHHEEEEEEE--HHHHHHHHH--HHHHHHHHH-EEEEEEE-HHHHHHHHH-------------------------------------------------------------------EEEEEEE------------------------------------------------EEEEEEEEEE---------------------------------------------------------------------HHHHHHHHHHHH---HHHHHHHHHHHHH--HHHHHHHHHHHHH---------------------------------EEEEEEE------EEEE-------------------------------HHHHHHHHHHHH-HHHHHHH--HHHHHHHHHHHHHHH----- CSTF2_2 ssp ----------------EEEEE-------HHHHHHHHHH---EE-EEEE-----------EEEEE--HHHHHHHHHHH---EE----EEEE-------------------------------------------------HHHH----EEEE---HHHHHHHHH-----EEEE-EHHH------HHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHH-----HHH------HH-HH-HHHHHH------ CSTF2_2 sspred ----------------EEEEE-------HHHHHHHHHH----EEEEEE-----------EEEE---HHHHHHHHHHH----E---EEEE----------HHH---------------------HHHHHHH-------HHHHHHHHHHHHH----HHHHHHHHHHH--HHHHHHHHHHH-----HHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHH---HHHH--------HHHHHHHHHH------- CSTF2_2 netsurfp ----------------EEEE--------HHHHHHHHHH----EEEEEEE----------EEEE---HHHHHHHHHHH--------EEEE----------------------------------HHHHHHHH-----HHHHHHHHHHHHHHHH--HHHHHHHHHH---HHHHHHHHHHHH----HHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHH--HHHHHH--HHHHHHHHHHHHHHHHH---- CSTF2_2 soprano ----------------EEEEE-------HHHHHHHHHH---EEEEEEEE---------EEEEEE--HHHHHHHHHHH--------EEEEE---------HHH-----------------------HHHHHHH----HHHHHHHHHHHHHHH---HHHHHHHHHH---HHHHHHHHHHHH----HHHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHH--HHHHH---HHHHHHHHHHHHHHHH----- CSTF2_2 consensus MATPASAPDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQAMRAAGDEFETRFRRTFSDLAAQLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVGQVQEWMVAYLETQLADWIHSSGGWELEAIKARVREMEEEAEKLKELQNEVEKQMNMSPPPGNAGPVIMSIEEKMEADARSIYVGNVDYGATAEELEAHFHGCGSVNRVTILCDKFSGHPKGFAYIEFSDKESVRTSLALDESLFRGRQIKVIPKRTNRPGISTTDRGFPRARYRARTTNYNSSRSRFYSGFNSRPRGRVYRGRARATSWYSPY PABP-2_3 sequence ---------HHHHHHHHHHHHHH-----------------HHHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHH-------EEEEEEEHHHHHHHHHHH-------HHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----------------HHHHH------EEEE-------HHHHHHHH-----EEEEEEE----------EEEEEE--HHHHHHHHH-----------EEE------------------------------------------------------------- PABP-2_3 psipred ---------HHHHHHHHHHHHH----------------HHHHHHHHHH--HHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHH----HHHHEEHHHHHHHHHHHH----------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------------HHHHH-----EEEEEEE-----HHHHHHHHH----EEEEEEEEE--------EEEEEE--HHHHHHHHH---------EEEEE------------------------------------------------------------- PABP-2_3 prof --------HHHHHHHHHHHHH------------------HHHHHHHHH----HHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHH------EEEEEE----------------------------------------------------------------HHHHH----------------------------EEEEEE-------HHHHHHHH-----EEEEEEEE---------EEEEEE-----HHHHEE---------EEEEE------------------------------------------------------------- PABP-2_3 jnet ---------HHHHHHHHHHHHH-----------------HHHHHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHH------EEEEEEEE--EEEEEE-----HHHHHHHHHH--------------------------------------------------------------------------EEEEE-------HHHHHHHHHH---EEEEEEEE---------EEEEE---HHHHHHHHH---------EEEEE------------------------------------------------------------- PABP-2_3 sable --------HHHHHHHHHHHHHHHH-----------------HHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHH-------HHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHH-HHHHHHH--HHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------------------------EEEEEE-------HHHHHHHHHH---EEEEEEEEE----EEE-EEEEEE--HHHHHHHHHHH------EEEEEE------------------------------------------------------------- PABP-2_3 proteus ----------HHHHHHHHHHHHH----------------HHHHHHHHHH-HHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHH------HEEHEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHH--HHHHHHHHHHHHHHHHHHHHH----------------HHHHH-----EEEE--------HHHHHHHH-----EEEEEEE----------EEEEE---HHHHHHHHHH-HHH----EEEEE----------------------------------E------------E------------- PABP-2_3 sspro4 -------HHHHHHHHHHHHHHHH---------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHH---HHHEEEEEEEHHHEEHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------------HHHH------EEEEE-------HHHHHHHHHH---EEEEEEEE--------EEEEEEE--HHHHHHHHHH---EE--EEEEEEE------------------------------------------------------------ PABP-2_3 psspred --------HHHHHHHHHHHHHHHHH-------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------------HHHHH-----EEEE--------HHHHHHHHHH---E-EEEEEE---------EEEEEE--HHHHHHHHHH---EE---EEEEE------------------------------------------------------------- PABP-2_3 spineX ---------HHHHHHHHHHHH-------------------HHHHHHHHH---HHHHHHHHHHHHHHH-------HHHHHH---HHHH-------HHHHHHEE-----HH--------------EEEEEEE------------EEEEEEEEEEEEEEEEEEEEEEEEEEEEEE--------------------------EEEEE--------HHHHHHHH-----EEEEEEE-----------EEEEE--HHHHHHHHH---------EEEEE------------------------------------------------------------- PABP-2_3 raptorxss ---------HHHHHHHHHHHHHHH----------------HHHHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHH----HHHHHEHHHHHHHHHHHHH------HHHHHHHHHHH--HHHHHHHHHHH-----HHHHHHHHH------HHHH---HHHHH----------------HHHHHH----EEEEE-------HHHHHHHHHH--EEEEEEEEE---------EEEEEE--HHHHHHHHHH---HH---EEEEE------------------------------------------------------------- PABP-2_3 SPARROW --------HHHHHHHHHHHHHHHH---------------HHHHHHHHHHHHHHHHH-HHHHHHHHHH----HHHHHHHHHHHHHHHHH-----H-EEEEEEEE----HHHH-----HHH--------HHHHH-----------------HHHHHHHH----HHHHHHHHHHHH--------------------------EEEEE-------HHHHHHHHH----EEEEEEEE---------EEEEE---HHHHHHHHHH---EE--EEEEEE------------------------------------------------------------- PABP-2_3 *SPARROW ----HHHHHHHHHHHHHHHHHHHH--------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE-HHHHHHHHHHHHHHHHH------EEEEEEEE--EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------------HHHHHH--EEEEEEE-E-----HHHHHHHHHH----EEEEEEEE---------EEEEEEEHHHHHHHHHH-HHHH---EEEEEE------------------------------------------------------------ PABP-2_3 HMMSTR ---------HHHHHHHHHHHHHHH----------------HHHHHHHHHHHHHHHH--HHHHHHHHH-------HHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHH-HHHHHHH---HHHHHH--HH----HHHHHHHHHH----HHH--------------------H-HHHEEEEE-------HHHHHHHHHHH--EEEEEEEE--------EEEEEEE--HHHHHHHHHH---EE--EE-EEEE------------------------------------------------------------ PABP-2_3 porter --------HHHHHHHHHHHHHHH----------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHH----------------HHHHH-----EEEEE-------HHHHHHHHHH---EEEEEEEEE------EEEEEEEE--HHHHHHHHHH---EE--EEEEEE------------------------------------------------------------- PABP-2_3 spine ---------HHHHHHHHH--------EEE-----------HHHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHH---------EEEEE--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----------HHHHHHHHHHH---EEEEE-------HHHHHHHH-------EEEEE-----------EEEE------HHHHHHH---------EEE-------------------HHHHH-----------------------EE------------- PABP-2_3 nnssp ---------HHHHHHHHHHHHHHH--------HHH-------HHHHHHHHHHHHHH----HHHHHHH--------HHHHHHHHHHH------HHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHH-HHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------------HHHHHHHHH-EEEE--------HHHHHHHH-------EEEEEEE--------EEEEEE--HHHHHHHHHHHHHHH---EEEEEE------------------------------------------------------------ PABP-2_3 pssfinder ---------HHHHHHHHH--EE----EEEE----------HHHHHHHHH-HHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHH--------EEEEEEE-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----------EEEHHHHHHH----EEEEE-------HHHHHHHH-------EEEEEE---------EEEEEE----HHHHHHHHHHHHH---EEEEE--------------------EE----------EEEE----------EEE------------ PABP-2_3 sspal ---------HHHHHHHHH--------EEEE---------HHHHHHHHHH--HHHHHHHHHHHHHHHHEEEE---HHHHHHHHHHHHHH-------EEEEEEE-HHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------------HHHHHHHHHH--EEEEE------HHHHHHHHH--------EEEEEEE--------EEEEEEE----EEEEEEE-------EEEEEEE------------------------------------------------------------ PABP-2_3 ssp ---------HHHHHHHHHHHHHHH---------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHH------HHEEEEHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHH------HH---------------------HHH---------------------------EEEEEEE-----HHHHHHHHHH---EEEEEEE---------EEEEEEE--HHHHHHHHHH---EE--EEEEEEE------------------------------------------------------------ PABP-2_3 sspred -------HHHHHHHHHHHHHHH-----------------HHHHHHHHHHHHHHHHHHHHHHHHHH--------HHHHHHHHHHHHHHH------------EEE--------HHHHHHHH-----HHHHHHH-----HH-----------------------HH-HHH-HHHHH---------------------------EEE--------HHHHHHHHHH---EEEEEEE----------EEEEEE--HHHHHHHHHH--------EEEEE------------------------------------------------------------- PABP-2_3 netsurfp ---------HHHHHHHHHHHHHHH--------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHH----HHHHHHHHEEHHHHHHHHHHH---HHHHHHHHHHHHHHH----HHHHH--------------------------HHHHHH---------------------------EEEEE-------HHHHHHHHHH----EEEEEEE----------EEEEE--HHHHHHHHH-----E---EEEEE------------------------------------------------------------- PABP-2_3 soprano ---------HHHHHHHHHHHHHH----------------HHHHHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHH-----HHEEE-HEHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHH----------------HHHHH-----EEEEE-------HHHHHHHHHH---EEEEEEEE---------EEEEEE--HHHHHHHHHH--------EEEEE------------------------------------------------------------- PABP-2_3 consensus MNAAASSYPMASLYVGDLHSDVTEAMLYEKFSPAGPVLSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPIRIMWSQRDPSLRKSGVGNVFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYAFVHFETQEAADKAIEKMNGMLLNDRKVFVGRFKSRKEREAELGAKAKEFTNVYIKNFGEEVDDESLKELFSQFGKTLSVKVMRDPNGKSKGFGFVSYEKHEDANKAVEEMNGKEISGKIIFVGRAQKKVERQAELKRKFEQLKQERISRYQGVNLYIKNLDDTIDDEKLRKEFSPFGSITSAKVMLEDGRSKGFGFVCFSSPEEATKAVTEMNGRIVGSKPLYVALAQRKEERKAHLTNQYMQRVAGMRALPANAILNQFQPAAGGYFVPAVPQAQGRPPYYTPNQLAQMRPNPRWQQGGRPQGFQGMPSAIRQSGPRPTLRHLAPTGNAPASRGLPTTTQRVGVPTAVQNLAPRAAVAAAAPRAVAPYKYASSVRSPHPAIQPLQAPQPAVHVQGQEPLTASMLAAAPPQEQKQMLGERLFPLIQTMHSNLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHHAKKEAAQKVGAVAAATS PABP-4_2 sequence -----------EEEE--------HHHHHHHH-----EEEEEEEE---------EEEEEE--HHHHHHHHHH--------EEEEEEE--------------EEE--------HHHHHHHHH----EEEEEEEE------EEEEEEE--HHHHHHHHHHH-----------EEE-----HHHHHHHH------EEEEE-------HHHHHHHHHH----EEEEEEE--------EEEEE---HHHHHHHHHHH---EE--EEEEEE----HHHHHHHHHHHHHHHHHHHH------EEEEE-------HHHHHHHH-----EEEEEEEE------EEEEEE---HHHHHHHHHHH---EE--EEEEEEE----HHHHHHHHHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHH---HHHHHHHHHHHHHHHHH------------------HHHHHHH---HHHHHHHHHHHHHHHHHHHH-HHHHHHH-------- PABP-4_2 psipred -----------EEEE------HHHHHHHHHHH----EEEEEE-----------EEEEE---HHHHHHHHHHH---------EEEEEE-------------EEEE--------HHHHHHHHHH--EEEEEEEE-------EEEEE--HHHHHHHHHHHHH--------EEEE-----HHHHHHHHHHHHH---EEEE-------HHHHHHHHHH---EEEEEEEE---------EEE----HHHHHHHHHHH--------EEEEE----HHHHHHHHHHHHHHHHHHHHHH----EEEEE-------HHHHHHHH-----EEEEEEEE-------EEEEEE--HHHHHHHHHHHHHHH-----EEEEEHHHHHHHHHHHHHHHHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHH--HHHHHHHHHHHHHHHHHHH-HHH--HHHHHHHH--HHHHHHH---HHHHHHHHHHHHHHHHHHHH---------------- PABP-4_2 prof -----------EEEE----------HHHHHH-----EEEEEEE------------------HHHHHHHHHHH---------EEEEE------------EEEEEE---------HHHHHHH------EEEEEE-------EEEEEE-HHHHHHHHHHHH---EE---EEEE-------------------EEEEEEE-----HHHHHHHHHH-----EEEEEEEE--------EEEEE---HHHHHHHHHHH--------EEEEE----HHHHHHHHHHHHHHHHHHHHHH-----EEE--------HHHHHHHH------EEEEEEE-----EEEEEEEE---HHHHHHHHHHHHHHHH---EEEEE---HHHHHHHHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHH----HHHHHHHHHHHHHHHHHH------------E-----EEEEEE---HHHHHHHHHHHHHHHHH------------------ PABP-4_2 jnet -----------EEEE--------HHHHHHHHHH---EEEEEEE----------EEEEE---HHHHHHHHHH---------EEEEEE-------------EEEEE-------HHHHHHHHHH---EEEEEEEE-------EEEEE---HHHHHHHHHHH---E----EEEEEEE------------------EEEEE-------HHHHHHHHHH---EEEEEEEE--------EEEEEE--HHHHHHHHHH---------EEEEEE-----------HH---------------EEEEEE-------HHHHHHHHHH---EEEEEEE---------EEEEE--HHHHHHHHHHH---E----EEEEEE-------HHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH----HHHHHHHHHHHHHHHHHHHHHH-------E-----HHHHHHH--HHHHHHHHHHHHHHHHHH------------------ PABP-4_2 sable -----------EEEEE-------HHHHHHHHHHHEEEEEEEEEEEE---E---EEEEEE---HHHHHHHHHH--EE---EEEEEEE------E-----EEEEEE-------HHHHHHHHHHHEEEEEEEEE-E------EEEEEE--HHHHHHHHHHH----------EEEEE-----------------EEEEEE-------HHHHHHHHH----EEEEEEEEE---EEEEEEEEEE--HHHHHHHHHHH-------EEEEEEE---------HHH-----------------EEEEE-------HHHHHHHHHHH--EEEEEEEEE------EEEEEEE-HHHHHHHHH----------EEEEEEE--HHH-HHHHH-HHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHH-------HHHHHHH---HHHHHHH---HHHHHHHHHHHHHHHHHHHH---------------- PABP-4_2 proteus -----------EEEE--------HHHHHHHH-----EEEEEEEEE---------EEE----HHHHHHHHHHH---H-----EEEEE-----HHH-----EEEEE-------HHHHHHHHHH---EEEEEEEE---------EEE---HHHHHHHHHHH---------EEEE----HHHHHHHHHHHHHH---EEEE-------HHHHHHHH------EEEEEEE-----E--EEEEEE--HHHHHHHHHHH---EE--EE-EEE----HHHHHHHHHHHHHHHHHHHHHHH----EEEE-------HHHHHHHH------EEEEEEE---------EEE---HHHHHHHHHHH---------HHHHHHHHHHHHHHHHHHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------EE----HHHHHHHH---HHHHHHHHHHHHHHHHHHH-HHHHHHHHHHH----HHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHH-------- PABP-4_2 sspro4 -----------EEEE--------HHHHHHHHHHH--EEEEEEEE---------EEEEEE--HHHHHHHHHHH--EEE--EEEEEEE-------------EEEE--------HHHHHHHHHHH--EEEEEEEE------EEEEEEE--HHHHHHHHHHH--EEE--EEEEEE------HHHHHHH-------EEEE--------HHHHHHHHHHH--EEEEEEEE-------EEEEEE---HHHHHHHHHHH--EEE--EEEEEE-----HHHHHHHHHHHHHH-----------EEEE--------HHHHHHHHHH---EEEEEEEE------EEEEEEE--HHHHHHHHHHH--EEE--EEEEEEE---HHHHHHHHHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHH--HHHHHHHHHHHHHHHHHHH-------HHHHHH---HHHHHHHH--HHHHHHHHHHHHHHHHHHHHH--HHH---------- PABP-4_2 psspred ----------EEEEE--------HHHHHHHHHHH----EEEEEE---------EEEEE---HHHHHHHHHHH-------EEEEEEE-------------EEEE--------HHHHHHHHHHH--E-EEEEEEE------EEEEEE--HHHHHHHHHHHH--E----EEEEE-----HHHHHHHHHHH----EEEE--------HHHHHHHHHHH--E-EEEEEE--------EEEEE---HHHHHHHHHHH---EE--EEEEEE----HHHHHHHHHHHHHHHHHHHHH----EEEEEE-------HHHHHHHHHHH-EE-EEEEE--------EEEEE---HHHHHHHHHHHH-EEE---EEEEEE---HHHHHHHHHHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHH--HHHHHHHHHHHHHHHHHHH--HHHH----HHHH--HHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHH------- PABP-4_2 spineX ----------EEEEE--------HHHHHHHH-----EEEEEE-----------EEEEEE--HHHHHHHHHH---------EEEEEE-------------EEEE--------HHHHHHHHHH---EEEEEEEE-------EEEEEE--HHHHHHHHHHH---EE---EEEEEEE-----------------EEEEE--------HHHHHHHH-----EEEEEEEE--------EEEEEE--HHHHHHHHHH---EEE--EEEEEE-----------------------------EEEEE--------HHHHHHHE-----EEEEEEE--------EEEEEE--HHHHHHHHHH---EEE---EEEEEEE--------------HH----------------------------------------------------------------------------------------------------------------HHHH------------------------------------------HHHHH---HHHHHHH--------HH------------------HHHHHHHHH-HHHHHHHHHHHHHHHHHHH-------HH-------- PABP-4_2 raptorxss -----------EEEEE-------HHHHHHHHH----EEEEEEEE---------EEEEEE--HHHHHHHHHHH---EE---EEEEEEE------------EEEEE---H---HHHHHHHHHH---EEEEEEEE------EEEEEEE--HHHHHHHHHHH---EE--EEEEEEE--------HH---------EEEEE-------HHHHHHHHHH---EEEEEEEE------EEEEEEEE--HHHHHHHHHHH---EE--EEEEEE-----------HHHH---------------EEEEE-------HHHHHHHHH----EEEEEEE--------EEEEEE--HHHHHHHHHHH---EE--EEEEEEEE-E--HHHHH---HHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------HHHH--------HHH---H-HHHHHHH-HHH-----HHHH---HHHHHHHH--HHHHHHHHHHHHHHHHHHHH-HHHHHHH-------- PABP-4_2 SPARROW ------------EEEE-------HHHHHHHHH----EEEEEEE----------EEEEEE--HHHHHHHHHHH---EE---EEEEEEE------------EEEEE-------HHHHHHHHH----EEEEEEEE-------EEEEEE--HHHHHHHHHHH---EE---EEEEEE-------------------EEEE--------HHHHHHHHHHH--EEEEEEEE--------EEEEE---HHHHHHHHHHH--EEE---EEEEEE--------HHH-----------------EEEEEE-------HHHHHHHHH----EEEEEEEE-------EEEEEE--HHHHHHHHHHH--EEE---EEEEEEEE--HHHHHHH--HHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH---HHH--HHHHHHHHHHHHHH--HH--HHHHH-----HHHHHHHH--HHHHHHHHHHHHHHHHHHHH---------------- PABP-4_2 *SPARROW ---------EEEEEEEE------HHHHHHHHHHH--EEEEEEEE------EE--EEEEEE-HHHHHHHHHHH--EEE----EEEEEEE--HHHHH---EEEEEE-HHHHH-HHHHHHHHHHHEEEEEEEEEE------EEEEEEEEEHHHHHHHHHHE---EE---EEEE-----HHHHHHHHHHHHHHHHHEEEE-------HHHHHHHHHHH-EEEEEEEEE-----EE---EEEEE-HHHHHHHHHHH---EE---EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH---EEEEE---H---HHHHHHHHHHHEEEEEEEEEEH-------EEEEEE-HHHHHHHHHHH---EEEE---HHHHHHHHHHHHHHHHHHHHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHH-HHHHHHHHHHHHHHHHHHH-HHHH--EE--EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--HHHHHHHH---H PABP-4_2 HMMSTR -----------EEEEE-------HHHHHHHHHHH--EEEEEEEE------EEEEEEEEE--HHHHHHHHHHH---EE--EE-EEEE-----HHHH----EEEEE-------HHHHHHHHH----EEEEEE--E-------EEEEE--HHHHHHHHHH----EE--EEEEEEE-------------------EEEEE-------HHHHHHHHH----EEEEEEEE-----EEEEEEEEE--HHHHHHHHHHH---EE--EEEEEEE-----------------------------EEEEE-------HHHHHHHHH----EEEEEEEE-----EEEEEEEE--HHHHHHHHHHH---E----EEEEEE------------HHH----------------------------------------------------------------------------------------------------------------------------------------------------------------HHHH--------HHHHHHHHHHHHHHH-HHHHHHHHHHH----HHHHHHHH--HHHHHHHHHHHHHHHHHH------------------ PABP-4_2 porter -----------EEEE--------HHHHHHHH------EEEEEEE---------EEEEEE--HHHHHHHHHHH---------EEEEE-------------EEEE--------HHHHHHHHH-----EEEEEEE-------EEEEEE--HHHHHHHHHHH---------EEEEE-------------------EEEE--------HHHHHHHH------EEEEEEE--------EEEEEE--HHHHHHHHHHH---------EEEEE-------HHHHHHHH-------------EEEEEE-------HHHHHHHH-----EEEEEEEE-------EEEEEE--HHHHHHHHHHH---------EEEEE--------HHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHH-----------------HHHHHHHH--HHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHH-------- PABP-4_2 cdm -----------EEEEE-------HHHHHHHHHHH--EEEEEEEE------EEEEEEEEE--HHHHHHHHHH----EE--EE-EEEE-------------EEEEE-------HHHHHHHH-----EEEEEEE--------EEEEEE--HHHHHHHHHHH---EE--EE-EEEE-------------------EEEE--------HHHHHHHH------EEEEEEE--------EEEEEE--HHHHHHHHHHH---------EEEEE-------HHHHHHHH--------------EEEEE-------HHHHHHHH-----EEEEEEEE----EEEEEEEEE--HHHHHHHHHHH----------EEEE---------HHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHH--HHHHHHHHHHHHHHHHHHH----HHHHHHHH----HHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHH-------- PABP-4_2 fdm -----------EEEEE-------HHHHHHHHHHH--EEEEEEEE------EEEEEEEEE--HHHHHHHHHH----EE--EE-EEEE-------------EEEEE-------HHHHHHHH-----EEEEEEE--------EEEEEE--HHHHHHHHHHH---EE--EE-EEEE-------------------EEEEE-------HHHHHHHHH----EEEEEEEE--------EEEEEE--HHHHHHHHHHH---EE--EE-EEEE-----------------------------EEEEE-------HHHHHHHH-----EEEEEEEE----EEEEEEEEE--HHHHHHHHHHH----------EEEE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHH--HHHHHHHHHHHHHHHHHHH----HHHHHHHH----HHHHHHHHH-HHHHHHHHHHHHHHH--------------------- PABP-4_2 gor -----------EEEEE-------HHHHHHHHH----EEEEEEEE-------E-EEEEEE--HHHHHHHHHHH---EE---EEEEE--------------EEEEE-------HHHHHHHHHH---EEEEEEEEE-----EEEEEEE--HHHHHHHHHHH--EEE---EEEEE------HHHHHHHHHHH---EEEEE-------HHHHHHHHHHH--EEEEEEEE-------EEEEEEE--HHHHHHHHHHH--EEE---EEEEE------HHHHHHHHHHHHHHHHHH------EEEEE-------HHHHHHHH-----EEEEEEE-------EEEEEEE--HHHHHHHHHHH--EEE---EEEEEE----HHHHHHHHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH---HHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHH---HHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--- PABP-4_2 spine HHHHH------EEEE------HHHHHHHHH------EEEEHHHHHHHHH-----EEEE----HHHHHHHHHH---------EEEEE--------------EEE--------HHHHHHHHHH------EEEEE-------EEEEEE--HHHHHHHHHHHHHHH-----EEEE-----HHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHH-----EEEE-----------EEEE--HHHHHHHHHHHH------EEEEE---HHHHHHHHHHHHHHHHHHHHHHHH-----EEE---------HHHHHHH-------HHHHHHHH------EEEEE--HHHHHHHHHHH---------HHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHH--------EE---------------HHHHH-----------------------------------------------------------------HHHHHHHH--------------------------------------HHHHHH----HHHHHHHHHHHHHHHHHHHH--------EEEE---HHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH- PABP-4_2 nnssp -----------EEEEE-------HHHHHHHHHHH--EEEEEEEE------EEEEEEEEE--HHHHHHHH-------------EEEE-----HHHH----EEEEE-------HHHHHHHHHHH--EEEEEE----------EEEEE--HHHHHHH-----EEEE--EEEEEEE---HHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHH--EEEEEEEE-----EEEEEEEEE--HHHHHHHHHHH--------EEEE-HHHHHHHHHHHHHHHHHHHHHHHHHHH---EEEEE-------HHHHHHHH-----EEEEEEEE----EEEEEEEEE--HHHHHHHHHHH---------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----------------------HHHHHHH--------------------------------------------------------HHHHHHHHHHHHHHH----------------------------------------HHHHH---HHH---------HHHHHHH----HHHHHHHHHH--HHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-- PABP-4_2 pssfinder HHHHHH-----EEEE------HHHHHHHHH------EEEHHHHHHHH--------EE-----HHHHHHHHHHHHEEE----EEEEEEE----HHH-----EEEHHHHH---HHHHHHHHHHH-----EEEE---------EEEE---HHHHHHHHHHHH--------EEEE----HHHHHHHHHHHHHHH-HHHHHHH-----HHHHHHHHHHHH----EEEEE-------------HHHHHHHHHHHHHHH------EEEEE---HHHHHHHHHHHHHHHHHHHHHHHH---EEEHHHHH-----HHHHHHHH----EE-HHHHHHHH-----EEEEEE--HHHHHHHHHHH---EE----HHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHH-------EE--------------HHHHHH---------------------HHHH-------EE-----------------------HHHHHH-HHHHHHHH------------------------------EE--------HHHHH---HHHHHHHHHHHHHHHHHHHHHHH-------EEE---HHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH- PABP-4_2 sspal ------------EEEE--HHHHHHHHH---------EEEEEEEHHHHHHHHH-------HHHHHHHHHHH-----------EEEE---------------EEEEHHHHHHHHHHHHHHHHHH--EEEEEEEE--------HHHHHHHHHHHHHHHHHH--------EEEEHHHHHHHHHHHHH------EEEEEEE---HHHHHHHHHHHHHH---EEEEEEE------------HHHHHHHHHHHHHHHH--------EEEEHHHHHHHHHHHHHHHHHHHHHHHH---------------HHHHHHHHHHHH--------------------EEEEEEE--HHHHHHHHHH--EEEE---HHHHHHHHHHHHHH---HHHHHHHHHHHHH-HHHHHHHHH-----EEEE---------------HHHHHH--------------------------------------------------------HHHHHHHHHHHHHHH-----------------------------EEEE--HHHHHHHHHHH--HHHHHHHHHHH--HHHHHHHHHH--EEEEEEEE--HHHHHHHHH-HHHHHHHHHHHHHHHH--HHHHHHHHH-------- PABP-4_2 ssp -----------EEEEE-------HHHHHHHHHH---EEEEEEE----------EEEEEE--HHHHHHHHHHH---------EEEE--------------EEEEE-------HHHHHHHHHHH--EEEEEEE-------EEEEEEE--HHHHHHHHHHHH-EE----EEEEEE--------------------EEEE-------HHHHHHHHHH---EEEEEEEE--------EEEEEE--HHHHHHHHHHH---------EEEE-----------HH-----------------EEEEE-------HHHHHHHHHH--EE-EEEEE-------EEEEEEE--HHHHHHHHHHHH--------EEEEE------------HHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHH----------H-H-----HHHHHHHH--HHHHHHHHHHHHHHHHHHHHHH-HH-HHH------- PABP-4_2 sspred -----------EEEE--------HHHHHHHHHH---EEEEEEEE---------EEEEEE--HHHHHHHHHHH--------EEEEEE-------------EEEEE-------HHHHHHHHHH---EEEEEEEE-------EEEEEE--HHHHHHHHHHH---EE---EEEEEE-------------------EEEEE-------HHHHHHHHHH---EEEEEEEE-------EEEEEE---HHHHHHHHHHH---EE---EEEEE------------------------------EEEE--------HHHHHHHHHH---EEEEEEEE------EEEEEEE--HHHHHHHHHHH---EE---EEEEEE-------------HHH--------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH----HHHHHHH------HHHHH-----------------HHHHHHH---HHHHHHHHHHHHHHHHHHHH---------------- PABP-4_2 netsurfp -----------EEEE--------HHHHHHHHH----EEEEEEE-----------EEEE---HHHHHHHHHHH---E----EEEEEE-------------EEEE--------HHHHHHHHHH----EEEEEEE--------EEEEE--HHHHHHHHHHH---EE---EEEE-E-------------------EEEE--------HHHHHHHHHH---EEEEEEEE--------EEEEEE--HHHHHHHHHHH---EE---EEEE----------HHHHHHHHHH-----------EEEE--------HHHHHHHHH----EEEEEEE---------EEEEE--HHHHHHHHHHH---EE---EEEEEE--------HH--HHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH----HHHHHHHHHHHHHHHHHH----------EE-----HHHHHHH--HHHHHHHHHHHHHHHHHHHHHH---HH--------- PABP-4_2 soprano -----------EEEE--------HHHHHHHHH----EEEEEEEE---------EEEEEE--HHHHHHHHHHH--------EEEEEE-------------EEEEE-------HHHHHHHHHH---EEEEEEEE-------EEEEEE--HHHHHHHHHHH---EE---EEEEEE--------HH---------EEEEE-------HHHHHHHHHH---EEEEEEEE--------EEEEEE--HHHHHHHHHHH---EE---EEEEE------HHHHHHHHHHHHH-----------EEEEE-------HHHHHHHH-----EEEEEEEE-------EEEEEE--HHHHHHHHHHH---EE---EEEEEE----HHHHHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH---HHHHHHHHHHHHHHHHHHH--------HHHH----HHHHHHHH--HHHHHHHHHHHHHHHHHHHHHH-HHHHH-------- PABP-4_2 consensus MATEIGSPPRFFHMPRFQHQAPRQLFYKRPDFAQQQAMQQLTFDGKRMRKAVNRKTIDYNPSVIKYLENRIWQRDQRDMRAIQPDAGYYNDLVPPIGMLNNPMNAVTTKFVRTSTNKVKCPVFVVRWTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDSPVRAMTWSHNDMWMLTADHGGYVKYWQSNMNNVKMFQAHKEAIREARFIHNIPFSVVPIVMVKLFSKCILGAEMHGLCQFLGNFLHPINTIFFFVFTHSPFCWHLSEVVLSRYQPLQYVRDVLSAAFCTGFLFSFMINNVYTLFLFIIYCVRQEYFIPNKEFSL WDR33_2 sequence --------------------------------HHH-----------EEEE-----EEE-----------------------------EEEEE----------------EEEE-----EEE-EEEEEE-----EEEEE-----EEEEE-----EEEE-------EEEEEE-----EEEEE-----EEEE------EEE-------EEEEEEE---------EEEEEEEEEEEE-------EEEE------EEEEEEEEE----EEEE---EEEEEE--------EEEEEEEEEEEEEEEE--EEEEHHHHHHHHH---EE------- WDR33_2 psipred ------------------------------------EEEEE-----EEEE-----EEEE---------EEEE------EEEE----EEEEEE-----EEEE-----EEEEEEE-------EEEEEEE-----EEEE-----EEEEEE-----EEEEEE-----EEEEEE----EEEEE-----EEEEEE-----EEEE-----EEEEEEEE------------HHHH------------EEEEE-----EEEEEEE----EEEE-----EEEEEE----HHHHHH------EEEEEE-----EEEEE----EEEEEEE-------- WDR33_2 prof ----------------EE-------------------EEEEE----EEEE-----EEEEE-------EEEEE-----EEEEEE----EEEEE-----EEEE-----EEEEEE---------EEEEEE-----EEEE-----EEEEEE-----EEEEEE-----EEEEEE-----EEEEE----EEEEEE----EEEEEE-----EEEEEE-----------E-----------------EEEEE----EEEEEEE----EEEEEE----EEEEEE----EEEEEEEE----EEEEEE-----EEEEE----EEEEEE--------- WDR33_2 jnet --------------------------------------EEE-----EEEE-----EEE----HHHHHH-----------EE------EEEEE-----EE--------EEEEE--------EEEEEEE-----EEEEE----EEEEEE-----EEEEEE-----EEEEEE-----EEEE-----EEEEE------EEEE------EEEEEE-----EE----EEEEEE------------HHH--------EEEEEEE------E-----EEEEEE---HHHHHHHHHH----EEEEEE---EEEEEHHHHHHHH---------EEE WDR33_2 sable -------------------------------------EEEEE---EEEEEE----EEE--------EEEEEE-----EEEEE-----EEEEE-----EEEE-----EEEEEE---------EEEEEE----EEEEEE----EEEEEE----EEEEEEE----EEEEEEE----EEEEEE----EEEEE-----EEEEEE-----EEEEEE-----EEEEEEEEEE----EEE------EEEEE------EEEEEEE-----EEEE---EEEEEEE----EEEEEEEE----HHHHHHHHHHHHHHHHHHHHHHH--------EE-- WDR33_2 proteus ---------------HHH----HHHH---HHHHHHHHHHH------HHHHH---------HHHHHHHHHHHHHH-------------HHHH----HH-----------EEEEE--------EEEEEE-----EEEEE----EEEEE-------EEEE------EEEEEE-----EEEEE----EEEEE------EEEEE-----EEEEEE-----EEEEEHHHHHHHHHHHH--HH---------------EEEEEEE------HHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------- WDR33_2 sspro4 -------------------------------------EEEEE----EEEEE----EEEE--------EEEEEE----EEEEEE---EEEEEE-----EEEE------EEEEE-----EE--EEEEEE-----EEEEEE---EEEEEE-----EEEEE------EEEEEE-----EEEEEE---EEEEEE-----EEEE------EEEEEE-----EEE---EEEEEE--EEEEE----EEEEE------EEEEEE------EEEE----EEEEEE---EEEEEEEEEE----EEEEEE----EEEEEE----EEEEEE-------- WDR33_2 psspred ---------------------------------HH-----E-----E--E-----EEE-------EEEEEEEE----EEEEEE-----EEEE----------------EEEE--------EE-EEEEE---EEEEEEE---EEEEEE-----E-EEEE-------EEEEE----EEEEEE---EEEEEE-----EEEEE-----E-EEEE-----------EEEEEE------------EEEE------EEEEEEE------EEEE--EEEEEEE--------HHH------EEEE--HHHHHHHHHHHHHHHHHHH--------- WDR33_2 spineX --------------EEEE-------------------EEEE-----EEEEE-----E-----HHHHHEEEE-------EEEE-----EEEEE-----EE------EEEEEE----------EEEEEE-----EEEE-----EEEEE-------EEEE--------EEEE-----EEEE-----EEEEE------EEEE------EEEEEEE--------------------E------EEEEE------EEEEEE----E--------EEEEE-------HHHHH-------EEEEEE----EEEE-----EEEEE------E--- WDR33_2 raptorxss -------------------------------------EEEEE----EEEEEE----EEE-----HHHHH--------EEEEEE----EEEEE------E--------EEEEE---------EEEEEE-----EEEEEE---EEEEEE-----EEEEE------EEEEEE-----EEEEEE---EEEEE-----EEEEEE-----EEEEEE-----EEEE---EEEEEEE----------EEEEE-----EEEEEEEE-----EEE----EEEEEE---EEEHHHEEEEEE--EEEEE----EEEEEEEHH---EE--E-------- WDR33_2 SPARROW ---------------EEEE------EE----------EEEE-------E--------------------EEE-----EEEEEE----EEEEE------EE--H---EEEEEE-----E---EEEEEE------EE--E---EEE--E----EEE-E-------EEEEEE------E---E----E---E----E-EE-------EE-----------HH--------E------------EE-------EEEEEE-----EEEEEE----EEEEE----EEEEEEE-----EEEEEE------EEEEE---EEE-EE-----EEE- WDR33_2 *SPARROW ------------------------------------EEEEE-----EEEE-----EEEEEHHHHHHHEEEEE-----EEEEEE---EEEEEE-----EEEE-----EEEEEE--------EEEEEEE-----EEEE-----EEEEE------EEEEEEE---EEEEEEE-----EEEE-----EEEEEE-----EEEEE----EEEEEEE-----EEEE--EEEEEHHHH-HHHHHHHHHHHHH-----EEEEEE-----EEE------EEEEEEE-HHHHHHHHHH---EEEEEEE-----EEEE-----EEEEE------EEEE WDR33_2 HMMSTR ---------------------------------------------HHH-------EE---HHHHHHHHHHHHHH------EE-----EEE----------------EEEEEEE-------EEEEEEE-----EEEEE----EEEEEE-----EEEEEE-----EEEEEE-----EEEEE----EEEEEE----EEEEEE-----EEEEEE-----EEE-HHHHHHHHHHH----------------------EEEEEE-----------EE------HHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHH------------ WDR33_2 porter ----------------------HHHH----------HHHH------EEEE------E----HHHHHHHHH------EEEEEE------EE----------------EEEEEEEE-------EEEEEE-----EEEEE----EEEEEE----EEEEEEEE----EEEEEE-----EEEEE----EEEEEE-----EEEEE-----EEEEEE-----EEEEE-HHHHHHHHHHH---EHEHHHHH--------EEEEEEE-----EEEEHHHHHH----HHHHHHHHHHHHHH-HEEHHHH--HHHHEEHHHHHH---E--------- WDR33_2 spine --------------------------------HHHHHHHHHH---HHHHHHHH--------HHHHHHHHHHHHHHHHHHHHH---------------------------EEE---------EEEEEE-----EEEE-------EE-------HHHHHHH------EEEE-----EEEE------EEE-------HHHHHHHHHHHHHHHHH------EE-EEEE--------------HHHHH---------EEEEEE-------------------HHHHHHHHHH-----EEEEEE-------EEEEEEE------------EE WDR33_2 nnssp ---------EEEEE-----------------HHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHHHHHHHH----------------------EEEEEEEE---------EEEEEE-----EEEE-----EEEEEE-----HHHHHHH----EEEEEE-----EEEE-----EEEEEE-----HHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHHHHHHHHH---------EEEEEE-----HHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------------ WDR33_2 pssfinder HHHH---------------------EE----HHHHHHHHHH---HHHHHHHHH---------HHHHHHHHHHHHHHHHHHHH----------------------EEEEEEEEE-------EEEEEE------EEEE------EEEE------HHHHHH------EEEE-----EEEEE-----EEEEE------HHHHHHHHHHHHHH-------------HHHHHH-----------HHHH---------EEEEEEEE-----------EEE----HHHHHHHHHHH-----EEEEE-----EEEEEEEEE----EEE---EE-- WDR33_2 sspal ------------HHHHHHHHH-----------HHHHHHHHHEEE-HHHHHHHHH--------HHHHHHHHHHHH-------------------------------EEEEEEE-----EEEEEEEEEEE--------------EEEEEEEEEHHHHHHHHH---EEEEEEE-------------EEEEHHHHHHHHHHHHHHHHHH----------EEEE-EEEEEEEE-EEEEHHHHHHHHHHHHHH--EEEEEEEEEE-----HHHHHEEEE----HHHHHHHHHHH----EEEEEEE--EEEEEEEEEEEE------------- WDR33_2 ssp --------------------------E-------------------EEEEE----EEEEE--HHHHHHH------EEEEEEE-----EEEEEE---------HHH-HHHEEEE-------EEEEEEEEE----EEEEE---EEEEEE----HHEEEEE-------EEEEE----EEEEEE---EEEEEE-----EEEEE-----EEEEEEE----EH---EEEEEEHH--EEE-EE-----HH--------EEEEEE-----EEEH-HHHHHH-----EEEE-E-E-EE--HHHHHHEE-----HHHHEEEEEEEEEEE------- WDR33_2 sspred ----------------------------------------------EE--------EEE--------EEEEE------E--------EEEEE-----EEE-------EEEEE---------EEEEEE-----EEEE-----EEEEE-----------------EEEEEE-----EEEE-----EEEEE----------------EEEEEE----------EEEEE------EE--------EEEE-----EEEEE------EEE-----EEEEEE---------EEE------EEEE-----EEEEEE---EEEEEEE----EEE- WDR33_2 netsurfp ---------------------------------------EE-----EEEE-----EEE----HHHHH-----------EEEEE-----EEEE---------------EEEEE---------EEEEEE-----EEEEE----EEEEEE-----EEEEEE-----EEEEEE-----EEEEE----EEEEE------EEEEEE----EEEEEE-----------EEEEEE----E-------EEEEE-----EEEEEEE------EE----EEEEEEE--------EEE------EEEEE---HHHHHHHHHHHHHHHHH--------- WDR33_2 soprano -------------------------------------EEEE-----EEEE-----EEE----HHHHHHHEEE------EEEE-----EEEEE--------------EEEEEE---------EEEEEE-----EEEEE----EEEEEE-----EEEEEE-----EEEEEE-----EEEEE----EEEEE------EEEEE-----EEEEEE-----------EEEEEH------------EEEE------EEEEEEEE-----EE-----EEEEEE----HHHHHHHH-----EEEEEE----EEEEEHHHHE-E------------ WDR33_2 consensus MQEIIASVDHIKFDLEIAVEQQLGAQPLPFPGMDKSGAAVCEFFLKAACGKGGMCPFRHISGEKTVVCKHWLRGLCKKGDQCEFLHEYDMTKMPECYFYSKFGECSNKECPFLHIDPESKIKDCPWYDRGFCKHGPLCRHRHTRRVICVNYLVGFCPEGPSCKFMHPRFELPMGTTEQPPLPQQTQPPAKQRTPQVIGVMQSQNSSAGNRGPRPLEQVTCYKCGEKGHYANRCTKGHLAFLSGQ CPSF4_2 sequence --------------HHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEEEE---------------------- CPSF4_2 psipred ---EE-------EEHHHHHHHHH---------------HHHHHH---------------------EEEHHHHHHH-------EEE---------EEEEEE-----------EEE----------HHH-------------HHHHHHHHHHHHH----------------------------------------------------------------EEEEE---------------------- CPSF4_2 prof --------------HHHHHHHHH----------------------------------EE-----EEEEE-------------------------EEEEE----E-------EEEE---------HHHHH-------------------HHHHH----------------------------------------------------------------EEEEE---------------------- CPSF4_2 jnet --------------HHHHHHHH------------------HHHHH---------------------EHHHHH--------------------------E-------------------------------------------------HHH------------------------------------------------------------------EEEE----------------------- CPSF4_2 sable --------------HHHHHHHHH------------------------------------------EEE-HHH-----------------------HHHHHHH---------EEE--------------------------------------------------------------------------------------------------------EEEE---------------------- CPSF4_2 proteus --HHH---------HHHHHHHH--------------HHHHHHHHH--------------E---EEEEEEE--E-EEE---EEEEE----HH----HHHHHH-----------------------HHHH---------H----------H-H--------------------------------------HH--------------------------EEEEE--------------EHEE---- CPSF4_2 sspro4 --------------HHHHHHHHH---------------------------------------------HHHHH-----------------------EE--------------------------HHHHH--------------------HHHH------------------------------------------------------------------------------------------- CPSF4_2 psspred HHHHHHH-------HHHHHHHHH---------------HHHHHHHHH---------------HHHHHHHHHHH---------------------------------------------------------------------------HHHHH------------------------------------------------------------------EE----------------------- CPSF4_2 spineX -----------EE-E-----------------------EEEEEE------------------------EEE---------------------------------------------------------------------------E----------------------------------------------------------------------EEEE----------------------- CPSF4_2 raptorxss -HHHH---H-----HHHHHHHHH---------------------------------E-----------HHHH----------------------------------------E-------------HH----------------------HH------------------------------------------------------------------EEE----------------------- CPSF4_2 SPARROW -----------EE--HHHHHHH---------------------H----------------------HHHHHHH----------H-------------HH---------------------------------------------------H-------------------------------------------------------------------EE------------------------ CPSF4_2 *SPARROW HHHHHHHHHHEEEEHHHHHHHHH--------E------EEHHHH-----------HHHH-----EEEHHHHHHHH-------EEE----H-H---EEEEE-----------HHH----H--------------------HHHHHHHH-H-H----------------------------------------------------------------HHH--H--------E-------------- CPSF4_2 HMMSTR ---EEE--------HHHHHHHHH---------------HHHHHHH---------------------E-HHHH------HHH---E---------E-HHHHHH----E-----E-----------------------------------------------------------------------------------------------------------------------------EE---- CPSF4_2 porter --EEEHHHHH----HHHHHHHHH---------------EEEEEHHHH-----------------HHH-HHHHH---------------------HHHHHHH------------------------------------------------HHH----------------------------------------------E-------------------EE---------------HHHH----- CPSF4_2 spine HHHHHHH--------HHHHH-------------------HHHHHHH-------------------EEE---------------EE-----------EEE-------------EE-------------------------------EEEE----------------------------------------------EEEE------------------EEEE----------------EEEE--- CPSF4_2 nnssp --HHHHHHHHHHHHHHHHHHHHH-------------HHHHHHHHHHHH---------------EEEEEEEEEEEEEE---EEEEEE---------------------------------------------------------EEEEEEE--------------------------------------------EEEEEEE------------------------------------------- CPSF4_2 pssfinder HHHHHHH---EEEEEEEEHHHHH--------------EEHHHHHHHH---------EEEE----EEE-EEE------------EEE----------EEEE-----------EEEE-----------------------------EEEEEEEE------------------------------------------EEEEEEE----------------EEEEE--------------EEEEEE-- CPSF4_2 sspal HHHHHHHHHHHHHHHHHHHHHHH---------HHHHHHHHHHHHHH------------------EEEEEEEEE------HHHHHHHHH-------EEEEEEE---------------------------------------EEEEEEEE-EEEEEEE-------------------------------------EEEEEEE----------------EEEE----------------------- CPSF4_2 ssp --------------HHHHH---------------------EEEHHH-----------------------H-HH-------------------------------------------------------------------------------------------------------------------------------------------------EEEE---------------------- CPSF4_2 sspred ----------------HHHHHH------------------------------------------HHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------- CPSF4_2 netsurfp --------------HHHHHHHHH-------------------EH----------------------E--HHH-------------------------EHH--------------------------H-----------------------HH------------------------------------------------------------------EEE----------------------- CPSF4_2 soprano --------------HHHHHHHHH-----------------HHHH----------------------E-HHHH-------------------------E----------------------------------------------------H-------------------------------------------------------------------EEE----------------------- CPSF4_2 consensus MTSIIKLTTLSGVQEESALCYLLQVDEFRFLLDCGWDEHFSMDIIDSLRKHVHQIDAVLLSHPDPLHLGALPYAVGKLGLNCAIYATIPVYKMGQMFMYDLYQSRHNTEDFTLFTLDDVDAAFDKIQQLKFSQIVNLKGKGHGLSITPLPAGHMIGGTIWKIVKDGEEEIVYAVDFNHKREIHLNGCSLEMLSRPSLLITDSFNATYVQPRRKQRDEQLLTNVLETLRGDGNVLIAVDTAGRVLELAQLLDQIWRTKDAGLGVYSLALLNNVSYNVVEFSKSQVEWMSDKLMRCFEDKRNNPFQFRHLSLCHGLSDLARVPSPKVVLASQPDLECGFSRDLFIQWCQDPKNSIILTYRTTPGTLARFLIDNPSEKITEIELRKRVKLEGKELEEYLEKEKLKKEAAKKLEQSKEADIDSSDESDIEEDIDQPSAHKTKHDLMMKGEGSRKGSFFKQAKKSYPMFPAPEERIKWDEYGEIIKPEDFLVPELQATEEEKSKLESGLTNGDEPMDQDLSDVPTKCISTTESIEIKARVTYIDYEGRSDGDSIKKIINQMKPRQLIIVHGPPEASQDLAECCRAFGGKDIKVYMPKLHETVDATSETHIYQVRLKDSLVSSLQFCKAKDAELAWIDGVLDMRVSKVDTGVILEEGELKDDGEDSEMQVEAPSDSSVIAQQKAMKSLFGDDEKETGEESEIIPTLEPLPPHEVPGHQSVFMNEPRLSDFKQVLLREGIQAEFVGGVLVCNNQVAVRRTETGRIGLEGCLCQDFYRIRDLLYEQYAIV CPSF2_1 sequence ---EEEEEEEE--------EEEEEE--EEEEEE------------HH---------EEEE----------HHHHH-------EEEE-HHHHHHHHHHHHHHHHHH----------HHHHHHHHH--EEE----EEE-------EEEEEE-------EEEEEEEE--EEEEEEE-----------------------EEEE-----------HHHHHHHHHHHHHHHH----EEEEE---HHHHHHHHHHHHHHHHH---------EEEE-HHHHHHHHHHHHHHHHHHHHHHHHHHH-----------EE---HHHHH------EEEE--------HHHHHHHHH------EEEEE-------HHHHHH---------EEEEEEEEEE---HHHHHHHHHHHHHHHHHH----------------HH-----------EEEEE----------HHHH-----------------------------------HHHHHHHH--------------------EEEEEEEEEEEEEEEEEEE------HHHHHHHHHH----EEEEE---HHHHHHHHHHHHH-----EEEEE-----EEE---EEEEEEEEE-HHHHH----EE----EEEEEEEEEE---------------------------------HHHHHHHHHH----------------------------------EEE----HHHHHHHHHH----EEEE--EEEE--EEEEEE-----EEEE----HHHHHHHHHHHH----- CPSF2_1 psipred ---EEEEEE---------EEEEEEE---EEEEE----------HHHHH--------EEEEE---------HHHHHHH----EEEEE---HHHHHHHHHHHHHHHH----------HHHHHHHHHHH--EEEEEEEEE------EEEEEE----HHHHHHHEEEE----EEEEEEE---------------------EEEEE-----------HHHHHHHHHHHHHHHHH---EEEEE----HHHHHHHHHHHHHHHH-------EEEEE--HHHHHHHHHHHHHHHHHHHHHHHHHH------EEEE-EEEE-HHHHH-----EEEEE---------HHHHHHHH------EEEEEEE----HHHHHHH---------EEE-EEEEE---HHHHHHHHHHHHHHHHHHHH------------HHHHHH----------EEEEEE-----HHHHHHHHHHH-----------------EEE------EEE----HHHHHHHH-------------------EEEEEEEEEEEEEEEEEEE------HHHHHHHHHH----EEEEEE--HHHHHHHHHHHHHH-----EEE-----EEEE----EEEEEEEEHHHHHHHHHEE-----EEEEEEEEEEEE---------------------------------------------------------------------------EEE----HHHHHHHHHH---EEEEE--EEEE--EEEEEE----EEEEEE---HHHHHHHHHHHHHH--- CPSF2_1 prof ----EEEEEEE--------EEEEE----EEEEE----------------------EEEEE-----HHHHHHHHHHH------EE---HHHHHHHHHHHHHHHHH-----------HHHHHHHHHHH--------EEE------EEEEE-----EE--EEEEEEE----EEEEEE----------------------EEEEE-----------HHHHHHHHHHHHHHHH----EEEEE----HHHHHHHHHHHHHH----------EEEE---HHHHHHHHHHHHHHHHHHHHHHHHH-----------EE---HHHH------EEEEE-------HHHHHHHHHH------EEEEE----------------------EE---------HHHHHHHHHHHHHHHHHHHHHH---------------------------EEEEEE----------------------------------EE----------------------------------------EEEEEEEEEE---EEEEE-------HHHHHHHHHH----EEEEE---HHHHHHHHHHHHHH-------E------EEEEE----EEEEEHHHHHHHHHHHHHH---EEEEEEEEE-------------------------------------------------------------EEEE-------------EEE---HHHHHHHHHHH---EEEE--EEEEE--EEEEEE----EEEEE-----HHHHHHHHHH------ CPSF2_1 jnet ---EEEEEE----------EEEEEE---EEEEE-----------HHH--------EEEEE----HHHHHHHHHHHHH-----EEEE--HHHHHHHHHHHHHHHHHH---------HHHHHHHHHH--EEE---EEEE-----EEEEEE---------EEEEEEE---EEEEEEE---------------------EEEEE------------HHHHHHHHHHHHHHHH----EEEEE---HHHHHHHHHHHHHHHH-------EEEEEE-HHHHHHHHHHHHHHHH--HHHHHHHHH-----------EE---HHHHHH----EEEEE--------HHHHHHHHH------EEEEE-------HHHHHHH-------EEEEEEEEEE---HHHHHHHHHHHHHHHHHHHH--HH---------HHHHH------------EEE----------HHHHH---------------------E-----------------HHHHHHH-------HHHHH-----EEEE--EEEEEEEEEEEEE-----HHHHHHHHHH-----EEEE---HHHHHHHHHHHHHH-----EEEE-----EEEEE---EEEEEEE-HHHHHHH--------EEEEEEEEEE-----------------------------------------------------------------------------EE-----HHHHHHHHHH----EEE---EEEE--EEEEEE----EEEEE----HHHHHHHHHHHHHHHHH CPSF2_1 sable --EEEEEEEE--------EEEEEEE--EEEEE-EEE-------------------EEEEEE---HHHH--HHHHHHH----EEEEE-HHHHHHHHHHHHHHHHHHH---------HHHHHHHH--EEEE----EEEE-----EEEEEEEEE-----EEEEEEEE---EEEEEE-EE--------EEEE------EEEEEEEE--------HHHHHHHHHHHHHHHHHH--EEEEEEEE---HHHHHHHHHHHHHHH------EEEEEEE--HHHHHHHHHHHHH----HHHHHHHHH---------EE-E---HHHHH----EEEEEEE-------HHHHHHHHH-----EEEEEEE---E--HHHHHH----EEEEEEEEEEEEEEEHHHHHHHHHHHHHHHHHHHH----EEEEEHHHHHHHHHHHHHHHHH----EEEEE------HHHHHHHHHH-------------------EE---------------HHHHHHHHH----------------EEEEEEEEEEEEEEEEEEEE-----HHHHHHHHHH---EEEEEE---HHHHHHHHHHHHHHH---EEEEE-----EEEEEEEEEEEEEEE-HHHHHH---------EEEEEEEEEEE---------------------------------------------------------------------------EEEE----HHHHHHHHHH---EEEEE--EEEE--EEEEEE----EEEEEE---HHHHHHHHHHHHH---- CPSF2_1 proteus ---EEEEEE----------EEEEEE---EEEE-------------------HHH--EEEE------HH-HHHHHHHHH-----EE----HHHHHHHHHHHHHHHHH---------HHHHHHHH--EEEEE--EEEEE-------EEEE----HHHHHHHHHHHH----EEEEE--------HH-------------EEEEE----------HHHHHHHHHHHHHHHHH----EEEEHHH--HHHHHHHHHHHHHHH---------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------EEEE------HHHHH-----EEEEE--------HHHHHHHHH------EEEEE------HHHHHHH------EEEEEE--EEEE---HHHHHH------HHHHHHHHH--------------HH------------EEEE-----------HHH----------H--EEH-----EE---H-----H---H--------------------H-----EEEEEEEEEEEEEEEEEEEE------HHHHHHHHH----EEEEEE--HHHHHHHHHHHHHH-----EEE------EEEE-----HHHEEHHHHHHHHHEE------EEEEE--EE--EEEE----EEE--------------E------HHHHHHHHHHHH--------------------------------EEE---HHHHHHHHHHH---EEEEE-EEEEE--EEEEEE----EEEE-----HHHHHHHHHHHHHH--- CPSF2_1 sspro4 ---EEEEEEE---------EEEEEE--EEEEEE-----------HHHH--------EEEE----HHHHHHHHHHHHHH----EEE--HHHHHHHHHHHHHHHHHHH---------HHHHHHHHHH-EEE---EEEEE------EEEEEE--------EEEEEEE----EEEEEE----------------------EEEE-----------HHHHHHHHHHHHHHHHHH--EEEEEE---HHHHHHHHHHHHHHHH--------EEEEE-HHHHHHHHHHHHHHHHH-HHHHHHHHHH----------EEE--HHHHHH----EEEEE--------HHHHHHHHHH-----EEEEE-------HHHHHH-----EE--EEEEEEEEEEEHHHHHHHHHHHHHHHHHHH-----EEEEE----HHHHHHHHHHHH-----EEEE--------HHHHHH---------------------E--HHHHHHHHHHHHHHHHHHHHHHHH-------HHH-----EEEEEEEEEEEEEEEEEEE------HHHHHHHHHHH---EEEEE---HHHHHHHHHHHHHHH----EEEE-----EEEEEEEEEEEEEE--HHHHHH---EEE---EEEEEEEEEE-----------------------------------------------------------------------------EEE----HHHHHHHHHHH---EEEE--EEEE--EEEEEEE----EEEEE----HHHHHHHHHHHHH--- CPSF2_1 psspred ----EEEEE----------EEEEEE--EEEEEE--------HHHHHHH--------EEEE----HHHHHHHHHHHHHH----EEEE-HHHHHHHHHHHHHHHHHHH---------HHHHHHHHHH-EEE----EEEE------EEEEEE-------EEEEEEEE--EEEEEEE-----------------------EEEE-----------HHHHHHHHHHHHHHHHHH--EEEEEE---HHHHHHHHHHHHHHHH--------EEEE--HHHHHHHHHHHHHHHHHHHHHHHHHHHH---------EEE---HHHHHH----EEEEE-------HHHHHHHHHH------EEEEE-------HHHHHHH-------EEEEEEEEEE--HHHHHHHHHHHHHHHHHHHHHHHHH-------------------------EEEE------H--HHHHHH-------------------EE----HHHHHH---HHHHHHHHHH-----------------EEEEEEEEEEEEEEEEEEEE------HHHHHHHHHH----EEEEE---HHHHHHHHHHHHHH----EEEEE----EEEEEEEEEEEEEEEE-HHHHH---EEE---EEEEEEEEEE-EE----------------------HHHHH------HHHHHHHHHH-------------------------------EEEE----HHHHHHHHHHH---EEE---EEEE--EEEEEE----EEEEE----HHHHHHHHHHHHHHHH- CPSF2_1 spineX ----EEEEE-----EE---EEEEEE--EEEEE---------HHHHHH---------EEEE-----------HHHHH-----EEEE--HHHHHHHHHHHHHH--------------HHHHHHHHHHEEEE----EEEE-------EEEE---------EEEEEEE---EEEEEE-----------------------EEEE-----------HHHHHHHHHHHHHHHHH---EEEEE---HHHHHHHHHHHHHHHH----------EEEE---HHHHHHHHHHHHHHH-HHHHHHHHH----------------HHHHH------EEEE----------HHHHHHH------EEEE--------HHHHHH----------EEEEEEEEEE--------HHHHHHHHHH------EEEEE-------HH-----------EEEEEE--EEEEEEEEEEE------------------EEEEE-----EEE--------------------------------EEEEEEEEEEE--EEEEE----------HEEEEEEEE--EEEEE---HHHHHHHHHHHHHH-----EEE------EEE-----EEEEEEE--EEEEEEEEE----EEEEEE-------E----EEEEEE------------EEE--------------------------------EE--------------EEE------HHHHHHHHH----EEEE--EEEE--EEEEEE-----EEEE----HHHHHHHHHHH---EE- CPSF2_1 raptorxss ---EEEEEE----------EEEEEE--EEEEEEE-------HHH-HHH--------EEEE----HHHHHHHHHHHHH-----EEE--HHHHHHHHHHHHHHHHHHH---------HHHHHHHHHH-EEE----EEEE-------EEEEEE----EEEEEEEEEE--EEEEEEE-----------------------EEEEE----------HHHHHHHHHHHHHHHHH---EEEEEE--HHHHHHHHHHHHHHHHH---------EEEE-HHHHHHHHHHHHHHHHH-HHHHHHHHH------H----EE---HHHHHH----EEEEEE-------EHHHHHHHH------EEEEE-------HHHHHHH-----E--EEEEEEEEEEEHHHHHHHHHHHHHHHHHHHH---H-H------HHHHHHH---H-------EE-E-E--------------E-----EE--------------HHHHH------HHHHHHHHH--HH-----HHH------EEEEEEEEEEEEEEEEEEEE------HHHHHHHHHH----EEEEE---HHHHHHHHHHHHH------EEEE-----EEEEEEEEEEEEEEE-HHHHHHHHHHE----EEEEEEEEEE--------------------------------------HHH--------------HHHHH-----------------EEE----HHHHHHHHHH----EEEE--EEEE--EEEEEE-----EEEE----HHHHHHHHHHHHHH--- CPSF2_1 SPARROW -----EEEE----------EEEEEE--EEEEEE---------HH-------HHH--EEE-----HHH---HHHHHHH------EE---HHHHHHHHHHHHHHHHHHH--------HHHHHHHHHHEEEE----EEEE-------EEEEE------EEEEEEEEE----EEEEE-----------------------EEEE-----------HHHHHHHHHHHHHHHHH---EEEEE-----HHHHHHHHHHHHHH----------EEEE--HHHHHHHHHHH-HHH--HHHHHHHHH----------EEE---HHHHH-----EEEEE--------HHHHHHHHH------EEEEE-------HHHHHH----------EEEEEEEEEEE--HHH--HHHHHHHHHH-------EE------HHHHHHHHHHHH----EEEEE----HHHH--HHHHHHH------------------EE------HHHHHHHHH--HHHH-HH----------------HHHHHHHHHHHH--HHH--HH----HHHHHHHHHHH----EEEEE--HHHHHHHHHHHHH-------EEE-----EEEE----EEEEEEEHHHHHHHHHH-----EEEEEEE-EEE---------------------HHHHH---------------------------------------------------EE-----HHHHHHHHHH----EEE---EEEE--EEEEEE----EEEEE----HHHHHHHHHHHHHH--- CPSF2_1 *SPARROW ----EEEEE----------EEEEEE---EEEEE--------HHHHHHH---HH---EEEEE---H-H-----HHHHHH---EEEEEEE-HHHHHHHHH-HEEEEE----------HHHHHHHHHHHHHHEH--EEEEE------EEEEE----EE---EEEEEE----EEEEEE---HHHHHH-------------EEEEE----------HHHHHHHHHHHHHHHHHH---EE---HH---HHHHHHHHHHHHHHH--------EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----EEEEHHEHHH-HHHHH-----EEEEEE---------HHHHHHHHH----EEEEEE----HHHHHHHHH-----EEEEEE--EEEEE---HHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHH----EEEEEE--HHHHHHHHHHHHHHHHH--------EE-----EE------EEEHHH-HHHHHHHHHHHHHH----HHHHH----EEEEEEEEEEEE-EEEEE-------HHHHHHHHHH-----EEEEEEHHHHHHHHHHHHHHH-----EEE---HH-EE---H-H-EEEEEEHHHHHHHHHHH-----EEEEEHHEEEEE-----------HH--HHHHHHHHHHH-----HHHHHHHHHHHHH---------HHHHH----------------EEEEE---HHHHHHHHHHH--EEEEEEEEEEEE-EEEEEE-----EEEEEE----HHHHHHHHHHHHHEE CPSF2_1 HMMSTR -----EEEE----------EEEEEE--EEEEE------------HHH----HHH--EEE-----HHHH--HHHHHHH------EEEEHHHHHHHHHHHHHHHHH-----------HHHHHHHHH-EEEE-----EEE------EEEEEEE-------EEEEEEE---EEEEE------------------------EEEEE----------HHHHHHHHHHHHHHHHH---EEEEE-----HHHHHHHHHHHHHH----------EEEE-HHHHHHHHHHHH-HHH--HHHHHHHH------------EEE--HHHHHH----EEEEE-------HHHHHHHHHH------EEEE---------HHHHH----EEEEEEEEEEEEE----EE----EEE--------HHHH---------------------------EEEEE---------EE------------------------EE-----EE---------------------------------EEEE--EEEEEEEEEEEEEEE-----HHHHHHHHH----EEEEEE---HHHHHHHHHHHHH-----EEEE----EEEEE----EEEEEEE-HHHHHHHEEEE----EEEEEEEEEEEEEEEEE--EEEE------------EEE-------E------------------------E----------------EEE--HHHHHHHHHHHH---EEEEE--EEEE--EEEEEE----EEEEE----HHHHHHHHHHHHHH--- CPSF2_1 porter ---EEEEEEEE--------EEEEEE--EEEEEE--------HHHHHHHH------EEEEE----HHHHHHHHHHHHH-----EEEE-HHHHHHHHHHHHHHHHHH----------HHHHHHHHHHEEEE----EEEEE-----EEEEEEE-------EEEEEEE---EEEEEEE---------------------EEEEEE----------HHHHHHHHHHHHHHHHH----EEEEE--HHHHHHHHHHHHHHHHHH-------EEEEE-HHHHHHHHHHHHHHHHH-HHHHHHHHH----------------HHHHH-----EEEEE-------HHHHHHHHHH------EEEEE--------HHHHH-----EEEEEEEEEEEEE-HHHHHHHHHHHHHHHHHHHHHHHHHH----------HHHH-----------EEEEE-----HH-HHHHHH---------HHHHHHHHH-----HHHH--HHH-HHHHHHHH---------------------EEEEE--EEEEEEEEEEEEE-----HHHHHHHHHH----EEEEE----HHHHHHHHHHHHH----EEEEE-----EEEEE-EEEEEEEE--HHHHHHHHH------EEEEEE-EEEEEEEEE----E--HHHH------HHH-------HHHH--HHHHHHH-------------------------------EE-----HHHHHHHHHH----EEEE--EEEE--EEEEEE----EEEEEE---HHHHHHHHHHHHHH--- CPSF2_1 spine HHHHHHHH------HHHHHHHHHHH----EEE---------HHHHHHHHHHHHHH--EEE-----------------------EEE---------HHHHHHH--------EEEEE---HHHHHHHHHHH---EEEE--------EE------------HHHHHH----EEEEEEE------EEE------------EEE-------EE----HHHHHHHHHHHHHHHH----EEEEE----HHHHHHHHHHHHHHH------EEEHHHHH-----EEE--HHHHHHHHHHHHHHHH----------------------------EEEE----------HHHHHHHH-----EEEEEE--------EEEE------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------HHHHHHHH-----------------------HHHHHH--------------------------EEEEHHHHHHHHHHHHH---------------------------EEE--EEEEEE--------HHHHHHHHH---EEEEE-----HHHHHHHHHHH-----EEEEHHHHHHHHHH----EEEEEE----HHHHHHHHH----HHHHHH-------------EEEE-------------EEE------HHHHHHHHHHHH------------------------------EE-----HHHHHHHHHHH--------EEEEE---EEE-------EE--------HHHHHHHHHHHHHEE CPSF2_1 nnssp --EEEEEE------HHHHHHHHHHHHHHHHHHH--------HHHHHHHHHHHHHHHHHH----------------------EEEEEE--HHHHHHHHHHHHHH------------HHHHHHHHHHHHHHHHHHHH----------------------EEEEEEE-----EEEEE--------------HHH----EEEEE-----------HHHHHHHHHHHHHHHH-----EEEEE--HHHHHHHHHHHHHHHHHHH----HHHHHHH-----------HHHHHHHHHHHHHHH------HHHHHHHHHH------------EEEEEE---------HHHHHHHHH-----EEEEEEE-HHHHHHHHHH-------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHH-HHHHHHHHHHHH-------HHHHHHHHHH------HHHHHHHHHH-----------------HHHHHHHHH-------------------------EEEEEEEEEEE----------HHHHHHHH----EEEEE--------HHHHHHHH-----EEE--------------EEEEEEE-HHHHHHHHHHHHHHHHHHHHHHHH---------EEEEE-----------EEEEE----HHHHHHHHHHHHHH-----------------------------EEEEE-HHHHHHHHHHHHH--EEEE---EEEE--EEEEEE------------HHHHHHHHHHHHHHHH-- CPSF2_1 pssfinder HHHHHHH---------HHHHHHHHHH---HHH---------HHHHHHHHHHHHHH--EEE----------HHH------HHHHHH--------HHHHHH-----------EEEE----HHHHHHHHHH----EEEEEE-----EEE-------EE--EEEEEEE-----EEEEEE-----EEEE----EEE--------------EEE------HHHHHHHHHHHHHH----EEEEE----HHHHHHHHHHHHHH-------EEEE------EEEEEE--HHHHHHHHHHHHHH---------EE---EE--------------EEEE-----------HHHEE-------EEEEEEE-----HHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHH---------HHHH---------HHHHHH--------------HHHHHHHH-------------HHHHHHHH-----------HHH-------EEE---EEEEEEEEEE-------HHHHHHHHHH----EEEEEE----HHHHHHHHHHH-----EEEE-HHHHHHHH----EEEEEEEE-------HHH-----HHHHHHHHEEEEEEEE----EEEEE-----------EEEE------HHHHHHHHHHH-------------------------------EEE------HHHHHHHHH-----EEEEEEE------EEE----EEEEEE-----HHHHHHHHHHHH-EE CPSF2_1 sspal -EEEEEEE-----HHHHHEEEEEEEHHHHHHHHH---HHHHHHHHHHHHHHHH----EEEE-------------EEEEEEE--EEEEEEEE---HHHHHHHHH---------HHHHHHHHHHHHHHHHH--------------EEEE---------HHHHHHHHH----EEEEE----------------------EEEE----HHHHHHHHHHHHHHHHHHHHHHHHH---EEEEEHHHHHHHHHHHHHH-----------EEEHHHHH-EEEEEEE--HHHHHHHHHHHHHHHH---------------------------EEEE-----------HHHHHHHHHH---EEEEEEE----HHHHHHHHH----HHHHHHHHEEEEHHHHHHHHHH-HHHHHHHHHHHHH----------HHHHHHHHHH--HHHHHHHHHHH-------HHHHHHHHH-------------------------HHHHHHHHHHHH-----------HHHHHHHHH-----------EEEEEEEEEE--------HHHHHHHHHHH-EEEEEEE------HHHHHHHHHH----EEEEE------------EEEEEEEEE-EEEE--HHHHHHHHHHHHH--HHHHHHHHHEEEEEE-------------------------HHHHHHHHHH---------HHHHHHHHH----------------HHHHHHHHHHHHH------EEEEEEEE--EEEE------------HHHHHHHHHHHHHHHH---- CPSF2_1 ssp ----EEEEEEE-------EEEEEEE---EEEEE-----------HHHH------EEEEEE-----HHHHHHHHHHHH-----EEEE-HHHHHHHHHHHHHHHHHH-------------HHHHHH--EEE---EEEEE------EEEEEEE-------EEEEEEEE--EEEEEEE----------------------EEEEE-------------HHHHHHHHHHHHHHH---EEEEEEHHHHHHHHHHHHHHHHHHH------EEEEEE-HHHHHHHHHHHHHHHHH-HHHHHHHHHH----------EEE--HHHHHH----EEEEEE-----HHHHHHHHHHHH-----EEEEEE------HHHHHHH----EEEE----EEEEE-HHHHHHHH-HH-H-HHHHHHHHHHH-------HHHHHHHHHH--HH-----EEEEE------------------------HH-----------HHH-H-------------------------HHHH----EEEEEE-EEEEEEEEEEEEEEE----HHHHHHHHHHH---EEEEE------HHHHHHHHHHHH----EEEE-----EEEEEE-EEEEEEEE-HHHHHHHHHHH-----EEEEEEEH---EEEE------------------HH---------------------------------------------------EE-----HHHHHHHHH-----EEEE--EEEE---EEEEEE---EEEEEE----HHHHHHHHHHHHH--- CPSF2_1 sspred ---EEEEEEE--------EEEEEEE---EEEEE-----------------------EEEE-------HHHHHHHHHH-----EEEE-HHHHHHHHHHHHHHHHHHHH--------HHHHHHHHHHHEE-----EEEE------EEEEE---------EEEEEEE----EEEEE-----------------------EEEEE-----------HHHHHHHHHHHHHHHH----EEEE---HHHHHHHHHHHHHHHHH---------EEEE-HHHHHHHHHHHHHHHHH-HHHHHHHHHH---------------HHHHH------EEEE--------HHHHHHHHH-------EEEE-------HHHHHH----EEEE--EEEEEEEEEE--------HHHHHHHHHH------EEEEE----HHHHHHHHHHHH----EEEE-----------------------------------EEE-----------HHHHHHHHHHHHHH---------------EEEEEEEEEEEE--EEEEEE-----HHHHHHHHHH----EEEEE---HHHHHHHHHHHHHH-----EEE------EEEEE----EEEEEE-HHHHHHEEEEE----EEEEEEEEE-----------------------------------HHHHHHHH--------HHH-H----------------------EEE----HHHHHHHHHH----EEE---EEEE--EEEEEE----EEEEE----HHHHHHHHHHHHH---- CPSF2_1 netsurfp ---EEEEEEE---------EEEEEE--EEEEEE---------HHH----------EEEEEE---HHHHHHHHHHHHHH----EEEE--HHHHHHHHHHHHHHHHHHH--------HHHHHHHHH---------EEEE------EEEEE---------EEEEEEE---EEEEEEE---------------------EEEEEE-------------HHHHHHHHHHHHHH---EEEEEE-HHHHHHHHHHHHHHHHHH--------EEEEE--HHHHHHHHHHH-HHH--HHHHHHHHHH----------EE---HHHHHH----EEEEE--------HHHHHHHHH------EEEEE-------HHHHHHH--------EEEEEEEEE----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------------EEE-------------H---------------E----EEE----H-----------HHH-----------HHH--------EEEEEEEEEEEEEEEEEE------HHHHHHHHHHH----EEEE---HHHHHHHHHHHHHHH----EEEE-----EEEEEEEEEEEEEE--HHHHHHHHHH------EEEEEEEEE-------------HHH---------HHH-----------------------------------------H-------EE-----HHHHHHHHHH----EEEEEEEEEE--EEEEEE----EEEEE----HHHHHHHHHHHHHHH-- CPSF2_1 soprano ---EEEEEE----------EEEEEE--EEEEEE---------HHHHHH--------EEEE-----HHH--HHHHHHH-----EEEE-HHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHEEE----EEEE------EEEEEE--------EEEEEEE----EEEEEE----------------------EEEEE----------HHHHHHHHHHHHHHHHH----EEEEE---HHHHHHHHHHHHHHHH--------EEEEE-HHHHHHHHHHHHHHHHH-HHHHHHHHH-----------EE---HHHHH-----EEEEE--------HHHHHHHHH------EEEEE-------HHHHHH---------EEEEEEEEE--HHHHHHHHHHHHHHHHHHHHHH-----------HHHHHH-----------EEEE---------HHHHHH--------------------EE-------------HHHHHHHH-------------------EEEEEEEEEEEEEEEEEEE------HHHHHHHHHH----EEEEE---HHHHHHHHHHHHHH-----EEEE-----EEEE---EEEEEEEE-HHHHHHHHHH-----EEEEEEEEEE---------------------------------------HH------------------------------------EEE----HHHHHHHHHH----EEEE--EEEE--EEEEEE----EEEEE----HHHHHHHHHHHHHH--- CPSF2_1 consensus MSEGVDLIDIYADEEFNQDPEFNNTDQIDLYDDVLTATSQPSDDRSSSTEPPPPVRQEPSPKPNNKTPAILYTYSGLRNRRAAVYVGSFSWWTTDQQLIQVIRSIGVYDVVELKFAENRANGQSKGYAEVVVASENSVHKLLELLPGKVLNGEKVDVRPATRQNLSQFEAQARKRIPPRAHSRDSSDSADGRATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPPPPIPPPPPLSSSFGVPPPPPGIHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFPPPNATVGPPPDTYMKASAPYNHHGSRDSGPPPSTVSEAEFEDIMKRNRAISSSAISKAVSGASAGDYSDAIETLLTAIAVIKQSRVANDERCRVLISSLKDCLHGIEAKSYSVGASGSSSRKRHRSRERSPSRSRESSRRHRDLLHNEDRHDDYFQERNREHERHRDRERDRHH CPSF7_2 sequence ----------------------------------------------------------------------------------EEEE--------HHHHHHHHHH------EEEEEEE---------EEEEEE--HHHHHHHHHH-----------EE-------HHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHH---HHHHHHHHHHH--------HHHHHHHHHHHHHHHH-------HHHHHHH-------------------------------------------------------HHHHHHHHHHHHHHHHHHH--- CPSF7_2 psipred ---------------------------------------------------------------------------------EEEEEE-------HHHHHHHHHH--------EEEEE---------EEEEEE--HHHHHHHHHHH---------EEEEEEE-------HHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHH------HHHHHHHHHHH-----HHHHHHHHHHHHHHH-------HHHHHHHHHHHHHH-----------------------------------------------------HHH-------HHH----- CPSF7_2 prof ---------------------------------------------------------------------------------EEEEE-------HHHHHHHHHHHH-----EEEEEEE---------EEEEEE--HHHHHHHHHH------------------HHHHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHH----------HHHHHHHHHHHH---------EEEEEE-----EEEEEE------------------------------------------------------------------ CPSF7_2 jnet ----------------------------------------------------------------------------------EEEEE-------HHHHHHHHHH-------EEEEEE---------EEEEEE--HHHHHHHHHH----------EEE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHH-----------------------HHHHHHHHHHHHH----------------HHHHH-------------------------------------------------------HHHHHH----------- CPSF7_2 sable ---------------------------------------------------------------------------------EEEEEE-------HHHHHHHHHHH-----EEEEEEEE-------EEEEEEE--HHHHHHHHHHH--------EEEEEE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHH-----------------HHHHHH-----------------------------HHHHHHHHHHHHH----------HHHHHHH---------- CPSF7_2 proteus ------HHHH--HHHHH------------HHH-------------HH----------------------EEEEE------EEEEEE---EE---HHHHHHHHHH----HHEEEEEE----------EEEEEE--HHHHHHHHHH-----------EE--------HHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHHH-H---HHHHHHHHHHHHHH----H-------------------------------HHHHHHH-------HHHHHH---HHHH-HHHHH--- CPSF7_2 sspro4 ----------------------------------------------------------------------------------EEEE--------HHHHHHHHHHH----EEEEEEEE--------EEEEEEE--HHHHHHHHHHH---------EEE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHH---------------------------------------------------------------------HHH----HHHHHHHHHHHHHHHH-- CPSF7_2 psspred ------------------------------HHH-----------------------------------------------EEEEEE--------HHHHHHHHHHH------EEEEEEE--------EEEEEE--HHHHHHHHHH----------EEEE--------HHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHH------HHHHHHHH----------HHHHHHHHHHHHHH---H-HHHHHHHHHHHHHHHHHHHHHH----------HHHHHHHH------HHHHHH-H-HHHHHH---HHHHHHHHHHHHHHHHHHH--- CPSF7_2 spineX ---------EE-----------------------------------------------------------------------EEEE---------HHHHHHHH-------EEEEEEEE--------EEEEEE--HHHHHHHHHH----EE----EEE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHH--------------------------------------------------------------------------------------------- CPSF7_2 raptorxss ----------------------------------------------------------------------------------EEEEE-------HHHHHHHHHH------EEEEEEE--------EEEEEEE--HHHHHHHHHH--HHHH-----E-E-----------HH-------HH--------------------------------------------------------------------------------------------------------------------------------------------------H----------E--------------------------HHHH------------------HHHHHHHHHH---------------------------------------HHHHHHH-HHHHHHHH---HHHH---- CPSF7_2 SPARROW -------E--------------------------------------------------------------------------EEEEE-------HHHHHHHHHHH---EEEEEEEEEE-----EEEEEEEEE--HHHHHHHHHHH----------EE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-----------HHH---------- CPSF7_2 *SPARROW ------EEEEEE-------HHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHH----------HHHHH---------EEEEEE-------HHHHHHHHHHH--EEEEEEEEEE------EEEEEEEEEEEHHHHHHHHHHH---EE----EEEEEE-HHHHHHHHHHHHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHH--EEEHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHH---------------HHHH---HH----HHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHH CPSF7_2 HMMSTR ------EEEE----------H--------HHHH-----------------------------------EEEEEE------EEEEEE--------HHHHHHHHHH-----EEEEEEEEE--------EEEEEE--HHHHHHHHHH-----------E------HHHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHH------HHHHHHHHH-------HHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHH-HH-------------------------------HHHHHHH-------HHHHHHHHHHHHHHHHHH---- CPSF7_2 porter -----EEEEE--HHHHHHHHHHH---------EEEEE-----HHHHHHH---------------------------------EEEEE-------HHHHHHHH-------EEEEEEEE----------EEEEE--HHHHHHHHHHH---------HHHHHH--------HHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH----------------------------HHHHHH-------------HHHHHHH------------------------------------------------- CPSF7_2 cdm -----EEEEE--HHHHHHHHHHH---------EEEEE-----HHHHHHH-----------------------------------EEE-------HHHHHHHHH--------EEEEEE------EEEEEEEE-------HHHHHH----EE--EE-EEE---HHHHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH----------------------------HHHHHH-------------HHHHHHH------------------------------------------------- CPSF7_2 fdm -------EEE--------------------------------------------------------------------------EEE-------HHHHHHHHH--------EEEEEE------EEEEEEEE-------HHHHHH----EE--EE-EEE---HHHHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------HHH--------------------------------------------------------------------------------------------------------------------------------- CPSF7_2 gor -----HHHH------------------------------------------------------------EEE---------EEEEEE-------HHHHHHHHHH---E-EEEEEEEEE------EEEEEEEE--HHHHHHHHHH---------EE-----------HHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHH------HHHHHHHH--------HHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHH-HH-------------HHH-----------HHHHHHHHHH-------HHHHHHHHHHHHHHHHHHHH--- CPSF7_2 spine ------HHHHH---------------------------------------------------------EEEEE--------EEEEE--------HHHHHHHHHH-----EEEEE-------------EEEEEE----HHHHHHH--------------------HHHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHH-------HHHHH---------HHHHHHHHHHHHHHH---------EEEEE--------------------------------------------HHHHH-------HHHHHHHHHHHHHH-------- CPSF7_2 nnssp ------EEEEE---------------------------------------------------------EEEEE-------EEEEEE---------HHHHHHHHHH----HHHHHHHHHHH------EEEEEEE-HHHHHHHHHH-----------------HHHHHHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHH-----HHHHHHHH-------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------------------------HHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHH-- CPSF7_2 pssfinder ------EEEEEE--------------HHHHHHHHHH---------------------------------EEEE----------EEE--EEEE----HHHHEEEE-EEEEEEEEEEEE---------EEEEEEE----HHHHHHH----------------HHHHHHHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHHH---------HHHHHH----------------------------------------HHHHHHH-------HHHHHHHHHHHHHH-------- CPSF7_2 sspal --------------------------HHHHHHHHHHH-------------------------------EEEEEEE--------EEEEEEE------EEEEEEE--EEEEEEHHHHHHHHH------HHHHHHHHHHHHHHHHHH---EEEE-----HHHHHHHHHHHHHHHHH-----------------------------------------------------------------EEEEEEEE-----EEEEEEE--------EEEE---------------------EEEE-------------------------EEEEHHHHHHHHH------------------HHHHHHHHHHHHHHH-------------EEEEEHHHHH---------EEEE-----------------------HHHHHHHHH---HHHHHHHHH---------------- CPSF7_2 ssp -------EEEE------------------------------------------------------------------------EEEE-------HHHHHHHHHH--------EEEE-----------EEEEE--HHHHHHHHHHH-----------EE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH---------------HH--------------------------------------------------------------------------------------------------- CPSF7_2 sspred ----------------------------------------------------------------------------------EEEEE-------HHHHHHHHHH------EEEEEEE--------EEEEEEE--HHHHHHHHHHH---------EEEEE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- CPSF7_2 netsurfp -----------------------------EE--------------------------------------------------EEEEEE-------HHHHHHHHHHH-----EEEEEEE---------EEEEEE--HHHHHHHHHH----------EEEE---------HHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------EE---E------------------HHHHHHHH----------HHHHHH-HHHHHHHHHHHH-----------------------------------------------HHH-------------- CPSF7_2 soprano ----------------------------------------------------------------------------------EEEEE-------HHHHHHHHHH------EEEEEEE---------EEEEEE--HHHHHHHHHH-----------EE---------HHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHH--------HHHHH---------HHHHHHHHHHHHHHH-----------------HHH------------------------------------------------------HHHHHHHH---------- CPSF7_2 consensus MYAVYKQAHPPTGLEFSMYCNFFNNSERNLVVAGTSQLYVYRLNRDAEALTKNDRSTEGKAHREKLELAASFSFFGNVMSMASVQLAGAKRDALLLSFKDAKLSVVEYDPGTHDLKTLSLHYFEEPELRDGFVQNVHTPRVRVDPDGRCAAMLVYGTRLVVLPFRRESLAEEHEGLVGEGQRSSFLPSYIIDVRALDEKLLNIIDLQFLHGYYEPTLLILFEPNQTWPGRVAVRQDTCSIVAISLNITQKVHPVIWSLTSLPFDCTQALAVPKPIGGVVVFAVNSLLYLNQSVPPYGVALNSLTTGTTAFPLRTQEGVRITLDCAQATFISYDKMVISLKGGEIYVLTLITDGMRSVRAFHFDKAAASVLTTSMVTMEPGYLFLGSRLGNSLLLKYTEKLQEPPASAVREAADKEEPPSKKKRVDATAGWSAAGKSVPQDEVDEIEVYGSEAQSGTQLATYSFEVCDSILNIGPCANAAVGEPAFLSEEFQNSPEPDLEIVVCSGHGKNGALSVLQKSIRPQVVTTFELPGCYDMWTVIAPVRKEEEDNPKGEGTEQEPSTTPEADDDGRRHGFLILSREDSTMILQTGQEIMELDTSGFATQGPTVFAGNIGDNRYIVQVSPLGIRLLEGVNQLHFIPVDLGAPIVQCAVADPYVVIMSAEGHVTMFLLKSDSYGGRHHRLALHKPPLHHQSKVITLCLYRDLSGMFTTESRLGGARDELGGRSGPEAEGLGSETSPTVDDEEEMLYGDSGSLFSPSKEEARRSSQPPADRDPAPFRAEPTHWCLLVRENGTMEIYQLPDWRLVFLVKNFPVGQRVLVDSSFGQPTTQGEARREEATRQGELPLVKEVLLVALGSRQSRPYLLVHVDQELLIYEAFPHDSQLGQGNLKVRFKKVPHNINFREKKPKPSKKKAEGGGAEEGAGARGRVARFRYFEDIYGYSGVFICGPSPHWLLVTGRGALRLHPMAIDGPVDSFAPFHNVNCPRGFLYF CPSF1_1N sequence --EEEEEEE------EEEEEEEE-----EEEEE---EEEEEEEE---------------------EEEEEEEEEEEEEEEEEEEE-------EEEEEE---EEEEEEEE-----EEEEEEEEE----------------EEEE-----EEEEEEE--EEEEEEEE---HHHH----------------EEEE---------EEEEEE--------EEEEEEEE-------EEEEEEEEEEEEEEEE---EEEEEE------------EEEE-----EEEEEEE-EEEEEE-----EEEE-------------------EEEEEEEEEEEEE--EEEEEE----EEEEEEEE---EEEEEEEEEE--------EEEEE---EEEEEEEE--EEEEEEEE--------HH------------------------------------HH-------------EEEEEEEEEE-------EEE-------------------EEEEEE-------EEEEE-----EEEEEEE-----EEEEEE----------------------------------EEEEEEE--EEEEEE--EEEEE----------EEEEEEE----EEEEEE---EEEEE----EEEEE------EEEEEE---EEEEEEE--EEEEEEEEE------EEEEE-----------EEEEEEEEE----EE----------------------------------HHH------------HH----------------------EEEEEEE---EEEEEE-----EEEEE-------------------------HHHHH-------EEEEEEEE--------EEEEEE--EEEEEEEEE----------EEEEEEE-------------------------------EEEEEEEE-----EEEEEE-----EEEEEE----EEEEE------EEEEE----------EEE- CPSF1_1N psipred ---EEE--------EEEEEEEEE-----EEEEEE--EEEEEEEE--------------------EEEEEEEEEEEEEEEEEEEEEE------EEEEEE---EEEEEEE------EEEEEEEEE----------------EEEE-----EEEEEE---EEEEEEEE----------------------EEEEEE---------EEEEEEE------EEEEEE---------EEEE--EEEEEEEEE-------EEEEE----------EEE-------EEEEEE-EEEEEE-------EEE------------------EEEEEE-EEEEE---EEEEEE----EEEEEEEE----EEEEEEEEE--------EEEEE---EEEEEE-----EEEEEE---------------------------------------------------------------EEEEEE-------------------------------EEEEEEE-----HHHHHHHH----EEEEEEE------EEEEEE--------------------------------EEEEEEE---EEEEEE--EEEEE----------EEEEEE----EEEEEEE----EEEE----EEEEE------EEEEEE---EEEEEE---EEEEEEE-----------------------EEEEEEEEE-------------------------------------------------------------------------------EEEEEEEE---EEEEEE-----EEEEEE-------------------------------------EEEEEE---------EEEEEE---EEEEEEE----------EEEEEEEE----------------------------------EEEEE------EEEEEE-----EEEEE----EEEEE------EEEE------------EE- CPSF1_1N prof --HHHHH-----HHHHEEEEE-------EEEEE---EEEEEEEE--------------------EEEEEEE-----EEEEEEEEE------EEEEEE----EEEEEE--------EEEEEEEE----------------EEEEE----EEEEEE---EEEEEE--------------------------E--------------EEEE-------EEEEEE---------EEE----EEEEEEEE--------EEEE----------E--------EEEEE---EEEEE-------EEE-------------------EEEE---EEEEE---EEEEEE----EEEEEEEE---EEE-------------EEEEEE----EEEEEEE---EEEEEEE---------------------------------------------------------------EEEEEEEEE-------EEEEE----------------EEEEEEE------EEEEEE-----EEEEEEE-----EEEEEE----------------------------------EEEEEE---EEEEEE-----E-----------EEEEE------EEEEEE---EEEE----EEEEEE------EEEEEE---EEEEEE----EEEEEEE------EEEEE------------EEEEEEEE-----EEE------------------------------------------------------------------------EEEEEEE----EEEEE----EEEEEE-------------------------------------EEEEEEE--------EEEEEEE---EEEEEE------------EEEEEE------------------------------------EEEE------EEEEEE---EEEEEEE----EEEEE------EEEE------------E-- CPSF1_1N jnet -EEEH--------EEEEEEEEE------EEEEE---EEEEEEE---------------------EEEEEEEEE----EEEEEEE--------EEEEEE---EEEEEEE------EEEEEEEE-----------------EEEE-----EEEEEE---EEEEEEE------HH-----------------EEE---------EEEEEEEE-------EEEEEE--------EEE----EEEEEEEE---------E------------EE--------EEEEE--EEEEE-------EEE-------------------EEEEEEEEEEE----EEEEEE----EEEEEEEE----EEEEEEEEE--------EEEEE---EEEEEE-----EEEEEE----------------------------------------------------------------EEEEE----------EEEE-------------------EEEEE------EEEEE------EEEEEEE-----EEEEEE----------------------------------EEEEE-----EEEE------------------EEEEEE-----EEEEEE---EEEEE----EEEE------EEEEEEE---EEEEEE----EEEEEE----------EEE----------EEEEEEE----------------------------------------------------------------------------------EEEEEE----EEEEEE-----EEEEE-----------------------------------HHHHHHHEE---------EEEEEE---EEEEEEE-----------EEEEEEE----------------------------------EEEE--------EEEEE----EEEEEE----EEEE------EEEEEE----------EEEE CPSF1_1N sable -EEEEEEE-----EEEEEEEEE-----EEEEEE---EEEEEEE---------------------EEEEEEEEEEEEEEEEEEEEE------EEEEEEE----EEEEEE-----EEEEEEEEE----------------EEEEE-----EEEEEE---EEEEEEE---------------------EEEEEEEEEE-------EEEEEE-------EEEEEEE---------------EEEEEEEE---------------------EEEE------EEEEEE--EEEEEE----EEEEE------------------EEEEEEEEEEEE----EEEEEE----EEEEEEEE----EEEEEEEEE-------EEEEEE---EEEEEE----EEEEEEE--------------------------------------------------------------EEEEEEEEEE------EEEEEEE---------------EEEEEEEE-----EEEEEE----EEEEEEEE-----EEEEEEE--------------------------------EEEEEEE---EEEEEE----EEEE--------EEEEEEE-----EEEEE---EEEEEE---EEEEEE-----EEEEEEE---EEEEEE----EEEEEEE----------EE----------EEEEEEEE-----EEEEE-----------------------------------------------------------------------EEEEEE----EEEEEE----EEEEEE-------------------------------------EEEEEEEE-------EEEEEEE---EEEEEEEE----------EEEEEEE--------------------------------EEEEEEE------EEEEEE----EEEEEE----EEEEEE----EEEEEEEE-------EEEE- CPSF1_1N proteus ---EEE--------EEEEEE--------EEEEEE--EEEEEEE-------E------------EEEEEEEEE---EEEEEEEEE--------EEEEE----EEEEEEE-------EEEEEEH-----------------EEEE-----EEEEEEE--EEEEEE---H---------------------EEE-HHH-------HEHHHHH------EEEEEEE--------EEEEEEEEEEEEEEEE-------EE-----------EEEE------EEEEEEEEEEEEE-------EEEE-------------------EEEEEEEEE-----EEEEE-----EEEEEEEE---EEEEEEEEEE-------HHEEEE---EEEEEE-----EEEEEE-------HHHHHHH-------HHH----------------------------------EEE--EEEEEHHHH------E---------HHH----------EEEEE--------EEEEE-----EEEEEE-------EEEEE----------------------------------EEEEEEE--EEEEE---EEEEEE---------EEEEEE-----EEEEE----EEEE----EEEE-------EEEEEEE---EEEEEEE--EEEEEEEE--------EEEEE----------EEEEEEEE-----EEEE-----------------H-------------HHHH------------HHHHHH------------------EEEEEEE---EEEEEE----EEEEEE--------EEE---------HHHHHHHHHHH------EEEEEEEE--------EEEEEE--EEEEEEE------------EEEEEE---------------------------------EEEEEEE------EEEEE-----EEEEEE-----EEEE-------H-------------EEE- CPSF1_1N sspro4 --EEEEEE-----EEEEEEEEE------EEEEEE--EEEEEEEE--------------------EEEEEEEEEE--EEEEEEEEE------EEEEEEE---EEEEEEEE-----EEEEEEEE-----------------EEEE-----EEEEEEE--EEEEEE-------------------------EEEEE--------EEEEEEE-------EEEEEEE------HHHHEEE-EEEEEEEEEE---EEEEEEEEE---------EEE------EEEEEE--EEEEEE-----EEEE-------------------EEEEEEEEEEEE---EEEEEE----EEEEEEEE---EEEEEEEEEE--------EEEEE---EEEEEE----EEEEEEEE-----------------------HHH------------------------------------EEEEEEEEE------EEEEEE------HHH--------EEEEEEE-----EEEEEE-----EEEEEEE-----EEEEEE----------------------------------EEEEEE---EEEEEE---EEEEE---------EEEEEEE----EEEEEE--EEEEEE----EEEEE-----EEEEEEEE--EEEEEEE--EEEEEEEE-------EEEEE-----------EEEEEEE-----EEEE------------------------------------------------------------------------EEEEEEE---EEEEEE----EEEEEE--------EE---------------------------EEEEEEEE-------EEEEEEE---EEEEEEEE----------EEEEEEE----E-----------------------------EEEE--------EEEEE----EEEEEE-----EEEE------EEEE------------EE- CPSF1_1N psspred -EEEEEEE-------EEEEEEE-----EEEEEE---EEEEEEEE---HHH---------------EEE-EEEEE--EE-EEEEEE------EEEEEEE---EEEEEEEE----EEEEEEEEE-----------------EEEEE----EEEEEEE--EEEEEE-----HHHHHHHHH----------EEEEE---------EE-EEEEE------EEEEEEE--------EEEEEEEEEEEEEEE-----------EE---------EE--------EEEEE--EEEEEE------EEE-------------------EEEEEEEEEEEE---EEEEEE---EEEEEEEEE--EEEEEEEEEEE--------EEEEE---EEEEEEEE--EEEEEEE-------HHHHHHHHH----HHHHHHHHHHHHH-H-------------EEE-----------EEEEEEE---------------------H---------EEEEEEE------EEEEEE----EEEEEEEE-----EEEEEEE-------------------------------EEEEEEE----EEEEE----EEEE----------EEEEEEE---EEEEEEE---EEEEE---EEEEE------EE-EEEE---EEEEEE---EEEEEEEEE-------EEEEE----------EEEEEEEEE----E----------------------------------HHHHH-----------HHHHH------------------EEEEEEEE---EEEEEE----EEEEEE-------EEE----------HHHHHHHHHH-------E-EEEEEE-------EEEEEEE--EEEEEEEEE---------EEEEEEEE---------------------------------EEEEEE-----EEEEEEE----EEEEEE----EEEEE-----EE-EEE----------EEEE CPSF1_1N spineX --EEEEEE-----EEEEEEEEE------EEEEE---EEEEEEEE-------------------EEEEEEEEEEE--EEEEEEEEE-------EEEEEE----EEEEEE------EEEEEEEEE----------------EEEE-----EEEEEE----EEEEEE-----EEEEEEEE-------EEEEEEEEEE-----EEEEEEEEEE------EEEEEEEE-----EEEEEEEEEEEEEEEEEE--------E-----------EEEEE-----EEEEEEE-EEEEE------EEEE------------------EEEEEEEEEEEEE---EEEEEE----EEEEEEEE----EEEEEEEEE---EEEEEEEEEE---EEEEEEEE---EEEEEEE-------EEEEE------------EE------EEEEEEE------EEEEE----EEEEEEEEEEEEEEEEEEEE--EEEEEEE-----------------EEEEEE------EEEEEE-----EEEEEEE-----EEEEEEE-----EEE--EEEEEEEE--------------EEEEEEE---EEEEEE---EEEEE---------EEEEEEE----EEEEE---EEEEEE---EEEEEE-----EEEEEEE---EEEEEE----EEEEEEE----EEEEEEEEEE--------EEEEEEEEE---EEEEEEEEEEEEE--EEEEE-------------E----EEEEEE-----E------EEEEE----------------EEEEEEE---EEEEEE-----EEEEEE-----EEEEE--------EEEEEEEEEEEEE-----EEEEEEEEE-------EEEEEE---EEEEEEEE---------EEEEEEE-----E----------------EEE--------EEEEEEEE----EEEEEEE----EEEEEE---EEEEEEEEE---EEEE------------E-- CPSF1_1N raptorxss --EEEE-EE----EEEEEEEE-------EEEEE---EEEEEEEE---------------------EEEEEEEEEEEEEEEEEEEE-------EEEEEE---EEEEEEEE-----EEEEEEEE-----------------EEEE-----EEEEEEE--EEEEEEE-----HHHH----HHH-------EEEEEHHH-------EEEEHH--------EEEE------------EEEEEEEEEEEEE-----EEE-------------EEEEE------EEEEE--EEEEEE------EEE-------------------EEEEEEEEEEE----EEEEEE----EEEEEEEE---EEEEEEEEEE--------EEEEE----EEEEE----EEEEEEEEE---------------------------H---------------------------------EEEEEEH--------EEEEEEE-----HHH--------EEEEEE-------EEEEE----EEEEEEEE-----EEEEEE----------------------------------EEEEEE---EEEEEE---EEEE----------EEEEEEE----EEEEEE---EEEEE----EEEEE------EEEEEEE--EEEEEEE--EEEEEEEE-------HHHEE---H---H---EEEEEEEE-----EE-HHHHHH------------------------------E----------------------------------EEEEEEEE---EEEEEE----EEEEEE--------------------HHH--------------EEEEEEEE-------EEEEEEE--EEEEEEEEE-----------EEEEEE-----------------------------------EEE--------EEEEE----EEEEEE----EEEEEE-----EEEE--E--------EEE- CPSF1_1N SPARROW ---EEE-E-----EEEEEEEEE------EEEEEE--EEEEEEE----------------------EEEEEEEEE--EEEEEEEEE-------EEEEEE---EEEEEEEE----EEEEEEEEEE----------------EEEE-----EEEEEE---EEEEEE---------------H---------EEEE---------EEEEEEE--------EEEEEE--------EEEEE--EEEEEEEE-----EEE--------------EEE-------EEEEE--EEEEE------EEEEE------------------EEEEEEEEEEE----EEEEEE----EEEEEEEE---EEEEEEEEEE---------EEE-----EEEEEE----EEEEEE-----------------------------------------------------------------EEEEEEE---------EEE------HHH--------EEEEEE------EEEEEE----EEEEEEEE-----EEEEEE-----------------------------------EEEE----EEEEE-----EEE----------EEEEEEE----EEEEEE--EEEEEE----EEEEE------EEEEEEE--EEEEEEE--EEEEEEEE-------EEEE------------EEEEEEEE-----EE-------------------------------------------------------------------------EEEEEEE---EEEEEE----EEEEEE-------------------------------------EEEEEEEE-------EEEEEEE---EEEEEEEE-----------EEEEE---------------------------------EEEEEEE-----EEEEEEE----EEEEEE----EEEEEE-----EEE------------EEE- CPSF1_1N *SPARROW EEEEEEEE------EEEEEEEEE-----EEEEEHHHHHEEEE--------------------H-EEEEEEEEEEE--EEEHHEEEEE-----EEEEEEEEEEEEEEE----H--EEEEEEEE--H-------------EEEEE-----EEHHHHHHHHEEEEE--HHHHHHH-------H-------EEEEEHHHHHHHHHHHHHEEEE-------HHHHHHHHHHHHHHHHHHHHEEEEEEEEEEHHHHHEEEEEE----------EEE-------EEEEEEEEEEEE-----EEEE-----------------HH-EEEEEHHHHHHE--EEEEEE-----EEEEEEEE----EEEEEEEEE-------EEEEEE----EEEE------EEEEHHHH--------HHH--------------------------------------------------EEEEEEHHHHH------EEEE------HHH--------EEEEEE-------HEEHHH---HHEEEE-------EEEEEEE--------------------------------EEEEEE----EEEEEEHHHHHHHHH--------EEEEEE-----EEEEEE----EEEE--H-EEE-------EEEEEE----EEEEE-----EEEEEE-----HHHHHHHHHHHHHHH---EEEEEEEEE-----EE------------EEEE---HHHHH---------HHHHH----HHH----------------------------EEEEEE----EEEEEE----EEEEEEE---H-HHHHHH--------H-H-------HHHHHHHHHHHHHHHH-------EEEEEE---EEEEE-E----------EEEEEEH--H--EE----------------HHHHHHHHHHHHHHHHHH------EEEEE----EEEEE-----EEEE--EE--EEEEEE-----------EEE CPSF1_1N HMMSTR --EEEEEEE-----EEEEEE--------EEEEEE--EEEEEEE---------------------EEEEEEEEE----EEEEEEE--------EEEEEE---EEEEEEE-------EEEEEEEE---------EEE-----EEE-----EEEEEEE--EEEEEE-----HHHHH--------------EEEEEE---------EEEEEEE------EEEEEE--------EEEEEEEEEEEEEEEEE----EEEEEEEEE-------EEEE-------EEEE----EEEEE-------EEE-----------------EEEEEEEEEE------EEEEEE---EEEEEEEEE----EEEEEEEEEE-----EEEEEE----EEEEE-----EEEEEEE--------HHHHH-----------EEE--------------------EEEE-----------EEEEEEEEEE-----EEEEEEE---HHHHH--------EEEEEEE------EEEEEE-----EEEEEEE-----EEEEEE----------------------------------EEEEEE---EEEEEE--EEEEE----------EEEEEEE----EEEEEE---EEEE---EEEEEE--------EEEEE---EEEEEE----EEEEEEE--------EEEEEE---------EEEEEE----EEEEE----------------------------------HHEE-----------HHHHHH------------------EEEEEEE----EEEEE----EEEEEEE------EEEEE------------HHHHHHH------HEEEEEEE--------EEEEEE--EEEEEEEEE---------EEEEEEE-----E--------------------------EEEEEEEEEE----EEEEEE----EEEEEEE---EEEE----------------------EEE- CPSF1_1N porter -EEEEEE-------EEEEEEE-------EEEEEE--EEEEEEE-----EE--------------EEEEEEEEEE---EEEEEEEE------EEEEEEE---EEEEEEE------EEEEEE-------------------EEEE-----EEEEEEE---EEEEEE----HHHHH--------------EEEEE--E-------HHHHHHH-------EEEEE---------EEEEE-EEEEEEEEEE----E--EEEEE--------E-EE-------EEEEE--EEEEEE-------EE--------------------EEEEEEEEEE----EEEEEE----EEEEEEEE--EEEEEEEEEE---------EEEEE---EEEEE-----EEEEEEE-------HHHHHEH--------HHHHHHHHH-----------------EEE-------------EEHHHHHHH-------EEE-------HHH-------EEEEEEE------EEEEEE-----EEEEEEE-----EEEEEE---------------------------------EEEEEE----EEEEE---EEEE-----------EEEEEE-----EEEEE----EEEEE---EEEEE------EEEEEEE---EEEEEE---EEEEEEEE-------EEEEEE----------EEEEEEEE-HHHHH-HHH------------------------------HHHHH-----------HHHHH------------------EEEEEEEE----EEEEE----EEEEEE--------------------HHHHHHHHHH-----HHHEEEEEEE--------EEEEEE---EEEEEEEE---------EEEEEEE-----------------------HHH----------EE--H-H----EEEE-----EEEEEE------EEEE-----E--E-----------E--- CPSF1_1N spine HHHHHHH--------EEEEE---------EEE----EEEEEEE---HHHHHH---------HHHHHHHHHHHHH------HHHHHHH------EEE------EEEEE---------EE----------------------EE-------EEEEEE---EEEE----HHHHHHHH---------------EE-HHHHHHHHHHHHHHHHH-------EEEEE---------EEE-----EEEEE----------EEEEE-------------------EEEEE------------------------------------EEEE------EE----EEEEE----EEEEEEE-----HHHHH-------EEEE--EEE----EEEE------HHHHHHHHHH----HHHHHHHH---------------------------------EE---------HHHHHHHHHH--------------------------------EEEEE-------HHHHHH------EEEEE--------EEEE----------------------------------EEEEE----EEEE---HHHHHH----------EEEE-------EEEE-------------------------EEEE-----EEEEEE----EEEEEE-----------EE-----------EEEEEEE-----------------------------------------HHHHH-----------HHHHHH-------------------EEEEE-----EEEE-----EEEEEE-------EEEE-----------HHHHHHHHH---------EEEE---------EEEEE----HHHHH------------EEEEE------------------------------------HHHHHHH-------EEEE-----EEEE--------------------------------EE- CPSF1_1N nnssp --HHHHHH-----EEEEEEEEEE-----EEEEE---HHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---EEEEEEE------HHHHHHHHHH-HHHH----------EEEE-----EEEEEEE--EEEEEE--HHHHHHHH-------------------HHHHHHHHHHHHHHHHH-------EEEEE--------EEEEEE--EEEEEEEE--------EEEEE------HHHH---------EEEEEE--EEEE--------EEE------------------EEEEE----------EEEEEEE--EEEEEEEEE-HHHHHHHHHHHHHHHHH----EEEE---EEEEE----HHHHHHHHHH-----HHHHHHHHHH------------------------HHHHHHHHHH--------------HHHHHHHH-----------------HHHHH-----EEEEEEE-----------------EEEEEEE------------------------------------------EEEEEEEEHHHHHHHHHHHHHHHHH----------EEEEEEE--EEEEEEE-HHHHHHHH---EEEEEE------EEEEEE----EEEE-----EEEEEEE-----------------------EEEEEEEE----------------------------------------HHHHHH----------HHHHHH------------------EEEEEEE---EEEEEE----EEEEEEE------EEEEE--------HHHHHHHHHHHH--HHHHHHHHHHHH-------EEEEE--HHHHHHHH-----------EEEEEEE-----------------------HHHHHHHHHHHHH-HHHHHHH----EEEE-----EEEEE-HHHHHH--------------------------- CPSF1_1N pssfinder HHHHHHH-------EEEEEEEEE------EEEE----EEHHHH-HHHHHHHHH---------HHHHHHHHH------HHHHHHHHH-------EEE-------EEEE-------HHHHHH-----------EEE-----EEEE------HHHHH----EEEEE---HHHHHHHHHHH---------------HHHHHHHHHHHHHHHH-------EEEEE---------EEHHH----EEEEEE---------EEEEEE-----HHHHH--------EEEEEE-------------------------EE-------EEEEE----------HHHEEE-----EEEEEEE------HHH----HHHHHH-----EE----EEEE------HHHHHHHHHH----HHHHHHHHH---------HHH-------------HHHHHHHHEEEE-------HHHEEHHHH-HHH----------------HHHH--------EEEEEE------HHHHHHH-----EEEE--------HHHHHHHHHH---------------------------EEEEEEE-----HHHHHHHHHHHH----------EEE--------EEEEE----HHH-----EE----------EEEE-----EEEEEE----EEEEEEE-------EEEEEE---------EEEEEE-------EE---------------------------------HHHHHH-----------HHHHH--------------------EEEEE-----EEEE-----EEEEEE------EEEEE-----------HHHHHHHHHH------HHHHH----------EEEEE--HHHHHHH-------------EEEEE-------------------------------------HHHHHHH-----EEEE------EEEE------------------------------EEEE CPSF1_1N sspal HHHHHHHHH----EEEEEEE---------EEEE---EEEEEEEHHHHHHHHH-----HHHHHHHHHHHHH-EEEE--HHHHHHHHHH-HHHHHHHHH-----EEEEEEE-------EEEEEEE-HHHHHHHHHH-----EEEE------------EEEEEEHHHHHHHHHHHHH-----------HHHHHHHHHHHHHHHHH-------------EEEEEEE--------------EEEEEEE----------EEEEEEE--------------EEEEEEEEE--EEEE------EEEEE-----------------EEEEEEE---------EEEEEEE---EEEEEEEE----------HHHHHHHEEEEEEEE----EEEE-----HHHHHHHHHHHHH--HHHHHHHHH-------------------------HHHHHHEEEE-----------EEEEEEE-----------------HHHHHHHHH-----EEEEEEE------HHHHHHHHHH--EEEEEEE----HHHHHHHHHHHHHH--------------------------EEEE--------HHHHHHHHHH----------EEEE------EEEEEEE---HHHHHHHHHHEEEEE-----EEEEEEE--EEEE------EEEEEEE-----------------------EEEEEEE-----EEEE------HHHHH---------------------HHHHH----------------------------------EEEEEEE--------------EEEEEEE-------EEEE----------HHHHHHHHHH----HHHHHHHHHH-------EEEEEEE-------------------EEEEEEEE--------------------------------EEEEEEE----EEEEEEEE----EEEEEEE--------EEEE--------------------- CPSF1_1N ssp ----EEE-----------------------EEE-----EEEEE----------------------EEE-EEEEEH---EEEEEE--------EEEEE----EEEEEEEE-----EEEEEHH------------------EEEE-----EEEHHHHH-EEEEEEEE------HH---------------EEEE------------EEEEE-------EEEE----------------------EE--------------------------------EEE-------EEEE-----------------------------EEE---EEEE----EEEEEE----EEEEEEE------EEEEEHH-----------EEEE--EEEEEE----EE-EEEE--------------------------------------------------------------------HE---------EEEEEE-----------------EEEE---------------------EEE--------EE-----------------------------------EEEEEEE----EE------EHH-----------EEEEE-------EEEE---EEEEE-----EEEE------EE--EEE---EEEEEE---EEEEEE---------------------------EEEEH--HHHHHEEH------------------------------------------------------------------------EEEE------EEEEE----HEEE-------------------------HHHHHH---------------------------EE---------------------------------------------------------------------------EEE------------------------------EE-------------- CPSF1_1N sspred --EEEEE-------EEEEEEEE------EEEEEE--EEEEEEEE--------------------EEEEEEEEE---EEEEEEEEE-------EEEEEE----EEEEEEE-----EEEEEEEE-----------------EEEE-----EEEEEE----EEEEEE------------------------EE------------EEEEE-----------EEE-----------EE--EEEEEEEE-------EEEE-----------EEEE-------EEEEE--EEEEE------EEE--------------------EEEEEEEEEEE----EEEEEE----EEEEEEEE----EEEEEEEEE--------EEEE-----EEEE------EEEEEEE-------------------HHHHHHHHHH----------------------------------EEE--------------EE------------------EEEEEEE-----EEEEEE-----EEEEEEE-----EEEEEE----------------------------------EEEEE----EEEEE------EE----------EEEEEE-----EEEEEE---EEEEE----EEEE-------EEEEEE---EEEEEE---EEEEEEEE-----EEEEEEE-----------EEEEEE----------------------------------------------------------------------------------EEEEEEE---EEEEEE-----EEEE--------------------------------------EEEEEEEE-------EEEEEEE---EEEEEEEE----------EEEEEE---------------------------------EEEEEEE------EEEEE-----EEEEEE----EEEEE-----EEEEE-----------EEE- CPSF1_1N netsurfp --EEEEEE-----EEEEEEEEEE-----EEEEE---EEEEEEEE---------------------EEEEEEEEEEEEEEEEEEE-------EEEEEEE---EEEEEEE------EEEEEEEE-----------------EEEE-----EEEEEEE--EEEEEEE------------------------EEE-----------EEEEHH-------EEEEEEE---------EEEE--EEEEEEE--------EE---E---------EE--------EEEEE--EEEEE-------EE--------------------EEEEEEEEEEEE---EEEEEE----EEEEEEEE---EEEEEEEEEE--------EEEEE---EEEEEEE----EEEEEE-----------------------HHHHH------------------------------------EEEEEEE-----------E------------------EEEEEE------EEEEEE-----EEEEEEE------EEEEEE---------------------------------EEEEEE----EEEE------E-----------EEEEEE-----EEEEEE--EEEEEE----EEEEE-----EEEEEEE---EEEEEEE--EEEEEEEE---------EEE-----------EEEEEEE-------E-----------------------------------HHH-----------------------------------EEEEEEE----EEEEE----EEEEEE--------E----------------------------EEEEEEE---------EEEEEE---EEEEEEEE----------EEEEEEE----------------------------------EEEE--------EEEEE----EEEEEE----EEEEE-----EEEEEEE---------EEE- CPSF1_1N soprano --EEEEEE------EEEEEEEE------EEEEE---EEEEEEE---------------------EEEEEEEEEE--EEEEEEEEE-------EEEEEE---EEEEEEE------EEEEEEEE-----------------EEEE-----EEEEEEE--EEEEEE-------HH----------------EEEE----------EEEEEE-------EEEEEE---------EEEEE-EEEEEEEEE--------EE-E----------EEE-------EEEEE--EEEEE-------EEE-------------------EEEEEEEEEEE----EEEEEE----EEEEEEEE----EEEEEEEEE--------EEEEE---EEEEEE----EEEEEEE---------------------------------------------------------------EEEEEEEE---------EEE-------H----------EEEEEE------EEEEEE-----EEEEEEE-----EEEEEE----------------------------------EEEEEE---EEEEE----EEEE----------EEEEEE-----EEEEEE---EEEEE----EEEEE------EEEEEE---EEEEEE---EEEEEEEE--------EEEE-----------EEEEEEEE-----EE-----------------------------------HH------------------------------------EEEEEEE---EEEEEE----EEEEEE-------------------------------------EEEEEEEE--------EEEEEE---EEEEEEEE----------EEEEEE-----------------------------------EEEEE------EEEEEE----EEEEEE----EEEEE------EEEE-----------EEE- CPSF1_1N consensus MSCVHYKFSSKLNYDTVTFDGLHISLCDLKKQIMGREKLKAADCDLQITNAQTKEEYTDDNALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPAMATTKAIDDSSASISLAQLTKTANLAEANASEEDKIKAMMSQSGHEYDPINYMKKPLGPPPPSYTCFRCGKPGHYIKNCPTNGDKNFESGPRIKKSTGIPRSFMMEVKDPNMKGAMLTNTGKYAIPTIDAEAYAIGKKEKPPFLPEEPSSSSEEDDPIPDELLCLICKDIMTDAVVIPCCGNSYCDECIRTALLESDEHTCPTCHQNDVSPDALIANKFLRQAVNNFKNETGYTKRLRKQLPPPPPPIPPPRPLIQRNLQPLMRSPISRQQDPLMIPVTSSSTHPAPSISSLTSNQSSLAPPVSGNPSSAPAPVPDITATVSISVHSEKSDGPFRDSDNKILPAAALASEHSKGTSSIAITALMEEKGYQVPVLGTPSLLGQSLLHGQLIPTTGPVRINTARPGGGRPGWEHSNKLGYLVSPPQQIRRGERSCYRSINRGRHHSERSQRTQGPSLPATPVFVPVPPPPLYPPPPHTLPLPPGVPPPQFSPQFPPGQPPPAGYSVPPPGFPPAPANLSTPWVSSGVQTAHSNTIPTTQAPPLSREEFYREQRRLKEESKSPYSGSSYSRSSYTYSKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHGYHRSRSRSPPYRRYHSRSRSPQAFRGQSPNKRNVPQGETEREYFNRYREVPPPYDMKAYYGRSVDFRDPFEKERYREWERKYREWYEKYYKGYAAGAQPRPSANRENFSPERFLPLNIRNSPFTRGRREDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKND RBBP6_2N sequence --EEEEEE-------EEEE------HHHHHHHHHHH---------EEEE-------------------EEEEEEE-----------EEE------------------HHHHHHHHHHHHHHHH---HHHHHHHHHHH--------------------------------------------------------------EE---------EE-----EEEE---HHHHHH--------------------------------------------------HHHHHHHHH-----------------------HHHHHHHHHHHHHH------------------------------------------------------------------------------------------------------------------------------HHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHH------------------------------------------------------------------------------------------------------------HHHHHH-----------------------------------------EEE--HHHHH----------------- RBBP6_2N psipred --EEEEEEE------EEEE---EE-HHHHHHHHHHHH--------EEEE-------------EE----EEEEEEE-----------EEE-------------------------------------HHHHHHHHHHHHH-------------------EEEEE------EEE-----------------------HHHHH---------EEEE----EEEEE--HHHHHHHHH----------------------------HHHH---------------HHHHHHHHH-----------------------HHHHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHH------------------ RBBP6_2N prof ---EEEEEE---------------HHHHHHHHHHHH--------EEEEE------------EEEE---EEEEEEE--------------------------------------------------HHHHHHHHHHH----------------------EEEEE------EE----------------E----------EEEE-------EEE-----EEEE---HHHHHHHHHH-----------------------------------EE----------HHHHHHH------------------------HHHHHHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEEE------------------------- RBBP6_2N jnet --EEEEEE-------EEEE---EEEHHHHHHHHHHH--------EEEEEE------------EE----EEEEEE----------------------------------------------------HHHHHHHHHH-----------------------EEEE--------------------------------HHHHH---------EEE-----EEEE----HHHHHH-------------------------------HHHHH---EE-------HHHHHHHHH------------------------HHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------EEE--------------------EEE------------------------- RBBP6_2N sable -EEEEEEE----EEEEEEEE-EEE-HHHHHHHHHHHH------EEEEEEE----EEE----EEEE--EEEEEEEEEE-------------------------------------------------HHHHHHHHHHHHHHHHH----------------EE------------------------------------------------EEE----EEEEE---HHHHHHHHHHHHHHHHHHHH--------------------------E----------HHHHHHH-------------------------HHHHHHHHHHHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEE------------------------------------------------ RBBP6_2N proteus --EEEEEE-------EEEE------HHHHHHHHHHHH---------EE-----HHH------------EEEEEE-----------HHHH--------------------HHHH----HHHHH----HHHHHHHHHHH--------HHH-----------EEE-------EEE-----------------------HHH-EE---------E------EEEE---HHHHHHH-H------HH-------------HH----HHHHH----EE---------HHHHHHHHH----------------H-H----HHHHHHHHHHHHH----------------------HHHHH------------------E-------------------------------------------EE---E---------E-------HHHH----------EEEEEH-------E--E--------------------------EE------------------------EEE---EEEEE------EEEEE------------------------------------------------------------------------EE---------------------HHHH-HH-HHHHHH--------------HEE----------EEEEE--------------------------------------------------------------------------HHHH---------HHHEEEEEEE-------HH----HHH-------------------------------HHH--------------------------------------------------------------------------------------HHH-------------------EEEE------------------EEEE-------------------------- RBBP6_2N sspro4 --EEEEEEE------EEEE------HHHHHHHHHHHH-------EEEEE-------------EE----EEEEEEE---------------------------------------------------HHHHHHHHHHH-------------------------------------------------------------------------EE-----EEEE---HHHHHHHHH---------------------HHHH-----------EE---------HHHHHHHHH------------------------HHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_2N psspred -EEEEEEE-------EEEE------HHHHHHHHHHHH-------EEEEEE------E----------EEEEEEEE----------EEE----------------------HHHHHHHHHHHHH---HHHHHHHHHHHH----------------------------------------------------------HH-EE--------EEEE---EEEEEE--HHHHHHHHH-------------------------------------E---------HHHHHHHHHH---------------HHH----HHHHHHHHHHHHHH--HH-------------------------------------------------------------------------------------------------------------HH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHH-------------------------------------------------------------------------HHHHHHH------------HHHHHHHH---------HHHHHHHH--------------------------------------------HHHHHHHH--HH---------- RBBP6_2N spineX --EEEEE--------EEEE------HHHHHHHHH-H---------EEEE-----EEE-----E-----EEEEEE-----------EEEE------------------------------HHHH---HHHHHHHHHH-----------------------EE----------------------------------HHH------------EEE----EEEEE--HHHHHH------------------------HHH------------EEE--------HHHHHHHHHH----E-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_2N raptorxss -EEEEEEE------EEEEE------HHHHHHHHHHH--------EEEEE------------EEE----EEEEE--------------E-------------------------------HHH----HHHHHHHHHHH----------------------EEE-------EEE---------------E-------HHHEEE--------EEEE----EEEE---HHHHHHHHHHH-------------HH---------HH---HH---EE---------HHHHHHHH------E----------H------HHHHHHHHHHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHH---------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHH----------------------------------------------------------------H----------H-HH------------HHHHH--------------HHH---HH---------------EEEE-------------------------HHHHHH---------HHH---- RBBP6_2N SPARROW --EEEEEE-------EEEE----E-HHHHHHHHHHH--------EEEEE-------E-----E-----EEEEE-------------E---------------------------------------HHHHHHHHHHH-------H--------------------------------------------------HHH-----------EEE-----EEEE---HHHHHHHHHH-----------------------------HH---------------HHHHHHHHHH----E-----------------HHHHHHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_2N *SPARROW --EEEEEEEE-----EEEEE--EEEEHHHHHHHHHHHH-----EEEEEE------EE-----E-----EEEEEE------------EEEE--------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--HH----------------H--H---EEEE------------HHHHHH-----HHHHHEE-------EEE-----EEEE---HHHHHHHHHHHHHHHHHH----HH------HHHH-HHHHHHHH---EE---HHHHHHHHHHHHHHHH-----HH-H-----H-H-E-HHHHHHHHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHH----------------------------------------------------------------------------------------HHHH---------------------------HHHHHHHHHHHHHHHHHHHHH------------------------------------------------------------------------------------------HHHHH-----------HHHHHHHHH-------HH-----EEE------------------EEEEE---HHHHHH--------HHHHHHHH RBBP6_2N HMMSTR -EEEEEEE-----EEEEEE---EEEHHHHHHHHHHHH------EEEEEEE-----EE-----EEE----EEEEEEE----------EEE--------------------E----------------HHHHHHHHHH----------------------------------HHH--HHH---------------------------------------EEE----HHHHHHH-----------------------HHH------------EE------EE---HHHHHHHH----------------------HHHHHHHHHHHHH----HHHH--------------HHHHH------------------------------------------------------------EEEEEEEE-----------------HHHHHHHH------HHHHHHHHHH------------------------------EE--------------------E-----H---------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHH-----------------------------------------------------------------------------------------H----------------HHHHHHHH---------HHH---------HHHHHHHHHHHHHHHHHHHHHHHHHH--------------------------------------------------------------------------------------------------------HHHHHH-----------------EEE------------------------------------------------ RBBP6_2N porter --EEEEE---------EE----EEEE-------------------EEE---------------------EEEEEE----------EEEEE--------------------HHHHHHHHHHHHH------HHHHHHH------------------------EE----------------------------------EEEEE---------EEE---------------------------------------------EEE-------EEEEE-----------HHHHH------------------HHHHHHHHHHHHH------------------------------------------------EEEE------------------------------------------EEEEEE------------------HHHHH--------EEEEHHHHH------EE-----------------------EE-------------------EEE----------------------------------------EE--------------------------------------------------------------------------------HHHHHHHHHHHH----------------EEE---------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------EEEE------------------EEEEE------------------------ RBBP6_2N nnssp ---------------EEEE--EEEEHHHHHHHHHHHHHHHH----EEEE-------------------EEEEEE------------EEEEE--HHHHHHHHHH-------HHHHHHHHHHHHH---HHHHHHHHHHH----------------------------------------------------------HHHHHHH------EEEEE-----------HHHHH-------------------------HHHHHHHHHHH----EEEE-------HHHHHHHHHH---------------HHHHHHHHHHHHHHHH--------HHHHHH---------------------------------EEEEE--------------------------------------EEEEEEEEEEE---------------HHHHHHHHH-----HHHHHHHHHHH---------HHHHHHHHHH---------EEEEEE-------------------------------EEEEEE--------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHH--------------EEEEE---------------------------------------------------------------------------------------HHHHHHH----------------------HHHHHHHHHHHHHHHHHHHH---------------------HHH--------------------------------------------------------------------------------------HHHHHHHHH-------------EEEEEE------------------------HHHHHHH--------------- RBBP6_2N pssfinder ---EEEEE-EEEE---------EE------EEE-------EEE--EEEEE-EEEHHHH---------EEEEEEEEEE-------EEEEEE--------------------HHHHHHHH-HHHH---HHHHHHHHHH-----------------------EEEE----------------------------------EEEEEE-------------EEEEEE-HHHH-----------------------------EEEEE-----EEEEEEE-----HHHHHHHEEEE--------------------HHHHHHHHHHHHH------HHH--------------------HHHH--------------EEEE------------EE--------------------------EEEEEE-------------------HHHHH--------HHHHHHHHHH-----------EE--EE----EE------EEEE-------------------------------HHHH-------------------------------------------------------------------------------------EE---------------------HHHHHHHHHHHH-------------------------------------------------------------------------------------------------------------HHHHHHH----------------EEE-----HHHHHHHHHHHHHHHHHH---------------------------------------------HHHHHH----------------------------------------------------------HHHHHHHH--------------EEEEEE--------------HHHHHH-------------------------- RBBP6_2N sspal --EEEEEEE----EEEEEEE-EEEEHHHHHHHHH-----------EEEE--------------------EEEEEEE---EEEEEEEEEEE----------------HHHHHHHHHH---HHHHHHHHHHHHHHHH-----------------------EEEEE--------------------------------EEEEEEEE------------------HHHHHHHHH------------------------HHHHHHHHH-----EEEE---------HHHHHHHHH----------------HHHHH-HHHHHHHHHHH----HHHHHHHHH------------HHHHHHHHHHH---------EEEEEEE------------------------------------EEEEEEEEEE-------------HHHHHHHHH------EEEHHHHHHHHH--EEEEEEE--------------------EEEE---------------EEEEEEE--------------------------------------EEEEE-------------------------------------EEEE--------------------------------------HHHHHHHHHHH----------------EEEE----------EEEEEEE-----------------------------------------------------------------------HHHHHHHHHH-----------------HHHHHHHHHHH--HHHHHHHHHH-------------------------------------------------------------------------------------------HHHHHHHHH---------HHHHH------------------EEEE------------------EEEEEEE---------------------- RBBP6_2N ssp ----------------------------HHHH----------------------------------------------------------------------------------------------HHHHHHH----------------------------------------------------------------------------------------------HH-----------------------------------------------------HHHH---------------------------HHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_2N sspred --EEEEEE--------EE-------HHHHHHHHHHHH-------EEEEEE------------EE----EEEEEEE----------EEEE------------------------------HHH-----HHHHHHHHHHHHHH------------------EE--------------------------EE---------EE---------EEE-----EEEEE--HHHHHHHHHHHHHHHHHH--HHHHH--------------------EEE--------HHHHHHHHHH----E-----------------HHHHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHH------------------------------------------------------------------- RBBP6_2N soprano --EEEEEE-------EEEE----E-HHHHHHHHHHH--------EEEEE-------------E-----EEEEEEE-----------EEE------------------------------HHH----HHHHHHHHHHH----------------------EE-----------------------------------HH-E---------EEE-----EEEE---HHHHHHH-H------------------------------------EE---------HHHHHHHHH-----------------------HHHHHHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH---------------------------------------------------------------------------------------------------------------------------------------------------HHHHH-HHHHHHHHH---------------------------------------------------------------------------------------------------------------HH--------------------EEE------------------------------------------------ RBBP6_2N consensus MNAAASSYPMASLYVGDLHSDVTEAMLYEKFSPAGPVLSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPIRIMWSQRDPSLRKSGVGNVFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYAFVHFETQEAADKAIEKMNGMLLNDRKVFVGRFKSRKEREAELGAKAKEFTNVYIKNFGEEVDDESLKELFSQFGKTLSVKVMRDPNGKSKGFGFVSYEKHEDANKAVEEMNGKEISGKIIFVGRAQKKVERQAELKRKFEQLKQERISRYQGVNLYIKNLDDTIDDEKLRKEFSPFGSITSAKVMLEDGRSKGFGFVCFSSPEEATKAVTEMNGRIVGSKPLYVALAQRKEERKAHLTNQYMQRVAGMRALPANAILNQFQPAAGGYFVPAVPQAQGRPPYYTPNQLAQMRPNPRWQQGGRPQGFQGMPSAIRQSGPRPTLRHLAPTGNAPASRGLPTTTQRVGSECPDRLAMDFGGAGAAQQGLTDSCQSGGVPTAVQNLAPRAAVAAAAPRAVAPYKYASSVRSPHPAIQPLQAPQPAVHVQGQEPLTASMLAAAPPQEQKQMLGERLFPLIQTMHSNLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHHAKKEAAQKVGAVAAATS PABP-4_3 sequence -----------EEEE--------HHHHHHHH-----EEEEEEEE---------EEEEEE--HHHHHHHHHH--------EEEEEEE--------------EEE--------HHHHHHHHH----EEEEEEEE------EEEEEEE--HHHHHHHHHHH-----------EEE----HHHHHHHHH------EEEEE-------HHHHHHHH------EEEEEEE--------EEEEE---HHHHHHHHHHH---EE--EEEEEE----HHHHHHHHHHHHHHHHHHHH-----EEEEE--------HHHHHHH------EEEEEEE-------EEEEEE---HHHHHHHHHHH---EE--EEEEEEEEE--HHHHHHHHHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHH---HHHHHHHHHHHHHHHHHH----------HH-----HHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHH-------- PABP-4_3 psipred -----------EEEE------HHHHHHHHHHH----EEEEEEE----------EEEEE---HHHHHHHHHHH---------EEEEEE-------------EEEE--------HHHHHHHHHH--EEEEEEEE--------EEEE--HHHHHHHHHHHHH--------EEEE-----HHHHHHHHHHHHH---EEEE-------HHHHHHHHHH---EEEEEEEE--------EEEE----HHHHHHHHHHH--------EEEEE----HHHHHHHHHHHHHHHHHHHHHH----EEEEE-------HHHHHHHH-----EEEEEEEE-------EEEEEE--HHHHHHHHHHHHHHH-----EEEEEHHHHHHHHHHHHHHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHH--HHHHHHHH--HHHHHHH---HHHHHHHHHHHHHHHHHHHH---------------- PABP-4_3 prof -----------EEE---------HHHHHHHH-----EEEEEEE------------------HHHHHHHHHHH---------EEEE---------------EEEE----------HHHHHHHH----EEEEEE--------EEEEE-HHHHHHHHHHHH--------EEEE-------------------EEEEEEE------HHHHHHHHH-----EEEEEEEE-----------E----HHHHHHHHHHH--------EEEEE----HHHHHHHHHHHHHHHHHHHH-------EEE--------HHHHHHHH-------EEEEEE-----EEEEEEE----HHHHHHHHHHHHHHHH---EEEE---HHHHHHHHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHH----------------HHHHH------HHHHHHHHHHHHHHHHHH----------------- PABP-4_3 jnet -----------EEEEE-------HHHHHHHHHH---EEEEEEE----------EEEEE---HHHHHHHHHHH--------EEEEEE-------------EEEEE-------HHHHHHHHHH---EEEEEEEE-------EEEEEE--HHHHHHHHHHH--------EEEEEEE------------------EEEEE-------HHHHHHHHHH---EEEEEEE---------EEEEEE--HHHHHHHHHHH--------EEEEEE----------------------------EEEEEE-------HHHHHHHHHH---EEEEEEE---------EEEEE--HHHHHHHHHHH---E----EEEEEEE-------HHHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH----HHHHHHHHHHHHHHHHH------------E-----HHHHHHH--HHHHHHHHHHHHHHHHHHH----------------- PABP-4_3 sable -----------EEEEE-------HHHHHHHHHHHEEEEEEEEEEEE---E---EEEEEE---HHHHHHHHHH--EE---EEEEEEE------E-----EEEEEE-------HHHHHHHHHHHEEEEEEEEE-E------EEEEEE--HHHHHHHHHHH----------EEEEE-----------------EEEEEE-------HHHHHHHHHHH--EEEEEEEEE---EEEEEEEEEE--HHHHHHHHHHH-------EEEEEEE--------HHHH-----------------EEEEE-------HHHHHHHHHHH--EEEEEEEEE------EEEEEEE-HHHHHHHH-----------EEEEEEE--HHH-HHHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH--HHHHHHHHHHHHHHHHHHH---------------HHHHHHHHHH-HHHHHHHHHHHHHHHHHHHH---------------- PABP-4_3 proteus ----------EEEEE--------HHHHHHHHHHH--EEEEEEEE---------EEEEE---HHHHHHHHHHH--EEE--EEEEEEE-------------EEEE--------HHHHHHHHHHH--EEEEEEEE------EEEEEEE--HHHHHHHHHHH--EEE--EEEEEE-----HHHHHHHH-------EEEE--------HHHHHHHHHHH--EEEEEEEE-------EEEEEE---HHHHHHHHHHH--EEE--EEEEEE----HHHHHHHHHHHHHHH-----------EEEE--------HHHHHHHHHH---EEEEEEEE------EEEEEEE--HHHHHHHHHHH--EEE--EEEEEEE---HHHHHHHHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHH--HHHHHHHHHHHHHHHHHHH---------HHHH---HHHHHHHH--HHHHHHHHHHHHHHHHHHHHHH-HHHH--------- PABP-4_3 psspred -----------EEEE--------HHHHHHHHHHH----EEEEEE---------EEEEE---HHHHHHHHHHH-------EEEEEEE-------------EEEE--------HHHHHHHHHHH--E-EEEEEEE------EEEEEE--HHHHHHHHHHHH--EE--EEEEE------HHHHHHHHHHH----EEEE--------HHHHHHHHHHH--E-EEEEEE--------EEEEE---HHHHHHHHHHH--EEE--EEEEEE----HHHHHHHHHHHHHHHHHHHHH----EEEEEE-------HHHHHHHHHHH--E-EEEEE--------EEEEE---HHHHHHHHHHHH-EEE---EEEEEEE--HHHHHHHHHHHHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHH--HHHHHHHHHHHHHHHHHHH-HHHHHHHH-HHHH--HHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHH------- PABP-4_3 spineX ----------EEEEE--------HHHHHHHH-----EEEEEEE----------EEEEEE--HHHHHHHHHH---------EEEEEE-------------EEEE--------HHHHHHHHH----EEEEEEEE-------EEEEEE--HHHHHHHHHHH---EE---EEEEEE------------------EEEEE--------HHHHHHHH-----EEEEEEEE--------EEEEEE--HHHHHHHHHH---EEE--EEEEEE-----------------------------EEEEE--------HHHHHHHE-----EEEEEEEE-------EEEEEE--HHHHHHHHHH---EEE---EEEEEEEE-------------HH---------------------------------------------------------------------------------------------------------------------------------------------HHHH----------------------------------------HHHHHHH-------------EE-----------------------HHHHHHHH--HHHHHHHHHHHHHHHHHHHH---HH-HH-------- PABP-4_3 raptorxss -----------EEEEE-------HHHHHHHHH----EEEEEEEE---------EEEEEE--HHHHHHHHHHH---EE---EEEEEH-------------EEEEE---H---HHHHHHHHHH---EEEEEEEE------EEEEEEE--HHHHHHHHHHH---EE--EEEEEEE-------HHH---------EEEEE-------HHHHHHHHHH---EEEEEEEE------EEEEEEEE--HHHHHHHHHHH---EE--EEEEEE----------H-HHHH--------------EEEEE-------HHHHHHHHH----EEEEEEE--------EEEEEE--HHHHHHHHHHH---EE--EEEEEEEE---HHHHHHH--HHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHH-------HHHHHHHHHHHHHHHH---------HHHH---HHHHHHHH--HHHHHHHHHHHHHHHHHHHH------HH-------- PABP-4_3 SPARROW ------------EEEE-------HHHHHHHHH----EEEEEEEE---------EEEEEE--HHHHHHHHHHH---EE---EEEEEEE-------------EEEE-------HHHHHHHHH----EEEEEEEE-------EEEEE---HHHHHHHHHHH---EE---EEEEEE-------------------EEEEE-------HHHHHHHHHHH--EEEEEEEE-----EE-EEEEE---HHHHHHHHHHH---EE--EEEEEEE------HHHHHHHH---------------EEEEE-------HHHHHHHHH----EEEEEEEE-------EEEEEE--HHHHHHHHHHH---EE--EEEEEEEEE----H-HHH--HHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH---HHH-----HHH----HHH--HHH----HHH-----HHHHHHHH--HHHHHHHHHHHHHHHHHHHH------HH-------- PABP-4_3 *SPARROW ---------EEEEEEEE------HHHHHHHHHHH--EEEEEEEE------EE--EEEEEE-HHHHHHHHHHH--EEE----EEEEEEE--HHHHH---EEEEEE-HHHHH-HHHHHHHHHHHEEEEEEEEEE------EEEEEEEEEHHHHHHHHHHE----E---EEEE-----HHHHHHHHHHHHHHHHHEEEE-------HHHHHHHHHHH-EEEEEEEEE-----EE---EEEEE-HHHHHHHHHHH---EE---EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH---EEEEE---H---HHHHHHHHHHHEEEEEEEEEEH-------EEEEEE-HHHHHHHHHHH---EEEE---HHHHHHHHHHHHHHHHHHHHHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHH--HHHHHHHHHHHHHHHHHHH-HHHH-EEE--EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--HHHHHH------ PABP-4_3 HMMSTR -----------EEEEE-------HHHHHHHHHHH--EEEEEEEE------EEEEEEEEE--HHHHHHHHHHH---EE--EE-EEEE-----HHHH----EEEEE-------HHHHHHHHH----EEEEEE----------EEEEE--HHHHHHHHHH----EE--EEEEEEE-------------------EEEEE-------HHHHHHHHHH---EEEEEEEE-----EEEEEEEEE--HHHHHHHHHHH---EE--EEEEEEE-----------------------------EEEEE-------HHHHHHHHH----EEEEEEEE-----EEEEEEEE--HHHHHHHHHHH---E----EEEEEE------------HHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHH------H-HHHHHHHHHHHHHHH-HHHHHHHHHHH----HHHHHHHHH-HHHHHHHHHHHHHHHHHH------------------ PABP-4_3 porter -----------EEEE--------HHHHHHHH------EEEEEEE---------EEEEEE--HHHHHHHHHHH---------EEEE--------------EEEE--------HHHHHHHHH-----EEEEEEE-------EEEEEE--HHHHHHHHHHH---------EEEEE------------------EEEEE--------HHHHHHHH-----EEEEEEEE--------EEEEEE--HHHHHHHHHHH---------EEEEE-------HHHHHHHH-------------EEEEEE-------HHHHHHHH-----EEEEEEEE-------EEEEEE--HHHHHHHHHHH---------EEEEE------HHHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHH---------------HHHHHHHHH-HHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHH-------- PABP-4_3 cdm -----------EEEEE-------HHHHHHHHHHH--EEEEEEEE------EEEEEEEEE--HHHHHHHHHH----EE--EE-EEEE-------------EEEEE-------HHHHHHHH-----EEEEEEE--------EEEEEE--HHHHHHHHHHH---EE--EE-EEEE------------------EEEEE--------HHHHHHHH-----EEEEEEEE--------EEEEEE--HHHHHHHHHHH---------EEEEE-------HHHHHHHH--------------EEEEE-------HHHHHHHH-----EEEEEEEE----EEEEEEEEE--HHHHHHHHHHH----------EEEE---------HHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHH--HHHHHHHHHHHHHHHHHHH----HHHHHHHH----HHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHH-------- PABP-4_3 fdm -----------EEEEE-------HHHHHHHHHHH--EEEEEEEE------EEEEEEEEE--HHHHHHHHHH----EE--EE-EEEE-------------EEEEE-------HHHHHHHH-----EEEEEEE--------EEEEEE--HHHHHHHHHHH---EE--EE-EEEE-------------------EEEEE-------HHHHHHHHH----EEEEEEEE--------EEEEEE--HHHHHHHHHHH---EE--EE-EEEE-----------------------------EEEEE-------HHHHHHHH-----EEEEEEEE----EEEEEEEEE--HHHHHHHHHHH----------EEEE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHH--HHHHHHHHHHHHHHHHHHH----HHHHHHHH----HHHHHHHHH-HHHHHHHHHHHHHHH--------------------- PABP-4_3 gor -----------EEEEE-------HHHHHHHHH----EEEEEEEE---------EEEEEE--HHHHHHHHHHH---EE---EEEEE--------------EEEEE-------HHHHHHHHHH---EEEEEEEEE-----EEEEEEE--HHHHHHHHHHH--EEE---EEEE-------HHHHHHHHHHH---EEEEE-------HHHHHHHHHHH--EEEEEEEE-------EEEEEEE--HHHHHHHHHHH--EEE---EEEEE------HHHHHHHHHHHHHHHHH-------EEEEE-------HHHHHHHH-----EEEEEEEE------EEEEEEE--HHHHHHHHHHH--EEE--EEEEEEE----HHHHHHHHHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH---HHHHHHHHHHHHHHHHHHH-HHHH---EEEE----HHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--- PABP-4_3 spine HHHHH------EEEE------HHHHHHHHH------EEEEHHHHHHHHH-----EEE-----HHHHHHHHHH---EE----EEEEE--------------EEE---------HHHHHHHHH------EEEEE-------EEEEEE--HHHHHHHHHHHHHHH-----EEEE-----HHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHH-----EEEE-----------EEEE--HHHHHHHHHHHH------EEEEEE--HHHHHHHHHHHHHHHHHHHHHHHH-----EEE---------HHHHHHH-------HHHHHHHH------EEEEE--HHHHHHHHHHH---------HHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHH-------EE---------------HHHHH-----------------------------------------------------------------------HHHHHHHHHH-------------HHHHHHHH--------------------------------------HHHHHH----HHHHHHHHHHHHHHHHHHHH--------EEEE---HHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH- PABP-4_3 nnssp -----------EEEEE-------HHHHHHHHHHH--EEEEEEEE------EEEEEEEEE--HHHHHHHH-------------EEEE-----HHHH----EEEEE-------HHHHHHHHHHH--EEEEEE----------EEEEE--HHHHHHH-----EEEE--EEEEEEE---HHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHH--EEEEEEEE-----EEEEEEEEE--HHHHHHHHHHH--------EEEE-HHHHHHHHHHHHHHHHHHHHHHHHHHH---EEEEE-------HHHHHHHH-----EEEEEEEE----EEEEEEEEE--HHHHHHHHHHH---------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----------------------HHHHHHH-------------------------------------------------------------------------------------HHHHHHHHHHHHHHH----------------------------------------HHHHH---HHH---------HHHHHHH----HHHHHHHHHH--HHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-- PABP-4_3 pssfinder HHHHHH----EEEEE------HHHHHHHHH------EEEHHHHHHHH--------EEE------HHHHHHHHHHEEE-----EEEEE-------------EEE--------HHHHHHHHHH---EE--EEE----------EEE--HHHHHHHHHHHHH--------EEEE-----HHHHHHHHHHHHH---HHHHHH-----HHHHHHHHHHH-----EEEEE-----------EEE--HHHHHHHHHHHH------EEEEE---HHHHHHHHHHHHHHHHHHHHH------EEEEHHHH-----HHHHHHHH----EE-HHHHHHHH------EEEEE--HHHHHHHHHHH--------HHHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHH-----------------------HHHHHH---------------------HHHH-------EEE-------------------------HHHH------HHHH------------HHHHHH-HHHHHHHH-HHH--------------------------EEE-------HHHHH---HHHHHHHHHHHHHHHHHHHHHHH------HHH-----HHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH- PABP-4_3 sspal ------------EEEE--HHHHHHHHH---------EEEEEEEHHHHHHHHH-------HHHHHHHHHHH-----------EEEE---------------EEEEHHHHHHHHHHHHHHHHHH--EEEEEEEE--------HHHHHHHHHHHHHHHHHH--------EEEEHHHHHHHHHHHHH------EEEEEEE---HHHHHHHHHHHHHH---EEEEEEE------------HHHHHHHHHHHHHHHH--------EEEEHHHHHHHHHHHHHHHHHHHHHHHH---------------HHHHHHHHHHHH--------------------EEEEEEE--HHHHHHHHHH--EEEE---HHHHHHHHHHHHHH---HHHHHHHHHHHHH-HHHHHHHHH-----EEEE---------------HHHHHH-------------------------------------------------------------------------------------HHHHHHHHHHHHHHH-----------------------------EEEE--HHHHHHHHHHH--HHHHHHHHHHH--HHHHHHHHHH--EEEEEEEE--HHHHHHHHH-HHHHHHHHHHHHHHHH--HHHHHHHHH-------- PABP-4_3 ssp -----------EEEEE-------HHHHHHHHHH---EEEEEEE----------EEEEEE--HHHHHHHHHHH---------EEEE--------------EEEEE------HHHHHHHHHHHH--EEEEEEE-------EEEEEEE--HHHHHHHHHHHH-------EEEEEE--------------------EEEE-------HHHHHHHHHH----EEEEEEE--------EEEEEE--HHHHHHHHHHH---------EEEE------------------------------EEEEE-------HHHHHHHHHH-----EEEEE-------EEEEEEE--HHHHHHHHHHH---------EEEEE------------HHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHH------HHHHH-------HHHH-----HHHHHHHH--HHHHHHHHHHHHHHHHHHHH---HH-HHH------- PABP-4_3 sspred -----------EEEEE-------HHHHHHHHHH---EEEEEEEE---------EEEEE---HHHHHHHHHHH--------EEEEEE-------------EEEE--------HHHHHHHHHH---EEEEEEEE-------EEEEEE--HHHHHHHHHHH---EE---EEEEEE-------------------EEEEE-------HHHHHHHHHH---EEEEEEEE-------EEEEEE---HHHHHHHHHHH---EE---EEEEE---------HHHHHH---------------EEEE--------HHHHHHHHHH---EEEEEEEE------EEEEEEE--HHHHHHHHHHH---EE--EEEEEEE-----HHH-H-HHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHH-----HHHHHHHHHHHHHHH-------------------HHHHHHH---HHHHHHHHHHHHHHHHHHHH---------------- PABP-4_3 netsurfp -----------EEEE--------HHHHHHHHH----EEEEEEE-----------EEEE---HHHHHHHHHHH---E----EEEEE--------------EEEE--------HHHHHHHHHH----EEEEEEE--------EEEEE--HHHHHHHHHHH---EE---EEEE-E-E-----------------EEEE--------HHHHHHHHH----EEEEEEEE--------EEEEEE--HHHHHHHHHHH---EE---EEEE---------HHHHHHHHHH------------EEEE--------HHHHHHHHH----EEEEEEE---------EEEEE--HHHHHHHHHHH---EE---EEEEEE--------HH--HHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH----HHHHHHHHHHHHHHHHHH-HHH------EH----HHHHHHHH--HHHHHHHHHHHHHHHHHHHH-H--HHH--------- PABP-4_3 soprano -----------EEEEE-------HHHHHHHHH----EEEEEEEE---------EEEEEE--HHHHHHHHHHH---E----EEEEEE-------------EEEEE-------HHHHHHHHHH---EEEEEEEE-------EEEEEE--HHHHHHHHHHH---EE---EEEEEE-------------------EEEEE-------HHHHHHHHHH---EEEEEEEE--------EEEEEE--HHHHHHHHHHH---EE---EEEEE-------HHHHHHHHHHH------------EEEEE-------HHHHHHHH-----EEEEEEEE-------EEEEEE--HHHHHHHHHHH---EE---EEEEEE----HHHHHHHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH---HHHHHHHHHHHHHHHHHHH---------HHH----HHHHHHHH--HHHHHHHHHHHHHHHHHHHH-H-HHHHH-------- PABP-4_3 consensus MAAVDSDVESLPRGGFRCCLCHVTTANRPSLDAHLGGRKHRHLVELRAARKAQGLRSVFVSGFPRDVDSAQLSEYFLAFGPVASVVMDKDKGVFAIVEMGDVGAREAVLSQSQHSLGGHRLRVRPREQKEFQSPASKSPKGAAPDSHQLAKALAEAADVGAQMIKLVGLRELSEAERQLRSLVVALMQEVFTEFFPGCVVHPFGSSINSFDVHGCDLDLFLDLGDLEEPQPVPKAPESPSLDSALASPLDPQALACTPASPPDSQPPASPQDSEALDFETPSSSLAPQTPDSALASETLASPQSLPPASPLLEDREEGDLGKASELAETPKEEKAEGAAMLELVGSILRGCVPGVYRVQTVPSARRPVVKFCHRPSGLHGDVSLSNRLALHNSRFLSLCSELDGRVRPLVYTLRCWAQGRGLSGSGPLLSNYALTLLVIYFLQTRDPPVLPTVSQLTQKAGEGEQVEVDGWDCSFPRDASRLEPSINVEPLSSLLAQFFSCVSCWDLRGSLLSLREGQALPVAGGLPSNLWEGLRLGPLNLQDPFDLSHNVAANVTSRVAGRLQNCCRAAANYCRSLQYQRRSSRGRDWGLLPLLQPSSPSSLLSATPIPLPLAPFTQLTAALVQVFREALGCHIEQATKRTRSEGGGTGESSQGGTSKRLKVDGQKNCCEEGKEEQQGCAGDGGEDRVEEMVIEVGEMVQDWAMQSPGQPGDLPLTTGKHGAPGEEGQPSHAALAERGPKGHEAAQEWSQGEAGKGASLPSSASWRCALWHRVWQGRRRARRRLQQQTKEGAGGGAGTRAGWLATEAQVTQELKGLSGGEERPETEPLLSFVASVSPADRMLTVTPLQDPQGLFPDLHHFLQVFLPQAIRHLK TUT1_1 sequence ---------------EEEEEEEEEE--HHHHHHHH------HHHHHHHHHHHH---EEEEE-------HHHHHHHHHH-----EEEE-----EEEEEEE--HHHHHHHHH---------EEE-----------------------HHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHH----EEE-----------------------------------------------------------------------------------------HHHHHH--------------------------EE------HHHHHHHHHHHHHHHHHHH------EEEEEE-----EEEEEEE----EEEEEEEE--HHHHHHHHHHHHHH----HHHHHHHHHHHHHH-----------HHHHHHHHHHHHH---------HHHHH--------EEE----------------------HHHHHHHHHHHH---------EEE------------------------EEEE--------------HHHHHHHHHHHHHHHHHHHHHH-------------------------------------HHHHHHHHHHHHHHHH---------------------------------------------------------HHHHHHHH----------------------------------------------------------------------------HHHHHHHHHHHHHHHHHH------------HHHHHHHHHHHHH--------------EEEEE------EEEEEEE--------HHHHHHHHHHHHHHHHH-- TUT1_1 psipred -------HHH-----EEEEEEEEE-----HHHHHH-------HHHHHHHHHHH---EEEEEE------HHHHHHHHHH---EEEEEEE----EEEEEEE---HHHHHHHH---------EEEEE---------------------HHHHHHHHHH---HHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH----EE-------------------EE------------------------------------------------------------HHHHHHHHHHHHHHHH--------------------------EE----------HHHHHHHHHHHHHHHH-----EEEEE------EEEEE------EEEE----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------HHHHHHHHHHHHHHH---------HHH----------EEE----EEE---HHH-------HHHHHHHHHHHHHHHH------EEEEE-----------------------EEEE--------------HHHHHHHHHHHHHHHHHHHH-------------------------------------------------------------------------------------------------------------HHHHHHH---------------------------------------------------------------------------------------HHHHHH------------------------EEEEE--------------EEEEEEE-----EEEEEE---------HHHHHHHHHHHHHHHHH-- TUT1_1 prof -HHHHH---E-----EEEEEEEEE----HHHHHHHH------HHHHHHHHHH---EEEEE--------HHHHHHHHH----EEEEEEE----EEEEEE-----HHHHHHH------------------------------------HHHHHHH-----HHHHHHHHHH--------HHHHHHHHHHHHHHHHHH----EEE---------------EEEEEE---------------------------------------HHHHHHHHH---------HHHHHHHHHHHHHHHHH------------------------EEEEEEE--------HHHHHHHHHHHHHHH--------EE-----EEEEEEE-----EEEEEE---HHHHHHHHHHHHHH------HHHHHHHHHHHHHH----------HHHHHHHHHHHH-----------------------EEEE---E-----------------HHHHHHHHHHHHHHH-----EEEE-----------------------EEEEE--------------HHHHHHHHHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEE-----------------------HHHHHH---------------EEEEEE-----EEEEEE--------HHHHHHHHHHHHHHHHHH-- TUT1_1 jnet --E------------EEEEEEEEEE----HHHHHH--------HHHHHHHHH---EEEEEE-------HHHHHHHHHH----EEEEE------EEEEEE---HHHHHHHH------------------------------------HHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHH----EEEE-----------------------------------------------------------------------HH----------------HHHHHHH-----------------------EEEEE---------HHHHHHHHHHHHHHHH----EEEEEE----EEEEEEEE----EEEEEEE----HHHHHHHHHHHHHH--HHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHH---------HH----------EE----EE----------------HHHHHHHHHHHHHHH-------EEE------------------------EEE---------------HHHHHHHHHHHHHHHHHHHHH---------------------------------------HHHHHHHHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHH----------------HHHHHHHH--------------EEEEE------EEEEEE--------HHHHHHHHHHHHHHHHHHHH TUT1_1 sable -----------------EEEEEEEE--HHHHHHHHH-------------HHH---EEEEEE-EEE---HHHHHHHHH--EEEEEEEEE----EEEEEEEE-HHHHHHHHH----------EEEE------------------HHHHHHH-----------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------------------------HHHHHHHHHHHHH---HHH-----------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------------------EEEEEEE--------HHHHHHHHHHHHHHHHH---EEEEEEE-----EEEEEEE----EEEEEEEE---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------HHHHHHHHHHHHHH----------------------EEE---EE-----------------HHHHHHHHHHHHHH-----EEEEE------E----------------EEEEE--------------HHHHHHHHHHHHHHHHHHHHHH--------------------------------------HHHHHHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------EEE--HHHHHHHHHHHHHHHHHHH---------------HHHHHHHHHHH-------------EEEEEE------EEEEEEE--------HHHHHHHHHHHHHHHHH-- TUT1_1 proteus --------E-------EEEEEEEEE--HHHHHHHHH--------HHHHHHHHHH--EEEEE-------HHHHHHHHHHH--EEEEEEE-----EEEEEE---HHHHHHHH------------------------------------HHHHHHHHH----HHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHH----EEEE--------------HHHHH-----------------------------HHHHH--------------HHHHHHHHHHHHHHHHHHHHHHHHHHHH----------------------EEEEEEE--------HHHHHHHHHHHHHHHHH---EEEEEEEE---EEEEEEEE-----EEEEEE---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHH--------HHHHHH-------EEE--EEE-----HHH---------HHHHHHHHHHHHHHH-----EEEEE---EEE-----------------EEEE--------------HHHHHHHHHHHHHHHHHHHHH-------------HHHH------HHHH--------------HHHHHHHHHHHH-----------------------------------------------------------------------HHHH------------------------------------------------------------EEEEEEE-HHH-HHHHHHHHHHHHHH------------HHHHHHHHHHHH--------------EEEEE------EEEEEEE--------HHHHHHHHHHHHHHHHH-- TUT1_1 psspred -HHHH----------EEEEEEEEE---HHHHHHHHH------HHHHHHHHHHH---EEEEE-------HHHHHHHHHHH----EEEEE----EEEEEEE--HHHHHHHHHH-------------HHHH-----------------HHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH---EEEEE---------------EEEEEE-------------------H-------HHHHH------------------------------------HHHHHH-HH---------------------EEE------HHHHHHHHHHHHHHHHHHHHH---EEEEEE-------EEEEEE----EEEEEEE--HHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHH--------HHHHHHH------EEE--EEE-----------------HHHHHHHHHHHHHH------EEEEE---EE------------------EEEE--------------HHHHHHHHHHHHHHHHHHHHHHHH-----------------------------------HHHHHHHHHHHHHHHHHH----HH-----------------------E-----E-E------------------H-E----------HHH---------------------------HHH-----------H-------------------HEEEEEHHHHHHHHHHHHHHHHHHH---------HHHHHHHHHHHHHHHHH-----------HHHHHHH------EEEEE---------HHHHHHHHHHHHHHHHHH- TUT1_1 spineX -------EEE-----EEEEEEEEE---------------------HHHHHHH---EEEEE--------HHHHHHHHHH------EE------EEEEEEE---------------------E-----------------------------H---------HHHHHHEEE----HHHHHHHHHHHHHHHHHHH------EEEE---------EEEE-EEEEEE---EEE----------------------------------------------------------------EEEE-----EEEE----------------EEEEE--------HHHHHHHHHHHHHHH------EEEEE-------EEEEEE-----EEE-----HHHHHHHHHHHHHHHH----HHHHHHHHHHHH------------HHHHHHHHHHHHH----------------------EEE---EEEE---------------HHHHHHHHHHHHEEE-----EEEEE----EE----------------EEEEE--------------HHHHHHHHHHHHHHHHHH---------------EEE-----------E-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEE------------------------------EEE----------HHHHHHHHH--HHHHH--- TUT1_1 raptorxss -HHHHHHHHE-----EEEEEEEEEE--HHHHHHHH-------HHHHHHHHHHHHH--EEEE-------HHHHHHHHHHH--EEEEEEE-----EEEEEE--HH-HHHHHHHHHHHH--------HH-------------------HHHHHHHHHH---HHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHH----EEEEE---------------EHHHH-----------HHHHHHHHHHH---HHHHHH---------------HHHHHHHHH---HHHH------HHHHHH-----------------------EEEEEE--------HHHHHHHHHHHHHHHH-----EEEEEE----E-EEEEEE----EEEEEEE--HHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHH-----------HHHHHHHHHHHH----------HHH----------EEE--EEE-----HHH---------HHHHHHHHHHHHHHH-----EEE----------H--------------EEEE--------------HHHHHHHHHHHHHHHHHHHHHHH------------HHH------HHHH--------------HHHHHHHHHHHHHH--------------------H------HHHHHHHH------HH-H-------------HHHH--------HHHH------------------------------H-----HHHHHH----H-----------HHHHHHH-HHH--HHHHHHHHHHHHHH-----------HHHH-HHHHHHHHH----H-------HHHHHE------EEEEEEEE-------HHHHHHHHHHHHHHHHH-- TUT1_1 SPARROW -------EEE------EEEEEEEEE--HHHHHHHH-------HHHHHHHHHHHH--EEEEE-------HHHHHHHHHH-----EEEEE-----EEEEEE-------------------------------------------------------------HHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH----EEEE-------------------HHH-H-----------------HHHHHH-------------------HHHHHHHHHHHHHHHHHHHHHHHHHH--------------------------EEEEE--------HHHHHHHHHHHHHHHHH-------EEE----EE-EEEEEE----EEEEEE----HHHHHHHHHHHHHHH--HHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHH--------HHHH---------EEE---EEE-----HH---------HHHHHHHHHHHHHH------EEEE----EE---HHHH-----------EE-------HH--H----HHHHHHHHHHHHHHHHHHH----------------HHH----------------------------H----------------------------------------------------------------------H--------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHH-------------HHHHHHHHH---------------------------EEEE----------HHHHHHHHHHHHHHHHH-- TUT1_1 *SPARROW HHHHHHHHHH--------HH-HEEEE-HHHHHHHH----HHHHHHHHHHHHHHHHHEEEEEE------HHHHHHHHHHH-EEEEEEE------EEEEEEE-HHHHHHHHHH--------EEEEE---------------------HHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH----EEE---------------HHHHEEHHH--------------------------------HHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHH-------EE----------------EEEEE-------H--HHHHHHHHHHHHHHH-----EEEEEE------EEEEE-----EEEEEEE-EEEEEHHHHHHHHHHH---HHHHHHHHHHHHHHHEE-----EEEEEEEEEEEEEEHHH--------HHHHHHHHH---EEEEE---EEEE--HHHE-----HHHHHHHHHHHHHHEEEE----EEEEE-----E-----------------EEEEE--------------HHHHHHHHHHHHHHHHHH--------------H-HHHH-------HH------------HHHHHHHHHHHHHHH--------------------------HHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHH---------------------------------------------------------------------HHHHHHHHHHHHHH-----------HHHHHHHHHHHHHHHHH---------HHHHHEEEEHHHHHH-EEEEE----HHHHHHHHHHHHHHHHHHHHHHHH TUT1_1 HMMSTR ----------------EEEE--E---------H-------HHHHHHHHHHHH----EEEEE-------HHHHHHHHHH---EEEEEE------EEEEEE--HHHHHHHH-----EE--EE---E----------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----EE-----------------HHHEE------------------HHHHH-----HHH--------------------------------------HHH--------------------------EEEE---------HHHHHHHHHHHHHHHHH-----EEEEEE---E--EEEEEE------EEEEE---HHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHH---E-----E-HHHHHHHHHHHHHH---------------------EEE--------------------HHHHHHHHHHHHHHH-------EEEE----EE------------------EEEE-------HH-----HHHHHHHHHHHHHHHHHHHHH--------------EEE-------HH-------------HHHHHHHHHHHHHHH----H------------------------E---------------------------HHHHEEEE----HHHHH--------------------------HHHHHH----------------------------HHHHHHHHHHHHHHHHHHHHHHHH------------HHHHHHHHHHHH-----------------EEE-----HH-----------------HHHHHHHHHHHHHHH-- TUT1_1 porter -----EEEEE----------EEEEE---HHHHHHHHHH-------HHHHHHH----EEEEE-------HHHHHHHH------EEEEEEE-----EEEEE---HHHHHHHHH---------HHHHHHHHHHHHHHHHHHHHHH----HHHHH-------HHHHHHH--------HHHHH----------------------------------------------------------------------------------------------------HHHHHHHHH---------------------------------EEEE---------HHHHHHHHHHHHHHHHH-------HHHH------EEEE-------EEEEE------HHHHHHHHHHH-------HHHHHHHHHHHH-------------HHHHHHHHHHH---------------------------------------------HHHHHHHHHHHHH---------EEEE-----------------------EEEE-----------------HHHHHHHHHHHHHHHHHH------------------------------------------HHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHH--------HHHHHHHHHHHHHH-----------------EEEE--------------------------HHHHH--------- TUT1_1 cdm -----EEEEE----------EEEEE---HHHHHHHHHH-------HHHHHHH----EEEEE-------HHHHHHHHHH---EEEEEE------EEEEEE--HHHHHHHH-----EE--EE--------------------------HHHHH-------HHHHHHH--------HHHHH----------------------------------------------------------------------------------------------------HHHHHHHHH---------------------------------EEEE---------HHHHHHHHHHHHHHHHH-------HHHH------EEEE-------EEEEE------HHHHHHHHHHH-------HHHHHHHHHHHH-------------HHHHHHHHHHH---------------------------------------------HHHHHHHHHHHHH---------EEEE-----------------------EEEE-----------------HHHHHHHHHHHHHHHHHH------------------------------------------HHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHH--------HHHHHHHHHHHHHH-----------------EEEE--------------------------HHHHH--------- TUT1_1 fdm ------------------HHH-EEE--HHHHHHHH-----EEE--HHH--------EEEEE-------HHHHHHHHHH---EEEEEE------EEEEEE--HHHHHHHH-----EE--EE--------------------------HHHHHHHHH-HHHHHHHHH--------EEEEEEHHHHHHHHHHHH-------EEEEEHHH-------------------------------------------------------------------------------------------------------------------HHH-----------EEEEEEE----EEEE-----EEE-EE------EEEEE-----EEEEEE-----HHHHHHHHHHHH---HHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHH----------------------------EE---HH---------------HHHHHH-EEE------------------------HHH-------------HH---EEEEEEE-----EEEEE----EEEEEEEE--HHHH---EEE-----------------------------------------------------------------------------------------------------------------HHHH-------------HH----HHHHHHHHHHHHH-HHHH-----EEEE---------------HHHH--------------------------------------------------------------------------------------HHHHHHH---HHHHHH- TUT1_1 gor --EEEE----------EEEEEEEE---HHHHHHHHH-------HHHHHHHHH----EEEEE-------HHHHHHHHHH---EEEEEEE----EEEEEEE---HHHHHHHH---E-E---EEEE-----HHH-------------HHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHH---EEEEE---EE--HHH-----EEEE------------------------------HHH------------------HHH------------------HHHHH-----------HHHHHH-----EEEEEE----HHHHHHHHHHHHHHHHHHHH----EEEEEE-------EEEEEE----EEEEEEE--HHHHHHHHHHHHHHH-----HHHHHHHHHHHHH-----------HHHHHHHHHHHHH---------HHHHHHH-------EE---------------------HHHHHHHHHHHHEEEE-----EEEE----EEE-------HHHH------E-----------------HHHHHHHHHHHHHHHHHHHHHH------------EEEE---------------------HHHHHHHHHHHHHHHHH--HHHHHHH------------------EEEE------E------------------EEEEEEEE---HHHHH---------------------------HHHHHH------HHHHH----------------HHHHHHHHHHHHHHHHHHHHHHHHHH------------HHHHHHHHHHHHH------------HHHHHHH------EEEEEE---------HHHHHHHHHHHHHHHHH-- TUT1_1 spine -----------------EEEEE------------------HHHHHHHHHHHH----EEEE--------HHHHHHHHHH-----EEEE-----EEEEEE------HHHHHH----------EEE----------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------------------------------------------------------------------------------------------------HHHHHH-----------------------HHHHHHH--HHHHHHHHHHHHHHHHHH--------------------EEE------------------------HHHHH--------EEEEHHHHH-------------HHHHHHHHHHHH----------HHHHHHH-----EEEE----------------------HHHHHHHHH---------------------------------------------------HHHHH-HHHHHHHHHHHHHHHHHHHHHHHHH-----------------------------------HHHHHHHHHHHHHHH---HHHHHHHH------------------EE------------------------HHHHHHHHHHHHHHHHHH---------------------------HHHHHH-----HHHHHHHH----------------HHHHHHHHHH-HHHHHHHHHHHHH------------HHHHHHHHHHHHHH--------------------------EEE------------HHHHHHHHHHHHHHHHH TUT1_1 nnssp ---------------------------------------HHHHHHHHHHHHH----EEEEE-------HHHHHHHHHHH--EEEEEEE----EEEEEEE----HHHHHHHHHHHH----EEEEEE--------------------HHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHH---EEEE---------------HHHHHHH-----------------HHHHHH----HHHHH------------------------------------HHHHHHHH--------------------HHHHHHHHH--HHHHHHHHHHHHHHHHHH------EEEEEE-------EEEEEE----------HHHHHHHHHHHHHHHHHHH------EEEEEEEEEE--------HHHHHHHHHHHHHHHHH---------HHHHHHHH----EEEE----------------------HHHHHHHH-----HHHHHHHHHHHHH-----------HHHHHHHHH-------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHH-----------------EEEEEE------------------------HHHHHHHHHHHHHHHHHHH-------------------------HHHHHHH---HHHHHHHHHH------------HHHHHHHHHHHHHHHHHHHHHHHH-------------HHHHHHHHHHHHHHHHH-----------EEEEEEEE----EEEEEEE----------HHHHHHHHHHHHHHH-- TUT1_1 pssfinder EEEE-------------EEEEE---------HHHH-------HHHHHHHHHH----EEEEE-------HHHHHHHHHH-------EE-----EEEEEEE-----HHHHHHH-------EEEEEEE--------------------HHHHHHHHHHHH--HHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHH--EEEE-----EE-----------EEE-----------------------------------------------------------------------HHH--------------HHHHH----------------HHHHH-HHHHHHHHHHHH------EEEEE--------EEEEE--------------EEE-----HHHHH---------EEEEEEEE--------------------HHHHH-----------HHHHHH------EEEE----------------------HHHHHHHH--EEEE--------------------------------------------HHHHHHHHHHHHHHHHHHHH---HHHHHHHHHH------------------------------------HHHHHHHHHHHHHH---HHHHHHHH----------------EEEEE-----------------------HHHHHHHHHHHHHHHHH---------------------------------------HHHHHHHH-----------------HHHHHHHH-HHHHHHHHHHHHHH-----------HHHH-HHHHHHHH-----------------EEE-------------------------HHHHHH-HHHHHHHH TUT1_1 sspal ---------------EEEEEEEEE------HHHHH-----HHHHHHHHHHHH--EEEEEEE-----HHHHHHHHHHHH---EEEEE------EEEEEEE--HHHHHHHHH--------------------------------HHHHHHHHHHHHHHH-HHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHH-EEEE--------------HHHHHHHHH--------------HHHHHHHHH--------------------------------------------------------------HHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHH----------EEEEEEEE-----EEEE------------HHHHHHHHH-HHHHHHHHH---EEEEEEEEEE----------------EEEEEEEEEEE---------HHHHHHHHH----EEEE--------------------HHHHHHHHHHHH----HHHHHHHHHHHH----------------------------------HHHHHHHHHHHHHH------------------------------------------------HHHHHHHHHHHHHHHHHH------------------------------EEEE---------------------HHHHHHHHHHHHHHHHH--------------------------HHHHHHHHHH----HHHHHHHHH------------HHHHHHHHHHHHH-HHHHHHHHHH------------HHHHHHHHHHHHHHHH-------------EEEEEEEEE-----EEEE-------HHHHHHHHHHHHH-------- TUT1_1 ssp ------EEEE-----------EEEE--HHHHHHHHH-------------------EEE----------HHHHHHHHHH---EE-EEEE----EEEEEEE--HHHHHHHHH------------EE--------------------HHHHHHHHHH------HHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH-------------------------EE-------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHH-------------------EEEE-----EEEEEE------HHHHHHHHHHHH---HH-HHHHHHHHHHH-----------HHHHHHHHHHHHHH--------HH------------------------------------HHHHHHHHHHHHEEE----EEEE-------------------------EEEE--------------HHHHHHHHHHHHHHHHHHHHHH------------HH--------------------------HHHHHHHHHHHHH---HH-HH-------------------------------------------------HHHH-HHHH----------------------------------HHHHH------------------------------HH-HHHHHH-----HHHHHHHH-----------------HHHHHHH-----------------HEEH--------EEE--------------HHHHHHHHHH-HH--- TUT1_1 sspred ---------------EEEEEEEEEE--HHHHHHHH-------HHHHHHHHHHH--EEEEEE-------HHHHHHHHHH---EEEEEEE----EEEEEEE--HHHHHHHHH----------EEE----------------------HHHHHHHHHHH-HHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHH------E-------------------H-------------------------------HHHHHHHHH--------HHHHHHHHHHHHHHHHHHHHHHHHHHHHH----------------------EEEEEE--------HHHHHHHHHHHHHHHHH--------EE-----E-EEEEEE----EEEEEEE----HHHHHHHHHHHHHH--HHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHH--------HHHHHH--------E-----------------------HHHHHHHHHHHHH-------EEEE-----------------------EEEEE--------------HHHHHHHHHHHHHHHHHHHHHH---------------------------------------HHHHHHHHHHHHHH------------------------------HH--------------------------HH---H-----HHH-----------------------------------------------------------------------------HHHHHHHH-------------------HHH-HHH---------------------------EEEEE---------HHHHHHHHHHHHHHHHH-- TUT1_1 netsurfp ---------------EEEEEE-EEE---H-HHHHH-------HHHHHHHHHHHH---EEE--------HHHHHHHHHH----EEEEEE-----EEEEEE--HHHHHHHHHH----------------------------------HHHHHHHHHHH--HHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHH----EEEE--------------EEEEEEE--------------HHHHHHH-------HHH-----------------HH------------------------------------------------EEEE--------HHHHHHHHHHHHHHHHHH----EEEEEE------EEEEEE----EEEEEEE----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHH--------HHHHHH-------EEE----EEE---------------HHHHHHHHHHHHHHHHH---EEEE----EEEE---------------EEEEE--------HH----HHHHHHHHHHHHHHHHHHHHHH------------HHHHH-----HHH------------HHHHHHHHHHHHHHHHHH----------------------------E------EEE---------------------EE-----------------------------------------------------------------------EEEEEEE-EH----HH--EHHHH-HH------------HHHHHHHHHHHHHH------------EEEEE------EEEEEE----------HHHHHHHHHHHHHHHHH- TUT1_1 soprano ----------------EEEEEEEEE---HHHHHHH-------HHHHHHHHHH----EEEEE-------HHHHHHHHHH---EEEEEEE----EEEEEEE--HHHHHHHHH-----------------------------------HHHHHHHHHHH--HHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH----EEE-------------------E----------------------------------------------------------------------HHHHH-------------------------EEEE--------HHHHHHHHHHHHHHHHH-----EEEEEE------EEEEEE-----EEEEEE---HHHHHHHHHHHHHHH---HHHHHHHHHHHHHH-----------HHHHHHHHHHHHH---------HHHH---------EEE----E-----------------HHHHHHHHHHHHHH------EEEE------------------------EEEE--------------HHHHHHHHHHHHHHHHHHHHH----------------------------------------HHHHHHHHHHHHHH----------------------------------------------------------HH----------------------------------------------------------------------------------HH--HHHHHHHHHHHHH------------HHHHHHHHHHHHH--------------EEEEE-------EEEEE---------HHHHHHHHHHHHHHHHH-- TUT1_1 consensus MGEEANDDKKPTTKFELERETELRFEVEASQSVQLELLTGMAEIFGTELTRNKKFTFDAGAKVAVFTWHGCSVQLSGRTEVAYVSKDTPMLLYLNTHTALEQMRRQAEKEEERGPRVMVVGPTDVGKSTVCRLLLNYAITSRLADVFNQRCEVNRRASVSGCVINTCGWVKGSGYQALVHAASAFEVDVVVVLDQERLYNELKRDLPHFVRTVLLPKSGGVVERSKDFRRECRDERIREYFYGFRGCFYPHAFNVKFSDVKIYKVGAPTIPDSCLPLGMSQEDNQLKLVPVTPGRDMVHHLLSVSTAEGTEENLSETSVAGFIVVTSVDLEHQVFTVLSPAPRPLPKNFLLIMDIRFMDLK CLP1_2 sequence ------------EEEEE----EEEEEEE---EEEEEEEEEEEEEE--------EEEE----EEEEEEEE--EEEEEE---EEEEE----HHHHHHHHHHHHHHHHHHHH------EEEEE------HHHHHHHHHHHHHHHHHHHHHHHHH----------EEEE---------HHHHHHHHHH----EEEEE---HHHHHHHHH----EEEEEE-----EEE--HHHHHHHHHHHHHHH------EEEEEEEEEE---EEEEEE---------------------EEEE----------EEEEE-----HHHHHH---EEEEEEEEEE----EEEEE----------EEEEEEE-EEE-- CLP1_2 psipred -------------EEEE----EEEEEE----EEEEEEE--EEEEE-EEE----EEEE----EEEEEEE---EEEEE---EEEEE-----HHHHHHHHHHHHHHHHHHHH------EEEEE------HHHHHHHHHHHHHHHHHHHHHHHHH----------EEEE---------HHHHHHHHHH---EEEEEE--HHHHHHHHHH----EEEEEEE----EEE--HHHHHHHHHHHHHHHH----------EEEEEE-EEEEEEE---------------------EEEEE----HHHEEEEEEEE------------EEEEEEEEEE-----EEEEE----------EEEEEEEEEEE-- CLP1_2 prof ------------EEEEE----EEEEEE-----EEEEEE---EEEEEE-------EE-----EEEEEEE---EEEEE----EEEE-----HHHHHHHHHHHHHHHHHH--------EEEEE------HHHHHHHHHHHHHHHHHHHHHHHHH---------EEEE----------HHHHHHHHHH----EEEEE----HHHHHHH------EEEEE------E---HHHHHHHHHH--EEE----------EEEEEE---EEEEEE---------------------EEEE----------EEEE------HHHHH----EEEEEEEEE-----EEEEEE---------EEEE--------- CLP1_2 jnet ------------EEEEE----EEEEEE----EEEEEEE--EEEEE--------EEEE----EEEEEE----EEEEE-----EEE-----HHHHHHHHHHHHHHHHHHHH------EEEEE-----------HHHHHHHHHHHHHHHHHHHH-----------EE-----------HHHHHHHHH----EEEEE--HHHHHHHHHH-----EEEEE-----EE---HHHHHHHHHHHHHHHH----------EEEEEE--EEEEEE----------------------EE-----HHHHHHEEEEEE----HHHHHH----EEEEEEEE-----EEEEEE---------EEEEEEEEE---- CLP1_2 sable -----------EEEEEE----EEEEEE----EEEEEEEE-EEEEE-------EEEEE----EEEEEE----EEEEE-----EEE-----HHHHHHHHHHHHHHHHHHH------EEEEEE----------HHHHHHHHHHHHHHHHHHHHH-------HEEEEEE---EE----HHHHHHHHHH----EEEEE--HHHHHHHHHH----EEEEEEE-EE-EE---HHHHHHHHHHHHHHHHH-------EEEEEEE---EEEEEE---------------------EEEEE--------EEEEEE------HHHHH---EEEEEEEEEE----EEEEEE---------EEEEEEEEEE--- CLP1_2 proteus ---HH-------EEEE-----EEEEEE-----EEEEEEE-EEEEE--------EEE-----EEEEEEE---EEEEE----EEE------HHHHHHHHHHHHHHHHHHHH------EEEEE---------HHHHHHHHHHHHH-HHHHHHHH--------EEEEE---------HHHHHHHHHHH----EEEEE-HHHHHHHHHHH----EEEEEE-----EE---HHHHHHHHHHHHHHHH----------EEEEE---EEEEEE---------------------EEEE----HHHHHEEEEEEE----HHH-----EEEEEEEEE------EEEEE----------EEEEEEEEE---- CLP1_2 sspro4 -----------EEEEEE----EEEEEE----EEEEEEEE-EEEE---E----EEEEE---EEEEEEE----EEEEEE----EEE-----HHHHHHHHHHHHHHHHHHH-------EEEEE----------HHHHHHHHHHHHHHHHHHHHHH----------EEE---EE----HHHHHHHHHH----EEEEE--HHHHHHHHHHH----EEEEE------EE--HHHHHHHHHHHHHHHH---------EEEEEE--EEEEEEE---------------------EEEE----HHHH-EEEEEE-----HHHHHH--EEEEEEEEEE-----EEEEEE---------EEEEE--EE---- CLP1_2 psspred -----------EEEEEE---EEEEEEE----EEEEEE---EEEEE-EE----EEEEEE--EEEEEEE---EEEEEE-EEEEEEE-----HHHHHHHHHHHHHHHHHHHHHHHH--EEEEE--------HHHHHHHHHHHHHHHHHHHHHHHHH--------EEEE--------HHHHHHHHHHHH---EEEEE--HHHHHHHHHH----EEEEEE------EE--HHHHHHHHHHHHHHHH--------EEEEEEE--EEEEEEE---------------------EEEE-----H---EEEEEE-----HHHHHH-----EEEE-EE-----EEEEEE---------EEEEEE--E---- CLP1_2 spineX ------------------------E-------EEEEEEE-EEEEE--------EEEE---EEEEEE-----EEEEE------------HHHHHH---HHHH--------------EEEEE-------HHHHHHHHHHHHHHHHHHHHHHH-----H-----EEEE---EE-----HHHHHH-------EEEE---HHHHHHHHH-----EEEEEEE-----EE----HHHHHHHHEEEEEE------E---EEEEE---EEEEE----------------------EEEEE---HHHH--EEEE------HHHHHHHHHH--EEEEE------EEEEEE---------EEEEEEEEEE--- CLP1_2 raptorxss ------------EEEEE----EEEEEE----EEEEEEEE-EEEE---E-----EEEE---EEEEEEEE---EEEEEE---EEEE-----HHHHHHHHHHHHHHHHHHHH------EEEEE----------HHHHHHHHHH---HHHHHHH----HHHH----EEE---EE-----HHHHHHHHH----EEEEE--HHHHHHHHHH-----EEEEE----------HHHHHHHHHHHHHHH--------E-EEEEE----EEEEEE---------------------EEEE----------EEEEE-----HHHHHH--H-HHHHHHEE-----EEEEE----------EEEEE---E---- CLP1_2 SPARROW ------------EEEEE----EEEEEE----EEEEEE---EEEE--EEE----EEEE----EEEEEEE---EEEEE-------------HHHHHHHHHHHHHHHHHH--------EEEEE--------HHHHHHHHHHHHH-HHHHHHHHHH---HH-----E------E-------HHHHHHH----EEEEE--HHHHHHHHHH----EEEEEE-----EEE--HHHHHHHHHHHHHHHHH---------EEEEE---EEEEEE--------------------EEEEE----HHHH--EEEEE-----HHHHHH-----EEEEEEEE----EEEEEE---------EEEE--------- CLP1_2 *SPARROW --HHHHHH-----EEEE----EEEEEE----EEEEEEEE--EEEE--HH----EEEEE---EEEEEEE---EEEEEE----EEEE----HHHHHHHHHHHHHHHHHHHHH-----EEEEEE-------EHHHHH--HHHHHHHHHHHHHHHHH----E---EEEE----EE---HHHHHHHHHHH--EEEEEEEHHHHHHHHHHHHHH-EEEEEE-----EEE-HHHHHHHHHHHHHHHHH-----------EEEE-EEEEEEEE---------------------EEEE---HHHHHHHHHHHHH----HHHHHHHEE-EEEEEEE--H---EEEEE----------EEEEEEEEEEHHH CLP1_2 HMMSTR ------------EEEEE----EEEEEE-----EEEEEEE-EEEEE--EE----EEEE----EEEEEEEEEEEEEEE---EEEEE-----HHHHHHHHHHHHHHHHHHHHH-----EEEEE---------HHHHHHHHHHHHHHHHHHHHHH----------EEEE---------HHHHHHHHHH----EEEEE--HHHHHHHHHH-----EEEEE----------HHHHHHHHHHHHHHHHH-----E--EEEEEE---EEEEEE---------------------EEEE----HHH--EEEEEE-----HHHH----EEEEEEEEEEE----EEEEEE----------EEEEEEEE---- CLP1_2 porter -----------EEEEEE----EEEEEE----EEEEEEE--EEEEE-EE-----EEE-----EEEEEEE--EEEEEEEEEEEEEEE----HHHHHHHHHHHHHHHHHHHHH-----EEEEE--------HHHHHHHHHHHHH-HHHHHHHHH---------EEEE-----E---HHHHHHHHHHHH---EEEEE--HHHHHHHHHH----EEEEEE-----EEE--HHHHHHHHHHHHHHHH---------EEEEEE--EEEEEEE--------------------EEEEE----HHHH-EEEEEE-----HHHH-----EEEEEEEEE-----EEEEE----------EEEEEEEEEEE-- CLP1_2 spine -------------EEEE----EEEEEE---HHHHHHHHHHHHHHH---------EEE-----EEEEEE----EEE---EEEEEE-----EEEEE--HHHHHHHHHHHHHHHH---EEEEE-------HHHHHHHHHHHHHHHHHHHHHHHH----------EEE----------HHHHHHHHHH----EEEEE--HHHHHHHHH----EEEEEEE-----EEHHHHHHHHHHHHHHHHHHH-------------------EEEE----------------------EEEE------HHHHHHHHH-----HHHHHH----EEEEEE-------EEEEE-----------EEEEEEEE---- CLP1_2 nnssp -------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----------------EEEEEEE--EEEEEE--EEEEEE-----EEEEE--HHHHHHHHHHHHHHHH---EEEEE------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------------------HHHHHHHHHH----EEEEE-HHHHHHHHHHH----EEEEEE----------HHHHHHHHHHHHHHHHH--------------HHHEEEEE--------------------EEEEEE-------EEEEEEEE----------------EEEEEE------EEEEE--------HHHHHHHHHHHHH-- CLP1_2 pssfinder HHH----------EEE-----EEE--------HHHHHHHHHHHHH---------EEE----EEEEEE-----EEE----EEEEE-----EEEE---HHHHHHHHHHHHHHH----EEEEEE------HHHHHHHHHHHH-HHHHHHHHHH----------EEEEEE--------HHHHHHHHH-----EEEEE--HHHHHHHHHH---EEEEEEE-----EEE-HHHHHHHHHHHHHHHHH------EE-----EEE--EEEEEE-------------------EEEEEE-----HHHHHHH--------HHH-------EEEEEE------EEEEEE----------EEEEEE------- CLP1_2 sspal ---------------HHHHHHHHHEEE-HHHHHHHHHHHHHHHHH---------EEEE----EEEEEEE-EEEEE---EEEEEEE----HHHHHHHHHHHHHHHHHH---------EEEE--------EEEEEEE----HHHHHHHHHH-------EEEEEEEE----------HHHHHHHHEEEEEEEEEEEHHHHHHHHHHH----EEEEEEE-----HHHHHHHHHHH--HHHHHHHHH--------EEEEEEE--EEEEEEE-------------HHHHHHEEEEEEE--HHHHHHHHH--------------EEEEEEEEE-----EEEEEEEE---------EEEEE-------- CLP1_2 ssp -----------EEEEEE----EEEEEEE---EEEEEEEE-EE-EE-------EEEEEE----EEEEEE-EEEEEEEE----EE------HHHHHHHHHHHHHHHHHHH-------EEEEE---------HHHHHHHHHHHHHHHHHHHHHH---------EEEEE--------HHHHHHHHHHHH-HEEEEEE---HHHHHHHH-------EEEE-----EEEE-HHHHHHHHHHHH-HEH-----EE--EEEEE-E-EEEEEEE--------------------EEEEE-----HHHHHEEEEEE------HHH----EEEEEEEEE----EEEEEE----------EEEEEE-EEE--- CLP1_2 sspred -----------EEEEEE----EEEEEE----EEEEEEEE--EEEE--------EEEE----EEEEEEE---EEEEE------------HHHHHHHHHHHHHHHHHH---------EEEEE-----------HHHHHHHHHHHHHHHHHHHH-----------------------HHHHHHHHH-----EEEEE--HHHHHHHHHHH---EEEEE------EEE--HHHHHHHHHHHHHHHH----------EEEEE---EEEEEE---------------------EEEEE--------EEEEEE------HHHH----EEEEEEEEE-----EEEEEE---------EEEEE-------- CLP1_2 netsurfp ------------EEEEE----EEEEEE----EEEEEEEE-EEEE---------EEEE----EEEEEE----EEEEE----EEEE-----HHHHHHHHHHHHHHHHHHHHH-----EEEEE------------HHHHHHHHHHHHHHHHHHHHH---------EEE---------HHHHHHHHHHH---EEEEE--HHHHHHHHHHH---EEEEEE------E---HHHHHHHHHHHHHHHHH-----E--EEEEEE--EEEEEEE-------HH------------EEEE----HHHH--EEEEE-----HHHHHH---EEEEEEE-------EEEEEE---------EEEEEEEEE---- CLP1_2 soprano ------------EEEEE----EEEEEE----EEEEEEEE-EEEEE--------EEEE----EEEEEEE---EEEEE----EEEE-----HHHHHHHHHHHHHHHHHHHH------EEEEE--------HHHHHHHHHHHHHHHHHHHHHHH----------EEEE---------HHHHHHHHHH----EEEEE--HHHHHHHHHH----EEEEEE-----EEE--HHHHHHHHHHHHHHHH---------EEEEEE---EEEEEE---------------------EEEE-----HHH-EEEEEE-----HHHHHH---EEEEEEEEE-----EEEEEE---------EEEEEEEEE---- CLP1_2 consensus MSAGEVERLVSELSGGTGGDEEEEWLYGDENEVERPEEENASANPPSGIEDETAENGVPKPKVTETEDDSDSDSDDDEDDVHVTIGDIKTGAPQYGSYGTAPVNLNIKTGGRVYGTTGTKVKGVDLDAPGSINGVPLLEVDLDSFEDKPWRKPGADLSDYFNYGFNEDTWKAYCEKQKRIRMGLEVIPVTSTTNKITAEDCTMEVTPGAEIQDGRFNLFKVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTASRKANSSVGKWQDRYGRAESPDLRRLPGAIDVIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFLPPPPTVSTAPPLIPPPGK FIP1L1_4 sequence --HHHHHHHHHH---------------------------------------------------------------------EEEE----------------------------------------------------EEE--------------------------HHHHHHHHHHHHHHHH----------------------------------------------------------------------------------------------------------------------------EE---------------------------------------------------------------------- FIP1L1_4 psipred --HHHH--------------------------------------------------------------------------EEEEEE-------------------------------------EE----------EEEEEE-------------------------HHHHHHHHHHHHHHHHH-----EEE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- FIP1L1_4 prof ----------------------------------------------------------------------------------EE----------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- FIP1L1_4 jnet ---------HH-----------HH---------------------------------------------------------EEEEEE-------------------------------------------------EEEE-HHHH-------------EEE-----HHHHHHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- FIP1L1_4 sable ---HHHHHHHHH--------------------------------------------------------------------EEEEE--------------------------------------------------EEEEE--------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- FIP1L1_4 proteus -------EEEEEE-------HHHHHH------EE-----HH--------HHHHHH-------------------------EEEEEEE-------------------------E----------------------EEEEE-HHHH------------HHHH-----HHHHHHHHHHHHHHHH---------------------------EE----EEEEEEE---------EEE-----------------------------------------------------------------EE--EEEEEEEE------------EEEE--------------------------------------------------- FIP1L1_4 sspro4 --HHHH--HHHHH--------HHHH-------------------------------------------------------EEEEE-------------------------------------------------EEEEEE----------------HHHH-------HHHHHHHHHHHHHHHH------HHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- FIP1L1_4 psspred --HHHHHHHHHHHH------HHHHHHH--------HHHHHH------------HH-------------------------EEEE---------------------------------------------------EEEE--HHH------------HHH-H-----HHHHHHHHHHHHHHHHH-----HHHHH------------------------H-----------------------------------------------------------------------------------------HHHHHHH---------------------------------------------------------------- FIP1L1_4 spineX -----HHHHH-----------HHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ FIP1L1_4 raptorxss --H----HHHHHH---------HH--------------------------------------------------------EEEEE--------------------------------------------------EEEEEEH-H------------HHHHE-----HHHHHHHHHHHHHHHHH--HHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- FIP1L1_4 SPARROW --------H-------------HHH------------------------------------------------------------------------------------------------------------------------------------HHH------H-HHHHHHHHHHHHH-HH-HHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- FIP1L1_4 *SPARROW --HHHHHHHHHHHHHHHHH-HHHHHH-------------------------------------------------------EEEEE---------------------------------------------E----EEE--HHH------------EE-HE-E---HHHHHHHHHHHHHHHHHH--HHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- FIP1L1_4 HMMSTR ---HHHHHHHHHH--------HHHHH----------HHHH---------HHHHHH-------------------------EEEEE---------------------------E------------------------EEEEHHHH-----------HHHHHH----HHHHHHHHHHHHHHHH----EEE--------HHH-----------------------------HHHHH------------------------------------------------------------------------E----------------------------------------------------------------------- FIP1L1_4 porter -----HHHHHHHH--------HHHHHH-------HHHHH----------HHHHHHH------------------------EEEEEE----------------EEEEE----EEE----------------------EEEE-----------------------------HHHHHHHHHHHHH--EEEEEE---------------------------EEEEEE-----------------------------------------HHHHHH----------------------------EEEE--EEEEEHHHHHHHH-----EEEE---------------------------------------------------- FIP1L1_4 cdm -----HHHHHHHH--------HHHHHH-------HHHHH----------HHHHHHH------------------------EEEEEE----------------EEEEE----EEE----------------------EEEE-----------------------------HHHHHHHHHHHHH--EEEEEE---------------------------EEEEEE-----------------------------------------HHHHHH----------------------------EEEE--EEEEEHHHHHHHH-----EEEE---------------------------------------------------- FIP1L1_4 fdm HHHHHHHHHHHHHHHHHHHHHHHHHHHH----------------------------------------------------------HHHH---------HHHHHHHHHHHHHHH----------------------HH--EEE-------------HHHHH--------HHHHHHHHHHH--------EE---EEE------EEE-----------EEE----EEE---HHHHHHHH---HHH-HHHHHHH-------------------EE-------HH--HH-HHH--HHHHHH---HHH-HH---HHHHHHH-----EEEEEE--------------------------------------------------- FIP1L1_4 gor ---HHHHHHHHHH--------HHHHH----------HHHH----------------------------------------EEEEE--------------------------------------EEEE---------EEEE-HHH------------HHHHH-----HHHHHHHHHHHHHHHEE-E----------EEEEE-----------------HHHH----------------------------------------------------------EEE---------------EEEEEEEEEEEEEEEEEE-------EEEEEE-------------------------------------------------- FIP1L1_4 spine --HHHHHHHHHH------------EEE-----------------------------------------------------EEEEE------------------EEEE-----EEE----------------------EEE-------------------------------------------EEEEE-------------EEEE----------EEEEEE------------------------------------------------------------------------------EE---EEEEE-------------EEEE---------------------------------------------------- FIP1L1_4 nnssp --HHHHHHHHHHHH------HHHHHHH-----------------------------------------------------EEEEE-----------------EEEEE----EEEE----EEEEEEE----------EEEE-HHH------------HHHHHH----HHHHHHHHHHHHHHHH--EEEEE--------------------------EEEEEEEE---------------------------------------------------------------------------------EEEEE-------------EEEEE--------------------------------------------------- FIP1L1_4 pssfinder --HHHHHHHHHH---------------------------------------------------EE---------------EEEEE------------------EEEEE---EEEEE---EEE-EE------EEEEE-EEEEEE----------------------------EE-------EEEEEEEEE-----------EEEEEE----------EEEEE-----------------EE--------------------------EEEE-------EE-EE---------------EEEEE-EEEEEEEEE----------HHHHHH--HHH--------------------------------------------- FIP1L1_4 sspal ----HHHHHHHHH------HHHHHHHHH----------------------------------------------------EEEEE-----------------EEEEEEE--EEEE---------------------EEEEEEE-----------------------HHHHHHHHH--------EEEEEEE---------EEEEEEE------------------------------------------------------------------------------------HHHHH-----EEEEEEEEEHHHHHHHHHH---EEEE--------------------------------------EEEE---------- FIP1L1_4 ssp -----HHHHHHHHH----------HE-------------------------------------------------------EEEEE-------------------------------------------------EEEEE--------------------------HHHHHHHHHHHH----------HH----------------------------------------------------------HH-----------------------------------------------EEEEEEEEEEEE--------------EEEE--------------------------------------------------- FIP1L1_4 sspred ---HHHHHHHHH---------------------------------------------------------------------EEEE---------------------------------------------------EEE--------------------HH-----HHHHHHHHHHHHHHHHH----HHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- FIP1L1_4 netsurfp -----HHH-HHHH---------HHHH-------------------------------------------------------EEEE--------------------------------------------------EEEE--HHHH--------------HHH----HH-HHHHHHHHHHHHHHH-H-HHHHHH---------------------------------EE------------------------------------------------------------------------------------------------------------------------------------------------------ FIP1L1_4 soprano ---HHHHHHHHHH--------HHHH-------------------------------------------------------EEEEE---------------------------------------------------EEEE--------------------------HHHHHHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- FIP1L1_4 consensus MFPNSILGRPPFTPNHQQHNNFFTLSPTVYSHQQLIDAQFNFQNADLSRAVSLQQLTYGNVSPIQTSASPLFRGRKRLSDEKNLPLDGKRQRFHSPHQEPTVVNQIVPLSGERRYSMPPLFHTHYVPDIVRCVPPFREIAFLEPREITLPEAKDKLSQQILELFETCQQQISDLKKKELCRTQLQREIQLLFPQSRLFLVGSSLNGFGTRSSDGDLCLVVKEEPVNQKTEARHILTLVHKHFCTRLSGYIERPQLIRAKVPIVKFRDKVSCVEFDLNVNNIVGIRNTFLLRTYAYLENRVRPLVLVIKKWASHHQINDASRGTLSSYSLVLMVLHYLQTLPEPILPSLQKIYPESFSPAIQLHLVHQAPCNVPPYLSKNESNLGDLLLGFLKYYATEFDWNSQMISVREAKAIPRPDGIEWRNKYICVEEPFDGTNTARAVHEKQKFDMIKDQFLKSWHRLKNKRDLNSILPVRAAVLKR PAPD4_2 sequence ------------------------------------HHHHH-------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH----EEEEE-------------EEEEEEE-------HHHHHHHHHHHHHHHHHH----------------EEEEEE----EEEEEEEE--HHHHHHHHHHHHHH----HHHHHHHHHHHHHH------------HHHHHHHHHHHHH--------------------HHHH--------------------HHHHHHHHHHHH---------EEEE-----EE-----------EEEE--------------HHHHHHHHHHHHHHHHHHH-----------HHHHH-- PAPD4_2 psipred -------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH----EEEEEE--------------EEEEE-------HHHHHHHHHHHHHHHHHH----EEEEEEEE--EEEEEEE-----EEEEE----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHHH--------HHH------------------------------HHHHHHHHHHHHHHHHH-----EEEEEE----------------EEEEE--------------HHHHHHHHHHHHHHHHHHH----HHHHH-HHHHH--- PAPD4_2 prof -----------------------------------------------------------------------------------------------------EEEEE----------------------------------------------HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHH-----EEEEEEEE---------EEEEEEE----------HHHHHHHHHHHHHH---------E-----EEEEEEE-----EEEEEEE--HHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHH-----------HHHHHHHHHHHHH-------------------------------------------HHHHHHHHHHHHHH--------EEEEEE----------------EEEEE--------------HHHHHHHHHHHHHHHHHHH----------HHHH---- PAPD4_2 jnet ---------------------------------HH-------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHH----EEEEE--------------EEEEE---------HHHHHHHHHHHHHHHHH----EEEEEE----EEEEEEE-----EEEEEEE----HHHHHHHHHHHHHH--HHHHHHHHHHHHHHH------------HHHHHHHHHHHHH-------------------------------------------HHHHHHHHHHHHHHH-------EEEEE----------------EEEEE--------------HHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHH-- PAPD4_2 sable --------------------------------HHHH-------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH---EEEEEE-------------EEEEEE--------HHHHHHHHHHHHHHHHH----EEEEEEEE----EEEEEE-----EEEEEEE---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------E-HHHHHHHHHHHHH---------HHH-------------EE-----E----------HHHHHHHHHHHHHHHEE---EEEEE----EHH-----------EEEEEE-------------HHHHHHHHHHHHHHHHHHHH---HHHH----HHHH-- PAPD4_2 proteus ------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH----EEEEE-------------EEEEEE-------HHHHHHHHHHHHHHHHHH-----EEEEEEE----EEEEEEE-----EEEEEE---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHH---------HHHH-HHH--------------------------HHHHHHHHHHHHHHHH------EEEE---EEE------------EEEE--------------HHHHHHHHHHHHHHHHHHHH---HHHH---HHHHH-- PAPD4_2 psspred -------------------------------HHHHHHHHHH-H--HH-----------------------------------------------------------------------------------------HH-----------HHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH----EEEEE--------------EEEEEE-------HHHHHHHHHHHHHHHHHH---EEEE--------EEEEEEE----EEEEEEEE-HHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHH--------HHH-------------E-----------------HHHHHHHHHHHHHHHH-----EEEEEE--EEEE----------EEEEE--------------HHHHHHHHHHHHHHHHHHHH---HHH---HHHHHHH- PAPD4_2 spineX -----------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHH-----EEEEE---------------EEEEE--------HHHHHHHHHHHHHHH------EEEEEEEEEEEEEEEEE-----EEEE-----HHHHHHHHHHHHHHHH----HHHHHHHHHHHHH------------HHHHHHHHHHHHHH--------------------EEEEEEE----------------HHHHHHHHHHHHHH------EEEEE-----E-----------EEEEE--------------HHHHHHHHHHHHHHHHHHH----HHH----------- PAPD4_2 raptorxss ----------------------------------------------------------------------------------------------------------------------------------------HH------------HHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHH----EEEEEEEE-H-H------EEEEEE--------HHHHHHHHHHHHHHHHH-----EEEEEE-----EEEEEEE----EEEEEEE----HHHHHHHHHHHHHH----HHHHHHHHHHHHH------------HHHHHHHHHHHHH---------HHHH------------HH-----------------HHHHHHHHHHHHH-EE-----EEE-E--EEEE----------EEEEE--------------HHHHHHHHHHHHHHHHHHH----HHHH----HHHH-- PAPD4_2 SPARROW -----------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH----EEEEE--------------EEEEE---------HHHHHHHHHHHHHHHH-------EEEE-E--E-EEEEEE----EEEEEE---HHHHHHHHHHHHHHHH---HHHHHHHHHHHHHH------------HHHHHHHHHHHHHH---------HH-------------------------------HHHHHHHHHHHHHHH-------EEE-----EE----H-------EE----------------HHHHHHHHHHHHHHHHHHH----HHHH----HHHH-- PAPD4_2 *SPARROW --------------------------------------------------------------------------------------HHHHHEE--------------------------------------------------------HHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHH-----EEEEEE--------------EEEEEE---HHHHHHHHHHHHHHHHHHHHH----HHEEEE-------EEEE------EEEEEEE-EEEEEHHHHHHHHHHH---HHHHHHHHHHHHHHH-E-------EEHHEEEEEHHHHHHH--------HHHHHHHH------EEEHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHE-----EEEEE----EE-HHHHHH----EEEEE--------------HHHHHHHHHHHHHHHHHH-HHH-HHHHHHHHHHHHHH PAPD4_2 HMMSTR ----------------------EE----E--HHHHHHHH-------HHHHHHHHHH----------------------------------EEEE------EEEEEE--------------------------------------------HHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH-----EEEE--H----------EEEEEE-------HHHHHHHHHHHHHHHHHH-------EEEE-EEE--EEEEE-------EEEEE---HHHHHHHHHHHHHHH--HHHHHHHHHHHHHHH----------E-HHHHHHHHHHHHHH-------------HH-------------------------HHHHHHHHHHHHHHHHH------EEEE------E--------------EE--------------HHHHHHHHHHHHHHHHHHH----HHHH---HHHHH-- PAPD4_2 porter ------------------------------------------------HHHHH---------------------------------------------------------------------------------------------------HHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHH----EEEEE----EEE-------EEEEE--------HHHHHHHHHHHHHHHHH----HHHHHHH------EEEE-------EEEEEE------HHHHHHHHH-------HHHHHHHHHHHHH--------------HHHHHHHHHH---------------------------------------------HHHHHHHHHHH----------EEEE-----------------EEEE-----------------HHHHHHHHHHHHHHHHH------------------ PAPD4_2 cdm ------------------------------------------------HHHHH---------------------------------------------------------------------------------------------------HHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHH----EEEEE----EEE-------EEEEE--------HHHHHHHHHHHHHHHHH----HHHHHHH------EEEE-------EEEEEE------HHHHHHHHH-------HHHHHHHHHHHHH--------------HHHHHHHHHH---------------------------------------------HHHHHHHHHHH----------EEEE-----------------EEEE-----------------HHHHHHHHHHHHHHHHH------------------ PAPD4_2 fdm --HHH---EE---HHHHH----------------HHHHHHHHHHHHHHHEEEHH--------HHH-------------EEEEE---------HHHHHHHHHHH-HHHHHH-----HHHHHHHHH--------HHHHHHH--------------HHHHHHHHHHHHH----------HHHHHHHHHHHHH------EEEEEHHHHH--------EEEEEE--------HHHHHHHHHHHHHHHHHH----EE-EEEE-----EEEEE------EEEEE-----HHHHHHHHHHHHHH-HHHHHHHHHHHHHHHH------------HHHHHHHHHHHHHH-HHHHHHHHHHH-HHHHHHHHHHH-------------------HHHHHHHHH-HHHH------EEE-------EEHH-----HHEE-EEE------------HHHHHHHHHHHHHHHHHHHHHH-----HHH--------- PAPD4_2 gor ---------------HHHH------------HHHHHHHHH-------------------------------------------------EEEEE--------E--EEE---------------------------HHH------------HHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH----EEEEEEEEE----------EEEEE--------HHHHHHHHHHHHHHHHHH----E--EE----E--EEEEEE-----EEEEEE---HHHHHHHHHHHHHHH---HHHHHHHHHHHHHH------------HHHHHHHHHHHHHH-----------------------------------------HHHHHHHHHHHHHHHH------EEEEEE---EEE----------EEEEE-------------HHHHHHHHHHHHHHHHHHHHH---HHH----HHHH--- PAPD4_2 spine ----------------------EEE------HHHHHHHHH------HHHHHHHHHH-----------------------------------EE--------EEEEE---------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----EEEE---------------EEEEE---------HHHHHHHHHHHHHHHH----------------EEEE----EEEEEE-----EEE----HHHHHHHHHH-----EEEEE------------------HHHHHHHHHHHHH---------------------HHHHH------------------HHHHHHHHHHHH----------EE------------------EEEE--------HHHHHHHH-HHHHHHHHHHHHHHHH-----------HHHHHHHH PAPD4_2 nnssp -------------------------------HHHHHHHHH------HHHHHHHHHHH-------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----EEEEE---------------EEEEEE------HHHHHHHHHHHHHHHHHH-------HHHHH----EEEE--EEEEEEEE--------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------------HHHHHHHHHHHHHH------HHHHHH------HHHHHHHHH----------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------------EEEEEE------HHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHH-- PAPD4_2 pssfinder ---------------------EEE-------HHHHHHHHH--------HHHHHHH--------------HHHH-----------------EEE-------EEEEEEE------------EEEE-----EEEEE--------------------HHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHH-----EEEE---------------EEEEEE--------HHHHHHHHHHHH-------------EEE--EEEEEE--EEEEEEEE----EEE-----EEEEEHHHHH-----EEEEHHHH-----------------HHHHHHHHH-----------HHHH---------EE-EE-----------------HHHHHHHHHHHH--------EEEEE-------------EE--EEEEEE------HHHHHHH---HHHHHHHHHHHHHHHH----------HHHHHHH- PAPD4_2 sspal ----EEEE-------------------EEEE-HHHHHHHHH--------------EEEE-----------------------------------------EEEEEEEE-----------EEEEEEE--EEEEE--HHHHHHHHH---HHHHHHHHHHHHHHHHH---HHHHHHHHH--HHHHHHHHHHHHHH----EEEE---------------EEEEEEE----HHHHHHHHHHHHHHEEE-------------------------EEEEEEE-----------HHHHHHHHHHHHHEEEEEEEE------------------EEEEEEEEE---------HHHHHHHHH-------EEEEEEE---------HHHHHHHHHHHHHHHHHH---------HHHHHHHHH-------------EEEE-------HHHHHHHHH---HHHHHHHHHHHHHHHH---HHHHHHHHHHHHHH PAPD4_2 ssp ---------------------HHH-------HHHHHHHHHHHH------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH---EEEEEEEEE----------EEEEEEE-------HHHHHHHHHHHHHHHHH-----EEEEEEE----EEEEEEE----EEEEEEEE-----HHHHHHHHHHH----HHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHH-------------------------------------------HHHHHHHHHHHHHH-------EEEEE----------------EEEEE---------------HHHHHHHHHHHHHHHHHH-----------HHH---- PAPD4_2 sspred -----------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHH----EEEEEEE-----------EEEEEE--------HHHHHHHHHHHHHHHHH---------------E-EEEEEE----EEEEEEE----HHHHHHHHHHHHHH---HHHHHHHHHHHHHH------------HHHHHHHHHHHHHH--------HHHH----------------------------HHHHHHHHHHHHHHHH--------EEEE----EE------------EEEE--------------HHHHHHHHHHHHHHHHHHHH-----------HHHH-- PAPD4_2 netsurfp --------------------------------HHHHH-----------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH----EEEEEE-EE---E-----EEEEEE-----------HHHHHHHHHHHHHH-----EEEEEEEE--EEEEEEEE----EEEEEEE----HHHHHHHHHHHHHH--HHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHH--------HHHHHHH---------EE-----------------HHHHHHHHHHHHHHHHHH---EEEE----EEE----------EEEEE--------------HHHHHHHHHHHHHHHHHHHH---HHHHH---HHHH-- PAPD4_2 soprano ----------------------------------H-------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH----EEEEE--------------EEEEE--------HHHHHHHHHHHHHHHHH-----E-EEEE------EEEEE-----EEEEEEE----HHHHHHHHHHHHHH---HHHHHHHHHHHHHH------------HHHHHHHHHHHHHH--------HHH-------------------------------HHHHHHHHHHHHHHH-------EEEE-----E-----------EEEEE--------------HHHHHHHHHHHHHHHHHHH----HHHH---HHHHH-- PAPD4_2 consensus MYRTKVGLKDRQQLYKLIISQLLYDGYISIANGLINEIKPQSVCAPSEQLLHLIKLGMENDDTAVQYAIGRSDTVAPGTGIDLEFDADVQTMSPEASEYETCYVTSHKGPCRVATYSRDGQLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENHPVIRTLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLVRYTGAGLSGRQVHRTQAVFNHTEDYVLLPDERTISLCCWDSRTAERRNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFRARFWYRRSTTD CSTF1_1 sequence ---------HHHHHHHHHHHHHHH--HHHHHHHHHH-----------HHHHHHHHH-------EEEEE----EEE-------------EEEE------EEEEEEE-----EEEEEE-----EEEE------EEEEE------------EEEE------------EEE--------EEEEEE-----EEEEE-----EEEEE-----EEEE---------EEEEEE-----EEEEE-----EEEEE-----EEEE----------EEEEEE-----EEEE------EEEEE-----EE-----------EEEEEE-----EEEEEE----EEEEE-----EEEEEE----------EEEEEEE----EEEEE-----EEEEEE-----EE----------EEEEEE-----EEEEEE----EEEEE------ CSTF1_1 psipred ---HHHHHHHHHHHHHHHH--EEE-----EEEEEEEE----EEEE----HHHHHH------EEEEEE-----EEEE-----------EEEEEE----------------EEEEEEE----EEEEE-----EEEEEE----------EEEEEE-----------------------EEEEEE----EEEEE-----EEEEEE-----EEEEEEE-----EEEEEEE-----EEEE-----EEEEEE-----EEE----------EEEEEEE-----EEEE-----EEEEEE-----EEE---------EEEEEEE-----EEEE-----EEEEEE-----EEEEE-----------EEEEEEE----EEEEE-----EEEEEE----------------EEEEEEE-----EEEE-----EEEEEE------ CSTF1_1 prof -HHHHHHHHH--HHHHHHHHHHHHH-----EEEEEEE----EEEEE-----EEEEEE----EEEEEE-----EEEEE----------EEEEEE-----EEEEEEE-----EEEEEE-----EEEEE----EEEEEE----------EEEEEE-------------EEEEE-----EEEEEE-----EEEEE----EEEEEE-------EEEEEE-----EEEEEE-----EEEEE----EEEEEE-----EE------------EEEEEE-----EEEEE----EEEEEE-----E---EEE------EEEEEE-----EEEE-----EEEEEE-----EEEEE-----------EEEEEEE----EEEEE-----EEEEEE-----------------EEEEEE-----EEEEE----EEEEEE------ CSTF1_1 jnet ----HHHHHHHHHHHHHHHHHHH----HHHHHEEHHE----------------EEE------EEEEE------EEE-----------EEEEE--------EEEE------EEEEEE-----EEEE-----EEEEE-----------------------------EEEEE------EEEEEE-----EEEE-----EEEEEE-------EE--------EEEEEEE-----EEEEE----EEEEEE-----EEEE----------EEEEEE-----EEEEE-----EEEEE----HHEEE--------EEEEEEE-----EEEE-----EEEEEE-----EEEEE----------EEEEEEEE----EEEEE-----EEEEE------HHH---------EEEEEE-----EEEEE----EEEEEE-----H CSTF1_1 sable ----HHHHHHHHHHHHHHHHH-----EEEEEEE---EEE-----------EEEEEE-----EEEEEEE----EEEE-----------EEEEEE-----EEEEEEE-----EEEEEE----EEEEEE----EEEEEE----EE-----EEEE---EEE-------EEEEEE----EEEEEEEE---EEEEEEE---EEEEEE-----EEEEEEE-----EEEEEEEE---EEEEEE----EEEEEEE---EEEEEE--------EEEEEEEE---EEEEEEE---EEEEEE-----EEEEE------EEEEEEEEE----EEEEE----EEEEEE----EEEEEEE-EEE-----EEEEEEEE----EEEEEE---EEEEEEEE---EEEEEE-----EEEEEEEEE---EEEEEEE---EEEEEEE----- CSTF1_1 proteus ----------HHHHHHEEE--------EEEE-----EEEEEE-------HHHEEEE-----EEEEEEE-----EEE------------EEEEE-----EEEEEEE-----EEEEEE-----EEEEE----EEEEEE------EEEE-------EEEEEE-----EEEEE------EEEEEE-----EEEE-----EEEEEE-----EEEEEEE------EEEEEE-----EEEEE-----EEEEE-----EEEEEE--------EEEEEE-----EEEEE----EEEEEE-----EEEEE-------EEEEEEE-----EEEE-----EEEEEE-----EEEEEE-----EEEEEEEEEEEE-----EEE------EEEEEE-----EEEEEE-----EEEEEEE-----EEEE-----EEEEEE------ CSTF1_1 sspro4 ----HHHHHHHHHHHHHHHHH------EEEEEEEEEEE--------------EEE------EEEEEEE----EEEEE-----------EEEEE----EEEEEEEE-----EEEEEE-----EEEEEE---EEEEEE-----EE-----EEE------------EEEEEE------EEEEEE-----EEEEEE---EEEEEE-----EEEEEEE------EEEEEE-----EEEEEE---EEEEEE----EEEEE----------EEEEEE-----EEEEEE---EEEEEE----EEEEE--------EEEEEEE-----EEEEEE---EEEEEE----EEEEEEE----------EEEEEEE-----EEEEEE---EEEEEE----EEEE---------EEEEEE-----EEEEEE---EEEEEE------ CSTF1_1 psspred -------HHHHHHHHHHHHHHHHH----EEEEE----E---------HHHHHHHHH-----E-EEEEE----EEEE-----------EEEEEE-----EEEEE-------E-EEEEE----EEEEE----EEEEEE----EEEE----EEEE--------------EEE------E-EEEEE----EEEEE----EEEEEE-------EEEEE------E-EEEEE----EEEEE-----EEEEE----EEEEE----------E-EEEEE----EEEEE----EEEEEE----EE-E---------EE-EEEEE----EEEEEE---EEEEEE-----E-EEEE---------EEEEEEEE----EEEE------EEEEEE-----EHHHHHH-------EEEEE----EEEEE----EEEEEE------ CSTF1_1 spineX -EEEE-----EEEEE-----EEEE------EEEEEEEE-----EE-------EEEE-------EEEE-----EEEE------------EEEE----------E-------EEEEEE-----EEEE-----EEEEE------------EEEEE-----E------EEEE--------EEEEE-----EEE------EEEEE-------EE----------EEEEEE-----EEEE-----EEEEE------EEE-----------EEEEEE-----EEEE-----EEEEE-------E-----------EEEEEE-----EEEE-----EEEEE------EEEEE-----------EEEEEE-----EEEE------EEEEE------------------EEEEEE-----EEEE-----EEEEE------- CSTF1_1 raptorxss ----HHHHHHHHHHHHHHHHHHHH---EHHHHHHHEEE-----------HH--EEE-----EEEEEE-----EEEEE-----------EEEEE-----EEE-EEE-----EEEEEE-----EEEEEE----EEEEE------EE----EEEE-----------EEEEEEE-----EEEEEE-----EEEEEE----EEEEE-----EEEEEEEE-----EEEEEE-----EEEEEE---EEEEEE----EEEEE----------EEEEEE-----EEEEEE----EEEEE-----EEE----------EEEEEE-----EEEEEE----EEEEE-----EEEEE-----------EEEEEE-----EEEEEE-----EEEEE-----EE---------EEEEEEE-----EEEEEE---EEEEEE------ CSTF1_1 SPARROW --------H---EEEE-----E--------EEEEEEEE------EE---------------EEEEEE-----EEEEE----------EEEEEE----EEE----------EEEEEE------E---E-E------E------E---EEEEEE-----E------E----------EEEEEE------EE--E--------E----EEEE----------EEEEEE--E--EE---E-E------E-----EEEE----------EEEEEE-------E--H-----E--E--H--EEE----------EEEEEE------E---HH-------E-----EEEE------------EEEEEEE-----EEE--HHH---E--E--H-EEE----------EEEEEE------E---HH----E--------- CSTF1_1 *SPARROW HHHHHHHHHHHHHHHHHHHHEEEEE----EEEEEEE-----EEEE-----H--EEEE---EEEEEEE-----EEEE-----------EEEEE------EEEE-------EEEEEEE-----EEEE-----EEEEEE---------EEEEEEE-----EEE-----EEE------EEEEEEE-----EEEE-----EEEEE------EEEE--------EEEEEEE-----EEEE-----EEEEE------EEEE---------EEEEEEE-----EEEE-----EEEEE------EEEE--------EEEEEEE-----EEEE-----EEEEE------EEEEEE----------EEEEEEE-----EEEE-----EEEEE------EEEE-------EEEEEEE-----EEEE-----EEEEE------E CSTF1_1 HMMSTR -------HHHHHHHHHHHHHHH----HHHHHHHHHHH------------HHHHHH-------EEEEEE------EE------------EEEE-------EEEEE------EEEEEE-----EEEEEE----EEEEE---------EEEEEEE------------EEEEEE-----EEEEEE-----EEEEEE----EEEEE-----EEEEEEE------EEEEEE-----EEEEEE----EEEEE-----EEEEEEEE------EEEEEE-----EEEEEE----EEEEE-----EEEEEE-------EEEEEE-----EEEEEE---EEEEEE-----EEEEEE----------EEEEEE------EEEEE----EEEEEE-----EEEEEE------EEEEEE-----EEEEEE---EEEEEE------ CSTF1_1 porter -------HHHHHHHHHHHHHHH-H---HHHHHHHH-----------HHHHHHHHH-------EEEEEEE-----E------------EEEEE-------EEEEEE-----EEEEEE-----EEEEE----EEEEEE-HHHHHH----HHHHHHHHHHH------EEEEEE-----EEEEEE-----EEEEE----EEEEEE-----EEEEEEE------EEEEEE-----EEEEEE---EEEEEE-----EEEEE---------EEEEEE-----EEEEE----EEEEEE----EEEEEEE------EEEEEEE-----EEEEE----EEEEEE-----EEEEE--------EEEEEEEEEE----EEEEEE----EEEEEE----EEEE---------EEEEEE-----EEEEE----EEEEEE------ CSTF1_1 spine EE--------HHHHHHHHHHHHHH----------------------HHHHHHHHHH--------EEEEE------------------------------EEEEEE------EEEEE----EEEE------HHHHHHHHHHHHH----HHHHHHHHHHHHH----HHHHHHH----EEEE----------------HHHHH------HHHHHHHHHHHHHHHH--------EEEE-------EE------EEEEE---------EEEEE-------EEEE------EE--------HHHHHHHH-----EEEEE------EEE------HHHHHHH-----EEEE---------HHHHHHEE-----EEE-----EEEEEE------HHHHHHH------EEEEE-----------------EEEEE----- CSTF1_1 nnssp -------HHHHHHHHHHHHHHHHH--EEEEE---------------HHHHHHHHHH---HHH-EEEEEE-----------EEEEE-------------EEEEEEE----EEEEEEE-----EEEE--HHHHHHHHHHHHHHHHH---HHHHHHHHHHHHH----EEEEEE----EEEEEEE---HHHHH-----EEEEEEE-----HHHHHHHHHHHHHHHHH-------EEEE-------------EEEEEEE---------EEEEEE------EEE------EEEEEE----EEEEEEEEEE--EEEEEEEE-----EEEE--HHHHHHHHHHHH--EEEEEE---------------------EEE-----EEEEEEE----HHHHHHHHH----EEEEEEE------EEEE-HHHHHHHHHH----- CSTF1_1 pssfinder ----------HHHHHHHHHHHH----EEEEE-----------EEE-HHHHHHHHHHHH-----EEEEEE-----------EEEEE-------------EEEEEEE-------EEEE-----EEEEE-----EEEE------------HHHH----HHH-----EEEEEE--------EEEE-----EEEE------EEEEE-----HHHHHHHH-------EEEE-----EEEEE-----EEEEE----EEEEEE-----------EEEE-----EEEEE-----EEEEE----EEEEEE---------EEEEE-----EEEEE-----EEEEE-----EEEEE-------HHHHHHHEEE-----EEE-----EEEEEEE---------EEE-----EEEEEEE------EEEE-----EEEEEEE---- CSTF1_1 sspal -------HHHHHHHHHHH--------EEEEHHHHHHHHH--------HHHHHHHHH-------EEEEEEE------------------------------EEEEE-----EEEEEEE----------HHHHHHHHH-HHHHHHHHH-EEEEEHHHHHHHHHH--EEEEEEE----EEEEEEE--HHHHH-----EEEEEEE----HHHHHHHHHHHHHHHHEEEEE----EEEE-----------EEEEEEEEEE--------EEEEEEE-----EEEE-----EEEEE------HHHHHHHHH--HHHHHHHHH----EEEE---HHHHHHHHH---EEEEEEE------EEEE-----------EEEE----EEEEEEEHHHHHHHHHHH------EEEEEEE------EEEEEHHHHHHHHH------ CSTF1_1 ssp ----------HHHHHHHHHHHH-----EEEHH-HH-------------HHHHHHHH-----EEEEEEE------EEE----------EEEEEE-----EEEEEEE----EEEEEEE-----EEEEEE---EEEEEEEE--------------------------EEEEEE----EEEEEEEEE---EEEEE----EEEEEE-----EEEEEEE------EEEEEEEE---EEEEE----EEEEEE-----EEEEEEE-------EEEEEEE----EEEEE-----EEEEE-----EEEEE--------EEEEEE-----EEEEE-----EEEEE-----EEEEEE------EEEEEEEEEE-----EEEEEE----EEEEEE----EEEEEE-------EEEEEEE----EEEEE-----EEEEEE----- CSTF1_1 sspred ------------HEEEEE--------EEEEEEEE-EEE---------------EE------EEEEEE-----EEEEE----------EEEEE------------------EEEEEE-----EEEE-----EEEEEE-----------EEEEE------------EEE--------EEEEEE-----EEEE-----EEEEE-------E-----------EEEEEE-----EEEEE----EEEEEE------E------------EEEEEE-----EEEE-----EEEEE-------------------EEEEEE-----EEEE-----EEEEE------EEEE------------EEEEEEE----EEEEE-----EEEEE-----HHH----------EEEEEE-----EEEE-----EEEEEE------ CSTF1_1 netsurfp -----H-H--HHHH-EEHHH-HH----EEEEE-----E-----------HH--H-------EEEEEE------EEE------------EEEE-------EEEEEEE----EEEEEE-----EEEE-----EEEEEE----EEEE-----EEE------------EEEEEE-----EEEEEE-----EEEE-----EEEEEE------EEEEE-------EEEEEE-----EEEE-----EEEEEE-----EEEE----------EEEEEE-----EEEE-----EEEEEE-----EEEE--------EEEEEEE-----EEEE-----EEEEEE-----EEEEE-----------EEEEEEE----EEEEE-----EEEEEE-----EEEE--------EEEEEE-----EEEE-----EEEEEE------ CSTF1_1 soprano -------HHHHHHHHHHHHHHH-----EEEEEEE--E------------HHHHHH------EEEEEEE----EEEE------------EEEE------EEEEEEE-----EEEEEE-----EEEE-----EEEEEE-----------EEEEE------------EEEEE------EEEEEE-----EEEE-----EEEEEE-----EEEEEEE------EEEEEE-----EEEEE----EEEEEE-----EEEE----------EEEEEE-----EEEEE----EEEEEE-----EEEE---------EEEEEE-----EEEE-----EEEEEE-----EEEEE-----------EEEEEEE----EEEEE-----EEEEEE-----EEE---------EEEEEE-----EEEEE----EEEEEE------ CSTF1_1 consensus MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV PABP-1_1 sequence -----------EEEE--------HHHHHHHH-----EEEEEEEE---------EEEEEE--HHHHHHHHHH----------EEEEE--------------EEE--------HHHHHHHHH----EEEEEEEE------EEEEEEE--HHHHHHHHHHH-------EEEEEEE-----HHHHHHHH------------------HHHHHHHH------EEEEEEE--------EEEEE---HHHHHHHHHHH-------EEEEE------HHHHHHHHHHHHHH-----------EEEEE-------HHHHHHHH-----EEEEEEEE------EEEEEE---HHHHHHHHHHH---EE--EEEEEEEEE--HHHHHHHHHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHH---HHHHHHHHHHHHHHHHHH-----------------HHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHH---------- PABP-1_1 psipred -----------EEEE------HHHHHHHHHHH----EEEEEEE----------EEEEE---HHHHHHHHHHH---------EEEEEE-------------EEEE--------HHHHHHHHHH--EEEEEEEE-------EEEEE---HHHHHHHHHHHH-------EEEEE-----HHHHHHHHHHHHH---EEEE-------HHHHHHHHHH---EEEEEEEE--------EEEEE---HHHHHHHHHHH--------EEEEE----HHHHHHHHHHHHHHHHHHHHHH----EEEEE-------HHHHHHHH-----EEEEEEEE-------EEEEEE--HHHHHHHHHHHHHHH-----EEEEEHHHHHHHHHHHHHHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHH---HHHHHHHHHHHHHHHHHHH-HHH--HHHHHHHH--HHHHHHH---HHHHHHHHHHHHHHHHHHHH----------------- PABP-1_1 prof -----------EEEE--------HHHHHHHH-----EEEEEEE------------------HHHHHHHHHHH---------EEEE--------------EEEEE---------HHHHHHHHH----EEEEEE-------EEEEEE-HHHHHHHHHHHH---EE---EEEE-------------------EEEEEEE-----HHHHHHHHHH-----EEEEEEEE-----------E----HHHHHHHHHHH--------EEEEE---HHHHHHHHHHHHHHHHHHHHH-------EEE--------HHHHHHHH------EEEEEEE-----EEEEEEEE---HHHHHHHHHHHHHHHH---EEEEE---HHHHHHHHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHH---HHHHHHHHHHHHHHHHHHH------------------EEEEE----HHHHHHHHHHHHHHHHH------------------- PABP-1_1 jnet -----------EEEE--------HHHHHHHHHH---EEEEEEE----------EEEEEE--HHHHHHHHHHH--------EEEEEE-------------EEEEE---HH--HHHHHHHHHH---EEEEEEEE-------EEEEEE--HHHHHHHHHHH--------EEEEEEE------------------EEEE--------HHHHHHHHHH---EEEEEEEE--------EEEEEE--HHHHHHHHHHH--------EEEEEE----------------------------EEEEEE-------HHHHHHHHHH---EEEEEEE--------EEEEEE--HHHHHHHHHHH---E----EEEEEEE-------HHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH---HHHHHHHHHHHHHHHHHH--HHH------EEE----HHHHHHH--HHHHHHHHHHHHHHHHHHHH----------------H PABP-1_1 sable -----------EEEEE-------HHHHHHHHHHH-EEEEEEEEEEE-------EEEEEE--HHHHHHHHHHH-------EEEEEEE------------EEEEEE-------HHHHHHHHHHHEEEEEEEEE-E------EEEEEE--HHHHHHHHHHH--------EEEEEE-------------------EEEEE-------HHHHHHHHHHH-EEEEEEEEEE---EEE-EEEEEEE-HHHHHHHHHHH---------EEEEEE--------HHHEE---------------EEEEE-------HHHHHHHHHHH--EEEEEEE--------EEEEEEE-HHHHHHHHH---------EEEEEEEE--HHH-HHHH-HHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHH----HHHHHHHHH-----HHHHH---HHHHHHHHHHHHHHHHHHHH----------------- PABP-1_1 proteus -----------EEEE--------HHHHHHHH-----EEEEEEEE----------EEE----HHHHHHHHHHH---H-----EEEEE----HHHH-----EEEEE-------HHHHHHHHHH---EEEEEEEEE--------EE----HHHHHHHHHHH---------EEE-----HHHHHHHHHHHH----EEEEE-------HHHHHHHHHH----EEEEEEE----------EE----HHHHHHHHHHH--------EEEEEHH--HHHHHHHHHHHHHHHHHHHHHH------EE--------HHHHHHHH------EEEEEE----------EE----HHHHHHHHHHH---------HHHHHHH-HHHHHHHHHHHHHHHHHHHH----------------------------------------------------------------------------------------------------------HH----------------------------------------------HHHHHHH---HHHHHHHHHHHHHHHHHHH-HHHHHHHHHHH----HHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHH--------- PABP-1_1 sspro4 ----------EEEEE--------HHHHHHHHHHH--EEEEEEEE---------EEEEE---HHHHHHHHHHH--EEE--EEEEEE--------------EEEE--------HHHHHHHHHHH--EEEEEEEE------EEEEEEE--HHHHHHHHHHH--EEE--EEEEEE-----HHHHHHHH-------EEEE--------HHHHHHHHHHH--EEEEEEEE-------EEEEEE---HHHHHHHHHHH--EEE--EEEEEE----HHHHHHHHHHHHHHHH----------EEEE--------HHHHHHHHHH---EEEEEEE-------EEEEEEE--HHHHHHHHHHH--EEE--EEEEEEE---HHHHHHHHHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH---HHHHHHHHHHHHHHHHHHH---------HHHHH--HHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHH---------- PABP-1_1 psspred ----------EEEEE--------HHHHHHHHHHH----EEEEEE---------EEEEE---HHHHHHHHHHH-------EEEEEEE-------------EEEE--------HHHHHHHHHHH--E-EEEEEEE------EEEEE---HHHHHHHHHHHH--E----EEEE------HHHHHHHHHHHHH--EEEE--------HHHHHHHHHHH--E-EEEEEE--------EEEEE---HHHHHHHHHHH---EE--EEEEEE----HHHHHHHHHHHHHHHHHH-HH----EEEEE--------HHHHHHHHHHH--E-EEEEEE-------EEEEE---HHHHHHHHHHHH-EEE---EEEEEEEE-HHHHHHHHHHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHH---HHHHHHHHHHHHHHHHHHH--HH------HHHH--HHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHH--------- PABP-1_1 spineX ----------EEEEE--------HHHHHHHH-----EEEEEEE----------EEEEE---HHHHHHHHHH---------EEEEEE-------------EEEE--------HHHHHHHHH----EEEEEEEE-------EEEEEE--HHHHHHHHHHH---EE---EEEEEEE-----------------EEEEE--------HHHHHHHH-----EEEEEEEE--------EEEEEE--HHHHHHHHHHH---EE---EEEEE-----------------------------EEEEE--------HHHHHHH------EEEEEEEE-------EEEEEE--HHHHHHHHHH---EEE---EEEEEEE------------HHHHH-------------------------------------------------------------------------------------------------------------HHHHH----------------------------------------------HHHHHH-----HHHHH-----------------------H----HHHHHHHH--HHHHHHHHHHHHHHHHHHH------------------ PABP-1_1 raptorxss ----------EEEEEE-------HHHHHHHHH----EEEEEEEE---------EEEEE---HHHHHHHHHHH---EE---EEEEEE------------EEEEEE---HH--HHHHHHHHHH---EEEEEEEE-------EEEEEE--HHHHHHHHHHH---EE--EEEEEEE-E---H---------H-----EEE-------HHHHHHHHHH---EEEEEEEE-------EEEEEEE--HHHHHHHHHHH--EEE--EEEEEE------HHHHHHHHH--H------------EEEEE-------HHHHHHHHH----EEEEEEEE-------EEEEEE--HHHHHHHHHHH---EE--EEEEEEEE---HHHHHHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------HHHH------HHHHHHHHHHHHHHHHH-HH------HHHH----HHHHHHH--HHHHHHHHHHHHHHHHHHHH-HHH------------- PABP-1_1 SPARROW ------------EEEE-------HHHHHHHHH----EEEEEEEE---------EEEEEE--HHHHHHHHHHH---EE---EEEEEE--------------EEEE-------HHHHHHHHH----EEEEEEEE-----E-EEEEEE--HHHHHHHHHHH---EE---EEEEEE-------------------EEEE--------HHHHHHHHHHH--EEEEEEEE--------EEEEE---HHHHHHHHHHH---EE--EEEEEEE------HHHHHH----------------EEEEEE-------HHHHHHHHHH---EEEEEEEE-------EEEEE---HHHHHHHHHHH--EEE--EEEEEEEEE---HHHHH--HHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH---HHHHHHHHHHHHHHHHHHH--HH------------HHHHHHHH--HHHHHHHHHHHHHHHHHHHH-HHH------------- PABP-1_1 *SPARROW ---------EEEEEEEE------HHHHHHHHHHH--EEEEEEEE------EE--EEEEEE-HHHHHHHHHHH--EEE----EEEEEEE--HHHHH---EEEEEE-HHHHH-HHHHHHHHHHHEEEEEEEEEE------EEEEEEEEEHHHHHHHHHHE---EE---EEEE-----HHHHHHHHHHHHHHHHHEEEE-------HHHHHHHHHHH-EEEEEEEEE-----EE---EEEEE-HHHHHHHHHHH---EE---EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH---EEEEE---H---HHHHHHHHHHHEEEEEEEEEEH-------EEEEEE-HHHHHHHHHHH---EEEE---HHHHHHHHHHHHHHHHHHHHHHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHH-HHHHHHHHHHHHHHHHHHH-HHHH-EEE--EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------HH-HHH PABP-1_1 HMMSTR -----------EEEEE-------HHHHHHHHHHH--EEEEEEEE------EEEEEEEEE--HHHHHHHHHHH---EE--EE-EEEE-----HHHH----EEEEE-------HHHHHHHHH----EEEEEE----------EEEEE--HHHHHHHHHH----EE--EEEEEEE-------------------EEEEE-------HHHHHHHHH----EEEEEEEE-----EEEEEEEEE--HHHHHHHHHHH---EE--EEEEEEE-----------------------------EEEEE-------HHHHHHHH-----EEEEEEEE-----EEEEEEEE--HHHHHHHHHHH---E----EEEEEE----------HHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHH--------HHHHHHHHHHHHHHH-HHHHHHHHHHH----HHHHHHHHH-HHHHHHHHHHHHHHHHH-------------------- PABP-1_1 porter -----------EEEE--------HHHHHHHH------EEEEEEE---------EEEEEE--HHHHHHHHHHH---------EEEEE-------------EEEE--------HHHHHHHH------EEEEEEE-------EEEEEE--HHHHHHHHHHH---------EEEEE-------------------EEEE--------HHHHHHHH-----EEEEEEEE--------EEEEEE--HHHHHHHHHHH---------EEEEE-------HHHHHHHH-------------EEEEEE-------HHHHHHHH-----EEEEEEEE--------EEEEE--HHHHHHHHHHH---------EEEEE-------HHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHH-------------HHHHHHHHHHH--HHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHH--------- PABP-1_1 cdm -----------EEEEE-------HHHHHHHHHHH--EEEEEEEE------EEEEEEEEE--HHHHHHHHHH----EE--EE-EEEE-------------EEEEE-------HHHHHHHH-----EEEEEEE--------EEEEEE--HHHHHHHHHHH---EE--EE-EEEE-------------------EEEEE-------HHHHHHHHH----EEEEEEEE-----EEEEEEEEE--HHHHHHHHHHH---EE--EE-EEEE---------HHHHHH-------------EEEEEE-------HHHHHHHH-----EEEEEEEE--------EEEEE--HHHHHHHHHHH---------EEEEE-------HHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH---HHHHHHHHHHHHHHHHHHH----HHHHHHHH----HHHHHHHHH-HHHHHHHHHHHHHHHH--------------------- PABP-1_1 fdm -----------EEEEE-------HHHHHHHHHHH--EEEEEEEE------EEEEEEEEE--HHHHHHHHHH----EE--EE-EEEE-------------EEEEE-------HHHHHHHH-----EEEEEEE--------EEEEEE--HHHHHHHHHHH---EE--EE-EEEE-------------------EEEEE-------HHHHHHHHH----EEEEEEEE-----EEEEEEEEE--HHHHHHHHHHH---EE--EE-EEEE-----------------------------EEEEE-------HHHHHHHHH----EEEEEEE--------EEEEEE--HHHHHHHHHHH---EE--EE-EEEE------------HHHHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH---HHHHHHHHHHHHHHHHHHH----HHHHHHHH----HHHHHHHHH-HHHHHHHHHHHHHHHH--------------------- PABP-1_1 gor ----------EEEEEE-------HHHHHHHHH----EEEEEEEEE--------EEEEEE--HHHHHHHHHHH---EE---EEEEEE-------------EEEEE-------HHHHHHHHHH---EEEEEEEEE-----EEEEEEE--HHHHHHHHHHH--EEE---EEEEE------HHHHHHHHHH----EEEEE-------HHHHHHHHHH---EEEEEEEE------EEEEEEEE--HHHHHHHHHHH---EE---EEEEE------HHHHHHHHHHHHHHH-H-------EEEEE-------HHHHHHHH-----EEEEEEE-------EEEEEEE--HHHHHHHHHHH--EEE---EEEEEE----HHHHHHHHHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------HHHH----HHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHH--HHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHH--------- PABP-1_1 spine ------------EE--------HHHHHHHH-------EEEHHHHHHHHH----EEEE-----HHHHHHHHHH---------EEEEE--------------EEE---------HHHHHHHHH------EEEEE---------EEE---HHHHHHHHHHHHHHH-----EEEE----HHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHH------EEEE----------EEEE---HHHHHHHHHHH--------EEEEEHHHHHHHHHHHHHHHHHHHHH----------EEE--------HHHHHHHH--------HHHHHH-------EEEEE--HHHHHHHHHHH---EEE---HHHHHHHHHHHHHHHHHHHHHHHHHHHH------------------EEE-----------------------------------------------------------------------------------HHHHHHH------------------------------------------------------HHHHHHHHHHHHHHHHHH----------EEEE---HHHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------E PABP-1_1 nnssp -----------EEEEE-------HHHHHHHHHHH--EEEEEEEE------EEEEEEEEE--HHHHHHHH-------------EEEE-----HHHH----EEEEE-------HHHHHHHHHHH--EEEEEE----------EEEEE--HHHHHHH-----EEEE--EEEEEEE---HHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHH--EEEEEEEE---------EEEEE--HHHHHHHHHHH--------EEEE-HHHHHHHHHHHHHHHHHHHHHHHHHHH---EEEEE-------HHHHHHHH--------HHHHHH------EEEEEE--HHHHHHHHHHH--EEEEE--HHHHHHHHHHHHHHHHHHHHHHHHHHHH----------------------------------HHHHHHH---------------------------------------------------------------HHHHHH----------------------------------------------HHHHH---HHH---------HHHHHHH----HHHHHHHHHH--HHHHHHHHH-HHHHHHHHHHHHHHHHHH-HHHH-------------- PABP-1_1 pssfinder ------------EEE------HHHHHHHHH------EEEHHHHHHHH------EE-EE------HHHHHHHHHHHHH-----EEEEE-----HHH----EEEE---------HHHHHHHHH---EEE-EEEE---------EE----HHHHHHHHHHHH-------EEEEE-----HHHHHHHHHHHHHH-HHHHHH------HHHHHHHHHH---------HHHH--------EEEE--HHHHHHHHHHHH------EEEEEHHHHHHHHHHHHHHHHHHHHHHH---------HHHHH------HHHHHHHH----EE--HHHHHH------EEEEEE--HHHHHHHHHH----EEE---HHHHHHHHHHHHHHHHHHHHHHHHHH-------------------EEEE-----HHHHH-----HHHH------HHHH-----------------------------------EE--HHHH----------HHHHHHHHHHHHHH----------------------EEE---EEEE-----EEHHHH-----HHHHHHHHHHHHHHHHHH-HHHH-----EEEE---HHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------- PABP-1_1 sspal ------------EEEE------HHHHHHHHH-----EEEEEEEHHHHHHHHH-------HHHHHHHHHHH-----------EEEE----------------HHHHHHHHHHHHHHHHHHHHH--EEEEEEEE-------EEEEEHHHHHHHHHHHHHH--------EEEEHHHHHHHHHHHHHHHHHHHHHHEEEE-HHHHHHHHHHHHHH------EEEEEEE--------EEEHHHHHHHHHHHHHHHH--------EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEE------HHHHHHHHH--------------------EEEEEEE--HHHHHHHHHH------HHHHHHHHHHHHHHHHH---HHHHHHHHH--------------------------HHHHHHHHH---HHHHHH------------------------------------------------------------HHHHHHHHH----------------------------EEEE---EEEE----HHHHHHHHH--HHHHHHHHHHH--HHHHH---HHHHHHHHHHH---HHHHHHHHH-HHHHHHHHHHHHHHHH-HHHHHHHHH---------- PABP-1_1 ssp -----------EEEEE-------HHHHHHHHHH---EEEEEEE----------EEEEEE--HHHHHHHHHHH---------EEEE--------------EEEEE-------HHHHHHHHHH---EEEEEEEE------EEEEEEE--HHHHHHHHHHH--------EEEEEE------------------EEEEEE-------HHHHHHHHHH---EEEEEEEE-------EEEEEEE--HHHHHHHHHHH---------EEEE------------------------------EEEEE-------HHHHHHHHHH-----EEEE--------EEEEEEE--HHHHHHHHHH----------EEEEE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHH------HHHHHHHHHHHHHHHHH-----------------HHHHHHH--HHHHHHHHHHHHHHHHHHHH----------------- PABP-1_1 sspred -----------EEEEE-------HHHHHHHHHH---EEEEEEEE---------EEEEE---HHHHHHHHHHH--------EEEEEE-------------EEEE--------HHHHHHHHHH----EEEEEEE-------EEEEEE--HHHHHHHHHHH---EE---EEEEEE-------------------EEEEE-------HHHHHHHHHH---EEEEEEEE--------EEEEEE--HHHHHHHHHHH---EE---EEEEE--------HHHH------------------EEEE--------HHHHHHHHHH---EEEEEEEE-----EEEEEEE---HHHHHHHHHHH---EE--EEEEEEE------HHHH-HHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------HHHH----HHHHHHHHHHH---HHH------------------HHHHHHH---HHHHHHHHHHHHHHHHHHHH----------------- PABP-1_1 netsurfp -----------EEEE--------HHHHHHHHH----EEEEEE------------EEEE---HHHHHHHHHHH---E----EEEEE--------------EEEE--------HHHHHHHHH-----EEEEEEE--------EEEEE--HHHHHHHHHHH---EE---EEEE-E-------------------EEEE--------HHHHHHHHH----EEEEEEEE--------EEEEEE---HHHHHHHHHH---EE---EEEE---------HHHH-H-H-H------------EEEE--------HHHHHHHHH----EEEEEEE--------EEEEE----H-HHHHHHHH---EE---EEEEEE--------HHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH---HHHHHHHHHHHHHHHHHHH----------EE-----HHHHHHH--HHHHHHHHHHHHHHHHHHHHH--HHHH---------- PABP-1_1 soprano -----------EEEEE-------HHHHHHHHH----EEEEEEEE---------EEEEEE--HHHHHHHHHHH--------EEEEEE-------------EEEEE-------HHHHHHHHHH---EEEEEEEE-------EEEEEE--HHHHHHHHHHH---EE---EEEEEE-----H-------------EEEEE-------HHHHHHHHHH---EEEEEEEE--------EEEEEE--HHHHHHHHHHH---EE---EEEEE------HHHHHHHHHHHHH-----------EEEEE-------HHHHHHHH-----EEEEEEEE-------EEEEEE--HHHHHHHHHHH---EE---EEEEEE----HHHHHHHHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH---HHHHHHHHHHHHHHHHHHH---------HHH----HHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHH------------- PABP-1_1 consensus MFPNSILGRPPFTPNHQQHNNFFTLSPTVYSHQQLIDAQFNFQNADLSRAVSLQQLTYGNVSPIQTSASPLFRGRKRLSDEKNLPLDGKRQRFHSPHQEPTVVNQIVPLSGERRYSMPPLFHTHYVPDIVRCVPPFREIAFLEPREITLPEAKDKLSQQILELFETCQQQISDLKKKELCRTQLQREIQLLFPQSRLFLVGSSLNGFGTRSSDGDLCLVVKEEPCFFQVNQKTEARHILTLVHKHFCTRLSGYIERPQLIRAKVPIVKFRDKVSCVEFDLNVNNIVGIRNTFLLRTYAYLENRVRPLVLVIKKWASHHQINDASRGTLSSYSLVLMVLHYLQTLPEPILPSLQKIYPESFSPAIQLHLVHQAPCNVPPYLSKNESNLGDLLLGFLKYYATEFDWNSQMISVREAKAIPRPDGIEWRNKYICVEEPFDGTNTARAVHEKQKFDMIKDQFLKSWHRLKNKRDLNSILPVRAAVLKR PAPD4_1 sequence -----------------------------------HHHHHH-------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH----EEEEE---------------EEEEE-----------HHHHHHHHHHHHHHHHHH--------------EEEEEEEE----EEEEEEEE--HHHHHHHHHHHHHH----HHHHHHHHHHHHHH------------HHHHHHHHHHHHH--------------------------------------------HHHHHHHHHHHH---------EEEE-----EE-----------EEEE--------------HHHHHHHHHHHHHHHHHHH-----------HHHHH-- PAPD4_1 psipred -------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH----EEEEEE--------------EEEEE-----------HHHHHHHHHHHHHHHHHH----EEEEEEEE--EEEEEEE-----EEEEE----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHHH--------HHH------------------------------HHHHHHHHHHHHHHHHH------EEEEE----------------EEEEE--------------HHHHHHHHHHHHHHHHHHH----HHHH---HHHH--- PAPD4_1 prof ------------------------------------------------------------------------------------------E-----------EEE-----------------------------------------------HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHH-----EEEEEEEE---------EEEEEEE------------HHHHHHHHHHHHHHHH------EE-------EEEEEEE-----EEEEEEE--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------------HHHHHHHHHHHH-------------------------------------------HHHHHHHHHHHHHH--------EEEEEE----------------EEEEE--------------HHHHHHHHHHHHHHHHHHH----------HHHH---- PAPD4_1 jnet -------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHH----EEEEE-------------EEEEEEE------------HHHHHHHHHHHHHHHHH----EEEEEE----EEEEEEE-----EEEEEEE----HHHHHHHHHHHHH---HHHHHHHHHHHHHHH------------HHHHHHHHHHHHH---------HHH-------------------------------HHHHHHHHHHHHHHH------EEEEE----EE-----------EEEEE--------------HHHHHHHHHHHHHHHHHHH----HHHHH-HHHHHH-- PAPD4_1 sable ------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH---EEEEEE-HHH---------EEEEEEE----------HHHHHHHHHHHHHHHHHH----EEEEEEEE---EEEEEEEE----EEEEEEE---HHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHH---------E-HHHHHHHHHHHHH---------HHH--------------E------E---------HHHHHHHHHHHHHHHE----E-EEE------------------EEEEEE-------------HHHHHHHHHHHHHHHHHHH------------HHHH-- PAPD4_1 proteus ------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH----EEEEE-------------EEEEEEE----------HHHHHHHHHHHHHHHHHH----EEEEEEEE----EEEEEEE-----EEEEEE---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHH---------HHHHHHHH--------------------------HHHHHHHHHHHHHHHH------EEEE---EEEE-----------EEEE--------------HHHHHHHHHHHHHHHHHHHH---HHHHH--HHHHH-- PAPD4_1 psspred -------------------------------HHHHHHHHHH-----H------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH----EEEE--------------EEEEEEE----------HHHHHHHHHHHHHHHHHHH-----EE--------EEEEEEE----EEEEEEEE--HHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHH--------HHH-------------E-----------------HHHHHHHHHHHHHHHH------EEEE---EEEE----------EEEEE--------------HHHHHHHHHHHHHHHHHHHH---HHH---HHHHHHH- PAPD4_1 spineX -----H-----------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHH-----EEEEE---------------EEEEE------------HHHHHHHHHHHHHHHH-----EEEEEEEEEEEEEEEEE-----EEEE-----HHHHHHHHHHHHHHHHH---HHHHHHHHHHHHH------------HHHHHHHHHHHHH---------------------EEEEEEE----------------HHHHHHHHHHHHHH------EEEE------E-----------EEEEE----------E---HHHHHHHHHHHHHHHHHHH----HHH----------- PAPD4_1 raptorxss ------H----------------------------------------------------------------------------------E---------------------------------------------HHH------------HHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHH----EEEEEEEE----------EEEEEEE-----------HHHHHHHHHHHHHHHHH-------EEEEEE---EEEEEEE----EEEEEEE--HHHHHHHHHHHHHHHH----HHHHHHHHHHHHH------------HHHHHHHHHHHHH---------HHHH------------HH-----------------HHHHHHHHHHHHH-EE-----EEE----EEEE----------EEEEE--------------HHHHHHHHHHHHHHHHHHH----HHHH----HHHH-- PAPD4_1 SPARROW -----------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH----EEEEE---H---------EEEEEE-----------HHHHHHHHHHHHHHHHHH-------EEEEEEEEEEEEEEEE----EEEEEE----HHHHHHHHHHHHHHH---HHHHHHHHHHHHHH------------HHHHHHHHHHHHHH------------------------------------------HHHHHHHHHHHHHH--------EEE-----EE------------EE----------------HHHHHHHHHHHHHHHHHHH----HHHH---------- PAPD4_1 *SPARROW -------------------------------------------------------------------------------------HHHHHHEE--------------------------------------------------------HHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHH-----EEEEEE--------------EEEEEE-----HH--HHHHHHHHHHHHHHHHHHH----HHHEEE-------EEEE------EEEEEEE-EEEEEHHHHHHHHHHH---HHHHHHHHHHHHHHH-E-------EEHHHHHHHHHHHHHH--------HHHHHHHH------HEEHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHE-----EEEEE----EE--HHHH-----EEEEE--------------HHHHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHH PAPD4_1 HMMSTR ----------------------EE----E--HHHHHHHH-------HHHHHHHHHH----------------------------------EEEE------EEEEEE--------------------------------------------HHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH-----EEEE-------------EEEEEE-----------HHHHHHHHHHHHHHHHHH-----EEEEE--EEE--EEEEE---H---EEEEE---HHHHHHHHHHHHHHH--HHHHHHHHHHHHHHH----------E-HHHHHHHHHHHHHH-------------HH-------------------------HHHHHHHHHHHHHHHHH------EEEE------E-------------EEE--------------HHHHHHHHHHHHHHHHHHH----HHHH---HHHHH-- PAPD4_1 porter --------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHH----EEEEE----EEE-------EEEEE--------HHHHHHHHHHHHHHHHHHHHH-------HHHH------EEEE-------EEEEEE------HHHHHHHHH-------HHHHHHHHHHHHH--------------HHHHHHHHHH---------------------------------------------HHHHHHHHHHH----------EEEE-----------------EEEE-----------------HHHHHHHHHHHHHHHHH------------------ PAPD4_1 cdm --------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHH----EEEEE----EEE-------EEEEE--------HHHHHHHHHHHHHHHHHHHHH-------HHHH------EEEE-------EEEEEE------HHHHHHHHH-------HHHHHHHHHHHHH--------------HHHHHHHHHH---------------------------------------------HHHHHHHHHHH----------EEEE-----------------EEEE-----------------HHHHHHHHHHHHHHHHH------------------ PAPD4_1 fdm --HHH---EE---HHHHH----------------HHHHHHHHHHHHHHHEEEHH--------HHH-------------EEEEE---------HHHHHHHHHHH-HHHHHH-----HHHHHHHHH--------HHHHHHH--------------HHHHHHH------HHH----HHHHHHHHHHHHHHHH------EEEEE-HH------------EEEE-------------HHHHHHHHHHHHHHHHHHH---HHEEEE-----EEEEEE-----EEEEE-----HHHHHHHHHHHHH--HHHHHHHHHHHHHHHH------------HHHHHHHHHHHHHH-HHHHHHHHHHH-HHHHHHHHHHH-------------------HHHHHHHHH-HHHH------EEE-------EEHH-----HHEE-EEE------------HHHHHHHHHHHHHHHHHHHHHH-----HHH--------- PAPD4_1 gor ---------------HHHH------------HHHHHHHHH-------------------------------------------------EEEEE-----------EEE---------------------------HHH------------HHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH----EEEEEEEEE----------EEEEE------HHH---HHHHHHHHHHHHHHHHHH----EE-------EE-EEEEEE-----EEEEEE---HHHHHHHHHHHHHHH--HHHHHHHHHHHHHHH------------HHHHHHHHHHHHHH----------------------------------------HHHHHHHHHHHHHHHHH------EEEEEE---EEE----------EEEEE--------------HHHHHHHHHHHHHHHHHHHH---HHH----HHHHH-- PAPD4_1 spine ----------------------EEE---EE-HHHHHHHHH------HHHHHHHHHH----------------------------------EEE--------EEEEEE-------------------------------EEE---------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----EEEE---------------EEEEE----EEEEEE----HHHHHHHHHHHH-------------------EEEE----EEEEEE-----EEE----HHHHHHHHHH-----EEEEE------------------HHHHHHHHHHHHH---------------------HHHHH------------------HHHHHHHHHHHH----------EE------------------EEEE--------HHHHHHHHHHHHHHHHHHHHHHHHH-----------HHHHHHHH PAPD4_1 nnssp -------------------------------HHHHHHHHH------HHHHHHHHHHH-------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----EEEEE---------------EEEEE--------------HHHHHHHHHHHHHHH-------HHHHH----EEEE--EEEEEEEE--------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------------HHHHHHHHHHHHHH------HHHHHH------HHHHHHHHH----------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------------EEEEEE------HHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHH-- PAPD4_1 pssfinder ---------------------EEE-------HHHHHHHHH--------HHHHHHH----------------------------------EEEE-------EEEEEEE------------EEEE-----EEEEE----EE-------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----EEEE---------------EEEEE-----EEEE----HHHHHHHHHHH--------------EEE--EEEEEE--EEEEEEEE----EEE----EEEEEHHHHHH------EEEHHHH-----------------HHHHHHHHH-----------HHHH----------HHH------------------HHHHHHHHHHHH--------EEEE--------------EE--EEEEEE------HHHHHHH---HHHHHHHHHHHHHHHH---------HHHHHHHH- PAPD4_1 sspal ----EEEE-------------------EEEE-HHHHHHHHH--------------EEEE-----------------------------------------EEEEEEEE-----------EEEEEEE--EEEEE--HHHHHHHHH---HHHHHHHHHHHHHHHHH---HHHHHHHHH--HHHHHHHHHHHHHH----EEEE---------------EEEEEEE--EEEEE-HHHHHHHHHHHHHHEEE-------------------------EEEEEEE-----------HHHHHHHHHHHHHEEEEEEEE------------------EEEEEEEEE---------HHHHHHHHH-------EEEEEEE---------HHHHHHHHHHHHHHHHHH---------HHHHHHHHH-------------EEEE-------HHHHHHHHH---HHHHHHHHHHHHHHHH---HHHHHHHHHHHHHH PAPD4_1 ssp -------------------------------HHHHHHHHH---------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH---EEEEEEEEE----------EEEEEEE-----------HHHHHHHHHHHHHHHH------EEEEE------EEEEEEE----EEEEEEE------HHHHHHHHHHH----HHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHH-----------------------------------------HHHHHHHHHHHHHHHH-------EEEEE-----------------EEEE---------------HHHHHHHHHHHHHHHHHHH----------HHH---- PAPD4_1 sspred -----------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHH----EEEEE--------------EEEEE------------HHHHHHHHHHHHHHHHH-------------EE----EEEE----EEEEEEE----HHHHHHHHHHHHHH---HHHHHHHHHHHHHH------------HHHHHHHHHHHHHH---------HHH----------------------------HHHHHHHHHHHHHHHHH-------EEEEE---EE------------EEEE--------------HHHHHHHHHHHHHHHHHHHH-----------HHHH-- PAPD4_1 netsurfp -------------------------------HHHHHHH----------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHH----EEEEEEEEE---------EEEEEEE-----------HHHHHHHHHHHHHHHHH-----EEEEEE------EEEEEE----EEEEEEE----HHHHHHHHHHHHHH--HHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHH--------HHHHHHH----------E-----------------HHHHHHHHHHHHHHHHHH---EEEE----EEE----------EEEEE--------------HHHHHHHHHHHHHHHHHHHH---HHHHH---HHHH-- PAPD4_1 soprano ------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH----EEEEE--------------EEEEEE-----------HHHHHHHHHHHHHHHHH------EEEEE-----EEEEEE-----EEEEEEE---HHHHHHHHHHHHHHH--HHHHHHHHHHHHHHH------------HHHHHHHHHHHHH---------HHH-------------------------------HHHHHHHHHHHHHHH-------EEEE-----E-----------EEEEE--------------HHHHHHHHHHHHHHHHHHH----HHH----HHHHH-- PAPD4_1 consensus PPPYDMKAYYGRSVDFRDPFEKERYREWERKYREWYEKYYKGYAAGAQPRPSANRENFSPERFLPLNIRNSPFTRGRREDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQKVKSVTV RBBP6_2C sequence -------------------HHHHHHHHHHHHHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHH---------------HHHHH----------------------------------------------------------------------------HHHH---------------------------------HHHHH----------------------------------------------HHHH----------HHHHHH----------------HHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHH--------------------HHHHH---------------------------------------------------------------HHHHHHHHHH----HHHHH--------------------------------------HHHHHHHHHHHHHHHHHH--------------HHHHHHHHHHHHH-------HHHHHH----HHH------ RBBP6_2C psipred -----------------------------HHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_2C prof -------------------------E---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_2C jnet ----------------------HHHHHHHHHHHHHHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_2C sable --------------------HHHHHHHHHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHH--------------------------------------------- RBBP6_2C proteus -----------------------HHHHHHHHHHHHHHHH--------------------HHHH-----------------------------------------------------------------------EE------------HHH-------------------------------------------EEE--------------E----------------------------------------------------------------------------------------------------------------------------------------------------------------E--------------------------------EEE-----------------------------------------EEEE------------------------------------------------------EEEEEE-------------------------------------------------EEE----------------EE------------------------------HHH-------------HHHH--------------------------------------EEEE----------------------------------------------------------------------------------------------EEEE----------------------------------------------------------H-------------------EH---------HH---------------------------------------------------HH---HH------EE---------------------EEE------------------------------------ RBBP6_2C sspro4 ----------------------------HHHHHHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_2C psspred ---HHHHHH----------HHHHHHHHHHHHHHHHHHHHHHH---------------------------------------------------------------------------------------HHHHHHH----HHHHH---HHHHHHHH---------------H----------------------------HHHHHHHH-------HHH-------------------------HHHH----------HHHH-------------------------HHH--HHHHHH-----HHHHHH---H---HHHHHHHHHHHHHH----------HHHHHHHHHHHHHH-----HHHH-------HHHH----------HHHHHH----HH--------HHHHHHHHHH----------------HHH----HHHHHHHHHHHHHH------------------------------H--HHHHHHHHHHHHHH-------HHHHHHHH-----------HHHHHHHHH-----------------------------------HHHHHHH-----HHHHHHHHHHH-----------------HHHH--HHHH------HHHHHHHHHHHHH---------H-----H------------------------HHHHHHHHHHHHHHHHHHH----------HHH-----HHHH-----------------------------------HHHH---------HHHHHHHHHHHHH----------------HHHHHHHH---------------------------HHHHHH-------------HHHHHHHH------HHHHHHHHHHHHHHHHHHHHH-------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------- RBBP6_2C spineX ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ RBBP6_2C raptorxss -----------------------HHHHH-------HHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHH-----------------------------------------------------HH------HHH----------------------------------- RBBP6_2C SPARROW ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ RBBP6_2C *SPARROW -----HHHE------------HHHHHHHHHHHHHHHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E RBBP6_2C HMMSTR --------------------HHHHHHHHHHHHHHHHHHHHH-H--------------------------------------------------------------------------------HHHHHHHHHHHHHHHHH--------HHHHHHH---------------HHHH--------------------------HH--------------------------------H----------------------HH-----------------HHH----------------------------------------------------------HHHH-------------------------------------HH------------------------HHHHHHHH-----------------------------HHHHHHH---------------------------------------------HHH------------HHH-------------HHHHH-----------------------------------------H-----HHHHHH-------------------------HHH---HHHHH-----------HHHH-------------HHH-HHHH-----HHHH-----HH-------HHH--HHHHHHHHHHHHH-----HHHHH---------HHH------HHHHHH------------------------------------HHHHHHHHHH------HHHHHHH----HHHHHHHHHHHH----------HHHH-----HHH---HHHHHH-----------------HH--HHHHHHHHHHHHHHH-----HHH----HHHHHHH---------------------------H----------------------------------------HHHH-----------HHHHHH----------- RBBP6_2C porter ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ RBBP6_2C cdm --------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEEEE--HHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_2C fdm ----------------------------------------------------------------------------------EEEEEEEE----------EEE-------------------------------------------------------------------EEEEE--HHHHHH--------------------------------------EEEEEEEE------EEEE---HHHHHHHHHHH----EEE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEEE--HHHHHHHH--HHHHHH----HHHHHH-----HHHHHH--HHHHH--------------------------------------------------------------------------HHHHHHHHHH--EEEEEEE---HHHHH--HHHHHHHHHHHH-EEEEEEE---EE----EEHHHHHHH------HHH-HHHHHH-----EEEE----------HHH--EEEE----HHH------------EEEEE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_2C gor ----HHHHH----------HHHHH--HHHHHHHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHH-------HHHH---------------------------------------------------------------------------------------------------------HHH---------------------------------------------------------------------------HHHH-H--------------------------------------------------------------------------------------------------------------------------------------------------------------H-H----HHHH----------HHHHHH-----------------HHHH------------ RBBP6_2C spine ---------------------HHHHHHHHHHHHHHHHHHHH-------------------------------------------------------------------------------------------HHHHHH----------HHHHHHHH---------------EEEE------------------EEEE------------------------------------------------------------HHHHH-------------------------HHHHHHHHH--------HHHHHHH-------HHHHHHHHHH---------------HHHHHHHH-----------------EEEE-------------------------EEE------EEE---------------------HHHHH-------------EEEEE--------EEEEE---------------------HHHHHHHHHH----------EEEEEE----------HHHHHH---------------------------EE----------HHHHHHHHHHHHHHHHHHHH-----------------HHHHHH----------------------------------------------------------------------------HHHHHHH------------------------------------------------------------------------HHHHHHHHH---------EEEEE-----HHHHHHH----------------------------------------------EEEE---------HHHHHHHHHHHHHH-----EEEEEE--------------------------------------HHHHHHHHHHHHHHHHHHHHHHHH----EEE----HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE RBBP6_2C nnssp ------------------HHHHHHHHHHHHHHHHHHHH---------------------HHH--------------------------------------------------------------------------------------HHHHHHHHH-------------EEEEEE------------------------HHHHHHH-------------------------------------------------------------------------------------------------HHHHHHH------------HHHHHH-----------------------------------EEEEEEEEEE----------------------EEEEE--HHHEEEE-------------------HHHHHHHHHHHHHHHH---EEEEEEEEE--EEEEEE---------------------HHHHHHHHHH--------HHHEEEEEE-------------------------------EEEE-------------------HHHHHHHHHHHHHHHHHHHHHH----------------HHHHHHH----------------HHHHHHH---------------------------------------------------------------------------------------------------------------------------------------EEEEEE-------EEEEEE-----HHHHHHHH----------------------------------------------------------HHHHHHHHHHHHHHHHHHHEEEEEEE-----------------------------------HHHHHHHHHHHHHH----------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-- RBBP6_2C pssfinder --------------------HHHHHHHHHHHHHHHHHHHHHHHH---------------------------------EEE--------------------------------HHHHHH-------------HHHHHHH---------------------------------EEEEE----------------EEE---HHHHHHHHH-----------------------EEE-------EE-------------HHHHHH-----------------------------HHHHHHHH-----HHHHHHHHHH----HHHHHHHHHHH--------------HHHHH---------------EE----HHHHH--------------------------HHHHHHHHHHHHH------------------HHHHH--HHHHHHHH----EEEE--------EEE----------------------HHHHHHHHHHH----------EEEEEEE-EEE----HHHHHHHHHHH-----------------------EE----------HHHHHHH----HHHHHH------------------HHH-HHHHH-------------HHHHHHHH---------HHHHHHHH-----------------------------------HHHHHHHHH--------------------HHH---------------------------EEEE--------HHH--------HHHHHHHHH--------EEEEE-----------------------------------HHHHHHHH---------------EEE----------HHHHHHHHHHHHH------EEE-----------------------------------------HHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHH-------HHHHHHHHHH-HHHHEEEE RBBP6_2C sspal ----------------HHHHHHHHHHH--HHHHHHHHHH-------------------------------------------------------------------------------------------HHHHHHHHH---------HHHHH------------------EEEE------------------EEEEEEE-------------------------------------------------------HHHHHHHHH----------------EEEE----------------------------------HHHHHHHHHHHH------------HHHHHHHHHH------------EEEEEEE--------------------------EEEE----EEEE--------------------------------------EEEEEEE-------EEEE---------------------HHHHHHHHHHH----------EEEEEEE------------------------------------------EEEE--------HHHHHHHHH--HHHHHHHHH-------------------------------------HHHHHHHHHH------------------------------------------------HHHHHHHHH--------------------------------------------------------------------------HHHHHHHHH--------EEEEEEE--HHHHHHHHHEEEEE---------------------HHHHHHHHH-----------EEEE-----------HHHHHHHHHHH------EEEEEEE-------------------------------------------------------------------------------------HHHHHHHHH---------- RBBP6_2C ssp ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ RBBP6_2C sspred ---------------------------HHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_2C netsurfp -----H-HH------------HHHHHHHHHHHHHHHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_2C soprano ----------------------HHHHHHHHHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_2C consensus MSGDGATEQAAEYVPEKVKKAEKKLEENPYDLDAWSILIREAQNQPIDKARKTYERLVAQFPSSGRFWKLYIEAEIKAKNYDKVEKLFQRCLMKVLHIDLWKCYLSYVRETKGKLPSYKEKMAQAYDFALDKIGMEIMSYQIWVDYINFLKGVEAVGSYAENQRITAVRRVYQRGCVNPMINIEQLWRDYNKYEEGINIHLAKKMIEDRSRDYMNARRVAKEYETVMKGLDRNAPSVPPQNTPQEAQQVDMWKKYIQWEKSNPLRTEDQTLITKRVMFAYEQCLLVLGHHPDIWYEAAQYLEQSSKLLAEKGDMNNAKLFSDEAANIYERAISTLLKKNMLLYFAYADYEESRMKYEKVHSIYNRLLAIEDIDPTLVYIQYMKFARRAEGIKSGRMIFKKAREDTRTRHHVYVTAALMEYYCSKDKSVAFKIFELGLKKYGDIPEYVLAYIDYLSHLNEDNNTRVLFERVLTSGSLPPEKSGEIWARFLAFESNIGDLASILKVEKRRFTAFKEEYEGKETALLVDRYKFMDLYPCSASELKALGYKDVSRAKLAAIIPDPVVAPSIVPVLKDEVDRKPEYPKPDTQQMIPFQPRHLAPPGLHPVPGGVFPVPPAAVVLMKLLPPPICFQGPFVQVDELMEIFRRCKIPNTVEEAVRIITGGAPELAVEGNGPVESNAVLTKAVKRPNEDSDEDEEKGAVVPPVHDIYRARQQKRIR CSTF3_1 sequence ------HHHH---HHHHHHHHHHHHHH----HHHHHHHHHHHH---HHHHHHHHHHHHHH----HHHHHHHHHHHHHH--HHHHHHHHHHHHH----HHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHH-------HHHHHHHHHHHH-------HHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHH----HHHHHHHHHHHHHH--HHHHHHHHHHHH------HHHHHHHHHHHHHHH--HHHHHHHHHHHHH-----HHHHHHHHHHHHH----HHHHHHHHHHHHHH----HHHHHHHHHHHHH---HHHHHHHHHHHHH--------HHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHH----HHHHHH-----------------------------------------------------------HHHHHHHHH-------------HHHHHHHHH-------HHHHHHH-----------------------------------------------HHHHHHHHHH-- CSTF3_1 psipred ------HHHHH----HHHHHHHHHHHH----HHHHHHHHHHHHH--HHHHHHHHHHHHHH----HHHHHHHHHHHHH---HHHHHHHHHHHHHH---HHHHHHHHHHHHHH------HHHHHHHHHHHHHHHH------HHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------------HHHHHHHHHHHHHHHH--------HHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHH------------HHH---HHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHH-HHHHHHHHHHHHH------HHHHHHHHHHHHH---HHHHHHHHHHHHH-----HHHHHHHHHHHHH-----HHHHHHHHHHHH-----HHHHHHHHHHHHHHHH---HHHHHHHHHHHHHH-------HHHHHHHHHHHHH------HHHHHHHHHH------------------------------------------------------------------HHHHHHHHH-------------HHHHHHHHHH-----------------------------------------------------------HHHHHHHHHHH-- CSTF3_1 prof ---------------HHHHHHHHHHHH----HHHHHHHHHHH----HHHHHHHHHHHHH-----HHHHHHHHHHHH----HHHHHHHHHHHHH-----HHHHHHHHHHHH-------HHHHHHHHHHHHHH---------HHHHHHHHHHH--------HHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHH----------------HHHHHHHHHHHHHHHHH--------HHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHH------------------HHHHHHHHHHHHH-----HHHHHHHHHHHH----HHHHHHHHHHHHH------HHHHHHHHHHHHHH----HHHHHHHHHH------HHHHHHHHHHHHH------HHHHHHHHHHH-----HHHHHHHHHHH-------HHHHHHHHHHH-------HHHHHHHHHHHHHH----HHHHHHHHHHHHH--------HHHHHHHHHHH-------------------------------------------------------------------------------------HHHHHHH--------------HHHHHHHH--------------------------------------------------------------HHHHHHHHH--- CSTF3_1 jnet -------HHHHH--HHHHHHHHHHHHH----HHHHHHHHHHHH---HHHHHHHHHHHHHH----HHHHHHHHHHHHH---HHHHHHHHHHHHHH---HHHHHHHHHHHHHH------HHHHHHHHHHHHHHH-------HHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------------HHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHH--HHHHHH--HHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHH---HHHHHHHHHHHHH-----HHHHHHHHHHHHHHH--HHHHHHHHHHHHH-----HHHHHHHHHHHHHH---HHHHHHHHHHHHHH----HHHHHHHHHHHHH---HHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHH-----HHHHHHHHHHHHH-------HHHHHHHH--------------------------------------------------------------------HHHHHHHHH-------------HHHHHHHHH------------------------------------------------------------HHHHHHHHHHHHH CSTF3_1 sable -------HHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHH--HHHHHHHHHHHHHH----HHHHHHHHHHHHHH--HHHHHHHHHHHHHH---HHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHH------HHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHH--------HHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHH---HHHHHHHHHHHHH-----HHHHHHHHHHHHHHH--HHHHHHHHHHHHH------HHHHHHHHH-------HHHHHHHHHHHHHH----HHHHHHHHHHHHHH--HHHHHHHHHHHH------HHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHH--------HHHHHHHH----------HHHHHHH-----HHHHHH----------------------------------------------------------HHHHHHHHH-------------HHHHHHHHH------------------------------------------------------------HHHHHHHH----- CSTF3_1 proteus ------HHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHH---HHHHHHHHHHHHHH----HHHHHHHHHHHHH---HHHHHHHHHHHHHH---HHHHHHHHHHHHHH-------HHHHHHHHHHHHHH------HHHHHHHHHHHHHH-H----HHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHH--------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHH-------HHHHHHHHHHHHHHH--HHHHHHHHH--------HHHHHHHHHHHHHH----HHHHHHHHHHHHHH----HHHHHHHHHHHHH---HHHHHHHHHHHHH------HHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHH--HH-----HEEEE-H--H-------HHHHHHH------HHHHH----------------------------------------------------------HHHHHHHHH-------------HHHHHHHHHH--------HHHHH-------H------------E--------------H---------HHHHHHHHHHHH-- CSTF3_1 sspro4 -------HHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHH--HHHHHHHHHHHHHH----HHHHHHHHHHHHHH--HHHHHHHHHHHHHH---HHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHH--HHHHHHHHHHHH--HHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHH--HHHHHHHHHHHHHH---HHHHHHHHHHHHHHHH--HHHHHHHHHHHHHH----HHHHHHHHHHHHHH---HHHHHHHHHHHHHH---HHHHHHHHHHHHHHH--HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHH---HHHHHHHHHHHHH-------HHHHHHHHHHH-HHHHHHH---------------------------------------------------------HHHHHHHHH-------------HHHHHHHHHH-------------------------------------------------------------HHHHHHHHH-- CSTF3_1 psspred ------HHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHH--HHHHHHHHHHHHHH----HHHHHHHHHHHHHH--HHHHHHHHHHHHHH---HHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------HHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHH-HHHHHHHHHHHHHH---HHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHH---HHHHHHHHHHHHHH--HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHH----------------------------------------------------------HHHHHHHHHH-------------HHHHHHHHHH------HHHHHHHHH------H------------------------------------HHHHHHHHHHHH-- CSTF3_1 spineX ------H------HHHHHHHHHHHHHH----HHHHHHHHHHHH---HHHHHHHHHHHHHH----HHHHHHHHHHHHH---HHHHHHHHHHHHHH---HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHH---------HHHHHHHHHHHHH-----HHHHHHHHH------HHHHHHHHHHHHH-----------------HHHHHHHHHHHHHHH--------HHHHHHHHHHHHHHHHHH----HHHHHHHHHH------EEEEEEEEEE----HHHHHHHHHHHHH------HHHHHHHHH-------HHHHHHHHHHHHHH----HHHHHHHHHHHHHH---HHHHHHHHHHHHHH---HHHHHHHHHHHHHHH---HHHHHHHHHHHHHH----HHHHHHHHHHHHH---HHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHH---HHHHHHHHHHHHH--------EEEEEEE------------HHHHHH--------EE---E--------------------------------------------------------HHHHHHHH--------------HHHHHHHHHH-------HHHH------------------------------------------------H-HHHHHHH---- CSTF3_1 raptorxss ------HHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHH--HHHHHHHHHHHHHH----HHHHHHHHHHHHH---HHHHHHHHHHHHHH---HHHHHHHHHHHHHH------HHHHHHHHHHHHHHH-------HHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------------HHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHH-HHHHHHHHHHH----HHHHHHHHHHHHHHH--H-HHHHHHHHHHHHH---HHHHHHHHHHHHHHH---HHHHHHHHHHHHHHH--HHHHHHHHHHHH-----HHHHHHHHHHHHHHH---HHHHHHHHHHHHHH----HHHHHHHHHHHHH---HHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHH------HHHHHHHHHHHHH-------HHHHHH--HH---HH--------------------------------------HHHHHH-----------------HHHHHHHH------H-------HHHHHHHHHH----------------------------------------------------------HHHHHHHH------ CSTF3_1 SPARROW ------HHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHH---HHHHHHHHHHHHHH----HHHHHHHHHHHHHH--HHHHHHHHHHHHHH---HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHH--------HHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--HH------HHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHH--HHHHHHHHHHH---HHHHHHHHHHHHHHH----HHHHHHHHHHHHHH--HHHHHHHHHHHHH-----HHHHHHHHHHHHHHH--HHHHHHHHHHHHH-----HHHHHHHHHHHHHH---HHHHHHHHHHHHHH----HHHHHHHHHHHHHH--HHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHH----HHHHHHHHHH--HHHHHHH-----------------------H-----HH---HH--HH----------------HHHHHHHHHH---HHH-------HHHHHHHHH------------------------------------------------------------HHHHHHHHHH--- CSTF3_1 *SPARROW ------HHHHHHHHHHHHHHHHHHHHH-HH-HHHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHH-HHHHHHHHHHHHHHHHH----HEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------------HHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--HHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHH-HHHHHHHHHHHHHH----EEEEHHHHHHHHHHH--HHHHHHHHHHHHHH----HHHHHHHHHHHHHHH-HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHH---------------------------------H------------------------HHHHHHHHHH-----EE----E-HHHHHHHHHH----------------------------------------------------------HHHHHHHHHHHHHH CSTF3_1 HMMSTR ------HHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHH---HHHHHHHHHHHH------HHHHHHHHHHHHH---HHHHHHHHHHH------HHHHHHHHHHHHHH------HHHHHHHHHHHHHHH-------HHHHHHHHHHHHH--------HHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHH-HHHHHHHHH--HHHHHHHHHHHHHHHHHHHH-------------HHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHH---HHHHHHHHHHHH------HHHHHHHHHHHHHHHH-HHHHHHHHHHHH-------HHHHHHHHHHHHH---HHHHHHHHHHHHHHH---HHHHHHHHHHHH----HHHHHHHHHHHHH-----HHH-HHHHHHHHHHHHHH--HHHHHHHHHHHHHH-HHH----HHHHHHHH--E--E----HHHHH--------HHHHH----------------------------------------------------------HHHHHHHHH-------------HHHHHHHHHH----------HEEE-------E------------------------------------HHHHHHHHHHH--- CSTF3_1 porter -------HHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHH---HHHHHHHHHHHHHH----HHHHHHHHHHHHH---HHHHHHHHHHHHHH---HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHH-HHHH--HHHHHHHHHHHHHHHHH----HH-HHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHH---HHHHHHHHHHHHHHH--HHHHHHHHHHHHH-----HHHHHHHHHHHHHHH--HHHHHHHHHHHHHH---HHHHHHHHHHHHHHH---HHHHHHHHHHHHHH----HHHHHHHHHHHHH---HHHHHHHHHHHHH-------HHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHH-----HH-H------------------------------------------------------------HHHHHHHHH-------------HHHHHHHHH-------HHHHHHHH--------E------EEEE---------------HHH-------HHHHHHHHHH---- CSTF3_1 spine -----HHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHH---HHHHHHHHHHHHHH-----HHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHH-----HHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHHHHH---------HHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHH---EEE----HHHHHHHHHHHHHHHHHHHHH------EEEHHHHHHHHHHH----HHHHHHHHHH------EEEEHHHHHHHH-----HHHHHHHHHHHHH-----HHHHHHHHHHHHH-----HHHHHHHHHH------HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHH----HHHHHHHH---------HHHHHHH----HHHHHHHHH---------HHHHHH------------------------------------------HHHHHHHH----EEE-----HHHHHHHHHHH------HHHHHHHH------EEE--------HHHHHHHHH-------------------HHHHHHHHHHHHH CSTF3_1 nnssp -----HHHHHHHH-HHHHHHHHHHHHH----HHHHHHHHHHH----HHHHHHHHHHHHHH----HHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------HHHHHHH---------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------------HHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHH---HHHHHHHHHHHHH------EEEEEEEE-----------HHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHH-----HHHHHHHHH--------------------------------------------------------HHHHHHHHH-------------HHHHHHHHHH------HHHHHHHHH----EEEEE-------HHHHHHHHH------------------HHHHHHHHHHHH-- CSTF3_1 pssfinder -------HHHHHHHHHHHHHHHHHHH------HHHHHHHHHH----HHHHHHHHHHHHHH------HHHHHHHHHHHHH-HHHHHHHHHHHHHHHH----HHHHHHHHHHH------HHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHH---------HHHHHHHHHHHHH---HHHHHHHHHHH------HHHHHHHHHHHHHHHH------------HHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHH--HHHH----HHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHH----HHHHHHHHHHH-----HHHHHHHHHHHH-----HHHHHHHHHHHHH-----HHHHHHHHHHHHH-----HHHHHHHHHH------HHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHH----HHHHH----EEE-----HHHHHHH------HHHHHEEE------HHHH--HHHH--------------HHH-----------------------HHHHHHH-----------EE-HHHHHHHHHH------HHHHHHHH------EE--------HHHHHHHHH---------------------HHHHHHHHHHHH CSTF3_1 sspal -------HHHHHHHHHHHHHHHHH-------HHHHHHHHHHHH---HHHHHHHHHHHHHH------EEEEEEEHHHHH---HHHHHHHHHEEEEEEEE----EEEEEEE-----HHHHHHHHHHHHHHHHH---EEEEEEEEEEHHHHHHH---------HHHHHHHHHHHHHH-----HHHHHHHHH-----HHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHH---------------HHHHHHHHHHH--------------HHHHHHHHHHHHHHEEEEEEHHHHHHHHHHHHHHH--HHHHH------HHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHH---HHHHHHHHH-------HHHHHHHHHHHH-----HHHHHHHHH---EEEEEEEEHHHHHH-------EEEEEEEHHHHHH--HHHHHHHHHHHHHHH-------EEEEEEEE----------HHHHHHHHH---HHHHHHHHH-HHHHHHHHHHHH---HHHHHHHHHHHHHH------HHHHH----HHHHHHHHHH--------------------------------------------------------HHHHHHHHH---------EEEHHHHHHHHHH------HHHHHHHHH-----------------HHHHHHHHH------------EEEE-HHHHHHHHHH---- CSTF3_1 ssp -------HHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHH--HHHHHHHHHHHHHH----HHHHHHHHHHHHHH--HHHHHHHHHHHHHH---HHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHH-HHHHHHHHHHHHHH----HHHHHHHHHHHHHH---HHHHHHHHHHHHHH----HHHHHHHHHHHHHH--HHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHH--HHHHHHHHHHHHHH--HHHHHHHHHHHHHHHH--------HHHHHHH------HHH-------------------------------------------------------------HHHHHH---------------HHHHHHHHH-------HHHHHHH----------------------------------------------HHHHHHHH----- CSTF3_1 sspred ------HHH----HHHHHHHHHHHHHH----HHHHHHHHHHHH---HHHHHHHHHHHHHH----HHHHHHHHHHHHH---HHHHHHHHHHHHHH---HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------------HHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHH---HHHHHHHHHHH---HHHHHHHHHHHHHH-----HHHHHHHHHHHHH---HHHHHHHHHHHHHH----HHHHHHHHHHHHHHH--HHHHHHHHHHHHHH----HHHHHHHHHHHHHH---HHHHHHHHHHHHHH----HHHHHHHHHHHHH---HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHH------HHHHHHHHHHHHH-------HHHHHHHHHH--HHH--------------------------------------HHHHH------------------HHHHHHHH--------------HHHHHHHHHH------------------------------------------------------------HHHHHHHHHH-- CSTF3_1 netsurfp --------HHH---HHHHHHHHHHHHH----HHHHHHHHHHHHH--HHHHHHHHHHHHHH----HHHHHHHHHHHHHH--HHHHHHHHHHHHHH---HHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHH------HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHH----HHHHHHHHHHH--HHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHH---HHHHHHHHHHHHHH----HHHHHHHHHHHHHHH--HHHHHHHHHHHHH-----HHHHHHHHHHHHHH---HHHHHHHHHHHHHH----HHHHHHHHHHHHHH--HHHHHHHHHHHHHH----HH-HHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHH----HHHHHHHHHHH----------------------------------------------H------------------HHHHHHHHH-------------HHHHHHHHHH------------------------------------------------------------HHHHHHHHHH-- CSTF3_1 soprano ------HHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHH---HHHHHHHHHHHHHH----HHHHHHHHHHHHHH--HHHHHHHHHHHHHH---HHHHHHHHHHHHHH------HHHHHHHHHHHHHHH-------HHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHH--HHHHHH-HHHHHHHHHHHHHHH----HHHHHHHHHHHHHH--HHHHHHHHHHHHHH----HHHHHHHHHHHHHHH--HHHHHHHHHHHHH-----HHHHHHHHHHHHHH---HHHHHHHHHHHHHH----HHHHHHHHHHHHH---HHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHH---HHHHHHHHHHHHH-------HHHHHHH-----HHHHH-----------------------------------------------------------HHHHHHHHH-------------HHHHHHHHHH----------H------------------------------------------------HHHHHHHHHHH-- CSTF3_1 consensus MKLTDSVLRSFRVAKVFRENSDKINCFDFSPNGETVISSSDDDSIVLYDCQEGKPKRTLYSKKYGVDLIRYTHAANTVVYSSNKIDDTIRYLSLHDNKYIRYFPGHSKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLMHLQGKPVCSFDPEGLIFAAGVNSEMVKLYDLRSFDKGPFATFKMQYDRTCEWTGLKFSNDGKLILISTNGSFIRLIDAFKGVVMHTFGGYANSKAVTLEASFTPDSQFIMIGSEDGKIHVWNGESGIKVAVLDGKHTGPITCLQFNPKFMTFASACSNMAFWLPTIDD WDR82_1 sequence ----------EEEEEEE------EEEEEE-----EEEEE----EEEEEE----EEEEE-------EEEEEE-----EEEEE------EEEEEE----EEEEEE------EEEEEE-----EEEEE-----EEEEE-----EEEEEEE--EEEEEE-----EEEEEE----EEEEE---------EEEEE-------EEEEEE-----EEEEEE---EEEEEE----EEEEEEE--------EEEEEE-----EEEEE-----EEEEE-----EEEE--------EEEEEE-----EEEEE----EEE------ WDR82_1 psipred ------------EEEEEE----EEEEEEE-----EEEE-----EEEEEE-----EEEEEE----EEEEEEE-----EEEEE------EEEEEE-----EEEEE-----EEEEEEE-----EEEE-----EEEEEEE----EEEEEE---EEEEEE----EEEEE-----EEEEEE--------HHHHHHH-----EEEEEEE----EEEEE-----EEEEEE-----EEEEEEE------EEEEEEE----EEEEE-----EEEEEE-----EEEEE------EEEEEEE-----EEEE-----EEEEEE--- WDR82_1 prof -----------EEEEEEE-----EEEEEE-----EEEEE----EEEEEE-----EEEEEE-----EEEEEE-----EEEEEE-----EEEEEE-----EEEEEE-----EEEEEE-----EEEE-----EEEEEEE----EEEEE----EEEEEE-----EEEE-----EEEEE-------HHHHHH---------EEEEEE-----EEEEE----EEEEEE-----EEEEEEE-----EEEEEEEE-----EEEEE----EEEEEE-----EEEEEE------EEEEEE-----EEEEE----EEEEE---- WDR82_1 jnet -EE---------EEEEE------EEEEEE-----EEEEE----EEEEEE-----EEEEE------EEEEEE-----EEEEE------EEEEEE-----EEEEE------EEEEEE-----EEEE------EEEEE------EEEE-----EEEEE-----EEEEE----EEEEEE----------E----------EEEEEE-----EEEEE----EEEEEE-----EEEEE--------EEEEEEE-----EEEE-----EEEEEE-----EEEEE-------EEEEEE-----EEEE----EEEEEE---- WDR82_1 sable -EEE-------EEEEEEE----EEEEEEEE---EEEEEEE---EEEEEEE---EEEEEEE----EEEEEEE----EEEEEEE-----EEEEEE-----EEEEEE---EEEEEEEE----EEEEEEEE--EEEEEEE---EEEEEEE----EEEEEE---EEEEEEE---EEEEEE--------EEEEEE------EEEEEEEE---EEEEEEE---EEEEEE------EEEEE-------EEEEEEEE---EEEEEEE---EEEEEEE---EEEEEEE----EEEEEEEE----EEEEEE----EEEEEE--- WDR82_1 proteus ---E-HE-----EEEEE------EEEEEE-----EEEE-----EEEEEE-----EEEEE------EEEEEE-----EEEEEE-----EEEEEE-----EEEEE------EEEEEE-----EEEE-----EEEEEE-----EEEEE----EEEEEE-----EEEE-----EEEEEE--------HHHHHHH------EEEEEE-----EEEE-----EEEEEE-----EEEEE--------EEEEEEE-----EEEE-----EEEEEE-----EEEEEE------EEEEEE-----EEEE-----EEEEEE--- WDR82_1 sspro4 -EE--------EEEEEE------EEEEEE-----EEEEEE---EEEEEE-----EEEEEE-----EEEEEE-----EEEEEE-----EEEEEE-----EEEEE------EEEEEE-----EEEEEE---EEEEEE-----EEEEEE---EEEEEE-----EEEEEE---EEEEEE----------EEE--------EEEEEE-----EEEEEE---EEEEEE-----EEEEEE-------EEEEEEE-----EEEEEE---EEEEEE----EEEEEE-------EEEEEE-----EEEEEE---EEEEEE--- WDR82_1 psspred EEEE--------E-EEE------E-EEEEE----EEEEE----EEEEEE-----E-EE-------E-EEEEE----EEEEEE-----EEEEEE----EE-EEE------E-EEEEE----EEEEE----EEEEEE-----E--EEE---EEEEEEE----EEEEEE---EEEEEE--------EEEEEE------EE-EEEEE---EEEEEEE---EEEEEE----EE-EEEE-------EE-EEEEE----EEEEE----EEEEEE-----E-EE--------E-EEEEE----EEEEEE---EEEE----- WDR82_1 spineX -EE--------EEEEEE------EEEEEE-----EEEE-----EEEEE-------EEE---------EEEE-----EEEE-------EEEEE------EEEE-------EEEEEE-----EEE------EEEEE------EEEEE------EEEE-----EEEE-----EEEEE----------H-HHE-------EEEEEE-----EEEE-----EEEEE------EEEEE---------EEEEEE-----EEEE-----EEEEE-----EEEEEE-------EEEEEE-----EEE------EEE------ WDR82_1 raptorxss -EE--------EEEEEEE-----EEEEEE-----EEEEEE---EEEEEE----EEEEEEE-----EEEEEE-----EEEEEE-----EEEEEE-----EEEEE------EEEEEE-----EEEEEE----EEEEE-----EEEE-----EEEEEE-----EEEEEE----EEEEE-------------E-------EEEEEE-----EEEEEE---EEEEEE----EEEEEEE-------EEEEEEE-----EEEEEE---EEEEEE-----EEE---------EEEEEE-----EEEEEE---EEEEE---- WDR82_1 SPARROW ------------EEEE-------EEEEEE------EE--HHE------E-----EEEE-------EEEEEE-----EEE--------EEE--E-----EEEE-------EEEEEE--E--EEE--E-E---E--E----EEEEEE----EEEEEE------EE--E--------E---------------------EEEEEE------E---E-E---E--E-----EEE--E--------EEEEEE------E---H----EE--E----EEE----------EEEEEE-----EEE--E---------EE- WDR82_1 *SPARROW EEEEE----H--HHHHHH----EEEEEEE-----EEEE-----EEEEE------EEEEEE----EEEEEEE-----EEEE-------EEEEE------EEEEEE----EEEEEEE-----EEEE-----EEEEE------EEEE----EEEEEEE-----EEEE-----EEEEE------EEHHHHHHHHH----EEEEEEE-----EEEE-----EEEEE------EEEEEE-------EEEEEEE-----EEEE-----EEEEE------EEEE-------EEEEEEE-----EEEE-----EEEEEE-HH WDR82_1 HMMSTR -EEEEHHH---EEEEEE------EEEEEE-----EEEEEE---EEEEEE-----EEEEEE-----EEEEEE-----EEEEEEE----EEEEEE-----EEEEE------EEEEEE-----EEEEEE----EEEEE-----EEEEE-----EEEEE-----EEEEEE----EEEEE--------EEEEEE-------EEEEEE-----EEEEEE---EEEEEE-----EEEEEE--------EEEEEE-----EEEEEE----EEEEE-----EEEEE-------EEEEEE-----EEEEE---EEEEEEE--- WDR82_1 porter HHHHHHHHHHHHHHHHHH-----EEEEEE-----EEEE-----EEEEEE---------EE-------EEEE-----EEEE--------EEEEE-----EEEE-------EEEEE-------EE-------EEEE---------EEE-------------EEEE-------EEEE----------EEEEE------EE----------EEEEE----EEE-------EEEE---------EEEEE--------EEEEE-----EEEE-----EEEEEE-------EEEEE---------------EEEE----- WDR82_1 nnssp ----HHHHHHHHHHHHHHH---EEEEEEE-----EEEEEE---EEEEEE------------------EEEEE----EEEEE---HHHHHHHHHH----EEEEE-----EEEEEEE--------------EEEEEE-----------------------EEEEE----HHHHHHHHH-------------------------------EEEEE--HHHHHHHHHH--EEEEE--------EEEEEEEE-----EEEEEE---EEEEEE-----EEEEE-------EEEEEE-HHH------------------- WDR82_1 pssfinder HHHHHHHHHHHHH------------EEEE-----EEEEE----EEEEEE-------EEEE-------EEEE-----EEEEE-------EEEEEE----EEEE------EEEEEEE-----EEEEE----EEEEEE-------EEEE-----EE------EEEEEE-----EEEE----------EEEEEE----EEE-EEEE-----EEEEE----EEEE------EEEEE---------EEEEEEE-----EEEEE----EEEEEE-----EEEEEE------EEEEE----EEEEE------EEEE----- WDR82_1 sspal ---------HHHHHHHHHH---------------EEEE------EEEE----------------------------EEEE-------EEEEEEEE--------------EEEEEEE----EEEE----HHHHHHHHH--------------EEEE----------HHHHHHHHH---------EEEEEEEE---------------EEEEEEE---HHHHHHHHHEEEEEEE--------EEEEEEEE---EEEEE------EEEE-----EEEEEEE------EEEEEEE---------------------- WDR82_1 ssp -E---------EEEEE------EEEEEEEE----EEEEEE---EEEEEE-----EEEEEEE---EE-EEEEE----EEEEEE-----EEEEEE-----EEEEE-----EEEEEEEEE----EEEE----EEEEEEE---EEEEEEEE--EEEEEEE----EEEEEE---EEEEEEE------EEEE---------EEEEEEEE----EEEEEE---EEEEEE-----EEEEEEEE-----EEEEEEEE----EEEEEE----EEEEE----EEEEEEE-----EEEEEEEE----EEEEE---EEEEEE---- WDR82_1 sspred --E---------EEEEE------EEEEEE-----EEEEE----EEEEEE-----EEEEEE-----EEEEEE-----EEEEE------EEEEEE-----EEEEE------EEEEEE-----EEEE-----EEEEEE------EEEE-----EEEEE----EEEEEE----EEEEEE----------EEEE-------EEEEEE----EEEEEE----EEEEEE-----EEEEEEE------EEEEEEEE---EEEEEE----EEEEEE-----EEEE--------EEEEEE-----EEEEE----EEEE----- WDR82_1 soprano -EE--------EEEEEE------EEEEEE-----EEEEE----EEEEEE-----EEEEEE-----EEEEEE-----EEEEE------EEEEEE-----EEEEE------EEEEEE-----EEEE-----EEEEEE-----EEEEE----EEEEEE-----EEEEE----EEEEEE---------EEEEE-------EEEEEE-----EEEEE----EEEEEE-----EEEEEE-------EEEEEEE-----EEEEE----EEEEEE-----EEEEE-------EEEEEE-----EEEE-----EEEEE---- WDR82_1 consensus MGEEANDDKKPTTKFELERETELRFEVEASQSVQLELLTGMAEIFGTELTRNKKFTFDAGAKVAVFTWHGCSVQLSGRTEVAYVSKDTPMLLYLNTHTALEQMRRQAEKEEERGPRVMVVGPTDVGKSTVCRLLLNYAVRLGRRPTYVELDVGQGSVSIPGTMGALYIERPADVEEGFSIQAPLVYHFGSTTPGTNIKLYNKITSRLADVFNQRCEVNRRASVSGCVINTCGWVKGSGYQALVHAASAFEVDVVVVLDQERLYNELKRDLPHFVRTVLLPKSGGVVERSKDFRRECRDERIREYFYGFRGCFYPHAFNVKFSDVKIYKVGAPTIPDSCLPLGMSQEDNQLKLVPVTPGRDMVHHLLSVSTAEGTEENLSETSVAGFIVVTSVDLEHQVFTVLSPAPRPLPKNFLLIMDIRFMDLK CLP1_1 sequence ------------EEEEE----EEEEEEE---EEEEEEEEEEEEEEEEEE----EEEE----EEEEEEE---EEEEE---EEEEEE-----EEE--HHHHHHHHHHHHHHH-----EEEEE------HHHHHHHHHHHHHH-----EEEEE-----------EEEEEEE---------------EEEEE--------HHHHHHHHHHHHHHHHHHHHH--------EEEE--------HHHHHHHHHHH----EEEEE---HHHHHHHHH----EEEEE------EEE--HHHHHHHHHHHHHHHH---------EEEEEE---EEEEEE--------------------EEEEE----------EEEEE-------------EEEEEEEEEEE----EEEEE----------EEEEEE---EE-- CLP1_1 psipred -------------EEEE----EEEEEE----EEEEEEE--EEEEE-EE-----EEEE----EEEEEEE---EEEEE----EEEE-----HHHHHHHHHHHHHHHHHHHH------EEEEE------HHHHHHHHHHHHHHH----EEEEE------EE---EEEEEEE---------------EEEEE--------HHHHHHHHHHHHHHHHHHHH---------EEEE---------HHHHHHHHHH----EEEEE--HHHHHHHHHH----EEEEEEE----EEE--HHHHHHHHHHHHHHHH----------EEEEEE-EEEEEEE----------------------EEEE-------EEEEEEEE------------EEEEEEEEEE-----EEEEE----------EEEEEEEEEEE-- CLP1_1 prof ------------EEEEE----EEEEEE-----EEEEEE--EEEEEEE-------EE-----EEEEEEE---EEEEE----EEEE-----HHHHHHHHHHHHHHHHHH--------EEEEE------HHHHHHHHHHHHHH----EEEEEE------------EEEE-----------------EEEE---------HHHHHHHHHHHHHHHHHHHH--------EEEE----------HHHHHHHHHH----EEEEE----HHHHHH-------EEEEE------E---HHHHHHHHHHHHHH-----------EEEEE----EEEEEE---------------------EEE-----------EEEE---------------EEEEEEEEE-----EEEEEE---------EEEE--------- CLP1_1 jnet ------------EEEEE----EEEEEE----EEEEEEE--EEEEE-EEE----EEEEE---EEEEEE----EEEEE-----EE--------HHHHHHHHHHHHHHHHHH------EEEEE------HHHHHHHHHHHHHH-----EEEEE-----------EEEEE-----------------EEEEE-------HHHHHHHHHHHHHHHHHHHHH---------EEEE---------HHHHHHHHHH----EEEEE-----HHHHHHH-----EEEEE----------HHHHHHHHHHHHHHHHH----------EEEEE--EEEEEE---------------------EEE-----HH----EEEEE-------------EEEEEEEEE------EEEEEE---------EEEEEEEE----- CLP1_1 sable ------------EEEEE----EEEEEE----EEEEEEEE-EEEE---EE---EEEEE----EEEEEEE---EEEEEE----EEE-----EEHHHHHHHHHHHHHHHHHH----EEEEEEEE-----HHHHHHHHHHHHHH---EEEEEEEE----------EEEEEEE---------------EEEE-----HHHHHHHHHHHHHHHHHHHHHHHH-------EEEEEE--------HHHHHHHHHHHH--EEEEEEE--HHHHHHHHH----EEEEEEEEEE------HHHHHHHHHHHHHHHHH-------EEEEEEE----EEEEE--------------------EEEEEE--------EEEEEE-------------EEEEEEEEEEE----EEEEEE---------EEEEEEEEE---- CLP1_1 proteus -------------EEEE-----EEEEE-----EEEEEEEEEEEE---E-----EEE-----EEEEEEE--EEEEEE---EEEE------HHHHHHHHHHHHHHHHHHHHH-----EEEEE------HHHHHHHHHHHHHH----EEEEE------------EEEEEEE---------------EEEEE--------HHHHHHHHHHHHHHHHHHHH---HH----EEEE--------HHHHHHHHHHH----EEEEE--HHHHHHHHHH----EEEEEE------E---HHHHHHHHHHHHHHHH---------EEEEE---EEEEEEE---------------------EEEE----HHHH-EEEEEEE----HHH-----EEEEEEEEE------EEEEEE---------EEEEEEEEE---- CLP1_1 sspro4 ------------EEEEE----EEEEEE----EEEEEEEEEEEEE--EEE---EEEEE---EEEEEEE----EEEEEE---EEEE------HHHHHHHHHHHHHHHHHHHH-----EEEEE------HHHHHHHHHHHHHHH---EEEEE-----------EEEEEEE----------------EEEEE----HHH-HHHHHHHHHHHHHHHHHHHHH-HH-----EEEE-------HHHHHHHHHHHHH---EEEEE----HHHHHHHHH----EEEEE----------HHHHHHHHHHHHHHHHH---------EEEEE---EEEEEE--------------------EEEEEE---HHHH-EEEEEE-----HHH-----EEEEEEEEEEE----EEEEEE---------EEEEEEEEE---- CLP1_1 psspred -----------EEEEEE---EEEEEEEE---EEEEEE---EEEEE-EE----EEEEEE---EEEEEEE--EEEEEE-E-EEEEE------EEHH-HHHHHHHHHHHHHHHHH---EEEEE------HHHHHHHHHHHHHHH---EEEEEE-----------EEEEEEE---------------EEEEE----HH--HHHHHHHHHHHHHHHHHHHHHHHH-----EEEE--------HHHHHHHHHHH----EEEEE--HHHHHHHHHH----EEEEE-----------HHHHHHHHHHHHHHHHH---------EEEEE---EEEEEE---------------------EEEE---------EEEE---------------EE-EEEE-EEE----EEEEEE---------EEEEEE-EE---- CLP1_1 spineX ------------EEEEE---EEEEEEEE----EEEEEEEEEEEEEEEEE----EEEEE---EEEEEEE---EEEEE--EEEEEEE-----EEE-----HHHHHHHHH--------EEEEE--------HHHHHHHHHHHH-----EEEE------------EEEEEEE---------------EEEEEE-------HHHHHHHHHHHHHHHHHHH---------EEEEE----E----HHHHHHHHHH----EEEEE---------------EEEEEEE-------------HHHHHHHHHHHHH-------------------EEEEEE--------EE-EEEEE---EEEE-----HHH---EEEEE-------------EEEEEEEEE------EEEEEE---------EEEEEEEEEE--- CLP1_1 raptorxss ------------EEEEE----EEEEEE----EEEEEEEEEEEEE--EEE----EEEE----EEEEEEE---EEEEEE---EEEE------HHHHHHHHHHHHHHHHHHH------EEEEE------HHHHHHHHHHHHHH----EEEEEEE----------EEEEEE----------------EEEEE--------HHHHHHHHHHHHHHHHHHHHH-H------EEEE---------HHHHHHHHHHH---EEEE-----HHHHHHHH-----EEEEE----------HHHHHHHHHHHHHHHH-----------EE----H-EEEEE---------------------EEEEE---HHH---EEEEE-------------EEEEEEEEEEE----EEEEE----------EEEEE---EE--- CLP1_1 SPARROW ------------EEEEE----EEEEEE-----EEEEEEE-EEEE--EEE----EEEE----EEEEEE----EEEEE-----EEE------EEE--HHHHHHHHHHHHHHH-----EEEEE------HHHHHHHHHHHHHH----EEEEE-------E----EEEEE-----------------EEEEE--------HHHHHHHHHHHHHHHHHHHHH--------EEEE--------HHHHHHHHHHHH---EEEEE---------HHH-----EEEEE----------HHHHHHHHHHHHHHHH-----------EEE-HHH-EEEEE---------------------EE-----HHHHH--EEEEE-------------EEEEEEEEEEE----EEEEEE---------EEEE---EE---- CLP1_1 *SPARROW --HHHHHH-----EEEE----EEEEEE----EEEEEEEE--EEEE--------EEEEE---EEEEEEE---EEEEEE----EEE-----HHHHHHHHHHHHHHHHHHHHH-----EEEEEE------HHHHHHHHHHHHHH----EEEE--H-H-EEEE--EEEEEEE---------------EEEEE--------HHHHHHHHHHHHHHHHHHHHH--------EEEE----EE---HHHHHHHHHHH--EEEEEEEHHHHHHHHHHHHHH-EEEEEE-----EEE-HHHHHHHHHHHHHHHHH-----------EEEE-EEEEEEEE---------------------EEE----HHHHHHHHHHHHH----HHHHHH-EE-EEEEEEE------EEEEE----------EEEEEEEEEEHHH CLP1_1 HMMSTR ------------EEEEE----EEEEEE----EEEEEEEE--EEE--EE-----EEEE----EEEEEE----EEEEE-----EE-EE---HHHHHHHHHHHHHHHHHHHHH------EEEEE-----HHHHHHHHHHHHHHH----EEEE--------------EEEE-------------E--EE-------HHH-HHHHHHHHHHHHHHHHHHHH--HHHHH--EEEE---HHH----HHHHHHHHH----EEEEE--HHHHHHHHHH-----HHEEE----------HHHHHHHHHHHHHHHHH-----E--EEEEEE---EEEEEE---------------------EEEE---HHHH--EEEEEE-----HHHH----EEEEEEEEEEE----EEEEEE----------EEEEEEEE---- CLP1_1 porter ------------EEEEE----EEEEEE----EEEEEEEE-EEEEE-EEE-----EEE----EEEEEEE--EEEEEE---EEEEEE----HHHHHHHHHHHHHHHHHHHHH-----EEEEE------HHHHHHHHHHHHHH----EEEEEE-----------EEEEEEEE--------------EEEEE--------HHHHHHHHHHHHHHHHHHHHH--------EEEE---EE---HHHHHHHHHHH----EEEEE--HHHHHHHHHH----EEEEE-----------HHHHHHHHHHHHHHHHH--------EEEEEE--EEEEEEE--------------------EEEEEE---HHH---EEEE------HHH-----EEEEEEEEEE-----EEEEEE---------EEEEEEEEEEE-- CLP1_1 spine ------------EEEEE----EEEEEEE---HHHHHHHHHHHHHH---------EEE----EEEEEEE----EEE----EEEEE-----EEEEE--HHHHHHHHHHHHHHHH---EEEEE--------HHHHHHHHHHHH------EEEEE-----EE------EEEE---------------EEEE---------HHHHHHHHHHHHHHHHHHH----------EEE----------HHHHHHHHHH----EEEEE--HHHHHHHHH-----EEEEEE----------HHHHHHH-HHHHHHHH-------------------EEEE----------------------EEEE------HHHHHHEE------HHHHHH----EEEEEE-------EEEEE-----------EEEEEEEE---- CLP1_1 nnssp -------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----------------EEEEEEE--EEEEEE--EEEEEE-----EEEEE--HHHHHHHHHHHHHHHH---EEEEE------HHHHHHHHHHHHHHH----EEEEEE----EEEE-----EEEEE--------------EEEEE--------HHHHHHHHHHHHHHHHHHHHHHHH------------------HHHHHHHHHH----EEEEE-HHHHHHHHHHH----EEEEEE----------HHHHHHHHHHHHHHHHH--------------HHHEEEEE--------------------EEEEEE-------EEEEEEEE----------------EEEEEE------EEEEE--------HHHHHHHHHHHHH-- CLP1_1 pssfinder -------------EEHHH--EEHHHEE----HHHHHHHHHHHHHH---------EEE----EEEEEE----EEEE----EEEEE-----EEEEE--HHHHHHHHHHHHHHH----EEEEEE-------HHHHHHHHHHHHH----EEEEEE-----EE------EEEE---------------EEEEE--------HHHHHHHHHHHHHHHHH--EE----EE--EEEE---------HHHHHHHHH----EEEEEE--HHHHHHHHHH----EEEEEEE----EEE--HHHHHHHHHHHHHHHH-------------EEE--EEEEEE---------------------EEEEE-----HHHHEEE-------HHHH-------EEEEE------EEEEEE----------EEEEEEEE----- CLP1_1 sspal ---------------HHHHHHHHHEEE-HHHHHHHHHHHHHHHHH---------EEEE----EEEEEEE-EEEEE---EEEEEEE----HHHHHHHHHHHHHHHHHH---------EEEE--------EEEEEEE----------EEEEEEEE--EEEE------EEEE--------EEEE--EEEEE-------HHHHHHHHHHHHHHHHHH-------EEEEEEEE----------HHHHHHHHEEEEEEEEEEEHHHHHHHHHHH----EEEEEEE-----HHHHHHHHHHH--HHHHHHHHH--------EEEEEEE--EEEEEEE-------------HHHHHHEEEEEEE--HHHHHHHHH--------------EEEEEEEEE-----EEEEEEEE---------EEEEE-------- CLP1_1 ssp -----------EEEEEE----EEEEEE----EEEEEEEE----EEE-------EEEEE---EEEEEEE--EEEEEEEE--EEEEE-----EE-HHHHHHHHHHHHHHHH-----EEEEEE------HHHHHHHHHHHHHH---EEEEEEE------------EEEEEE--------------EEEEEEE-------HHHHHHHHHHHHHHHHHHHHH-------EEEEE------HHHHHHHHHHHHH----EEEEE-----HHHHHHH----EEEEEE-----EEE--HHHHHHHHHHHHHHHH---------EEEEE---EEEEEEE-------------------EEEEEEE----HHHHEEEEEEE-------------EEEEEEEEE----EEEEEEE---------EEEEEE-EEE--- CLP1_1 sspred -----------EEEEEE----EEEEEEE---EEEEEEEEEEEEEEEEEE----EEEEE---EEEEEE----EEEEEE------------------HHHHHHHHHHHHHH------EEEEE------HHHHHHHHHHHHHH-----EEEE-----------EEEEEEE-----------------EEE---------HHHHHHHHHHHHHHHHHHHHH--------EEEE--------HHHHHHHHHHH----EEEEE-----HHHHHHHH----EEEE-----------HHHHHHHHHHHHHHHHH------------------EEEE----------------------EEEE----H-----EEEEE-------------EEEEEEEEEE-----EEEEEE---------EEEEE--E----- CLP1_1 netsurfp -------------EEEE----EEEEEE----EEEEEEEE-EEEE---EE----EEEE----EEEEEE----EEEEEE----EEE--------HHHHHHHHHHHHHHHHHH-----EEEEE------HHHHHHHHHHHHHH----EEEEEE------E----EEEE------------------EEEEE----HHH-HHHHHHHHHHHHHHHHHHHHHHHH-----EEE----------HHHHHHHHHHH---EEEEE--------HHH-------EEEE----------HHHHHHHHHHHHHHHHH-----------EE-----EEEEE---------------------EEE-----HH----EEEE--------------EEEEEEEEEE-----EEEEEE---------EEEEEEEEE---- CLP1_1 soprano ------------EEEEE----EEEEEE----EEEEEEEE-EEEEE-EE-----EEEE----EEEEEEE---EEEEE----EEEE-------HHHHHHHHHHHHHHHHHHH-----EEEEE------HHHHHHHHHHHHHH-----EEEEE-----------EEEEEEE---------------EEEEE--------HHHHHHHHHHHHHHHHHHHHH--------EEEE---------HHHHHHHHHH----EEEEE---HHHHHHHHH----EEEEEE----------HHHHHHHHHHHHHHHH----------EEEEE---EEEEEE---------------------EEEE----HHH---EEEEE-------------EEEEEEEEEE-----EEEEEE---------EEEEEEEEE---- CLP1_1 consensus MSSLAVRDPAMDRSLRSVFVGNIPYEATEEQLKDIFSEVGSVVSFRLVYDRETGKPKGYGFCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGPAAPIIDSPYGDPIDPEDAPESITRAVASLPPEQMFELMKQMKLCVQNSHQEARNMLLQNPQLAYALLQAQVVMRIMDPEIALKILHRKIHVTPLIPGKSQSVSVSGPGPGPGPGLCPGPNVLLNQQNPPAPQPQHLARRPVKDIPPLMQTPIQGGIPAPGPIPAAVPGAGPGSLTPGGAMQPQLGMPGVGPVPLERGQVQMSDPRAPIPRGPVTPGGLPPRGLLGDAPNDPRGGTLLSVTGEVEPRGYLGPPHQGPPMHHASGHDTRGPSSHEMRGGPLGDPRLLIGEPRGPMIDQRGLPMDGRGGRDSRAMETRAMETEVLETRVMERRGMETCAMETRGMEARGMDARGLEMRGPVPSSRGPMTGGIQGPGPINIGAGGPPQGPRQVPGISGVGNPGAGMQGTGIQGTGMQGAGIQGGGMQGAGIQGVSIQGGGIQGGGIQGASKQGGSQPSSFSPGQSQVTPQDQEKAALIMQVLQLTADQIAMLPPEQRQSILILKEQIQKSTGAS CSTF2T_1 sequence ----------------EEEEE-------HHHHHHHHHH---EEEEEEE----------EEEEEE--HHHHHHHHHHH--------EEEE-------HHHHHH----------------------HHHHHHH-----HHHHHHHHHHHHHHHHH-HHHHHHHHHH---HHHHHHHHHHHH----HHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH-------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHH--HHHHH---HHHHHHHHHHHHHHHHHH--- CSTF2T_1 psipred --------HHH-----EEEEE-------HHHHHHHHHH---EEEEEEEEE----------EEE---HHHHHHHHHHH--------EEEEE-------HHHHH----------------------HHHHHHHH----HHHHHHHHHH--EEE---HHHHHHHHHH---HHHHHHHHHHHH----HHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHH-----HHHHHHH----------------------HHH---HHHHH-----HHHHHHHHHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHH--HHHHH----HHHHHHHHHHHHHHHH---- CSTF2T_1 prof ---------------EEEEEE-----HHHHHHHHHHH-------EEEEE-----------EE----HHHHHHHHHH---------EEEEE----------------------------------HHHHHHHH-----HHHHHHHHHHHHHHH---HHHHHHHHH---HHHHHHHHHHH-----HHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------EEEE-------------------------------------------------------------------------------------HHHHH----------------------------------------------------------EEEEEE----------------------------------------------------------------------------HHHHHHHHHH----EE-----HHHHHHHHHHHHH------ CSTF2T_1 jnet ----------------EEEEE-------HHHHHHHHHH---EEEEEEEE---------EEEEEE--HHHHHHHHHH---------EEEEEE----------------------------------HHHHHH-----HHHHHHHHHHHHHHH---HHHHHHHHHH---HHHHHHHHHHH-----HHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHH--HHHHHH--HHHHHHHHHHHHHHHH----- CSTF2T_1 sable -----------HHHHEEEEEE-------HHHHHHHHHHH---EEEEEEEE----EEE-EEEEEE--HHHHHHHHHHH-------EEEEEEE---HHHHHHHHH----------------------------------HHHHHHHHHHHHHH---HHHHHHHHHH---HHHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHH----HHHHHH----HHHHHHHHHHHHH------ CSTF2T_1 proteus ----------------EEEEE-------HHHHHHHHHHH--EEEEE--E------E--EEEEEE--HHHHHHHHHHH---E----E-EEE----------H--------EEE---------HH-HHHHHHHH----HHHHHHHHHHHHHHH---HHHHHHHHHH-HHHHHHHHHHHHHHHH--HHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------EEEE--------------------------------HHH------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHH-----------------------------------------------E---------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHH---- CSTF2T_1 sspro4 ----------------EEEE--------HHHHHHHHHHH--EEEEEEEE---------EEEEEE--HHHHHHHHHHH---EE--EEEEEE-------HHHHHHH--------------------HHHHH-------HHHHHHH------EE---HHHHHHHHHH----HHHHHHHHH------HHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHH---HHHHH---HHHHHHHHHHHHHHHH----- CSTF2T_1 psspred ---------------EEEEE--------HHHHHHHHHHH--E-EEEEEE---------EEEEEE--HHHHHHHHHHH---EE--EEEEE--H---HHHHHHHHH--------------------HHHHHHHHHH--HHHHHHHHHHHHHHHHH-HHHHHHHHHH-HHHHHHHHHHHHHHH---HHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHH---HHHHHH--HHHHHHHHHHHHHHHHH---- CSTF2T_1 spineX ----------------EEEE--------HHHHHHHH-----EEEEEEEE----------EEEEE--HHHHHHHHHHH--------EEEE-------------------------------------------------HHH--------------HHHHHHHH------HH------------HHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHH------HHHHH----HH--HHHHHHHHHH------ CSTF2T_1 raptorxss --------HHH----EEEEEE-------HHHHHHHHHH---EEEEEEEE---------EEEEE---HHHHHHHHHH-----E---EEEEE----------H-----------------------HHHHHHHH----HHHHHHHHHHHHHHHH--HHHHHHHHHH---HHHHHHHHHHH-----HHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HH----------------------------------------------------------------------------H--------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHH--HHHHH---HHHHHHHHHHHHHHH------ CSTF2T_1 SPARROW --------HHH-----EEEEE-------HHHHHHHHHH---EEEEEEEE----------EEEE---HHHHHHHHHHH---EE---EEEE------------HH----------------------HH----------HHHHHHH-------H-HHHHHHHHHHH--HHHHHHHHHHHHH-----HHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HH------HHH-----HHHHHHHHHHHHHHH------ CSTF2T_1 *SPARROW -----E------H--EEEEEE----HHHHHHHHHHHHHHEEEEEEEEEE------EE---EEEE--HHHHHHHHHHH---EE---EEEEE-------HHHHHH------------------HH-HHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHH---H-HHHHHHHHHH----HHHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------EEEE--------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHH----------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHH--HHHHHH--HHHHHHHHHHHHHHHHH---- CSTF2T_1 HMMSTR ----------------EEEEE-------HHHHHHHHH----EEEEEEEE------EEEEEEEEE--HHHHHHHHHHH---E----EEEEEE--------HHH-----------------------HHHHHHH----HHHHHHHHHHHHHHH---HHHHHHHHH--HHHHHHHHHHHH------HHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------EE-------------------------------------------------------------------------------HHHH-----HHHH--HHHHHHH-----------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHH---HHHHH---HHHHHHHHHHHHHHH------ CSTF2T_1 porter ----------------EEEEE-------HHHHHHHHHH---EEEEEEEE--------EEEEEEE--HHHHHHHHHH---EEE---EEEEE-------HHHHH-------------------------EEEEE----HHHHHHHHHH-HHHHH--HHHHHHHHHH--HHHHHHHHHHHH-----HHHHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH---------------------------------HHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHH-H----------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHH-HHHHH---HHHHHHHHHHHHHHHH----- CSTF2T_1 spine ----------------EEEE--------HHHHHHHHHH---EEEEEEEE-----------------HHHHHHHHHH---------EEEE--------HHHHH-----------------------------------HHHHHHHHHHHHHH----HHHHHHH----HHHHHHHHHHHHHHH----HHHHHH----EE----------EEE----------------------------------------------------------------------------------------------------------------------------------EEEEE-----------------------------------------------------------------------HHHHHHHHHHHHHHHHHHH----------------------------------------------------------------------------------------------------EEE-----------------------------------HHHHHHHHHHHHH---------------EEEHHHHHHHH---- CSTF2T_1 nnssp ----------------EEEE--------HHHHHHHHHHH--EEEEEEEEE--------EEEEEE--HHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHH--------------------HHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHH--HHHHHHHHHHHH-----------EEEEE---------------------------------------------------------------------------------------------------------------------------------EEEEE---------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------------------------------------------------------------------------------------EEEEE-------------------------------HHHHHHHHHHHHHHH--HHHHHH--HHHHHHHHHHHHHHHH----- CSTF2T_1 pssfinder ---------------EEEEEE----HHHHHHHHHHHHHH--EEEEEEE------------------HHHHHHHHHH---------------------HHHHH-----------------------HHHHHH-----HHHHHHHHHH-HHHHH--HHHHHHH-----HHHHHHHHHHHHHHH--HHHHHHHHH----------------------------------EEE--------------------------------------------------------------------------EEEE---------------------------------EEEEEEE-----------------------------------------EEEEE----------------------HHHHHHHHHHHHHHHHHHHHH--EEEEEEE-------------EE--------------------------------------------------------------------------EEEEE----------------------------------HHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHH----- CSTF2T_1 sspal -----------------EEEE----HHHHHHHHHHHHHHEEEEEEEEEE-------------HHHHHHHHHHHHH--------------HHHHHHHHHHHHHHH-------------------HHHHHHHHHHHH--HHHHHHHHHEEEEEEEHHHHHHHHHHH--HHHHHHHHHEEEEEEE--HHHHHHHHH-EEEE-----EEEEEEEE----------------------------HHHHH------------------------------------------------------------------------------------------------EEEEEEEEEE---------------------------------------EEEE----------------------HHHHHHHHH---HHHHHHHHH----------------------------------EEEEEEE---EEEE---------------------------------------------------EEEE-----------------------------HHHHHHHHHHHHHHHHHH-HHHHHHH--HHHHHHHHHHHHHHH----- CSTF2T_1 ssp ------------------EEE-------HHHHHHHHHH-------EEE-----------EEEEE--HHHHHHHHHH----------EEEE------------------------------------------------HHHHHHH---------HHHHHHHHH--------------------HHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHH--------------------HHHHHH------ CSTF2T_1 sspred ----------------EEEEE-------HHHHHHHHHH---EEEEEEEE----------EEEE---HHHHHHHHHHH--------EEEEE-------HHHHHHHHH-----------------HHHHHHHH--------HHHHH---------HHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHH---HHHHH---HHH-HHHHHHHHHHHHH---- CSTF2T_1 netsurfp ----------------EEEE--------HHHHHHHHHH----EEEEEEE----------EEEE---HHHHHHHHHHH--------EEEE-E----------------------------------H-HHHHH-----HHHHHHHHHHHHHHH--HHHHHHHHHH--HHH--HHHHHHHH----HHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH--------HHHHHHHHHHHH---- CSTF2T_1 soprano ----------------EEEEE-------HHHHHHHHHH---EEEEEEEE----------EEEEE--HHHHHHHHHHH--------EEEEE-------HHHHH----------------------HHHHHHH-----HHHHHHHHHHHHHHH---HHHHHHHHHH--HHHHHHHHHHHHH----HHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H--------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHH--HHHHH---HHHHHHHHHHHHHHHH----- CSTF2T_1 consensus MASGSGDSVTRRSVASQFFTQEEGPGIDGMTTSERVVDLLNQAALITNDSKITVLKQVQELIINKDPTLLDNFLDEIIAFQADKSIEVRKFVIGFIEEACKRDIELLLKLIANLNMLLRDENVNVVKKAILTMTQLYKVALQWMVKSRVISELQEACWDMVSAMAGDIILLLDSDNDGIRTHAIKFVEGLIVTLSPRMADSEIPRRQEHDISLDRIPRDHPYIQYNVLWEEGKAALEQLLKFMVHPAISSINLTTALGSLANIARQRPMFMSEVIQAYETLHANLPPTLAKSQVSSVRKNLKLHLLSVLKHPASLEFQAQITTLLVDLGTPQAEIARNMPSSKDTRKRPRDDSDSTLKKMKLEPNLGEDDEDKDLEPGPSGTSKASAQISGQSDTDITAEFLQPLLTPDNVANLVLISMVYLPEAMPASFQAIYTPVESAGTEAQIKHLARLMATQMTAAGLGPGVEQTKQCKEEPKEEKVVKTESVLIKRRLSAQGQAISVVGSLSSMSPLEEEAPQAKRRPEPIIPVTQPRLAGAGGRKKIFRLSDVLKPLTDAQVEAMKLGAVKRILRAEKAVACSGAAQVRIKILASLVTQFNSGLKAEVLSFILEDVRARLDLAFAWLYQEYNAYLAAGASGSLDKYEDCLIRLLSGLQEKPDQKDGIFTKVVLEAPLITESALEVVRKYCEDESRTYLGMSTLRDLIFKRPSRQFQYLHVLLDLSSHEKDKVRSQALLFIKRMYEKEQLREYVEKFALNYLQLLVHPNPPSVLFGADKDTEVAAPWTEETVKQCLYLYLALLPQNHKLIHELAAVYTEAIADIKRTVLRVIEQPIRGMGMNSPELLLLVENCPKGAETLVTRCLHSLTDKVPPSPELVKRVRDLYHKRLPDVRFLIPVLNGLEKKEVIQALPKLIKLNPIVVKEVFNRLLGTQHGEGNSALSPLNPGELLIALHNIDSVKCDMKSIIKATNLCFAERNVYTSEVLAVVMQQLME Symplekin_1N sequence -------------------------------HHHHHHHHHHHHH----HHHHHHHHHHHHHHH------HHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHEE-------------------------------HHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHH-----HHHHHHHHHHH--------HHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHH----HHHHHH------------------HHHH-------------------------------------HH---------HHHHHHHHHHHH--------HHHHH----------HHHHHHHHHHHHH----------------------HHHHHHHHHHHHHHHH-------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------HHHHHHHHHHHH---------HHHHHHHH-----HHHHHHHHHH-----HHHHHHHHHHHHHH-----HHHHHHHHHH-----HHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHH-----------------------HHHHHHHHHHHHHH------HHHHHHHHHHH--HHHHHHHHHHHHHHHHH-----HHHHHHHHH-----HHHHHHHHHHH-------HHHHHHHHHHHHH-----EEEEE------HHHHHHH--------HHHHHHHHHHHH---------------HHHHHHHHH--------HHHHHHHHHHHH-------HHHHHHHHHHHH- Symplekin_1N psipred --------------HHHH-HHH---------HHHHHHHHHHHHH----HHHHHHHHHHHHHHH-----HHHHHHHHHHHHH----HHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHEEE------------------------------HHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHH--HHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHH--HHHHHHHH---HHHHH------HHHHHH---------------------------------------HHHHHH---HHHHHHHHHHHHHH--HHHHHHHHHHH-HHH-------HHHHHH--------------------------------HHHHHHH--------------------------------------------HHHH-HHHHHHHHHHH----HHHHHHHHHHHHHHHHHH-HHHH----HHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHH-----HHHHHHHHHH-----HHHHHHHHHHH-----HHHHHHHHHHHHH-----HHHHHHHHHHHH----HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHH----------------------HHHHHHHHHHHHHHH---HHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHH-----HHHHHHHHH----HHHHHHHHHHHHH------HHHHHHHHHHHHH-----EEEEHHHH---HHHHHHHHHHHH---HHHHHHHHHHHH---------------HHHHHHHHHH-------HHHHHHHHHHHH-------HHHHHHHHHHH-- Symplekin_1N prof -----------------------------HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHH-------HHHHHHHHH-----HHHHHHHHHHHHHHHH--HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHEE-------------------------------HHHHHHHHHHHHHHHHHHH--------EEEEEHHHHHHHHHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHH---HHHHHHHHHHHHHHHH-------------------------------------------------------------HHHHHHHHHHH--------HHHH-------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHH-------------HHHHHHHHH----HHHHHHHHHHHHHH----HHHHHHHHHHHHHHH---------HHHHHHHHHHHHHHH-------HHHHHHHHH-----HHHHHHHHHH------HHHHHHHHHHHHH-----HHHHHHHHHHH-----HHHHHHHHHHHHHH------HHHHHHHHHHHHHHHH----------------------HHHHHHHHHHHHHH-----HHHHHHHHHH----HHHHHHHHHH---HHHHH----HHHHHHH-------HHHHHHHHHHHH------HHHHHHHHHHHH-----EEEEEE------HHHHHHHHHHHH----HHHHHHHHHEE---------------HHHHHHHHH--------HHHHHHHHHHH---------HHHHHHHHHH-- Symplekin_1N jnet -------------------------------HHHHHHHHHHHHH----HHHHHHHHHHHHHHH----HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHEEE------------------------------HHHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHH---HHHHHHH------HH----------HHH-------------------------------------HHHH-------HHHHHHHHHHHHHH-----HHHHHHH----------HHHHHHHHHHHHH-----------------------------------------------------------------------------------------HHH------HHHHHHHHHHHHHHHHHH-HHHH---HHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHH------HHHHHHHHH-----HHHHHHHHHH-----HHHHHHHHHHHHHH-----HHHHHHHHHHHHH---HHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHH--------------------HHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHH----HHHHHHHHHHHHH------HHHHHHHHHHHHH-----EEEEE------HHHHHHHHHHHH---HHHHHHHHHHHH---------------HHHHHEHE---------HHHHHHHHHHHHH------HHHHHHHHHHHH- Symplekin_1N sable -------------HHHHH-----------HHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHH---HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHH------------------------------HHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------HHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHH--HHHHHHHHH---------------HHHHHH---------------------------------HHHHHHHHHH---HHHHHHHHHHHHHH---HHHHHHHHHHHHH-----HHHHHHHHHH-------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHH-HHHH----HHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHH----HHHHHHHHHHH-----HHHHHHHHHHH---HHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHH-----------------HHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHH---HHHHHHHHHHHHHHHH------HHHHHHHHH----HHHHHHHHHHHHH------HHHHHHHHHHHHH----EEEEEE------HHHHHHHHHHHH---HHHHHHHHHHH----------------HHHHHHHHH--------HHHHHHHHHHHHH------HHHHHHHHHHH-- Symplekin_1N proteus ------HHHEHEEHHHHHHHHH-------H-HHHHHHHH--HH-------HHHHHHHHHHHHH-----HHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHH-HHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHH-------HEEEEEHHHHEEEEEE------------------H-----------HHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHH-HHHHHHHHHHHHH--------HHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHH----HHHHHHH----------------HHHHHHH----------------------HHHHHH---------HH--H-----HHHHHHHHHHH----HH--HHHHHH---HH---HHHHHHHHHHHHHHH--H--------H-----------------EEEEE--------EE----------------------------------------EEEEE---------HHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHH---HHHHHHHHHHH------HHHHHHHHHHH---HHHHHHHHHHHHHHHH---HHHHHHHHHHHH-----HHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHH----HHHHH-------------HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHH-----HHHHHHHHHHHHH------HHHHHHHHHHHH-----HEEEEEHH----HHHHHHH--HH----HHHHHHHHHHHHH--------------HHHHHHHHH--------HHHHHHHHHHHHHHH--HHHHHHHHHHHHHH- Symplekin_1N sspro4 --------------HHH--------------HHHHHHHHHHHHHH---HHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHH------------------HHH---------HHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHH---HHHHHHHHH-HHHHH--------HHHHHH-------------------------HHHH-----HHHHHHHHHHH--HHHHHHHHHHHHHH---HH-HHHHHHH---------HHHHHHHHH--------------------------------------------------------------------------------HHHHH---HHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHHH---HHHHHHHHHHH-----HHHHHHHHHHH---HHHHHHHHHHHHHHHH---HHHHHHHHHHHHHH---HHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHH----HHH------------HHHHHHHHHHHHHHHHH---HHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHH----HHHHHHHHH----HHHHHHHHHHHHH------HHHHHHHHHHHHH----EEEEEEE-----HHHHHHHHHHHHH--HHHHHHHHHHHHH--------------HHHHHHHHHH-------HHHHHHHHHHHHH------HHHHHHHHHHHH- Symplekin_1N psspred --------------HHH--------------HHHHHHHHHHHHHH---HHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHH-------------------------------HHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------HHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHH---HHHHHHH-----------------HHHHHHH----------------------HHHH----------HHH------HHHHHHHHHHHHHH-----HHHHHHH----H----HHHHHHHHHHHHHHHHHH------HHHHH----HHHHHHHHHHHHHHHHHHHH------------------HHHHHH------------HHHHH-----HHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHH-----HHHHHHHHHH-----HHHHHHHHHHH--HHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHH------HH--------------HHHHHHHHHHHHHH----HHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHH----HHHHHHHHH----HHHHHHHHHHHHH------HHHHHHHHHHHHH----EEEEEE------HHHHHHHHHHHHH--HHHHHHHHHHHHH--------------HHHHHHHHHH-------HHHHHHHHHHHHH------HHHHHHHHHHHH- Symplekin_1N spineX --------------------------------HHHHHHHHHHHH----HHHHHHHHHHHHHHH---HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHE------HHHHHHHHHHHHHH-HEEE---------EHHHHHH--EEEEEE------------------------------HHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHH--HHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHH----HHHHHH-------------------------------------------------EEE------------------HHHHHHHHHHHHH-----------EEE----------------------------------------------------------------------------------------------------------EEEEE---------HHHHHHHHH-HHH-EEEEEEEEEE----EEEEEEEEEEEEE--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHH-----HHHHHHHHHHH------HHHHHHHHHHH--HHHHHHHHHHHHHHHH-----HHHHHHHHHHH-----HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHH----------------------HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHH-----HHHHHHHHHHH-------HHHHHHHHHHHH------EEEEE------HHHHHH---HH----HHHHHHHHHHHH---------------HHHHHHHHH--------HHHHHHHHHHHH-------HHHHHHHHHHHH- Symplekin_1N raptorxss ----------------HEE------------HHHHHHHHHHHHH----HHHHHHHHHHHHHHHH--HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHE------------------HHH---------HHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHH-HHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHH---HHHHHHHHH--HHHHHH-------HHHHHH------------------------HHH----------HHH-H----HHHHHHHHHHHHH---HH-HHHHHHHH------------------------------------------HHHH----------------------------------H----------------HHHHH--------E---------HHHHHHHHHHHHHHHHHH-HHHH----HHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHH----HHHHHHHHHHH------HHHHHHHHHH---HHHHHHHHHHHHHHHHH-----HHHHHHHHHHHH---HHHHHHHHHHHHHH-------HHHHHHHHHHHHHHH-----HHH--------HHHHHHHHHHHHHHHHHH------HHHHHHHHHHHH---HHHHHHHHHHHHHHHHH-----HHHHHHHHH----HHHHHHHHHHHH-------HHHHHHHHHHHH------EEEEEE-----HHHHHHH-HHH----HHHHHHHHHHHH---------------HHHHHHHHHH-------HHHHHHHHHHHH-------HHHHHHHHHHH-- Symplekin_1N SPARROW -------------HHHHH-------------HHHHHHHHHHHH----HHHHHHHHHHHHHHHHH---HHHHHHHHHHHHH-----HHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHEEEEE------------------HHH---------HHHHHHHHHHHHHHHHHHH--------HHHHHHHHHHHHHH--HHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHH-HHHHHHHH-H-HHHHH--------HHHHH-------------------------------------HHHH------HHHHHHHHHHHHH----H-HHHHHHH-------------------------------------------------------------------------------------------------------------HH----------HHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHH--HHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHH-----HHHHHHHHHHH-----HHHHHHHHHH---HHHHHHHHHHHHHHHH-----HHHHHHHHHHHHH---HHHHHHHHHHHHHH------HHHHHHHHHHHHHHHH-----HHH------------HHHHHHHHHHHHHHHH----HHHHHHHHHHH----HHHHHHHHHHHHHHHHH-----HHHHHHHHH-----HHHHHHHHHHHH------HHHHHHHHHHHHH----HHHHEHHH----HHHHHHH-HHH----HHHHHHHHHHHH---------------HHHHHHHHHH-------HHHHHHHHHHHH-------HHHHHHHHHHH-- Symplekin_1N *SPARROW --------EEHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHEEEEE------------------EE-------EE-HHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------HHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHH-------------------HHHHHHHHHHHHHHHHHHHHEE----HHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHH------------------------HHHHHHHHHHHHH---HHHHHHHHHHHHH----------------------HHHHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHH--HH-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHH-HHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHH---HHHHHHHHHH-----HHHHHHHHHHHHH----HHHHHHHHHHHHHHH----EEE-----H--HHHHHHHHHHHHE--HHHHHHHHHHHHH--------------HHHHHHHHHHH-HHH--HHHHHHHHHHHHHH-----HHHHHHHHHHHHH Symplekin_1N HMMSTR ------------HHHHHHHH----------HHHHHHHHHHHHH-----HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHH-------------------HHH---------HHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHH-----HHHHH---------------------HH------------------------------------HHHHH-------HHHHHHHHH------HH-HHHHHHHH-HHHH----HHHHHHHHHHHHHHHH--------------------------EEEE---------EEEE--------------------------------------EEEEE---------HHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHH-------HHHHHHHHH------HHHHHHHHHHH-----HHHHHHHHHHHHH-----HHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------HEE-------------HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHH--HHH------HHHHHHHH-----HHHHHHHHHHHHH------HHHHHHHHHHHH-----HHHHHHH-----HHHHHHHHHHHH---HHHHHHHHHHHH---------------HHHHHHHHH--------HHHHHHHHHHHHHH-----HHHHHHHHHHH-- Symplekin_1N porter --------E----HHHHHE------------HHHHHHHHHHHHH-----HHHHHHHHHHHHHH---HHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHH-----------------EEE-----------HHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHH----HHHHHHH-----------------HHHHHH----------------------------------HHHHHHHHH----HHHHHHHHHHHHH-HHH-HHHHHHH--HHHH--HHHHHHHHHHHHHHHHHH------HHHHH------HHHHHHHHHHHHHH----HHHHHHHHHHHH-------HHHHHHH------------HHH-----EEEEE---------HHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHH--------HHHHHHHH-----HHHHHHHHHH------HHHHHHHHHHHHH---HHHHHHHHHHHHHH----HHHHHHHHHHHHHHH--H-HHHHHHHHHHHHHHHHH----HHHH--------------HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHH-HHHHH-----HHHHHHHH-----HHHHHHHHHHHH-------HHHHHHHHHHHHH-----EEEEE------HHHHHHH-HHHH---HHHHHHHHHHHHH--------------HHHHHHHHH--------HHHHHHHHHH-H------HHHHHHHHHHHH-- Symplekin_1N spine ---------HHHHHHHHHHHHH----------HHHHHHHHHHHHH-------HHHHHHHHHHH----HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---EEEEE------HHHHHHHHH--EEEEE----------------------------EEEEHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHH----HHHHHHH----------------HHHHHHH----------------------HHHHHH-------HHHHHHHHH-----HHHHHHHHHH-------HHHHHHH--------HHHHHHHHHHHHHHHHHH-----HHHHHHHHH--HHHHHHHHHHHHHHHHHHH----EEEE-------HHHHHHHHHH-----EEE------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHH-------EEEEEE----HHHHHHHHHHHHHHHH--------HHHHHHHHH----HHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------EEEE-------------HHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHH-----HHHHHHHHHHHH-------HHHHHHHHHHHHHH----EEEEE------HHHHHHHHHHHHH---HHHHHHHHHHH-----------------HHHHHHH--------HHHHHHHHHHHHHH-----HHHHHHHHHHHHH Symplekin_1N nnssp -------EEEEEEEEEEEEE-----------HHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----EEEEEE-----EEEEEEEEE--EEEEE------------------------------HHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHH----HHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHH----HHHHHHH---------------HHHHHHHH-------------------------------------HHHHHHH--HHHHHHHHHHHHHH---------------------HHHHHHHHHHHHHHHHHH-----------------HHHHHHHHHHHHHHHHHH---EEEEE-------HHHHHHHHHHH---------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHH-----------EEEEEEE-----HHHHHHHHHH----------HHHHHHHHHH-HHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------EEEEEE-----------HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHH------------HHHHHHHHH------EEEEEEEE---------HHHHHHHHHHHHHH---EEEEEE------HHHHHHHHHHHHH--HHHHHHHHHHHH------------------EEEEEE--------HHHHHHHHHHHHHHH----HHHHHHHHHHH-- Symplekin_1N pssfinder HH------HHHHHHHHHHHHH-----------HHHHHHHHHHHHH-----HHHHHHHHHHHHH---HHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----EEEE-----HHHHHHHHHHHHHHHH----HHHHH-HHHHH----------------HHHHHHHHHHHHHHHHHHH---------HHHHHHHHHHHH---HHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHH-----HHHHHH---------------HHHHHHHHH--------------------------------HHHHHHHHH---------HHHHHHHHHH-----HHHHHHH--------HHHHHHHHHHHHHHHHHH-----HHHHHHH----HHHHHHHHHHHHHHHHHHH----EEEE-----HHHHHHHHHH-------EEE----HHHH----HHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHH------------HHHHHH-----HHHHHHHHHHHH------EE--HHHHHHHH----HHHHHHHHHHH------HHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHH-------EEEE----HHHHHH-HHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------HHHHHHH----HHHHHHHHHHHHH-------HHHHHHHHHHHH-------EEEEE-----HHHHHHHHHHHH---HHHHHHHHHHHH---------------HHHHHHHHH--------HHHHHHHHHHHHHH-----HHHHHHHHHHHHH Symplekin_1N sspal -------EEEE--EEEEEEE---------HHHHHHHHHHHHHH----------HHHHHHHHH---HHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHH--EEEEEEE----HHHHHHHHHHHHEEEE----------HHHHHHHHHHH---------HHHHHHHHHHHHHHHHHEEEE-------HHHHHHHHHHHHHH--HHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHH----HHHHHHEEEEEEE---HHHHHHHHH---------------HHHHHHHHH----HHHHHHHHH----------------------HHHHH----------EEEEEEEE--HHHHHHHHHH------HHHHHHHHHHHHHHH--------------------------EEEE--EEEE-------EEEEEEE-------HHHHH---------EEEEE---------HHHHHHHHHHHH---HHHHHHHHH-HHHHHHHHH---HHHHHHHEEEEEEE-----------HHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHH-----------EEEEEEE------HHHHHHHHHHHH----EEEEHHHHHHHHHHH----EEEEEEEEEEE--HHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHH------EEEE-----------HHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHH-HHHHHHHHHHH---------HHHHHHHHH----HHHHHHHHHH----------HHHHHHHHHH------EEEEEHHHHHHHH-HHHHHHHHHHH-----HHHHHHHHH----------------HHHHHHHHH---EEEEEEEEEE-----------HHHHHHHHHHHHHH- Symplekin_1N ssp ---------HHH-HHHHHHHHHH--------HHHHHHHHHHHHHH----HHHHHHHHHHHHHH-------HHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE-----HHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHEEE------------------------------HHHHHHHHHHHHHHHHHHH---------HHHHHHHHHHHHH--HHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHH--HHHHHHHH--HH---------------------------------------------------HHHHHHH---------HHHHHHH-HHH--HHHHHHHHHHHHHHH-----HHHHHHHHHHHHHH-----------HH-----------------HH------------------------------------------HHHHHHHHHHH------------HHHHHHHH-HHHH-HHHHHHHHH----HHHHHHHHHH-HH----HHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHH--------HHHHHHHHHHHHHH--------HHHHHHHH-----HHHHHHHHHHH----HHHHHHHHHHHHH-------HHHHHHHHHHH------HHHHHHHHHHHHH----HHHHHHHHHHHHHHHHH----HHHHH--------------HHHHHHHHHHH-------HHHHHHHHHHH--HHHHHHHHHHHHHHHHHHH----HHHHHHH------HHHHHHHHHH---------HHHHHHHHHHHH-----HEEEEE------HHHHHHH---------HHHHHHHHHHH---------------HHHHHHHHH---------HHHHHHHHHHHHHH---HHHHHHHHHHHH-- Symplekin_1N sspred --------------HHHHHHHHH--------HHHHHHHHHHHH-----HHHHHHHHHHHHHHH-----HHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHH-------------------EE----------HHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHH-HHHHHHHHHHHHHH---------HHHHHHHHHHHHHHHHHHH--------HHHHHHHHHHHHHHHHHHHHHH---HHHH--------HHHHHH-------------------------HH---------HH---------HHHHHHHHHHHHH----HHHHHHHHH------------HHHH--------------------------------------HH------------------------HHHH--------------HHHHHHH-HHHH-----------HHHHHHHHHHHHHHHHHH---------HHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHH-----HHHHHHHHHH-----HHHHHHHHHH-----HHHHHHHHHHHHHH-----HHHHHHHHHHHHH---HHHHHHHHHHHHHH------HHHHHHHHHHHHHHHH-------------------HHHHHHHHHHHHHHHHH-----HHHHHHHHHHH---HHHHHHHHHHHHHHHHH-----HHHHHHHH-----HHHHHHHHHHHHH------HHHHHHHHHHHHH-----EEEEHH-----HHHHHHH--------HHHHHHHHHHHH---------------HHHHHHHHH--------HHHHHHHHHHHH-------HHHHHHHHHHH-- Symplekin_1N netsurfp ---------------------HH---------HHHHHHHHHHHH----HHHHHHHHHHHHHHHH--HHHHHHHHH-H-HHH----HHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHH-----H-HHHHHHHHHHHHHHHHHHH-----HHHHHEEEEEEEEEEHH------------------E---------E-HHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHH-HHHHHHHHHHHHHHH---------HHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHH---HHHHHHHHHHHHH-------------HHHHH---------------------HHHH-----------HHH-------HHHHHHHHHHHH-----H-HHHHH------------------HHHH-----------------------------------HHH-----------------------------------------HHHH-----H-----------HHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHH---------HHHHHHHHHHHHHH---H-HHHHEEEHHHH----HHHHHHHHHHH--HHHHHHHHHHHHHHHHH----HHHHHHHHHHHHH---HHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHH----HHHH-------------HHHHHHHHHHHHHHHH--HHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHH----HHHHHHHHH-----HHHHHHHHHHHHHH----HHHHHHHHHHHHH-----EEEEEEE----HHHHHHHHHHHHH--HHHHHHHHHHHHH--------------HHHHHEHHHH-------HHHHHHHHHHHHHH-----HHHHHHHHHHHH- Symplekin_1N soprano --------------HHHH-------------HHHHHHHHHHHHH----HHHHHHHHHHHHHHH---HHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHEEE------------------------------HHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHH-HHHHHHHHHHHHHH--------HHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHH---HHHHHHHH----------------HHHHHH-----------------------------------HHHHH------HHHHHHHHHHHHH----H-HHHHHHH----------HHHHHHHHHHHH--------------------------------HH---------------------------------------------H-----HHHHH---------HHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHH------HHHHHHHHHH-----HHHHHHHHHHH----HHHHHHHHHHHHHH-----HHHHHHHHHHHH----HHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHH------HH--------------HHHHHHHHHHHHHH----HHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHH-----HHHHHHHHH----HHHHHHHHHHHHH------HHHHHHHHHHHHH-----EEEEE------HHHHHHHHHHHH---HHHHHHHHHHHH---------------HHHHHHHHH--------HHHHHHHHHHHHH------HHHHHHHHHHHH- Symplekin_1N consensus CNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKLVIVNGDDPLSRQAQENATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAIAHPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLTVFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMPDFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIRIMNSDENKMQEEEEVVDKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKIIITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALERELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLMEAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGMEIPTNIPGLGAAGPTGMFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDASGFSPGYSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPTSPSYSPTSPSYSPTSPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPASPKYTPTSPSYSPSSPEYTPTSPKYSPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTSPKYSPTSPTYSPTSPKYSPTSPTYSPTSPKGSTYSPTSPGYSPTSPTYSLTSPAISPDDSDEEN RPB1_1C sequence --HHHHHHHHHHH------------HHHHHHHHHHHHHH--EE-------HHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHH-----HHHHHHHH-----------------------------HHHHHHH--------EEEEEE----HHHHHHHHHHHHHH---------EEEEEEE---------HHHHHHHHHHH------------EEEEEE--HHHHHH----HHHHHHHHHHH------EEE--------EEEEEEE-----HHHHHHHHH----HHHHHHHHHH-----EEE-------EEEEE--------EEEE----------EEEEEEEE--HHHHH-------------HHHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHH------EEEE-----------------HHHHHHHHHHHHH-----------HHHH----------EEEEE--HHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RPB1_1C psipred --HHHHHHHHHHH------------HHHHHHHHHHHH--EEEEE----HHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHH------HHHHHHHH------------HHHH-------EE---HHHHHHHHHH------EEEEEE-------HHHHHHHHHHHH---HHH--EEEEEEE-------EE---HHHHHHHH------------EEEEEEE-HHH-------HHHHHHHHHHH----EEEEEE-----EEEEEEEEEE---------HHH-----HHHHHHHHHHHHHHHHH------EEEEEEEE-------EEEEE----EEEEEEEEEE----HHHHHH--------------HHHHHHHH-HHHHHHHHHHHHHHHHH-------HHHHHHHHHHHH---EEEEEE------------EE--HHHHHHHHHHHHHH----------EEEEE---------EEEEEE-HHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RPB1_1C prof --HHHHHHHHHH-------------HHHHHHHHHHHH---EEE----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHH-----------------------------------------HHHHHHHHH-------EEEE--------HHHHHHHHHHHHHHHH---EEEEEEEE--------HHHHHHHHHHHH------------EEEEEEE-HHHHH-----HHHHHHHHHHH----EEEEEE------EEEEEEE-------------------HHHHHHHHHHHHH------------EEEEEE-----EEEEEE-----EE---EEEEEE--HHHHHH---------EEE---EEEEEE---HHHHHHHHHHHHHHHH------HHHHHHHHHHHHHH----EEEEEEEEEE------EE---HHHHHHHHHHHHHHH-------HHHHHH----------EEEEEE-HHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RPB1_1C jnet --HHHHHHHHHHH------------HHHHHHHHHHHHH--EEE------HHHHHHHHHHHHHHHHHHH----HHHHH----HHHHHHHHHHHHHHHHHH--------EEEEE-----------------------EE-----HHHHHHE--------EEEEEE-------HHHHHHHHHHHHHH-HHHHHHHEEEEE------EEEEHHHHHHHHHH------HHH---EEEEEEE-HHHHHH----HHHHHHHHHHH-----EEEE--------EEEEEEE----------HHH-----HHHHHHHHHHHH---EEE------EEEEEE---------EEE----------EEEEEE----HHHHH--------EE----EEHHHHHH-HHHHHHHHHHHHHHHHH-------HHHHHHHHHHHH----E---------------EEEE----HHHHHHHHHHH----------HHHE------------EEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RPB1_1C sable --HHHHHHHHHHHH-----------HHHHHHHHHHHHHH-EEE----HH-HHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHH----HHHHHHHHHH--------EE--HHH--------------HHHHHHHH-------EEEEE---H---HHHHHHHHHHHH---HHHHH--EEEEE-------EEH--HHHHHHHH------H-----EEEEEEE-HHHHH-----HHHHHHHHHHH----EEEEEE------EEEEEEEE----------H--------HHHHHHHHHHHHHH---------EEEEEE-------EEEEE-----E----EEEEE---HHHHHHH--------E-----HHHHHHHHHHHHHHHHHHHHHHHHHH-----H-HHHHHHHHHHHHH---EHEEE----------HHHH--HHHHHHHHHHHHHH---------HHHHE-----------EEEEE-HHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RPB1_1C sspro4 -HHHHHHHHHHHHH-----------HHHHHHHHHHHHHHHHEE-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHH------EEEEEE-----------------------EE----HHHHHHHHHH------EEEEEE-------HHHHHHHHHHHHHHHHHHHHHHEEEEE-----EEEEHHHHHHHHHHH------HHH---EEEEEE--HHHHHHH---HHHHHHHHHHH-----EEEE--------EEEEEE---------HHH-------HHHHHHHHHHHH--EEEEEE----EEEEEE---------EEE----------EEEEEEE--HHHHHHH-------EEE--HHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHH---EEEEE-----------HHHHHHHHHHHHHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RPB1_1C psspred --HHHHHHHHHHHH-----------HHHHHHHHHHHHHHH-E--------HHHHHHHHHHHHHHHHHHH-HHHHHHHH---HHHHHHHHHHHHHHHHHH------HHHHHHH-----------------------------HHHHHHHHHH------EEEEEE-------HHHHHHHHHHHHHHHHHHHHHHEEEEE-------E----HHHHHHHHH-----H-H---EEEEEEE-HHHHHHH---HHHHHHHHHHHH----EEEE------EEEEEEEE---------HHHHHHHHH-HHHHHHHHHHHH---EEE-------EEEEE-------EEEEE-----EEEE-EEEEEEE---HHHHHH-------------HHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHH---E-EE-----------HHHHHHHHHHHHHHHHHHHH---------EEEEEE----------EEEEE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RPB1_1C spineX --EEEEEE----E------------HHHHHHHHHHHHHH-EEE-------HHHHHHHHHHHHHHHHHH----EEEEEE---HHHHHHHHHHHHHHHHHH------EEEEE---------------------------------HHHHE---------EEEEEE-------HHHHHHHHHH---EEEEEEEEEEEEEE-----EEEEEE--EEEEEEEE------------EEEEE--HHHHH-----HHHHHHHHHH------EEEE-------EEEEEEEE--------EEEEE-----HHHHHHHHHHHH---EEE-----EEEEEEE-------EEEEEE------EEEEEEEEE---EHHHH---------EEEE--EEEEEEE--HHHHHHHHHHHHHHHHHH------HHHHHE----------EEEEE----------HHHHH-HHHHHHHHHHHHH-------------EE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RPB1_1C raptorxss --HHHHHHHHHHHH-----------HHHHHHHHHHHHHH---------HHHHHHHHHHHHHHHHHHHH--HHHHHHH----HHHHHHHHHHHHHHHHH-------EEEEEEEE------------HHH-------------HHHHHHHH--------EEEEEE-------HHHHHHHHHHH-HHHHHHHEEEEEEEEE-----------HHHHHHHH------HHH---EEEEEE--HHHHHH----HHHHHHHHHHH----EEEEEE------EEEEEEEE----------HH------HHHHHHHHHHHHHH--EEE----E-EEEEE--------EEEE-----------EEEEE----HHHHH----E----EEE--HHHHHHHH-HHHHHHHHHHHHHHHHHH------HHHHHHHHHHHH---EEEEEE----------HHHHHHHHHHHHHHHHHHHH--EE------HHHH---EEE----EEEEE---HH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RPB1_1C SPARROW --HHHHHHHHHHHH-----------HHHHHHHHHHHHHH--------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHH-------------------------------------H------HHHHHHHH------EEEEEE-------HHHHHHHHHHHH-EEHHHHEEEEEEEE------EEEE--HHHHHHHH------HHH---EEEEEEE-HHHHHH----HHHHHHHHHHH-----EEEE-------EEEEEEE-------------------HHHHHHHHHHHH----EEEEE--EEEEEEE--------EEEE----------EEEEEE----HHHHH---------EE---HHHHHHHH-HHHHHHHHHHHHHHHHHH------HHHHHHHHHHHH----EE-E-----------HHHHHHHHHHHHHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RPB1_1C *SPARROW --EEEHHHHHHHHEEE---------HHHHHHHHHHHHHHHEEEE------HHHHHHHHHHHHHHHHHHH-HHHHHHHHH--HHHHHHHHHHHHHHHHHH----HHHHHHHHHHHH-----EEEEEEEEEE-----EEEEE---HHHHHHHHH-----EEEEEE-HHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEE-----EEEE---HHHHHHHHH-----HHH--HHHHHEEE-HHHHH-HHHHHHHHHHHHHHHHH--EEEEEE----HHEEEEEEEE---------HHHHHHHHHHHHHHHHHHHHHHHEEEEEE--H-HEEEEE-------EEEEE-----EEEEEEEEE-----EEHHHHE-----EEEEEE--HHHHHHHH-HHHHHHHHHHHHHHHEEE---EEEHHHHHHHHHHHHH---EEEEE-----------EEE--HHHHHHHHHHHHHHH---H-----HHHHH----------EEEEE-HHHHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHH RPB1_1C HMMSTR --HHHHHHHHH--------------HHHHHHHHHHHH----------HHHHHHHHH--HHHHHHHHH---HHHHHH-----HHHHHHHHHHHHHHHH--E------HHHHHHHHHHHHHH--------------------HHHHHHHH----------EEEEE-------HHHHHHHHHH---EEHHH-EEEEEEE---------------HHHH---------------EEEEEE-----------HHHHHHHHHH------EEEE--------EEEEE----------------------HHHHHHHHHHH---EEE-------EEEEEE---EEEEEEE-----EEEEEEEEEEE----HHHH-----E-----E---HHHHHHH--HHHHHHHHHHHHHHHHH-------HHHHHHHHHHH--------------------HHHHH-----HHHHHHHHHH---E----HHHHHH-------HHH--EEE---HHHHHH--------HHHHHH-------------------------------------HHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RPB1_1C porter --HHHHHHHHHHHH-----------HHHHHHHHHHHHHHHEEE------HHHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHH-----HHHEHHHHH-----HHHHHHHH---------------HHHHHHHH--------EEEEEE--HHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEE-----EEEEEE-HHHHHHHHH-----------EEEEEEH-HHHHHH----HHHHHHHHHH-----EEEE--------EEEEEEEE----HHH-HHHHHH----HHHHHHHHHHHHHH--EE------EEEEEE------EEEEEE-----EEEEEEEEEEE--H-HHHHH--------E----HHHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHH----EEEEEEE---------------HHHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RPB1_1C spine HHHHHHHH----EEEE-----------EEE--------EEEEE--------------EEEEEEE-------HHHHHHH------HHHHH----------------HHHHHHHH--------EEE--EE--------EEE--------EEE--------EEEEEE------HHHHHHHHHH------EEE----EEEE------EEEE----EEEEEE--------EE---EEEEE----------HHHHHHHHHH---------EEE------EEEEEEEEE--------HHHHHHH------EEEEE-----------------EEEEE--------EEEEE-----HHHHHHH------EEEEEE----------------EEEEE--HHHHHHHHHHHHEEEEEE--------EEEEEE--------EEEEE-----------------HHHHHHHHHHH---------------EE----------EEEEE--------EE---------------EEE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EE---------------------------------------------------EEE-------------- RPB1_1C nnssp --HHHHHHHHHHHHHH---------HHHHHHHHHHH---EEEEE---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHH------------HHHEEEEHHHHHHHHHH-------EEEEEEE---HHHHHHHHHHHHHHH-----------EEEEE-----EEEEE--EEEEEE-------HHH--HHHHHHHHHHHH-------HHHHHHHH-------EEEEE----HHHHHHHHHHH--HHHHHHHHHHHHHH----EEEEEEE--------HHHHHHHHHHH----------EEEEEE--EEEEEEEEEEEEE---HHHHHHH------------EEEEEE---HHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHH---HHHHHHHHHHH--------HHHHHH----------HHHHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RPB1_1C pssfinder HHHHHEEEEEEEEE----------EEEEEE--------EEEEE--------------EEEEEEEE--EE--------EEE-HHHHHHHH--------HHHH---EE-EEEE----------EEEEEEEEE----EEEEEEE------EEEEE------EEEEEE------------EEEEEE---EEEE--EEEEEE-----EEEEEE---EEEE---------------EEE----HHHH----EEHHHHHHH---------EEEEE--HHHEEEEEEEEE------EEE---EEE-----EEEEEEEEE--------EE----EEEEEE------EEEEEE-----HHHHHH------------EE-------EEE----EEEEEHHHHHHHHHHH---EEEEEEE-------HHHEEEEEEEEE--EEEEEEEE---EEE---EEEEE-HHHHHHHHHHH---------------EEE-----------EE-------------EE--EEE-----EEEEEE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEE-------------- RPB1_1C sspal HHHHHHHHHHHH--------------EEEHHHHHHHHHHHEEEE----HHHHHHHHHHHHHH--HHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHH----HHHHHHHHH---------EEEEEEE-------EEEEE-HHHHHHHHHH-----EEEEEEE-HHHHHHHHHH------------------EEEE------EEEE----EEEEEEE-----------HHHHHHHHH--HHHHHHHHHHHHHHHHH-----------HHHHHHEEEEEEEEHHHHHHHHHHHHHHHHH--HHHHHHHHH----HHHHHHHHHHHH-------------EEEEHHHHHHHHHHHHHH---EEEEEEE--------------EEEEEEEEE-HHHHHHHHH-EEEEEEE------HHHHHHHHH--------------------------HHHHHHHHHHHHHHH-----------HHHHHHHHH------HHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEEE-----------EEEEE------------- RPB1_1C ssp -------HHHH-----------------HHHHHHHHH--------------------------------------------HHHHHHHHHHHHHHHHH------------------------------------------------------------------------HHHHHHHHH-------------------------------HHHH-----------------------------------HHHHHHH----------------------------------------------HHHHHHHHH----------------------------------------------------HH----------------HHHHH-------HHHHHHHHHHHH---------------------------------------------------HHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ RPB1_1C sspred --HHHHHHHHHHH------------HHHHHHHHHHHHHHHH--------HHHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHH-------------------------------------------HHHHHH----------EEEEE-------HHHHHHHHHHHHHHHHHHHEEEEEEEEE-----EEEEHHHHHHHHHH------------EEEEEEE-HHHHHH----HHHHHHHHHHH----EEEEEE------EEEEEEE----------H--------HHHHHHHHHHHH----EEE-----EEEEEEE-------EEE-----------EEEEEEE---HHHHH--------EEE---HHHHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHH-----EEEE------------EEEHHHHHHHHHHHHHHHH------------EEE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ RPB1_1C netsurfp --HHHHHHHHHHHH-----------HHHHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHH-------EEEEE------------------------EH-----H-EHHHHH-------EEEEE-------HHHHHHHHHHHHHHHH-HHH----EHH--------HHHHHHHHHHHHHH----HH----EEEEEEE-HHHHHHH---HHHHHHHHHHH------EEE--------EEEEEEE------------------HHHHHHHHHHHH----EEEE----EEEEEEE-------EEEE----------EEEEEE----HHHHHH------EEEEE--HHHHE-HH-HHHHHHHHHHHHHHHHHH--------EEEEEEEEHHH---E--------------HHHHHHHHHHHHHHHHHHHH----------EEEEE---------EEEEEE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RPB1_1C soprano --HHHHHHHHHHH------------HHHHHHHHHHHHHH-EEE------HHHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHH-------HHHHHH------------------------------HHHHHHHH-------EEEEEE-------HHHHHHHHHHHH-H-HHHH-EEEEEEE------EEEE--HHHHHHHH------------EEEEEEE-HHHHHH----HHHHHHHHHHH-----EEEE-------EEEEEEEE----------HHH-----HHHHHHHHHHHH----EE------EEEEEE--------EEEE----------EEEEEE----HHHHH--------EEE---HHHHHHHH-HHHHHHHHHHHHHHHHHH------HHHHHHHHHHHH----EEEE------------HHHH-HHHHHHHHHHHHHH----------HHHE-----------EEEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RPB1_1C consensus MSCVHYKFSSKLNYDTVTFDGLHISLCDLKKQIMGREKLKAADCDLQITNAQTKEEYTDDNALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPAMATTKAIDDSSASISLAQLTKTANLAEANASEEDKIKAMMSQSGHEYDPINYMKKPLGPPPPSYTCFRCGKPGHYIKNCPTNGDKNFESGPRIKKSTGIPRSFMMEVKDPNMKGAMLTNTGKYAIPTIDAEAYAIGKKEKPPFLPEEPSSSSEEDDPIPDELLCLICKDIMTDAVVIPCCGNSYCDECIRTALLESDEHTCPTCHQNDVSPDALIANKFLRQAVNNFKNETGYTKRLRKQLPPPPPPIPPPRPLIQRNLQPLMRSPISRQQDPLMIPVTSSSTHPAPSISSLTSNQSSLAPPVSGNPSSAPAPVPDITATVSISVHSEKSDGPFRDSDNKILPAAALASEHSKGTSSIAITALMEEKGYQVPVLGTPSLLGQSLLHGQLIPTTGPVRINTARPGGGRPGWEHSNKLGYLVSPPQQIRRGERSCYRSINRGRHHSERSQRTQGPSLPATPVFVPVPPPPLYPPPPHTLPLPPGVPPPQFSPQFPPGQPPPAGYSVPPPGFPPAPANLSTPWVSSGVQTAHSNTIPTTQAPPLSREEFYREQRRLKEESKSPYSGSSYSRSSYTYSKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHGYHRSRSRSPPYRRYHSRSRSPQAFRGQSPNKRNVPQGETEREYFNRYREVPPPYDMKAYYGRSVDFRDPFEKERYREWERKYREWYEKYYKGYAAGAQPRPSANRENFSPERFLPLNIRNSPFTRGRREDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPP IKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQKVKSVTV RBBP6_2 sequence --EEEEEE-------EEEE------HHHHHHHHHHH---------EEEE-------------------EEEEEEE-----------EEE------------------HHHHHHHHHHHHHHHH---HHHHHHHHHHH--------------------------------------------------------------EE---------EE-----EEEE---HHHHHH--------------------------------------------------HHHHHHHHH-----------------------HHHHHHHHHHHHHH------------------------------------------------------------------------------------------------------------------------------HHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHH------------------------------------------------------------------------------------------------------------HHHHHH-----------------------------------------EEE--HHHHH----------------- RBBP6_2 psipred --EEEEEEE------EEEE---EE-HHHHHHHHHHHH--------EEEE-------------EE----EEEEEEE-----------EEE-------------------------------------HHHHHHHHHHHHH-------------------EEEEE------EEE-----------------------HHHHH---------EEEE----EEEEE--HHHHHHHHH----------------------------HHHH---------------HHHHHHHHH-----------------------HHHHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHH------------------ RBBP6_2 prof ---EEEEEE---------------HHHHHHHHHHHH--------EEEEE------------EEEE---EEEEEEE--------------------------------------------------HHHHHHHHHHH----------------------EEEEE------EE----------------E----------EEEE-------EEE-----EEEE---HHHHHHHHHH-----------------------------------EE----------HHHHHHH------------------------HHHHHHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEEE------------------------- RBBP6_2 jnet --EEEEEE-------EEEE---EEEHHHHHHHHHHH--------EEEEEE------------EE----EEEEEE----------------------------------------------------HHHHHHHHHH-----------------------EEEE--------------------------------HHHHH---------EEE-----EEEE----HHHHHH-------------------------------HHHHH---EE-------HHHHHHHHH------------------------HHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------EEE--------------------EEE------------------------- RBBP6_2 sable -EEEEEEE----EEEEEEEE-EEE-HHHHHHHHHHHH------EEEEEEE----EEE----EEEE--EEEEEEEEEE-------------------------------------------------HHHHHHHHHHHHHHHHH----------------EE------------------------------------------------EEE----EEEEE---HHHHHHHHHHHHHHHHHHHH--------------------------E----------HHHHHHH-------------------------HHHHHHHHHHHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEE------------------------------------------------ RBBP6_2 proteus --EEEEEE-------EEEE------HHHHHHHHHHHH---------EE-----HHH------------EEEEEE-----------HHHH--------------------HHHH----HHHHH----HHHHHHHHHHH--------HHH-----------EEE-------EEE-----------------------HHH-EE---------E------EEEE---HHHHHHH-H------HH-------------HH----HHHHH----EE---------HHHHHHHHH----------------H-H----HHHHHHHHHHHHH----------------------HHHHH------------------E-------------------------------------------EE---E---------E-------HHHH----------EEEEEH-------E--E--------------------------EE------------------------EEE---EEEEE------EEEEE------------------------------------------------------------------------EE---------------------HHHH-HH-HHHHHH--------------HEE----------EEEEE--------------------------------------------------------------------------HHHH---------HHHEEEEEEE-------HH----HHH-------------------------------HHH--------------------------------------------------------------------------------------HHH-------------------EEEE------------------EEEE-------------------------- RBBP6_2 sspro4 --EEEEEEE------EEEE------HHHHHHHHHHHH-------EEEEE-------------EE----EEEEEEE---------------------------------------------------HHHHHHHHHHH-------------------------------------------------------------------------EE-----EEEE---HHHHHHHHH---------------------HHHH-----------EE---------HHHHHHHHH------------------------HHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_2 psspred -EEEEEEE-------EEEE------HHHHHHHHHHHH-------EEEEEE------E----------EEEEEEEE----------EEE----------------------HHHHHHHHHHHHH---HHHHHHHHHHHH----------------------------------------------------------HH-EE--------EEEE---EEEEEE--HHHHHHHHH-------------------------------------E---------HHHHHHHHHH---------------HHH----HHHHHHHHHHHHHH--HH-------------------------------------------------------------------------------------------------------------HH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHH-------------------------------------------------------------------------HHHHHHH------------HHHHHHHH---------HHHHHHHH--------------------------------------------HHHHHHHH--HH---------- RBBP6_2 spineX --EEEEE--------EEEE------HHHHHHHHH-H---------EEEE-----EEE-----E-----EEEEEE-----------EEEE------------------------------HHHH---HHHHHHHHHH-----------------------EE----------------------------------HHH------------EEE----EEEEE--HHHHHH------------------------HHH------------EEE--------HHHHHHHHHH----E-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_2 raptorxss -EEEEEEE------EEEEE------HHHHHHHHHHH--------EEEEE------------EEE----EEEEE--------------E-------------------------------HHH----HHHHHHHHHHH----------------------EEE-------EEE---------------E-------HHHEEE--------EEEE----EEEE---HHHHHHHHHHH-------------HH---------HH---HH---EE---------HHHHHHHH------E----------H------HHHHHHHHHHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHH---------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHH----------------------------------------------------------------H----------H-HH------------HHHHH--------------HHH---HH---------------EEEE-------------------------HHHHHH---------HHH---- RBBP6_2 SPARROW --EEEEEE-------EEEE----E-HHHHHHHHHHH--------EEEEE-------E-----E-----EEEEE-------------E---------------------------------------HHHHHHHHHHH-------H--------------------------------------------------HHH-----------EEE-----EEEE---HHHHHHHHHH-----------------------------HH---------------HHHHHHHHHH----E-----------------HHHHHHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_2 *SPARROW --EEEEEEEE-----EEEEE--EEEEHHHHHHHHHHHH-----EEEEEE------EE-----E-----EEEEEE------------EEEE--------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--HH----------------H--H---EEEE------------HHHHHH-----HHHHHEE-------EEE-----EEEE---HHHHHHHHHHHHHHHHHH----HH------HHHH-HHHHHHHH---EE---HHHHHHHHHHHHHHHH-----HH-H-----H-H-E-HHHHHHHHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHH----------------------------------------------------------------------------------------HHHH---------------------------HHHHHHHHHHHHHHHHHHHHH------------------------------------------------------------------------------------------HHHHH-----------HHHHHHHHH-------HH-----EEE------------------EEEEE---HHHHHH--------HHHHHHHH RBBP6_2 HMMSTR -EEEEEEE-----EEEEEE---EEEHHHHHHHHHHHH------EEEEEEE-----EE-----EEE----EEEEEEE----------EEE--------------------E----------------HHHHHHHHHH----------------------------------HHH--HHH---------------------------------------EEE----HHHHHHH-----------------------HHH------------EE------EE---HHHHHHHH----------------------HHHHHHHHHHHHH----HHHH--------------HHHHH------------------------------------------------------------EEEEEEEE-----------------HHHHHHHH------HHHHHHHHHH------------------------------EE--------------------E-----H---------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHH-----------------------------------------------------------------------------------------H----------------HHHHHHHH---------HHH---------HHHHHHHHHHHHHHHHHHHHHHHHHH--------------------------------------------------------------------------------------------------------HHHHHH-----------------EEE------------------------------------------------ RBBP6_2 porter ----EEEE-------EEEE---EEEEHHHHHHHHHHHHHHHH-HHHHH--HHHHHH-------------EEEEEE---------EEEEEE----HHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----------------------EEEE------EEEE-----------------------EEEEE--------EEE----------HHHHHHHH------------------------HHHHHHHH------EEEEE--------HHHHHHHH-----------------HHHHHHHHHHHHHH--------HHHHH---------------HHHHHH---------------EEEE---------------------------------------EEEEEEEEEE-------------HHHHHHHHHH------HHHHHHHHHH---EEEE------HHHHH-----------EEEEE----------------EEEE------------EEEE----------------------------------------------------------------------------------------------------------HHHHHHHHHHHHH--------------EEEEEE-----EEEEE--EEEE-----------------------------------------------------------------------HHHHHH------------------------HHHHHHHHHHHHHHHHHHHHHHH------------------------------------EEEE-------------------------------------------------HHHHHHH------------HHHHH---------------EEEE-------------------EEEEE--HHHHHHH--------------- RBBP6_2 cdm EEEEEEEE-----EEEEEE---EEEHHHHHHHHHHHH------EEEEEEE-----EE-----EEE----EEEEEEE--------EEEEEE----HHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------------------------------HHH--HHH-------------------------------EEE----------HHHHHHHH------------------------HHHH-----------EE------EE-HHHHHHHHHH-------------------EE-HHHHHHHHHHHHHH---HHHH---------------HHHHHH---------------EEEE---------------------------------------EEEEEEEEEE-------------HHHHHHHHHH------HHHHHHHHHH---EEEE------HHHHH-----------EEEEE----------------EEEE------------EEEE----------------------------------------------------------------------------------------------------------HHHHHHHHHHHHH--------------EEEEEE-----EEEEE--EEEE-----------------------------------------------------------------------HHHHHH------------------------HHHHHHHHHHHHHHHHHHHHHHH------------------------------------EEEE-------------------------------------------------HHHHHHH------------HHHHH---------------EEEE-------------------EEEEE--HHHHHHH--------------- RBBP6_2 fdm EEEEEEEE-----EEEEEE---EEEHHHHHHHHHHHH------EEEEEEE-----EE-----EEE----EEEEEEE-----EEEEEEEHHH-------------------------------------------------------------------------------HHH--HHH----------------------------HH-HHHHHHHHHHHHHH-HHHHHH----------HHH--HHHHHHHHH---------------EE------EE-HHHHHHHHHH-------------------EE-HHHHHHHHHHHHHH-----------------------------------------------------------------------------------------EEEEE-----HHHHHHHHHHH----EEEEEE-HHHHHHHHHHH---------EEE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEEE--------EEEEE-----------EEE----------------------------------------------------------------------------------------------------------------------- RBBP6_2 gor -EEEEEEEE------EEEE----EEHHHHHHHHHHH---------EEEE----HHH------------EEEEEEE----------EEEE---------------------HHHHHHHH-HHH----HHHHHHHHHH-----------------------EEEE------EE------------------------HHHHEE--------EEE-----EE-----HHHHHHH-------------------------EE----HHHH----E------HHHHHHHHHHHH-----E-----------------HHHHHHHHHHHH----HHHHH------------------------------------EE--------------------------------------------EEE-------------------HHHHH----------EHHHHHHHHH----------------------------EE-------------------------HHHHH------------------HHHHH----------E---------------------------------------------------------------------------------HHHHHH------------------------------------------------------------------------------------------------HHH---------------HHHHHH--------HHHHH----------HHHHHHHHHHHHHHHHHHHHHH------------HHH----HHH----------------HHH----------------HHH--------------HHHH-------------H-HHH------------HHHHHH-H--------------EEEEE------------------EEEE---HHHHHH---------------- RBBP6_2 spine --EEEEE---------EE----EEEE-------------------EEE---------------------EEEEEE----------EEEEE--------------------HHHHHHHHHHHHH------HHHHHHH------------------------EE----------------------------------EEEEE---------EEE---------------------------------------------EEE-------EEEEE-----------HHHHH------------------HHHHHHHHHHHHH------------------------------------------------EEEE------------------------------------------EEEEEE------------------HHHHH--------EEEEHHHHH------EE-----------------------EE-------------------EEE----------------------------------------EE--------------------------------------------------------------------------------HHHHHHHHHHHH----------------EEE---------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------EEEE------------------EEEEE------------------------ RBBP6_2 nnssp ---------------EEEE--EEEEHHHHHHHHHHHHHHHH----EEEE-------------------EEEEEE------------EEEEE--HHHHHHHHHH-------HHHHHHHHHHHHH---HHHHHHHHHHH----------------------------------------------------------HHHHHHH------EEEEE-----------HHHHH-------------------------HHHHHHHHHHH----EEEE-------HHHHHHHHHH---------------HHHHHHHHHHHHHHHH--------HHHHHH---------------------------------EEEEE--------------------------------------EEEEEEEEEEE---------------HHHHHHHHH-----HHHHHHHHHHH---------HHHHHHHHHH---------EEEEEE-------------------------------EEEEEE--------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHH--------------EEEEE---------------------------------------------------------------------------------------HHHHHHH----------------------HHHHHHHHHHHHHHHHHHHH---------------------HHH--------------------------------------------------------------------------------------HHHHHHHHH-------------EEEEEE------------------------HHHHHHH--------------- RBBP6_2 pssfinder ---EEEEE-EEEE---------EE------EEE-------EEE--EEEEE-EEEHHHH---------EEEEEEEEEE-------EEEEEE--------------------HHHHHHHH-HHHH---HHHHHHHHHH-----------------------EEEE----------------------------------EEEEEE-------------EEEEEE-HHHH-----------------------------EEEEE-----EEEEEEE-----HHHHHHHEEEE--------------------HHHHHHHHHHHHH------HHH--------------------HHHH--------------EEEE------------EE--------------------------EEEEEE-------------------HHHHH--------HHHHHHHHHH-----------EE--EE----EE------EEEE-------------------------------HHHH-------------------------------------------------------------------------------------EE---------------------HHHHHHHHHHHH-------------------------------------------------------------------------------------------------------------HHHHHHH----------------EEE-----HHHHHHHHHHHHHHHHHH---------------------------------------------HHHHHH----------------------------------------------------------HHHHHHHH--------------EEEEEE--------------HHHHHH-------------------------- RBBP6_2 sspal --EEEEEEE----EEEEEEE-EEEEHHHHHHHHH-----------EEEE--------------------EEEEEEE---EEEEEEEEEEE----------------HHHHHHHHHH---HHHHHHHHHHHHHHHH-----------------------EEEEE--------------------------------EEEEEEEE------------------HHHHHHHHH------------------------HHHHHHHHH-----EEEE---------HHHHHHHHH----------------HHHHH-HHHHHHHHHHH----HHHHHHHHH------------HHHHHHHHHHH---------EEEEEEE------------------------------------EEEEEEEEEE-------------HHHHHHHHH------EEEHHHHHHHHH--EEEEEEE--------------------EEEE---------------EEEEEEE--------------------------------------EEEEE-------------------------------------EEEE--------------------------------------HHHHHHHHHHH----------------EEEE----------EEEEEEE-----------------------------------------------------------------------HHHHHHHHHH-----------------HHHHHHHHHHH--HHHHHHHHHH-------------------------------------------------------------------------------------------HHHHHHHHH---------HHHHH------------------EEEE------------------EEEEEEE---------------------- RBBP6_2 ssp ----------------------------HHHH----------------------------------------------------------------------------------------------HHHHHHH----------------------------------------------------------------------------------------------HH-----------------------------------------------------HHHH---------------------------HHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_2 sspred --EEEEEE-------EEEE------HHHHHHHHHHH--------EEEEE-------------------EEEEEEE----------EEEE-------------------------------------HHHHHHHHHHHH-----------------------------------------------------------H-----------EEE-----EEEE---HHHHHHHHHHH---------------------------HHHH--------------HHHHHHHHH-----------------------HHHHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_2 netsurfp --EEEEEE--------EE-------HHHHHHHHHHHH-------EEEEEE------------EE----EEEEEEE----------EEEE------------------------------HHH-----HHHHHHHHHHHHHH------------------EE--------------------------EE---------EE---------EEE-----EEEEE--HHHHHHHHHHHHHHHHHH--HHHHH--------------------EEE--------HHHHHHHHHH----E-----------------HHHHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHH------------------------------------------------------------------- RBBP6_2 soprano --EEEEEE-------EEEE---EE-HHHHHHHHHHHH-------EEEEE-------------E-----EEEEEEE-----------EEE------------------------------HHH----HHHHHHHHHHH----------------------EE------------------------------------H-E---------EEE-----EEEE---HHHHHHH--------------------------------------EE---------HHHHHHHHH-----------------------HHHHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHH----------------------------------------------------------------------------------------------------------------H--------------------EEE------------------------------------------------ RBBP6_2 consensus MSDSEKLNLDSIIGRLLEGSRVLTPHCAPVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPADKNKGKYGQFSGLNPGGRPITPPRNSAKAKK PP-1A_2 sequence --------HHHHHHHHH-------------------------HHHHHHHHHHHHHHHHH---EEEE---EEEE------HHHHHHHHHH---------EE----------HHHHHHHHHHHHH-----EEEE--------------HHHHHHHH--HHHHHHHHHH-----HHEEE---EEEEE---------HHHHH--------------HHH--------------------EE--HHHHHHHHHH----EEEEE-------HH------EEEEE------------EEEEEE-----EEEEEE---------------------------------- PP-1A_2 psipred --------HHHHHHHHHHH------------------EEE--HHHHHHHHHHHHHHHH----EEE-----EEEE----HHHHHHHHHHH--------EEEE----------HHHHHHHHHHH------EEEEE----HHHHHHHH--HHHHHHHH-HHHHHHHHHHH----EEEEE---EEEE----------HHHHHHH-----------HHHH------------------EEEEE-HHHHHHHHHH-----EEHHHHHHHHHHHHHH--EEEEEEE------------EEEEE----EEEEEEE---------------------------------- PP-1A_2 prof -------HHHHHHHHHHHHH----------------------HHHHHHHHHHHHHHHHH---EEE----EEE------HHHHHHHHHHH--------EEEE--------HHHHHHHHHHHHHHH----EEEEE---------EEEEEHHHHHHHHHHHHHHHHHHHHHH--HHHHH---EEEE-------HHHHHHHH---------------EEE-----------------EEEEE--HHHHHHHH----EEEHHHHHHHHHHHHHH----EEEEEE------------HHHHHHHHHHHHHHH----------------------------------- PP-1A_2 jnet --------HHHHHHHHHH------------------------HHHHHHHHHHHHHHHH----EEEE---EEEE------HHHHHHHHHH--------EEEE---------HHHHHHHHHHHHH-----EEEE-----HHHHHHH---HHH------HHHHHHHHHHHH---HHHH----EEEE----------HHHHHH------------HHEE------------------EEEE--HHHHHHHHHH----EEEE-HHHHH--HHHH----EEEEE------------EEEEEE-----EEEEEE---------------------------------- PP-1A_2 sable --------HHHHHHHHHHHHHHHHHHHHH-------------HHHHHHHHHHHHHHHHH---EEEE---EEEE-E----HHHHHHHHHHH-------EEE----------HHHHHHHHHHHHHH----EEE-------HHHHHHH-HHHHHHHH--HHHHHHHHHHH-----EEEE---EEEE----------HHHHHH-----------HHHHHHH-EE------EEE------EEE-HHHHHHHHHHH---EEEE--------EEEE----EEEEE------------EEEEEE-----EEEEEE----H----------------------------- PP-1A_2 sspro4 --------HHHHHHHHHH--------HHHHHHH---------HHHHHHHHHHHHHHHHH---EEEE---EEEEE-----HHHHHHHHHH-------EEEEE---------HHHHHHHHHHHHHH---EEEEEE------HHHHHH-HHHHHHHHH-HHHHHHHHHHHHH--EEEEE---EEEEE---------HHHHHH-----------HHHHHH------------------EEEE-HHHHHHHHHHH---EEEEE-----H-HEEEE--EEEEEE-----------EEEEEEE-----EEEEEE---------------------------------- PP-1A_2 psspred --------HHHHHHHHHHH------------------E----HHHHHHHHHHHHHHHHH-----E----EEEE-----HHHHHHHHHHHH--------------------HHHHHHHHHHHHHH----EEE------HHHHHHHH-HHHHHHHHH-HHHHHHHHHHHHHH-HHHHHH-EEEEE----------HHHHHH------------H---------------------------HHHHHHHHHHH---EEEEHHHHHHH--------EEEEEEE-----------EEEEEEE---EEEEEE----------------------------------- PP-1A_2 spineX ----------HHHHE--------------EE-------EE--HHHHHHHHHHHHHHHH----EEEE----EEE------HHHHHHHHHH----------------------HHHHHHHHHHH-------EE-----------EE---HHHHHH---HHHHHHHHHHHHH--HHHH---EEEE-----------HHHHHH----------------E------------------EEEE-HHHHHHHHHH--HHHHHHHHHHHHHHHHHH----EEEEEE-----------EEEEEE----EEEEEEEE--------------------------------- PP-1A_2 raptorxss --------HHHHHHHHHH------------------------HHHHHHHHHHHHHHHH----EEEE---EEEE------HHHHHHHHHH--------EEE---EE-----HHHHHHHHHHHHHH----EEEEE-----HHH-EEEE-HHHHHH---HHHHHHHHHHH---EEEEEE--EEEEE----------HHHH--------------HH-EE------------E------EE--HHHHHHHHHH----EEEE--EE-H-HHEEE----EEEEEE----------EEEEEEE-----EEEEEEE--------------------------------- PP-1A_2 SPARROW --------HHHHHHHHHH------------------------HHHHHHHHHHHHHHH-----E-EE----EHHHH--H-HHHHHHHHH---------E-E-HH------HHHHHHHHHHHHHHH-----EEE-H----HHHH-----HHHHHHHH-HHHHHHHHHHHH----HHHH---EEEE----------HHHHHH-----------HH---------------------------HHHHHHHHHH----EEEE--HHHHHHHHHHH---EEEEEE----------EEEEEEE-----EEEEEEE---HHH--------------------------- PP-1A_2 *SPARROW -----HHHHHHHHHHHHHHHHHHHH--EEEE------EEE--HHHHHHHHHHHHHHHHH---HHHH---EEEEE-E----HHHHHHHHH--------EEEEE-EE-----HHHHHHHHHHHHHH----EEEEE--------EEE----HHHHHH--EEHHHHHEHEE----HHHHH--EEEEEE----HHHHHHHHHHHHHH---------HHHHHHH---H------------EEEEEHHHHHHHHHHH---EEEEHEEEEE---EEEEHH-EEEEEE------E------EEEE-HHHEEEEEEE----HHH--------------------------- PP-1A_2 HMMSTR --------HHHHHHHHH-----HHHHHHH-------------HHHHHHHHHHHHHHHHH---EEEE---EEEE-E----HHHHHHHHHHH-------EEE----------HHHHHHHHHHHHHH----EEE-------HHHHHHH-HHHHHHHH--HHHHHHHHHHH-----EEEE---EEEE----------HHHHH------------HHHHHHH-EE------EEE------EEE-HHHHHHHHHHH---EEEE--------EEEE----EEEEE----HHH-----EEEEEE-----EEEEEE----------EEE--------------------- PP-1A_2 porter ---------HHHHHHHH-----------HHHHHHHHHHH-HHHHHHHHHHHHHHHHHHH----------EEEE------HHHHHHHHH--------EEEE-----------HHHHHHHHHHHH-----EEEE------EEEEEEE--HHHHHHHH--HHHHHHH-------HHHHH--EEEEE---------HHHHHHHH------------EEEE------------------EEEE----HHHHHHH--HHHHHHHHHHHH--HHHH-----EEEE------------HHHHHH----EEEEEE----------------------------------- PP-1A_2 cdm --------HHHHHHHHH-HHHHHH--HHH-------------HHHHHHHHHHHHHHHHH---EEEE---EEEE------HHHHHHHHHHH-------EEE----------HHHHHHHHHHHHHH----EEE-------HHHH----HHHHHHHH--HHHHHHHHHHH-----EEEE---EEEE----------HHHHH------------HHHHHHH-EE------EEE------EEE-HHHHHHHHHHH---EEEE--------EEEE----EEEEE----HHH-----EEEEEE-----EEEEEE---------------------------------- PP-1A_2 fdm --------HHHHHHHHH-HHHHHH--HHH-------------HHHHHHHHHHHHHHHHH---EEEE---EEEE------HHHHHHHHHHH-------EEE----------HHHHHHHHHHHHHH----EEE-------HHHH----HHHHHHHH--HHHHHHHHHHH-----EEEE---EEEE----------HHHHH------------HHHHHHH-EE------EEE------EEE-HHHHHHHHHHH---EEEE--------EEEE----EEEEE----HHH-----EEEEEE-----EEEEEE---------------------------------- PP-1A_2 gor --------HHHHHHHHHH------------------------HHHHHHHHHHHHHHHHH---EEEE---EEEEEE----HHHHHHHHHH--------EEEE---------HHHHHHHHHHHHHH---EEEEE--------HH-H--HHHHHHHH--HHHHHHHHHHHHHHHHHHHH---EEEE----------HHHHHHH-----------EEEEEE------------------EE--HHHHHHHHHH----EEE---------EEEE---EEEEEEE-----------EEEEEE----EEEEEEE---------------------------------- PP-1A_2 spine ---------HHHHHHH---------------------------------------------------------------HHHHHHHHH----------EE-----------HHHHHHHHH--------EEEE--------HHHHH-----------HHHHHHH----------------EEE-----------HHHHHHHH---------------------------------EEE--HHHHHHHHHH----HHHHHHHHHHH---------EEEE---------------------------------------------------------------- PP-1A_2 nnssp --------HHHHHHHHH-------------------------HHHHHHHHHHHHHHHHH---EEEE---EEEE------HHHHHHHHHHH-------EEE----------HHHHHHHHHHHHHH----EEEE------HHHHHHH-HHHHHHHH--HHHHHHHHHHHHH---EEEE---EEEE----------HHHHHH-----------HHHHHHH-EE------EEE------EEE-HHHHHHHHHHH---EEEE--------EEEE----EEEE-------------EEEEEE-----EEEEEE---------------------------------- PP-1A_2 pssfinder --------HHHHHHHHH-------------------------HHHHHHHHHH-HHHH--HHHHHHHHH-----------HHHHHHHHHH---------------------HHHHHHHHHHH-------EEEE--------HHHHHHHHHHHHHHH-HHHHHHHH-------EEEEE---EEEE-------HHHHHHHHHHH--------------------------------------HHHHHHHHHH---HHHHHHHHHHHHHHHHH-----EEEE-------------------HHHHHHHHHH-----------------------------HHHHH PP-1A_2 sspal -------HHHHHHHHHHH--EEEE--------------EEEE----------------HHHHHHHHHH-EEEE------HHHHHHHHH-----------------HHHHHHHHEEEEEEEEEEEE----------------------HHHHHHHEEEEEEE----------HHHHHHHHH----------HHHHHHHHHHHH--------EEEEEEE----------------EEEEE-HHHHHHHHH----HHHHHHHHHHHH-HHHHHHHHHEEEE-----------------HHHHHHHHHHHHH--------------------------------- PP-1A_2 ssp --------HHHHHHHHHH------------------------HHHHHHHHHHHHHHHHH----EEE---EEEEE-----HHHHHHHHHHH------EEEEE----------HHHHHHHHHHHHHE--EEEEE---------HH----HHHHH----HHHHHHHHHHHHHH---EEE--EEEEEE------------HHH--------------------------------------E-HHHHHHHHHHH--EEEEE-----HH--EEE----EEEEE-----------HEEEEEE-----EEEEEE---------------------------------- PP-1A_2 sspred --------HHHHHHHHHH------------------------HHHHHHHHHHHHHHHH-----EEE----EEE------HHHHHHHHHH----------------------HHHHHHHHHHHH------EEE---------------HHHHHHH--HHHHHHHHHHHH---HHHH----EEEE----------HHHHH-----------------E-------------------E---HHHHHHHHHH----EEEEHHHHHHHHHHHH----EEEEEE-----------EEEEEE-----EEEEEE---------------------------------- PP-1A_2 netsurfp --------HHHHHHHHHHHH----------------------HHHHHHHHHHHHHHHHH---EEE----EEEEE-----HHHHHHHHHH--------EEEE---E-----EEEEEEEEEEE-HH----EEEEE-----H-H--HH-HHHHHHHH--HHHHHHHHHHHHH--EEEEE--EEEEE----------HHHHH-------------E-EEE-------------------EE--HHHHHHHHHHH---EEEEEEEEE----EEEE--EEEEEEE-----------EEEEEE-----EEEEEE----HH---------------------------- PP-1A_2 soprano --------HHHHHHHHHH------------------------HHHHHHHHHHHHHHHHH---EEEE---EEEE------HHHHHHHHHH--------EEE----------HHHHHHHHHHHHHH----EEEE------HHHHHH--HHHHHHHH--HHHHHHHHHHH----HHEEE---EEEE----------HHHHHH------------HHHHE-------------------EEE-HHHHHHHHHH----EEEE--HHHH--HEEE----EEEEE------------EEEEEE-----EEEEEE---------------------------------- PP-1A_2 consensus MSCVHYKFSSKLNYDTVTFDGLHISLCDLKKQIMGREKLKAADCDLQITNAQTKEEYTDDNALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPAMATTKAIDDSSASISLAQLTKTANLAEANASEEDKIKAMMSQSGHEYDPINYMKKPLGPPPPSYTCFRCGKPGHYIKNCPTNGDKNFESGPRIKKSTGIPRSFMMEVKDPNMKGAMLTNTGKYAIPTIDAEAYAIGKKEKPPFLPEEPSSSSEEDDPIPDELLCLICKDIMTDAVVIPCCGNSYCDECIRTALLESDEHTCPTCHQNDVSPDALIANKFLRQAVNNFKNETGYTKRLRKQLPPPPPPIPPPRPLIQRNLQPLMRSPISRQQDPLMIPVTSSSTHPAPSISSLTSNQSSLAPPVSGNPSSAPAPVPDITATVSISVHSEKSDGPFRDSDNKILPAAALASEHSKGTSSIAITALMEEKGYQVPVLGTPSLLGQSLLHGQLIPTTGPVRINTARPGGGRPGWEHSNKLGYLVSPPQQIRRGERSCYRSINRGRHHSERSQRTQGPSLPATPVFVPVPPPPLYPPPPHTLPLPPGVPPPQFSPQFPPGQPPPAGYSVPPPGFPPAPANLSTPWVSSGVQTAHSNTIPTTQAPPLSREEFYREQRRLKEEEKKKSKLDEFTNDFAKELMEYKKIQKERRRSFSRSKSPYSGSSYSRSSYTYSKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHGYHRSRSRSPPYRRYHSRSRSPQAFRGQSPNKRNVPQGETEREYFNRYREVPPPYDMKAYYGRSVDFRDPFEKERYREWERKYREWYEKYYKGYAAGAQPRPSANRENFSPERFLPLNIRNSPFTRGRREDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEP RBBP6_1N sequence --EEEEEE-------EEEE------HHHHHHHHHHH---------EEEE-------------------EEEEEEE-----------EEE------------------HHHHHHHHHHHHHHH----HHHHHHHHHHH--------------------------------------------------------------EE---------EE-----EEEE---HHHHHH--------------------------------------------------HHHHHHHHH-----------------------HHHHHHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHH----------HHHHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------HHHH--------------------------HHHHHHHHHHHHHHHHHHHHH--------------------------------------------------------------------------HH--------------------------------HHHHHH---------------------------------- RBBP6_1N psipred --EEEEEEE------EEEE---EE-HHHHHHHHHHHH--------EEEE-------------EE----EEEEEEE-----------EEE-------------------------------------HHHHHHHHHHHHH-------------------EEEEE------EEE-----------------------HHHHH---------EEEE----EEEEE--HHHHHHHHH----------------------------HHHHH--------------HHHHHHHHH-----------------------HHHHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_1N prof --EEEEEEE---------------HHHHHHHHHHHH--------EEEEE------------EEEE---EEEEEEE--------------------------------------------------HHHHHHHHHHH----------------------EEEEE------EE----------------EE-----------E--------EEE-----EEEEE--HHHHHHHHH------------------------------------EE----------HHHHHHHH-----------------------HHHHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_1N jnet --EEEEEE-------EEEE---EEEHHHHHHHHHHH-------EEEEEE-------------EE----EEEEEE----------------------------------------------------HHHHHHHHHH-----------------------EEEE--------------------------------HHHHH---------EEE-----EEEE----HHHHH--------------------------------HHHHH---EE-------HHHHHHHH-------------------------HHHHHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------EEE-------------- RBBP6_1N sable -EEEEEEE----EEEEEEEE-EEE-HHHHHHHHHHHH------EEEEEEE----EEE----EEEE--EEEEEEEEEE-------------------------------------------------HHHHHHHHHHHHHH---------------------------------------------------------------------EEE----EEEEE---HHHHHHHHHHHHHHHHHHHHH------------------------------------HHHHHH------E--------------------HHHHHHHHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHH------------------------------------------------------------------------------------------------------------------------------------------------------------ RBBP6_1N proteus --EEEEEE-------EEEE------HHHHHHHHHHHH---------EE-----HHH------------EEEEEE------------HHH--------------------HHHH----HHHHH----HHHHHHHHHHH-------HHHH-----------EEE-------EEE-----------------------HHH-EE---------E------EEEE---HHHHHHH-H------HH-------------HH----HHHHH----EE---------HHHHHHHHH----------------H------HHHHHHHHHHHHH----------------------HHHHH------------------E-------------------------------------------EE---E-----------------HHHH----------HHEEHH-------E--E-------------------------EEE------------------------EEE---EEEEE------EEEEE------------------------------------------------------------------------EE---------------------HHHH-----EE--HHH---------------HHHH-----------E-E----------------------------------------------------E----------------------------------------------------HHHH---------HHHEEEEEE--------HH----HHH-------------------------------HHH--------------------------------------------------------------------------------------HHHH------------------EEEE-------------- RBBP6_1N sspro4 --EEEEEEE------EEEE------HHHHHHHHHHHH-------EEEEE-------------EE----EEEEEE----------------------------------------------------HHHHHHHHHHH-------------------------------------------------------------------------EE-----EEEE---HHHHHHHHH-------------------------------------E---------HHHHHHHHHH---------------HHH----HHHHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_1N psspred -EEEEEEE-------EEEE------HHHHHHHHHHHH-------EEEEEE------E----E-----EEEEEEEE---------EEEE----------------------HHHHH-HHHHHHH---HHHHHHHHHHH--------------------------------E-------------------------HHHEEE--------EEEE---EEEEEE--HHHHHHHHH----------------------H-----------------------HHHHHHHHHHH---------------HHH----HHHHHHHHHHHHHH--HHH------------------------------------------------------------------------------------------------------------HH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHH--------HHHHHHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------HH----------HHHHHHHHHHHHHHHHHHHHH--------------------HHH-------------------------------------------------HHHHHHH-----------HHHHHHHHHH--HH-----HHHHHHH---------------EEEE-------------- RBBP6_1N spineX --EEEEE--------EEEE------HHHHHHHHH-H---------EEEE-------------E-----EEEEEE-----------EEEE-------------------------------H-----HHHHHHHHH---------------------------------------------------------------------------EE-----EEE----HHHHHH------------------------HH-------------EEE---------HHHHH-------------------HHH------HHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HH--------HHHH-----------------------------------------------------------------------------------------------------------------------------------------------H-----------HHHHHHH------------------------------------------------------------------------------------------------------------HHHHH----------------------------------- RBBP6_1N raptorxss -EEEEEEE------EEEEE------HHHHHHHHHHHH-------EEEEE-------------EEE---EEEEEE---------------------------------------------HHH----HHHHHHHHHH-----------------------EEE-------EH----------H-------------HHHEEEE-------EEEE----EEEE---HHHHHHHHHH-------------HH--------E------H----EE---------HHHHHHHHH-----E----------HHH----HHHHHHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHH-------------------------------------------------------------------------------------------------------------------------------------------------------H------------------------------HHH-HHHHHHHHHHHHHH--------------------------------------------------------HHHHH-----------HHHHH---------------HHHHHH----HH-----------------------------EEE------------- RBBP6_1N SPARROW --EEEEEE-------EEEE----E-HHHHHHHHHHH---------EEEE-------E-----E-----EEEEE-------------E--------------------------------------HHHHHHHHHHH-----------------------------------------------------------HHH-----------EEE-----EEEE---HHHHHHHHHH---HHH------------------------------E---------HHHHHHHHH-----------------------HHHHHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ RBBP6_1N *SPARROW --EEEEEEEE-----EEEEE--EEEEHHHHHHHHHHHH-----EEEEEE------EE-----E-----EEEEEE------------EEEE--------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--HH----------------H--H---EEEE-------------HHHHH-----HHHHHH--------EEE-----EEEE---HHHHHHHHHHHHHHHHHH-HH-HH------HHHH-HHHHHHHH---EE---HHHHHHHHHHHHHHHH-----HHHH-----H-H-E-HHHHHHHHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------HHHHHHHH----------------------HHHHHHHHHHHHHHHHHHHHHHH-------------------------------------------------------------------------H-------------------HH-----------HHHHHHHHH-------HH-----EEE-------------- RBBP6_1N HMMSTR -EEEEEEE-----EEEEEE---EEEHHHHHHHHHHHH------EEEEEEE-----EE-----EEE----EEEEEEE----------EEE-------------------------------------HHHHHHHHH-----------------------------------HHH--HHH---------------------------------------EEE----HHHHHHH-----------------------HHH------------EE------EE---HHHHHHHH----------------------HHHHHHHHHHHHH----HHH----------------HH---------------------------------------------------------------EEEEEE------------------------H--------HHHHHHHH-----E-------HH-------------------------------------------HHH--------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------------------EE-----------------------------------------------------------------------------------------HHHHHHH----------HH----------HHHHHHHHHHHHHHHHHHHHHHHHHH--------------------------------------------------------------------------------------------------------HHHHH-------------------EE-------------- RBBP6_1N porter -EEEEEEEE-----EEEEE----EEHHHHHHHHHHH---------EEEE----HHH------------EEEEEEE----------EEEE---------------------HHHHHHHH-HHH----HHHHHHHHHH-----------------------EEE-------EE----------------E-------HHHEEE---------EE-----EEEEE--HHHHHHH-------------------------EE----HHHH----E------HHHHHHHHHHHH-----E-----------------HHHHHHHHHHHH-----HHHH-----------------------------------EE--------------------------------------------------------------------HHHH----------EEEEEE-------------------------------------------------------E----------------------------------------------------------------------------------EE----------------------E----------------HHHHHHHHHHH--HHH------------HHHHHHH----------------------------------------------------------------------------------------------------HHHHH--------------------------------------------HHHH--HHHHHHHHHHHHHHHH--E---------------------------------------------EE-------HHHH----------------------------------------------HHHHHHHHH-------------EEEEE------------- RBBP6_1N spine --EEEEEE--------------EEEE-------------------EEE---------------------EEEEEE----------EEEEE--------------------HHHHHHHHHHHHH----HHHHHHHHH------------------------EE----------------------------------EEEEE---------EEE--------------------------------------------EEEE--------EEEE-----------HHHHH------------------HHHHHHHHHHHHH------------------------------------------------EEEE------------------------------------------EEEEEE------------------HHHHH--------EEEE----------EEE-----------------------EE-------------------EEE--------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHH------------------------EEE---------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------EEEE------------- RBBP6_1N nnssp ---------------EEEE--EEEEHHHHHHHHHHHHHHHH----EEEE-------------------EEEEEE------------EEEEE--HHHHHHHHHH-------HHHHHHHHHHHHH---HHHHHHHHHHH----------------------------------------------------------HHHHHHH------EEEEE-----------HHHHH-------------------------HHHHHHHHHHH----EEEE-------HHHHHHHHHH---------------HHHHHHHHHHHHHHHH--------HHHHHH---------------------------------EEEEE--------------------------------------EEEEEEEEEEE---------------HHHHHHHHH-----HHHHHHHHHHH---------HHHHHHHHHH---------EEEEEE-------------------------------EEEEEE--------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------------------EEEEE---------------------------------------------------------------------------------------HHHHHHH----------------------HHHHHHHHHHHHHHHHHHHH---------------------HHH--------------------------------------------------------------------------------------HHHHHHHHH-------------EEEEEE------------ RBBP6_1N pssfinder ---EEEEE-EEE----------EEEE----EEE-------EEE--EEEEE--EEHHHH---------EEEEEEEEEE--EE---EEEEEE-----EEEEE----------HHHHHHHH-HHHH---HHHHHHHHHH--------EE-------------EEEE---------------------------------EEEEEE--------------EEEEEE--HHH-----------------------------EEEEE-----EEEEEEE-----HHHHHHHEEEEE-------------------HHHHHHHHHHHH-EE-----HHH------------------HHHHH--------------EEEE------------EE--------------------------EEEEEEE------------------HHHH---------------EE-------------EE--EE----EE------EEE-------------------EEE----EE----EEEE-------------------------EE----------------------------------------------------------EE---------------------HHHHHHHHHHHHHHHH----------HHHHHHHHHHH--HHH----------------------------------------------------------------------------------------------------------------HHHHHHHH----------------EE------HHHHHHHHHHHHHHHHHH----------------------------------------------HHHHHH---------------------------------------------------------HHHHHH----------------EEEEEE------------ RBBP6_1N sspal --EEEEEEE----EEEEEEE-EEEEHHHHHHHHH-----------EEEE--------------------EEEEEEE---EEEEEEEEEEE----------------HHHHHHHHHH---HHHHHHHHHHHHHHHH-----------------------EEEEE--------------------------------EEEEEEEE------------------HHHHHHHHH------------------------HHHHHHHHH-----EEEE---------HHHHHHHHH----------------HHHHH-HHHHHHHHHHH----HHHHHHHHH------------HHHHHHHHHHH---------EEEEEEE------------------------------------EEEEEEEEEE-------------HHHHHHHHH------EEEHHHHHHHHH--EEEEEEE--------------------EEEE---------------EEEEEEE--------------------------------------EEEEE-------------------------------------EEEE--------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHH------------------EEEE----------EEEEEEE-----------------------------------------------------------------------HHHHHHHHHH-----------------HHHHHHHHHHH--HHHHHHHHHH-------------------------------------------------------------------------------------------HHHHHHHHH---------HHHHH------------------EEEE------------- RBBP6_1N ssp ----------------------------HHHH----------------------------------------------------------------------------------------------HHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------HHHH-----------------------------HHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_1N sspred --EEEEEE-------EEEE------HHHHHHHHHHH--------EEEEE-------------------EEEEEEE----------EEE--------------------------------------HHHHHHHHHHH-------------------------------------------------------------H----------EEEE----EEEE---HHHHHHHHHHH--------------------------HHHHHH-------------HHHHHHHHH-----------------------HHHHHHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_1N netsurfp --EEEEEE--------EE-------HHHHHHHHHHHH-------EEEEE-------------E-----EEEEEEE----------EEEE------------------------------HHH-----HHHHHHHHHHHHH-------------------EE---------------------------E---------EE---------EEE-----EEEEE--HHHHHHHHHHHHHH-HHH----HH---------------------EEE--------HHHHHHHHHH----E-----------------HHHHHHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HH--------------------------------------------------------------------E-------------------HH-------------------EEE-------------- RBBP6_1N soprano --EEEEEE-------EEEE----E-HHHHHHHHHHH---------EEEE-------------E-----EEEEEEE-----------EEE------------------------------HHH----HHHHHHHHHH---------------------------------------------------------------E---------EEE-----EEEE---HHHHHHH-H-------------------------------------E---------HHHHHHHHH-----------------------HHHHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHH--HH---------------------HHH--------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------HH--------------------EE-------------- RBBP6_1N consensus MATEIGSPPRFFHMPRFQHQAPRQLFYKRPDFAQQQAMQQLTFDGKRMRKAVNRKTIDYNPSVIKYLENRIWQRDQRDMRAIQPDAGYYNDLVPPIGMLNNPMNAVTTKFVRTSTNKVKCPVFVVRWTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDSPVRAMTWSHNDMWMLTADHGGYVKYWQSNMNNVKMFQAHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERILRGHGADVKCVDWHPTKGLVVSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKLFDIRNLKEELQVFRGHKKEATAVAWHPVHEGLFASGGSDGSLLFWHVGVEKEVGGMEMAHEGMIWSLAWHPLGHILCSGSNDHTSKFWTRNRPGDKMRDRYNLNLLPGMSEDGVEYDDLEPNSLAVIPGMGIPEQLKLAMEQEQMGKDESNEIEMTIPGLDWGMEEVMQKDQKKVPQKKVPYAKPIPAQFQQAWMQNKVPIPAPNEVLNDRKEDIKLEEKKKTQAEIEQEMATLQYTNPQLLEQLKIERLAQKQVEQIQPPPSSGTPLLGPQPFPGQGPMSQIPQGFQQPHPSQQMPMNMAQMGPPGPQGQFRPPGPQGQMGPQGPPLHQGGGGPQGFMGPQGPQGPPQGLPRPQDMHGPQGMQRHPGPHGPLGPQGPPGPQGSSGPQGHMGPQGPPGPQGHIGPQGPPGPQGHLGPQGPPGTQGMQGPPGPRGMQGPPHPHGIQGGPGSQGIQGPVSQGPLMGLNPRGMQGPPGPRENQGPAPQGMIMGHPPQEMRGPHPPGGLLGHGPQEMRGPQEIRGMQGPPPQGSMLGPPQELRGPPGSQSQQGPPQGSLGPPPQGGMQGPPGPQGQQNPARGPHPSQGPIPFQQQKTPLLGDGPRAPFNQEGQSTGPPPLIPGLGQQGAQGRIPPLNPGQGPGPNKGDSRGPPNHHMGPMSERRHEQSGGPEHGPERGPF WDR33_1N sequence ------------------------------HHHHHHHHHHH--------------------HHHHHHHHH---------------------------------------HHEE--------EEEEEE-----EEEE-----EEEEE-------EEE--------EEEEEE----EEEE------EEEE------HHHH--------EEEE------EEE-----EEEEEE----EEEEEE-----------------EEEE--------EEEE--------EEE------EEEEEE-----EEEEE-----HHHHHHHHHHHHHHHH--------EEEEE---------------EEEEE----------------------------EE---------EEEE--------------------------------------------HHHHHHHHHHH--------------------HHHH-------------------HHHHHH------------------HHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- WDR33_1N psipred ------------------------------------------------------EEEE---HHHHHHHHHH----------------------------------EEEEEEEE--------EEEEEE-----EEEEE----EEEEE------HHHHHHHHHHHHEEEEE-----EEEE-----EEEEEE-----EE----HHHHHH----------EEEE----EEEEEE-------EEE-------EEE-------EEEEE-------EEEE-------EEEE-----EEEEEEEE----EEEEE----EEEEEEHHHHHHHHHHH-------EEEEE------EEEE-----EEEEEEE---------HHHHHHHHHH-------EEEEE--------EE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ WDR33_1N prof --------------------------------------------------------EE---HHHHHHHH--------------------------------HHHHHHHHHHHHHHH----EEEEEEE-----EEEEE----EEEEE------HHHHH-------EEEEE----EEEEE----EEEEEE--------EEE-----EEEEEEE--------E-----EEEE-------HHHHH--------EEE----EEEEE-------EEEEEE------EEEEE-----EEEEEEE----HHHHHHHHHHHHHHHHHHHHH--EEE---------EEEEEEE---EEE----EEEEEEE---------HHHHHHHHHHH--------EEE------EEEEEE-----------------------------------EE----------------EEE----------------------------------E----------------------------EE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- WDR33_1N jnet --------------------------------------EEE--------------EEE---HHHHHHHH-------------------------------------HHHHHHH-------EEEEEEE-----EEEEE----EEEEEE----EEEEEEE-----EEEEEEE----EEEEE----EEEEE------EEEE------EEEEEE-----EEEEE----EEEEEE-----EEEEE-----EEEEEEE-----EEEE-------EEEEE-------EEEE------EEEEEE-----EEEEE----EEEEEE--------EEE------EEEEEE------EEEE-----EEEEEEE-----EEE-HHH---HEEEEEE-----EEEE-----EEEEEE------------------------------------EE---------EEE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- WDR33_1N sable ------------------------------------------------------EEEE----HHHHHHHH---------EEE-----EEEEE-------------HHHHHHH---------EEEEEEE---EEEEEEE---EEEEEEE---EEEEEEE----EEEEEEEE---EEEEEEE---EEEEEE---EEEEEEE----EEEEEEEE----EEEEEE---EEEEEEE--E--EEEEE---EEEEEEEEE--EEEEEEEEE----EEEEEE----EEEEEEE----EEEEEEEE---EEEEEEE---EEEEEEE------EEEEE----EEEEEEE------EEEEEE---EEEEEE---EEEEHEEEE-----EEEEEE----EEEEEEE---EEEEEE-----E----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- WDR33_1N proteus ----------EEEEE----------------------EEEE-----EEEEE----EEEEE-----EEEEEE-----EEEEEE-----EEEE-----EEEEE-----EEEEEE---------EEEEEE-----EEEEE----EEEEEE-----EEEEEE-----EEEEEE-----EEEE-----EEEEEE-----EEEEE-----EEEEEE-----EEEEE----EEEEEE-----EEEEE------EEEEEE-----EEEEE------EEEEEE-----EEEEE------EEEEEE-----EEEEE----EEEEEE------EEEEE------EEEEEE-----EEEEEE----EEEEEE-----EEEEEE-----EEEEEEE-----EEEE-----EEEEEE------EE------EEEEEE-----EEEE-----EEEEEE-----EEEEEE----EEE------EEEEE-----------------------------HHHHHHHHH---------HHHH--HHH--HHHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHH----------------------------------------------HH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H--------------------------------------------------------------------------------------------HH--------------------------------------------------------------------HHH---------------- WDR33_1N sspro4 -------------------------------------------------------EEE---HHHHHHHHH---------EEE------EE-----------------EEEHHHH-------EEEEEE-----EEEEE----EEEEEE-----EEEEEE-----EEEEEE-----EEEEE----EEEEE-----HHHHHHH----EEEEEE-----EEEEE----EEEEEE----EEEEEEEE----EEEEEE-----EEEEE-------EEEEE-----EEEEEE-----EEEEEEE----EEEEEE---EEEEEE-------EEEEE-----EEEEEE------EEEEE----EEEEEE------EEHHH------EEEEEE-----EEEEE----EEEEEE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- WDR33_1N psspred -----------------------------HHHHHHHHHHHH--------------EE---HHHHHHHHHHH--------------HHHHHH----------HHHHHHHHHHHH--------EEEEEE----EEEEEE----EEEEE------EEE--H-------EEEEE----EEEEEE---EEEEEE--HHHHHHHHH------EEEEE-----EEEEE---EEEEEE----EEEEEEE-----E-EEE------EEEE-------EEEEE------EHHHHHH----E-EEEEE---EEEEEEE---EEEHHHHHHHHHHHHHHH-----E-EEEEE-----EEEE-----EEEEEE------------HHHHHHHHHHH-----EEEE-----EEEEEE---------------------------------------------HHHHHHHHHHH------------------HHHHHHHHH--------------------------------------------HHHHHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- WDR33_1N spineX -------------------------------------------------------EE---HHHHHHHH--------------------H--------------------EEE----------EEEEE-----EEE------EEEEE------HHHHHHH---HHHHHE------EEEE------EEEEE-----HHHHHH-HHHHHH-----------E-----EEEEE-----EEEEEE------------------EEE--------EEEE-------HHEHH-----EEEEEE-----EEEEE----EEEEE--------EEEE--------EEEE----------------EEEEE-----------------E----------EE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ WDR33_1N raptorxss -------------------------------------------------------EEE--HHHHHHHHH-----------EE-----HHH-----HH-----HHHHHHHHHHH--------EEEEEE----EEEEEE----EEEEE------EEEEE------EEEEEE-----EEEEE----EEEEE-----EEHHEE-----HEEEEE-----EEEEEE---EEEEEE--H-EEEEEE------EEEE-----EEEEEEE-------EE-E------EEEHHHH----EEEEEE-----EEEEEE---EEEHHHHH----HHHEEE-----EEEEEE------HEEE-----EEEEEE------H-EE---HHHHEEHHH------EEEE-----EEEEEEE-------HHH-H-----HHH-----------HHHHHH-------------------------------------------------------------------E---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E---EEEEE--EEEE-----------------------------------------------------------------------------------------------------------E-E----------------------------------------------------------------- WDR33_1N SPARROW --------------------------------HH---------------------------HHHHHHHHH----------------HHHHH------------------EEE---------EEEEEE-----EEEE-----EEEEE----E-HHHHHHH-----EEEEEE----EEEEE----EEEEE------H-HHH-----------------EE------EEEEE------HHEE---------EE-E-----EEEE-----------E------EEEEH------EEEEEE-----EEEEEE---HHHHHHHHHHHHHHEEE------EEEEEE------EEEE------EEEEE--------------HHHHHHHHH-----EEEE------EEEEE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- WDR33_1N *SPARROW ------------------------------HHHHHHHHHH----HHHHHHHHHHHEE-HHHHHHHHHHHHHH--------------HEHHHH------------EEEEEEEE-----EE--EEEEEE-----EEEE----EEEEEEE--EEEHHHHHHHHHHHEEEEEE-----EEEE------EEEE------HHHHHHHHHHHHHHH----H-EEEEE----EEEEEE---HHHHHHH------EEEEE-----EEEEE-------EEEEE------EEEEEEE---EEEEEEE-----EEEE--HHHHEEEE-HHHHHHHHHHHH------EEEEE------EEEE------EEEEEE-----HHHHHHHHHHEEEEEEE----EEEEE-----EEEEEE----------H-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E WDR33_1N HMMSTR -----------------------HH------------EEEEEE---EEEE------EEEE-----HEEE-------EEEEEE------EEE------E--------EEEEEEEE-------EEEEEE-----EEEEEE---EEEEEE-----EEEEEE-----EEEEEE-----EEEEEE----EEEEE----EEEEEE-----EEEEEE-----EEEEEE----EEEEE-----EEEEE------EEEEEE-----EEEEEE-----EEEEEE-----EEEEE------EEEEEE-----EEEEEE---EEEEEE-----EEEEEE------EEEEEE-----EEEEEEE----EEEEE-----EEEEEE------EEEEEE-----EEEEEE---EEEEEE------EEE----EEE--------EEEEEE----EEEEEE-----EEEEEE-------------EEEE------------------------------HHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- WDR33_1N porter ---------------------------------HHHHHHHH-----HHHHH-----------HHHHHHHH--------------------------------------EEEE---------EEEEEE-----EEEE------EEEE------HHHHHH----------------EEEE------EEEE------HHHHHHHHHHHHH---------EEE------EEEEE---------------------------EEE----------------------EE------EEEEEE-----EEEE-----HHHHH----HHHHHHHHH-------EEE-----------------EEEEE-----------------EE---------EEE---------EE-----------------------------------EEE---------HHHHHHH----------EEEE--------HHHHH------------------------------------------------------HHHHHHHHHH------HHHHHHHHHHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ WDR33_1N nnssp ---------EEEEE-----------------HHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHHHHHHHH----------------------EEEEEEEE---------EEEEEE-----EEEE-----EEEEEE-----HHHHHHH----EEEEEE-----EEEE-----EEEEEE-----HHHHHHHHHHHHHH-------EEEEEE------HHHHHHHHHHHHHHHH--EEEEEEE-----EEEE--------EEEE------EEEEEEEE--EEEEEEEE----EEEE--HHHHHHHHHHHHHHHHHHHHH--------------------------EEEEEEEEEEEEE--HHHHHHHHHHHHH------EEEE-------EEEEEE-------------------------------EEEEE-----HHHHHHHHHHHHH------------------HHHHHHHHHHH-------------HHHHHHHHH---------------HHHHHHHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHH----------------------------------------HHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- WDR33_1N pssfinder -----------EE----------HHH------HHHHHHHHHHHHHHHHHHHHH------------HHHHHHHHHHHH-HHHH---------------EE-------EEEEEE--------EEEEEEE----EEEEE-------EEEE-----HHHHHHH----EEEEE-----EEEEE-----EEEEEE-----HHHHHHHHHHHHHH-------EEEE-----EEEEEE----HHHHHH-----EEEEEE-----EEEEE--------EEE--------EEEE------EEEEEEE------EEE---EEEEEEE---HHHHHHHHH-----------------EEE------EEEEEE------EEEEEEE----HHH--HHHHHHEE---------EE--------------------------------------EE--------HHHHHHHH---------EEEE---------HHH-------------------HHHHHH-----------EEE-------EEEEHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- WDR33_1N sspal ------------HHHHHHHHH-----------HHHHHHHHHEEE-HHHHHHHHH--------HHHHHHHHHHHH-------------------------------EEEEEEE-----EEEEEEEEEEE--------------EEEEEEEEEHHHHHHHHH---EEEEEEE-------------EEEEHHHHHHHHHHHHHHHHHH-------------------EEEHHHHHHHHHHHHHH-----EEEE----EEEEEEE-----------------HHHHHHHHH---EEEEEEEEE--HHHHHHHHHHHHHH-HHHHHHHHH----HHHHHHHHHH----------------EEEEEEE-----------------------EEEEEEE----------------HHHHHHHHH--------------------EEEE------HHHHHHHHH---------EEEEEEE--HHHHHHHHHH---------------HHHHHHHHHHH---------HHHHHHHHH--HHHHHHHHHHHHHHHHHEEEHHHHHHHHHH-HHHHHHHHHHHH----------------------------------HHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHH------------- WDR33_1N ssp ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ WDR33_1N sspred -------------------------------H-----------------------EEE---HHHHHHHHH-----------E--------------------HHHHHHHHHHHH-------EEEEEE-----EEEEE----EEEEE-------EEEEEE----EEEEEE-----EEEEE----EEEEE------H-EHH--------EEE------EEE-----EEEEEE------EEEE-----EEEEE------EEEEE--------EEEE-------HHHHHH----EEEEEE-----EEEEE----EEEEEEHHHHHHHHHHHH-----EEEEEE------EEEEE----EEEEEE--------E--------EEEHHH----EEEEE------EEEEE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- WDR33_1N soprano -------------------------------------------------------EE----HHHHHHHHH------------------------------------EEEEEE---------EEEEEE-----EEEEE----EEEEE------H--HHH-----EEEEEE-----EEEE-----EEEEE------HHHHH-----HEEEEE------EEEE----EEEEEE-----EEEEE------EEEEE------EEEE--------EEEE-------EEEE------EEEEEE-----EEEEE----EEEEEEHH-HHHHHHEE-------EEEEE------EEEE-----EEEEEE-----------------EE---------EEEE------EEEEE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- WDR33_1N consensus MNPSTPSYPTASLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQHTKDAEHALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFVKNLDKSINNKALYDTVSAFGNILSCNVVCDENGSKGYGFVHFETHEAAERAIKKMNGMLLNGRKVFVGQFKSRKEREAELGARAKEFPNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRTFEQMKQDRITRYQVVNLYVKNLDDGIDDERLRKAFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAYLTNEYMQRMASVRAVPNQRAPPSGYFMTAVPQTQNHAAYYPPSQIARLRPSPRWTAQGARPHPFQNKPSAIRPGAPRVPFSTMRPASSQVPRVMSTQRVANTSTQTVGPRPAAAAAAAATPAVRTVPRYKYAAGVRNPQQHRNAQPQVTMQQLAVHVQGQETLTASRLASAPPQKQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLYMLESPESLRSKVDEAVAVLQAHQAKEATQKAVNSATGVPTV PABP-3_1 sequence -----------EEEE--------HHHHHHHH-----EEEEEEE----------EEEEEE--HHHHHHHHHH----EE--EEEEEEE--------------EEE--------HHHHHHHHH----EEEEEEEE------EEEEEEE--HHHHHHHHHHH---EE--EEEEEEE-----HHHHHHH-------------------HHHHHHHH------EEEEEEE--------EEEE----HHHHHHHHHHH---EE--EEEEEE----HHHHHHHHHHHHHH-----------EEEEEE-------HHHHHHHH-----EEEEEEEE-----EEEEEEE---HHHHHHHHHHH---EE--EEEEEEEEE--HHHHHHHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH---HHHHHHHHHHHHHHHHHH------------------HHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHH---------- PABP-3_1 psipred -----------EEEE------HHHHHHHHHHH----EEEEEE-----------EEEEE---HHHHHHHHHHH---------EEEEEE-------------EEEE--------HHHHHHHHHH--EEEEEEEE-------EEEEE--HHHHHHHHHHHHH-------EEEEE-----HHHHHHHHHHHHH---EEEE-------HHHHHHHHHH---EEEEEEEE--------EEEEE---HHHHHHHHHHH--------EEEEE----HHHHHHHHHHHHHHHHHHHHHH----EEEEE-------HHHHHHHH-----EEEEEEEE-------EEEEEE--HHHHHHHHHHHHHHH-----EEEEEHHHHHHHHHHHHHHHHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHH---HHHHHHHHHHHHHHHHHHH-HHH--HHHHHHHH--HHHHHHH---HHHHHHHHHHHHHHHHHHHH----------------- PABP-3_1 prof -----------EEEE--------HHHHHHHH-----EEEEEEE------------------HHHHHHHHHHH---------EEEEE------------EEEEEE---------HHHHHHHH----EEEEEEE------EEEEEEE-HHHHHHHHHHHH---EE---EEEE--------------------EEEEEE-----HHHHHHHHHH-----EEEEEEEE----------EEE---HHHHHHHHHHH--------EEEEE----HHHHHHHHHHHHHHHHHHHHHH-----EEE--------HHHHHHHH------EEEEEEE-----E--EEEEE---HHHHHHHHHHH--------EEEE----HHHHHHHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHH------------------EEEE-----HHHHHHHHHHHHHHHHH------------------- PABP-3_1 jnet -----------EEEE--------HHHHHHHHHH---EEEEEEE----------EEEEEE--HHHHHHHHHHH---------EEEEE-------------EEEEE---HH--HHHHHHHHHH---EEEEEEEE-------EEEEEE--HHHHHHHHHHH---E----EEEEEEE------------------EEEEE-------HHHHHHHHHH---EEEEEEEE--------EEEEEE--HHHHHHHHHHH--------EEEEEE-----------HH---------------EEEEEE-------HHHHHHHHHH---EEEEEEEE-------EEEEEE--HHHHHHHHHHH---E----EEEEEEE------HHHHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------HHHH-----HHHHHHHHHHHHHHHHHH-----------E-----HHHHHHH--HHHHHHHHHHHHHHHHHHH------------------ PABP-3_1 sable -----------EEEEE-------HHHHHHHHHHH-EEEEEE--EEE-------EEEEEE---HHHHHHHHHH--EE---EEEEEE-------------EEEEEE-------HHHHHHHHHHHEEEEEEEEE-E------EEEEEE--HHHHHHHHHHH--------EEEEEE-EE------E---------EEEEE-------HHHHHHHHHH--EEEEEEEEE----EEE-EEEEEE--HHHHHHHHHHH-------EEEEEEEE-------HHHHHH---------------EEEEE-------HHHHHHHHHHH--EEEEEEE--------EEEEEEE-HHHHHHHHH---------EEEEEEE---HHHHHHHHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------HHH---------HHHHHHHHHHHHHHHHHHH----HHHHHHHHH------HHHH---HHHHHHHHHHHHHHHHHHHH----------------- PABP-3_1 proteus ------------EEE--------HHHHHHHH-----EEEEEEEE----------EEE----HHHHHHHHHHH--HHH----EEEEE----HHHH-----EEEEE-------HHHHHHHHH----EEEEEEEEE-------EEEE---HHHHHHHHHHH--------EEEE-----HHHHHHHHH--HH----EEEE-------HHHHHHHHHH---EEEEEEEE---------EEEE---HHHHHHHHHHH--------EEEEEE----HHHHHHHHHHHHHHHHHHHHH-----EEEE-------HHHHHHHH-------EEEEEE---------EEE---HHHHHHHHHHH---------EEEHH---HHHHHHHHHHHHHHHHHHH------------------------------------------------------------------------------------------------------HH--------------------------------------E--------HHHHHH---HHHHHHHHHHHHHHHHHHH-HHHHHHHHHHH----HHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHH---------- PABP-3_1 sspro4 ----------EEEEE--------HHHHHHHHHHH--EEEEEEEE---------EEEEE---HHHHHHHHHHH--EEE--EEEEEEE-------------EEEE--------HHHHHHHHHHH--EEEEEEEE------EEEEEEE--HHHHHHHHHHH--EEE--EEEEEEE----HHHHHHHHH------EEEE--------HHHHHHHHHHH--EEEEEEEE-------EEEEEE---HHHHHHHHHHH--EEE--EEEEEE----HHHHHHHHHHHHHHH-----------EEEE--------HHHHHHHHHH---EEEEEEE-------EEEEEEE--HHHHHHHHHHH--EEE--EEEEEEE---HHHHHHHHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHH--HHHHHHHHHHHHHHHHHHH-------HHHHHHH--HHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHH----------- PABP-3_1 psspred ----------EEEEE--------HHHHHHHHHHH----EEEEEE---------EEEEE---HHHHHHHHHHH-------EEEEEEE-------------EEEE--------HHHHHHHHHHH--E-EEEEEEE------EEEEEE--HHHHHHHHHHHH--EE--EEEEEE------HHHHHHHHHHH---EEEE--------HHHHHHHHHHH--E-EEEEEE--------EEEEE---HHHHHHHHHHH---EE--EEEEEE----HHHHHHHHHHHHHHHHH--------EEEEE--------HHHHHHHHHHH--E-EEEEEE-------EEEEE---HHHHHHHHHHH--EEE---EEEEEEE--HHHHHHHHHHHHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHH--HHHHHHHHHHHHHHHHHHH--HHHH----HHHH--HHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHH---------- PABP-3_1 spineX ----------EEEEE--------HHHHHHHH-----EEEEEEE----------EEEEEE--HHHHHHHHHH---------EEEEEE-------------EEEE--------HHHHHHHHHH---EEEEEEEE-------EEEEEE--HHHHHHHHHHH---EE---EEEEEEE------------------EEEE--------HHHHHHHH-----EEEEEEE---------EEEEEE--HHHHHHHHHH---EEE---EEEEEE----------------------------EEEEE--------HHHHHHHE-----EEEEEEEE-------EEEEEE--HHHHHHHHHH---EEE---EEEEEEEE-------E---HHHHHH------------------------------------------------------------------------------------------------------HHHHHH----------------------------------------------HHHHHH-------------EE---HH-----------HHHH---HHHHHHHHH-HHHHHHHHHHHHHHHHHHH------------------ PABP-3_1 raptorxss ----------EEEEEE-------HHHHHHHHH----EEEEEEEE---------EEEEEE--HHHHHHHHHH----EE---EEEEEH------------EEEEEE---H---HHHHHHHHHHH--EEEEEEEE-------EEEEEE--HHHHHHHHHHH--EEE--EEEEEEE-------------------EEEEE-------HHHHHHHHHH---EEEEEEEE-------EEEEEEE--HHHHHHHHHHH--EEE--EEEEEE--------HHHHHHH---------------EEEEE-------HHHHHHHHH----EEEEEEEE-------EEEEEE--HHHHHHHHHHH---EE--EEEEEEEE-E-HHHHHHHH-HHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------HHHH------HHHHHHHHHHHHHHHHH---------HHHH---HHHHHHHH--HHHHHHHHHHHHHHHHHHHH-HHHHHH---------- PABP-3_1 SPARROW ------------EEEE-------HHHHHHHHH----EEEEEEEE---------EEEEEE--HHHHHHHHHHH---EE---EEEEEE--------------EEEE-------HHHHHHHHH----EEEEEEEE-------EEEEEE--HHHHHHHHHHH---EE---EEEEEE-------------------EEEEE-------HHHHHHHHHHH--EEEEEEEE------E-EEEEE---HHHHHHHHHHH---EE--EEEEEEE------HHHHHH----------------EEEEEE-------HHHHHHHHHH---EEEEEEEE-------EEEEEE--HHHHHHHHHHH---EE---EEEEEEEE------H-----HHHH------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH---HHHH-----HH--HHHHHH---H----HHH-----HHHHHHHH--HHHHHHHHHHHHHHHHHHHH-----HHH--------- PABP-3_1 *SPARROW --H-H----EEEEEEEE------HHHHHHHHHHH--EEEEEEEE------EE--EEEEEE-HHHHHHHHHHH--EEE----EEEEEEE--H-HHH---EEEEEE-HHHHH-HHHHHHHHHHHEEEEEEEEEE------EEEEEEEEEHHHHHHHHHHE----E---EEEE-----HHHHHHHHHHHHHHHHHEEEE-------HHHHHHHHHHH-EEEEEEEEE-----EE---EEEEE-HHHHHHHHHHH---EE---EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH---EEEEE---H---HHHHHHHHHHHEEEEEEEEEEH-------EEEEEE-HHHHHHHHHHH---EEEE---HHHHHHHHHHHHHHHHHHHHHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHH-HHHHHHHHHHHHHHHHHHH-HHHH-EEE--EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------------E PABP-3_1 HMMSTR -----------EEEEE-------HHHHHHHHHHH--EEEEEEEE------EEEEEEEEE--HHHHHHHHHHH---EE--EE-EEEE-----HHHH----EEEEE-------HHHHHHHHH----EEEEEE----------EEEEE--HHHHHHHHHH----EE--EEEEEEE-------------------EEEEE-------HHHHHHHHH----EEEEEEEE-----EEEEEEEEE--HHHHHHHHHHH---EE--EEEEEEE-----------------------------EEEEE-------HHHHHHHH-----EEEEEEEE-----EEEEEEEE--HHHHHHHHHHH---E----EEEEEE---------------HH-------------------------------------------------------------------------------------------------------------------------------------------------------------HHHH--------HHHHHHHHHHHHHHH-HHHHHHHHHHH----HHHHHHHHH-HHHHHHHHHHHHHHHHH-------------------- PABP-3_1 porter ----------EEEEEE-------HHHHHHHHH----EEEEEEEE---------EEEEEE--HHHHHHHHHHH---EE---EEEEEE-------------EEEEE-------HHHHHHHHHH---EEEEEEEE------EEEEEEE--HHHHHHHHHHH--EEE---EEEEEE-----HHHHHHH-------EEEEE-------HHHHHHHHH----EEEEEEEE------EEEEEEEE--HHHHHHHHHHH--EEE---EEEEEE-----HHHHHHHHHHHHHH----------EEEEE-------HHHHHHHH----EEEEEEEEEE-----EEEEEE---HHHHHHHHHHH--EEE----EEEEE----HHHHHHHHHHHHHHHH---------------------HHH-------------------------------------------------------------------------------------------------------------------H-H-HHHH---HHHHHHHH----HHHHHHHHHHHHHHHHHHH-HHHHHH-HHHHH---HHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHH--------- PABP-3_1 spine ------------EE--------HHHHHHHH-------EEEHHHHHHH-------EEE-------HHHHHHH----------EEEEE--------------EEE---------HHHHHHHHH------EEEE----------EEEE--HHHHHHHHHHHHHHH----EEEEE----HHHHHHHHHHHHH----HHHHH------HHHHHHHHH------EEEEE----------EEEE---HHHHHHHHHHH--------EEEEEHHHHHHHHHHHHHHHHHHHHH----EEEEEHHHHH-------HHHHHHHH--------HHHHHH-------EEEEE--HHHHHHHHHHH---EEE-----HHHHHH-HHHHHHHHHHHHHHHHHHH-----------EEEE-----------------------------------------------------------------------------------HHHHHHHH------------------------------HHHHHEEE-----HHHHHH------HHHHHHHHHHHHHHHHH----------EEEEE---HHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHH------E PABP-3_1 nnssp -----------EEEEE-------HHHHHHHHHHH--EEEEEEEE---------EEEEEE--HHHHHHHH-------------EEEE-----HHHH----EEEEE-------HHHHHHHHHHH--EEEEEE----------EEEEE--HHHHHHH-----EEEE--EEEEEEE---HHHHHHHHHHHHHH---EEEEE------HHHHHHHHHHH--EEEEEEEE---------EEEEE--HHHHHHHHHHH--------EEEE-HHHHHHHHHHHHHHHHHH-----EEEEEEEEEEEE-------HHHHHHHH--------HHHHHH------EEEEEE--HHHHHHHHHHH--EEEEE--HHHHHHHHHHHHHHHHHHHHHHHHHHHH-----------EEEEE------------HHHHHHH---------------------------------------------------------------HHHHHHH----------------------------------------------HHHHH---HHH---------HHHHHHH----HHHHHHHHHH--HHHHHHHHH-HHHHHHHHHHHHHHHHHH-HHHH-------------- PABP-3_1 pssfinder -----------EEEE------HHHHHHHHH---------HHHHHHHH-------EEEE------HHHHHHHH----------EEEE--------------EEE--------HHHHHHHHHHH--EE--EEEE--------EEEE---HHHHHHHHHHHH-------EEEE------HHHHHHHHHHHH---------------HHHHHHHHHH------EEEE----------EEEE---HHHHHHHHHHH-------EEEEE-HHHHHHHHHHHHHHHHHHHHH------EEEEE----------HHHHHHHH--------HHHHHH------EEEEE---HHHHHHHHHHH--EEEE----HHHHHHHHHHHHHHHHHHHHHHHHHHH-----------EEEEE--------------HHHH---------------------------------------------EE--HHHH-----------HHHHHHHHHHHHHH----EE-----------------HHHHHHHHH-----HHHHHH-----HHHHHHHHHHHHHHHHHHHHHH------EEEEE---HHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHH-------- PABP-3_1 sspal ------------EEEE------HHHHHHHHH-----EEEEEEEHHHHHH---------HHHHHHHHHHHH-----------EEEE------------EEEEEEE--------HHHHHHHHHH--EEEEEEEE-------EEEEEHHHHHHHHHHHHHHH-------EEEEHHHHHHHHHHHHH---------EEEE-HHHHHHHHHHHHHH------EEEEEEE--------EEEHHHHHHHHHHHHHHHH--------EEEE-HHHHHHHHHHHHHHHHHH-----EEEEEEE-EEEE-----HHHHHHHHH---------------------EEEEEEE--HHHHHHHHHH------HHHHHHHHHHHHHHHHH---HHHHHHHHH------------EEEEEEE-------------HHHHHH----------------------------------------------------EEEEEEE---HHHHHHHHH---------------------------EEEEEEEEEE----------------HHHHHHHHHHHHHHHHHH---HHHHHHHHHHH---HHHHHHHHH-HHHHHHHHHHHHHHHH-HHHHHHHHH---------- PABP-3_1 ssp -----------EEEEE-------HHHHHHHHHH---EEEEEEE----------EEEEEE--HHHHHHHHHHH---------EEEE--------------EEEEE-------HHHHHHHHHH---EEEEEEEE-------EEEEEE--HHHHHHHHHHHH-------EEEEEE-------------------EEEEE-------HHHHHHHHHH---EEEEEEEE-------EEEEEEE--HHHHHHHHHHH---------EEEEE-----------------------------EEEEE-------HHHHHHHHHH-----EEEEE-------EEEEEEE--HHHHHHHHHHH---------EEEEE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHH----HHHHH---------EE------HHHHHHH--HHHHHHHHHHHHHHHHHHHH----------------- PABP-3_1 sspred -----------EEEE--------HHHHHHHHHH---EEEEEEEE---------EEEEE---HHHHHHHHHHH--------EEEEEE-------------EEEE--------HHHHHHHHHH---EEEEEEEE-------EEEEEE--HHHHHHHHHHH---EE---EEEEEE-------------------EEEEE-------HHHHHHHHHH---EEEEEEEE-------EEEEEEE--HHHHHHHHHHH---EE---EEEEE-------HHHHHH-----------------EEEE--------HHHHHHHHHH---EEEEEEEE------EEEEEE---HHHHHHHHHHH---EE---EEEEEE------------HHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHH---HHHHHH-----------------------------HHHHHHH---HHHHHHHHHHHHHHHHHHHH-H--------------- PABP-3_1 netsurfp -----------EEEE--------HHHHHHHHH----EEEEEE------------EEEE---HHHHHHHHHHH---EE---EEEEE--------------EEEE--------HHHHHHHHHH----EE-EEEE--------EEEEE--HHHHHHHHHHH---EE---EEEE---------------------EEEE--------HHHHHHHHH----EEEEEEEE--------EEEEEE--HHHHHHHHHHH---EE---EEEE---------HHHH------------------EEEE--------HHHHHHHHH----EEEEEEEE-------EEEEE----H-HHHHHHHH---EE---EEEEEE--------H----HHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH----------HHHHHHHHHHHH----------EE-----HHHHHHH--HHHHHHHHHHHHHHHHHHHH-----H----------- PABP-3_1 soprano -----------EEEE--------HHHHHHHHH----EEEEEEEE---------EEEEEE--HHHHHHHHHHH--------EEEEEE-------------EEEEE-------HHHHHHHHHH---EEEEEEEE-------EEEEEE--HHHHHHHHHHH---EE---EEEEEE-----HHHHHH--------EEEEE-------HHHHHHHHHH---EEEEEEEE--------EEEEEE--HHHHHHHHHHH---EE---EEEEEE----HHHHHHHHHHHHH------------EEEEE-------HHHHHHHH-----EEEEEEEE-------EEEEEE--HHHHHHHHHHH---EE---EEEEEE----HHHHHHHHHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH---HHHHHHHHHHHHHHHHHHH---------HHH----HHHHHHHH--HHHHHHHHHHHHHHHHHHHH-H---H----------- PABP-3_1 consensus MAAAAAAAAAAGAAGGRGSGPGRRRHLVPGAGGEAGEGAPGGAGDYGNGLESEELEPEELLLEPEPEPEPEEEPPRPRAPPGAPGPGPGSGAPGSQEEEEEPGLVEGDPGDGAIEDPELEAIKARVREMEEEAEKLKELQNEVEKQMNMSPPPGNAGPVIMSIEEKMEADARSIYVGNVDYGATAEELEAHFHGCGSVNRVTILCDKFSGHPKGFAYIEFSDKESVRTSLALDESLFRGRQIKVIPKRTNRPGISTTDRGFPRARYRARTTNYNSSRSRFYSGFNSRPRGRVYRSG PABP-2_2 sequence -HHHHHHHHHH---------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----------------HHHHH-----EEEEE-------HHHHHHHH-----EEEEEEE----------EEEEEE--HHHHHHHHH---------EEEEE--------------------------------------------------- PABP-2_2 psipred -HHHHHHHHHHHHH-----------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----------------HHHHH-----EEEEEEE-----HHHHHHHHH----EEEEEEEEE--------EEEEEE--HHHHHHHHH---------EEEEE--------------------------------------------------- PABP-2_2 prof ---------------E------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHH--------------------------------------EEEEEE-----HHHHHHHHH-----EEEEEEEE---------EEEEEE--HHHHHHHHHH--HHHH---EEEE--------------------------------------------------- PABP-2_2 jnet --HHHHHHHH-----------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------------------------EEEEE-------HHHHHHHHHH---EEEEEEEE---------EEEEEE--HHHHHHHHH---------EEEEE--------------------------------------------------- PABP-2_2 sable --------------------------------------------------HHHHHHH----------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------------------------EEEEEE-------HHHHHHHHHH---EEEEEEEE--------EEEEEEE--HHHHHHHHHHH------EEEEEE--------------------------------------------------- PABP-2_2 proteus -HHHHHHHHHH-------------EEE---------------HEE----EEE----HHH-------------------------------------EEE-----EE----------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------------HHHHHH----EEEEE-------HHHHHHHHH----EEEEEEEE---------EEEEEE--HHHHHHHHHH--------EEEEE---------------------------------------------EEE--- PABP-2_2 sspro4 ------------------------------------------HHHHH----------HHHHHH---------------------------------HHHH-HHHH----------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----------------HHH------EEEEE-------HHHHHHHHHH---EEEEEEEE--------EEEEEEE--HHHHHHHHHH---EE--EEEEEEE-------------------------------------------------- PABP-2_2 psspred HHHHHHHHHHHH--------------------------------------------HHHHHH---------------------------------HHHHH-HHHHH----------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------------HHHHHH----EEEE--------HHHHHHHHHH---E-EEEEEE---------EEEEEE--HHHHHHHHHH---E----EEEE-------------------HH------------------------------- PABP-2_2 spineX --HHHHHHHH------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHH-----------------------------------------EEEE--------HHHHHHHH-----EEEEEEEE----------EEEEE--HHHHHHHHHH--------EEEEE---------------------------------------------EEE--- PABP-2_2 raptorxss ----HHHHHH---------------HH------------------H-------------H----------H------------------------HHHHH-HHHH-----------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----------------HHHHH-----EEEEE-------HHHHHHHHHH---EEEEEEEEE--------EEEEEE--HHHHHHHHHH---HH---EEEEEE-------------------------------------------------- PABP-2_2 SPARROW ------HHHH----------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------------------------EEEEE-------HHHHHHHHH----EEEEEEEE------EE-EEEEEE--HHHHHHHHHH---EE--EEEEEEE-------------------------------------------------- PABP-2_2 *SPARROW EEEEEHHHHHH-----------HH---------------------------HH-----HHHHHHH------HH-----------------------HHHHHHHHHH---------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------------HHHHHH--EEEEEEE-EE----HHHHHHHHHH---EEEEEEEE----------EEEEEEEHHHHHHHHHH-HHHE---EEEEEE-------------------------------------------------- PABP-2_2 HMMSTR -HHHHHHHHHHHH-------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----------------HHHHHH-HHHEEEEE-------HHHHHHHHHHH--EEEEEEEE--------EEEEEEE---HHHHHHHHH---EE--EE-EEEE-------------------------------------------------- PABP-2_2 porter --HHHHHHHHHHH---------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------------HHHHH-----EEEEE-------HHHHHHHHHH---EEEEEEEE--------EEEEEEE--HHHHHHHHHH----EE-EEEEEEE-------------------------------------------------- PABP-2_2 spine HHHHHHHHHHH-----------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHH------------EEHHHHHHHH---EEEEE-------HHHHHHHH--------EEEE-----------EEEE---------HHHHHHHH-----EEE-----------------------------------EE----------EEE-- PABP-2_2 nnssp --HHHHHHHHH------------EEEEEE---------------------------HHHHHH------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------------HHHHHHHHH-EEEE--------HHHHHHHH-------EEEEEEE--------EEEEEE--HHHHHHHHHHHHHHH---EEEEEE-------------------------------------------------- PABP-2_2 pssfinder HHHHHHHHHHHH--------------EE-----------------------------HHH--------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------------EEEEEHHHH------EEE--------HHHHHHHH-------EEEEE-----------EEEEE-------HHHHHHHH------EEEEE-----------------EEEEEEE--------EEE----------EEE-- PABP-2_2 sspal HHHHHHHHHHH---------------------------------------HHHHHHHHHHHHH--------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----------HHHHHHHHHH--EEEEE------HHHHHHHHH--------EEEEEEE--------EEEEEEE----EEEEEEE-------EEEEEEE-------------------------------------------------- PABP-2_2 ssp -----HHHHHH-----------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHH--------------------------------EEEEE-------HHHHHHHHHH---EEEEEEE----------EEEEEE--HHHHHHHHHH---EE--EEEEEE--------------------------------------------------- PABP-2_2 sspred ----HHHHHHH-----------------------------------------------HHH--------HHHHHHH--------------------HHH--HH-------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------------------------EEEEE-------HHHHHHHHHH---EEEEEEEE---------EEEEEE--HHHHHHHHHH--------EEEEE--------------------------------------------------- PABP-2_2 netsurfp --HHHHHHHHH----------------------------------------------HHHH-----------------------------------HH------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------------------------EEEEE-------HHHHHHHHHH----EEEEEEE----------EEEEE--HHHHHHHHH---------EEEE------------------------------------------------E--- PABP-2_2 soprano --HHHHHHHHH---------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----------------HHHHH-----EEEEE-------HHHHHHHHHH---EEEEEEEE---------EEEEEE--HHHHHHHHHH--------EEEEE--------------------------------------------------- PABP-2_2 consensus LPPTLAKSQVSSVRKNLKLHLLSVLKHPASLEFQAQITTLLVDLGTPQAEIARNMPSSKDTRKRPRDDSDSTLKKMKLEPNLGEDDEDKDLEPGPSGTSKASAQISGQSDTDITAEFLQPLLTPDNVANLVLISMVYLPEAMPASFQAIYTPVESAGTEAQIKHLARLMATQMTAAGLGPGVEQTKQCKEEPKEEKVVKTESVLIKRRLSAQGQAISVVGSLSSMSPLEEEAPQAKRRPEPIIPVTQPRLAGAGGRKKIFRLSDVLKPLTDAQVEAMKLGAVKRILRAEKAVACSGAAQVRIKILASLVTQFNSGLKAEVLSFILEDVRARLDLAFAWLYQEYNAYLAAGASGSLDKYEDCLIRLLSGLQEKPDQKDGIFTKVVLEAPLITESALEVVRKYCEDESRTYLGMSTLRDLIFKRPSRQFQYLHVLLDLSSHEKDKVRSQALLFIKRMYEKEQLREYVEKFALNYLQLLVHPNPPSVLFGADKDTEVAAPWTEETVKQCLYLYLALLPQNHKLIHELAAVYTEAIADIKRTVLRVIEQPIRGMGMNSPELLLLVENCPKGAETLVTRCLHSLTDKVPPSPELVKRVRDLYHKRLPDVRFLIPVLNGLEKKEVIQALPKLIKLNPIVVKEVFNRLLGTQHGEGNSALSPLNPGELLIALHNIDSVKCDMKSIIKATNLCFAERNVYTSEVLAVVMQQLMEQSPLPMLLMRTVIQSLTMYPRLGGFVMNILSRLIMKQVWKYPKVWEGFIKCCQRTKPQSFQVILQLPPQQLGAVFDKCPELREPLLAHVRSFTPHQQAHIPNSIMTILEASGKQEPEAKEAPAGPLEEDDLEPLTLAPAPAPRPPQDLIGLRLAQEKALKRQLEEEQKLKPGGVGAPSSSSPSPSPSARPGPPPSEEAMDFREEGPECETPGIFISMDDDSGLTEAALLDSSLEGPLPKETAAGGLTLKEERSPQTLAPVGEDAMKTPSPAAEDAREPEAKGNS Symplekin_1C sequence ------HHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHH----HHHHHHH----HHH----------HHHH-------------------------------------HHHH-------HHHHHHHHHHHH--------HHHHHH--------HHHHHHHHHHHHHHHHHH------------------HHHHHHHHHHHHHHHHHH-----------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHH---------HHHHHHH------HHHHHHHHHH-----HHHHHHHHHHHHHH-----HHHHHHHHHHHH---HHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHH-----------------------HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHH-----HHHHHHHHHHH-------HHHHHHHHHHHHH-----EEEHH------HHHHHHHHHHHH---HHHHHHHHHHHH---------------HHHHHHHHH--------HHHHHHHHHHHH-------HHHHHHHHHHHH-----HHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHH----HHHHHHHHHHHH----HHHHHH---HHHHHHHHHH-HHHHHHHHHHHHH----------HHHHHHHHH----------------------------------------HHHHHHHHHHHHHHHHH--------------------------------------------------------HHHH--------------------------------------------------------- Symplekin_1C psipred -------HHHHHHHHHHHHHHHHHH--------HHHHHHHHHHHH--HHHHHHH---HHHHHH------HHHHHHH-----------------------------------------------HHHHHHHHHHHHHH---HHHHHHHHH-----------HHHHHHHHH-------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHH-----HHHHHHHHHH-----HHHHHHHHHHH-----HHHHHHHHHHHHH-----HHHHHHHHHHHH----HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHH----------------------HHHHHHHHHHHHHHH---HHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHH-----HHHHHHHHH----HHHHHHHHHHHHH------HHHHHHHHHHHHH-----EEEEHHHH---HHHHHHHHHHHH---HHHHHHHHHHHH---------------HHHHHHHHHH-------HHHHHHHHHHHH-------HHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHH-----HHHHH---HHHHHHHHHH-HHHHHHHHHHHHHH---------HHHHHHHH--------------------------------------------------------------------------------------------------------EEE-------------------------------------------------------------------- Symplekin_1C prof ------HHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHH---HHHHHHHHHHHHHHHH-------HHHH--------------------------------------------------HHHHHHHHHHH------HHHHHH---------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHH-------------HHHHEEEEEE----HHHHHHHHHHHHH----HHHHHHHHHHHHHHH---------HHHHHHHHHHHHHHHH------HHHHHHHHHH----HHHHHHHHHHH------HHHHHHHHHHHH-----HHHHHHHHHHH-----HHHHHHHHHHHHHH------HHHHHHHHHHHHHHHH----------------------HHHHHHHHHHHHHH-----HHHHHHHHHH----HHHHHHHHHH---HHHH-----HHHHHHHH-------HHHHHHHHHH-------HHHHHHHHHHHH-----EEEEEE------HHHHHHHHHHHH----HHHHHHHHHH----------------HHHHHHHHH---------HHHHHHHHHH---------HHHHHHHHHHH-----HHHHHHHHHHHHHH----HHHHHHHHHHHH---E-----HHHHHHHHHHHH----HHHHHHHHHHHHHHHHHH---HHHHHHHHHHH---------HHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Symplekin_1C jnet -----HHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHH----HHHHHHH----HHHHH--------HHHH--------------------------------------HHHHHH----HHHHHHHHHHHHHH-----HHHHHHH----------HHHHHHHHHHHH---------------------------------------------------------------------------------------HHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHH------HHHHHHHHH-----HHHHHHHHHH-----HHHHHHHHHHHHHH-----HHHHHHHHHHHHH---HHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHH----------------------HHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHH----HHHHHHHHHHHHH------HHHHHHHHHHHH------HHHHHHHH---HHHHHHHHHHHH---HHHHHHHHHHHH---------------HHHHHHHH---------HHHHHHHHHHHHH------HHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHH---HHHHHHHH--HHHHHHHHHH--HHHHHHHHHHHH----------HHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Symplekin_1C sable ------HHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHH--HHHHHHHHHHHHHHHH-------HHHHHHH---------------------------------HHHHHHHHHH---HHHHHHHHHHHHHH--HHHHHHHHHHHHHH------HHHHHHHHHH---------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------HHHHHHHHHHHHHHHH--HHHHHHHHHHHH-----HHHHHHHHHHH---HHHHHHHHHHHHHHH-----HHHHHHHHHHHHHH-HHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHH----------------------HHHHHHHHHHHHHHHH--HHHHHHHHHHHH---HHHHHHHHHHHHHHHH------HHHHHHHHH-----HHHHHHHHHHHH------HHHHHHHHHHHHH----HHHHHHHH----HHHHHHHHHHHH---HHHHHHHHHHH----------------HHHHHHHHH--------HHHHHHHHHHHHH------HHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHH-----HHHHH--HHHHHHHHHHHHHHHHHHHHHHHH------------HHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Symplekin_1C proteus ----HHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHH-----HHHHHHH-----------------HH--------------------------HHHHHHH-------HHHHHHHH-------HEEEE-------H--HHHHHH---HH----HHHHHHHHHHHHHHHHH--------E----------EEEE----EEEE--------E----------------------------------E------EEEEE---------HHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHH-----HHHHHHHHHHH------HHHHHHHHHHH---HHHHHHHHHHHHHHHH---HHHHHHHHHHHH-----HHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHH----HHHHH-------------HHHHHHHHHHHHHH----HHHHHHHHHHHHH-HHHHHHHHHHH-HHHHHH-----HHHHHHHH-----HHHHHHHHHHHHH------HHHHHHHHHHHH------EEEEEE-----HHHHHHH-HHHH---HHHHHHHHHHHH---------------HHHHHHHHH--------HHHHHHHHHHHH-------HHHHHHHHHHHHH----HHHHHHHHHHHHHH-H-HHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHH------EEEE--HHHHHHHHHH-H-HHHHHHHHHHHH---------HHHHHHH--------HH--------------------------HHHHHHHHHHHHHHHHHHHHHHHH--------------------------HHHHHHHHH--------EEEEE------HHHHHHHH--------HHHH----------------HHHHHH-------HHH---------- Symplekin_1C sspro4 --------HHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHH---HHHHHHHHHHHHHHHHH-----HHHHHHHH---------------------------------HHHHHHHHHH---HHHHHHHHHHHHHH--HHHHHHHHHHH----------HHHHHHHHHHH------------------------------------------------------------------------------HHHH---HHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHH----HHHHHHHHHH-----HHHHHHHHHHH---HHHHHHHHHHHHHHHH---HHHHHHHHHHHHHH---HHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHH---------------------HHHHHHHHHHHHHHH---HHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHH----HHHHHHHHH----HHHHHHHHHHHHH------HHHHHHHHHHHHH-----EEEEHHHH---HHHHHHHHHHHHH--HHHHHHHHHHHH---------------HHHHHHHHHH-------HHHHHHHHHHHHH------HHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHH-HHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Symplekin_1C psspred ------HHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHH---HHHHHHH-----------------HHHHHH---------------------------------HHHHHHH------HHHHHHHHHHHHHH-----HHHHHH----------HHHHHHHHHHHHHHHHHH------HHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHH----------HHHHHH------------HHHHH-----HHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHH----HHHHHHHHHHH-----HHHHHHHHHHH--HHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHH---HHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHH------HH--------------HHHHHHHHHHHHHH----HHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHH----HHHHHHHHH----HHHHHHHHHHHHH------HHHHHHHHHHHHHH---HHHHHHHHHH--HHHHHHHHHHHHH--HHHHHHHHHHHHH--------------HHHHHHHHHH------HHHHHHHHHHHHHH------HHHHHHHHHHHHH-----HHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHH-HHHHHHHHH--HHHHHHHHHH-HHHHHHHHHHHHHH---------HHHHHHHHHH----HHHHH-------------------------HHHHHHHHHHHHHHHHHHHHHHHH-------------------------------------------EEEEE-------HHHHHHH----------------------------------------------------- Symplekin_1C spineX ------HHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHH----HHHHHH-------------------------------------------------EEE------HHHHH-------HHHHHHHHHHHHH---------HHH-----------------------------------------------------------------------------------------------------------EEEEEE---------HHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHH------HHHHHHHHHHH------HHHHHHHHHHH--HHHHHHHHHHHHHHHH-----HHHHHHHHHHH-----HHHHHHHHHHHHH-------HHHHHHHHHHHHHHH-----------------------HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHH-----HHHHHHHHHHH-------HHHHHHHHHHH-------EEEEE------HHHHHHH-HHH----HHHHHHHHHHH----------------HHHHHHHHH--------HHHHHHHHHHHH-------HHHHHHHHHHHHH----HHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHH---HHHHHHHHH------------E------------------------------------------EE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Symplekin_1C raptorxss ------HHHHHHHHHHHHHHHHHHH--------HHHHHHHHHHH---HHHHHHH---HHHHHHH-------HHHHH--------------------------------------HHH------HHHHHHHHHHHH----HHHHHHHHHHH-------------HHHHHH----------------HH-------H------------------HHH------------------------------------------HHHHH-------HHHHHHHHHHHHHHHHHH---------HHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHH---HHHHHHHHHHHH-----HHHHHHHHHH----HHHHHHHHHHHHHHHH-----HHHHHHHHHHHH---HHHHHHHHHHHHHH-------HHHHHHHHHHHHHHH------HH--------------HHHHHHHHHHHHHH----HHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHH----HHHHHHHHH-----HHHHHHHHHHH-------HHHHHHHHHHHH-H---HHEHHHHH----HHHHHHHHHHH----HHHHHHHHHHHH---------------HHHHHHHHHH-------HHHHHHHHHHHH-------HHHHHHHHHHHH------HHHHHHHHHHHHH-HHHHHHHHHHHHHHHHH-H---HHHHHHHHHHHHHH---HHHHHHE--HHHHHHHHHH-HHHHHHHHHHHHHH---HH---HHHHHHHHHH-----------------------------------------------------HH------------------------------------------------EEE-----------HH-----------------------------------H------------------- Symplekin_1C SPARROW -------HH-HHHHHHHHHHHHHHHH-----HHHHHHHHHHHHH---HHHHHHHH---HHHHH-------HHHHHH-----------------------------------------------HHHHHHHHHHHHHH------HHHH---------------HHHHHH---------------------------------------------------------------------------------HHH------------------HHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHH---HHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHH--------HHHHHHHHHHHHHHH----HHHHHHHHHHH-----HHHHHHHHHH---HHHHHHHHHHHHHHHH-----HHHHHHHHHHHHH---HHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHH-----HH---------------HHHHHHHHHHHHHHH---HHHHHHHHHHH----HHHHHHHHHHHHHHHHH-----HHHHHHHHH-----HHHHHHHHHHH-------HHHHHHHHHHHH-----HHHHHHHH----HHHHHHHHHHH----HHHHHHHHHHHH---------------HHHHHHHHHH-------HHHHHHHHHHHH-------HHHHHHHHHHHH------HHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHH-----HHHHHH--HHHHHHHHHH------HHHHH-------------HHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Symplekin_1C *SPARROW --HHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHH--------------------HHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------------------------HHHHHHHHHHHH-HHHHHHH-H------HHH-----------------HHHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHH-HH-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHH-HHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHH----HHHHHHHHHHHHHH----HHHHHHHHHHHHHHH----EEE-----H--HHHHHHHHHHHHH--HHHHHHHHHHHHH--------------HHHHHHHHHHH-HHH--HHHHHHHHHHHHHH--EE-HHHHHHHHHHHHHH----HHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHH-----EEEEEE-HHHHHHHHHH-HHHHHHHHHHHHH--HHHHHHHHHHHHHHHHH-----------------HH---------------------H-HHHHHHHHHHHHHH----------------------------HHHHHHHHHH--------EEEEE---HH-HHHHHH-HH------HHHHHH-----------------HHH-------------------- Symplekin_1C HMMSTR ------HHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHH-----HHHHHHH----HHH--------HHHHHHHHH-------------------------------HHHHHHHHHHH----HHHHHHHHHH------H-HHHHHHH--HHHH---HHHHHHHHHHHHHHHHH-------HHH---------EEE-----EEE------------------------------------------------------E----------HHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHH-----------HHH-------HHHHHHHHHHH-----HHHHHHHHHHHHH----HHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHH--------------HHHHHHHHHHHHHH----HHHHHHHHHHHHH-HHHHHHHHHHH--HHHHH-----HHHHHHHH-----HHHHHHHHHHHHH------HHHHHHHHHHHHH----------------HHHHHHHHHHHHH--HHHHHHHHHHHH---------------HHHHHHHHH--------HHHHHHHHHHHHH------HHHHHHHHHHHHH----HHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHH-------EEE---HHHHHHHHHH-HHHHHHHHHHHHH----------HHHHHHHH-----------------------------------HHHHHHHHHHHHHHHHHHHHHHHH---------------------------HHHHHHHH---------EE--------HHHHHHHH-------------------------------HHH-----HHHHHHHHHHH---- Symplekin_1C porter --------HHHHHHHHHHHHHHHHH-----EHHHHHHHHHHHH----HHHHHH----------------HHHHHHHHH---------------------------------HHHHHHHHH----HHHHHHHHHHHH--HHHHHHHHHHH--HHHH--HHHHHHHHHHHHHHHHHH------HHHHH------HHHHH-HHHHHHHHHHHHHH--HHHHHH---------HHHHHH-----------------------------------HHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHH--------HHHHHHHH-----HHHHHHHHHH------HHHHHHHHHHHHH----HHHHHHHHHHHHH----HHHHHHHHHHHHHH--HH-HHHHHHHHHHHHHHHHH----HHHH--------------HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHH---HHH-----HHHHHHHH-----HHHHHHHHHHHH-------HHHHHHHHHHHHH-----EEEEE------HHHHHHH-HHHHH--HHHHHHHHHHHHH--------------HHHHHHHHH--------HHHHHHHHHH---------HHHHHHHHHHHHH----HHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHH---H-HEEEE--HHHHHHHHHH-HHHHHHHHHHHH----------HHHHHHHHH-----------------------------------HHHHHHHHHHHHHHHHHHHHHHHH---------------------------HHHHHHH---------EEEEEE------HHHHHH---------HHHH------HHH---------HHHHH-----HHHH---------- Symplekin_1C spine ----HHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHH----HHHHHH-----------------HHHHHHH-----------------------------------HHHHHHH-----------EE------------HHHHHH--------HHHHHHHHHHHHHHHHHH------HHHHHHHH--------HHHHHHHHHHHHH----EEEE-------HHHHHHHHH------EEE-------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHH-------EEEEEE-----HHHHHHHHHHHHHHH--------HHHHHHHH-----HHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------EEE-------------HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHH----------HHHHHHH------HHHHHHHHH---------HHHHHHHHHHHH------EEEEE------HHHHHHHHHHHHH---HHHHHHHHHHH-----------------HHHHHHH--------HHHHHHHHHHHHH------HHHHHHHHHHHHHH----EEHHHHHHHHHH-------HHHHHHHHHHHHHHH---HHHHHHHHHH-------EEEEEE----HHHHHH----HHHHHHHHHHH-------------HHHHHHH-------------------------------------HHHHHHHHHHHHHHHHHHHHHH--------------------------HHHHHHHH---------EEEE--------HHHHHHH---------------EE----------------------HHHHHHHHHH---- Symplekin_1C nnssp --HHHHHHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHH----HHHHHHH---------------HHHHHHHH-------------------------------------HHHHHHH--HHHHHHHHHHHHHH---------------------HHHHHHHHHHHHHHHHHH-----------------HHHHHHHHHHHHHHHHHH---EEEEE-------HHHHHHHHHHH---------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHH-----------EEEEEEE-----HHHHHHHHHH----------HHHHHHHHHH-HHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------EEEEEE-----------HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHH------------HHHHHHHHH------EEEEEEEE---------HHHHHHHHHHHHHH---EEEEEE------HHHHHHHHHHHHH--HHHHHHHHHHHH------------------EEEEEE--------HHHHHHHHHHHHHHH----HHHHHHHHHHHHHH----HHHHHHHHHH----------HHHHHHHHHHHHH---HHHHHHHHHHHHH-----EEEEEEE-HHH--------HHHHHHHHHHHHHH---------HHHHHHHHHH---------------------------------HHHHHHHHHHHHHHHHHHHHHHHHH-------------------------HHHHHHHHHH--------EEEEE-----HHHHHHHHHHH--------------------------------------------------- Symplekin_1C pssfinder ----HHHHHHHHHHHHH-HHHHHH-----HHHHHHHHHHHHHH----HHHHHH-----------------HHHHHH-------------------------HHH-------HHHHHHH-------HHHHHHHHHHHH------HHHHHHH--------HHHHHHHHHHHHHHHHH------HHHHH-------HHHHHHHHHHHHHHHH-----EEEEE--------HHHHHHH---------EE-----------EEHHHH-HHH----HHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHH---------EE-EEE------HHHHHHHHHHHHHHH---EE--HHHHHHHHH-----HHHHHHHHH-------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------EEEEEE-----------HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHH----------HHHHHHHH----HHHHHHHHHH---------HHHHHHHHHHHHHH----EEEE-------HHHHHHHHHHHHH---HHHHHHHHHHH-----------------HHHHHH----------HHHHHHH-HHHH------HHHHHHHHHHHHHH----HHHHHHHHHH---------EEHHHH-HHHHHHHHH-HHHHHHHHHHH-------HHH------HHHHHHHH--HHHHHHHHHHHH-----HHHH---HHHHHHHH----------------------------------------HHHHHHHHHHHHHHHH-----------------------------HHHHHHHH---------EEEEE-----HHHHHHHHH--------------HHHHHH--HHHHHH------------HHHHH-------- Symplekin_1C sspal ----HHHHHHHHHHHHHHHHHHHHHH----HHHHHHEEEEEEE---HHHHHHHHH---------------HHHHHHHHH----HHHHHHHHH----------------------HHHHH----------EEEEEEEE--HHHHHHHHHH------HHHHHHHHHHHHHHH--------------------------EEEE--EEEE-------EEEEEEE-------HHHHH---------EEEEE---------HHHHHHHHHHHH---HHHHHHHHH-HHHHHHHHH---HHHHHHHEEEEEEE-----------HHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHH-----------EEEEEEE------HHHHHHHHHHHH----EEEEHHHHHHHHHHH----EEEEEEEEEEE--HHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHH------EEEE-----------HHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHH-HHHHHHHHHHH---------HHHHHHHHH----HHHHHHHHHH----------HHHHHHHHHH------EEEEEHHHHHHHH-HHHHHHHHHHH-----HHHHHHHHH----------------HHHHHHHHH---EEEEEEEEEE----------HHHHHHHHHHHHHHHHH-----HHHHHHHHHHEEE------HHHHHHHHHHH-----HHHHHHHHH--------EEEEEEEE--HHHHHHHHH-HHHHH-HHHHHHHHH--------HHHHHHHHH-------------------------------------HHHHHHHHHHHHHHHHHH------------------------------HHHHHHHHH--------EEEEE-------HHHHH----------------EEEE------------HHHHH----HHHHHHHHHHH--- Symplekin_1C ssp ---------HHHHHHHHHHHHHHHH----------HHHHHHH-------HH------------------HHHHHHH----------------------------------HHHHHHHHH--------HHHHHH------HHHHHHHHH----------HHHHHHHHHHHHHH-HE-----------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHH-------HHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHH----------HHHHHHHHHHHHH--------HHHHHHH------HHHHHHHHH-------HHHHHHHHHHHH-------HHHHHHHHHHH------HHHHHHHHHHHHH----HHHHHHHHHHHHHHHHH----HHHHH-----------------H-HHHHH--------HHHHHHHHHHH--HHHHHHHHHHHHHHHHH-------HHHHHH-------HHHHHHHHH---------HHHHHHHHH------------------------------HH----HHHHHHHH-HH-----------------HHHHHHH----------HHHHHH-----------HHHHHHHHHHHH------HHHHHHHHHHHH----HHHHHHHHHHHHH---------HHHHHHHHHH--------------HHHHHHHHH----------HHHH-----------HHHHHHH----------------------------------------HHHH---HHHHHH------------------------------------HHHH------------EEE-------HHHHH---------------------------------HH--------------------- Symplekin_1C sspred ------HHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHH-HHHHHHH----------------HHHHH------------------------------------HHHH--------HHHHHHHHHHHHH---HHHHHHHHHH-------------HHHHHH---------------------------------HHHH------------------------HHH---------------HHHHHH-----------------HHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHH-----HHHHHHHHHH-----HHHHHHHHHH-----HHHHHHHHHHHHHH-----HHHHHHHHHHHH----HHHHHHHHHHHHHH------HHHHHHHHHHHHHHHH---------------------HHHHHHHHHHHHHHHH---HHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHH-----HHHHHHHHH-----HHHHHHHHHHHH------HHHHHHHHHHHHH----HHHHHHHH----HHHHHHHHHHH----HHHHHHHHHHHE---------------HHHHHHHHH--------HHHHHHHHHHHH-------HHHHHHHHHHHH------HHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHH----HHHHHH---HHHHHHHHHH-HHHHHHHHHHHHHH--------HHHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ Symplekin_1C netsurfp ------HHHHHHHHHHHHHHHH-HHH-----HHHHHHHHHHHHH---HHHHHHHHHHHHHHHHH--------HHHHH-------------------------------------HHHHH----HHHHHHHHHHHHH---HHHHHHHHHH---------------HHHHHH--------------------------------H-HHH----------------------------------------HHHHHH-----------------HHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHH-HH------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------HHHHHHHHHHHHHH---HHHHHHHHHHHHH----HHHHHHHHHHH--HHHHHHHHHHHHHHHHH----HHHHHHHHHHHHH---HHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHH----HHH--------------HHHHHHHHHHHHHHHH--HHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHH----HHHHHHHHH-----HHHHHHHHHHHHHH----HHHHHHHHHHHHH------EEEEEE-----HHHHHHHHHHHH--HHHHHHHHH-HHH--------------HHHHHEHHH--------HHHHHHHHHHHHH------HHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHH--HH---HHHHHHHHHHHHHH-HHHHHHHHHH---------HHHHHHHHH---------------------------------------------HHHHHH----------------------------------------------------EE----------HHHH------------------------------------------------------- Symplekin_1C soprano ------HHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHH----HHHHHHH----HHH---------HHHHHH------------------------------------HHHHHHH----HHHHHHHHHHHHH----HHHHHHHHH---------HHHHHHHHHHHHH---------------------------------------------------------------------------------------HHH---------HHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHH-----HHHHHHHHHH-----HHHHHHHHHHH----HHHHHHHHHHHHHH-----HHHHHHHHHHHH----HHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHH----------------------HHHHHHHHHHHHHH----HHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHH-----HHHHHHHHH-----HHHHHHHHHHH-------HHHHHHHHHHHHH-----EEEEH------HHHHHHHHHHHH---HHHHHHHHHHHH---------------HHHHHHHHH--------HHHHHHHHHHHH-------HHHHHHHHHHHHH-----HHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHH-----HHHHH---HHHHHHHHHH-HHHHHHHHHHHHH----------HHHHHHHH-----------------------------------------H----HHHHHH--HH------------------------------------------------EEE--------HHHHH------------------------------------------------------- Symplekin_1C consensus MADGVDHIDIYADVGEEFNQEAEYGGHDQIDLYDDVISPSANNGDAPEDRDYMDTLPPTVGDDVGKGAAPNVVYTYTGKRIALYIGNLTWWTTDEDLTEAVHSLGVNDILEIKFFENRANGQSKGFALVGVGSEASSKKLMDLLPKRELHGQNPVVTPCNKQFLSQFEMQSRKTTQSGQMSGEGKAGPPLAGPPNRGDRPPPPVLFPGQPFGQPPLGPLPPGPPPPVPGYGPPPGPPPPQQGPPPPPGPFPPRPPGPLGPPLTLAPPPHLPGPPPGAPPPAPHVNPAFFPPPTNSGMPTSDSRGPPPTDPYGRPPPYDRGDYGPPGREMDTARTPLSEAEFEEIMNRNRAISSSAISRAVSDASAGDYGSAIETLVTAISLIKQSKVSADDRCKVLISSLQDCLHGIESKSYGSGSRRERSRERDHSRSREKSRRHKSRSRDRHDDYYRERSRERERHRDRDRDRDRERDREREYRHR CPSF6_3 sequence -------------------------------------------------------------------------------EEEEEEE-------HHHHHHHHHH------EEEEEEE---------EEEEE---HHHHHHHHHH-----------EEE------HHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHH---------HHH-------------HHHHHHHHHHHHH--------HHHHHHHHHHH-------------------------------------------HHHHHHHHHHH----------HHHHHHHHH--- CPSF6_3 psipred -------------------------------------------------------------------------------EEEEEEE-------HHHHHHHHHH-----EEEEEEEEE--------EEEEEE--HHHHHHHHHH----------EEEEEE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHH------------EEEE-------------------------------------------------------------------------------- CPSF6_3 prof -------------------------------EE-----------------------------------------------EEEEE-------HHHHHHHHHHHH------EEEEEE---------EEEEE----HHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EE---------------------------------------------------------------------------------- CPSF6_3 jnet ---------------HHH--------------HHH---------------------------------------------EEEEEE-------HHHHHHHHHH------EEEEEE----------EEEEE---HHHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHH---------HHHHHHH----------HHHHHHHHHHHHHH----------EE---HHHHH-------------------------------------------HHHHHHH-----------------HHH---- CPSF6_3 sable --------EEE---------------------------------------------------------------------EEEEEE-------HHHHHHHHHHH-----EEEEEEE--------EEEEEEE--HHHHHHHHHH-----------EEE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHH----------------------------HHHHHHHHHHHHHH-----------------------------------------------------------HHHHHHHHHHHHHHH-------------HHHH--- CPSF6_3 proteus ---------------HHH--HHH--------HHH-------------------------------------EEEEE---EEEEEE----E----HHHHHHHHH----HHHHHHHH----------EEEEEE--HHHHHHHHHH-----------------HHHHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHH------HHHHHHHH----------HHHHHHHHHHHHHH-H---HHHHHHHHHHHHHHH--HHH------------------------------------HHHHHHHHHHHHH-------HHHHHHHHHH--- CPSF6_3 sspro4 -------EE-----------------------------------------------------------------------EEEEE--------HHHHHHHHHHH----EEEEEEEE--------EEEEEEE--HHHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH------------EE-----------------------------------HHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-- CPSF6_3 psspred ----------------HHHHHH---------------------------------------------------------EEEEEE--------HHHHHHHHHHH------EEEEEE---------EEEEEE--HHHHHHHHHH-----------EEE--------HHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHH--------HHHHH-----------HHHHHHHHHHHHHHH-----HHHHHHHHHHHHH-------------------HHHHHHHHHHHHHHHH--HHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH- CPSF6_3 spineX ---------EE---------------------H-----------------------------------------------EEEEE--------HHHHHHHHHH------EEEEEEEE--------EEEE----HHHHHHHHH------------EE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH--------------------------HHH--HHHHH-----------------------------------HHHHHHHHHHHHHHHHHHHHHHHH--HHHHHHHHH-------------------HHHHH--- CPSF6_3 raptorxss ---------------HH---------------------------------------------------------------EEEEEEEE-----HHHHHHHHHH----EEE--EEEE--------EEEEE----HHHHHHHHHH----E----E-EE--------HHH-HHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHH----H---HHHHHH----H---------HHHHHHHH------------E----HHHHH-----------------------H---------------HHHHHHHH-HHHH----HH--------HHHH---- CPSF6_3 SPARROW -------E--------HHH-------------------------------------------------------------EEEEEE-------HHHHHHHHHHH---EE--EEEEE------E--EEEE----HHHHHHHHHH-----------EE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H------------------------------------------------H--------------------HHH-------------------HHHHH--- CPSF6_3 *SPARROW ------EEEEEE-HHHHHHH-----HHHHHHHHHHHHH-----------------------------------------EEEEEEE-EEEEE-HHHHHHHHHHH---EEEEEEEEE------EE--EEEEEEEHHHHHHHHHHH---EE---EEEEEEE--H-HHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHH-HHHHHHHH-HH-H--HHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHH-------------HHHHHH-------H-H--H-----HHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHH CPSF6_3 HMMSTR ------EEEEH----HH---------------------------------------------------------------EEEEEE-------HHHHHHHHH-----EEEEEEEEE---------EEEEEE--HHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHH------------------------HHHHHH-E------------------------HH--------------------------------------------HHHHHHHHHHH-----------HHHHHH-- CPSF6_3 porter ----HHHHHHHH--HHHHHHHH-------------------------------------------------EE------EEEEEEE-------HHHHHHHHHH-----EEEEEEE----------EEEEEE--HHHHHHHHHH------------EE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHH--HHHHHHHH--------HHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHH----------------HHH-------HHHHHH-------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--- CPSF6_3 spine -------HHHHH-----------------------------------------------------------EEEE----EEEEEE---------HHHHHHHHH-------EEEE-----------EEEEE------HHHHHHH-------------------HHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHH-------HHHHHHH---------HHHHHHHHHHHH----------EEEEE-----------------------------------------------HHHHHHH-HHHHHHH-HHHHHHHHHHHHHHHHH- CPSF6_3 nnssp ------EEEEEEE--HHHHHHHHH----EEEEE--------------------------------------EEEEEE--EEEEEEE-------HHHHHHHHHHH-HHHHHHHHHHHHHH------EEEEEE--HHHHHHHHHH-----------------HHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHH-----HHHHHHHHHHHH-------HHHHHHHHHHHHH----HHHHHHHHHHHHHHH-------------HHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-- CPSF6_3 pssfinder ---------EEE---HHHHHHH-------EEEE--------------------------------------EEEEE----EEEEE---------HHHHHHHHHH------EEEEE----------EEEEE------HHHHHHH------------------HHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHH-----HHHHHHHHH---------HHHHHHHHHHHH---------EEEEEE--HHHHH--------------------------------------------------------------------HHHHHH CPSF6_3 sspal -------HHHHHHHHHHHHHHHHH-----------------------HHHHHHHHH---------------EEEEEEE-EEEEEEE------HHHHHHHHHHH------HHHHHHHHHH------EEEEEEEHHHHHHHHHHHH----------EEEE-HHHHHHHHHH--------------------------------------------------------------------------------------------EEEE-------------------------------------------------------------------------HHHHHHHHH-------HHHHHHHHHHH-----HHHHHHHHH---------HHHHHHHHHHHHHH---------------------------------------------------------------------------- CPSF6_3 ssp ----------HH---HH-----------------------------------------------------------------------------HHHHHHHH---------EE---------------EE------HHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ CPSF6_3 sspred --------------------------------------------------------------------------------EEEEEE-------HHHHHHHHHH--------EEEEE--------EEEEEE---HHHHHHHHHH-----------EEEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H------------HHHHHH---- CPSF6_3 netsurfp ------------------------------EEE------------------------------------------------EEEEE-------HHHHHHHHHHH---EEEEEEEEE---------EEEEEE--HHHHHHHHHH---------EEEEE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E---------------------HHHHHHHHHH---------------------------H--------------------------------------HH------H-H------------------- CPSF6_3 soprano ----------------H---------------------------------------------------------------EEEEEE-------HHHHHHHHHH------EEEEEEE---------EEEEEE--HHHHHHHHHH-----------EE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH---------HHH-------------HHHHHHHHHHHH---------------------------------------------------------------HHHHHH-HHHH--------------HHHHH--- CPSF6_3 consensus MQEIIASVDHIKFDLEIAVEQQLGAQPLPFPGMDKSGAAVCEFFLKAACGKGGMCPFRHISGEKTVVCKHWLRGLCKKGDQCEFLHEYDMTKMPECYFYSKFGECSNKECPFLHIDPESKIKDCPWYDRGFCKHGPLCRHRHTRRVICVNYLVGFCPEGPSCKFMHPRFELPMGTTEQPPLPQQTQPPAKRTPQVIGVMQSQNSSAGNRGPRPLEQVTCYKCGEKGHYANRCTKGHLAFLSGQ CPSF4_3 sequence --------------HHHHHHHHH------------------------------------------------HH-------------------------------------------------------------------------------------------------------------------------------------------------EE----------------------- CPSF4_3 psipred --EEE-----EEEEEHHHHHHHH----------------EE------------------------EEEHHHHHHH-------EEE----------EEEEE-----------EEE----------HHH----------------HHHHHHHHH----------------------------------------------------------------EEEEE---------------------- CPSF4_3 prof --------------HHHHHHHHH----------------------------------EE-----EEEE--------------------------EEEEEE---EE------EEEE---------HHHHH-----------------HHHHHH----------------------------------------------------------------EEEEE---------------------- CPSF4_3 jnet --------------HHHHHHH-------------------HHHHH---------------------E-HHH-------------------------EEE-------------------------------------------------HH----------------------------------------------------------------------E---------------------- CPSF4_3 sable --------------HHHHHHHH-------------------------------------------EEE-HHH-----------------------HHHHHHH---------EEE--------------------------------------------------------------------------------------------------------EE----------------------- CPSF4_3 proteus -HHHHHHHHHHHHHHHHHHHHH---------------HHHHHHHH--------------E---EEEEEEE--E-EEE---EEEEE----HH----HHHHHH------------------------HH----------HHH--EE------H------------------------------------------------------------------EEEE---------------HHHH--- CPSF4_3 sspro4 --------------HHHHHHHHH---------------------------------------------HHHHH---------------------------------------------------HHHH--------------------HHHHH------------------------------------------------------------------E----------------------- CPSF4_3 psspred --H-----------HHHHHHHHH---------------HHHHHHHHH---------------HHHHHHHHHHH---------------------------------------------------------------------------HHHHH------------------------------------------------------------------------------------------ CPSF4_3 spineX ----------------HHH-------------------EEEEEE-------------------------H--------------------------EE-------------E----------------------------------E---------------------------------------------------------------------EEEE----------------------- CPSF4_3 raptorxss -HHHHH-HH-----HHHHHHHHH----------------EEE--------------E--------EE-HHHH---------------------------H------------E--------EE--HHH-----------------------------------------------------------------------------------------EEEE-----------------HH--- CPSF4_3 SPARROW --------------HHHHHHHH-------------------------------------------HHHHHHHH-----------------------HHH----------------------------------------------------------------------------------------------------------------------EEE--------HH------------- CPSF4_3 *SPARROW HHHHHHHHHHEEEEHHHHHHHHH---------------EEHHHH-----------HHHH-----HEEHHHHHHHH-------EEE----H-H---EEEEE-----------HHH----H--------------------HHHHHHHH---H---------------------------------------------------------------HHH--H--------E-------------- CPSF4_3 HMMSTR ---EEE--------HHHHHHHHH---------------HHHHHHH---------------------E-HHHH------HHH---E---------E-HHHHHH----E-----E-------------------------------------------------------------------------------------------------------EEEE----------------EEE---- CPSF4_3 porter --EEEE--------HHHHHHHHH---------------EEEEEHHHH----------------HHHHHHHHHH---------------------HHHHHHH----------E------------------------------------HHH---------------------------------------------EEEE-----------------EEE--------------HHHH----- CPSF4_3 spine HHHHHHH--------HHHHH------------------HHHHHHHH-------------------EEE---------------EE-----------EE--------------EE-------------------------------EEEE---------------------------------------------EEEE------------------EEEE----------------EEEE--- CPSF4_3 nnssp --HHHHHHHHHHHHHHHHHHHHH-------------HHHHHHHHHHHH---------------EEEEEEEEEEEEEE---EEEEEE---------------------------------------------------------EEEEEEE-------------------------------------------EEEEEEE------------------------------------------- CPSF4_3 pssfinder HHHHHHH---EEEEEEEEHHHHH--------------EE--HHH-------------EEE----EEEEEEEE-----------EEE----------EEEE-----------EEEE-----EE---------------------EEEEEEEEEEE---------------------------------------EEEEEEE----------------EEEEE--------------EEEEEE-- CPSF4_3 sspal HHHHHHHHHHHHHHHHHHHHHHH---------HHHHHHHHHHHHHH------------------EEEEEEEEE------HHHHHHHHH-------EEEEEEE---------------------------------------EEEEEEEE-EEEEEEE------------------------------------EEEEEEE----------------EEEE----------------------- CPSF4_3 ssp --------------HHHHH---------------------EEEHHH-------------------------HH-----------------------HE------------------------------------------------------------------------------------------------------------------------------------------------- CPSF4_3 sspred ---------------HHHHHHH--------------------------------------------HHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------- CPSF4_3 netsurfp --------------HHHHHHHH--------------------EH----------------------E-HHHHH------------------------HHH-------------------------HHH-----------H---------HHH------------------------------------------------------------------EE----------------------- CPSF4_3 soprano --------------HHHHHHHHH-----------------HHHH---------------------EEEHHHH------------------------EE-----------------------------------------------------------------------------------------------------------------------EEE----------------------- CPSF4_3 consensus MPSSPLRVAVVCSSNQNRSMEAHNILSKRGFSVRSFGTGTHVKLPGPAPDKPNVYDFKTTYDQMYNDLLRKDKELYPSGLPFKNPPCGPPWKVLRVARAQEACHPVQCTHWLLCLCESLVSIPGARRIVHGLVPVPPMAVGVVRRTDTVWGSP SSU72_2 sequence ------EEEEEE-----HHHHHHHHHHH----EEEE-----EE----------EE-----HHHHHHHHHH-------------------HHHH------------------EEEEEEEEE-----EEEEEE-------EEEEEEE-------- SSU72_2 psipred -----EEEEEEE-------HHHHHHHHH---EEEE-----EEE-----------------HHHHHHHHHHH-HHHH---------EEEHHHHHHHH---------------EEEEEE-----HHHHHHH----------EEEEEEEEEEE--- SSU72_2 prof ------EEEEEE-----HHHHHHHHHHH----EEE-----EEEE---------------HHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHH-----------EEEEEEE---HHHHHHHHH------------EEEE--------- SSU72_2 jnet ------EEEEEEE-----HHHHHHHHHH----EEEE----EEE----------EEE----HHHHHHHHHHH-HHHH-------------HHHHH---------------EEEEEEE------------------------EEE-----E---- SSU72_2 sable -----EEEEEEE-----HHHHHHHHHHH--EEEEEE----EEE---------EEE-----HHHHHHHHHHHHHHHHH----------HHHHHHHH-------------EEEEEEEEEEEE------EEEEE-------EEEEEEE-------- SSU72_2 proteus -------EEEEE-------HHHHHHHHH----EEE------E------------------HHHHHHHHHHHHHHHHH------------HHHHHHHHHHHHH-----HHHHHHHHHHHH-------EEEE--------EEEEEEE-------- SSU72_2 sspro4 ------EEEEEE-----HHHHHHHHHHHH---EEEE------------------------HHHHHHHHHHH-HHHHH-----------HHHHHHH--------------EEEEEE-----E------EEE--------EEEEEE--------- SSU72_2 psspred ------EEEEEE-------HHHHHHHHHH--EEEEE----EEEE----------------HHHHHHHHHHH-HHHHHH--------------EEEE--------EEEEHHHHHHHHHHHHH-----EEEE--------E--EEE--------- SSU72_2 spineX ------EEEEEE-------HHHHHHHHH---EEEE-----EEE-----------------HHHHHHHHH--------------------------HHHHHHH-------EEEEEE-HHH--HHHHHHHHH-------EEEEEEE--------- SSU72_2 raptorxss ------EEEEEE------HHHHHHHHHH---EEEEE----EEE---------EE------HHHHHHHHHHH-HHHHH-----------HHHHHHHH-HHH--E------E-EEEEE--E-------EEEEE------EEEEEEEE-------- SSU72_2 SPARROW -------EEEE--------HHHHHHHHH---EEEE-----EEE-----------------HHHHHHHHHH--HHHH------------------------H----------EEEE---H-HHHHHHHHHH---------EEEEEE-------- SSU72_2 *SPARROW ------EEEEEEE-----HHHHHHHHHHH--EEEEE----EEEE---------EEEE---HHHHHHHHHHH-HHHEE-----H--HHHHHHH---EE--HHHHHHHH--E-EEEEE-HHHHHHHHHHHHHH--------EEEEEEEEEEE--- SSU72_2 HMMSTR ------EEEEEE-------HHHHHHHHH----EEEEE----EEE--------EEE-----HHHHHHHHHH--HHHH--------------HHHHHHHHHHH--------HHHHHH-H---------EEE-----------EEEE--------- SSU72_2 porter ------EEEEEEE----HHHHHHHHHHH---EEEE------------------EEE----HHHHHHHHHHHHHHHH------------------HHHH------------EEEEHHHHHH-------------------EEEEEEEE------ SSU72_2 cdm ------EEEEEE-----HHHHHHHHHHH---EEEEEE----EEEEEEE--EEEEE-----HHHHHHHHH---HHHH------------------HHHH------------EEEEHHHHHH-------------------EEEEEEEE------ SSU72_2 fdm ------EEEEEE-----HHHHHHHHHHH---EEEEEE----EEEEEEE--EEEEE-----HHHHHHHHH---HHHH-------------HHHHHHHHH-HHH-----HHHHHHHHHHHHHHHH--HHHHHH---HHH-HHHHHH--------- SSU72_2 gor -----EEEEEEE-------HHHHHHHHH----EEEE----EEE-----------------HHHHHHHHHHHHHHH---------------HHHHHH--HHH----HHHHHHHHHHHHHH-------EEEE--------EEEEEEE-------- SSU72_2 spine ------EEEEEE-------HHHHHHH-----EEEE-------------------------HHHHHHHHHH----------------------EEEE--------------EEEEE---EE-------EE----------EEE----------- SSU72_2 nnssp ------EEEEEE-----HHHHHHHHHHH---EEEE-----EEE-----------------HHHHHHHHHHHHHHH---------------HHHHHHHHHHHH------HHHHHHHHHHH-------EEE--------EEEEEEE--------- SSU72_2 pssfinder -----EEEEEEEE-----------EE---EEEEEE-----EEEE---------EEEEEEEE---HHHHHH---------------------EEEE---------------EEEE------------EEEEEE-------EEEEE----EE--- SSU72_2 sspal -----EEEEEEE-------HHHHHHHHH---------EEEEEEEE---------HHHHHHHHHHHHHHHH----------------------HHHHHHHHH----EEEEEEEEEE---EEEE---------------EEEEEEE--------- SSU72_2 ssp ------EEEEEEE-------HHHHHHHH---EEEEE----EE-----------EE-----HHHHHHHHHHH---------------------EHE--------------HHHHHHHH----------------------EEEEE--------- SSU72_2 sspred ------EEEEEEE------HHHHHHHHH----EEE-----EEE-----------------HHHHHHHHHHH-HHHHH--------------------------------EEEEEEE------HHHHHHH----------EEEEEE-------- SSU72_2 netsurfp ------EEEEEE------HHHHHHHHHH----EEEE----EEEE---------EE-----HHHHHHHHHHH-HHHH----------------EEEE---------EEEEEEEEEEHHHH-----HHHHH--------HHH-EE---------- SSU72_2 soprano ------EEEEEE------HHHHHHHHHH---EEEEE----EEE----------E------HHHHHHHHHHH-HHHH--------------HHHHHH-------------EEEEEEHH-H-------EEE----------EEEEE--------- SSU72_2 consensus MAGLTVRDPAVDRSLRSVFVGNIPYEATEEQLKDIFSEVGPVVSFRLVYDRETGKPKGYGFCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGTGAPVIESPYGETISPEDAPESISKAVASLPPEQMFELMKQMKLCVQNSPQEARNMLLQNPQLAYALLQAQVVMRIVDPEIALKILHRQTNIPTLIAGNPQPVHGAGPGSGSNVSMNQQNPQAPQAQSLGGMHVNGAPPLMQASMQGGVPAPGQMPAAVTGPGPGSLAPGGGMQAQVGMPGSGPVSMERGQVPMQDPRAAMQRGSLPANVPTPRGLLGDAPNDPRGGTLLSVTGEVEPRGYLGPPHQGPPMHHVPGHESRGPPPHELRGGPLPEPRPLMAEPRGPMLDQRGPPLDGRGGRDPRGIDARGMEARAMEARGLDARGLEARAMEARAMEARAMEARAMEARAMEVRGMEARGMDTRGPVPGPRGPIPSGMQGPSPINMGAVVPQGSRQVPVMQGTGMQGASIQGGSQPGGFSPGQNQVTPQDHEKAALIMQVLQLTADQIAMLPPEQRQSILILKEQIQKSTGAP CSTF2_1 sequence ----------------EEEEE-------HHHHHHHHHH---EEEEEE-----------EEEEEE--HHHHHHHHHH---------EEEEE-------HHHHH----------------------HHHHHHHH----HHHHHHHHHHHHHHHHH-HHHHHHHHH----HHHHHHHHHHHHH---HHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HH----------HHHHHHHHHHHHHHHHHHHHHHHHH------------------------------------------------------------------------------HHHHHHHHHHHHH--HHHHH---HHHHHHHHHHHHHHHHH---- CSTF2_1 psipred --------HHH-----EEEEE-------HHHHHHHHHH---EEEEEEEEE----------EEE---HHHHHHHHHHH--------EEEEE-------HHHHH----------------------HHHHHHHHH----HHHHHHHHHHHHHH---HHHHHHHHH---HHHHHHHHHHHHH----HHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHH--HHHHH---HHHHHHHHHHHHHHHHH---- CSTF2_1 prof ----------------EEEE-------HHHHHHHHHHH----EEEEEEE------------E----HHHHHHHHHH----------EEE-----------------------------------HHHHHHHH-------HHHHH-----E----HHHHHHHHH----HHHHHHHHHH-----HHHHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHH------------HHHHHHHHHHHHH----- CSTF2_1 jnet ----------------EEEEE-------HHHHHHHHHH----EEEEEEE---------EEEEEE--HHHHHHHHHH---------EEEEEE----------------------------------HHHHHH-----HHHHHHHHHHHHHHHH--HHHHHHHHHH---HHHHHHHHHHH-----HHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHH--HHHHHH-----HHHHHHHHHHHH------ CSTF2_1 sable -----------HHHHEEEEEE-------HHHHHHHHHHH---EEEEEEEE----EEE-EEEEEE--HHHHHHHHHHH-------EEEEEEE---HHHHHHHHH-------------------HHHHHHHHHH----HHHHHHHHH---------HHHHHHHHHH---HHHHHHHHHHHHH---HHHHHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHH----HHHHHH----HHHHHHHHHHHHH------ CSTF2_1 proteus ---------------EEEEEE-------HHHHHHHHHHH--EEEEE--E------E--EEEEEE--HHHHHHHHHHH---E----E-EEE--------HHH------------------------HHHHHHH----HHHHHHHHHHHHHHH---HHHHHHHHHH-HHHHHHHHHHHHHHH---HHHHHHHHHH-------------------------------------------------------------------------------------------------------E------------------------------------EEEE-----------------------------------------------------------------------------HHHHHHHHH-HHHHHHHHHHHHHHHHHH--------------------------------------------------------------------------------------------HHHHHHHHHHHHH-HHHHH---HHHHHHHHHHHHHHHHH---- CSTF2_1 sspro4 ----------------EEEE--------HHHHHHHHHHH--EEEEEEEE---------EEEEEE--HHHHHHHHHHH--EEE--EEEEE--------HHHHHHH--------------------HHHHHHH-----HHHHHHHH----------HHHHHHHHHH----EEEEHH-HHHH----HHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHH---HHHHH-------HHHHHHHHHHHH----- CSTF2_1 psspred ---------------EEEEE--------HHHHHHHHHHH--E-EEEEEE---------EEEEEE--HHHHHHHHHHH---EE--EEEEE-----HHHHHHHHHH--------------------HHHHHHHHHH--HHHHHHHHHHHHHHHHH-HHHHHHHHHH-HHHHHHHHHHHHHH----HHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHH------------------------------------------------------------------------------------HHHHHHHHHHHHH--HHHHHH--HHHHHHHHHHHHHHHHH---- CSTF2_1 spineX --------HHH----EEEEE--------HHHHHHHH-----EEEEEEEE---------EEEEEE--HHHHHHHHHH---------EEEE------------------------------------------------------------------HHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHH----HHHHH-----H--HHHHH----------- CSTF2_1 raptorxss --------HHH-----EEEEE-------HHHHHHHHH----EEEEEEEE---------EEEEE---HHHHHHHHHH-----E---EEEEE----------HHH-------HH-------------HHHHHHH----HHHHHHHHHHHHHHHH--HHHHHHHHHH-HHHHHHHHHHHHH-----HHHHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHH--HHHHHH-------HHHHHHHHHH------ CSTF2_1 SPARROW --------HHHH----EEEEE-------HHHHHHHHHH---EEEEEEEE---------EEEEEE--HHHHHHHHHH----EE---EEEE-----------HHHH---------------------HHH------------HHHHHHHHHHHH-HHHHHHHHHHH-HHHHHHHHHHHHH-----HHHHHHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHH----HHHH---------HHHHHHHHH------- CSTF2_1 *SPARROW -------HHHHHHHHHEEEEE---HHHHHHHHHHHHHHHEEEEEEEEEE------EE---EEEEE-HHHHHHHHHHH----E---EEEEE-HHHHHHHHHHHHH--------------------HHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE-HHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHH-----HHHHHHHH------------------------------------HHHHHHHHHHHHHHHHHHHHHH----------------------------------------------------------------------------------------HHHHHHHHHHHHHHH--HHHHHH--HHHHHHHHHHHHHHHHH---- CSTF2_1 HMMSTR ----------------EEEEE-------HHHHHHHHH----EEEEEEEE------EEEEEEEEE--HHHHHHHHHHH---E----EEEEEE--------HHH-----------------------HHHHHHH----HHHHHHHHHHH-------HHHHHHHHH---HHHHHHHHHHH-------HHHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHH---HHHHH---HHHHHHHHHHHHHHH------ CSTF2_1 porter ----------------EEEEE-------HHHHHHHHHH---EEEEEEEE--------EEEEEEE--HHHHHHHHHHH--EEE---EEEE---------HHHH-------------------------EEEEE----HHHHHHHH---EEEE---HHHHHHHHH------EEEEEEHHHH----HHHHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHH----------------------------------------------H-H-HHHH-H----HHHHHHHHHHHHHHHHHHHHHHHH----HHH-----------------------------------------------HHHHHH------------------HHHHHHHHHHHHH--HHHHH---HHHHHHHHHHHHHHHH----- CSTF2_1 spine ----------------EEEE--------HHHHHHHHHH----EEEEEEE-----------------HHHHHHHHHH---------EEEE--------HHHHHH------EE-------------------------HHHHHHHHHHHHHH-----HHHHHHHH---HHHHHHHHHHHHHEE---HHHHHHHH-------EE-----------------------------------------------------------------------------------------------------------------------------------EEEEE--------------------------------------------------------------------------HHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----------------------------------------------------------------------------HHHHHHHHHHHH---------------EEEHHHHHHH----- CSTF2_1 nnssp ----------------EEEE--------HHHHHHHHHHH--EEEEEEEEE--------EEEEEE--HHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHH--------------------HHHHHHHHHH--HHHHHHHHHHHHHHH---HHHHHHHHHH-HHHHHHHHHHHHHHHH--HHHHHHHHHHH----EEEE-----------------------------------------HHHHHHHH--------------------------------------------------HHHHHHH------------------------EEEEE--------------------------------------------------------------------------HHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------------------------------------------------------------------HHHHHHHHHHHHHHH--HHHHHH--HHHHHHHHHHHHHHHH----- CSTF2_1 pssfinder ----EE-----------EEE-----HHHHHHHHHHHHH---EEEEEE-------------------HHHHHHHHHH------------------HHHHHHHH-------EE--------------HHHHHHH----HHHHHHHHHH-HHHH----HHHHHHHH--HHHHHHHHHHHHHHH---HHHHHHHHH-----------------------------------------------------------------------EE--------------EEE-------------------HHHHH--------------------------EEEEEEE---------------------------------------------------------------------------HHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------------------------------------------EE----------------------------HHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHH----- CSTF2_1 sspal ---EEEE------EEEEEEE-----HHHHHHHHHHHHHH--EEEEEEEE-------------HHHHHHHHHHHHH--------------HHHHHHHHHHHHHHH-------------------HHHHHHHHHH----HHHHHHHHHEEEEEEE--HHHHHHHHH--HHHHHHHHH-EEEEEEE-HHHHHHHHH--------------------------------------------------HHHHHHHHH-------------------------EEEEEEE------------------------------------------------EEEEEEEEEE---------------------------------------------------------------------HHHHHHHHHHHH---HHHHHHHHHHHHH--HHHHHHHHHHHHH---------------------------------EEEEEEE------EEEE-------------------------------HHHHHHHHHHHH-HHHHHHH--HHHHHHHHHHHHHHH----- CSTF2_1 ssp ----------------EEEEE-------HHHHHHHHHH------EEEE-----------EEEEE--HHHHHHHHHHH---------EEEE--------------------------------------EEE-------HHHHH----EEEE---HHHHHHHHH------HHHHHHH-------HHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHH------HH------------HHHHHH------ CSTF2_1 sspred ----------------EEEEE-------HHHHHHHHHH----EEEEEEE---------EEEEEE--HHHHHHHHHHH----E---EEEEE--------HHHHHH------------------HHHHHHHH------HHHHHHHHHHHHHHH---HHHHHHHHHH---HHHHHHHHHHH-----HHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHH----HHHH-----H-HHHHHHHHHHHHH----- CSTF2_1 netsurfp ----------------EEEE--------HHHHHHHHHH----EEEEEEE----------EEEE---HHHHHHHHHHH--------EEEE------------------------------------HHHHHH-----HHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHH--HHHHHH--HHHHHHHHHHHHHHHHH---- CSTF2_1 soprano ----------------EEEEE-------HHHHHHHHHH---EEEEEEEE---------EEEEEE--HHHHHHHHHHH--------EEEEE--------HHHH-----------------------HHHHHHH----HHHHHHHHHHHHHHH---HHHHHHHHHH--HHHHHHHHHHHHH----HHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHH--HHHHH----HHHHHHHHHHHHHHH----- CSTF2_1 consensus MSGDGATEQAAEYVPEKVKKAEKKLEENPYDLDAWSILIREAQNQPIDKARKTYERLVAQFPSSGRFWKLYIEAEVTILFYFFLYQYCSIHCSDRKQVRNIAN CSTF3_2 sequence ------HHHHH--HHHHHHHHHHHHHH----HHHHHHHHHHHH---HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHH- CSTF3_2 psipred ---------------HHHHHHHHHHHH----HHHHHHHHHHHH---HHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHH-- CSTF3_2 prof ---------------HHHHHHHHHHH-----HHHHHHHHHHH-----HHHHHHHHHHHHH----HHHHHHHHHHHH----HHHHHHHHHHH------------ CSTF3_2 jnet --------------HHHHHHHHHHHHH----HHHHHHHHHHHH---HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHH-- CSTF3_2 sable --------------HHHHHHHHHHHHH----HHHHHHHHHHHHH--HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHH-- CSTF3_2 proteus ---HHHHHHHHHH-HHHHHHHHHHH------HHHHHHHHHHHH---HHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHEEEEEEEEEE----HHHHHHH-- CSTF3_2 sspro4 --------------HHHHHHHHHHHHH----HHHHHHHHHHHHH--HHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHH- CSTF3_2 psspred ------HHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHH--HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHH--HHHHHHHH- CSTF3_2 spineX -------HHHHH--HHHHHHHHHHHHH----HHHHHHHHHHHH---HHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHH-------EEEEE-- CSTF3_2 raptorxss -------HHH-----HHHHHHHHHHHH----HHHHHHHHHHHHH--HHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHH-- CSTF3_2 SPARROW -------HHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHH---HHHHHHHHHHHHHH----HHHHHHHHHHHHHH--HHHHHHHHHHH---HHHHHHH-- CSTF3_2 *SPARROW -------HHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHH----HHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHEEH CSTF3_2 HMMSTR -----HHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHH---HHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHH-- CSTF3_2 porter ------HHHHHH--HHHHHHHHHHHHH----HHHHHHHHHHHH---HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHEEEEE---HHHHHH--- CSTF3_2 spine -----HHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHH---HHHHHHHHHHHHHHH----HHHHHHHHH--EEEEEHHHHH--------HHHHHHHHH CSTF3_2 nnssp -----HHHHHHHH-HHHHHHHHHHHHH----HHHHHHHHHHH----HHHHHHHHHHHHHH------EEEEEE----EEEEEEEE----------HHHHHHH-- CSTF3_2 pssfinder ------HHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHH---HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHH CSTF3_2 sspal -------HHHHHHHHHHHHHHHHH-------HHHHHHHHHHHH---HHHHHHHHHHHHHH------EEEEEEE--EEEEEEEEEE-EEEEEEE-HHHHHHHHH CSTF3_2 ssp ------HHHHHHHH-HHHH-HHHHH------HHHHHHHHHHHH----HHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHEEEEEE--HHHHH---- CSTF3_2 sspred ---------------HHHHHHHHHHHH----HHHHHHHHHHHHH---HHHHHHHHHHHHH----HHHHHHHHHHHHH---HHHHHHHHH-----HHHHHHH-- CSTF3_2 netsurfp -------HHHH-----HHHHHHHHHHH----HHHHHHHHHHHH---HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHH-HHHHHHH-- CSTF3_2 soprano -------HHHHH--HHHHHHHHHHHHH----HHHHHHHHHHHH---HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHH-- CSTF3_2 consensus MSEQTPAEAGAAGAREDACRDYQSSLEDLTFNSKPHINMLTILAEENLPFAKEIVSLIEAQTAKAPSSEKLPVMYLMDSIVKNVGREYLTAFTKNLVATFICVFEKVDENTRKSLFKLRSTWDEIFPLKKLYALDVRVNSLDPAWPIKPLPPNVNTSSIHVNPKFLNKSPEEPSTPGTVVSSPSISTPPIVPDIQKNLTQEQLIRQQLLAKQKQLLELQQKKLELELEQAKAQLAVSLSVQQETSNLGPGSAPSKLHVSQIPPMAVKAPHQVPVQSEKSRPGPSLQIQDLKGTNRDPRLNRISQHSHGKDQSHRKEFLMNTLNQSDTKTSKTIPSEKLNSSKQEKSKSGEKITKKELDQLDSKSKSKSKSPSPLKNKLSHTKDLKNQESESMRLSDMNKRDPRLKKHLQDKTDGKDDDVKEKRKTAEKKDKDEHMKSSEHRLAGSRNKIINGIVQKQDTITEESEKQGTKPGRSSTRKRSRSRSPKSRSPIIHSPKRRDRRSPKRRQRSMSPTSTPKAGKIRQSGAKQSHMEEFTPPSREDRNAKRSTKQDIRDPRRMKKTEEERPQETTNQHSTKSGTEPKENVENWQSSKSAKRWKSGWEENKSLQQVDEHSKPPHLRHRESWSSTKGILSPRAPKQQQHRLSVDANLQIPKELTLASKRELLQKTSERLASGEITQDDFLVVVHQIRQLFQYQEGVREEQRSPFNDRFPLKRPRYEDSDKPFVDSPASRFAGLDTNQRLTALAEDRPLFDGPSRPSVARDGPTKMIFEGPNKLSPRIDGPPTPASLRFDGSPGQMGGGGPLRFEGPQGQLGGGCPLRFEGPPGPVGTPLRFEGPIGQAGGGGFRFEGSPGLRFEGSPGGLRFEGPGGQPVGGLRFEGHRGQPVGGLRFEGPHGQPVGGLRFDNPRGQPVGGLRFEGGHGPSGAAIRFDGPHGQPGGGIRFEGPLLQQGVGMRFEGPHGQSVAGLRFEGQHNQLGGNLRFEGPHGQPGVGIRFEGPLVQQGGGMRFEGPSVPGGGLRIEGPL GQGGPRFEGCHALRFDGQPGQPSLLPRFDGLHGQPGPRFERTPGQPGPQRFDGPPGQQVQPRFDGVPQRFDGPQHQQASRFDIPLGLQGTRFDNHPSQRLESVSFNQTGPYNDPPGNAFNAPSQGLQFQRHEQIFDSPQGPNFNGPHGPGNQSFSNPLNRASGHYFDEKNLQSSQFGNFGNIPAPMTVGNIQASQQVLSGVAQPVAFGQGQQFLPVHPQNPGFVQNPSGALPKAYPDNHLSQVDVNELFSKLLKTGILKLSQTDSATTQVSEVTAQPPPEEEEDQNEDQDVPDLTNFTVEELKQRYDSVINRLYTGIQCYSCGMRFTTSQTDVYADHLDWHYRQNRTEKDVSRKVTHRRWYYSLTDWIEFEEIADLEERAKSQFFEKVHEEVVLKTQEAAKEKEFQSVPAGPAGAVESCEICQEQFEQYWDEEEEEWHLKNAIRVDGKIYHPSCYEDYQNTSSFDCTPSPSKTPVENPLNIMLNIVKNELQEPCDSPKVKEERIDTPPACTEESIATPSEIKTENDTVESV PCF11_1 sequence --------------HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------HHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHH-----HHHHHHHH--------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------------------------------------------------------------------------HHHHH-----------------------HHH---------HHHHH-----------------------------HHHH--------------------------HHHHHH-------------------------------------HHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PCF11_1 psipred --------------HHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------EEEEEHHHHH----HHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PCF11_1 prof --------------HHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHHHHHHHH---------EEEEEEHHHH-----HHHHHHHHHHHHHHHHH-----------EEE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PCF11_1 jnet --------------HHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------EEEEEEHHHHH----HHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHH-----HHHHHHHHH-------------------------HH----------------------------HHH--HHHH-HHHHHHHHHHHHH----HHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PCF11_1 sable --------------HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHEHHHHHHHHHH-HHHHHHHHH-HHHHHHHHHH---HHHHHHHHHHHHHHH-------HHHHHHH--------------------------HHHHHHHHH---------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----------------------------------------------HHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PCF11_1 proteus ------HHH-----HHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------HHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHH----HHH--HHHHHH-------------------EEEE-HHHH-----------------------------H---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHH-------HHHHHH---H----------------------EEEEEEE------HHHHH-------------------------------H----------------------E----------HH-----HHHH-------------------HH---------------------HHHH------------------------------------------------------EEE--------HHHHHH-HHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHH-HHHHH--------------------------HHH----------HHHHH-------------------EEEE------------------EEE-----------------------------------------EE-------------E-------E------EEEE---------EEE------------------------------------------------EEEE--------------------------------EEEEEEE--------------------- PCF11_1 sspro4 --------------HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------EEEEEEEE--------HHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PCF11_1 psspred -----H--------HHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHH--HHHHHHHHHHHHH-------------------------------------------------------H---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------------------------------------------------------------------------HHHHH----------------------HHHHHHHHHHHHHHHHHHHHHHHH---------------------HHHHHHHHHHHH---HHHHHHHHH-------HHHHHHHHHHHHHHHHHHHHHHHHHHH-H--------------HHHHHHH-------HHH-H----------------HHHH---HHH------------HHHHHHH-HHHHHHHH---H-HHHHHHHHHHHHHHHHHHHH---HHH-HHHHHHH--------HHHHHHHHHHHHHHHHHH--HHHH--HHH--------------------------------------------HHH-HHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PCF11_1 spineX -----HHHH-----HHHHHHHHHHHH---------HHHHHHHHHHH-HHHHHHHHHHHHHHH-----------------------------HHHHHHHHHHHHHH---------HHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PCF11_1 raptorxss --------------HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHH--HHHHH--HHHH--------------------------H-----------------------------------HHH--HHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HH-----------------------HHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ PCF11_1 SPARROW --------------HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHH-H--------HHHHHHHHH-----HHHHHHHHHHHHHHHHHHHH------HHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PCF11_1 *SPARROW --HHHHHH------HHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------HEEHHHHHHH----EHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHH---HHHHHHHHHHHH-------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PCF11_1 HMMSTR -----HHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHH-HHHHHHHHHHHHHHHHH------HHHHHHHHHHHHH----HHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHH-------EEEEEEE--------------------E----HH----------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----------------------------------------------------------------HHHHH-----------HHH-------------------------------------HHHHHHHH---------------------------------------------------------------------------------------------------HH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHH------------HHHHHHHHHHHHHHHHHHHHHHHH---------------------------HHHH----------HH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PCF11_1 porter -----HHHHH---HHHHHHHHHHHHHHH------HHHHHHHHHHHH-HHHHHHHHHHHHHHH----------HHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHH----HHHHHHHHHH-----------------------------------------------------HHHH-----HHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHH-------------------------------------------------------------------------------HHHH-----------------HHH----------------------HHHH--------------------------------------HHHH--------------HHHH---------HHH--------------------------HHH----------------------------------------HHH-------------------------------HHH-------------HHHH-------------------------------------------------------------------------------------------------------HHHHH------------HHHH-HHHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PCF11_1 spine --------------HHHHHHHHHHHHH-----------EEE--------HHHHHHHHHHHH-----------EEEHHHHHHHH--HHHHHHHHHHHHHEEEEEE-------HHHHHHHHH----------------EE----------------------------------------EE-------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEE--------------------------------------------EEEE--------------------------HHHHHH-----------------------------HHHHHHHHHHHH-----------------------------------------HHHHHHH---------HHHHHHHHHHH-------------------------------------------------------------EE---------------------------------------------------------------HHHHHHHH------------------------------HHHHH--------------------------------------------EE----------HHHHH-HHHHHHHHHHHHH---------EEEHHHHHHHHHHH-------------------------------------------HHHHHHH---------------------EEE------------------EE-------------------------------------------------------------------------EE------------------------EE-----------------------------------EEE-----------EE-------------------------------------EE--------- PCF11_1 nnssp -----HHHHHHHHHHHHHHHHHHHHHHH-------EEEEEEEEE------HHHHHHHHHHHHHH--------HHHHHHHHHHHH-HHHHHHHHH--EEEEEEEEE---HHHHHHHHHHHHHHHHHHHHHHH--------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------------------------------------EEEEEE---------------------HHHHHHHHHHHH------------HHHHHHHHHHHHH------HHHHHHHHHH--------------------------HHHHHHHHHHH-HHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHH----EEEEEEEE------HHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHH------------------------HHHHH----HHHHHHHHHH-------------------EEEE--------------------------------------------------------------------------------------------EEEE----------------------EEEE---------------------EEEEE--------EEEEE--------EEEEEEEEEEEEEEEEEE-----EEEEEEE----------EEEE------- PCF11_1 pssfinder ----------------HHHHHHHHHHH------------HHHHHH--HHHHHHHHHHHHHH-----------EEEEEEEHHHHH----EEHHH------EEEEEE-----HHHHHHHHHH------------EEE------------------------EE----------------EEEE----------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----------------EE---------EEEEEE-------EEEEE-----------HHH---------HHHHHHHH----------------------------------HHHHHH---------------------------HHHHHHH--------HHHHHHH----------HHHH----------HHHHHHHHH-----------EEE-------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH-------EEEEE------------------EE-EEHHHEE-------HHHHHHHHHHHHHH---------EEEEEEHHHHHHHHH--HHH---------------EEE------------EE------HHHHHH---------------------EEEE-----------------EEEE-----------------------------------------EE------------------EEEEE----EEEE-----------------------EEE----------EEE----------EEEE--------EEEE---------EEEE----------EE--------EE-EEE---------EEEE-------- PCF11_1 sspal ------HHHHHHHHHH------------EEEE----HHHHHHHHH---HHHHHHHHHHHHH-----------EEEEEHHHHHH--HHHHHHHHHHEEEEEEEEEHHHHHHHHHHHHHHH----HHHHHHHHH---EEEE-----------------EEEEE----------------EEEE--EEEE-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHEEEEEEEE--------------EEEE--------------------------------------HHHHHHHHH----HHHHHHHHHH-----------------------------HHHHHHHHHHH----------------------------------HHHHHHHHHHHHHHHH--------HHHHHHHHHH---HHHHHHHHHHHH--HHHHHHHHHHHH--------------------------------------------------------------------HHHHHHHHH---HHHHHHHHH---------HHHHHHHHHH------------------------------------HHHHHHHHH---------------------------------EEEE--------HHHHHHHHHHH------------HHHHHHHHHHHHHHHH-----------------------------------------HHHHHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PCF11_1 ssp ---------------HHH-HHHHHHH-------------HHH-HH-------HHHHHHHHHHH------------------------HHHH-------HHHHH----------HHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PCF11_1 sspred --------------HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------HHHHHHHH------HHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PCF11_1 netsurfp ---------------HHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHH-H--------HHHHHHHHHHH------------------------------------------------------------HHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHH--H---------------------------------------------------------------------------------------------------------------H----H------HH------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHH------H----HH--H-------------------HHH---------------------------------------------------------------------------HH---------HHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ PCF11_1 soprano --------------HHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------HHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHH------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H----H--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PCF11_1 consensus SGTQLATYSFEVCDSILNIGPCANAAVGEPAFLSEEFQNSPEPDLEIVVCSGHGKNGALSVLQKSIRPQVVTTFELPGCYDMWTVIAPVRKEEEDNPKGEGTEQEPSTTPEADDDGRRHGFLILSREDSTMILQTGQEIMELDTSGFATQGPTVFAGNIGDNRYIVQVSPLGIRLLEGVNQLHFIPVDLGAPIVQCAVADPYVVIMSAEGHVTMFLLKSDSYGGRHHRLALHKPPLHHQSKVITLCLYRDLSGMFTTESRLGGARDELGGRSGPEAEGLGSETSPTVDDEEEMLYGDSGSLFSPSKEEARRSSQPPADRDPAPFRAEPTHWCLLVRENGTMEIYQLPDWRLVFLVKNFPVGQRVLVDSSFGQPTTQGEARREEATRQGELPLVKEVLLVALGSRQSRPYLLVHVDQELLIYEAFPHDSQLGQGNLKVRFKKVPHNINFREKKPKPSKKKAEGGGAEEGAGARGRVARFRYFEDIYGYSGVFICGPSPHWLLVTGRGALRLHPMAIDGPVDSFAPFHNVNCPRGFLYFNRQGELRISVLPAYLSYDAPWPVRKIPLRCTAHYVAYHVESKVYAVATSTNTPCARIPRMTGEEKEFETIERDERYIHPQQEAFSIQLISPVSWEAIPNARIELQEWEHVTCMKTVSLRSEETVSGLKGYVAAGTCLMQGEEVTCRGRILIMDVIEVVPEPGQPLTKNKFKVLYEKEQKGPVTALCHCNGHLVSAIGQKIFLWSLRASELTGMAFIDTQLYIHQMISVKNFILAADVMKSISLLRYQEESKTLSLVSRDAKPLEVYSVDFMVDNAQLGFLVSDRDRNLMVYMYLPEAKESFGGMRLLRRADFHVGAHVNTFWRTPCRGATEGLSKKSVVWENKHITWFATLDGGIGLLLPMQEKTYRRLLMLQNALTTMLPHHAGLNPRAFRMLHVDRRTLQNAVRNVLDGELLNRYLYLSTMERSELAKKIGTTPDIILDDLLETDRVTAHF CPSF1_1C sequence -----EEEEEEEEEEEE------EEEE------------------EEEEEEE-----EEEEEE-----EEEEEEE-----EEEEEE----------------------------------EEEEEEE--EEEEE---EEEEEE----------EEEEEE----EEEEEE--EEEEEE----EEEEE------EEEEEE---EEEEEEE--EEEEEEEEE------EEEEE-----------EEEEEEEEE----EEEEE----------------------------------------------------------------------EEEEEEE---EEEEEE----EEEEEE--------EE-------------HHHHHHH-------EEEEEEEE--------EEEEEE---EEEEEEEE----------EEEEEEE-------------------------------EEEEEEEEEE----EEEEE-----EEEEEE---EEEEEE------EEEEEE---------EEEEEE--EEEEEE------------EEEEE------EEEEE----EEEEEEEE-------------------------------EEEEEEEEE----EEE--EEEE----EEEEEEEEEEEE----------EEEEEEEEE---------EEEEEEEEEEEE----------EEEEEEEEE----EEE------EEEEE--EEEEEE-----EEEEEEEE--EEEEEEEEE--EEEEEE----EEEEEEE----EEEEEE------EEEEEEEEE---EEEEEEEE----EEEEEE-----------EEEEEEEEE---EEEEEEEE------------------EEEEEEEE----EEEEEE--HHHHHHHHHHHHHHHH-----------------------------EEEHHHHHHHH---HHHHHHHHHHH---HHHHHHHHHHHHHH---- CPSF1_1C psipred ------EEEEEEE-------------------------------EEEEEEE-----HHHHHHH-----EEEEEEE------EEEEEE--------------------------------EEEEEEE---EEEEEE--EEEEE----------EEEEEE----EEEEEEE----EEEE----EEEEE-----EEEEEEE---EEEEEE---EEEEEEE------------------------EEEEEEEE--------------------------------------------------------------------------------EEEEEEE---EEEEEE------EEEE------------------------------------HHHHHHHHH--------EEEEEE---EEEEEEE----------EEEEEEE-----------------------------------EEEEEE-----EEEEEE-----EEEEE----EEEEE------EEEE-----------EEEEE---EEEEEEE-----------EEEEE------EEEEE----EEEEEE-----------------------------------EEEEEE-----EE-----EE-----EEEEEEEEEEEE--------EEEEEEEEE----------EEEEEEEEEEE----------EEEEEE-------HHHHHHH--EEEEE---EEEEEE--------EEEE---EEEEEEEE---EEEEE-----EEEEEEE----EEEEEEE-----EEEEEEEEE---EEEEEEE-----EEEEEE-----------EEEEE----------EEEEEE------------------EEEEEEE----EEEEE---HHHHHHHHHHHHHHHH------------EEEEE---------------HHHHHHHHH---HHHHHHHHHH---HHHHHHHHHHHHHHH--- CPSF1_1C prof -------EEEEEEEEE--------EEEE----------------EEEEEEE------EEEEEE----EEEEEEE-------EEEEE----------------------------------EEEEEE---EEEEEE----EEE----------EEEEEE-----EEEEE----EEEE----EEEEEE------EEEEEE---EEEEEE----EEEEEEE------EEEEEE-----------EEEEEEE-----EEEE------------------------------------------------------------------------EEEEEEE---EEEEEE-----EEEEE-------------------------------------HHHEEEE--------EEEEEEE---EEEEEEEE----------EEEEEE-----------------------------------EEEEE------EEEEEE---EEEEEEE----EEEEE------EEE-----------EEEEEE----EEEEEE-----------EEEEE------EEEEE----EEEEEEE----------------------------------EEEEEEE-----------E-----HHHHHEEEEEEEE--------EEEEEEEE------------EEEEEEEEE-----------EEEEEEE------HHHHH----EEEEE---EEEEEE-----EEEEEE----EEEEEEEE----EEEHHHHH-EEEEEE-----EEEEEE-------EEEEEEE-----EEEEEE----EEEEEE--------------EE---------EEEEEEEE------------------EEEEEEE---EEEEEEE----HHHHHHHHHHHHHH------------------------------E-HHHHHHHH---HHHHHHHHHH----HHHHHHHHHHHHH----- CPSF1_1C jnet -------EEEEEEEE-------HEEEE------------------EEEEEE------EEEEE-----EEEEEEEE-----EEEEEE---------------------------------EEEEEEE----EEEE-----EE-----------EEEEEE-----EEEEE----EEEEE----EEEE-------EEEEEE---EEEEEE----EEEEEE-----------E------------EEEEEEE----------------------------------------------------------------------------------EEEEEE----EEEEE------EEEE-------------------------------------HHHHEEE---------EEEEEE---EEEEE-------------EEEEEE------------------------------------EEE--------EEEE-----EEEEEE----EEEEE------EEEEEE---------EEEEE---EEEEEEE----------EEEEE-------EEEE-----EEEEEEE-----------------HHH---------------EEEEEE-----EE---EEE-----EEEEEEEEEEE---------EEEEEEEEE-----------EEEEEEEEE-----------EEEEEEEEE----EEEEEE----EEEEE--EEEEEEE-----EEEEEE---EEEEEEEE---EEEEEEE---EEEEEE------EEEEE------EEEEEEEE-----EEEEEEE----EEEEEE-----------EEEEEEEEE------EEEE---------------------EEEEEE----EEEEE---HHHHHHHHHHHHHHHHH--------HHHH----------------EE-HHHHHHHH---HHHHHHHHHH----HHHHHHHHHHHHHHHHHH CPSF1_1C sable ------EEEEEEEEEE------EEEEEEE---------------EEEEEEEE-----EEEEEE----EEEEEEEE-----EEEEEE---------------------------------EEEEEE----EEEEEE----EE----------EEEEEEE-----EEEEE---EEEEEE---EEEEEE-----EEEEEE----EEEEEE----EEEEEEE----------HHH---------EEEEEEEEE----EEEE------------------------------------------------------------------------EEEEEE----EEEEEE-----EEEEE--------EE--------------------------------EEE-------EEEEEEE---EEEEEEEE---------EEEEEEEE---------------------------------EEEEEEE-----EEEEE-----EEEEEE---EEEEEEE-----EEEEEE--------EEEEEE----EEEEEE----------EEEEEE----EEEEEE-----EEEEEEE----------------------------------EEEEEE-----EEEEEEEE------EEEEEEEEEE----------EEEEEEEE-----------EEEEEEEEEEE----------EEEEEEEE--------EE----EEEEE---EEEEEEE----EEEEEE----EEEEEEEE---EEEEEE----EEEEEEE----EEEEEE------EEEEEEEEE---EEEEEEEE----EEEEEE-----------EEEEEEEEE-----EEEEEEE------------------EEEEEEE----EEEEEE---HHHHHHHHHHHHHHHH----------------------------EEE--HHHHHHH--HHHHHHHHHHH---HHHHHHHHHHHHHHHH-- CPSF1_1C proteus ---H-----HHHHHHH-------H-E---EEE------------EEEEEE--------HHEEE-----EEEEEEE------EEEEE---------------------------------EEEEEEE---EEEEE---EEEEEE---------EEEEEE-----EEEEE----EEEEE---EEEEE------EEEEEEE---EEEEEEE--EEEEEEEEE-------EEEE-----------EEEEEEE------------------H--------HHH-----------HHHHH-----------HHHH-------------------EEEEEEEE---EEEEEE----EEEEEE------------------------HHHH---------EEEEEEE---------EEEEEE--EEEEEEEE-----------EEEE----HHHHHHH------------------------EEEEEEE-------EEEEE----EEEEEE----EEEEE----EEEEE------------EEEEE---EEEEEEE-HHHH------EEEEE------EEEEE----EEEEEEE----------------HHHH-----H-----H---EEEEE-----EE----EEE-----EEEEEEEEE-----------EEEEEEEEEE---------EEEEEEEEEE-----------EEEEEEEE------EEEE----EEEEEE--EEEEEE------EE-------EEEEEEEE---EEEEEE---EEEEEEE------EEEEE------EEEEEEEE-----EEEEEE-----EEEEEE------------EEEEEEEE----EEEEEE--------------------EEEEEEEE--EEEEEEE--HHHHHHHHHHHHHHHHH--------HHHHHH-----------------HHHHHHHH---HHHHHHHHHH----HHHHHHHHHHHHHHHH-- CPSF1_1C sspro4 -------EEEEEEEEE------EEEEEE-----------------EEEEEE------EEEEEE-----EEEEEEE-----EEEEEE---------------------------------EEEEEEE---EEEEEE----EEE----------EEEEEEE----EEEEEE--EEEEEE----EEEEE------EEEEEE---EEEEEE---EEEEEEEE-------EEEEEE----------EEEEEEEE----EEEEE-----------------------------------------------------------------------EEEEEEE---EEEEEEE---EEEEEE-------EEE---------------------------EEEEEEEE-------EEEEEEE--EEEEEEEEE----------EEEEEEE---EE-----------------------------EEEEE-------EEEEE----EEEEEE----EEEEE------EEEEE----------EEEEE---EEEEEEE-----------EEEEE------EEEEE----EEEEEEE---------------------------------EEEEEEE-----EEEE-EEEE-----EEEEEEEEEE----------EEEEEEEEE----------EEEEEEEEEEE----------EEEEEEEEE----EEEEEEE--EEEEEE--EEEEEE----EEEEEEEE---EEEEEEEEE--EEEEEE----EEEEEEE----EEEEEEE-----EEEEEEEEE---EEEEEEEE----EEEEEE-----------EEEEEEEEE-----EEEEEEE------------------EEEEEEE----EEEEEE--HHHHHHHHHHHHHHHHH--------HHHH----------------EEEHHHHHHHHH--HHHHHHHHHHH---HHHHHHHHHHHHHHHH-- CPSF1_1C psspred -------EEEEE-EEE--------EEE-------H---------EEEEEEE------EEEEEE----EEEEEEEE-----EEEEEEE-------------------------------EEEEEEEE---EEEEEE----EE-----------EEEEEEE---EEEEEEE---EEEEE---EEEEE------EE-EEEE---EEEEEEE--EEEEEEEE------EEEEEEEE---------EEEEEEEEE-------HH------HH-----------------------HHHHH----------HHHHH------------------EEEEEEEE---EEEEEE----EEEEEE---------------------HHHHHHHHHH------E-EEEEEEE-----EEEEEEEE--EEEEEEEE----------EEEEEEEE---------------------------------EEEEEEE----EEEEEEE----EEEEEE----EEEEE------E-EEE----------EEEEE---EEEEEEE----E------EEEEE------EEEEE----EEEEEEE-------------HHHHHHHHHH-H--------EEEEEEE-----EE---EEEE----EEE-EEEEEEE---------E-EEEEEEEEE---------EEEEEEEEEE-----------EEEE-EEEE------EEEE---EEEEEE--EEEEEEE----E-EEEEE---EEEEEEEE---EEEEEE----EEEEEEE----EEEEEE------EEEEEEEE----EEEEEEEE---EEEEEEE----------E-EEEEEEE----EEEEEEEE-------------------EEEEEEE---EEEEEEE--HHHHHHHHHHHHHHHHH--------HHHHHHH-------------EE-HHHHHHHHH--HHHHHHHHHHH---HHHHHHHHHHHHHHHHH- CPSF1_1C spineX -------EEEEEEEEEE-----EEEEE------------------EEEEEE------EEEEEE-----EEEEEE-------EEEEEE----------EEEEEEEEEEE-----------EEEEEEE----EEEEE---EEEE----------EEEEEEE----EEEEE----EEEEEE--EEEEEE-----EEEEEEE---EEEEEE----EEEEEEEE----EEEEEEEEE-------EEEEEEEEEE--EEEEEEEEEEEEEEEEEEEEE--EEEEEEE----EEE-EEEEEEEE---EEEEE----EE----------EEEE----EEEEEEE---EEEEEE-----EEEEEEE----EEEEEEEE--------EEEEEEEEEEE---EEEEEEEEE------EEEEEEE----EEEEEEE--------EEEEEEEEEEEEEEEEEE---EEEEEEE---EEEEEEEEE-EEEEEEEEE-----EEEEEE----EEEEEE----EEEEE--------EEE----------EEEEE---EEEEEEE-----------EEEEE------EEEEE----EEEEEEEE-----------------EEEE----------EEEEEEEEE-----E---EEEEE---EEEEEEEEEEEE--------EEEEEEEEEEE---------EEEEEEEEEEE----------EEEEEEEEE----EEEEEE---EEEEEE--EEEEEEE---EEEEEEEEE--EEEEEEEEE--EEEEEEEE--EEEEEEE----EEEEE--------EEEEEEEE----EEEEEE-----EEEEEE-----------EEEEEEEEE-----EEEEEEE------------EEE---EEEEEEE----EEEEE---HHHHHHHHHHHHHHHH---------HHHH----------------EE-HHHHHHHH---HHHHHHHHHH----HHHHHHHHHHHHH----- CPSF1_1C raptorxss -------EEEEEEEEEE----EEEEEEEE-----HHH--------EEEEEE-------EEEEE----HEEEEEE-------EEEEEE-------------------------------EEEEEEEE---EEEEEE----E-E----------EEEEEEE---EEEEEE---EEEEEE----EEEEE-------EEEEEE--EEEEEE---EEEEEEEE-------HH--------------EEEEEEEE-----EE-HH------HHH----------------------------------------------------HH------EEEEEEEE---EEEEEE-------EEE--------EE----------HHH--------------HHEEEEEE--------EEEEEE--EEEEEEEE-----------EEEEEE--------------HHH-H----------------EEEE-EE-----EEEE-----EEEEEE----EEEE---------EE-----------EEEEE---EEEEEEE---------EEEEEE-------EEEEE----EEEEEEEE-----------HHHH--------------EEEE-EEEEEE----EEEEEEEE-------EEEEEEEEEE---------EEEEEEEEE-----------EEE-EEEEEE----------EEEEEEEEE-----EEHH----EEEEEE--EEEEEE-----EEEEEEEE--EEEEEEEEE--EEEEEEEE--EEEEEEE----EEEEEE------EEEEEEEEE---EEEEEEE-----EEEEEE-------H-----EEE-EEE----E-EEEE--E-----------------EEEEEEEE---EEEEEE--HHHHHHHHHHHHHHH----------HHH------------------E-HHHHHHH----HHHHHHHHHH----HHHHHHHHHHHHHHHH-- CPSF1_1C SPARROW -------EEEEEEEEEE-EH-H---EEE-----------------EEEEEE------EEEEEE----EEEEEEEE-----EEEEEE----------------------------------EEEEE----EEEEE------------------EEEEEEE----EEEEEE---EEEEE---EEEEEE-----EEEEE-----EEEEEE----EEEEEEE-------EEEEEE------------EEEEEE-----EEEE--------------------------EEE-----EEEE---------------------------------EEEEEEE---EEEEEE-----EEEEE--------E----------------------------HHHH------------EEEE-----EEEEEE-------------E---------------------------------------EEEEEE------EEEEE----EEEEE-----EEEE-------EEEEE-E--------EEEEE---EEEEEE------------EEEEE----EEEEEEE----EEEEEEE---------------------------------EEEEEEEE----EEEE-EEEEE----EEEEEEEEEE----------EEEEEEEEE-----------EEEEEEEEEE----------EEEEEEEEEE---EEEEEE---EEEEEE--EEEEEE-----EEEEEEE----EEEEEEEE--EEEEEE----EEEEEEE----EEEEEE-------EEEEEEEE----EEEEEE-----EEEEE------------EEEEE----------EEEE---------------------EEEEE-----EEEEE---HHHHHHHHHHHHHHHH---------HHH------------------E-HHHHHHH----HHHHHHHHHHH---HHHHHHHHHHHHHHHH-- CPSF1_1C *SPARROW ------EEEEEEHHHHHH------EEEE------HH---------EEEEEE-------HEEHHH---HHEEEE-------EEEEEEE--------------------------------EEEEEE----EEEEEHHHHHHHHHH--------EEEEE-----EEEEEEE----EEEE----EEE-------EEEEEE----EEEEE-----EEEEEE---HHHHHHHHHHHHHHHH----EEEEEEEEE-----EE---------------------------------HHHHH-----------------------------------EEEEEE----EEEEEE----EEEEEEE-----HHHHHHH---------H--HHHH-----HHHHHHHHHHHH-------EEEEEEE--EEEEEEEE-------HHHHHEHHH--HHEEE-----------------HHHH--------EEEEE-E----EEEEE----EEEEE-----EEEE---E---EEEEE----------EEEEE---EEEEEE------E-----------E---EEEEEE----EEEEEE-----HHHHHHH-HHHHHHHH-------------EEEEEEE------EE-EEEEEE-HHHHHHHHHEEEEE---------EEEEEE-EEEE---EEEE--EEEEEEEEEE------HHHHHHHHHHHH-----EEEEEHE---EEEE---EEEEEE--HHHHHHHHHH-HHHHHHHHHHH--EEEEE----EEEEEEE------EEEEE------EEEEEEEEE---EEEEEEE-----EEEEE------------EEEEHH--------EEEEEEE------------------EEEEEEE----EEEEE---HHHHHHHHHHHHHHHHH--------HHHHHHE-------------EE-H-EHHHHHH--HHHHHHHHHHH---HHHHHHHHHHHHHHHHHH CPSF1_1C HMMSTR ---HHHEEEHHHHHHHH---------------------------EEEEEEE-------EEEEE-----EEEEEEE------EEEEEE-------------------------------EEEEEEEE---EEEEEE--EEEEEE----E----EEEEE-----EEEEEEE--EEEEEE---EEEEEE-----EEEEEEE---EEEEEE---EEEEEEEE-------EEEEEEE--------EEEEEEEEE----EEEEE--------------------------------HHHE-----------HHHHHH------------------EEEEEEE---EEEEEE----EEEEEEE------EEEEE----------HHHHHHHH-------HHHEEEHH--------EEEEEE---EEEEEEE----------EEEEEEE-----EE--------------------------EEEEEEEE-----EEEEEE----EEEEE-----EEEEEEE------EEEE--------EEEEEE---EEEEEEE-----------EEEEE----EEEEEEE----EEEEEEE------E----------HEE------------EEEEEEEEE----EEEEEEEEE-----EEEEEEEEEEEE--------EEEEEEEEE---------EEEEEEEEEEE-----------EEEEEEEEEE---EEEEEEE--EEEEEE--EEEEEEE----EEEEEEE-----EEEEEEE--EEEEEE--E-EEEEEEE----EEEEEEE----E-EEEEEEEE----EEEEEEE---EEEEEEE-----------EEEEEEEEE----EEEEEE--EE---------------EEEEEEEE----EEEEEE--HHHHHHHHHHHHHHHHH--------HHHHHHE-----------E-EEEHHHHHHHH---HHHHHHHHHH----HHHHHHHHHHHHHHHH-- CPSF1_1C porter --EEEEEEEEEHHHHH--------EEE------HHHH-------EEEEEEE------EEEEEE-----EEEEEEE-----EEEEEE---------------------------------EEEEEEE---EEEEE----EEEE----------EEEEEEE----EEEEE----EEEEE---EEEEEE-----EEEEEEE---EEEEEE---EEEEEEEE------EEHHHEE----------EEEEEEEEHHHHHH----------------------------------HHHHH-----------HHHHHH------------------EEEEEEE---EEEEEE----EEEEEE---------------------HHHHHHHHH-------EEEEEEEE-------EEEEEE----EEEEEEEE---------EEEEEEE----------------------------------EEEEEE------EEEEEE----EEEEEE----EEEEE------EEEEEE--------EEEEEE---EEEEEEE----------EEEEEE-----EEEEEE----EEEEEEEE------------HHH-HHH-------------EEEEEEE------E----EE---HHHHHHEEEEEEE----------EEEEEEEEEE---------EEEEEEEEE------------EEEEEEEEE----EEEEEEE--EEEEEE--EEEEEEE----EEEHHHE---EEEEEEEEE--EEEEEE----EEEEEEE----EEEEEE-------EEEEEEEE----EEEEEE-----EEEEEE----------EEEEEEEEE----EEEEEEEE---------------E---EEEEEEE---EEEEEEEE-HHHHHHHHHHHHHHHHH-H-H----HHHHHHHH--H-H-------E--HHHHHHHHH--HHHHHHHHHHH---HHHHHHHHHHHHHHH--- CPSF1_1C spine --HHHHHHHHHHH-------------------HHHHH--------EEEEE-------HHHHHHH-----EEEEE--------EEEE----------------------------------EEEE------EEE---HHHHHH----------EEEE-------EEEE-----HHHHH----------------EEE-----EEEEE-----EEEEEE-----------EE-----------EEEEEEE-----------------------------------------HHHHHH----------HHHHHH-------------------EEEEEE----EEEE------EEEEE-------EEEE-----------HHHHHHHHH---------EEEE---------EEEEE----HHHHH------------EEEEE-----------------------------------HHHHHHHHHH-----EEEE-----EEEE--------------------------------EEE------EEEE-----------------------EEEEE----EEEEE----------------HHHHHHHHH-------------EEEE-----------HHHHH-------EEEEEE-----------------EE-----EE---EEEEEEEEE------------HHHHHHH-------EEEE---------------HHHHHH-----------HHHHHHH-------HHHHHHHHHHHHHHH----EEEEEE------EEEEEEEEE-----EEEE------EEEEEE----------HHHHHH----------------------------EEE-----EEEEE------EEE-----HHHHHHHHHHHHHHH---------HHHHHHHH-HHHHHHHHHHHH--HHHHHHHHH-HHHHHHHHHHH-----HHHHHHHH----EEEE CPSF1_1C nnssp ---------HHHHHHHH-----------------HHHHH-----EEEEEEE-----------------EEEEEEE------------------------------------------EEEEEEEEHHHHHHHHHHHHHHHHH----------EEEEEEE--EEEEEEE-HHHHHHHH---EEEEEE------EEEEEE----EEEE-----EEEEEEE-----------------------EEEEEEEE----------------------------------------HHHHHH----------HHHHHH------------------EEEEEEE---EEEEEE----EEEEEEE------EEEEE--------HHHHHHHHHHHH--HHHHHHHHHHHH-------EEEEE--HHHHHHHH-----------EEEEEEE-----------------------HHHHHHHHHHHHH-HHHHHHH----EEEE-----EEEEE-HHHHHH-----------------------EEEE-----EEEEE-----------------EEEEEEEEEEEE--EEEEEE--------------HHHHHHHHHHHHHHH-------EEEEEEE---HHHHHHHHHHHHHHHHHHHHHHHHH------------------------------EEEEEEEEE---------HHHHHHHHHHH----EEEEEE--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----EEEEE------EEEEEEEEEEE---EEEEEE-----EEEEEEE---------EEEEEE----------------------------EEE----EEEEE-------------HHHHHHHHHHHHHHHHH--------HHHHHHH---HHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHH--EEEE- CPSF1_1C pssfinder ---HHHHHHHHHHHHHH---------------HHHHH--------EEEEE--------HHHHH------EEEEEE------EEEEEHHH-------------------------------EEEEE----EEHHH-HHHHHH-----------EEEE-------EEEEE---HHHHHH------EE-------EEEE-----EEEEEE----EEEEEEE----------EE-----------EEEEEEE----------------------------------------HHHHHHH----------HHHHH-------------------EEEEEEE---EEEEEE-----EEEEE-------EEEEE----------HHHHHHHHHH------HHHEEE---------EEEEEE---EEEEE-------------EEEEE-------EE------------------------EEE-EEEHHH------EEEE-----EEEEE----------EE----------EE------EEEE-----EEEEE----------------------EEEEEEE--EEEEEEE---------------HHHHHHHHHHHHHH-----EEEEEE-----HHHH-HHHHHHHHHH-EE---EEEEE---------EEEE--EEEE----EEEE--EEEE-EEEE---------HHHHHHHHHH-----EEEEE------------EEHHHHHHHHHHH---EE---HHHHH------HHHHH-HHHHHHHHHH------EEEEE-----EEEEEEE-------EEEEE------EEEEEE---------HHHHHHHH-----HHH------------------EEEEE--EEEEEEE----EEEE----HHHHHHHHHHHHHHH----------HHHHHHHH--HHHHHHHHHHHH---HHHHHHH--HHHHHHHHHH-----HHHHHHHHHH-HHHHH- CPSF1_1C sspal ------EEEEEEE-----------------HHHHHHHHH-----EEEEEEE------HHHHHHHHHH--EEEEEEE----HHHHHHHHHHHHHH--------------------------EEEE--------HHHHHHHHHH----------EEEE------EEEEEEE---HHHHHHHHHHEEEEE-----EEEEEEE--EEEE------EEEEEEE-----------------------EEEEEEE-----EEEE------HHHHH---------------------HHHHH----------------------------------EEEEEEE--------------EEEEEEE-------EEEE----------HHHHHHHHHH----HHHHHHHHHH-------EEEEEEE-------------------EEEEEEEE--------------------------------EEEEEEE----EEEEEEEE----EEEEEEE--------EEEE---------------EEEEEEE---EEEEEEE-----------EEEEEEEE---EEEEEEE--EEEEEEE---------HHHHHHHHHHHHHH-----------EEEEEEE---HHHHHHHHHHHHH---EEEEEEEE-----------------EEEE---EEEE---EEEEEEEEEEE--------HHHHHHHHHHH---EEEEEEE---HHHHHHHHH-HHHHHHHHH-------EEEEE-----HHHHHHHHHHHH-----------EEEEEEE-------EEEEEEEE------EEEE-----EEEEEEE---------HHHHHHHHEEEE---------------------EEEE----EEEEEEE---EEEEE-HHHHHHHHHHHHHHHH-----------HHHHHHHHH--HHHHHHHHHHHH-HHHHHHHHH---HHHHHHHHH----HHHHHHHHH-------- CPSF1_1C ssp -------EE-H-HEH-----------EE------------------EEEE----------EE-------EEEEE------EEEEEE---------------------------------EEEEEEE---EE-EEE---EH------------EEEEE-----EEEEEE----EEEEE----EEEEE-----EEE-EEE--HEEEEEEE--EEEEEEEE-------EE---------------EEEEEE--HHHHHHE--------------------------------------------------HH--------------------EEEEEE-----EEEEE-----EEE----------------------------------------HHHEEE---------EEEEEE---EEEEEE----------------EE------------------------------------EE---------EEEEE----------------EE--HH-----EE----------EEEEEE---EEEEEEE--------------EE-------EEE-------E--------------------------------------EEEEE------------EEE---------EEEEEEE--------EEEEEEE--------------EE---EE------------------EEE--------------EEEEE---EEEEE---------EH---------EEEE---EEEEEEHHHEEEEEEEE-----EEEEE-------EEEEEEEE----EEEEEE----EEEEEEE------------EE--------------------------------------EEEEE---HEEEEE----HHHHHHHHHHHHHHHH-------------------------------HHHHHHHH---HHHHHHHHHHH---HHHHHHHHHHHH-HH--- CPSF1_1C sspred ------EEEEEEEEE------------------------------EEEEEE------EEEEEE-----EEEEEE------EEEEEE---------------------------------EEEEEE-----EEEEE-----------------EEEEEEE----EEEEEE---EEEE-----EEEE-------EEEEE----EEEEEE----EEEEEEE------EEEEEEE-----------EEEEEE-----EEEEE-----------------------------------EEE-----EE--------------------------EEEEEEE---EEEEEEE----EEEEE--------EEE----------------HH----------EEE-----------EEEEE----EEEEEEE------------EEEEE-----------------------------------EEEEE-------EEEE-----EEEEEE----EEEE-------EEEEE----------EEEEE----EEEEEE-----------EEEEE------EEEE-----EEEEEEEE------HHHH--HH---H--------------EEEEEEEE-----E---EEEE-----EEEEEEEEEE----------EEEEEEEE------------EEEEEEEEEE----------EEEEEEEE-----EEEE------EEEEE--EEEEEE-----EEEEEE----EEEEEEEE---EEEEEE----EEEEEEE----EEEEEEE------EEEEEEE-----EEEEEE-----EEEEEE-----------EEEEEEEEE-------EEEEE-------------------EEEEEE---EEEEEE---HHHHHHHHHHHHHHHHH-----------------------------E-HHHHHHHH---HHHHHHHHHHH---HHHHHHHHHHHHHHHH-- CPSF1_1C netsurfp --------EEEEEEEE-----EEEEEEEE----------------EEEEEE------EEEEEE-----EEEEEEE------EEEEE----------------------------------EEEEEE----EEEEE-----------------EEEEEE-----EEEEEE---EEEEE---EEEEEE-----EEEEEEE---EEEEEEE--EEEEEEEE------EEEEEEEE---------EEEEEEEE--------------------------------------------------------------------------------EEEEEEE---EEEEEE------EEEE---------------------------------------EEEEEEE------EEEEEEE---EEEEEE------------EEEEEEE----------------------------------EEEEE-------EEEE-----EEEEEE----EEEEEE-----EEEEE----------EEEEE---EEEEEEE-----------EEEEE------EEEE-----EEEEEEE-----------------------------------EEEEE------EE---EEE-----EEEEEEEEEE-----------EEEEEEEE----------EEEEEEEEEEE----------EEEEEEEEE----EEEEEEE--EEEEEE--EEEEEE--------EEEE---EEEEEEEEE--EEEEEEE---EEEEEEE----EEEEEE-------EEEEEEEE-----EEEEEE----EEEEEE-----------EEEEEEEEE------EEEEE--------------------EEEEEE---EEEEEEE--HHHHHHHHHHHHHHHHH--------HHHHHH--------------EE-HHHHHHHHH--HHHHHHHHHHH---HHHHHHHHHHHHHHHH-- CPSF1_1C soprano -------EEEEEEEEE--------EEE------------------EEEEEE------EEEEEE-----EEEEEEE------EEEEE---------------------------------EEEEEEE---EEEEEE----EEE----------EEEEEE-----EEEEE----EEEEE----EEEEE-----EEEEEEE---EEEEEE----EEEEEEE-------EEEEE-----------EEEEEEEE-----EE-------------------------------------------------------------------------EEEEEEE---EEEEEE-----EEEEE--------EE-----------------H---------HHHEEEEE--------EEEEEE---EEEEEEE-----------EEEEEE-----------------------------------EEEEE-------EEEEE----EEEEEE----EEEEE------EEEEE----------EEEEE---EEEEEEE-----------EEEEE------EEEEE----EEEEEEE------------------H--------------EEEEEEE------E---EEEE-----EEEEEEEEEE----------EEEEEEEEE----------EEEEEEEEEEE----------EEEEEEEEE----EEEEEE---EEEEEE--EEEEEE-----EEEEEEE---EEEEEEEE---EEEEEE----EEEEEEE----EEEEEE------EEEEEEEEE----EEEEEE-----EEEEEE-----------EEEEEEEEE------EEEEE-------------------EEEEEEE----EEEEE---HHHHHHHHHHHHHHHHH--------HHHH----------------EE-HHHHHHHHH--HHHHHHHHHHH---HHHHHHHHHHHHHHHH-- CPSF1_1C consensus MSCVHYKFSSKLNYDTVTFDGLHISLCDLKKQIMGREKLKAADCDLQITNAQTKEEYTDDNALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPAMATTKAIDDSSASISLAQLTKTANLAEANASEEDKIKAMMSQSGHEYDPINYMKKPLGPPPPSYTCFRCGKPGHYIKNCPTNGDKNFESGPRIKKSTGIPRSFMMEVKDPNMKGAMLTNTGKYAIPTIDAEAYAIGKKEKPPFLPEEPSSSSEEDDPIPDELLCLICKDIMTDAVVIPCCGNSYCDECIRTALLESDEHTCPTCHQNDVSPDALIANKFLRQAVNNFKNETGYTKRLRKQLPPPPPPIPPPRPLIQRNLQPLMRSPISRQQDPLMIPVTSSSTHPAPSISSLTSNQSSLAPPVSGNPSSAPAPVPDITATVSISVHSEKSDGPFRDSDNKILPAAALASEHSKGTSSIAITALMEEKGYQVPVLGTPSLLGQSLLHGQLIPTTGPVRINTARPGGGRPGWEHSNKLGYLVSPPQQIRRGERSCYRSINRGRHHSERSQRTQGPSLPATPVFVPVPPPPLYPPPPHTLPLPPGVPPPQFSPQFPPGQPPPAGYSVPPPGFPPAPANLSTPWVSSGVQTAHSNTIPTTQAPPLSREEFYREQRRLKEEEKKKSKLDEFTNDFAKELMEYKKIQKERRRSFSRSKSPYSGSSYSRSSYTYSKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHGYHRSRSRSPPYRRYHSRSRSPQAFRGQSPNKRNVPQGETEREYFNRYREVPPPYDMKAYYGRSVDFRDPFEKERYREWERKYREWYEKYYKGYAAGAQPRPSANRENFSPERFLPLNIRNSPFTRGRREDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKND GSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQKVKSVTV RBBP6_1 sequence --EEEEEE-------EEEE------HHHHHHHHHHH---------EEEEE------------EE----EEEEEEEE---------EEEE------------------HHHHHHHHHHHHHHHH---HHHHHHHHHHH-------------------------------------------------------------EEE---------EE-----EEEE---HHHHHHH-------------------------------------------------HHHHHHHHH-----------------------HHHHHHHHHHHHHHHHHHHHH---------------------------------------------------------------------------------EEEEEEE-----------------HHHH----------HHHHHHHH----------------------------------------------------------HH-------EE------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------------------------------------------------------------------------------------------------------------HHHHHHH------------------------HHHHHHHHHHHHHHHHHHHHHHH-------------------------------------------------------------------------HHH-------------HHHHHH------------HHHHHHH----------------EEE--------------- RBBP6_1 psipred --EEEEEEE------EEEE---EE-HHHHHHHHHHHH--------EEEE-------------EE----EEEEEEE-----------EEE-------------------------------------HHHHHHHHHHHHH-------------------EEEEE------EEE-----------------------HHHHH---------EEEE----EEEEE--HHHHHHHHHH---------------------------HHHH-------------HHHHHHHHHHH-----------------------HHHHHHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_1 prof --EEEEEEE------EEE-----HHHHHHHHHHHHH--------EEEEE------------EEEE---EEEEEEE----------EEEE------------------------------------HHHHHHHHHHHH---------------------EEEEE------------------------------------EEE------EEEEE----EEEEE--HHHHHHHHH------------------------------------EEE--------HHHHHHHH------------------------HHHHHHHHHHHHHHHHHHHHH------------------------------------------------------------------------------------EE-----------------------------------EEE----------EE-------------------------------------------EEE------------EEE-------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHH--------------------------------------------------------------------------------------------------------------------------HHHH-------------------------------HHHHHHHHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------EEEEE-------------- RBBP6_1 jnet --EEEEEE-------EEEE---EEEHHHHHHHHHHH-------EEEEEE-------------EE----EEEEEE----------------------------------------------------HHHHHHHHHH-----------------------EEEE--------------------------------HHHHH---------EEE-----EEEE----HHHHHHH------------------------------HHHHH------------HHHHHHHH-------------------HH----HHHHHHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHH------------HHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------EEE--------------- RBBP6_1 sable -EEEEEEE----EEEEEEEE-EEE-HHHHHHHHHHHH------EEEEEEE----EEE----EEEE--EEEEEEEEEE-------------------------------------------------HHHHHHHHHHHHHHHH-------------------------------------------------------------------EEE----EEEEE---HHHHHHHHHHHHHHHHHHHH--------------------------E----------------------E-------------------HHHHHHHHHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHH---------------------------------------------------------------------------------------------------HHH----------------------------------------------------- RBBP6_1 proteus --EEEEEE-------EEEE------HHHHHHHHHHHH---------EE-----HHH------------EEEEEE------------HHH--------------------HHHH----HHHHH----HHHHHHHHHHH-------HHHH-----------EEE-------EEE-----------------------HHH-EE---------E------EEEE---HHHHHHH-H------HH-------------HH----HHHHH----EE---------HHHHHHHHH----------------HH-----HHHHHHHHHHHHH----------------------HHHHH------------------E-------------------------------------------EE---E-----------------HHHH----------HHEEHH-------E--E-------------------------EEE------------------------EEE---EEEEE------EEEEE------------------------------------------------------------------------EE---------------------HHHH-----EE--HHH---------------HHHH-----------E-E----------------------------------------------------E----------------------------------------------------HHHH---------HHHEEEEEEE-------HH----HHH-------------------------------HHH--------------------------------------------------------------------------------------HHHH------------------EEEE--------------- RBBP6_1 sspro4 --EEEEEEE------EEEE------HHHHHHHHHHHH-------EEEEE-------------EE----EEEEEE----------------------------------------------------HHHHHHHHHHH-------------------------------------------------------------------------EE-----EEEE---HHHHHHHHH---------------------HHH-------------E---------HHHHHHHHHH---------------HHH----HHHHHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_1 psspred -EEEEEEE-------EEEE------HHHHHHHHHHHH-------EEEEEE------E----E-----EEEEEEEE---------EEEE----------------------HHHHH-HHHHHHH---HHHHHHHHHHH--------------------------------E-------------------------HHHEEE--------EEEE---EEEEEE--HHHHHHHHH-------------------------------------E---------HHHHHHHHHH---------------HHH----HHHHHHHHHHHHHH----------------------------------------------------------------------------------------------------------------HHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------H-HHHHHHHHHHHHHHHHHHH--------------------HHH-------------------------------------------------HHHHHHHH------------HHHHHHHH--HH-----HHHHHHHH----------------E---------------- RBBP6_1 spineX --EEEEE--------EEEE------HHHHHHHHH-H---------EEEE-------------E-----EEEEEE-----------EEEE------------------------------HHHH---HHHHHHHHH------------------------E---------E-------------------------HHHHH----------EEE----EEEEE--HHHHH-------------------------HHHH-----------EE---------HHHHHH--------E------------HEE-----HHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHH-------------------------------------------------------------------------------------------------------------HHH------------------------------------- RBBP6_1 raptorxss -EEEEEEE------EEEEE------HHHHHHHHHHHH-------EEEEE-------------EEE---EEEEEE---------------------------------------------HHH----HHHHHHHHHHH---------------------EEEE-------EH----------H-------------HHHEEEE-------EEEE----EEEEE--HHHHHHHHHH-------------HHH-------E------H----EE---------HHHHHHHHH-----E----------HHH----HHHHHHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHH-HHHHHHHHHHHHHH--------------------------------------------------------HHHHH-----------HHHHH---------------HHHHHH----HH-----------------------------EEE-------------- RBBP6_1 SPARROW --EEEEEE-------EEEE----E-HHHHHHHHHHH--------EEEEE-------E-----E-----EEEEEE------------E---------------------------------------HHHHHHHHHHH-------H--------------E-----------------------------------HHH-----------EEE-----EEEE---HHHHHHHHHH------------HH----------------------E---------HHHHHHHHHH-----------------H----HHHHHHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ RBBP6_1 *SPARROW --EEEEEEEE-----EEEEE--EEEHHHHHHHHHHHHH-----EEEEEE------EE-----E-----EEEEEE------------EEE---------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHH-----------------------H--H---EEEE-----------------------HHHHHEE-------EEE-----EEE----HHHHHHHHHHHHHHHHH-------------HHHH-HHHHHHHHH-EEE---HHHHHHHHHHHHHHHH-----HH-H-------H-E-HHHHHHHHHHHHHHHHHHHHHHHH--------------HHH-------------------------------------------------------------EEEEEEE--------EE-----EE-HHHHHHH------HHHHHHHHHH-----------------------------EEEE-----------------EEEE--HHHHHH--HHEEE-----------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----------------EEE------------------H------------------------------------------------------EE-----------HHHHHHHHHHHHH------HHHHE-----------HHHHHHHHHHHHHHHHHHHHHH-------------H---HH----------------------------------HHHHHH------------HHHHHHH----------HHHH-HH----------HHHHHHHH--------HH----EEEE--------------- RBBP6_1 HMMSTR -EEEEEEEE------EEEE----EEHHHHHHHHHHH---------EEEE----HHH------------EEEEEEE----------EEEE---------------------HHHHHHHH-HHH----HHHHHHHHHH-----------------------EEEE------EE----------------E-------HHHEEE---------EE-----EEEEE--HHHHHHH-------------------------EE----HHHH----E------HHHHHHHHHHHH-----E-----------------HHHHHHHHHHHH-----HHHH-----------------------------------EE--------------------------------------------------------------------HHHH----------EEEEEE--------------------------------EE---------------------E---------------------------------------------------------------------------------------------------------------------------HHHH-HHHHHHH-HHH-------------HHHHHH-----------------------------------------------------------------------------------------------------HHHH--------------------------------------------HHHHH-HHHHHHHH-HHHHH-----------------------------------------------------------HH-H----------------------------------------------HHHHHHHHH-------------EEEEE-------------- RBBP6_1 spine --EEEEEE--------------EEEE-------------------EEE---------------------EEEEEE----------EEEEE--------------------HHHHHHHHHHHHH----HHHHHHHHH------------------------EE----------------------------------EEEEE---------EEE--------------------------------------------EEEE--------EEEE-----------HHHHH------------------HHHHHHHHHHHHH------------------------------------------------EEEE------------------------------------------EEEEEE------------------HHHHH--------EEEE----------EEE-----------------------EE-------------------EEE--------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHH------------------------EEE---------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------EEEE-------------- RBBP6_1 nnssp ---------------EEEE--EEEEHHHHHHHHHHHHHHHH----EEEE-------------------EEEEEE------------EEEEE--HHHHHHHHHH-------HHHHHHHHHHHHH---HHHHHHHHHHH----------------------------------------------------------HHHHHHH------EEEEE-----------HHHHH-------------------------HHHHHHHHHHH----EEEE-------HHHHHHHHHH---------------HHHHHHHHHHHHHHHH--------HHHHHH---------------------------------EEEEE--------------------------------------EEEEEEEEEEE---------------HHHHHHHHH-----HHHHHHHHHHH---------HHHHHHHHHH---------EEEEEE-------------------------------EEEEEE--------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------------------EEEEE---------------------------------------------------------------------------------------HHHHHHH----------------------HHHHHHHHHHHHHHHHHHHH---------------------HHH--------------------------------------------------------------------------------------HHHHHHHHH-------------EEEEEE------------- RBBP6_1 pssfinder ---EEEEE-EEE----------EEEE----EEE-------EEE--EEEEE--EEHHHHHHH-------EEEEEEEEE--EE---EEEEEE-----EEEEE----------HHHHHHHH-HHHH---HHHHHHHHHH--------EE-------------EEEE---------------------------------EEEEEE--------------EEEEEE--HHH-----------------------------EEEEE-----EEEEEEE-----HHHHHHHEEEEE-------------------HHHHHHHHHHHH-EE-----HHH------------------HHHHH--------------EEEE------------EE--------------------------EEEEEEE------------------HHHH---------------EE-------------EE--EE----EE------EEE-------------------EEE----EE----EEEE-------------------------EE----------------------------------------------------------EE---------------------HHHHHHHHHHHHHHHH----------HHHHHHHHHHH--HHH----------------------------------------------------------------------------------------------------------------HHHHHHHH----------------EE------HHHHHHHHHHHHHHHHHH-----------------------EE---------------------HHHHHH---------------------------------------------------------HHHHHHHH--------------EEEEEE------------- RBBP6_1 sspal --EEEEEEE----EEEEEEE-EEEEHHHHHHHHH-----------EEEE--------------------EEEEEEE---EEEEEEEEEEE----------------HHHHHHHHHH---HHHHHHHHHHHHHHHH-----------------------EEEEE--------------------------------EEEEEEEE------------------HHHHHHHHH------------------------HHHHHHHHH-----EEEE---------HHHHHHHHH----------------HHHHH-HHHHHHHHHHH----HHHHHHHHH------------HHHHHHHHHHH---------EEEEEEE------------------------------------EEEEEEEEEE-------------HHHHHHHHH------EEEHHHHHHHHH--EEEEEEE--------------------EEEE---------------EEEEEEE--------------------------------------EEEEE-------------------------------------EEEE--------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHH------------------EEEE----------EEEEEEE-----------------------------------------------------------------------HHHHHHHHHH-----------------HHHHHHHHHHH--HHHHHHHHHH-------------------------------------------------------------------------------------------HHHHHHHHH---------HHHHH------------------EEEE-------------- RBBP6_1 ssp ----------------------------HHHH----------------------------------------------------------------------------------------------HHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------HHHH-----------------------------HHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- RBBP6_1 sspred --EEEEEE-------EEEE------HHHHHHHHHHH--------EEEEE-------------------EEEEEEE----------EEE--------------------------------------HHHHHHHHHHHH---------------------EE----------------------------------HHHHHH-------EEEEE----EEEE---HHHHHHHHHH----------------------------HHHH--------------HHHHHHHHH-----------------------HHHHHHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ RBBP6_1 netsurfp --EEEEEE--------EE-------HHHHHHHHHHHH-------EEEEE-------------E-----EEEEEEE----------EEEE------------------------------HHH-----HHHHHHHHHHHHH-------------------EE--------------------------EE----------E---------EEE-----EEEEE--HHHHHHHHHHHHHH-H------HH---------------------EEE--------HHHHHHHHHH----E-----------------HHHHHHHHHHHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-----E------------HHHH-------------------EE--------------- RBBP6_1 soprano --EEEEEE-------EEEE----E-HHHHHHHHHHH--------EEEEE-------------E-----EEEEEEE----------EEEE------------------------------HHH----HHHHHHHHHHH----------------------EE----------------------------------HHH-EE--------EEE-----EEEE---HHHHHHHHH------------------------------------EE---------HHHHHHHHH------------------H----HHHHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHH--HH------HH-------------HHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHH--------------------------------------------------------------------------------------------------------------HHH-------------------EEE--------------- RBBP6_1 consensus MHGGGPPSGDSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDPRQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKLLVDSNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGEEMDNKFGVEQPEGDEDLTKEKGHGGCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGMEPRYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQNGAAAHVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVDFSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQYPGAKYIIRDNGDRIDLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWSTFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQDTLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHINCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHISYLEMGHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKAHNNELEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKINISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHAMGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGESVEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELEREFERMREDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKLVIVN GDDPLSRQAQENATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAIAHPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLTVFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMPDFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIRIMNSDENKMQEEEEVVDKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKIIITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALERELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLMEAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGMEIPTNIPGLGAAGPTGMFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDASGFSPGYSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPTSPSYSPTSPSYSPTSPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPASPKYTPTSPSYSPSSPEYTPTSPKYSPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTSPKYSPTSPTYSPTSPKYSPTSPTYSPTSPKGSTYSPTSPGYSPTSPTYSLTSPAISPDDSDEEN RPB1_1 sequence --------------EEEEEEEEEE---HHHHHH------------------------------------------------------------------HHHHHHHHHH--------------HHHHHHHHH----HHHHHHHHHHHH------------------------------------------EEEE--EEEEEE---------------HHHHHHHHH---HHHHHHH----------EEEEEEE----------EEE---------HHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH-----------------HHHHHHH--------------------------------------HHHHHH--------HHHHHHHHHHHHH---------EEE-----EEEE---------------EEEEE-----EEEE-------------EEEEE--------------------------------HHHHHHHHHHH-----EEE------EEEEEEEEEEEEEE---------HHHHHHHHH----------------------HHHHHHH--------------------------------EEEEE--EEEEEEE-----------EEEHHHHHH-HHHHHHHHHHHHHHHHHHHHH---EEEE------HHHHHHHHHHHHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHH---HHHHHHHHHHHHH--EEE------------------------------------------HHHH---------HHHHH---HHHHHHHHHHH---EEE------------EEEE-----------------------HHHHHHH-------HHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHH-------------HHHHHH-- RPB1_1 psipred --------------HHHHHHEEE----HHHHH--EEE---EEE---------------------------------------------------EEHHHHHHHHHHHHHHHHH---EE-----HHHHHHHHHH---HHHHHHHHHHHH----EE------------------------------------HHHH--EEEEEEE----------EE--HHHHHHHHHH--HHHHHH-----------EEEEEEE---------EEEE-------HHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHH----------HHHH-----HHHHHHHH-----EEEE-----EEEEEEEEEEE-------------HHHHH------------HHHHHHHHH---------EEEEE----EEEEEEE-----EEEE---EEEEEEE---EEEEE----HHHHHH----EEEE--EEEEEEEEE--------------------HHHHHHHHHHHH---EEE-------EEEEEHHHHHHHHHH--------HHHHHHHHHH------------EE----------EEEEEE----EEEE----------------------EEEEE--EEEEEEEEEEEEE-----EEEEEE----HHHHHHHHHHHHHHHHHHHHH---EEE-------HHHHHHHHHHHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHHHHH-HHHHHHHHH----EEEEEE-----EEEEEEEEEEEEEEEEE-EEE----------------------------------HHHHHHH-------HHHHHHHHH---HHHHHHHHHHHHHHHH---EEE-----EEEEEE-------HHHHH----------HHHHHHEEE-------------HHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHH------------HHHHHHH-- RPB1_1 prof -------------------EEEEEE--HHHHH--EEEEE--EEEEEE--------------------------------------EEEEE---EEEE--HHHHHHHHHHHHHH----E-----HHHHHHHH------HHHHHHHHHHH-----------------------------------------EEE----EEEEEE---------------HHHHHHHH----HHHHHH-----------HHHH-E-----------EE--------HHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHH-EEEEE----------------HHHHHHHHH------E-------------------------------HHHH------EE--HHHHHHHHHHHH---------EEEEE----EEEE--------------EEEEEE-----EEEEE-------------EEEE---------------------------------HHHHHHHHHH------E-------EEEEEE-HHHHHHHHH----E-HHHHHHHHHHH-----------------------EEEEEEE---EEEEE----------------------EEEEE---EEEEEEEEEEEEE----EEEEEEE----HHHHHHHHHHHHHHHHHHHH---EE--------HHHHHHHHHHHHHHHHHHHHHHHHHHH---------HHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----EEEEEEE------EEEEEEEEEE----E----------------EEE---------EEE---------EEEEEE-----------EEE-----HHHHHHHHHHHHHHH-----EE-----EEEEE--------EEEE----------HHHHHHHH-------------HHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHH------EEE----HHHHH-- RPB1_1 jnet --------------EEEEEEEEEE---HHHHHH--EEEEEE---------------------------------------------EEEE------HHHHHHHHHHHHHHHHHH--EE-----HHHHHHHH-----HHHHHHHHHHHHH---------------------------------------HHHHHH-HHHHHHHHHHHHHHH-------HHHHHHHHHHH-HHHHHHH----------EEEEEEEE--------EEEE--------HHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHH--------------------HHHHH---------------------EEE---------EEE--HHHHHH--------HHHHHHHHHHHHH--------EEEEE----EEEEE--------------EEEEEE----EEEE-------------EEEEE----EEEE------------------------HHHHHHHHHHH-----EE-------EEEEHHHHHHHEHEEH-------HHHHHHHHHHH--------------------HHHHHHHH-------------------------------EEEEE--EEEEEEE---------HHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHH----E--------HHHHHHHHHHHHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHHHHHHHHHHHHHHH------HHEEEE------HHHHHHHHHHHHHHH-----------------------------EEE---------HHHHHHH-----------E------HHHHHHHHHHHH-EEE---EEE-----EEEEE--------HHH-----------HHHHHHH-------------HHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHH-------EE---HHHHHHHH RPB1_1 sable -------------------EEEEEEE-HHHHHH--EEEEE-------------------------------------------EEEEEEE--EEEEHHHHHHHHHHHHHH-------------HHHHHHHHHHH---HHHHHHHHHHHHH--EEE-----HHHHHHHHE-------E-EEE----EEEHHHHHH--EHHHHHHHHHH----------HHHHHHHHHH--HHHHHH---------HHHHEEEEEEEE----EEEEEE----------HHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHH--------------------EE--------HHHHH--------EEEEEEEEE------EEEE-HHHHHHE--EEEEE---HHHHHHHHHH------EEEEEEE---EEEE---------------EEEEEEE---EEEEEEE--------EEEEEEEEEE---EEE---HHH--------EEEEEEE---HHHHHHHHHHH------------EEEEEEE-HHHHH-EEHH---EEE-HHHHHHHHHHH----------------EEEEHHHHEEEE-----EEEEE--------------------EEEEEH----EE----HHH------HHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHH------------HHHHHHHHHHHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHH-----HHHHHHHHHH--EEE----EEE-----------------HHH--EEEEE------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--EEEE---EEEE---EEEEEE---------EEEE-E-------HHHHHHHH-------------HHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHH------EEEEE-HHHHHHHH- RPB1_1 proteus ----------------EEEEEEEEE--HHHHHHHHEEEEE-----------------------------E----------------HHHH---EHEHHHHHHHHHHHHHHHHH---EE-----HHHHHHHHHH---HHHHHHHHHHHH------------------------------------------EE----EEEEEEE----------EE--HHHHHHHHH---HHHHHHH-----------EEEEE----------EEEE--------HHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHH--------HHH------HHHHHHHH------EE------EEE--EEEEE--------------HHHHHH--------H--HHHHHHHHH---------EEEEE----EEEEEEE------E-----EEEEE-----EEEEE------H------EEEEE---EEEEEEE---------------------HHHHHHHHHHHH-----E-------EEEEEEHHHHHHHHH--------HHHHHHHHHH------------E----------HEEEEE-----EEEE----------------------EEEEE--EEEEEEEE----------EEEEEE----HHHHHHHHHHHHHHHHHHHHH---EEE-------HHHHHHHHHHHHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHHHHHHHHHHHHHHHH------EEEEEE-----EEEEEEEEEEE--------E-------------------------EE--HH----HHHHHHHH-------E--HHH-HHHHHHHHHHHHHHHH-EEEE---EE-----EEEEEE------HHHHH----------HHHHHHHEEEE----H-------HHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHH-------------HHHHHH-- RPB1_1 sspro4 --------------EEEEEEEEEEE--HHHHHHHHEEEEEEE-------------------------------------------EEEE--------HHHHHHHHHHHHHHHH--EEE-----HHHHHHHHH----HHHHHHHHHHHHHHHEE-------------------HHHHH----------HHHHHHH---HHHHHHHHHH----------HHHHHHHHHH--HHHHHHH--------HHHEEEEEEE------EEEEE---------HHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHH------------------HHHHHH----------------------E----------EE---HHHHHHH---EEE-HHHHHHHHHHHHH---------EEE-----EEE------HHHHH----EEEEEEEE---EEEE----HHHHH----EEEEEE---EEEEE---------------EEEE----HHHHHHHHHHH-----EE-------EEEEEHHHHHHHHHHH-------HHHHHHHHHHH-----------EEEEEEE----EEEEEEE------EE----------------------EEEEE--EEE-----HHH------HHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHH--EEEE--EE--HHHHHHHHHHHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHH-----HHHHHHHHHHHHH--------------------------------HHH-------HHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHH-EEEEE---EE----EEEEEEE---EE--EEE-----------HHHHHHHH-----------HHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHH--------E---HHHHHHHH- RPB1_1 psspred ---------------EE--EEEEE---HHHHHHHH--EE-E---------------------------------------------EE--------HHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHH----HHHHHHHHHHHHHH-----------------------HHHH------------------HHHHHHHHHHH--HHH------HHHHHHHHHH--HHHHHHH----------EEEEEEEE------EEEEEE--------HHHHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHH------HHHHH-------HHHHH--------------E------EEE--------------HHHHHH----EE--HHHHHHHHHHHHH---------EEEE---EEEEEE-------------EEEEEE----EEEEE--------HHH---EEEE----EEEEE-----------------------HHHHHHHHHHHH----EE------EEEEHHHHHHHHHHHHH-------HHHHHHHHHHH--------------------HHHHHHHH------EE-----------------------EEEEE--EEEEEEE-----------HHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHH-EE-----E---HHHHHHHHHHHHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHH-----HHHHHHHHHHH--------------------------------------------HHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHEEEE----EEE---EEEEEEE------HHH------------HHHHHHHH------HHHHHHH--HHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHH--------E--E-HHHHHHH- RPB1_1 spineX ---------------EEEEEEEE----HHHHHHH--EEEEE---EE-----E------------------EEE--------------EE---HHHHHHHHHHHHHHHHHHEEE------------EEEEEE-----HHHHHHHHHHH----EE------------------------------------EEEEE--EEEEEE----------EEEE-HHHHHHHHH---HHHHHH-----------EEEEEEEE--------EEEE----EEE----HHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH-------------------HHHH----------------------EEE------------------EEEEEEEEE----HHHHHHHHHH--------EEEEE----EEE------HHHH------EEEEEE----EEE----------------EEE-----EE----------------H--------HHHHHHHHHH----HEEE-------EEEEEE-EEEEEEEEE-------HHHHHHHHHH------------------EE---EEEEEE-------------------------------EEEEE--EEEEEEE---E-------HHHHHHHHH-HHHHHHHHHHHHHHHHHHHHH---EE--------HHHHHHHHHHHHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHHHHHHHH-HHHHHH-----HHHHHHH---------HHHHHH----EEE---E-----------------------------------HHHHHHHHH------E----------HHHHHHHHHHH--EEEE--EEE-----EEEEEE-------EE------------HHHHHHH----------------HHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHH-------EE-----EEEEE-- RPB1_1 raptorxss -------------EEEEEEEEEE----HHHHHHH-EEEEEE----E------E----------------E----------------EEE---H-----HHHHHHHHHHHHHHH----------HHHHHHHHH----HHHHHHHHHHHH-------------------------HH---------------HHHHHHHHHHH-HHHHH---HHH----HHHHHHHHHH--HHHHHHH----------HEEEEEEEE------EEEEE--------HHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHH--------HHH---------HHHHH---------------E-----EEE-------E-EEE--HHHHHH----EE--HHHHHHHHHHHH---------EEEE-----EEE-----HHHHHH-----EEEEE-----EEEE-------HHHHH--EEEE-----EEE----------------EEEE----HHHHHHHHHH-----EEEE-----EEEEEHHHHHHHHHHHH-------HHHHHHHHHH--H------------------HHHHHHHH------EEE----------------------EEEEE--EEEEEEEEHHEE------EEHHHHHHH-HHHHHHHHHHHHHHHHHHHHH----E----EEE-HHHHHHHHHHHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHH----HHHHHHHHHHHH-EEEEEEE--------EE---------------EEE--E------HHEHHHHHH-HH-HEEHEE------HHHHHHHHHH--EEE-----EE-----EEEEEE------HHHH-----------HHHHHHH-------HHHH-----HHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHH------E---E-HHHHHH-- RPB1_1 SPARROW ---------------EEE-EEE-----HHHHHHH--EEEEE----------E----------------------------------------------HHHHHHHHHHHH------------HHHHHHHHHH----HHHHHHHHHHHHH----------------------------------------EEEHHHHHHHHH----------------HHHHHHHHHH--HHHHHH---------HHHEEEEEEE-------EEEE-----E---HHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHH---------H--------HHHHHHH---------------------EEE------------H-HHHHHH--------HHHHHHHHHHHHH-------EEEEE-----EEE------HHHHH-----EEEE------EEEE--------------EEEE----EEEE------------------------HHHHHHHHHHH-----EE-------EEEEEEHHHHHHHHHH-------HHHHHHHHHH----------------------HHHHHHH------EEE----------------------EEEEE--EEEEEE---HH-------HHHHHHHHH-HHHHHHHHHHHHHHHHHHHHH----E-HHH----HHHHHHHHHHHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHHHHHHHHHH--------HHHHHH----HHH--HHHH-E-----HH---E--------------------H-------H-------HHHHHHHH---HHH--------HHHHHHHHHHHHHH-EEEE---EEE-----EEEEE-------HHHHH----------HHHHHHHH---------------HHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHH-----------E-HHHHHH-- RPB1_1 *SPARROW --------------HHHEEEEE-----HHHHHHEEEEEEE---HHHHH------------------H-H--HHHH----------EEEEEE---EE---HHHHHHHHHH-----H--E-----HHHHHHHHHHHH-HHHHHHHHHHHHHH-EE-------------------------------------HHHH--EEEEEEE-------H---EEEHHHHHHHHHH--HHHHHH-----------EEEEEEE----------EEEE-----HHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHEEEEE---------HHHH----HHHHHHHH------EE------EEEEEEEEEEEE-----HHH----HHHHHHHH----E----HHHHHHHHHH--------EEEEEE---EEEEEEHHH-HH-EE----EEEEEEE---EEEEE-----HHHHHH--EEEEEE--EEEEEEEEE------E----EEEE---HHHHHHHHHHHHH---EEE-----------HHHHHHHHHHHHHH-HHHHHHHHHHHHHEE------------------EE--EEEEEE-----EEEEE---------------------EEEEE---EE---------------EEEEEEE---HHHHHHHHHHHHHHHHHHHE-----EE-------HHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------HHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHE------EEEHHHHHHHH---EE------------------E---------EEE--E-----HHHHHHHHH-----EEEEEEE------EEHHHHHHHHHHHEEE---EE-----EEEEEE------EEEEE-----EEE--HHHHHHEEEEEE-------HHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHH----------HHHHHHHH RPB1_1 HMMSTR --------------E----EEEE----HHHHHHH---------------------------------------------------EEEEE---EE-HHHHHHHHHHH--E------E------HHHHHHHH-----HHHHHHHHHHHH----E-------------------------E-------E----EEE--EEEEEE-----------EEE-HHHHHHHHHH--HHHHHH---------HHH-EEEEEEE--HHH---------------HHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHH--------------------HHHHH--------HH----E---EEEEEEEE-------EEEEEHHHHH--EEEEE-----HHHHHHHHHH-------EEEEE-----E------------------EEEEE-----EEEEE------HHHEEEEEEEEE----EEE-HHHHHHH-------EEEEE----HHHHHHHHHH-EHHHH-EE----EE------HHHHHHHHHH----EEEHHHHHHHHHH------------E-----EEEHHHHHH--------EEE-----------------------EEEE---EEE----HHHH------HHHHHHHH--HHHHHHHHHHHHHHHHHHHHH------HHHH----HHHHHHHHHHHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHH-----HHHHHHHH-------E--E-----E--E-----------------E---------HHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHH---EE-----EE-----EEE--HHH--E-HHHEEEEE---H---HHHHHHHH-----------HH--------------HHHHHHHHHHHHHHHHHHHHHH------EEEEE--HHHHHH-- RPB1_1 porter -------------------EEEEE---HHHHHHH-EEEEE-----E-----------------------EEE--------------EEEE------HHHHHHHHHHHHHHHHH--EEEE-----HHHHHHHH----HHHHHHHHHHHH----E-------------------HHHHHHH---------HHHHH---HHHHHHHHHHHHHHHHH----HHHHHHHHHH--HHHHHHH----------EEEEEEE---------EEEE--------HHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHH-------HHHH-------HHHHHHHH-----HHHHH----------EEE------E-------HHHHHH--------HHHHHHHHHHHH---------EEEEE----EEEE------HHHH-----EEEEE-----EEEE----HHHHH----EEEEEE---EEEE--E------------EEEEE--H-HHHHHHHHHHHH----EE-------EEEEHHHHHHHHHHH--------HHHHHHHHHHHH--------------EEEEE--EEEEEE-------E---------------EE------EEEEE--EEEEE---------HHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHH--EEEEE--EE--HHHHHHHHHHHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHHHHHHHHHHH-------HHHEEE------HHHHHHHHHHHHHHH----E------------------------HHHH-HH----HHHHHHHHH----HHHHHHHH-----HHHHHHHHHH--EEEEE--EEE----EEEEEEE-------EE------------HHHHHHHHH-----HHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHH-------EE--E-HHHHHH-- RPB1_1 spine -----------------------------HHHHH-------------------------------------------------------------EE-EEE-------EEEEE------------HHHHHHH----------EE---------------------------------------------------HHHHHHHHH--------EEEE-HHHHHHHHHHH-----EEE-----------EEEEE-----------EEE-------HHHHHHHHHHHHHHHHHHH------HHHHHHH-HHHHHHHHHHHH--------HHHHH----HHHHHHHHH--------------------EEE-------------------------------HHHHHHHHHH---------EEEE----EEEEE--------------EEEE------EEEE---------------EEE--------------------------------HHHHHHHHHHH-----EE-------EEEEE--HHHHHHHH----EE-------HHHHHH-----------------------EEEEE------EE-----------------------EEEEE---EEEEEE-----------EEEEE-------HHHHHH--HHHHH---EEE--------------HHHHHHHHHHHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHHHHHH-----HHHHHHH-----EEEE-----------EEEEEE-----------------------------------------------EE---------HHHHHHHHH----HHHHHHHHHHHHHHH--------HHHHHHHH-----------------------HHHHHHH------HHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHH---EEEEE-------EEE---HHHHHHHH RPB1_1 nnssp ---------------------------HHHHHHH------------------------------------------------------EEEEEEE-HHHHHHHHHHH----------------HHHHHHHHHH----HHHHHHHHHHH----------------------------------------------HHHHHHHHHH--HHHHHHHHH--HHHHHHHHHH--HHHHHH---------HHHHEEEE----------EEEE------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----------------------HHHHHHHHHHHHHHHH-------EEEEEEEE-------EEEEEHHHHHHHHHHHH-----HHHHHHHHHH-------EEEEE------------------------EEEEE-----EEEEE---------EEEEEEEEE----EEE-HHHHHHH-------EEEEEE---HHHHHHHHHHHHHHHH--------------HHHHHHHHHHH---EEEEHHHHHHHHHH------------------EEEHHHHHHHH----EEEEEEE-------------------EEEEEE--EEEEEEEEE---------EEEEEEEEE---EEEEEE--HHHHHHHHHHH----------------HHHHHHHHHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHHHHHHHH--HHHHHHHHH---EEEEEE-----EEEEEEEEEEE--------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------EEE-----EEEEEE---------HHHHHHHHH-HHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---EEEEEEE----EEEE-HHHHHHHH-- RPB1_1 pssfinder ---------------HHHHHEEEE---HHHHHHHH---------------------------HHHHHHHHHHH-------------EEE-------HHHHH-HHHHHEEEEE-----------HHHHHHHHH---------HHHHHH-----HHH-----------------HHHHHHH---------HHHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHH---EEEE----------EEEEEEE----------EEE------HHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHH----HHH------------------HHHHHHHHH-------------EE----EEEE--------------------HHHHHH-----HHHHHHHHHH--------EEEE-----EEEEEE------------EEEE-------EEEEE-------------EEEEEE----EEEEEE--------------------HHHHHHHHHH----EEEE-------EEEEHHHHHHHHHHHHHH--EEE---EEEEEEEE-EE-------------------EEEEEEE---EEEEE----------------------EEEEE--EEEEEE-----------EEEEEEE------HHHHHHHHHHHHH---EEE---EE-----------HHHHHHHHHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHHH--------HHHHHHHH----EEEEE-----------EEEEE----------EEEEE-----------------EEEE----------EEEE--------HHHHHHH-HHH-HHHHHHHHHHHHHHHH--HHHHH-HHHHH-------------------------HHHHHH--------HHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHH----EEEEEE-----EE----HHHHHHHH RPB1_1 sspal -------------------EEEEEEEE-HHHHHEEEE--------------------------------------------------HHHHH-EEEEEEEE----EEEEEEEE---EEEE----HHHHHHHHH----HHHHHHHHHHHH------------------------------------------HHHHHHHHHHHHH---HHHHHHEEEE-HHHHHHHHHH----EEEE----------EEEEEEE----EEEE--EEEE-HHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHEEE---------------------HHHHHHHHH--------------------EEEE--------------------------HHHHHHHHHHHHHH---------EEEE----EEEEEEE-----------EEEEEEE----EEEE--------------------EEEEEEEEEEE--------------HHHHHHHHHHHHHHH-----EEEE------HHHHHHHHHHHHHHH------HHHHHHHHHHHHH---------------------EEEEEEEE-------------------------------EEEE---EEEEEEE----------EEEE--------EEEEEEE-EEEEE--EEEE---EEEE------HHHHHHHHHHHHHHHHHHHHHHHHH------------HHHHHHHHHHHHHH--------HHHHHHHHH--EEEEEEE--------EEEEEEEE----------------------------------------------------------HHHHHHHHHH----HHHHHHHHHEEEEEHHHHHHHHHHHHHHHH---------HHHHHHHHHHH--HHHHHHHHHEEEE-HHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHH---EEEEEEE----EEEE----------- RPB1_1 ssp -------------------EEEEE----HHHHHH----------------------------------------------------EE-----------HHHHHHHHHHHHH----EEE-----HHHHHHHH-HHHHHHHHHHHHHHHHHHE-------HHH-HHHHHH------------------HHHHHHH----HHHHHHHHH-H-HH-----HHHHHHHHHH----HH----------------E--------------------------HHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHH------------------HHHH-----------------------------------------HHHH-----------HHHHHHHHHHH--------------------E----------------------------EEE------------------------------------------EEE------HHHHHHHHHH--------------EE---HHHHHH-----------HHHHHHHHHHH--------------------HHHHH--------------------------------------------------HHHH--HHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHH---EEE--------HHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHH------HHHHHHHHHHH--------------------------------------------HHHHHHHHH-------------------HHHHHHHHHHHEEE----------------------------------------HHHH------------------HHHHH------HHHHHHHHHHHHH----HE----------------HH-HH--- RPB1_1 sspred ---------------EEEEEEEE----HHHHHHHHHEEEEE-------------------------------------------------------HHHHHHHHHHHHHHHHHH---------HHHHHHHHH-----HHHHHHHHHHHH----------------------------------------EEEE---HEEEE------------EE--HHHHHHHHHH--HHHHHH------------EEEEEEE--------EEE---------HHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHH-------------------HHHHHH-----EE--------------EEE--------------HHHHH---------HHHHHHHHHHHHH--------EEEEE---EEEEEE----HHHHH-----EEEEE-----EEEE-------------EEEEE-----EEE------------------------HHHHHHHHHHHH----EEE-------EEEHHHHHHHHHHHH-------HHHHHHHHHHH--------------------HHHHHHHH-------E-----------------------EEEEE--EEEEEEE-----------HHHHHHHH--HHHHHHHHHHHHHHHHHHHHH---EEE-------HHHHHHHHHHHHHHHHHHHHHHHHHHH---------HHHHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHH-----HHHHHHHHHHH---E------------------------------E---------HHHHHHHHH-----HHHHHH-----HHHHHHHHHHH---EEE---EEE-----EEEEEE---------------------HHHHHHHH--------------HHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHH-------------HHHHHH-- RPB1_1 netsurfp ---------------EEEEEEEE----HHHH-HH--EEEEEE-------------------------------------------EEEEE-------HHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHH-----HHHHHHHHHHHHHH---------------------------------------H------H--EH------------E--HHHHHHHHHHH-HHHHHHH-----------EEEEEEE------EEEEEE---------HHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHH-------HH--------HH-EH----------------------EEE----------E-----EE-----------HHHHHHHHHHH---------EEEEE---EEEEEE--------------EEEEEEE---EEEE--------HHHH--EEEE----EEEE-----------H-HHHHHHH--H-HHHHHHHHHHHH----EEE------EEEEEEEEEEEEEEEE-------HHHHHHHHHHH--------------------HHHHHHHHH-----EEE----------------------EEEEE--EEEEEEE----E------EEEEEE-----HHHHHHHHHHHHHHHHHHHHH------------HHHHHHHHHHHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHHHHHHHHHHHH------HEEEEE-------E-EEEEEEEH--EH------------------------------EE-----------EHHHHHH-----------HHHHHHHHHHHHHHHH--EEEE--EEE-----EEEEEE------HHHH-----------HHHHHHHH---------------HHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHH------------HHEHHH-- RPB1_1 soprano ----------------EE-EEEEE---HHHHHHH--EEEE----------------------------------------------EEE-------HHHHHHHHHHHHHHHHH----------HHHHHHHHH----HHHHHHHHHHHH------------------------------------------HHHH--HHHHHHHH-------------HHHHHHHHHH--HHHHHH-----------EEEEEEE---------EEEE--------HHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHH------------------HHHHHHH---------------------EEE--------------HHHHHH--------HHHHHHHHHHHHH--------EEEEE----EEEE---------------EEEEE-----EEEE--------------EEEE-----EEE------------------------HHHHHHHHHHH-----EE-------EEEEEHHHHHHHHHHH-------HHHHHHHHHHH---------------------HHHEEEE------EEE----------------------EEEEE--EEEEEEE-----------EEHHHHHH--HHHHHHHHHHHHHHHHHHHHH---EE--------HHHHHHHHHHHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHE------HHHHHHHHHHH----------------------------------E---------HHHHHHHHH-----HHHHHHH-----HHHHHHHHHHH-EEEE----EE-----EEEEEE-------HHH-----------HHHHHHHH------------HHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHH--------E----HHHHHH-- RPB1_1 consensus MAWAKKVGGRAGQGRSLSRCDPIILDPEWLYGPPEGEGGPEGVGGETRASIHPPLRTGRHHQKVNHNIRGPEGSAKDAAPGGGGHHQAGPGQRGDEDGALQHLCGGGGGVGVSVGRGTGTSVAAEHPSLQVKLLELQELVLRLAGDHNEGHGKFLAAAQNPADDPAPGAPAPQELGAADKQGGFEDKIPKRRFSEMQNERREQAQRTVLIHCPEKISENKFLKYLSQFGPINNHFFYESFGLYAVVEFCQKESIGSLQNGTHTPSTAMETAIPFRSRFFNLKLKNQTSERSRVRSSNQLPRSNKQLFELLCYAESIDDQLNTLLKEFQLTEENTKLRYLTCSLIEDMAAAYFPDCIVRPFGSSVNTFGKLGCDLDMFLDLDETRNLSAHKISGNFLMEFQVKNVPSERIATQKILSVLGECLDHFGPGCVGVQKILNARCPLVRFSHQASGFQCDLTTNNRIALTSSELLYIYGALDSRVRALVFSVRCWARAHSLTSSIPGAWITNFSLTMMVIFFLQRRSPPILPTLDSLKTLADAEDKCVIEGNNCTFVRDLSRIKPSQNTETLELLLKEFFEYFGNFAFDKNSINIRQGREQNKPDSSPLYIQNPFETSLNISKNVSQSQLQKFVDLARESAWILQQEDTDRPSISSNRPWGLVSLLLPSAPNRKSFTKKKSNKFAIETVKNLLESLKGNRTENFTKTSGKRTISTQT PAPD1_2 sequence -HHHHH-------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHH--------------------------------------------------HHHHHHHHHH---EEEE-------HHHHHHHHHH-----EEEEE----EEEEEEE--HHHHHHHH--------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH----EEEE---------------EEEE----------------HHHHHH-----HHHHHHHHHHHHHHHHHHH-------EEE-------EEEEEE----EEEEEEE---HHHHHHHHHHHHHH--HHHHHHHHHHHHHHHH-------------HHHHHHHHHHHHHH----------------------------------------------HHHHHHHHHHHHH-------EEEE-------------EEEE--------------HHHHHHHHHHHHHHHHHHH------------------------------HH-----HHHHHHHHHHHHHH--------------EE----- PAPD1_2 psipred --HHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHH---EEEEE------HHHHHHHHHH------EEEE-----EEEEEE-----HHHHH--------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH----EEEE----------------EEEEE------------------------------HHHHHHHHHHHHHHH----EEEEEEEE----EEEEE------EEE-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHHH---------HHHHHH-------EEE----------HHH-------HHHHHHHHHHHHHHHEE-----EEEEE------------EEEE--------------HHHHHHHHHHHHHHHHHHHH---------------HHHH---------------------------------------------------- PAPD1_2 prof ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHH---EEEEEE------HHHHHHHHH------EEEEE----EEEEEE----HHHHHHHHH------------EEE----------------------------HHHHHHH-----HHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHH----EEEE--EEE---------EEEEEE-------------------------------HHHHHHHHHHHHHH-------EEEE----EEEEEEE-----EEEEEE---HHHHHHHHHHHHHHHH----HHHHHHHHHHHHHH-------------HHHHHHHHHH------------------------EEEE-------------------HHHHHHHHHHHHHH--------EEEE------------EEEEE--------------HHHHHHHHHHHHHHHHHHHH---------------------------------------------------------------EEEEE--- PAPD1_2 jnet --EEHH--------------------HHH------------------------------HHHHHHHHH-------HHH-------------------------------------------------HHHHHHHHHHHHHHHH--------------------------------------------------HHHHHHHH------EEE-------HHHHHHHHHH-----EEEE-----EEEEEEE-----HHHHH---------------------------------------------HHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHH----EEEE--------------EEEEEE-----------------------------HHHHHHHHHHHHHHHH-----EEEEEE------EEEEEE----EEEEEEE----HHHHHHHHHHHHHH-HHHHHHHHHHHHHHHH-------------HHHHHHHHHHHHHH----------------------------------HHH--------HHHHHHHHHHHHHHH-------EEE-------------EEEE--------------HHHHHHHHHHHHHHHHHHHH----------------HHH--------------------HHHHHHHHHHH--------------------- PAPD1_2 sable --------------------------------------------------------HHHHHHH-------------HHHH-------------------------------------------HHHHHHHHHHHHHHH----------HHHHHHH------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHH----EEEE-------HHHHHHHHH-------EEEE----EEEEEE---HHHHHHHHH--------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH---EEEEEEE--E---------EEEEEE----------HHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHH--EEEEEEEE-----EEEEEEE----EEEEEEE---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHHH----------------------------------------------HHHHHHHHHHHHHH----EEEEEE-------------------------------HHHHHHHHHHHHHHHHHHHHH---------------------------------------------------------------------- PAPD1_2 proteus -EEEE----------EEE----EE------------------------------------H-EEEE----HHHHHHH---------EEE--------HHHHHH-------EEEE----------------HHHHHHHHHH-------------EEEH---------HHH--------------HHH--------HHHHHHHHH---EEEEE------HHHHHHHHHH----------HH---EEEEEE--HHHHHHH-----------H--------HHHH---------------------HHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHH----EEEEEE-------------EEEEE----------------HHHH-------HHHHHHHHHHHHHHHHHH-----EEEEEEEE-E--EEEEE-----EEEEEE---HHHHHHHHHHHHHHH----HHHHHHHHHHHHHH-------------HHHHHHHHHHHHH---------HHHH---------EEE----------HHH---------HHHHHHHHHHHHHH------EEEEE------------EEEE--------------HHHHHHHHHHHHHHHHHHH----------------HEH--------------------HHHHHHHHHHHH--------------EEEE--- PAPD1_2 sspro4 ----------------------------------------------------------------HHHH----------------------------------------------------------HHHHHHHH----------------------------------------------------------HHHHHHHHHH-----EEE-------HHHHHHHHHHH------EE------EEEEE-----HHHHHH------------------------------HHH------------HHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH----EEEEE-------------EEEEEE--------------HHHHHHH-------HHHHHHHHHHHHHHHHHH----EEEEEE------EEEEEE-----EEEEEE---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------------HHHHHHHHHHHHHH--------HHHH---------EEE----------HHH---------HHHHHHHHHHHHHH------EEE--------------EEEE--------------HHHHHHHHHHHHHHHHHHHHH--------------HHHHH--------HHHHHH------HHHHHHHHHHH--------------EE---- PAPD1_2 psspred HHHHHHH--------------------HH-------------------------------HHHH----------HH---------------------HHHHHHHH------------------------HH--HHHHHHHHHHH--------HHHHHH--------------H-HHHHHH------------HHHHHHHHHHHH---EE--------HHHHHHHHHHH----EEEEE----EEEEEEE--HHHHHHHHH-----------------------H---HHHHHHHH--------HHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH---EEEEEE-----------EE-EEEEE---------------HHHHHHH-----HHHHHHHHHHHHHHHHHHH-------EE------EEEEEEE----EEEEEEEE---HHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHH------------HHHHHHHHHHHHHHH-------HHHHHHHH-----EEE-------H--HHH-------HHHHHHHHHHHHHHHH------EEEE----EE-------EEE---------------HHHHHHHHHHHHHHHHHHHHH-H-----------HHHHHH---------HHHHHH-----HHHHHHHHHHHH-------------E----- PAPD1_2 spineX -----------------------------------------------------------------------------------------------------------------------------------------H-------------------------------------------------------------------EEEEE----------EEEEE-----------------EEEEE-----------------------------------------------------------HH---HHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHH----EEEEE----------------EEEE----------EEE--EEEEEEEE--------HHHHHHHHHHHHH------EEEEEE------EEEEEE-----EEEEEE----HHHHHHHHHHHHHH-HHHHHHHHHHHHHHHH-----------E-HHHHHHHHHHHHH----------------------EEE---EEEE-------------HHHHHHHHHHHHHH--------EEEEE---EE-------EEEE--------------HHHHHHHHHHHHHHHHHH----------------EEEEEE--------------------------------------------------- PAPD1_2 raptorxss --EHHH---------E------------HHH------------------------HH----HHHHHHH------HHHHHHH--HHHH-----------H---------------------HHHH-----HHHHHHHHHHH-----HHHH-HHHHHHH--------------HHH---HH-----HHH-HH-HHHHHHHHHHH-----HHE-------HHHHHHHHHHH--EEEEEEE----EEEEEEE--HHHHHHHH----------------E-------------HH-HH--------HHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHH----EEEEEE-EE----------EEEEE-----------------HHH-------HHHHHHHHHHHHHHHHHH-----EEEEEE-------EEEEE----EEEEEEE--HHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHH------------HHHHHHHHHHHHHH---------HHHH---------------E------HHHH--------HHHHHHHHHHHHHH--H----EE------E-------EEEE--------------HHHHHHHHHHHHHHHHHHH---H-----------HHHHHH---------HHHHH-------HHHHHHHHHH------------E--E---- PAPD1_2 SPARROW --HHH-------------------------------------------------HHHH---H------------------------------------------------------------------------------------------------------------------------------------H-------H------------------HHHHH----------------EEEEE------HHHHH---------------------------------------------HHHHHHHHHH---HHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH----EEEEE---------------EEEE----------------------------HHHHHHHHHHHHHHHHH-------EEEE-------EEEEE-----EEEEE----HHHHHHHHHHHHHHH---HHHHHHHHHHHHHH-------------HHHHHHHHHHHHHH---------HH-----------E-----------HHH--------HHHHHHHHHHHHH--------EEE-----EE-------EEEE-----H--------HHHHHHHHHHHHHHHHHHHH---------------HHHH---------HH---------------HHH----------------------- PAPD1_2 *SPARROW HHHHHHH-----E----------E----H--------------------------HHHHHHHHH------------------------------------------------HHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------------------------HHHHHHHHHHHHHHHHHEEEEEE-----HHHHHHHHHHH--EEEEEE------EEEEEEE-HHHHHHHHHH------------------EEEE-------------------HHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHH----EEEEE---------------EEEEE---------------HHHH-------HHH-HHHHHHHHHHHHHHH----HEEEEEE------EEEE------EEEEEEE-EEEEEHHHHHHHHHHH---HHHHHHHHHHHHHHHEE-------EEEEEEEEEEEEEEHHH--------HHHHHHHHHH---EEEE---EEEE--HHHEE----HHHHHHHHHHHHHHEEEE----EEEEE-----E------EEEEE--------------HHHHHHHHHHHHHHHHHH------------------HHEE------------------HHHHHHHHHHHHH-------------HHHHHHH PAPD1_2 HMMSTR --HHHHH----------------E--HHHH---------------HHH-----HHHHHHHHHHHH--------------------------------HHHHHH------------------HHH----HHHHHHHHHHHHHHHH----------EEEE-------------------HH-----EE-------HHHHHHHHH----EEEEEE-----HHHHHHHHHH------EEE------HHHHH---HHHHHHHH----------------------HHH-------------------HHHHHHHHHHHH-HHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHH----EEEEEEEEEE---------EEEEEE--------HHH---HHHHHHHH-----HHHHHHHHHHHHHHHHHH-----E--EE-------EEEEEE----EEEEEEE----HHHHHHHHHHHHH---HHHHHHHHHHHHHHH-------------HHHHHHHHHHHHHH------------HHH------EEE---------------------HHHHHHHHHHHHHH-------EEEEE------------EEEE--------------HHHHHHHHHHHHHHHHHHHHHH------------EEEEE-----------HHHH-----HHHHHHHHHH------HHHHH-----EE---- PAPD1_2 spine HHHHHH--------------------------------------------------------------------------------------------HHHHH------EEEE-------EEE------HHHHHHHHHHHHHHH----------------------------------------------HHHHHHHHHHHHH---EEEEE------HHHHHHHHHH--------EE----HHHHHHHH----------------------------EE-EE---------EEE---------HHHHHHHHHHHHHHHHHHHHHHHHHH------EEEEEHHHHHHHHHH--------------------------------------------EEEEEE--------HHHHHHHHHHHHHH---------HHHHH-----EEEE-------EEEE-----EEE---HHHHHH---------EEEEHHHHH----------------------EEEEE----------HHHHHHHHH----EEE-----EEEE-----------HHHHHHHHHHHHHH----------EE--------------EE---------------HHHHHHHHHHHHHHHHHHH----------------EEEEE----------------HHHHHHHHHHHHHH-------EE------EEEEE- PAPD1_2 nnssp --HHHHH---------------EEEE-------------------------------------------------------------------------EEEEEE---------------------HHHHHHHHHHHHHHHHH-------HHHHHHHHH------------HHHHHHHHHH--------HHHHHHHHHHHHHHHHHHHHHH-HHH--HHHHHHHHHHH-------------EEEEEEE---------------HHHHHHHHHHHHHHHHHH---------------------HHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH---EEEE---------------HHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHH-------HHHHH-----EEEE---------------EEEEE-HHHHHHHHHHHHHHHHHHHHHHHHHHH----------------HHHHHHHHH----------HHHHHHHHHH---EEEE--EEEEEEE---------HHHHHHHHHHHHHH-------------------------EEEEE--------------HHHHHHHHHHHHHHHHHHHH---------------EEEEEE------------------HHHHHHHHHHH--------------------- PAPD1_2 pssfinder HHHHHHH-------------------------------------------------------EEE---------------------------------HHHHH------EEEEE-----EEEE----HHHHHHHHHHHHHHHHH---------HHH--------------------------------HHHH--HHHHHHHHHH--EEEEE--------HHHHHHHH----------------HHHHHH-----------------HHHHH-HHH---EEEEEE---EEEEEEEE--------HHHHHHH---HHHHHHHHHHHHHHH--------EEEEHHHHHHHHHH-------------------------EEE-HHHHH-------------EEEEEE--------HHHHHHHHHH----------HHHHH-----EEEHHH-----EEEEEE---EEEE---HHHEEE-----EEEEEEEEEHHH-------------------HHHHEEE-------------HHHHHHHH---EEE------HHHHH--------HHHHHHHHHHHHHH----------EEEE------------------------------HHHHHHHHHHHHHHHHHHH----------------EEEEE----------------HHHHHHHHHHHHHH--------------EEEEEEE PAPD1_2 sspal ----------------------EEEE--------------------------------------------------------------------HHHHHHHHH------EEEEEEE---------HHHHHHHHHHHHHHHHH------HHHHHHHHHHH-------------HHHHHHHHH--HHHHHHHHHH-HHHHHHHHHHHEEEEEEE----HHHHHHHHHHH--------------EEEEEEEE----------------------------EEEEEEE--------------HHHHHHHHHHHH---HHHHHHHHHHHHH-HHHHHHHHHHEEEEEHHHHHHHHH---EEEE--------------HHHHHHHHH-------------EEEEEEEEEE--HHHHHHHHHHHHHHHHH-------HHHHHHHHH--EEEEEEE---EEEEEEE---EEEE--HHHHHHHHHHHHEEEEEEEE------EEEEEEE-------EEEEEEEEEEE----------HHHHHHHHHHH--EEEE---EEEEE-----------HHHHHHHHHHHHH----------HHHHHHHHH-------EEEE----------------HHHHHHHHHHHHHHHHH----------------EEEEEEE----------HHHHHHHHHHHHHHHHH---------------------- PAPD1_2 ssp ---HH----------------------------------------------------------HH----------------------------------HHH---------------------------HHHHHHHHHHHHHHH----------HE--------------------------------------HHHHHHHH----EE---------HHHHHHHHHH------EEEE---EEEEEEEEE------------------------------------------------------HHHHHHHHH---HHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHH-----EEEEEE------------EEEEEEE---------------------------HHHHHHHHHHHHHHHH------EEEEEE-----EEEEEEE----EEEEEEEE-----HHHHHHHHHHHH---HHHHHHHHHHHHHHH------------HHHHHHHHHHHHHH----------------------------------------------HHHHHHHHHHHHEEE----EEEEEE--------------EE--------------HHHHHHHHHHHHHHHHHHHHHH-------------HH-----------------------HHHHH-----------------HH------- PAPD1_2 sspred ------------------------------------------------------------------------------------------------------------------------------HHHHHH--------------------------------------------------------------HHHHHH--------------HHHHHHHHH-------------------EEEEE---HHHHHHHH--------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHH----EEEEE--------------EEEEE-----------------H----------HHHHHHHHHHHHHHHHH-------EEEE-------EEEEE----EEEEEEE----HHHHHHHHHHHHHH---HHHHHHHHHHHHHH-------------HHHHHHHHHHHHHH-----------------------E-------------------HHHHHHHHHHHHHHHHH------EEE--------------EEEE--------------HHHHHHHHHHHHHHHHHHHHH--------------------------------------HHHHHHHHHH---------------------- PAPD1_2 netsurfp ---HHH--------------------HHHH-------------------------------HHH-----------E--------EEE----------------------------HH-----------------------EEEE--------EE---H----------------------------------H-HHHHHHHHHH----EE-------HHHHHHHHHH------EEEE----EEEEEEE-----HHHHHHHH----------EEEE----------------------------HHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH----EEEEE--EE--------EEEEEEE----------------------------HHHHHHHHHHHHHHHHH-----EEEEEE------EEEEE-----EEEEEEE----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------------HHHHEEEEEEHHHH--------HHHHH-H------EEE----------HHHH--------HHHHHHHHHHHHHHHHH---EEEE----EE------EEEEE--------------HHHHHHHHHHHHHHHHHHHHH--------------HHHHH------------HH--------HHHHHHHHH-------------------- PAPD1_2 soprano --HHHH---------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHH--------------------------------------------------HHHHHHHHHHH---EEEE-------HHHHHHHHHH------EEE-----EEEEEEE----HHHHHH--------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH----EEEEE--------------EEEEE-----------------HHH--------HHHHHHHHHHHHHHHHH-----EEEEEE------EEEEEE----EEEEEEE---HHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHH-------------HHHHHHHHHHHHHH--------HHHH---------EEE----------H---------HHHHHHHHHHHHHHH-------EEEE-------------EEEE--------------HHHHHHHHHHHHHHHHHHHH---------------HHH---------------------HHHHHHHHHHH--------------------- PAPD1_2 consensus MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQRRILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVAPRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPEDLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNILGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWYVFRLY PAPOLA_2 sequence --------------------------------HHHHHHHHHHHHHH--------HHHHHHHHHHHHHHHHHHHHHHHHHHHH-------------EEEE---EE---------EEEEEE------HHHHHHHHHHHH--------EEE-------EEEEEE--EEEEEEEEE---------------HH-----HHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHHH-----HHHHHHHHHHHHH-------- PAPOLA_2 psipred --------------------------------HHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHH---EEEEEE-EEEEEE-------EEEE------HHHHHHHHHHHHHH---------------EEEEEEE---EEHHHHHHHHH-----------HHHHH---HHHHHHH----HHHHHHHH---HHHHHHHHHHHHHHHHH---HHHHH--HHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHH------- PAPOLA_2 prof --------------------------------HHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHH----EEEE--EEEEE------EEEEEE--------HHHHHHHHHH-------E--------EEEEEEE-----EEEEE---------------HHHHH-------EEE----HHHHHHHHH--------HHHHHHHHHHH-------EE-----HHHHHHHHHHHHH------HHHHHHHHHHH--------- PAPOLA_2 jnet --------------------------------HHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHH-------------EEEEE--------------EEEEEE-----HHHHHHHHHHHHH-----EEEEEE-----EEEEEEE---EEEEEEEE----------------HHH---HHHHHH---HHHHHHHHHHH----HHHHHHHHHHHHHHH------------HHHHHHHHHHHHHH-----HHHHHHHHHHHHHH------- PAPOLA_2 sable -----------------------------------HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHH----EEEEE-HHHH--EEE--EEEEEEEEE----HHHHH-HHHHHHHH------EEEE-----EEEEEE---EEEEEEEEEEE--EEE-------HHHH------HHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHH-EEE----EEEHHHHHHHHHHHHHH-----HHHHHHHHHHHHH-------- PAPOLA_2 proteus -----------------H--------------HHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHH---EEEE----------------EEEE------HHHHHHHHHHHHHH-HHHHH---------EEEEEEE---EEEEHHHH---------------HHHH---HHHHHH----HHHHHHHHH---HHHHHHHHHHHHHHHHH-------------HHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHH-- PAPOLA_2 sspro4 --------------------------------HHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHH----EEEEEE-------------EEEEEEE-----HHHHHHHHHHHHHH----EEEEEE----EEEEEEEEE--EEEEEEEE---------------HHH----HHHHHH--HHHHHHHHHHHH---HHHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHHH----HHHHHHHHHHHHHH------- PAPOLA_2 psspred ---EE---------------------------HHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----------EEEEE---E------------EEEEE-----HHHHHHHHHHHHHH------EEEE--EEEEEEEEEE----EEEEEEE--------------HHHHHH--HHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHH--HHHHH----HHHHHHHHHHHHHHH----HHHHHHHHHHHHHH---H--- PAPOLA_2 spineX --------------------------------HHHHHHHHHHHHHH--------HHHHHHHHHHHHHHH-----EEEEEEEE-------EE----EEEEE---------------EEEEE-----HHHHHHHHHHHHH------EEEEE-EEEEEEEEEEE---EEEEEEEEEE--------------------HHHHHH--HHHHHHHHHHH---HHHHHHHHHHHHHHHHH-------E----HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHH- PAPOLA_2 raptorxss --------------------------------HHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHH----HH------EEEEE----H--EE-----EEEEEEE-----HHHHHHHHHHHHH-----EEEEEE------EEEEEE--E-EEEEE----------------HHHH----HH-HHHH-HHHHHHHHHHH-----HHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHHH-----HHHHHHHHHHHHHH---HH-- PAPOLA_2 SPARROW --------------------------------HHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHHH------------EEEEE------E-------EEEEE------HHHHHHHHHHHHHH-----EEEEE----EEEEEEEE---EEEEEE---------------------------HHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHH------------HHHHHHHHHHHHHH-----HHHHHHHHHHHHHH------- PAPOLA_2 *SPARROW -----------------HH-------------HHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHH--EEEEE-EEEEEE--------EEEEE-EEEEHHHHHHHHHHHHHH-HHHHHHHH---H----EEEEE----EEEEEHHHE------------HHHHHH--HHHHHHE------HHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHH-----HHHHHHHHHHHHHH-----EE PAPOLA_2 HMMSTR --------------------------------HHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHH-E-EEEEEHHHHH--------EEEEEEE-----HHHH--HHHHHHH----EEEEEEE------EEEEEE--EEEEEEEEE-----E--------HHHH----HHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHH---E-HHH--E-HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHH--- PAPOLA_2 porter -----------------------------------EEHHHHHHHHH--------HHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHH-----EEEE---EEEE--------EEEE----------------HHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHH----------HHHHHH-HHHHH-------HHHHHHH------HHHHHHHHHHHHHH---HHHHH-------HHHHHHHHHH----HHHHHHHHHHEEEE--EEEEEEE PAPOLA_2 nnssp --------------------------------HHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHH-----EEEE-HHHHH--------EEEEEEE-----HHHH--HHHHHHH----EEEEEEE------EEEEEE--EEEEEEEEE--------------HHH-----HHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHH------------HHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHH-- PAPOLA_2 pssfinder -----------------------------------HHHHHHHHHH-------HHHHHHHHHHHHHH-HHHHHHHHHHHHHH-------HHHH---EEEEE------EE-------EEEE---------HHHHH--HHHHHHHHHHHHHHHHHH-HHHHH------HHHHHHHHHHHH---------HHHHHHH-HHHHH------HHHHHHH-------HHHHHHHHHHHHHH------EEEE-----HHHHHHHHHHH------HHHHHHHHHH-----EEEEE PAPOLA_2 sspal -----------------------------------EEEEHHHHHHHH-EEEHHHHHHHHH---HHHHHHHHHHHHHHHH-----------------EEEE--EEEEEEE---------------HHHHHHHHHHHHHH--HHHHHHHHHHHHH--EEEEEEE---HHHHHHHHH---HHHHHHHHHHHHHH---EEEEEEE----HHHHHHHHH-----HHHHHHHHHHHHHHH------------HHHHHHHHHEEEEE------EEEEEEEEEE--------- PAPOLA_2 ssp ----------------------------------HHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHH---EEEEEE-EE-----------EEEEE-----HHHHHHHHHHHHHH-----EEEEE-----EEEEEEEE-EEEEEEEEEEEH-------------HHHHHHHHHHH-----HHHHHHHHH------HHHHHHHHHHHHHH-------EE-HHHHHHHHHHHHHHEEE-----HHHHHHHHHHHHEEEEE--- PAPOLA_2 sspred --------------------------------HHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHH------------EEEEEE-HH---------EEEEEE-------HHHHHHHHHHHHH-------EEE---EEEEEEEEE------EEEEE--------------HHHHH---HHHHHHH-HHHHHHHHHHHH--HHHHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHHH-----HHHHHHHHHHHHH------- PAPOLA_2 soprano --------------------------------HHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHH-----EEEEE--------------EEEEEE-----HHHHHHHHHHHHHH-----EEEEE-----EEEEEEE---EEEEEEEE--------------HHHHH---HHHHHHH-HHHHHHHHHHH----HHHHHHHHHHHHHHHH------------HHHHHHHHHHHHHH-----HHHHHHHHHHHHHH------- PAPOLA_2 consensus MSDSEKLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPADKNKGKYGQFSGLNPGGRPITPPRNSAKAKK PP-1A_1 sequence --------HHHHHHHHHH-------------HHHHHHHHHHHHHHHHH---EEEE---EEEE------HHHHHHHHHH---------EE----------HHHHHHHHHHHHH-----EEEE--------------HHHHHHHH--HHHHHHHHHH-----HHEEE---EEEEE---------HHHHH--------------HHH--------------------EE--HHHHHHHHHH----EEEEE-------HH------EEEEE------------EEEEEE-----EEEEEE---------------------------------- PP-1A_1 psipred --------HHHHHHHHHHHH-------EE--HHHHHHHHHHHHHHHH----EEE-----EEEE----HHHHHHHHHHH--------EEEE--EE-----HHHHHHHHHHHH------EEEEE----HHHHHHHH--HHHHHHHH-HHHHHHHHHHH----EEEEE---EEEE----------HHHHHHH-----------HHH-------------------EEEEE-HHHHHHHHHH-----EEHHHHHHHHHHHHHH--EEEEEEE------------EEEEE-HHHEEEEEEE---------------------------------- PP-1A_1 prof ------HHHHHHHHHHHHH------------HHHHHHHHHHHHHHHHH----EE----EEE------HHHHHHHHHHH--------EEEE---------HHHHHHHHHHHHHH----EEEEE----------EEE-HHHHHHHHHHHHHHHHHHHHHH--HHHHHH--EEEE-------HHHHHHHH--------------EEEE-----------------EEEEE--HHHHHHHH----EEEHHHHHHHHHHHHHH---EEEEEEE----------HHHHHHHHHHHHHHHHH----------------------------------- PP-1A_1 jnet --------HHHHHHHHHHH------------HHHHHHHHHHHHHHHH----EEEE---EEEEE-----HHHHHHHHHH--------EEEE---------HHHHHHHHHHHHH-----EEEE-----HHHHHHH---HHH------HHHHHHHHHHHH---HHHH----EEEE----------HHHHHH------------HE-E------------------EEEE--HHHHHHHHHH----EEEEEHHHHH--HHHH----EEEEE------------EEEEEE-----EEEEEE---------------------------------- PP-1A_1 sable ---HH---HHHHHHHHHH-------------HHHHHHHHHHHHHHHHH---EEEE---EEEE-E----HHHHHHHHHHH-------EEE----------HHHHHHHHHHHHHH----EEE-------HHHHHHH-HHHHHHHH--HHHHHHHHHHH-----EEEE---EEEE----------HHHHHH-----------HHHHHHH-EE------EEE------EEE-HHHHHHHHHHH---EEEE--------EEEE----EEEEE------------EEEEEE-----EEEEEE----H----------------------------- PP-1A_1 sspro4 --------HHHHHHHHHHHH-----------HHHHHHHHHHHHHHHHH---EEEE---EEEEE-----HHHHHHHHHH-------EEEEE---------HHHHHHHHHHHHHH---EEEEEE------HHHHHH-HHHHHHHHH-HHHHHHHHHHHHH--EEEEE---EEEEE---------HHHHHH-----------HHHHHH------------------EEEE-HHHHHHHHHHH---EEEEE-----H-HEEEE--EEEEEE-----------EEEEEEE-----EEEEEE---------------------------------- PP-1A_1 psspred --------HHHHHHHHHHHH-----------HHHHHHHHHHHHHHHHH-----E----EEEE-----HHHHHHHHHHHH--------------------HHHHHHHHHHHHHH----EEE-------HHHHHHH-HHHHHHHHH-HHHHHHHHHHHHHHHHHHHHH-EEEEE----------HHHHHH------------H---------------------------HHHHHHHHHHH---EEEEHHHHHHH--EE----EEEEEEE-----------EEEEEEE---EEEEEE----------------------------------- PP-1A_1 spineX --------HHHHHHHHHH---------EE--HHHHHHHHHHHHHHHH----EEEE----EEE------HHHHHHHHHH----------------------HHHHHHHHHHH-------EE-----------EE---HHHHHH---HHHHHHHHHHHHH--HH-E---EEEE-----------HHHHHH----------------E------------------EEEE-HHHHHHHHHH---HHHHHHHHHHHHHHHHH----EEEEEE-----------EEEEEE----EEEEEEEE--------------------------------- PP-1A_1 raptorxss --------HHHHHHHHHH-------------HHHHHHHHHHHHHHHH----EEEE---EEEE------HHHHHHHHHH--------EEE---EE-----HHHHHHHHHHHHHH----EEEEE-----HHH-EEEE-HHHHHH---HHHHHHHHHHH---EEEEEE--EEEEE----------HHHH--------------HH-E-------------E------EE--HHHHHHHHHHH---EEEE---E-HHHHHEE---EEEEEEE----------EEEEEEE-----EEEEEE---------------------------------- PP-1A_1 SPARROW --------HHHHHHHHHH-------------HHHHHHHHHHHHHHHH------EE----EEHHH--H-HHHHHHHHH---------E-E-HHH------HHHHHHHHHHHHHH-----EEE-H----HHHH-----HHHHHHHH-HHHHHHHHHHHH----HHHH---EEEE----------HHHHHH-----------HH---------------------------HHHHHHHHHH----EEEE--HHHHHHHHHHH---EEEEEE----------EEEEEEE-----EEEEEEE---HH---------------------------- PP-1A_1 *SPARROW -----HHHHHHHHHHHHHHH------EEE--HHHHHHHHHHHHHHHHH---HHHH---EEEEE-E----HHHHHHHHH--------EEEEE-EE-----HHHHHHHHHHHHHH---EEEEEE--------EEE----HHHHHH--HHHHHHHHHHE----HHHHH-HEEEEEE----HHHHHHHHHHHHHH---------HHHHHHH---H------------EEEEEHHHHHHHHHHH---EEEEHHEEEE---EEEEHH-EEEEEE------E------EEEE-HHHEEEEEEE----HH---------------------------- PP-1A_1 HMMSTR --------HHHHHHHHH--------------HHHHHHHHHHHHHHHHH---EEEE---EEEE-E----HHHHHHHHHHH-------EEE----------HHHHHHHHHHHHHH----EEE-------HHHHHHH-HHHHHHHH--HHHHHHHHHHH-----EEEE---EEEE----------HHHHH------------HHHHHHH-EE------EEE------EEE-HHHHHHHHHHH---EEEE--------EEEE----EEEEE----HHH-----EEEEEE-----EEEEEE----------EEE--------------------- PP-1A_1 porter --------HHHHHHHHHHH--------EEE--------------------------------------HHHHHHHHH----------EE-----------HHHHHHHHH--------EEEE--------HHHHH-----------HHHHHHH----------------EEE--------HHHHHHHHHHH---------------------------------EEE--HHHHHHHHHH----HHHHHHHHHHH---------EEEE---------------------------------------------------------------- PP-1A_1 nnssp --------HHHHHHHHHHH------------HHHHHHHHHHHHHHHHH---EEEE---EEEE------HHHHHHHHHHH-------EEE----------HHHHHHHHHHHHHH----EEEE------HHHHHHH-HHHHHHHH--HHHHHHHHHHHHH---EEEE---EEEE----------HHHHHH-----------HHHHHHH-EE------EEE------EEE-HHHHHHHHHHH---EEEE--------EEEE----EEEE-------------EEEEEE-----EEEEEE---------------------------------- PP-1A_1 pssfinder ---------HHHHHHHHHH-------EE----HHHHHHHHH--HHH--HHHHHHHHH-----------HHHHHHHHHH--------EEEE---------HHHHHHHHHHHH------EEEE--------HHHHH-HHHHHHHHH-HHHHHHH--------EEEEE----EEEE------HHHHHHHHHHH--------------------------------------HHHHHHHHHH---HHHHHHHHHHHHHHHHH----EEEEE-------------------HHHHHHHHHH-----------------------------HHHHH PP-1A_1 sspal -------HHHHHHHHHHH---------EEEE----------------HHHHHHHHHH-EEEE------HHHHHHHHH-----------------HHHHHHHHEEEEEEEEEEEE----------------------HHHHHHHEEEEEEE----------HHHHHHHHH----------HHHHHHHHHHHH--------EEEEEEE----------------EEEEE-HHHHHHHHH----HHHHHHHHHHHH-HHHHHHHHHEEEE-----------------HHHHHHHHHHHHH--------------------------------- PP-1A_1 ssp --------HHHHHHHHHHH------------HHHHHHHHHHHHHHHHH----EEE--EEEEEE-----HHHHHHHHHHH------EEEEE-H--------HHHHHHHHHHHHHE--EEEEE--------HHH----HHHHH----HHHHHHHHHHHHH-----EE--EEEEEE------------HHH----------------------------------------HHHHHHHHHHH--EEEEE-----HH--EEE----EEEEE----HH-----HEEEEEE-----EEEEEE---------------------------------- PP-1A_1 sspred --------HHHHHHHHHHH------------HHHHHHHHHHHHHHHHH---EEEE---EEEEE-----HHHHHHHHHH--------EEEE---E-----EEEEEEEEEEE-HH----EEEEE-----H-H--HH-HHHHHHHH--HHHHHHHHHHHHH--EEEEE--EEEEE----------HHHHH-H-----------E--EE-------------------EE--HHHHHHHHHH----EEEEEEEEE----EEEE--EEEEEEE-----------EEEEEE-----EEEEEE----HH---------------------------- PP-1A_1 soprano --------HHHHHHHHHHH------------HHHHHHHHHHHHHHHHH---EEEE---EEEE------HHHHHHHHHH--------EEE----------HHHHHHHHHHHHHH----EEEE------HHHHHHH--HHHHHHH--HHHHHHHHHHHH---H-EEE---EEEE----------HHHHHH------------HH----------------------EEE-HHHHHHHHHH----EEEEHHHHHHH-HHEE----EEEEE------------EEEEEE-----EEEEEE---------------------------------- PP-1A_1 consensus MAVPGVGLLTRLNLCARRRTRVQRPIVRLLSCPGTVAKDLRRDEQPSGSVETGFEDKIPKRRFSEMQNERREQAQRTVLIHCPEKISENKFLKYLSQFGPINNHFFYESFGLYAVVEFCQKESIGSLQNGTHTPSTAMETAIPFRSRFFNLKLKNQTSERSRVRSSNQLPRSNKQLFELLCYAESIDDQLNTLLKEFQLTEENTKLRYLTCSLIEDMAAAYFPDCIVRPFGSSVNTFGKLGCDLDMFLDLDETRNLSAHKISGNFLMEFQVKNVPSERIATQKILSVLGECLDHFGPGCVGVQKILNARCPLVRFSHQASGFQCDLTTNNRIALTSSELLYIYGALDSRVRALVFSVRCWARAHSLTSSIPGAWITNFSLTMMVIFFLQRRSPPILPTLDSLKTLADAEDKCVIEGNNCTFVRDLSRIKPSQNTETLELLLKEFFEYFGNFAFDKNSINIRQGREQNKPDSSPLYIQNPFETSLNISKNVSQSQLQKFVDLARESAWILQQEDTDRPSISSNRPWGLVSLLLPSAPNRKSFTKKKSNKFAIETVKNLLESLKGNRTENFTKTSGKRTISTQT PAPD1_1 sequence ------------HH------------------------------------------------HHHHHHHHHHH--EEEEEE------HHHHHHHHH----------------EEEEE---HHHHHHHH------------------------------HHHH-----------HHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH----EEEEE---------------EEEE---------------HHHHHHH----HHHHHHHHHHHHHHHHHHH-------EEEE-----EEEEEEE----EEEEEEEE--HHHHHHHHHHHHHH---HHHHHHHHHHHHHHH-------------HHHHHHHHHHHHHH----------------------------------------------HHHHHHHHHHHHH-------EEEEE------------EEEE--------------HHHHHHHHHHHHHHHHHHH------------------------------HHH----HHHHHHHHHHHHHH--------------------- PAPD1_1 psipred ------EEEE---EEE----------------------------------------------HHHHHHHHHHH---EEEEEE-----HHHHHHHHHH---EEEEEEE----EEEEEEE-----HHHHH--------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH----EEEE----------------EEEEE------------------------------HHHHHHHHHHHHHHH----EEEEEEE-----EEEEE------EEE-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHHHH--------HHH----------EEE----------HHH-------HHHHHHHHHHHHHHHEE-----EEEEE------------EEEE--------------HHHHHHHHHHHHHHHHHHHH---------------HHHH-------------------------HHH------------------------ PAPD1_1 prof ----------EEEEEE---------------------------------------------HHHHHHHHHHH---EEEEEE------HHHHHHHHH------EEEEE----EEEEEE---HHHHHHHHHH----------EEEE-----------------------------HHHHHHH-----HHHHHHHHHH--------HHHHHHHHHHHHHHHHHH----EEE---EEE---------EEEEEE-------------------------------HHHHHHHHHHHHHH-------EEE-----EEEEEEE-----EEEEEE---HHHHHHHHHHHHHHHH----HHHHHHHHHHHHHH-------------HHHHHHHHHH------------------------EEEE--------------------HHHHHHHHHHHHH---------EE-------------EEEEE--------------HHHHHHHHHHHHHHHHHHHH-------------------E--------------------------------------------EEE---- PAPD1_1 jnet -EE-----------------------------------------------------------HHHHHHHHHHH---EEEEE------HHHHHHHHHH----EEEEE------EEEEEE----HHHHHH----------------------------------------------HHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHH----EEEEE--------------EEEEE------------------------------HHHHHHHHHHHHHHH-----EEEEEE------EEEEE-----EEEEEEE---HHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHH-------------HHHHHHHHHHHHHH---------HH-----------------E-----HHH---------HHHHHHHHHHHHHH-------EE-------------EEEEE--------------HHHHHHHHHHHHHHHHHHHH---------------HHHH---------------------HHHHHHHHH---------------------- PAPD1_1 sable --------------------------------------------------------------HHHHHHHHHH----EEEEE------HHHHHHHHHH------EEE-------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH---EEEEEEEE-----------EEEEEE-----------HHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHH----EEEEEEE------EEEEEE----EEEEEEEE--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------------HHHHHHHHHHHHH-----------------------------------------------HHHHHHHHHHHHHH--------E---------------EEE--------------HHHHHHHHHHHHHHHHHHHH----------------------------------------------------------------------- PAPD1_1 proteus ------E------HHHHH----------------------------------EE-----HHHHHHHHHHHHHHH--EEEEE----HHHHHHHHHHH--------E-------EEEEEE---HHHHHH--------------------EEE----------------------HHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHH----EEEEEE--------------EEEE---------------HHHH------------HHHHHHHHHHHHHH-----EEEEEEEE----EEEEE------EEEEE----HHHHHHHHHHHHHH----HHHHHHHHHHHHHH-------------HHHHHHHHHHHHH---------HHHH---------EEE----------HHH---------HHHHHHHHHHHHHH------EEEEE------------EEEE--------------HHHHHHHHHHHHHHHHHHH----------------HHHH-------------------HHHHHHHHHHHH--------------EEEE--- PAPD1_1 sspro4 --------------------------------------------------------------HHHHHHHHHHHH--EEEEE------HHHHHHHHHH-------EE----------------HHHHHH-----------------------------HHHHH----------HHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH----EEEEE-------------EEEEEEE-------------HHHHHHHH-----HHHHHHHHHHHHHHHHHHH----EEEEEEE-----EEEEEE---EEEEEEEE----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------------HHHHHHHHHHHHHH--------HHHHHH-------EEE----------HHH---------HHHHHHHHHHHHHH------EEE--------------EEEE--------------HHHHHHHHHHHHHHHHHHHH---------------HHHHH----------HHHH-------HHHHHHHHH--------------------- PAPD1_1 psspred ------------------------HHHHHH-----HHHHH----------------------HHHHHHHHHHHH--EEEEEE-----HHHHHHHHHHH----EEEEE----EEEEEEE--HHHHHHHHH---------------------------HHHHHHHH--------HHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH----EEEEE-----------EE-EEEEE--------H------HHHHHHHH---HHHHHHHHHHHHHHHHHHHH-------EEE-----EEEEEEE----EEEEEEEE--HHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHH------------HHHHHHHHHHHHHHH-------HHHHHHHH-----EE--------H--HHH---------HHHHHHHHHHHHHH------EEEE----E-------EEEEE--------------HHHHHHHHHHHHHHHHHHHH---------------HHHHH---------HHHHHH----HHHHHHHHHHHHH------------------- PAPD1_1 spineX --------E-------------------E---------------------------------HHHHHHHHHHH----EEEE------HHHHHHHHH--------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHH-----EEEE---EE-----------EEEE---------EEEE-EEEEEEEEEE----HHHHHHHHHHHHHHHH-----EEEEEEE-------EEEE-----EEEE-----HHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHH-------------HHHHHHHHHHHHHH---------------------EEEEEEEEEEE------------HHHHHHHHHHHHHH--------EEEEE---EE-------EEEE--------------HHHHHHHHHHHHHHHHHH----------------EEEEEE-------------------------HH------------------------ PAPD1_1 raptorxss ----------E-EE------------------------------------------------HHHHHHHHHHHHH-EEEEE------HHHHHHHHHH---EEEEEE-----EEEEEEE--HHHHHHHH-------------------------------HHH-H-------HHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHH----EEEEEE-EE---E----EEEEEEE----------------HHHHH-----HHHHHHHHHHHHHHHHHHH----EE-EEE--------EEEEE----EEEEEEE--HHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHH-------------HHHHHHHHHHHHHH--------HHH----------------E------HHH---------HHHHHHHHHHHHHH--H----EE-----EEE------EEEE--------------HHHHHHHHHHHHHHHHHHH---------------HHHHHH-----------HHH------HHHHHHHHHH----------------E---- PAPD1_1 SPARROW --------------------------------------------------------------HHHHHHHHHHHH--EEEEE------HHHHHHHHHHH-------E------EEEEE------HHHHH------------------------------------------------HHHHHHH---HHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH----EEEEE---HH--------EEEEEE-----------------HHH--------HHHHHHHHHHHHHHHHH------EEEEE-------EEEEE----EEEEEE----HHHHHHHHHHHHHHH----HHHHHHHHHHHHH-------------HHHHHHHHHHHHHH--------HHH----------EEE----------------------HHHHHHHHHHHHHH------EEE-----EE--------EE-----HHH-------HHHHHHHHHHHHHHHHHHH----------------HHHH----------HH-H-----------HHHHH---------------------- PAPD1_1 *SPARROW -EEE-H-HEHHHEEE-------------EE------EE---------------------HHHHHHHHHHHHHHHHHEEEEE------HHHHHHHHHHH-EEEEEEE------EEEEEEE-HHHHHHHHHH------------------EEEE-------------------HHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHH----EEEEE---------------EEEE--------------HHHHHHHHH----HHH-HHHHHHHHHHHHHHH----HEEEEEE------EEEE------EEEEEEE-EEEEEHHHHHHHHHHH---HHHHHHHHHHHHHHHEE-------EEEEEEEEEEEEEEHHH--------HHHHHHHHHH---EEEE---EEEE--HHHEE----HHHHHHHHHHHHHHEEE-----EEEEE-----E------EEEEE--------------HHHHHHHHHHHHHHHHHH-H----------------HHEE------------------HHHHHHHHHHHHHH------------HHHHHHH PAPD1_1 HMMSTR -------------HHHH--------HHHH------EEH----------EEEE-------HHHHHHHHHHHHHHH--EEEEE------HHHHHHHHHH------EEEE-----EEEEEE---HHHH----------------E------------------------------HHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHH-----EEEE--H----------EEEEEE-------------HHHHHHH--------HHHHHHHHHHHHHHHHH-----EEEEE--EEEE-EEEEEE------EEEEE---HHHHHHHHHHHHHHH--HHHHHHHHHHHHHHH-----------E-HHHHHHHHHHHHHH--H-H---HHHH--------------------------------HHHHHHHHHHHHHHH-------EEE---------------EEE--------------HHHHHHHHHHHHHHHHHHH----------------HHE---------------------HHHHHHHHHH---------------------- PAPD1_1 porter -------EEE---------------------------------------------HHHHHHHHHHHHHHHHHHHHHEEEEE------HHHHHHH------------------EEEEE----------------------------------------------------------------HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHH----EEEEE----EEE-------EEEEE----------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHH-----EEEE-------EEEEEE------HHHHHHHHH-------HHHHHHHHHHHHH---------------HHHHHHHHHHH--------HHHHH--------------------------------HHHHHHHHHHHHH---------EEEE------------EEEE-----------------HHHHHHHHHHHHHHHHHHHH-----------HHHHH-----------HHHHHH----HHHH---------------------------- PAPD1_1 cdm -------EEE-----------------------------------------------------HHHHHHHHHHHH-EEEEEE----------------------EEEE---EEEEEE-------HHHH---------------HHH-HHHHHHHHHHHH--------------HHHHHHH------HHHHHHHHHHH---HHHHHHHHHHHHHHHHHH-------EEEEEHHH----------EEEEEE-----------EE-----EE---------HHHHHHHHHHHHHHHH-----EEEEEE------EEEEEE----EEEEEE-----HHHHHHHHHHHH---HHHHHHHHHHHHHHHH-------------HHHHHHHHHHHHH-----------------------------------------------HHHHHHHHHHH-------------------HHHHHHHHHHH--------------HHHHHHHHHHHHHHHHHHHHHHH------------HHHH----------HHHHHH----HHHH---------------------------- PAPD1_1 fdm --------------------------------HHHHHHHHHHH--------------------HHHHHHHHHHHH-EEEEEE----------------------EEEE---EEEEEE-------HHHH---------------HHH-HHHHHHHHHHHH--------------HHHHHHH------HHHHHHHHHHH---HHHHHHHHHHHHHHHHHH-------EEEEEHHH----------EEEEEE-----------EE-----EE---------HHHHHHHHHHHHHHHH-----EEEEEE------EEEEEE----EEEEEE-----HHHHHHHHHHHH---HHHHHHHHHHHHHHHH-------------HHHHHHHHHHHHH-----------------------------------------------HHHHHHHHHHH-------------------HHHHHHHHHHH--------------HHHHHHHHHHHHHHHHHHHHHHH------------HHHH-------------------------------------HHHHH--EE------ PAPD1_1 gor ------EHHHHHHHHHHHHH-----HHHH------HHHH-----------------------HHHHHHHHHHHH--EEEEE------HHHHHHHHHH-----EEEE------EEEEE---HHHHHHHH---------------------------------H----------HHHHHHHHHHH---HHHHHHHHHH----HHHHHHHHHHHHHHHHHHHH----EEEEEEEEE-----------EEEEE--------HHH---HHHHHHHH-----HHHHHHHHHHHHHHHHHH-----E--EE----E--EEEEEE----EEEEEEE---HHHHHHHHHHHHHH--HHHHHHHHHHHHHHHH-------------HHHHHHHHHHHHHH--------HHHHHHH------EEE---------------------HHHHHHHHHHHHHH-------EEEEE-------------EE---------------HHHHHHHHHHHHHHHHHHHHHHH------------EEEE------------HHH----HHHHHHHHHHH------HH-HH-----EE---- PAPD1_1 spine ---------HHHHHHHHHH------HHHHH-----HHHHHHH-----------------HHHHHHHHHHHHHH---EEEEE------HHHHHHHHHH--------EE----HHHHHHH------------------HHHHH------EEEEEE--------EEE---------HHHHHHHHHHHHHHHHHHHHHHHHHH-------EEEEHHHHHHHHHH----------------------------------------------EEEEE------HHHHHHHHHHHHHHH---------HHHHH-----EEEE----------------EEE---HHHHHH-----HHHHHEEEHHHHHHH----------EEE-------EEE------------HHHHHHHHHH---EEE-----EEEE-----------HHHHHHHHHHHHHH--------------------------EE---------------HHHHHHHHHHHHHHHHHHH----------------EEEEE----------------HHHHHHHHHHHHHH----------------EEEE- PAPD1_1 nnssp -------HHHHHHHHHHH-------EEEEE-----------------------------HHHHHHHHHHHHHHHHHHHHHH-HHH--HHHHHHHHHHH-------------EEEEEEE---------------HHHHHHHHHHHHHHHHHH---------------------HHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH---EEEE---------------HHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHH-------HHHHH-----EEEE---------------EEEEE-HHHHHHHHHHHHHHHHHHHHHHHHHHH----------------HHHHHHHHH----------HHHHHHHHHH---EEEE--EEEEEEE---------HHHHHHHHHHHHHH-------------------------EEEEE--------------HHHHHHHHHHHHHHHHHHHH---------------EEEEEE------------------HHHHHHHHHHH--------------------- PAPD1_1 pssfinder -------HHHHHHHH----------HHHH------HHHHHH--------EE--------HHHHHHHHHHHHHHHHHEEEEE------HHHHHHHHHH--------------HHHHHHHH---------------------------EEEEEEE------EEEE---------HHHHHHHHHHH--HHHHHHHHHHHH------------HHHHHHHHHHH-----------------------HHHHHHHHHH-----------EEEEEEEEE-------HHHHHHHHHHHHHH-------HHHHHH----HHHH---------------EEEE-----EEEE-------EEEEEEE--HHHH----------EEE---HHHHHHHHH-------------HHHHHHH----EE-----EEE-----------HHHHHHHHHHHHHHH---------EEE-----------------------HHHH----HHHHHHHHHHHHHHHHHHH---------------EEEEEEE--------------HHHHHHHHHHHHHHH--------------EEEEEEE PAPD1_1 sspal -------HHHHHHHHHHHH--EEEEEEEEE-----HHHHHHHHHH--------HHHHHHHHHH-HHHHHHHHHHHEEEEEEE----HHHHHHHHHHH--------------EEEEEEEE----------------------------EEEEEEE--------------HHHHHHHHHHHH---HHHHHHHHHHHHH-HHHHHHHHHHEEEEEHHHHHHHHH---EEEE--------------HHHHHHHHH-------------EEEEEEEEEE--HHHHHHHHHHHHHHHHH-------HHHHHHHHH--EEEEEEE---EEEEEEE---EEEE--HHHHHHHHHHHHEEEEEEEE------EEEEEEE-------EEEEEEEEEEE----------HHHHHHHHHHH--EEEE---EEEEE-----------HHHHHHHHHHHHH----------HHHHHHHHH-------EEEE----------------HHHHHHHHHHHHHHHHH----------------EEEEEEE----------HHHHHHHHHHHHHHHHH---------------------- PAPD1_1 ssp --------HHE-----H------HHHHHE---------------------------------HHHHHHHHHHHHH-EEEEEE-----HHHHHHHHHH------EEEE----HEEHHEEHHHH---------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH---EEEEEE-------------EEEEEEE---------------HH---------HHHHHHHHHHHHHHHHHH-----EEEEEE-----EEEEEEE----EEEEEEEE----HHHHHHHHHHHHH---HHHHHHHHHHHHHHH------------HHHHHHHHHHHHHH--------HH------------EE----------HH---------HHHHHHHHHHHHHEEE----EEEEEE-------------EE---------------HHHHHHHHHHHHHHHHHHHHHH------------HHH-----------------------HHHHHHH---------------HH------- PAPD1_1 sspred --------------------------------------------------------------HHHHHHHHHH----EEEEE------HHHHHHHHHH---------------EEEEE-----HHHHH----------------------------------------------HHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHH----EEEEEEE-----------EEEEEE-----------------HHHHH------HHHHHHHHHHHHHHHHH-------EEEE--------EEEE----EEEEEEE----HHHHHHHHHHHHHH--HHHHHHHHHHHHHHH-------------HHHHHHHHHHHHHH----------H-----------E--------------------HHHHHHHHHHHHHHHHH------EEE--------------EEEE--------------HHHHHHHHHHHHHHHHHHHHH---------------------------HHHHH------HHHHHHHHHH---------------------- PAPD1_1 netsurfp -------------------------HH-H-------HHHH----------------------HHHHHHHHHHHH---EEEEE-----HHHHHHHHHH------EEEE----EEEEEEE-----HHHHHHHH-----------EEE----------------------------HHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH----EEEEEEEEE---------EEEEEE--------------HHH-HH---------HHHHHHHHHHHHHHHH-----EEEEEEE-----EEEEE-----EEEEEEE----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------------HHHHHHHHEHHHHH--------HHHHH---------EE----------HH----------HHHHHHHHHHHHH-H-H---EEEE-----EE-----EEEEE--------------HHHHHHHHHHHHHHHHHHHHH--------------HHHHH------------H---------HHHHHHHHH-------------------- PAPD1_1 soprano --------------------------------------------------------------HHHHHHHHHHHH--EEEEE------HHHHHHHHHH-------EE------EEEEE------HHHHH---------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHH----EEEEE-------------EEEEEE---------------HHHHH--------HHHHHHHHHHHHHHHHH-----EEEEEE------EEEEEE----EEEEEEE---HHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHH-------------HHHHHHHHHHHHHH--------HHHH---------EEE---------------------HHHHHHHHHHHHHH-------EEE--------------EEEE--------------HHHHHHHHHHHHHHHHHHHH---------------HHHH--------------------HHHHHHHHHH---------------------- PAPD1_1 consensus MKEMSANTVLDSQRQQKHYGITSPISLASPKEIDHIYTQKLIDAMKPFGVFEDEEELNHRLVVLGKLNNLVKEWISDVSESKNLPPSVVATVGGKIFTFGSYRLGVHTKGADIDALCVAPRHVERSDFFQSFFEKLKHQDGIRNLRAVEDAFVPVIKFEFDGIEIDLVFARLAIQTISDNLDLRDDSRLRSLDIRCIRSLNGCRVTDEILHLVPNKETFRLTLRAVKLWAKRRGIYSNMLGFLGGVSWAMLVARTCQLYPNAAASTLVHKFFLVFSKWEWPNPVLLKQPEESNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSTSTRTVMVEEFKQGLAVTDEILQGKSDWSKLLEPPNFFQKYRHYIVLTASASTEENHLEWVGLVESKIRVLVGNLERNEFITLAHVNPQSFPGNKEHHKDNNYVSMWFLGIIFRRVENAESVNIDLTYDIQSFTDTVYRQANNINMLKEGMKIEATHVKKKQLHHYLPAEILQKKKKQSLSDVNRSSGGLQSKRLSLDSSCLDSSRDTDNGTPFNSPASKSDSPSVGETERNSAEPAAVIVEKPLSVPPAQGLSIPVIGAKVDSTVKTVSPPTVCTIPTVVGRNVIPRITTPHNPAQGQPHLNGMSNITKTVTPKRSHSPSIDGTPKRLKDVEKFIRLESTFKDPRTAEERKRKSVDAIGGESMPIPTIDTSRKKRLPSKELPDSSSPVPANNIRVIKNSIRLTLNR PAPOLG_1 sequence -------------------------------HHHHHHHHHHHHHH--------HHHHHHHHHHHHHHHHHHHHHHHHHHHH-------------EEEEE---------------EEEE------HHHHHHHHHHHH-------EEEE-------EEEEEE--EEEEEEE-----------------HH-----HHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHH------------HHHHHHHHHHHHHH-----HHHHHHHHHHHHH-------EEE--------------------------EEE--------------HHHHHHHHHHHHHHHHHHHHHH-----HHHH-----HHHH---EEEEEEE---HHHHHHHHHHHHHHHHHHHHHHH------EEE-----------------EEEEEEEEEEEE-----------HHHHHHHHHHHHHHHHHH-------EEEEEEEEEE-------HHHHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEEEE-- PAPOLG_1 psipred ----------------------------------HHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHH---EEEEEE-EEEEE--------EEEE-------HHHHHHHHHHHHH----------------EEEEEE--EEEEHHHHHHH------------HHHHH---HHHHHH----HHHHHHHHH----HHHHHHHHHHHHHHHH---EE-----HHHHHHHHHHHHHHHH----HHHHHHHHHHHHH--------EEEE--------EEEE--------------EE--------------HHHHHHHHHHHHHHHHHHHHHHH----HHHHH---HHHHHHHHEEEEEEE----HHHHHHEEEHHHHHHHHHHHHH----EEEE------------------EEEEEEEEEEEEE-------EEEE---HHHHHHHHHHHHHHHHH-----EEEEEEEE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEEEE-- PAPOLG_1 prof -----------------EEEE----------HHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHH-----EEE---EEEEE------EEEEEE---------HHHHHHHHH----------------EEEEEEE------HHHH---------------HHHHH-------EEE----HHHHHHHH---------HHHHHHHHHHH------EEE-----HHHHHHHHHHHHH-------HHHHHHHHHH--------EE------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHHH-------------------EEEEEEE-----HHHHHHHHHHHHHHHHHHH-------EEEEEE----------------EEEEEEEEEE-----------EE---HHHHHHHHHHH------------EEEEEE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH----- PAPOLG_1 jnet --------------------------------HHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHH----EEEEE--EEE--------EEEEEEE-----HHHHHHHHHHHHH------EEEE-----EEEEEEEE---EEEEEEEEE-------------HHHHHH--HHHHHH----HHHHHHHHHH---HHHHHHHHHHHHHHHH------------HHHHHHHHHHHHHH------HHHHHHHHHHHHH------EEE------------------------EEEEE---------HHH--HHHHHHHHHHHHHHHHHHHHHH-----HHHHH-----HHH--EEEEEEEE---HHHHHHHHHHHHHHHHHHHHHHH-----EEEE-----------------EEEEEEEEEEE----------E----HHHHHHHHHHHHHHH-------EEEEEEEEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EE--- PAPOLG_1 sable ---------------------------------HHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHH----EEEEE-HHHH--EEE--EEEEEEEEE----HHHHH-HHHHHHHH------EEEE-----EEEEEE---EEEEEEEEEEE--EEE-------HHHH------HHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHH-EEE----EEEHHHHHHHHHHHHHH-----HHHHHHHHHHHHH------EEE------------EEE----HHHHH--EEEEE---EEEEE-----HHHHHHHHHHHHHHHHHHHHHHH----HHHH----------EEEEEEEEEE--HHHHHHHHHHHHHHHHHHHHHHHH---EEEEEEE--EEEE---------EEEEEEEEEEE--------EEE--HHHHHHHHHHHHHHHHH-----E-EEEEEEEE--HHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEEEE-- PAPOLG_1 proteus ---------------HH--------------HHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHH---EEEEE---------------EEEE------HHHHHHHHHHHHHH---HH-----------EEEEEE---EEEEEEEEE--------------HHHH---HHHHHH----HHHHHHHHH---HHHHHHHHHHHHHHHHH------------HHHHHHHHHHHHH-----HHHHHHHHHHHHHH-------EE-----------------------------E--------------HHHHHHHHHHHHHHHHHHHHHHH----HHHH----HHHHHH-EEEEEEEE---HHHHHHHHHHHHHHHHHHHHHHH----EEEE-------------------EEEEEEEEEEEE-------EEE----HHHHHHHHHHHHHHHHH-----EEEEEEEEH----------H-------------------------------------------------------------------EEEE------------EEE----------------------E----------------------------------------------------HHH-------------HHH--------------------------------------------EEE-EEEEEE-- PAPOLG_1 sspro4 -----------------EE------------HHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHH----EEEEE-------------EEEEEEE-----HHHHHHHHHHHHHH----EEEEEE----EEEEEEEEE-EEEEEEEEE--------------HHHH----HHHHHHH--HHHHHHHHHH---HHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHHH-----HHHHHHHHHHHHHH------EEE-------------------------EEEE--------HHH---HHHHHHHHHHHHHHHHHHHHHHH----HHHHHH--HHHHHH-EEEEEEEEE--HHHHHHHHHHHHHHHHHHHHHHHH----EEEE------------------EEEEEEEEEE---------EE--HHHHHHHHHHHHHHHH--------EEEEEEE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEE--- PAPOLG_1 psspred --EE-------------EE-E----------HHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHH---H-H-----EEEEEE--E------------EEEEE-----HHHHHHHHHHHHHH-----EEEE---EEEEEEEEEE--EEEEEEEEE---------------HH-H---HHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHH-HHHHHH----HHHHHHHHHHHHHH-----HHHHHHHHHHHHHH------EEE-------------------------EEEE----------H---HHHHHHHHHHHHHHHHHHHHHHH----HHHHH----HHHH--EEEEEEEEE--HHHHHHHHHHHHHHHHHHHHHHHH---EEEEE----------------EEEEEEEEEEEE--------EEE--HHHHHHHHHHHHHHHH--------EEEEEEEEEE-H------HHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEEE--- PAPOLG_1 spineX ---------------------------------HHHHHHHHHHHH--------HHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHH----EEEE---------------EEEEE------HHHHHHHHHHHHH-----EEEEE----EEEEEEEEE---EEEEEEEE----------------------HHHHHHH--HHHHHHHHH----HHHHHHHHHHHHHHHHH----HHH------HHHHHHHHHHHHH-------EEEEEEEEEE--------EEE--------------------------EEE--------------HHHHHHHHHHHHHHHHH--HH-----EEEEEE----HHHH---EEEEEEE---HHHHHHEE-EEEEEEEEEEEEEEEEEEEEEEEE----------------EEEEEEEEEEEEEE-----EE-----EEEEEEEEEE---EEEEEEEEEEEEEEEEEEEEEEEEE--EEEEE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ PAPOLG_1 raptorxss -------EE--------EE------------HHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHH-----EEEEE---E---------EEEEEEE-----HHHHHHHHHHHHH-------EEEE---EE-EEEEEE--EEEEEEEEE--------------HHHH----HHHHHH---HH-HHHHHHH----HHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHH-----HHHHHHHHHHHHHH--------E---------------------------EE------H--HHH--HHHHHHHHHHHHHHHHHHHHHH-----HHHHHH---HHHH--EEEEEEEEE--HHHHHHHHHHHHHHHHHHHHHHHH-----EEEE----------------EEEEEEEEEEEE--------EEE----HHHHHHHHHHHHHHHHHHH----EEEHHHHHHHHHHHH--HH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEEE--- PAPOLG_1 SPARROW -------------------------------HHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HH------EEEEE--EE---------EEEEEE------HHHHHHHHHHHHH------EEEE-----E-EEEEEE--EEEEEEEEE--------H------HHH----HHHHHH---HHHHHHHHHH---HHHHHHHHHHHHHHHHH------------HHHHHHHHHHHHHH-----HHHHHHHHHHHHHH-------EE--------------------------EEE--------------HHHHHHHHHHHHHHHHHHHHHH-----HHHH-----HHHH---EEEEEEE---HHHHHHHH-HHHHHHHHHHHHHH------EE------------------EEEEEEEEEE----------------HHHHHHHHHHHHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PAPOLG_1 *SPARROW ---------------HHH-------------HHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHH--EEEEE-EEEEEE--------EEEEE-EEEEHHHHHHHHHHHHHH--HHHHHHH---H----EEEEE----EEEEEHHHEE-----------HHHHHH--HHHHHHE------HHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHH-----HHHHHHHHHHHHHH------EEEE--H------EEE-------H----------------------HHHHHHHHHHHHHHHHHHHHHHHHHH-HHHHHHH--HHHHHHHEEEEEEE---HHHHHHHHHHHHHHHHHHHHHHHH--EEEEE-------------------EEEEEEE--E---------EEEEEE-HHHHHHHHHHHHHHHHH-----EEEEEEEE-------E---------------------------------------------------------------------------------------------------------------------------------------------------------------H--H-HHHHH----------------H-H-----------------H----------------------EEHHHEEEEHHH PAPOLG_1 HMMSTR -------------------------------HHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHH-E-EEEEEHHHHH--------EEEEEEE-----HHHH--HHHHHHH----EEEEEEE------EEEEEE--EEEEEEEEE-----E--------HHHH----HHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHH---E--HH--E-HHHHHHHHHHHHHH-----HHHHHHHHHHHHHH------EE-------------------HHHHH----EE-------E------HHHHHHHHHHHHHHHHHHHHHH-----HHHH-----HHHH--EEEEEEEEE--HHHHHHHHHHHH--HHHHHHHHH----EEEEEE----EE----------EEEEEEEEEEE-------------HHHHHHHHHHHHHHHHH--------EEEEEEEEHHHHHHH----------------------------EE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EE----EEE--- PAPOLG_1 porter --E-HHHH---------EE------------HHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHE----EEEEEE--------------EEEE------HHHHHHHHHHHHHH------EEEE------EEEEEE---EEEEEEEE---H----------HHHHHH--HHHHHH----HHHHHHHHH---HHHHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHH-----HHHHHHHHHHHHH-------EEE---------------------------E-------------E-HHHHHHHHHHHHHHHHHHHHHH-----HHHH----HHHHHHHHEEEEEEE---HHHHHHHHHHHHHHHHHHHHHH-----EEEEE---------EE-------EEEEEEEEEE---------EEEEEEEHHHHHHHHHHHHHH---HHH--EEEEEHHHHHH---------------------------------------------------------------------------------------------------------------------E-------------------------------------------------------------------------------------------------------------------EE--EEEEEE-- PAPOLG_1 spine ------------------------EE------HHHHHHHHHHHHH---------------EEEHHHHHHHHHHHHHH----------EEEE----EEE----EEEE--------EEEE-------HHHHHHHHHHHH-----HHHHHHHHH---EEEE-------HHHHHHHHHHHHH---------------------------------------HHHHHHHHHHHHHHH---------------HHHHHHHHH---------HHHHHEEEEE--------------------------------------------------EE------EEEHHHHHH-HHHHHHHH--------------------EEEEEE--------HHHHHHHH----EEEE-------EEEEE-------------------EEEEEHHHHHHH--------EEEEE------HHHHHHH--HHHHH---EE---------------HHHHHHH--------------------------------------------------------------EEEE--------------------------------EEE--------------------------------------------------HHHHHHHHHHHHH--------HHHHHHH----------------------------------------EE-----EEEE-- PAPOLG_1 nnssp -----HHHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHH-----EEEEEE--EEEE-HHHHH--------EEEEEEE-----HHHHHHHHHHHHHH------EEEE------EEEEEE--EEEEEEEEE--------------HHH-----HHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHH------------HHHHHHHHHHHHHH-----HHHHHHHHHHHHHH------EEEE--------------------------EE---------EEEEEEEEEEEEHHHHHHHHHHHHHHHH----HHHH-----HHHH--EEEEEEE----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------------------EEEEEEEEEEEEE-----EEEEEEEEEHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--HHHHHHHHH------------------------------------------------------------EEEEE-------------EEEEEEE---------------------------------------------------------------------HHHHHHHHHHH--HHHHHHHHHHHHHHH-------------------------------HHHEEEEE--EEEEEE- PAPOLG_1 pssfinder HHHH-------HHH-----EEEE------HHHHHHHHHHHHHHHH--------HHHH--EEEEE--HHHHHHHHHHHH---------EEEEE--EEEEEE--EEEE--------EEEE---------HHHHHHHHHHH------HHHHHHHH---EEE----EEEEEEHHHHHHHHH-----------HHHH--EE-------------EEEE----EE--HHHHHHHHHH----------EE----HHHHHHHHH---------HHHHHHHHHH----------------------EE-----------EEEEE----------EEE-----EEEHHHHH--HHHHHHHH--------------------EEEEEEE-------EEEEEEE-----EEEEE------EEEEEEE----------------EEEEEEEEEEEE--------EEEEEE--------HHHHH-----HHHHHHEEEEEE----------HHHHHHHHH---------------------EE-------------------------------------EEEEE-----------EEEEE------EEEE-----EEEEE-EE-------EE------------------------------------HHHHHHHHHHHH--------HHHHHHH-----------------------------------------EE----EEEEE-- PAPOLG_1 sspal -------EEEEHHHHHH------------HHHHHHHHHHHHHHHHH-EEEHHHHHHHHHHEEEHHHHHHHHHHHH-----------EEEEEEE--EEEE--EEEEEEE----------HHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHH--EEEEEEE---HHHHHHHHH-------------------------------HHHHHHHHH----EEEEEEEHHHHHHHHH------------HHHHHHHHHEEEEE--HHHHHEEEEEEEEE--------HHHHH-----------------------------------EEEEEEE-EEEEHHHHHHHHHEEEHHHHH----HHHHHH---HHHHHEEEEEEE--------------EEEEEEEEEE-------EEEE--------------------EEEEEEEEEE--------EEEEEEEEEE---------HHHHHHHHH---------HHHHHHHHH-HHHHHHHHH-------------------------------------------------------------EEEE--EEEE----EEEEEEE----EEEEEEE---EEEEEEEEE------------------------EEEEEEE-------------HHHHHHHHHH---------HHHHHHHHH--------------HHHHHHHHH----------------EEEEE--------- PAPOLG_1 ssp ---------------------------------HHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHH--EEEEEEE--------------EEEEE-----HHHHHHHHHHHHH------EE---------EEEEEE--EEEEEEEEE---------------HHHHHHHHHHHHH----HHHHHHHHH-----HHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHH-----HHHHHHHHHHHHE-------EEEE--------------------------EE---------------HHHHHHHHHHHHHHHHHHHHH-----HHHHH--HHHHHH-HEEEEEEE----HHHHHH----HHHHHHHHHHHHH-----EEEE------------------EEEEEEEEEEEE-----------EE-HHHHHHHHHHHHHHH------HEEEEEEEHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEEE--- PAPOLG_1 sspred -------------------------------HHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHH------------EEEEEE-------------EEEEEEE-----HHHHHHHHHHHHH-------EEE-----E-EEEEEE--EEEEEEEEE---------------HH-----HHHHHH---HHHHHHHHHH------HHHHHHHHHHHHHH-------------HHHHHHHHHHHHH-----HHHHHHHHHHHHH-------EEE--------------------------EEE---------HHHH-HHHHHHHHHHHHHHHHHHHHHH-----HHHH------HHH--HEEEEEEEE--HHHHHHHHHHHHHHHHHHHHHHHH-----EE-------------------EEEEEEEEE----------EEE--HHHHHHHHHHHH------------EEEE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ PAPOLG_1 netsurfp -------------------------------HHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHH-----EEEEEE-----E------EEEEEE------HHHHHHHHHHHHHH----EE-EE-----EEEEEEEE---EEEEEEEE--------------HHHH-----HHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHH-----------HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHH-----EEEE------------------------EEEE--------HHHHH--HHHHHHHHHHHHHHHHHHHHHH----HHHHH----HH--H--EEEEEEE---HHHHHHHH-HHHHHHHHHHHHHHH----EEEE------------------EEEEEEEEE-----------E-----HHHHHHHHHHHHH--------EEEEEEEEE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEE--- PAPOLG_1 soprano -------------------------------HHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHH----EEEEE--------------EEEEE------HHHHHHHHHHHHH-------EEE-------EEEEEE--EEEEEEEEE--------------HHHH----HHHHHH---HHHHHHHHHH---HHHHHHHHHHHHHHHHH------------HHHHHHHHHHHHHH-----HHHHHHHHHHHHH-------EEE---------------------------EE--------------HHHHHHHHHHHHHHHHHHHHHH-----HHHH-----HHHH--EEEEEEEE---HHHHHHHHHHHHHHHHHHHHHHH----EEEEE-----------------EEEEEEEEEEE---------EEE---HHHHHHHHHHHHHHH--------EEEEEEEE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEEE--- PAPOLG_1 consensus MASGSGDSVTRRSVASQFFTQEEGPGIDGMTTSERVVDLLNQAALITNDSKITVLKQVQELIINKDPTLLDNFLDEIIAFQADKSIEVRKFVIGFIEEACKRDIELLLKLIANLNMLLRDENVNVVKKAILTMTQLYKVALQWMVKSRVISELQEACWDMVSAMAGDIILLLDSDNDGIRTHAIKFVEGLIVTLSPRMADSEIPRRQEHDISLDRIPRDHPYIQYNVLWEEGKAALEQLLKFMVHPAISSINLTTALGSLANIARQRPMFMSEVIQAYETLHANLPPTLAKSQVSSVRKNLKLHLLSVLKHPASLEFQAQITTLLVDLGTPQAEIARNMPSSKDTRKRPRDDSDSTLKKMKLEPNLGEDDEDKDLEPGPSGTSKASAQISGQSDTDITAEFLQPLLTPDNVANLVLISMVYLPEAMPASFQAIYTPVESAGTEAQIKHLARLMATQMTAAGLGPGVEQTKQCKEEPKEEKVVKTESVLIKRRLSAQGQAISVVGSLSSMSPLEEEAPQAKRRPEPIIPVTQPRLAGAGGRKKIFRLSDVLKPLTDAQVEAMKLGAVKRILRAEKAVACSGAAQVRIKILASLVTQFNSGLKAEVLSFILEDVRARLDLAFAWLYQEYNAYLAAGASPRLCWRRHSSQRVPWRWSASTARMRVAPIWACPHFET Symplekin_2 sequence -------------------------------HHHHHHHHHHHHH----HHHHHHHHHHHHHHH------HHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHH--------------------------------HHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHH----HHHHHHHHHHHH--------HHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHH----HHHHHH-------------------HH-------------------------------------HHHHH-------HHHHHHHHHHHHH-------HHHHHH--------HHHHHHHHHHHHHHH---------------------HHHHHHHHHHHHHHHHH------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------------------------HHHH------------- Symplekin_2 psipred --------------HHH--------------HHHHHHHHHHHHHH---HHHHHHHHHHHHHHH-----HHHHHHHHHHHHH----HHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHEE------------------------------HHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHH--HHHHHHHHHHHH-----------HHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHH--HHHHHHHH---HHHH---------HHHH--------------------------------------HHHHHHH---HHHHHHHHHHHHHH-----HHHHHHH----------HHHHHHHH----------------------------------HHH-------------------------------------------HHHHHH-----EE----------HHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------------------HHHHHHHHHH----------- Symplekin_2 prof -----------------------------HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHH-----HHHHHHHHHHH-----HHHHHHHHHHHHHHHH--HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHH---------------------------------HHHHHHHHHHHHHHHHHH--------HHHHHHHHHHHHHHH--HHHHHHHHHHHHH---------HHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHH---HHHHHHH----------------------------------------------------------HHHHHH-----HHHHHHHHHHHHH------HHHHHHHH---------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHH-------------EEEEEEEEE-----HHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHH------------------HHHHHHHHHHHHHHHHHH------ Symplekin_2 jnet --------------HHHH--------------HHHHHHHHHHHH----HHHHHHHHHHHHHHH----HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHEEEE------------------------------HHHHHHHHHHHHHHHHHHH---------EEEHHHHHHHHHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHH---HHHHHHH-----HH-----------HHH-------------------------------------HHHHHHH----HHHHHHHHHHHHHH--HHHHHHHHHH-----------HHHHHHHHHH-------------------------------HHHHH--------------------------------------------------HHHH-HHHH-----HHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------------------HHHHH-------------- Symplekin_2 sable --------HHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHH----HHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHH------------------------------HHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------HHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHH-HHHHHHHHHHHHHH-------------------------------------------------HHHHHHHHHHHH--HHHHHHHHHHHHHH--HHHHHHHHHHHHHH------HHHHHHH-------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----------------HHHHHHHHHHHHH---------- Symplekin_2 proteus ------HHHHHHHHHHHHHHHH-------HHHHHHHHHH--HH------HHHHHHHHHHHHH------HHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHH--HHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHH-------HHEHEEHHHHEEEEE-------------------H-----------HHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHH-HHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHH----HHHHHHH----------------HHHHHHHH---------------------HHHHHH---------HH--H----HHHHHHHHHHH-----HH--HHHHHH---HH----HHHHHHHHHHHHHHHHH------HHHHHH-------HEE----EEEEH--------EEEE-------------------------------H------EHEEEHHH------HHHHHHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------EEEEE--------EE------EE---E-------- Symplekin_2 sspro4 -------------HHHHHH-----------HHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHH------------------HHH---------HHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHH-HHHHHHHHHHHHHH---------HHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHH------HHHHHH-------------------------HHHH-----HHHHHHHHHHH--HHHHHHHHHHHHHH---HHHHHHHHH-----------HHHHHHHHH--------------------------------HHHHHHH---------------------------------------HHHHH---HHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------------------HHHHHHHHHHH---------- Symplekin_2 psspred --------------HHH--------------HHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHH-------------------HHH---------HHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------HHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHH---HHHHHHH-----------------HHHHHHH----------------------HHH---------HHHHH------HHHHHHHHHHHHHH-HHHHHHHHHHH---HH----HHHHHHHHHHHHHHHHHH---------HH----HHHHHHHHHHHHHHHHHHHH------------------HHHHHH------------HHH--------------------HHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----------------EEE--------EEEEE------ Symplekin_2 spineX ---------------HEEE------------HHHHHHHHHHH-----HHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHEE------HHHHHHHHHHHHHHHHHHHHH------EEEEEEEEEEEEEEE---------------------E---------HHHHHHHHHHHEEEEE----------EEEEEEEEEEEEEEEE-HHHHHHHHHHHHHH--------HHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHH------------------------------------------------------------EE---------H--------HHHHHHHHHHHH---------HHH------------------H------------------------------------------------------------------------------------------EEE-----------HHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----------------HHHHHHHHHHHHHH----------- Symplekin_2 raptorxss -------HHH---HHHHHHH-----------HHHHHHHHHHHHH----HHHHHHHHHHHHHHHH--HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHH-------------------HHH---------HHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHH-HHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHHHH--------HHHHHHHHHHHHH-HHHHHHH---HHHHHHH-------HHHHHH------------------------HHH----------HHHHHHH--HHHHHHHHHHHHH---HHHHHHHHHH------------HHHHHH--------------------------------HHHHHHHHH-------------------HHHH-------------------------HHHH--H-------HHHHHHHHHHHHHHHHH-HHHHH----HHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----------HH-----HHHHHHHHHHHEE----------- Symplekin_2 SPARROW --------H----HHHHHHHHH---------HHHHHHHHHHHH-----HHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHEEEE------------------HHH---------HHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHH--HHHHHHHHHHHHH----------HHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHH-HHHHHHHH--HHHHH---------HHHHHH----------------------------------------------HHHHHHHHHHHHH------HHHHH---------------HHHH-----------------------------------HHHHH-------------------------------------------------HHHH-----------HHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHH---HHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHH-------------------HHHHHHHHHH----------- Symplekin_2 *SPARROW --------EEHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHEEEEE------------------EE-------EE-HHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------HHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHH-------------------HHHHHHHHHHHHHHHHHHHHHE----HHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------------------------HHHHHHHHHHH------------HHH-H----------------------HHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHH-HH-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------------HHHHHHHHHHHHHHHHHH-HHHH- Symplekin_2 HMMSTR -----------HHHHHHHH------------HHHHHHHHHHHH-----HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHH-------------------HHH---------HHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHH------HH---HHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHH-----HHHHH-----HHH--------HHHHHHHHH--------------------------------HHHHHHHHH-----HHHHHHHHHHH---------HHHH----HHH--HHHHHHHHHHHHHHHHHHH------HHH---------EEE-----EEEE---------EEE---------------------------------------EEE-HHH------HHHHHHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------------------------------------- Symplekin_2 porter ---------HHHHHHHHHHHHH----------HHHHHHHHHHHHH-------HHHHHHHHHHH----HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---EEEEE------HHHHHHHHH--EEEEE----------------------------EEEEHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHH----HHHHHHH----------------HHHHHHH----------------------HHHHHH-------HHHHHHHHH-----HHHHHHHHHH-------HHHHHHH--------HHHHHHHHHHHHHHHHHH------HHHHHHHH--HHHHHHHHHHHHHHHHHHH----EEEE-------HHHHHHHHHH-----EEE------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------EEEE---------------HHHHH----------- Symplekin_2 nnssp -------EEEEEEEEEEEEE-----------HHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----EEEEEE-----EEEEEEEEE--EEEEE------------------------------HHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHH----HHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHH----HHHHHHH---------------HHHHHHHH-------------------------------------HHHHHHH--HHHHHHHHHHHHHH---------------------HHHHHHHHHHHHHHHHHH-----------------HHHHHHHHHHHHHHHHHH---EEEEE-------HHHHHHHHHHH---------------------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---------------------------------------- Symplekin_2 pssfinder HH--------HHHHHHHHHHH-----------HHHHHHHHHHHH------HHHHHHHHHHHH----HHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHH---EEEEE------HHHHHHHHHHHHEEE--HHHHHHHHHHHHH--------------EEHHHHHHHHHHHHHHHHHHH---------HHHHHHHHHHHH---HHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHH----HHHHHHH---------------HHHHHHH---------HHH-----------HHHHHH-----HHHHHHHHH-------HHHHHHHHHHH-------HHHHHH--------HHHHHHHHHHHHHHHHHH-----HHHHHHHH----HHHHHHHHHHHHHHHH-----EEEEEE------HHHHHHHHH------EEEE----------HHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHH--------EE------EEEE---------- Symplekin_2 sspal -------EEEE--EEEEEEE---------HHHHHHHHHHHHHH----------HHHHHHHHH---HHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHH--EEEEEEE----HHHHHHHHHHHHEEEE----------HHHHHHHHHHH---------HHHHHHHHHHHHHHHHHEEEE-------HHHHHHHHHHHHHH--HHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHH----HHHHHHEEEEEEE---HHHHHHHHH---------------HHHHHHHHH----HHHHHHHHH----------------------HHHHH----------EEEEEEEE--HHHHHHHHHH------HHHHHHHHHHHHHHH--------------------------EEEE--EEEE-------EEEEEEE-------HHHHH---------EEEEE---------HHHHHHHHHHHH---HHHHHHHHH-HHHHHHHHH---HHHHHHHEEEEEEE-----------HHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHH-------------------------------------- Symplekin_2 ssp ----------HH-HHHHHHHHHH--------HHHHHHHHHHHHHH----HHHHHHHHHHHHHHH------HHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE-----HHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHEEEE-----------------------------HHHHHHHHHHHHHHHHHHH---------HHHHHHHHHHHHHH-HHHHHHHHHHHHH-------HHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHH--HHHHHHH----------------HHHHHHH------------------------------HHHHHHHHHHH--------HHHHHHHHHH-HHHHHHHHHH-EE-E-----HHHHHHHHHHHHHHHH-----------HH-------HHH------------------HHHHH---------------------------HHHHHHHHHHHHEEE---------HHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------HH--------EEHHHHHHHHH------------ Symplekin_2 sspred ---------------------HH---------HHHHHHHHHHHH----HHHHHHHHHHHHHHHH--HHHHHHHHH-HHHHH----HHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHH-----H-HHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHEEEEHHH------------------H---------E-HHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHH-HHHHHHHHHHHHHHH---------HHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHH---HHHHHHHHHHHHH------------HHHHH-----------------------------------HHHHHH-----HHHHHHHHHHHHHH--HHHHHHHHHHH--HH-------HHHHHHHHHH-------------------------------HHHHHH--------------------------------------------HH--H-HHH---------HHHHHHHHHHHHHHHHHHHHHHH-------EEEEEEEEEE----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----------------EEE-----------EE------- Symplekin_2 soprano -------------HHHHHH------------HHHHHHHHHHHHH----HHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHEEEE------------------------------HHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHH-HHHHHHHHHHHHHH---------HHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHH---HHHHHHH-----------------HHHHHH-----------------------------------HHHHHHH----HHHHHHHHHHHHH----H-HHHHHHH---------HHHHHHHHHHHHH------------------------------HHHHH--------------------------------------------------HHHH--H-------HHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------------------H-HHHHHHH------------ Symplekin_2 consensus